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https://www.readbyqxmd.com/read/29458218/effects-of-curcuminoids-plus-piperine-on-glycemic-hepatic-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#1
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
INTRODUCTION: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients. METHODS: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months...
February 19, 2018: Drug Research
https://www.readbyqxmd.com/read/29457707/peripheral-neurostimulation-breaks-the-shuffling-steps-patterns-in-parkinsonian-gait-a-double-blind-randomized-longitudinal-study-with-automated-mechanical-peripheral-stimulation
#2
Manuela Galli, Caterina Vicidomini, Ana F Rozin Kleiner, Laura Vacca, Veronica Cimolin, Claudia Condoluci, Fabrizio Stocchi, Maria F DE Pandis
BACKGROUND: The shuffling steps pattern is a typical feature of gait in patients affected by Parkinson's Disease (PD), which progressively reduces their quality of life, being related to the risk of falls in this population. Recently, Automated Mechanical Peripheral Stimulation (AMPS) was presented as an integrative rehabilitative treatment based on peripheral stimulation able to improve the gait spatiotemporal parameters in PD patients. AIM: To evaluate the effects of AMPS on shuffling steps pattern by analyzing the kinematic and spatio-temporal gait parameters...
February 19, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29457671/abstinence-and-reduced-frequency-of-use-are-associated-with-improvements-in-quality-of-life-among-treatment-seekers-with-cannabis-use-disorder
#3
Christina A Brezing, C Jean Choi, Martina Pavlicova, Daniel Brooks, Amy L Mahony, John J Mariani, Frances R Levin
BACKGROUND AND OBJECTIVE: Many patients with cannabis use disorder (CUD) do not achieve or do not have abstinence as a goal of treatment, rather they reduce their use. Assessing outcome measures as they relate to functioning and reductions in cannabis use is an important area of study. Quality of life (QoL) shows promise as one such measure. Past studies have demonstrated gender differences in QoL and CUD. We aim to assess (1) the relationship between cannabis use and QoL and (2) gender effects in an outpatient medication treatment study for CUD...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457627/combination-pharmacotherapy-for-the-treatment-of-fibromyalgia-in-adults
#4
REVIEW
Joelle Thorpe, Bonnie Shum, R Andrew Moore, Philip J Wiffen, Ian Gilron
BACKGROUND: Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side effects. OBJECTIVES: To assess the efficacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, and Embase to September 2017...
February 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29457540/therapeutic-efficacy-of-cd34-cell-involved-mononuclear-cell-therapy-for-no-option-critical-limb-ischemia-a-meta-analysis-of-randomized-controlled-clinical-trials
#5
Tianyue Pan, Zheng Wei, Yuan Fang, Zhihui Dong, Weiguo Fu
Early-phase clinical trials in patients with critical limb ischemia (CLI) have shown positive results of mononuclear cell therapy. The current meta-analysis investigated whether cluster of differentiation (CD) 34+ mononuclear cell therapy (CD34+ MCT) is effective for no-option CLI. Ten randomized controlled clinical studies of CD34+ MCT for no-option CLI with 479 patients were identified and analyzed for pooled results. Compared to control groups, the CD34+ MCT was associated with lower total amputation (odds ratio (OR): 0...
February 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29457221/association-of-stat6-gene-variants-with-food-allergy-diagnosed-by-double-blind-placebo-controlled-food-challenges
#6
C D van Ginkel, M E Pettersson, A E J Dubois, G H Koppelman
This study describes the role of two STAT6 gene variants in food allergy using data of patients and their parents who underwent double-blind placebo-controlled food challenges (DBPCFCs). After quality control, 369 trios were analyzed including 262 children (71.0%) with food allergy. Associations were tested by family based association testing (FBAT). The A alleles of both SNPs were associated with food allergy (p=0.036 and p=0.013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher sIgE levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk DBPCFCs (all p<0...
February 19, 2018: Allergy
https://www.readbyqxmd.com/read/29456638/biobran-mgn-3-an-arabinoxylan-rice-bran-enhances-nk-cell-activity-in-geriatric-subjects-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Ahmed F Elsaid, Magda Shaheen, Mamdooh Ghoneum
Aging is associated with a decline in natural killer (NK) and natural killer T (NKT) cell function that may contribute to increased susceptibility to malignancy and infection. A preliminary investigation was conducted examining the hypothesis that arabinoxylan rice bran (Biobran/MGN-3), a denatured hemicellulose with known immunomodulatory activity, could counteract this decline in NK/NKT cell activity in geriatrics. A total of 12 healthy geriatric subjects of both sexes and over 56 years old, participated in a randomized, double-blind, placebo-controlled clinical trial...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456507/the-effects-of-vitamin-d-supplementation-on-signaling-pathway-of-inflammation-and-oxidative-stress-in-diabetic-hemodialysis-a-randomized-double-blind-placebo-controlled-trial
#8
Hamed Haddad Kashani, Elahe Seyed Hosseini, Hossein Nikzad, Alireza Soleimani, Maryam Soleimani, Mohammad Reza Tamadon, Fariba Keneshlou, Zatollah Asemi
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU ( n = 30) or placebo ( n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29456348/efficacy-of-dexmedetomidine-as-an-adjuvant-to-local-anesthetic-agent-in-scalp-block-and-scalp-infiltration-to-control-postcraniotomy-pain-a-double-blind-randomized-trial
#9
Shankar Vallapu, Nidhi Bidyut Panda, Navneh Samagh, Neerja Bharti
Context: Scalp infiltration and scalp block are being used to manage postcraniotomy pain. Dexmedetomidine has been successfully used as an adjuvant in regional anesthesia. The study was intended to compare whether addition of dexmedetomidine prolonged the duration of analgesia as well as to compare the two techniques. Aims: The primary objective was to assess whether addition of dexmedetomidine to bupivacaine prolonged the duration of analgesia. The secondary objective was to compare between scalp nerve block and scalp infiltration as techniques for pain relief...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456079/phase-iv-randomized-clinical-study-peginterferon-alfa-2a-with-adefovir-or-entecavir-pre-therapy-for-hbeag-positive-chronic-hepatitis-b
#10
Chao-Wei Hsu, Wei-Wen Su, Chuan-Mo Lee, Cheng-Yuan Peng, Wan-Long Chuang, Jia-Horng Kao, Heng-Cheng Chu, Yi-Hsiang Huang, Rong-Nan Chien, Yun-Fan Liaw
BACKGROUND: Efficacy of sequential therapy with nucleos(t)ide analogues and interferons versus monotherapy in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) remains unexplored. We aimed to assess efficacy and safety of sequential therapy with adefovir (ADV) or entecavir (ETV) followed by peginterferon (PEG-IFN) alfa-2a in Taiwanese patients with HBeAg-positive. METHODS: This randomized, placebo-controlled, double-blind trial was conducted at nine sites in Taiwan from April 2010 to October 2013...
February 15, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29456025/effectiveness-of-user-and-expert-driven-web-based-hypertension-programs-an-rct
#11
Sam Liu, Dina Brooks, Scott G Thomas, Gunther Eysenbach, Robert P Nolan
INTRODUCTION: The effectiveness of self-guided Internet-based lifestyle counseling (e-counseling) varies, depending on treatment protocol. Two dominant procedures in e-counseling are expert- and user-driven. The influence of these procedures on hypertension management remains unclear. The objective was to assess whether blood pressure improved with expert-driven or user-driven e-counseling over control intervention in patients with hypertension over a 4-month period. STUDY DESIGN: This study used a three-parallel group, double-blind randomized controlled design...
February 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29455269/the-efficacy-and-safety-of-targeted-therapy-with-or-without-chemotherapy-in-advanced-gastric-cancer-treatment-a-network-meta-analysis-of-well-designed-randomized-controlled-trials
#12
REVIEW
Ting-Ting Zhao, Hao Xu, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao
BACKGROUND: Advanced gastric cancer (AGC) is a severe malignant tumor associated with high mortality. Targeted therapy is an important approach for improving the therapeutic effects of AGC treatment. This study evaluates the efficacy and safety of targeted agents for AGC patients. METHODS: PubMed, EmBase, and the Cochrane Library were searched for double-blind randomized controlled trials (RCTs) of AGC treatments published prior to July 2017. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and severe adverse effects (AEs) were evaluated to determine the efficacy and safety of targeted agents...
February 17, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29455237/randomized-controlled-trial-of-2-lidocaine-gel-versus-water-based-lubricant-for-multi-channel-urodynamics
#13
Begüm Z Özel, Vanessa Sun, Avita Pahwa, Rebecca Nelken, Christina E Dancz
INTRODUCTION AND HYPOTHESIS: The purpose of the study was to determine if there is a difference in pain during and after multichannel urodynamic testing in women when using 2% lidocaine gel versus water-based lubricant. METHODS: This was a randomized, controlled, double-blinded study. Women scheduled to undergo urodynamic testing were invited to participate. Participants were randomized to lidocaine 2% gel or water-based lubricant for use during testing. Both participant and examiner were blinded to the type of gel...
February 17, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29454678/treatment-of-coenzyme-q10-for-24-weeks-improves-lipid-and-glycemic-profile-in-dyslipidemic-individuals
#14
Peiwen Zhang, Chen Yang, Honghui Guo, Jiaji Wang, Shengqiang Lin, Huamei Li, Yan Yang, Wenhua Ling
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks...
December 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29454501/postoperative-inflammation-and-insulin-resistance-in-relation-to-body-composition-adiposity-and-carbohydrate-treatment-a-randomised-controlled-study
#15
Nilanjana Tewari, Sherif Awad, František Duška, Julian P Williams, Andrew Bennett, Ian A Macdonald, Dileep N Lobo
BACKGROUND & AIMS: The aims of this study were to identify whether differences in distribution of adipose tissue and skeletal muscle in obese and non-obese individuals contribute to the magnitude of the postoperative inflammatory response and insulin resistance, with and without preoperative treatment with carbohydrate drinks. METHODS: Thirty-two adults (16 obese/16 non-obese) undergoing elective major open abdominal surgery participated in this 2 × 2 factorial, randomised, double-blind, placebo-controlled study...
February 14, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29454255/effects-of-adjunctive-eslicarbazepine-acetate-on-neurocognitive-functioning-in-children-with-refractory-focal-onset-seizures
#16
Sergiusz Jóźwiak, P Veggiotti, J Moreira, H Gama, F Rocha, P Soares-da-Silva
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). METHODS: Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up...
February 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29454039/effect-of-long-term-selenium-supplementation-on-mortality-results-from-a-multiple-dose-randomised-controlled-trial
#17
REVIEW
Margaret P Rayman, Kristian Hillert Winther, Roberto Pastor-Barriuso, Frederick Cold, Marianne Thvilum, Saverio Stranges, Eliseo Guallar, Søren Cold
BACKGROUND: Selenium, an essential trace element, is incorporated into selenoproteins with a wide range of health effects. Selenoproteins may reach repletion at a plasma selenium concentration of ~125µg/L, at which point the concentration of selenoprotein P reaches a plateau; whether sustained concentrations higher than this are beneficial, or indeed detrimental, is unknown. OBJECTIVE: In a population of relatively low selenium status, we aimed to determine the effect on mortality of long-term selenium supplementation at different dose levels...
February 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29453755/effect-of-nicotine-on-repeated-bouts-of-anaerobic-exercise-in-nicotine-na%C3%A3-ve-individuals
#18
Robert Johnston, Melissa Crowe, Kenji Doma
PURPOSE: Nicotine is a psychostimulant that is reported to be commonly supplemented by athletes. The purpose of the current study was to determine the effects of a rapidly absorbed form of nicotine on repeated bouts of anaerobic exercise, perception of exertion and a range of cardiovascular variables while monitoring side effect profiles. METHODS: Sixteen healthy, nicotine naïve male athletes (24.1 ± 5.3 years, 179.0 ± 8.8 cm, 81.7 ± 13.5 kg, BMI 25.5 ± 3.0, Body fat% 13...
February 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29453671/comparative-evaluation-of-pharmacokinetics-and-pharmacodynamics-of-insulin-glargine-glaritus-%C3%A2-and-lantus-%C3%A2-in-healthy-subjects-a-double-blind-randomized-clamp-study
#19
Ashima Bhatia, Shraddha Tawade, Mushtaque Mastim, Eliford Ngaimisi Kitabi, Mathangi Gopalakrishnan, Manish Shah, Sridhar Yeshamaina, Joga Gobburu, Maharaj Sahib, Dipak Thakur, K M Prasanna Kumar
AIMS: The objective of the study was to compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties of an insulin glargine formulation, Glaritus ® (test) with the innovator's formulation Lantus ® (reference) using the euglycemic clamp technique in a single-dose, double-blind, randomized, two sequences, four-period replicate crossover study in healthy volunteers (n = 40). METHODS: Subjects received subcutaneous administration of the insulin glargine (0...
February 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29453466/effects-of-intrathecal-dexmedetomidine-as-an-adjuvant-to-hyperbaric-bupivacaine-for-spinal-anaesthesia-in-adults-undergoing-elective-infra-umbilical-surgery
#20
Binod Gautam, Sujata Niroula, Mona Sharma, Sushila Moktan Lama
INTRODUCTION: Various adjuvants to local anaesthetic are used to improve quality and duration of spinal anaesthesia. Dexmedetomidine, a novel alpha-2 adrenergic agonist, has been proposed to augment local anaesthetic effects. This study aims to investigate effects of intrathecal Dexmedetomidine on duration of analgesia and duration of sensory block during spinal anaesthesia. METHODS: In this randomized double-blind study 38 patients were allocated into each of two groups...
October 2017: JNMA; Journal of the Nepal Medical Association
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