Anelise S Carlessi, Maria Eduarda M Botelho, Luana M Manosso, Laura A Borba, Larissa R Maciel, Natalia M Andrade, Nicoly S Martinello, Alex Paulo Z Padilha, Camille M Generoso, Clara Vitória Bencke, Airam B de Moura, Bruna F Lodetti, Allan Collodel, Larissa Joaquim, Sandra Bonfante, Erica Biehl, Jaqueline S Generoso, Camila O Arent, Tatiana Barichello, Fabricia Petronilho, João Quevedo, Gislaine Z Réus
Major depressive disorder (MDD) is the most prevalent mood disorder globally. Most antidepressants available for the treatment of MDD increase the concentration of monoamines in the synaptic cleft. However, such drugs have a high latency time to obtain benefits. Thus, new antidepressants with fast action and robust efficacy are very important. This study evaluated the effects of escitalopram, ketamine, and probiotic Bifidobacterium infantis in rats submitted to the maternal deprivation (MD). MD rats received saline, escitalopram, ketamine, or probiotic for 10, 30, or 50 days, depending on the postnatal day (PND):21, 41, and 61...
September 26, 2022: Pharmacology, Biochemistry, and Behavior