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https://www.readbyqxmd.com/read/29037017/preoperative-chemoradiotherapy-versus-postoperative-chemoradiotherapy-for-stage-ii-iii-resectable-rectal-cancer-a-meta-analysis-of-randomized-controlled-trials
#1
Jin Ho Song, Jae Uk Jeong, Jong Hoon Lee, Sung Hwan Kim, Hyeon Min Cho, Jun Won Um, Hong Seok Jang
PURPOSE: Whether preoperative chemoradiotherapy (CRT) is better than postoperative CRT in oncologic outcome and toxicity is contentious in prospective randomized clinical trials. We systematically analyze and compare the treatment result, toxicity, and sphincter preservation rate between preoperative CRT and postoperative CRT in stage II-III rectal cancer. MATERIALS AND METHODS: We searched Medline, Embase, and Cochrane Library from 1990 to 2014 for relevant trials...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036866/the-prevalence-of-occupational-musculoskeletal-disorders-in-iran-a-meta-analysis-study
#2
Ayub Parno, Kourosh Sayehmiri, Mohsen Parno, Mohammad Khandan, Mohsen Poursadeghiyan, Maryam Maghsoudipour, Mohammad Hossein Ebrahimi
BACKGROUND: Prevention of Work-Related Musculoskeletal Disorders (WRMSDs) is crucial as they jeopardize the well-being of the workforce in workplaces and are prevalent in developed and developing countries. OBJECTIVE: This study aimed to determine the prevalence of WRMSDs among Iranian workers. METHODS: A systematic review and meta-analysis of WRMSDs in Iran was performed by searching relevant keywords in authentic databases and search engines such as SID, Google Scholar, Medlib and PubMed...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036834/association-between-sorl1-polymorphisms-and-the-risk-of-alzheimer-s-disease
#3
Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao
A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. The results show an increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, single nucleotide polymorphisms rs689021 was associated with a decreased risk in Caucasians, and single nucleotide polymorphisms rs641120 was detected as a decreased risk in both populations...
October 13, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29036723/converting-from-transdermal-to-buccal-formulations-of-buprenorphine-a-pharmacokinetic-meta-model-simulation-in-healthy-volunteers
#4
Tony Priestley, Arvind K Chappa, Diane R Mould, Richard N Upton, Neil Shusterman, Steven Passik, Vicente J Tormo, Stephen Camper
OBJECTIVE:  To develop a model to predict buprenorphine plasma concentrations during transition from transdermal to buccal administration. DESIGN:  Population pharmacokinetic model-based meta-analysis of published data. METHODS:  A model-based meta-analysis of available buprenorphine pharmacokinetic data in healthy adults, extracted as aggregate (mean) data from published literature, was performed to explore potential conversion from transdermal to buccal buprenorphine...
September 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036720/the-relationship-between-clinical-and-personal-recovery-in-patients-with-schizophrenia-spectrum-disorders-a-systematic-review-and-meta-analysis
#5
Robin Michael Van Eck, Thijs Jan Burger, Astrid Vellinga, Frederike Schirmbeck, Lieuwe de Haan
Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was performed to identify relevant studies. Correlation coefficients of the relationship between clinical and personal recovery were retrieved from primary studies. Meta-analyses were performed, calculating mean weighted effect sizes for the association between clinical and personal recovery, hope, and empowerment...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036523/stress-dependent-association-between-polygenic-risk-for-schizophrenia-and-schizotypal-traits-in-young-army-recruits
#6
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K Malhotra, Stella G Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C Stefanis
Schizotypal personality traits may increase proneness to psychosis and likely index familial vulnerability to schizophrenia (SZ), implying shared genetic determinants with SZ. Here, we sought to investigate the contribution of common genetic risk variation for SZ on self-reported schizotypy in 2 ethnically homogeneous cohorts of healthy young males during compulsory military service, enrolled in the Athens Study of Proneness and Incidence of Schizophrenia (ASPIS, N = 875) and the Learning on Genetics of Schizophrenia Spectrum study (LOGOS, N = 690)...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036426/clinical-outcome-of-patients-with-the-brugada-type-1-electrocardiogram-without-prophylactic-implantable-cardioverter-defibrillator-in-primary-prevention-a-cumulative-analysis-of-seven-large-prospective-studies
#7
Pietro Delise, Vincent Probst, Giuseppe Allocca, Nadir Sitta, Luigi Sciarra, Josep Brugada, Shiro Kamakura, Masahiko Takagi, Carla Giustetto, Leonardo Calo
Aims: Patients with the Brugada type 1 ECG (Br type 1) without previous aborted sudden death (aSD) who do not have a prophylactic ICD constitute a very large population whose outcome is little known. The objective of this study was to evaluate the risk of SD or aborted SD (aSD) in these patients. Methods and results: We conducted a meta-analysis and cumulative analysis of seven large prospective studies involving 1568 patients who had not received a prophylactic ICD in primary prevention...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036405/fold-a-method-to-optimize-power-in-meta-analysis-of-genetic-association-studies-with-overlapping-subjects
#8
Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han
Motivation: In genetic association studies, meta-analyses are widely used to increase the statistical power by aggregating information from multiple studies. In meta-analyses, participating studies often share the same individuals due to the shared use of publicly available control data or accidental recruiting of the same subjects. As such overlapping can inflate false positive rate, overlapping subjects are traditionally split in the studies prior to meta-analysis, which requires access to genotype data and is not always possible...
July 20, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036388/risk-factors-for-suicidality-in-patients-with-schizophrenia-a-systematic-review-meta-analysis-and-meta-regression-of-96-studies
#9
Ryan Michael Cassidy, Fang Yang, Flávio Kapczinski, Ives Cavalcante Passos
The lifetime risk of suicide and suicide attempt in patients with schizophrenia are 5% and 25%-50%, respectively. The current meta-analysis aims to determine risk factors associated with suicidality in subjects with schizophrenia. We searched Pubmed, Web of Science, EMBASE, and the reference lists of included studies. Inclusion criteria were met if an article reported a dichotomous sample of patients with schizophrenia with suicidal ideation, attempted suicide, or suicide compared to patients without. We also performed a cohort study meta-analysis as a supplemental analysis...
September 23, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036387/uncovering-exposures-responsible-for-birth-season-disease-effects-a-global-study
#10
Mary Regina Boland, Pradipta Parhi, Li Li, Riccardo Miotto, Robert Carroll, Usman Iqbal, Phung-Anh Alex Nguyen, Martijn Schuemie, Seng Chan You, Donahue Smith, Sean Mooney, Patrick Ryan, Yu-Chuan Jack Li, Rae Woong Park, Josh Denny, Joel T Dudley, George Hripcsak, Pierre Gentine, Nicholas P Tatonetti
Objective: Birth month and climate impact lifetime disease risk, while the underlying exposures remain largely elusive. We seek to uncover distal risk factors underlying these relationships by probing the relationship between global exposure variance and disease risk variance by birth season. Material and Methods: This study utilizes electronic health record data from 6 sites representing 10.5 million individuals in 3 countries (United States, South Korea, and Taiwan)...
September 28, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036312/safety-and-efficacy-of-cryoablation-vs-radiofrequency-ablation-of-septal-accessory-pathways-systematic-review-of-the-literature-and-meta-analyses
#11
Loreto Bravo, Felipe Atienza, Gabriel Eidelman, Pablo Ávila, Mauricio Pelliza, Evaristo Castellanos, Gerard Loughlin, Tomás Datino, Esteban G Torrecilla, Jesús Almendral, Pedro Luis Sánchez, Ángel Arenal, Nieves Martínez-Alzamora, Francisco Fernández-Avilés
Aims: Radiofrequency ablation (RFA) of septal accessory pathways (APs) is associated with a significant rate of first procedure failures and complications. Cryoablation is an alternative energy source but there are no studies comparing both ablation techniques. We aimed to systematically review the literature and compare the efficacy and safety of cryoablation vs. RFA of septal APs. Methods and results: We conducted two separate meta-analysis of cryoablation and RFA of septal APs and calculated the global estimates of the efficacy and safety...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036216/herpesviruses-in-etiopathogenesis-of-aggressive-periodontitis-a-meta-analysis-based-on-case-control-studies
#12
Fei Li, Ce Zhu, Feng-Ying Deng, May Chun Mei Wong, Hai-Xia Lu, Xi-Ping Feng
OBJECTIVE: Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. METHODS: We identified eligible case-control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated...
2017: PloS One
https://www.readbyqxmd.com/read/29036199/the-acute-physiological-stress-response-to-driving-a-systematic-review
#13
Michael Antoun, Kate M Edwards, Joanna Sweeting, Ding Ding
BACKGROUND: The experience of driving has been suggested to be detrimental to health. One hypothesis is that each exposure elicits an acute stress response, and that repeated exposures may act as a chronic stressor. OBJECTIVE: The aim of this review is to evaluate and synthesise the evidence on whether driving elicits an acute physiological stress response. METHODS: Electronic databases, including CINAHL, PsycINFO and Medline, were searched for original articles written in English from database inception until March 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29036173/pre-treatment-with-gnrha-or-ulipristal-acetate-prior-to-laparoscopic-and-laparotomic-myomectomy-a-systematic-review-and-meta-analysis
#14
Inge de Milliano, Moniek Twisk, Johannes C Ket, Judith A Huirne, Wouter J Hehenkamp
BACKGROUND: Myomectomy has potential risks of complications. To reduce these risks, medical pre-treatment can be applied to reduce fibroid size and thereby potentially decrease intra-operative blood loss, the need for blood transfusion and emergency hysterectomy. The aim of this systematic review and meta-analysis is to study the effectiveness of medical pre-treatment with Gonadotropin-releasing hormone agonists (GnRHa) or ulipristal acetate prior to laparoscopic or laparotomic myomectomy on intra-operative and post-operative outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/29035966/effectiveness-of-rifampicin-chemoprophylaxis-in-preventing-leprosy-in-patient-contacts-a-systematic-review-of-quantitative-and-qualitative-evidence
#15
Silvana Margarida Benevides Ferreira, Tatiana Yonekura, Eliane Ignotti, Larissa Bertacchini de Oliveira, Juliana Takahashi, Cassia Baldini Soares
BACKGROUND: Individuals in contact with patients who have leprosy have an increased risk of disease exposure, which reinforces the need for chemoprophylactic measures, such as the use of rifampicin. OBJECTIVES: The objective of the review was to synthesize the best available evidence regarding the effectiveness of rifampicin chemoprophylaxis for contacts with patients with leprosy, and to synthesize the best available evidence on the experience and acceptability of rifampicin chemoprophylaxis as reported by the contacts and health professionals involved in the treatment of leprosy or Hansen's disease...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035964/medication-safety-programs-in-primary-care-a-scoping-review
#16
Hanan Khalil, Monica Shahid, Libby Roughead
BACKGROUND: Medication safety plays an essential role in all healthcare organizations; improving this area is paramount to quality and safety of any wider healthcare program. While several medication safety programs in the hospital setting have been described and the associated impact on patient safety evaluated, no systematic reviews have described the impact of medication safety programs in the primary care setting. A preliminary search of the literature demonstrated that no systematic reviews, meta-analysis or scoping reviews have reported on medication safety programs in primary care; instead they have focused on specific interventions such as medication reconciliation or computerized physician order entry...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035943/metabolic-syndrome-and-subclinical-carotid-damage-a-meta-analysis-from-population-based-studies
#17
Cesare Cuspidi, Carla Sala, Fabio Provenzano, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: Metabolic syndrome (MetS) is a phenotype of growing prevalence in the general population. Information on the association between MetS and vascular damage in this setting is only based on data provided by single reports. We performed a meta-analysis of population-based studies aimed to assess the association of MetS with carotid atherosclerosis. DESIGN: Studies were identified by the following search terms: 'metabolic syndrome', 'general population,' 'carotid intima-media thickness' (IMT), 'carotid atherosclerosis,' 'carotid damage,' 'ultrasonography...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035801/systematic-review-with-meta-analysis-performance-of-dried-blood-spots-for-hepatitis-c%C3%A2-antibodies-detection
#18
REVIEW
B A Muzembo, N C Mbendi, S F Nakayama
OBJECTIVES: Dried blood spots (DBS) specimens can be used for hepatitis C virus (HCV) infection screening in cases where serum specimens are difficult to obtain. However, uncertainties surround the sensitivity and specificity of DBS for HCV antibodies (anti-HCV) serology testing. We aimed to evaluate the accuracy of DBS use to screen for HCV infection. STUDY DESIGN: We carried out a systematic review and meta-analysis. METHODS: Medline and EMBASE databases were searched for articles published between 1989 and November 2016...
October 13, 2017: Public Health
https://www.readbyqxmd.com/read/29035643/role-of-bone-modifying-agents-in-metastatic-breast-cancer-an-american-society-of-clinical-oncology-cancer-care-ontario-focused-guideline-update
#19
Catherine Van Poznak, Mark R Somerfield, William E Barlow, J Sybil Biermann, Linda D Bosserman, Mark J Clemons, Sukhbinder K Dhesy-Thind, Melissa S Dillmon, Andrea Eisen, Elizabeth S Frank, Reshma Jagsi, Rachel Jimenez, Richard L Theriault, Theodore A Vandenberg, Gary C Yee, Beverly Moy
Purpose To update, in collaboration with Cancer Care Ontario (CCO), key recommendations of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-modifying agents (BMAs) in metastatic breast cancer. This focused update addressed the new data on intervals between dosing and the role of BMAs in control of bone pain. Methods A joint ASCO-CCO Update Committee conducted targeted systematic literature reviews to identify relevant studies. Results The Update Committee reviewed three phase III noninferiority trials of dosing intervals, one systematic review and meta-analysis of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary to bone metastases...
October 16, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29035454/the-relationship-between-mdm2-t309g-polymorphism-and-leukemia-in-the-chinese-population-evidence-from-a-meta-analysis
#20
Dewan Zhao, Ting Liu
BACKGROUND: Increasing numbers of studies have been carried out on the association of MDM2 T309G polymorphism with susceptibility to leukemia and have generated conflicting results. This meta-analysis updated and revaluated the possible associations between MDM2 T309G polymorphism and leukemia in the Chinese population. METHODS: The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine were searched up to February 2017...
October 1, 2017: Clinical Laboratory
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