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https://www.readbyqxmd.com/read/29933096/improved-bone-safety-of-tenofovir-alafenamide-compared-to-tenofovir-disoproxil-fumarate-over-2-years-in-patients-with-chronic-hbv-infection
#1
Wai-Kay Seto, Yasuhiro Asahina, Todd T Brown, Cheng-Yuan Peng, Carol Stanciu, Dzhamal Abdurakhmanov, Fehmi Tabak, Tuan T Nguyen, Wan-Long Chuang, Tetsuro Inokuma, Fusao Ikeda, Teresa Antonia Santantonio, François Habersetzer, Alnoor Ramji, Audrey H Lau, Vithika Suri, John F Flaherty, Hongyuan Wang, Anuj Gaggar, G Mani Subramanian, Shrikant Mukewar, Maurizia R Brunetto, Scott Fung, Henry Lik-Yuen Chan
BACKGROUND & AIMS: Long-term use of tenofovir disoproxil fumarate (TDF) reduces bone mineral density (BMD). Tenofovir alafenamide (TAF), a new prodrug of tenofovir, has shown non-inferior efficacy to TDF in patients with chronic hepatitis B virus (HBV) infection, with improved bone effects at 48 weeks. We performed a randomized trial to evaluate the bone safety of TAF compared with TDF over 2 years, assessing baseline risk factors for bone loss, were evaluated after 2 years of treatment...
June 19, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29932518/effect-of-lower-versus-higher-protein-content-in-infant-formula-through-the-first-year-on-body-composition-from-1-to-6-years-follow-up-of-a-randomized-clinical-trial
#2
Martina Totzauer, Veronica Luque, Joaquin Escribano, Ricardo Closa-Monasterolo, Elvira Verduci, Alice ReDionigi, Joana Hoyos, Jean-Paul Langhendries, Dariusz Gruszfeld, Piotr Socha, Berthold Koletzko, Veit Grote
OBJECTIVE: The objective of this study was to investigate the effect of lower protein (LP) versus higher protein (HP) content in infant formula on body composition from 3 months to 6 years. METHODS: In a multicenter, double-blind European trial, healthy infants (N = 1,090) were randomly assigned to different protein content formulas (upper [HP] and lower [LP] limits of the European Union regulations in 2001) during the first year; breastfed infants (N = 588) were recruited for reference values...
July 2018: Obesity
https://www.readbyqxmd.com/read/29932311/rationale-and-design-of-a-multicentre-randomized-placebo-controlled-trial-of-mirabegron-a-beta3-adrenergic-receptor-agonist-on-left-ventricular-mass-and-diastolic-function-in-patients-with-structural-heart-disease-beta3-left-ventricular-hypertrophy-beta3-lvh
#3
Anne-Catherine Pouleur, Stefan Anker, Dulce Brito, Oana Brosteanu, Dirk Hasenclever, Barbara Casadei, Frank Edelmann, Gerasimos Filippatos, Damien Gruson, Ignatios Ikonomidis, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Bernhard L Gerber, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Jean-Luc Balligand
AIMS: Progressive left ventricular (LV) remodelling with cardiac myocyte hypertrophy, myocardial fibrosis, and endothelial dysfunction plays a key role in the onset and progression of heart failure with preserved ejection fraction. The Beta3-LVH trial will test the hypothesis that the β3 adrenergic receptor agonist mirabegron will improve LV hypertrophy and diastolic function in patients with hypertensive structural heart disease at high risk for developing heart failure with preserved ejection fraction...
June 22, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29932230/effects-of-selenium-supplementation-on-expression-of-sepp1-in-mrna-and-protein-levels-in-subjects-with-and-without-metabolic-syndrome-suffering-from-coronary-artery-disease-selenegene-study-a-double-blind-randomized-controlled-trial
#4
Mojgan Gharipour, Khadija Ouguerram, El-Hassane Nazih, Mansour Salehi, Mehrdad Behmanesh, Hamidreza Roohafza, Syed Mohsen Hosseini, Pouya Nezafati, Minoo Dianatkhah, Amin Gharipour, Shaghayegh Haghjoo, Nizal Sarrafzadegan, Masoumeh Sadeghi
Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases. In this clinical trial, 160 patients with angiographically documented stenosis of more than 75% in each vessel were enrolled. Patients received either 200-mg selenium yeast tablets or placebo tablets orally after a meal, once daily for 60 days...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29932077/parentage-identification-of-odontobutis-potamophlia-based-on-microsatellite-dna-markers
#5
Peipei Wang, Cheng Zhao, Shuqiao Chen, Shaowu Yin, Qintao Wang, Zecheng Li, Guoqin Zhou
Microsatellite lociwere used for parentage identification of Odontobutis potamophlia in five full-sib families. The combined exclusion probability of the first (E-1P) and the second parent (E-2P) revealed an obvious increase with the increase of number of microsatellite loci. The combined exclusion probability based on allele frequency suggested that at least eight microsatellite loci were needed for the identification of the 150 individuals from five families supported by the genetic distance analysis of individuals of these families...
June 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29931657/vitamin-d-supplementation-to-persistent-carriers-of-mrsa-a-randomized-and-placebo-controlled-clinical-trial
#6
Linda Björkhem-Bergman, Catharina Missailidis, John Karlsson-Valik, Ann Tammelin, Lena Ekström, Matteo Bottai, Ulf Hammar, Gudrun Lindh, Peter Bergman
Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to all beta-lactam antibiotics and can cause severe infections that are difficult to treat. Eradication strategies with conventional antibiotics are not always effective and alternative approaches are warranted. Here, we tested the hypothesis that daily supplementation with vitamin D for 12 months would reduce MRSA carriage rates among a group of persistent carriers. This was a double-blind, placebo-controlled randomized trial with n = 65 persistent MRSA carriers with 25-hydroxy vitamin D3 (25OHD) < 75 nmol/L, who were followed up with bacterial cultures at baseline and every 3 months for 1 year...
June 21, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29931588/low-level-laser-therapy-combined-to-functional-exercise-on-treatment-of-fibromyalgia-a-double-blind-randomized-clinical-trial
#7
Daniel Germano Maciel, Marianne Trajano da Silva, José Antônio Rodrigues, João Batista Viana Neto, Ingrid Martins de França, Ana Beatriz Medeiros Melo, Therence Yves Pereira Barros da Silva, Wouber Hérickson de Brito Vieira
This study aims to investigate the effects of low-level laser therapy (LLLT) combined to a functional exercise program on treatment of FM. A double-blind and placebo-controlled randomized clinical trial composed of 22 women divided into two groups: placebo group (functional exercise program associated with placebo phototherapy n = 11) and laser group (same exercise program associated with active phototherapy; n = 11). Each session lasted from 40 to 60 min and was performed three times a week for 8 weeks...
June 21, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29931459/effects-of-vitamin-d3-supplementation-on-muscle-strength-mass-and-physical-performance-in-women-with-vitamin-d-insufficiency-a-randomized-placebo-controlled-trial
#8
Lise Sofie Bislev, Lene Langagergaard Rødbro, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
Vitamin D insufficiency and hyperparathyroidism have been associated with reduced muscle strength, physical performance, postural stability, well-being, and quality of life. In a double-blinded, randomized placebo-controlled trial, we aimed to investigate effects of vitamin D3 supplementation on above-mentioned outcomes in healthy community-dwelling postmenopausal women with plasma levels of 25-hydroxyvitamin D (25(OH)D) below < 50 nmol/l and high parathyroid hormone (PTH) levels. Participants (N = 81) were 1:1 treated with vitamin D3, 70 µg (2800 IU)/day or identical placebo for three months during wintertime (56°N)...
June 21, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29931423/the-effects-of-probiotics-and-synbiotic-supplementation-on-glucose-and-insulin-metabolism-in-adults-with-prediabetes-a-double-blind-randomized-clinical-trial
#9
Nazila Kassaian, Awat Feizi, Ashraf Aminorroaya, Parvaneh Jafari, Maryam Tajabadi Ebrahimi, Masoud Amini
AIMS: Probiotics and/or prebiotics could be a promising approach to improve metabolic disorders by favorably modifying the gut microbial composition. OBJECTIVES: To assess the effects of probiotics and synbiotic on glycemic indices in prediabetic individuals who are at risk of type 2 diabetes and its complications. METHODS: In a double-blind, randomized, placebo-controlled parallel-group clinical trial, 120 prediabetic adults participated and were randomly allocated to receive either probiotics or synbiotic or placebo supplements for 24 weeks...
June 22, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29931320/a-dose-escalating-study-with-the-fetal-estrogen-estetrol-in-healthy-males
#10
Herjan J T Coelingh Bennink, Yvette Zimmerman, Carole Verhoeven, Alice E Dutman, Tjeert Mensinga, Cornelis Kluft, Yacov Reisman, Frans M J Debruyne
Context: Luteinizing hormone-releasing hormone (LHRH) agonists replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The fetal estrogen estetrol (E4) may be safer for PC treatment and is expected to decrease testosterone (T) and prevent estrogen deficiency. Objective: To investigate the safety and T suppressive effect of E4 in healthy males. Design: Double-blind, randomized, placebo-controlled, dose-escalating study...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29931216/a-phase-3-randomized-placebo-controlled-trial-to-evaluate-efficacy-and-safety-of-romosozumab-in-men-with-osteoporosis
#11
E Michael Lewiecki, Tomasz Blicharski, Stefan Goemaere, Kurt Lippuner, Paul D Meisner, Paul D Miller, Akimitsu Miyauchi, Judy Maddox, Li Chen, Stephane Horlait
Context: Globally, one in five men over 50 years of age is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and paucity of bone-forming agents for men, there is need for new osteoporosis treatments. Objective: Evaluate the safety and efficacy of romosozumab in men with osteoporosis. Design: Phase 3 randomized placeBo-contRolled double-blind study evaluatIng the efficacy anD safety of romosozumab in treatinG mEn with osteoporosis (BRIDGE; NCT02186171) for 12 months...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29931143/oxandrolone-treatment-results-in-an-increased-risk-of-gonadarche-in-prepubertal-boys-with-klinefelter-syndrome
#12
Shanlee M Davis, Najiba Lahlou, Matthew Cox-Martin, Karen Kowal, Philip S Zeitler, Judith L Ross
Context: Klinefelter syndrome (KS) is a common genetic condition in which males have an extra X chromosome. KS is associated with testosterone deficiency, neurodevelopmental delays, and cardiometabolic disorders. There has been recent interest in prepubertal androgen treatment, however the effects on puberty and gonadal function are unknown. Objective: To compare onset of puberty and testicular function in pre-pubertal boys treated with two years of oxandrolone versus placebo...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29931076/effect-of-adding-motolimod-to-standard-combination-chemotherapy-and-cetuximab-treatment-of-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-the-active8-randomized-clinical-trial
#13
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29930930/the-effect-of-atorvastatin-on-obsessive-compulsive-symptoms-of-refractory-obsessive-compulsive-disorder-add-on-therapy
#14
Shahla Akouchekian, Victoria Omranifard, Parivash Moshfegh, Mohammad Reza Maracy, Asiyeh Almasi
Background: Considering the effect of statins on the regulation of dopamine neurotransmitters and glutamates and importance of the treatment of obsessive-compulsive disorder (OCD) due to its relatively high prevalence and disability of available drugs in treatment of many patients, we came to the point to examine effectiveness of statins in patients with OCD. Materials and Methods: This study is a double-blind randomized clinical trial, which is done in OCD clinic of Isfahan Shariati in 2014 for 1 year...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29930141/role-of-endogenous-digitalis-like-factors-in-the-clinical-manifestations-of-severe-preeclampsia-a-sytematic-review
#15
REVIEW
Vardaman M Buckalew
Endogenous digitalis-like factor(s), originally proposed as a vasoconstrictor natriuretic hormone, was discovered in fetal and neonatal blood accidentally because it cross-reacts with antidigoxin antibodies (ADAs). Early studies using immunoassays with ADA identified the digoxin-like immuno-reactive factor(s) (EDLF) in maternal blood as well, and suggested it originated in the feto-placental unit. Mammalian digoxin-like factors have recently been identified as at least two classes of steroid compounds, plant derived ouabain (O), and several toad derived bufodienolides, most prominent being marinobufagenin (MBG)...
June 29, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29929990/nocturnal-blood-pressure-is-reduced-by-a-mandibular-advancement-device-for-sleep-apnea-in-women-findings-from-secondary-analyses-of-a-randomized-trial
#16
Helene Rietz, Karl A Franklin, Bo Carlberg, Carin Sahlin, Marie Marklund
BACKGROUND: Obstructive sleep apnea is associated with high blood pressure. The magnitude of blood pressure effects from sleep apnea treatment is unclear. We aimed to determine the effect of mandibular advancement device therapy on ambulatory nighttime and daytime blood pressure in women and men with daytime sleepiness and snoring or mild to moderate sleep apnea (apnea-hypopnea index, <30). METHODS AND RESULTS: In this 4-month, double-blind, randomized controlled trial comprising 96 untreated patients, 27 women and 58 men, aged 31 to 70 years, completed the study...
June 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29929813/botulinum-toxin-in-essential-hand-tremor-a-randomized-double-blind-placebo-controlled-study-with-customized-injection-approach
#17
Shivam Om Mittal, Duarte Machado, Diana Richardson, Divyanshu Dubey, Bahman Jabbari
INTRODUCTION: To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection for treatment of essential hand tremor. In essential tremor and Parkinson's disease tremor, administration of onabotulinumtoxinA via a fixed injection approach improves the tremor but a high percentage of patients (30-70%) develop moderate to severe hand weakness which has limited its use in clinical practice. METHODS: This study was performed from July 2013 to July 2016 on 33 subjects...
June 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29929783/safety-pharmacokinetics-and-immunogenicity-of-a-co-formulated-cocktail-of-three-human-monoclonal-antibodies-targeting-ebola-virus-glycoprotein-in-healthy-adults-a-randomised-first-in-human-phase-1-study
#18
Sumathi Sivapalasingam, Mohamed Kamal, Rabih Slim, Romana Hosain, Weiping Shao, Randall Stoltz, Joseph Yen, Laura G Pologe, Yuan Cao, Michael Partridge, Giane Sumner, Leah Lipsich
BACKGROUND: REGN3470-3471-3479 is a co-formulated cocktail of three human monoclonal antibodies targeting three non-overlapping epitopes on Ebola virus. We investigated safety, tolerability, pharmacokinetics, and anti-drug antibodies in healthy adults. METHODS: This randomised, double-blind, placebo-controlled, dose-escalation study was done at a phase 1 unit in the USA. Healthy adults, aged 18-60 years, with a body-mass index of 18·0-30·0 kg/m2 were randomly assigned (3:1) to receive a single intravenous dose of REGN3470-3471-3479 or placebo on day 1 (baseline) in one of the four sequential ascending intravenous dose cohorts (3 mg/kg, 15 mg/kg, 60 mg/kg, and 150 mg/kg)...
June 18, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29929537/aggression-following-traumatic-brain-injury-effectiveness-of-risperidone-after-study-protocol-for-a-feasibility-randomised-controlled-trial
#19
Shoumitro Deb, Verity Leeson, Lina Aimola, Mayur Bodani, Lucia Li, Tim Weaver, David Sharp, Mike Crawford
BACKGROUND: Traumatic brain injury (TBI) is a major public health concern and many people develop long-lasting physical and neuropsychiatric consequences following a TBI. Despite the emphasis on physical rehabilitation, it is the emotional and behavioural consequences that have greater impact on people with TBI and their families. One such problem behaviour is aggression which can be directed towards others, towards property or towards the self. Aggression is reported to be common after TBI (37-71%) and causes major stress for patients and their families...
June 21, 2018: Trials
https://www.readbyqxmd.com/read/29929533/dexmedetomidine-and-intravenous-acetaminophen-for-the-prevention-of-postoperative-delirium-following-cardiac-surgery-dexacet-trial-protocol-for-a-prospective-randomized-controlled-trial
#20
Puja Shankar, Ariel Mueller, Senthil Packiasabapathy, Doris Gasangwa, Melissa Patxot, Brian O'Gara, Shahzad Shaefi, Edward R Marcantonio, Balachundhar Subramaniam
BACKGROUND: Postoperative delirium is common in elderly cardiac surgery patients. It is multifactorial and is influenced by the patient's baseline status and the nature of the medical and surgical interventions that the patient receives. Some of these factors are potentially modifiable, including postoperative sedation and analgesia protocols. This study has been designed to evaluate the effectiveness of postoperative intravenous acetaminophen in conjunction with either dexmedetomidine or propofol in decreasing the incidence of delirium...
June 22, 2018: Trials
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