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https://www.readbyqxmd.com/read/29778840/identification-of-a-novel-promoter-from-banana-aquaporin-family-gene-matip1-2-which-responses-to-drought-and-salt-stress-in-transgenic-arabidopsis-thaliana
#1
Shun Song, Yi Xu, Dongmei Huang, Hongxia Miao, Juhua Liu, Caihong Jia, Wei Hu, Ana Valeria Valarezo, Biyu Xu, Zhiqiang Jin
Drought and salt stresses often affect plant growth and crop yields. Identification of promoters involved in drought and salt stress responses is of great significance for genetic improvement of crop resistance. Our previous studies showed that aquaporin can respond to drought and salt stresses, but its promoter has not yet been reported in plants. In the present study, cis-acting elements of MaAQP family member promoters were systematically analyzed in banana. Expression of MaTIP1; 2 was induced by drought and salt stresses but not sensitive to cold stress, waterlogging stress, or mechanical damage, and its promoter contained five stress-related cis-acting elements...
May 17, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#2
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29572776/exome-sequencing-confirms-molecular-diagnoses-in-38-chinese-families-with-hereditary-spherocytosis
#3
Rongrong Wang, Shuanghao Yang, Ming Xu, Jia Huang, Hongyan Liu, Weiyue Gu, Xue Zhang
Hereditary spherocytosis (HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes (ANK1, SPTB, SPTA1, SLC4A1, and EPB42) have been identified. To date, molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families...
March 19, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29457995/translation-and-validation-of-the-transition-readiness-assessment-questionnaire-traq
#4
Catherine G Anelli, Claudio A Len, Maria Teresa R A Terreri, Gleice C S Russo, Andreas O Reiff
OBJECTIVE: To translate and validate the Brazilian Portuguese version of the Transition Readiness Assessment Questionnaire in a population of adolescents and young adults with chronic rheumatologic disorders. This questionnaire evaluates the patient's readiness for making the transition from the pediatric health service to adult care. METHODS: The four-phase methodology for the translation and validation of generic questionnaires was followed, including translation, back-translation, pilot testing and clinical validation of the final tool...
February 16, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/28931021/zoonotic-infection-of-brazilian-primate-workers-with-new-world-simian-foamy-virus
#5
Cláudia P Muniz, Liliane T F Cavalcante, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Anderson M Augusto, Alcides Pissinatti, Luiz P Fedullo, André F Santos, Marcelo A Soares, William M Switzer
Simian foamy viruses (SFVs) are retroviruses present in nearly all nonhuman primates (NHPs), including Old World primates (OWP) and New World primates (NWP). While all confirmed human infections with SFV are from zoonotic transmissions originating from OWP, little is known about the zoonotic transmission potential of NWP SFV. We conducted a longitudinal, prospective study of 56 workers occupationally exposed to NWP in Brazil. Plasma from these workers was tested using Western blot (WB) assays containing NWP SFV antigens...
2017: PloS One
https://www.readbyqxmd.com/read/28910353/reference-equations-for-the-six-minute-walk-distance-in-the-healthy-chinese-population-aged-18-59-years
#6
COMPARATIVE STUDY
He Zou, Xiuruo Zhu, Jia Zhang, Yi Wang, Xiaozhen Wu, Fang Liu, Xiaofeng Xie, Xiaoshu Chen
BACKGROUND: The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity of patients with chronic respiratory disease. However, there is a lack of standard reference equations for the six-minute walk distance (6MWD) in the healthy Chinese population aged 18-59 years. AIMS: The purposes of the present study were as follows: 1) to measure the anthropometric data and walking distance of a sample of healthy Chinese Han people aged 18-59 years; 2) to construct reference equations for the 6MWD; 3) to compare the measured 6MWD with previously published equations...
2017: PloS One
https://www.readbyqxmd.com/read/28851335/reference-equations-for-the-six-minute-walk-distance-in-the-healthy-chinese-han-population-aged-18-30-years
#7
He Zou, Jia Zhang, Xiaoshu Chen, Yi Wang, Wei Lin, Jianfeng Lin, Hao Chen, Jingye Pan
BACKGROUND: The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity. However, there is a lack of standard reference equations for the six-minute walk distance (6MWD) in the healthy Chinese Han population with an age of 18-30 years. The aims of the present study were as follows: 1) to measure the anthropometric data and the walking distance in a sample of healthy Chinese Han population, aged 18-30 years; 2) to construct reference equations for the 6MWD; 3) to compare the measured 6MWD of our cohort with previously published equations...
August 29, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28767592/bmp4-rs17563-polymorphism-and-nonsyndromic-cleft-lip-with-or-without-cleft-palate-a-meta-analysis
#8
Yue-Hua Li, Jiaomei Yang, Ju-Lei Zhang, Jia-Qi Liu, Zhao Zheng, Da-Hai Hu
BACKGROUND: Previous studies have investigated the relationship between human bone morphogenetic protein 4 gene (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, the results remained inconsistent. Therefore, we conducted a meta-analysis to assess the effect of BMP4 rs17563 polymorphism on NSCL/P. METHODS: Electronic searches in 5 databases were conducted to select all eligible studies up to March 2017. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated to estimate the association...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28412076/varicella-vaccination-elicits-a-humoral-and-cellular-response-in-children-with-rheumatic-diseases-using-immune-suppressive-treatment
#9
Noortje Groot, Gecilmara Pileggi, Cleonice B Sandoval, Ingrid Grein, Guy Berbers, Virginia Paes Leme Ferriani, Nico Wulffraat, Sytze de Roock
OBJECTIVE: To assess humoral and cellular responses to live-attenuated varicella zoster virus (VZV) vaccination of patients with juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM) or juvenile scleroderma (JScle) compared to those of healthy controls (HC). METHODS: Before, 4-6weeks and one year after VZV vaccination, blood samples of patients and HC were collected. VZV-specific antibody concentrations were measured by ELISA and multiplex immune-assay...
May 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28299979/artepillin-c-is-it-a-good-marker-for-quality-control-of-brazilian-green-propolis
#10
Cui-Ping Zhang, Xiao-Ge Shen, Jia-Wei Chen, Xia-Sen Jiang, Kai Wang, Fu-Liang Hu
As commercialisation of Brazilian green propolis is going on, quality evaluation and authenticity are important. The result demonstrated that artepillin C found by far in Brazilian green propolis by HPLC-ESI-MS/MS analysis, while a small interferent may be mistaken as artepillin C in some propolis from China. A new HPLC quality control method as artepillin C for marker was developed, which is the primary assessment criteria for quality control of Brazilian green propolis.
March 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/27692000/frequency-of-autoimmune-disorders-and-autoantibodies-in-patients-with-neuromyelitis-optica
#11
Wildéa Lice de Carvalho Jennings Pereira, Edna Maria Vissoci Reiche, Ana Paula Kallaur, Sayonara Rangel Oliveira, Andréa Name Colado Simão, Marcell Alysson Batisti Lozovoy, Lucas José Vaz Schiavão, Paula Raquel do Vale Pascoal Rodrigues, Daniela Frizon Alfieri, Tamires Flauzino, Damacio Ramón Kaimen-Maciel
OBJECTIVE: The aim of this study was to report the frequency of autoimmune disorders and autoantibodies in 22 patients with neuromyelitis optica (NMO), as well as whether the seropositivity for autoantibodies differs between anti-aquaporin 4 (AQP4) positive and AQP4 negative NMO patients. METHODS: Demographic, medical records, and a profile of autoantibodies were evaluated in 22 NMO patients, including AQP4, anti-thyroid-stimulating hormone receptor, antinuclear antibodies (ANA), anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (anti-Tg), anti-double-stranded DNA, anti-neutrophil cytoplasmic, anti-cyclic citrullinate peptide, rheumatoid factor, anti-SSA/Ro, anti-SSB/La, anti-Smith antibodies (anti-Sm), anti-ribonucleoprotein, anti-nucleosome, and anti-Scl70...
June 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27208805/frequency-of-the-ccr5-delta32-allele-in-brazilian-populations-a-systematic-literature-review-and-meta-analysis
#12
REVIEW
Wlisses Henrique Veloso Silva-Carvalho, Ronald Rodrigues de Moura, Antonio Victor Campos Coelho, Sergio Crovella, Rafael Lima Guimarães
The CCR5 is a chemokine receptor widely expressed by several immune cells that are engaged in inflammatory responses. Some populations have individuals exhibiting a 32bp deletion in the CCR5 gene (CCR5-delta32) that produces a truncated non-functional protein not expressed on the cell surface. This polymorphism, known to be associated with susceptibility to infectious and inflammatory diseases, such as osteomyelitis, pre-eclampsia, systemic lupus erythematous, juvenile idiopathic arthritis, rheumatoid arthritis and HIV/AIDS, is more commonly found in European populations with average frequency of 10%...
September 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27119012/studies-using-ips-cells-support-a-possible-link-between-zika-and-microcephaly
#13
Jia Guo
There is a suspected link between Brazilian babies born with microcephaly and Zika virus (ZIKV) infection. However, little is know about the brain cell targets and the mechanisms that Zika virus may cause microcephaly. A recent report demonstrated that Zika virus infection increases cell death and dysregulates cell-cycle, resulting in attenuated human neural progenitor cells growth. This study fills a major gap and serves as an entry point to establish a mechanistic link between Zika infection and microcephaly...
2016: Cell & Bioscience
https://www.readbyqxmd.com/read/26560983/incidence-of-active-mycobacterial-infections-in-brazilian-patients-with-chronic-inflammatory-arthritis-and-negative-evaluation-for-latent-tuberculosis-infection-at-baseline-a-longitudinal-analysis-after-using-tnfa-blockers
#14
Carina Mori Frade Gomes, Maria Teresa Terreri, Maria Isabel de Moraes-Pinto, Cássia Barbosa, Natália Pereira Machado, Maria Roberta Melo, Marcelo Medeiros Pinheiro
Several studies point to the increased risk of reactivation of latent tuberculosis infection (LTBI) in patients with chronic inflammatory arthritis (CIAs) after using tumour necrosis factor (TNF)a blockers. To study the incidence of active mycobacterial infections (aMI) in patients starting TNFa blockers, 262 patients were included in this study: 109 with rheumatoid arthritis (RA), 93 with ankylosing spondylitis (AS), 44 with juvenile idiopathic arthritis (JIA) and 16 with psoriatic arthritis (PsA). All patients had indication for anti-TNFa therapy...
November 2015: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/26255878/oral-health-and-quality-of-life-of-children-and-adolescents-with-juvenile-idiopathic-arthritis-according-to-their-caregivers-perceptions
#15
Débora Santos, Carlos Silva, Marlete Silva
The aim of this study was to assess the correlation between oral health indicators and oral health-related quality of life (OHRQoL) of children and adolescents with juvenile idiopathic arthritis (JIA) according to their caregivers' perceptions. Parents or guardians (mean age, 40.6 years; standard deviation [SD] = 10.97 years) of children and adolescents with JIA (n = 17; mean age, 9.8 years; SD = 2.86) and parents or guardians of healthy children and adolescents (n = 15; mean age, 10.7 years; SD = 2.16) filled the short form of the Brazilian Parental-Caregiver Questionnaire (SF: 13 - B-PCPQ)...
November 2015: Special Care in Dentistry
https://www.readbyqxmd.com/read/25936608/recommendations-on-the-use-of-biosimilars-by-the-brazilian-society-of-rheumatology-brazilian-society-of-dermatology-brazilian-federation-of-gastroenterology-and-brazilian-study-group-on-inflammatory-bowel-disease-focus-on-clinical-evaluation-of-monoclonal-antibodies
#16
REVIEW
Valderílio Feijó Azevedo, Eduardo de Souza Meirelles, Jussara de Almeida Lima Kochen, Ana Cristina Medeiros, Sender J Miszputen, Fábio Vieira Teixeira, Adérson Osmar Mourão Cintra Damião, Paulo Gustavo Kotze, Ricardo Romiti, Marcelo Arnone, Renata Ferreira Magalhães, Cláudia Pires Amaral Maia, André Vicente E de Carvalho
The Brazilian Societies of Rheumatology (SBR) and Dermatology (SBD), the Brazilian Federation of Gastroenterology (FBG) and the Brazilian Study Group on Inflammatory Bowel Disease (GEDIIB) gathered a group of their respective specialists on the topic of interest to discuss the most relevant issues regarding the clinical use of biosimilar medicines in Brazil. The main aim of that meeting was to prepare a document with recommendations to guide medical specialists and to help the national regulatory and policy-making agencies as concerns the authorization for marketing biosimilars used in autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, juvenile idiopathic arthritis and ulcerative colitis...
September 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/25554729/dsrna-binding-protein-pact-rax-in-gene-silencing-development-and-diseases
#17
Yue Yong, Jia Luo, Zun-Ji Ke
PACT (Protein kinase, interferon-inducible double stranded RNA dependent activator) and its murine ortholog RAX (PKR-associated protein X) were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase (PKR). Endogenous PACT/RAX activates PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment. PACT/RAX heterodimerized with PKR and activated it with its third motif in the absence of dsRNA. The activation of PKR leads to enhanced eIF2α phosphorylation followed by apoptosis or inhibition of growth...
October 2014: Frontiers in Biology
https://www.readbyqxmd.com/read/25213651/microbiota-of-the-major-south-atlantic-reef-building-coral-mussismilia
#18
Samodha C Fernando, Jia Wang, Kimberly Sparling, Gizele D Garcia, Ronaldo B Francini-Filho, Rodrigo L de Moura, Rodolfo Paranhos, Fabiano L Thompson, Janelle R Thompson
The Brazilian endemic scleractinian corals, genus Mussismilia, are among the main reef builders of the South Atlantic and are threatened by accelerating rates of disease. To better understand how holobiont microbial populations interact with corals during health and disease and to evaluate whether selective pressures in the holobiont or neutral assembly shape microbial composition, we have examined the microbiota structure of Mussismilia corals according to coral lineage, environment, and disease/health status...
February 2015: Microbial Ecology
https://www.readbyqxmd.com/read/24941921/fatigue-in-children-with-juvenile-idiopathic-arthritis-reliability-of-the-pediatric-quality-of-life-inventory-multidimensional-fatigue-scale
#19
Luciana Tudech S P Paulo, Claudio A Len, Maria Odete E Hilario, Soraya A Pedroso, Maria Sylvia S Vitalle, Maria Teresa Terreri
The aim of the study was (1) to translate the "Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale" (PedsQL-Fatigue) into Brazilian Portuguese language and culture and evaluate its reliability and (2) to measure fatigue among patients with juvenile idiopathic arthritis (JIA): (1) Translation of the PedsQL-Fatigue by two bilingual researchers; (2) Backtranslation into English assessed by the authors of the original version; (3) Pilot study with five patients followed in the Pediatric Rheumatology Outpatient Clinic and their parents; and (4) Field study and assessment of measurement properties (internal consistency, reproducibility, and construct validity)...
January 2015: Rheumatology International
https://www.readbyqxmd.com/read/24651918/anti-ccp-antibodies-in-brazilian-children-and-adults-with-juvenile-idiopathic-arthritis
#20
S Bacos, S G Bortolozzi, T S Skare, P F Spelling, S R R Utiyama, R Nisihara
Patients with juvenile idiopathic arthritis (JIA) may need further care in the adult clinic as this disease frequently has continuous inflammatory activity during adult life. To identify which pediatric JIA patients will need continuing care into adulthood. We compared the clinical, serological, and demographic data of 45 JIA patients followed up by the pediatric clinic to those of 49 JIA patients in the adult rheumatology clinic. Patients in the adult clinic have older age at disease onset (p < 0.0001) and higher prevalence of positive anti-cyclic citrullinated peptide (CCP) (p = 0...
July 2014: Clinical Rheumatology
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