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https://www.readbyqxmd.com/read/29236049/effect-of-monthly-high-dose-long-term-vitamin-d-on-lung-function-a-randomized-controlled-trial
#1
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9-1.5 years), either (1) vitamin D₃ 200,000 IU, followed by monthly 100,000 IU doses (n = 226); or (2) placebo monthly (n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome)...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29235735/homemade-hypertonic-saline-essential-treatment-can-be-available-and-affordable
#2
Nili Elior, Diana Tasher, Elli Somekh, Michal Stein, Orna Schwartz Harari, Avigdor Mandelberg
BACKGROUND: Nebulized hypertonic saline (HS) treatment is unavailable to large populations worldwide. OBJECTIVES: To determine the bacterial contamination and electrolyte concentrations in homemade (HM-HS) vs. pharmacy made (PM-HS). METHODS: We conducted three double-blind consecutive trials: 50 boiled-water homemade 3%-HS (B-HM-HS) bottles and 50 PM-HS. The bottles were cultured after 48 hours. Electrolyte concentrations were measured in 10 bottles (5 per group)...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235186/improving-quit-rates-of-web-delivered-interventions-for-smoking-cessation-full-scale-randomized-trial-of-webquit-org-versus-smokefree-gov
#3
Jonathan B Bricker, Kristin E Mull, Jennifer B McClure, Noreen L Watson, Jaimee L Heffner
BACKGROUND AND AIMS: Millions of people worldwide use websites to help them quit smoking, but effectiveness trials have an average 34% follow-up data retention rate and an average 9% quit rate. We compared the quit rates of a website using a new behavioral approach called Acceptance and Commitment Therapy (ACT; WebQuit.org) with the current standard of the National Cancer Institute's (NCI) Smokefree.gov website. DESIGN: A two-arm stratified double-blind individually randomized trial (n = 1319 for WebQuit; n = 1318 for Smokefree...
December 13, 2017: Addiction
https://www.readbyqxmd.com/read/29235159/the-effect-of-green-tea-ointment-on-episiotomy-pain-and-wound-healing-in-primiparous-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Hadis Shahrahmani, Nourossadat Kariman, Sharareh Jannesari, Mahmoud Rafieian-Kopaei, Moghadameh Mirzaei, Sahar Ghalandari, Nasim Shahrahmani, Gashtasb Mardani
The delayed healing of episiotomy wound and its associated pain is a major problem in obstetrics. Because green tea has analgesic and wound-healing properties, the present study was conducted to determine the effect of green tea ointment on episiotomy pain and wound-healing. The green tea extract was also standardized by measuring its Phenolic and flavonoid compounds, antioxidant activity, and one of its active components, that is, Epigallocatechin gallate. The present clinical trial was conducted on 99 primiparous women visiting Afzalipour Hospital in Kerman in 2015...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29234869/a-controlled-trial-of-inhaled-bronchodilators-in-familial-dysautonomia
#5
Bat-El Bar-Aluma, Ori Efrati, Horacio Kaufmann, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann
BACKGROUND: Chronic lung disease is a leading cause of premature death in patients with familial dysautonomia (FD). A significant number of patients have obstructive airway disease, yet it is not known whether this is pharmacologically reversible. METHODS: We conducted a double-blind, placebo-controlled, randomized clinical trial comparing the beta 2 agonist albuterol with the muscarinic blocker ipratropium bromide in patients homozygous for the IKBKAP founder mutation...
December 12, 2017: Lung
https://www.readbyqxmd.com/read/29234752/morphological-and-immunophenotypical-differences-between-chronic-periodontitis-and-peri-implantitis-a-cross-sectional-study
#6
Pablo Galindo-Moreno, Jesús López-Martínez, Mercedes Caba-Molina, Rosa Ríos-Pelegrina, Laura Torrecillas-Martínez, Alberto Monje, Francisco Mesa, Natalia Chueca, Federico García-García, Francisco O'Valle
PURPOSE: To examine differences in morphology and in immunophenotype subsets between chronic periodontitis (CP) and peri-implantitis (P-I) lesions and to test the diagnostic agreement (CP vs P-I) among three independent observers, based on histopathological features. MATERIALS AND METHODS: This observational cross-sectional study included 15 gingival biopsies of CP lesions and 15 biopsies of P-I lesions for double-blinded examination by three independent pathologists...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234747/flapless-vs-flapped-implant-insertion-in-patients-with-controlled-type-2-diabetes-subjected-to-delayed-loading-1-year-follow-up-results-from-a-randomised-controlled-trial
#7
Kaushal Kishor Agrawal, Jitendra Rao, Mohd Anwar, Kalpana Singh, D Himanshu
PURPOSE: To compare the outcome of dental implants placed following full-thickness flap surgery with flapless surgery in controlled type 2 diabetic patients. MATERIALS AND METHODS: A total of 92 controlled type 2 diabetic patients, who needed missing mandibular first molars to be replaced by implants, were selected for a single-centre, parallel group, double-blinded randomised controlled trial. Patients were randomly allocated into two groups: flap (46 patients) vs flapless (46 patients) implant placement...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234725/computerized-cognitive-training-for-older-diabetic-adults-at-risk-of-dementia-study-protocol-for-a-randomized-controlled-trial
#8
Rachel Bloom, Michal Schnaider-Beeri, Ramit Ravona-Springer, Anthony Heymann, Hai Dabush, Lior Bar, Shirel Slater, Yuri Rassovsky, Alex Bahar-Fuchs
Introduction: Older adults with type 2 diabetes are at high risk of cognitive decline and dementia and form an important target group for dementia risk reduction studies. Despite evidence that computerized cognitive training (CCT) may benefit cognitive performance in cognitively healthy older adults and those with mild cognitive impairment, whether CCT may benefit cognitive performance or improve disease self-management in older diabetic adults has not been studied to date. In addition, whether adaptive difficulty levels and tailoring of interventions to individuals' cognitive profile are superior to generic training remains to be established...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29234530/a-prospective-randomised-double-blind-placebo-controlled-trial-to-assess-the-effect-of-diuretics-on-shockwave-lithotripsy-of-calculi
#9
Sagar Sabharwal, L Jeyaseelan, Arabind Panda, Lionel Gnanaraj, Nitin S Kekre, Antony Devasia
Objective: To assess the effect of diuretics with shockwave lithotripsy (SWL) on the treatment of renal and upper ureteric calculi. Patients and methods: Adult patients with a solitary non-obstructive radio-opaque renal or upper ureteric calculus with normal renal function were included. They were prospectively randomised to receive either SWL with placebo or SWL with diuretics (40 mg parenteral furosemide) in a double-blind manner with a sample size of 48 patients in each arm...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234523/amlodipine-vs-hydrochlorothiazide-is-there-any-disparity-in-its-antihypertensive-effect-or-not
#10
Venu Gopal Jonnalagadda, Kanchan Choudhary, Vijay Kranti Matety
We have read the article "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29234447/clinical-efficacy-and-safety-of-benjakul-remedy-extract-for-treating-primary-osteoarthritis-of-knee-compared-with-diclofenac-double-blind-randomized-controlled-trial
#11
Patamaporn Rachawat, Piya Pinsornsak, Puritat Kanokkangsadal, Arunporn Itharat
Background: The purpose of this study was to investigate the clinical efficacy and safety of Benjakul (BJK) extract for treating primary osteoarthritis (OA) of the knee compared with diclofenac. Methods: A phase 2, double blind, randomized, and controlled study was conducted. The BJK group received 300 mg of BJK extract per day, while another group received 75 mg of diclofenac per day. All patients were followed up at 14 and 28 days. The changing of visual analogue scale (VAS) for pain, 100-meter walking times, the modified Thai WOMAC index scores, and the global assessment were evaluated for efficacy...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234438/the-efficacy-of-acupuncture-on-anthropometric-measures-and-the-biochemical-markers-for-metabolic-syndrome-a-randomized-controlled-pilot-study
#12
Mingjuan Han, Yuxiu Sun, Wei Su, Shixi Huang, Sinuo Li, Mingyue Gao, Wenyan Wang, Fang Wang, Zhaohui Fang, Hong Zhao
Background: Many previous studies have shown the potential therapeutic effect of acupuncture for metabolic syndrome (MetS). However, most of these studies were limited by short durations of observation and a lack of sham acupuncture as control. We designed a randomized controlled trial, used sham acupuncture as the control, and evaluated the efficacy over 12 weeks of treatment and 12 weeks of follow-up. Methods/Design: The study was designed as a multicentre, parallel-group, randomized, double-blinded trial...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234428/network-pharmacology-based-approach-to-investigate-the-analgesic-efficacy-and-molecular-targets-of-xuangui-dropping-pill-for-treating-primary-dysmenorrhea
#13
Jihan Huang, Lei Li, Fan Cheung, Ning Wang, Yunfei Li, Zhenyu Fan, Fang Yin, Juan Yang, Rui Gao, Yingchun He, Yibin Feng
This study aimed to evaluate the clinical analgesic efficacy and identify the molecular targets of XGDP for treating primary dysmenorrhea (PD) by a network pharmacology approach. Analysis of pain disappearance rate of XGDP in PD treatment was conducted based on data from phase II and III randomized, double-blind, double-simulation, and positive parallel controlled clinical trials. The bioactive compounds were obtained by the absorption, distribution, metabolism, and excretion processes with oral bioavailability (OB) and drug-likeness (DL) evaluation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234255/influence-of-orally-administered-probiotic-lactobacillus-strains-on-vaginal-microbiota-in-women-with-breast-cancer-during-chemotherapy-a-randomized-placebo-controlled-double-blinded-pilot-study
#14
Julian Marschalek, Alex Farr, Marie-Louise Marschalek, Konrad J Domig, Wolfgang Kneifel, Christian F Singer, Herbert Kiss, Ljubomir Petricevic
Background: Due to chemotherapy and estrogen deprivation therapy, genitourinary syndrome of menopause is a common condition in breast cancer patients. We aimed to determine the effect of an orally administered Lactobacillus preparation on the vaginal microbiota in breast cancer patients. Methods: Postmenopausal breast cancer patients receiving chemotherapy, with vaginal atrophy and an intermediate vaginal microbiota (Nugent score 4-6), were either randomized to the intervention group receiving probiotic capsules of 4 Lactobacillus species or to the control group receiving placebo twice daily for 2 weeks...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29233792/n-acetylcysteine-supplementation-increases-exercise-performance-and-reduces-oxidative-stress-only-in-individuals-with-low-levels-of-glutathione
#15
Vassilis Paschalis, Anastasios A Theodorou, Nikos V Margaritelis, Antonios Kyparos, Michalis G Nikolaidis
Most of the evidence indicates that chronic antioxidant supplementation induces negative effects in healthy individuals. However, it is currently unknown whether specific redox deficiencies exist and whether targeted antioxidant interventions in deficient individuals can induce positive effects. We hypothesized that the effectiveness of antioxidant supplements to decrease oxidative stress and promote exercise performance depends on the redox status of the individuals that receive the antioxidant treatment. To this aim, we investigated whether N-acetylcysteine (NAC) supplementation would enhance exercise performance by increasing glutathione concentration and by reducing oxidative stress only in individuals with low resting levels of glutathione...
December 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29233260/tooth-whitening-evaluation-of-blue-covarine-containing-toothpastes
#16
Danying Tao, Richard N Smith, Qiong Zhang, Jianing N Sun, Carole J Philpotts, Stephen R Ricketts, Mojgan Naeeni, Andrew Joiner
OBJECTIVES: To measure the tooth whitening effects delivered immediately after brushing with silica-based toothpastes containing blue covarine in vitro and in vivo. METHODS: Salivary pellicle coated human extracted teeth were brushed with either a slurry of a toothpaste containing blue covarine (BC), a formulation containing an increased level of blue covarine (BC+) or a negative control toothpaste containing no blue covarine. The colour of the specimens were measured in vitro using either a Minolta chromameter or a VITA Easyshade spectrophotometer, before and after brushing and changes in CIELAB values and tooth Whiteness Index (WIO) values calculated...
December 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29232576/effects-of-oxytocin-on-cortisol-reactivity-and-conflict-resolution-behaviors-among-couples-with-substance-misuse
#17
Julianne C Flanagan, Melanie S Fischer, Paul J Nietert, Sudie E Back, Megan Moran-Santa Maria, Alexandra Snead, Kathleen T Brady
Social stress, particularly in the form of dyadic conflict, is a well-established correlate of substance use disorders (SUD). The neuropeptide oxytocin can enhance prosocial behavior and mitigate addictive behaviors. These effects may be, in part, a result of oxytocin's ability to attenuate hypothalamic-pituitary-adrenal (HPA) axis dysregulation. However, only one study to date has examined the effects of oxytocin on neuroendocrine reactivity or conflict resolution behavior among couples. Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29232560/the-effect-of-tranexamic-acid-and-gender-on-intraoperative-bleeding-in-orthognathic-surgery-a-randomized-controlled-trial
#18
Jesper Jared Secher, Johannes Jakobsen Sidelmann, Janne Ingerlsev, Jens Jørgen Thorn, Else Marie Pinholt
PURPOSE: The purpose of this randomized trial was to measure the effect of intravenously administered tranexamic acid (TXA) on intraoperative blood loss (IOB) in patients undergoing bimaxillary orthognathic surgery (OS). MATERIALS AND METHODS: The authors designed and implemented a double-blinded placebo-controlled trial composed of patients eligible for OS at the Hospital of South West Denmark (Esbjerg, Denmark) from August 2014 through September 2016. The primary predictor variable was a single intravenous dose of TXA 1 g administered preoperatively or an equivalent saline placebo...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29232214/the-comparison-between-effectiveness-of-ultrasound-guided-corticosteroid-injection-above-versus-below-the-median-nerve-in-mild-to-moderate-carpal-tunnel-syndrome-a-randomized-controlled-trial
#19
Arash Babaei-Ghazani, Nadere Nikbakht, Bijan Forogh, Gholam Reza Raissi, Tannaz Ahadi, Safoora Ebadi, Peyman Roomizadeh, Hamid Reza Fadavi, Seyed Ahmad Raeissadat, Bina Eftekharsadat
OBJECTIVE: In this study the clinical effectiveness of ultrasound-guided corticosteroid injection "above" versus "below" the median nerve for treatment of patients with mild to moderate carpal tunnel syndrome (CTS) was compared. DESIGN: This prospective randomized double-blind clinical trial included 44 patients with mild to moderate CTS. The subjects were randomly assigned to two groups to receive ultrasound-guided injection of 40 mg triamcinolone either "above" or "below" the involved median nerve...
December 11, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29231763/non-invasive-vagus-nerve-stimulation-for-the-acute-treatment-of-episodic-and-chronic-cluster-headache-a-randomized-double-blind-sham-controlled-act2-study
#20
Peter J Goadsby, Ilse F de Coo, Nicholas Silver, Alok Tyagi, Fayyaz Ahmed, Charly Gaul, Rigmor H Jensen, Hans-Christoph Diener, Kasia Solbach, Andreas Straube, Eric Liebler, Juana Ca Marin, Michel D Ferrari
Background Clinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH). Methods After completing a 1-week run-in period, subjects were randomly assigned (1:1) to receive nVNS or sham therapy during a 2-week double-blind period. The primary efficacy endpoint was the proportion of all treated attacks that achieved pain-free status within 15 minutes after treatment initiation, without rescue treatment...
January 1, 2017: Cephalalgia: An International Journal of Headache
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