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https://www.readbyqxmd.com/read/27936214/deep-neuromuscular-block-improves-surgical-conditions-during-bariatric-surgery-and-reduces-postoperative-pain-a-randomized-double-blind-controlled-trial
#1
Bart Torensma, Chris H Martini, Martijn Boon, Erik Olofsen, Bas In 't Veld, Ronald S L Liem, Mireille T T Knook, Dingeman J Swank, Albert Dahan
BACKGROUND: It remains unknown whether the administration of a deep neuromuscular block (NMB) during bariatric surgery improves surgical conditions and patient outcome. The authors studied the effect of deep versus moderate NMB in laparoscopic bariatric surgery on surgical conditions and postoperative pain. METHODS AND RESULTS: One hundred patients scheduled to undergo elective bariatric surgery were randomized to a deep NMB (post-tetanic-count 2-3) or a moderate NMB (train-of-four 1-2)...
2016: PloS One
https://www.readbyqxmd.com/read/27936169/effects-of-supplementation-of-the-synbiotic-ecologic%C3%A2-825-fos-p6-on-intestinal-barrier-function-in-healthy-humans-a-randomized-controlled-trial
#2
E Wilms, J Gerritsen, H Smidt, I Besseling-van der Vaart, G T Rijkers, A R Garcia Fuentes, A A M Masclee, F J Troost
BACKGROUND AND AIMS: Probiotics, prebiotics and synbiotics have been suggested as dietary strategies to improve intestinal barrier function. This study aimed to assess the effect of two weeks synbiotic supplementation on intestinal permeability under basal and stressed conditions. Secondary aims were the assessment of two weeks synbiotic supplementation on systemic immune function and gastrointestinal symptoms including defecation pattern. DESIGN: Twenty healthy adults completed a double-blind, controlled, randomized, parallel design study...
2016: PloS One
https://www.readbyqxmd.com/read/27935975/baseline-body-mass-index-and-the-efficacy-of-hypoglycemic-treatment-in-type-2-diabetes-a-meta-analysis
#3
Xiaoling Cai, Wenjia Yang, Xueying Gao, Lingli Zhou, Xueyao Han, Linong Ji
AIM: The aim of this study is to compare the effects of hypoglycemic treatments in groups of patients categorized according to the mean baseline body mass indexes (BMIs). METHODS: Studies were identified by a literature search and all the studies were double blind, placebo-controlled randomized trials in type 2 diabetes patients; study length of ≥12 weeks with the efficacy evaluated by changes in HbA1c from baseline in groups. The electronic search was first conducted in January 2015 and repeated in June 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27935738/the-coronary-sinus-reducer-clinical-evidence-and-technical-aspects
#4
Francesco Giannini, Andrea Aurelio, Richard J Jabbour, Luca Ferri, Antonio Colombo, Azeem Latib
Chronic refractory angina is often a disabling condition, predominantly due to severe obstructive coronary artery disease, that is inadequately controlled by optimal medical therapy and not amenable to further percutaneous or surgical revascularization. Mortality rates associated with this condition are relatively low in clinically stable patients. However, it is associated with a high hospitalization rate and a reduction in both exercise capacity and quality of life. Due to the paucity of available treatment options, there is an unmet need for new therapies for these patients and for a reduction in the associated economic healthcare burden...
December 9, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27935737/low-level-laser-therapy-for-reducing-the-hip-waist-and-upper-abdomen-circumference-of-individuals-with-obesity
#5
Gregory C Roche, Steven Shanks, Robert F Jackson, Laura Jane Holsey
OBJECTIVE: To assess the effectiveness of low-level laser therapy (LLLT) for reducing hip, thigh, and abdomen circumference of individuals with body-mass index (BMI) between 30 and 40 kg/m(2). BACKGROUND: Previous studies demonstrated the effectiveness of LLLT for reducing body circumference in the hips, thighs, and abdomen of nonobese individuals with a BMI <30 kg/m(2). METHODS: In this randomized, double-blind sham-controlled study, obese, but otherwise healthy, individuals were randomized to undergo 30-min LLLT (n = 28) or sham treatments (n = 25) three times weekly for 4 weeks...
December 9, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27935240/effects-of-liraglutide-on-cardiovascular-risk-factors-in-patients-with-type-1-diabetes
#6
Thomas F Dejgaard, Nanna B Johansen, Christian S Frandsen, Ali Asmar, Lise Tarnow, Filip K Knop, Sten Madsbad, Henrik U Andersen
We investigated the short-term effect of adding liraglutide 1.8 mg once daily to insulin treatment on cardiovascular risk factors in patients with type 1 diabetes. In total, 100 overweight (BMI ≥25 kg/m(2) ) adult patients (age ≥18 years) with type 1 diabetes and HbA1c ≥8% (64 mmol/mol) were randomised to liraglutide 1.8 mg or placebo added to insulin treatment in a 24-week double-blinded, placebo-controlled trial. At baseline and after 24 weeks of treatment, 24-h blood pressure and heart rate, pulse pressure, pulse wave velocity, and carotid intima-media thickness were evaluated...
December 9, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27935229/cortico-limbic-connectivity-in-maoa-l-carriers-is-vulnerable-to-acute-tryptophan-depletion
#7
Patrick Eisner, Martin Klasen, Dhana Wolf, Klaus Zerres, Thomas Eggermann, Albrecht Eisert, Mikhail Zvyagintsev, Pegah Sarkheil, Krystyna A Mathiak, Florian Zepf, Klaus Mathiak
INTRODUCTION: A gene-environment interaction between expression genotypes of the monoamine oxidase A (MAOA) and adverse childhood experience increases the risk of antisocial behavior. However, the neural underpinnings of this interaction remain uninvestigated. A cortico-limbic circuit involving the prefrontal cortex (PFC) and the amygdala is central to the suppression of aggressive impulses and is modulated by serotonin (5-HT). MAOA genotypes may modulate the vulnerability of this circuit and increase the risk for emotion regulation deficits after specific life events...
December 9, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27935183/metformin-in-adults-with-type-1-diabetes-design-and-methods-of-reducing-with-metformin-vascular-adverse-lesions-removal-an-international-multicentre-trial
#8
J R Petrie, N Chaturvedi, I Ford, I Hramiak, A D Hughes, A J Jenkins, B Klein, R Klein, T C Ooi, P Rossing, N Sattar, C D A Stehouwer, H M Colhoun
INTRODUCTION: Cardiovascular (CV) disease is a major cause of reduced life expectancy in type 1 diabetes (T1D). Intensive insulin therapy prevents CV complications but is constrained by hypoglycaemia and weight gain. Adjunct metformin reduces insulin dose requirement and stabilises weight but there are no data on its cardiovascular effects. AIMS: We have initiated an international double-blind, randomized, placebo-controlled trial (REMOVAL: REducing with MetfOrmin Vascular Adverse Lesions in type 1 diabetes) to examine whether metformin reduces progression of atherosclerosis in adults with T1D...
December 9, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27935076/electrophysiologically-identified-piriformis-syndrome-is-successfully-treated-with-incobotulinum-toxin-a-and-physical-therapy
#9
Loren M Fishman, Allen N Wilkins, Bernard Rosner
INTRODUCTION: Piriformis syndrome is entrapment of the sciatic nerve by the piriformis muscle. METHODS: 56-person randomized, double-blinded, controlled study involving physical therapy and incobotulinum toxin A or placebo. INCLUSION CRITERIA: 3 standard deviation delay of posterior tibial (PT) or fibular FN) H-reflexes in flexion, adduction and internal rotation (FAIR-test), and normal paraspinal EMG. OUTCOME MEASURES: adverse side-effects, visual analogue scale (VAS), H-reflex delay in FAIR-test...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27934805/comparison-of-clinical-effects-of-beclomethasone-dipropionate-budesonide-in-treatment-of-children-with-mild-persistent-asthma-a-double-blind-randomized-controlled-study
#10
Anju Singh, Devki Nandan, Vivek Dewan, Jhuma Sankar
BACKGROUND & OBJECTIVES: Various inhaled corticosteroids (ICSs) are available to control the symptoms of asthma. Although beclomethasone dipropionate (BDP) and budesonide (BUD) are one of the oldest ICSs, their wide availability and low cost make them attractive options in developing countries. Due to lack of consensus on which of the two drugs is better for controlling mild persistent asthma, we undertook this study to compare the efficacy of these two drugs by measuring the change in percentage predicted forced expiratory volume in one second (FEV 1 ) from baseline in children with mild persistent asthma...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934794/angiotensin-receptor-blockers-endothelial-dysfunction-possible-correlation-therapeutic-implications
#11
REVIEW
Miroslav Radenkovic, Marko Stojanović, Ivana Milićević Nešić, Milica Prostran
The endothelium is one of the most important constituents of vascular homeostasis, which is achieved through continual and balanced production of different relaxing and contractile factors. When there is a pathological disturbance in release of these products, endothelial dysfunction (ED) will probably occur. ED is considered to be the initial step in the development of atherosclerosis. This pathological activation and inadequate functioning of endothelial cells was shown to be to some extent a reversible process, which all together resulted in increased interest in investigation of different beneficial treatment options...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27933616/efficacy-of-preoperative-ibuprofen-and-meloxicam-on-the-success-rate-of-inferior-alveolar-nerve-block-for-teeth-with-irreversible-pulpitis
#12
Yazdan Shantiaee, Sahar Javaheri, Amir Movahhedian, Sarah Eslami, Omid Dianat
OBJECTIVE: The purpose of this study was to determine whether premedication with ibuprofen or meloxicam increases the success rate of anaesthesia in teeth with irreversible pulpitis. MATERIALS AND METHODS: In this parallel, double-blind clinical trial, 92 patients diagnosed with irreversible pulpitis were randomly divided into four groups of 23 patients. The first group (the no-premedication group) received no premedication, the second group (the meloxicam group) received 7...
December 8, 2016: International Dental Journal
https://www.readbyqxmd.com/read/27933509/effect-of-shuanghu-qinggan-granule-and-yigan-yiqi-jieyu-granule-plus-lamivudine-on-chronic-hepatitis-b-patients-a-randomized-double-blind-placebo-controlled-trial
#13
Yong-An Ye, De-Lu Tian, Jian Jiang, Jun Li, Jian-Jie Chen, Zhi-Hong Li, Wei-Guo Ma, Yi-Ming Zhao, Rong-Bing Wang, Shi-Zhong Yang, Feng-Zhen Shao, Guang Ji, Da-Qiao Zhou, Tie-Jun Liu, Dong-Sheng Cheng, Wei Zhang, Ke-Wei Sun, Yu-Fen Wang, Le-Quan Min, Xiao-Ke Li
OBJECTIVE: To observe the clinical efficacy and safety of Shuanghu Qinggan Granule ( , SQG) plus Yigan Yiqi Jieyu Granule (, YYJG) combined with lamivudine (LAM) on chronic hepatitis B (CHB) patients. METHODS: The study was a multicenter, randomized, double-blinded and parallel controlled trial. A total of 320 patients were randomly allocated into 2 groups equally: 160 patients (treatment group) were given SQG and YYJG combined with LAM; and 160 patients (control group) were given LAM plus Chinese herb placebo, respectively...
December 8, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27933443/editorial-corr-%C3%A2-will-change-to-double-blind-peer-review-what-took-us-so-long-to-get-there
#14
EDITORIAL
Seth S Leopold
No abstract text is available yet for this article.
December 8, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27933401/improvement-of-abnormal-vaginal-flora-in-ugandan-women-by-self-testing-and-short-use-of-intravaginal-antimicrobials
#15
G Donders, G Bellen, F Donders, J Pinget, I Vandevelde, T Michiels, J Byamughisa
The vaginal composition of African women is more often lactobacillus-deficient compared to that of women from other areas around the world. Lactobacillus-deficient microflora is a known risk factor for serious health problems, such as preterm birth, cervix cancer, and entrapment of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The aim of this study was to assess the effect of local vaginal antibiotic or antiseptic treatment on abnormal vaginal flora (AVF), aerobic vaginitis (AV), and bacterial vaginosis (BV) among women in rural, semi-urban, and urban areas in Uganda, as compared to placebo...
December 8, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27933348/-acupuncture-in-posttonsillectomy-pain-a%C3%A2-prospective-double-blind-randomized-controlled-trial-german-version
#16
J Dingemann, B Plewig, I Baumann, P K Plinkert, S Sertel
BACKGROUND: Postoperative swallowing pain is one of the most unpleasant after-effects of tonsillectomy. During recent years, the demand for alternatives to drug-based pain therapy has continued to grow, although the topic has received little research attention until now. MATERIALS AND METHODS: A total of 46 patients were randomized into verum acupuncture, control acupuncture, and drug-based treatment groups. All patients received nonsteroidal antirheumatic drugs (NSAIDs)...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933199/efficacy-and-tolerability-of-repository-corticotropin-injection-in-patients-with-persistently-active-sle-results-of-a-phase-4-randomised-controlled-pilot-study
#17
Richard Furie, Margaret Mitrane, Enxu Zhao, Maya Das, Daner Li, Patrice M Becker
OBJECTIVE: To evaluate the efficacy of a prolonged-release formulation of a porcine adrenocorticotropic hormone analogue (repository corticotropin injection (RCI)) added to standard of care in patients requiring moderate-dose corticosteroids for symptomatic SLE. METHODS: This prospective, randomised, double-blind, phase 4, pilot study (NCT01753401) enrolled 38 patients with persistently active SLE involving skin and/or joints. Enrolled patients received RCI, 40 U daily or 80 U every other day, or volume-matched placebo gel, for 8 weeks, with dose tapering to twice weekly during weeks 5-8...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27933092/effects-of-purified-anthocyanin-supplementation-on-platelet-chemokines-in-hypocholesterolemic-individuals-a-randomized-controlled-trial
#18
Xiandan Zhang, Yanna Zhu, Fenglin Song, Yanling Yao, Fuli Ya, Dan Li, Wenhua Ling, Yan Yang
BACKGROUND: It is becoming increasingly evident that platelet chemokines are involved in distinct aspects of atherosclerosis. The aim of this study was to examine the effects of long-term supplementation with purified anthocyanins on platelet chemokines in hypercholesterolemic individuals and to identify correlations of decreased platelet chemokine levels with serum lipid and inflammatory marker levels. METHODS: A total of 146 hypercholesterolemic individuals were recruited and treated with 320 mg of purified anthocyanins (n = 73) or a placebo (n = 73) daily for 24 weeks in this randomized, double-blind, placebo-controlled trial...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27932937/effect-of-electrolyzed-high-ph-alkaline-water-on-blood-viscosity-in-healthy-adults
#19
Joseph Weidman, Ralph E Holsworth, Bradley Brossman, Daniel J Cho, John St Cyr, Gregory Fridman
BACKGROUND: Previous research has shown fluid replacement beverages ingested after exercise can affect hydration biomarkers. No specific hydration marker is universally accepted as an ideal rehydration parameter following strenuous exercise. Currently, changes in body mass are used as a parameter during post-exercise hydration. Additional parameters are needed to fully appreciate and better understand rehydration following strenuous exercise. This randomized, double-blind, parallel-arm trial assessed the effect of high-pH water on four biomarkers after exercise-induced dehydration...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27932894/effects-of-parecoxib-on-postoperative-pain-and-opioid-related-symptoms-following-gynecologic-surgery
#20
Bruce Parsons, Qijiang Zhu, Li Xie, Chunming Li, Raymond Cheung
OBJECTIVE: To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. METHODS: This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery...
2016: Journal of Pain Research
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