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https://www.readbyqxmd.com/read/28539973/are-ultrasound-features-at-the-first-metatarsophalangeal-joint-associated-with-clinically-assessed-pain-and-function-a-study-of-people-with-gout-asymptomatic-hyperuricaemia-and-normouricaemia
#1
Sarah Stewart, Nicola Dalbeth, Alain C Vandal, Bruce Allen, Rhian Miranda, Keith Rome
BACKGROUND: The first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. However, it is unclear whether these are related to clinically-assessed pain and function. This study aimed to determine the association between ultrasound features and clinical characteristics of the 1st MTP joint in people with gout, asymptomatic hyperuricaemia and age- and sex-matched normouricaemic individuals...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28533851/-giant-cell-tumors-of-the-tendon-sheaths-of-the-hand-about-50-cases
#2
Walid Osman, Zeineb Alaya, Ali Haggui, Mohamed Ben Rejeb, Sonia Jemni, Nader Naouar, Mohamed Laziz Ben Ayeche
Giant cell tumors of the synovial tendon sheaths (GCTSTS) are a localized form of hemopigmented villonodular synovitis. They mainly affect the hands. This study aims to analyse the epidemiology, clinical and therapeutic characteristics of GCTSTS, to assess the results of surgical treatment and to identify risk factors for recurrences. We conducted a retrospective data collection from medical records of 50 patients with GCTSTS of the hand between 1992 and 2016 in the Department of Orthopaedics at the Hospital of Sahloul (Sousse-Tunisia)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28532514/course-of-serum-amyloid-a-saa-plasma-concentrations-in-horses-undergoing-surgery-for-injuries-penetrating-synovial-structures-an-observational-clinical-study
#3
Eva Haltmayer, Ilse Schwendenwein, Theresia F Licka
BACKGROUND: Injuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious conditions in horses including wounds and septic arthritis. Plasma SAA levels were found to decrease rapidly once the infectious stimulus was eliminated. The purpose of the current study was to investigate the usefulness of serial measurements of plasma SAA as a monitoring tool for the response to treatment of horses presented with injuries penetrating synovial structures...
May 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28521689/relationship-between-rheumatoid-arthritis-disease-activity-assessed-with-the-us7-score-and-quality-of-life-measured-with-questionnaires-haq-eq-5d-wpai
#4
Martina Skácelová, Skácelová Martina, Horák Pavel, Heřmanová Zuzana, Langová Kateřina
BACKGROUND: Rheumatoid arthritis is a chronic disease considerably affecting the quality of life of patients, their functional abilities and capability to work. In everyday clinical practice, the condition is commonly monitored by assessing the disease activity using a joint count and laboratory markers of inflammation with calculating the DAS28 or other systems for scoring the disease activity. OBJECTIVES: This study is aimed to evaluate the benefit of ultrasound examination with a standardized instrument and correlate its results with the quality of life of patients and their functional abilities as assessed by standardized questionnaire methods...
May 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28516887/tenosynovitis-in-rheumatoid-arthritis-patients-on-biologic-treatment-involvement-and-sensitivity-to-change-compared-to-joint-inflammation
#5
Hilde Berner Hammer, Tore K Kvien, Lene Terslev
OBJECTIVES: Extensor carpi ulnaris (ECU) and tibialis posterior (TP) tendons are often involved in RA and the present aim was to examine by ultrasound (US) their frequency of inflammation and sensitivity to change in comparison to joint involvement as well as clinical examinations. METHODS: US, clinical and laboratory assessments were performed when starting biologic DMARD (bDMARD) and after 1, 2, 3, 6 and 12 months including bilateral grey-scale (GS) and power Doppler (PD) semi-quantitatively (0-3) scoring of ECU and TP tendons and 18 joints...
May 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516447/metacarpophalangeal-joint-injury-patterns-on-magnetic-resonance-imaging-a-comparison-in-racing-standardbreds-and-thoroughbreds
#6
Julien Olive, Nicolas Serraud, Thibault Vila, Jean-Philippe Germain
The metacarpal condyle has received extensive attention as a predominant site of overload arthropathy in racehorses. However, detailed descriptions of MRI lesion patterns for the metacarpophalangeal joint and comparisons between types of racing horses are currently lacking. Aims of this retrospective, cross-sectional study were to describe and compare standing low-field magnetic resonance findings in the metacarpophalangeal joints for groups of Standardbreds and Thoroughbreds using systematic semiquantitative scores...
May 17, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28514501/intraarticular-capacity-of-the-elbow-joint
#7
Mathias van den Broek, Roger van Riet
INTRODUCTION: The intraarticular capacity of the elbow joint is reported to be 23 ± 4ml on cadaveric elbows. During years, this value was the standard. The aim of this observational study was to reanalyze the volume of the elbow joint on live patients. MATERIALS AND METHODS: Measurement of the intraarticular capacity and pressure of the elbow joint was performed on 30 patients (mean age: 43.8 years) undergoing elbow arthroscopy. Intra-articular capacity was recorded when the elbow moved to the maximum lose packed position and/or when there was a sudden drop in pressure, indicating a capsular rupture (maximum capacity)...
May 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28513840/histomorphology-and-innate-immunity-during-the-progression-of-osteoarthritis-does-synovitis-affect-cartilage-degradation
#8
Huan Wang, Qingguo Wang, Meijuan Yang, Lili Yang, Weili Wang, Haobin Ding, Dong Zhang, Jing Xu, Xuezhang Tang, Haitao Ding, Qingfu Wang
Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological stages of the disease. In the present study, our aim was to assess changes in innate immunity during the pathological processes of OA in articular cartilage (AC) and the synovial membrane (SM), which are the major structures in joints, and to systematically examine the histological changes in AC and SM in mild, moderate and severe cases of OA, in order to further speculate about the manner in which the interactions of AC and SM are facilitated by innate immunity...
May 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28510679/effect-of-intra-articular-triamcinolone-vs-saline-on-knee-cartilage-volume-and-pain-in-patients-with-knee-osteoarthritis-a-randomized-clinical-trial
#9
Timothy E McAlindon, Michael P LaValley, William F Harvey, Lori Lyn Price, Jeffrey B Driban, Ming Zhang, Robert J Ward
Importance: Synovitis is common and is associated with progression of structural characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage damage associated with synovitis but might have adverse effects on cartilage and periarticular bone. Objective: To determine the effects of intra-articular injection of 40 mg of triamcinolone acetonide every 3 months on progression of cartilage loss and knee pain. Design, Setting, and Participants: Two-year, randomized, placebo-controlled, double-blind trial of intra-articular triamcinolone vs saline for symptomatic knee osteoarthritis with ultrasonic features of synovitis in 140 patients...
May 16, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28507977/a-sub-acute-septic-arthritis-of-the-knee-a-sequelae-to-thorn-prick-injury-of-patella-a-case-report
#10
R Sivakumar, Prahalad Kumar Singhi, M Chidambaram, V Somashekar, Vinoth Thangamani
INTRODUCTION: Sub-acute septic arthritis of knee following a thorn prick injury to patella is an uncommon condition and seen in active playful children. The child may be afraid to narrate the incident to their parents or examining doctor, so a high index of suspicion is must. The delayed presentation is inevitable. Early synovitis due to the organic biological foreign body may progress to septic arthritis, if untreated may result in knee stiffness or chronic osteomyelitis of patella. CASE REPORT: We report a case of thorn prick injury to the left patella in an 8-years-old boy who neglected the incident of thorn prick while playing with his peer group 10 days ago and presented with features of sub-acute septic arthritis...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28506571/tumor-necrosis-factor-receptor-associated-factor-traf-6-inhibition-mitigates-the-pro-inflammatory-roles-and-proliferation-of-rheumatoid-arthritis-fibroblast-like-synoviocytes
#11
Lang-Jing Zhu, Tie-Cheng Yang, Qiang Wu, Li-Ping Yuan, Zhen-Wei Chen, Min-Hong Luo, Hai-Ou Zeng, Dong-Ling He, Cai-Ju Mo
BACKGROUND: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) play a crucial role in RA through producing inflammatory cytokines and proteases which could cause cartilage destruction. We showed previously that elevated expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) in RA synovium correlated significantly with the severity of synovitis and the number of infiltrated inflammatory cells. The aims of this study are to detect the roles of TRAF6 in RA-FLSs...
May 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28500364/radiologists-need-to-be-aware-of-secondary-central-venous-stenosis-in-patients-with-sapho-syndrome
#12
Mizuho Suzuki, Hidenori Kanazawa, Takeshi Shinozaki, Hideharu Sugimoto
OBJECTIVES: We aimed to define central venous stenosis (CVS) caused by sternocostoclavicular hyperostosis as a feature of synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome on routine contrast-enhanced computed tomography (CT) images. The relationship between SAPHO syndrome and CVS without venous thrombosis caused by anterior chest wall compression has not been investigated. Therefore, the present study evaluated CVS in patients with SAPHO syndrome at our hospital. METHODS: We retrospectively reviewed contrast-enhanced CT images of ten patients with suspected or diagnosed SAPHO syndrome between January 2007 and November 2015...
May 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28497350/synovial-cellular-and-molecular-markers-in-rheumatoid-arthritis
#13
REVIEW
M Asif Amin, David A Fox, Jeffrey H Ruth
The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis...
May 11, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28488454/diagnostic-accuracy-of-single-compartment-magnetic-resonance-arthrography-in-detecting-common-causes-of-chronic-wrist-pain
#14
A M Asaad, A Andronic, M P Newby, J W K Harrison
We reviewed a series of 50 consecutive wrist arthroscopy patients who had been investigated pre-operatively by direct magnetic resonance arthrography and calculated the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of magnetic resonance arthrography in detecting full-thickness triangular fibrocartilage complex tears, intrinsic carpal ligamentous lesions, wrist synovitis and chondral lesions in the radiocarpal joint. The sensitivities of magnetic resonance arthrography in detecting central triangular fibrocartilage complex tears, peripheral triangular fibrocartilage complex tears, scapholunate ligament tears, lunotriquetral ligament tears, dorsal synovitis and radiocarpal chondral lesions were 89%, 63%, 71%, 100%, 32% and 65%, respectively, and its specificities in detecting these lesions were 91%, 98%, 89%, 94% 94% and 97%, respectively...
March 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28485176/the-role-of-il-17-in-the-treatment-of-psoriatic-arthritis
#15
Ennio Lubrano, Fabio Massimo Perrotta
Psoriatic arthritis (PsA) is a chronic inflammatory articular disease characterized by psoriasis, synovitis and enthesitis. Current treatment of PsA is mainly based on the use of classical and biological DMARDs; however, 30-40% of patients could not respond to these or have a loss of response. Areas covered: Recently, the discovery of new pathogenic mechanisms have made possible the development of new drugs that target the IL-17 with the possibility to interfere with the Th17 cells that are considered the cell type mainly involved in the development of the inflammation in PsA...
May 16, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28482926/structural-predictors-of-response-to-intra-articular-steroid-injection-in-symptomatic-knee-osteoarthritis
#16
Nasimah Maricar, Matthew J Parkes, Michael J Callaghan, Charles E Hutchinson, Andrew D Gait, Richard Hodgson, David T Felson, Terence W O'Neill
BACKGROUND: The aim was to examine if structural factors could affect response to intra-articular steroid injections (IASI) in knee osteoarthritis (OA). METHOD: Persons with painful knee OA participated in an open-label trial of IASI where radiographic joint space narrowing (JSN) and Kellgren-Lawrence (KL) grade, whole-organ magnetic resonance imaging (MRI) scores (WORMS) and quantitative assessment of synovial tissue volume (STV) were assessed on baseline images...
May 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28479059/comparison-of-pre-revision-magnetic-resonance-imaging-and-operative-findings-in-mechanically-assisted-crevice-corrosion-in-symptomatic-metal-on-polyethylene-total-hip-arthroplasties
#17
Pavel P Morozov, Munib Sana, Brian J McGrory, Steven W Farraher, Tod G Abrahams
BACKGROUND: Failed total hip arthroplasty (THA) caused by mechanically assisted crevice corrosion (MACC) has serious consequences-notably, adverse local tissue reactions. Metal artifact reduction sequence (MARS) magnetic resonance imaging (MRI) has been used to evaluate failed THA for other reasons but has not been assessed for the analysis of cases of MACC in the setting of metal-on-polyethylene arthroplasties. METHODS: We examined the correlation between preoperative MARS MRI and surgical findings in a cohort of 20 consecutive patients undergoing revision THA for symptomatic MACC without other associated orthopedic diagnoses...
March 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28477219/reliability-of-ultrasound-grading-traditional-score-and-new-global-omeract-eular-score-system-gloess-results-from-an-inter-and-intra-reading-exercise-by-rheumatologists
#18
Lucio Ventura-Ríos, Cristina Hernández-Díaz, Diana Ferrusquia-Toríz, Esteban Cruz-Arenas, Pedro Rodríguez-Henríquez, Ana Laura Alvarez Del Castillo, Alfredo Campaña-Parra, Efrén Canul, Gerardo Guerrero Yeo, Juan Jorge Mendoza-Ruiz, Mario Pérez Cristóbal, Sandra Sicsik, Karina Silva Luna
This study aims to test the reliability of ultrasound to graduate synovitis in static and video images, evaluating separately grayscale and power Doppler (PD), and combined. Thirteen trained rheumatologist ultrasonographers participated in two separate rounds reading 42 images, 15 static and 27 videos, of the 7-joint count [wrist, 2nd and 3rd metacarpophalangeal (MCP), 2nd and 3rd interphalangeal (IPP), 2nd and 5th metatarsophalangeal (MTP) joints]. The images were from six patients with rheumatoid arthritis, performed by one ultrasonographer...
May 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28472738/cartilage-lesions-in-feline-stifle-joints-associations-with-articular-mineralizations-and-implications-for-osteoarthritis
#19
Alexandra Leijon, Charles J Ley, Antonia Corin, Cecilia Ley
Feline stifle osteoarthritis (OA) is common, however little is known about the early stages of the disease. Furthermore, the importance of small articular mineralizations (AMs) in feline stifle OA is controversial. This study aimed to describe microscopic articular cartilage lesions and to investigate associations between cartilage lesions and AMs, synovitis, osteochondral junction findings and subchondral bone sclerosis. Stifles of 29 cats, aged 1-23years and euthanized for reasons other than stifle disease, were examined...
April 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28472071/associations-between-mri-features-versus-knee-pain-severity-and-progression-data-from-the-vancouver-longitudinal-study-of-early-knee-osteoarthritis
#20
Eric C Sayre, Ali Guermazi, John M Esdaile, Jacek A Kopec, Joel Singer, Anona Thorne, Savvas Nicolaou, Jolanda Cibere
OBJECTIVE: To determine associations between features of osteoarthritis (OA) on MRI and knee pain severity and knee pain progression. DESIGN: Baseline, 3.3- and 7.5-year assessments were performed for 122 subjects with baseline knee pain (age 40-79), sample-weighted for population (with knee pain) representativeness. MRIs were scored for: osteophytes (0:absent to 3:large); cartilage (0:normal to 4:full thickness defect; 0/1 collapsed); subchondral sclerosis (0:none to 3:>50% of site), subchondral cyst (0:absent to 3:severe), bone marrow lesions (0:none to 3:≥50% of site); and meniscus (0:normal to 3:maceration/resection), in 6-8 regions each...
2017: PloS One
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