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https://www.readbyqxmd.com/read/29457379/levels-of-cytokines-and-micrornas-in-individuals-with-asymptomatic-hyperuricemia-and-ultrasonographic-findings-of-gout-a-bench-to-bedside-approach
#1
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29455267/reactive-arthritis-update-2018
#2
A García-Kutzbach, J Chacón-Súchite, H García-Ferrer, I Iraheta
At this time, reactive arthritis (ReA) is considered to be part of the spectrum of the spondyloarthritis, previously known as Reiter's syndrome, and refers to an infection induced systemic illness, characterized by a sterile synovitis occurring in a genetically predisposed individual, secondary to an infection localized in a distant organ/system, but also accompanied with multiple extra articular manifestations.
February 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29455266/inflammatory-tenosynovitis-and-enthesitis-induced-by-immune-checkpoint-inhibitor-treatment
#3
Jun Inamo, Yuko Kaneko, Tsutomu Takeuchi
Reports about immune-related adverse events (IrAEs) induced by immune checkpoint inhibitors (ICIs) have been increasing. Although the importance of understanding joint involvement and myalgia as an IrAE has grown, little is known about its characteristics. The aim of this study was to investigate the incidence and clinical characteristics of articular IrAEs. We reviewed 133 patients who were treated with ICIs in our institution and referred to our rheumatologic. Among them, 2 (1.5%) developed arthritis during the use of anti-PD-1 inhibitor, and there was one patient with joint pain after anti-PD-L1 inhibitor who was referred to our department from another institution...
February 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29454670/ultrasonography-and-detection-of-subclinical-joints-and-tendons-involvements-in-systemic-lupus-erythematosus-sle-patients-a-cross-sectional-multicenter-study
#4
Carine Salliot, Amélie Denis, Emmanuelle Dernis, Vincent Andre, Aleth Perdriger, Jean-David Albert, Saloua Mammou Mraghni, Isabelle Griffoul-Espitalier, Mohamed Hamidou, Benoit Le Goff, Sandrine Jousse Joulin, Thierry Marhadour, Christophe Richez, Nicolas Poursac, Estebaliz Lazaro, Stéphanie Rist, Anca Corondan, Clara Quinten, Virginie Martaillé, Antoine Valéry, Emilie Ducourau
OBJECTIVES: The aims of this study in SLE population were 1) to describe ultrasonography (US) joint abnormalities, 2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, 3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities. METHOD: For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination...
February 15, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29443770/whether-innate-immune-together-with-genetic-factor-are-involved-in-leukemic-arthritis-a-case-report-and-review-of-the-literature
#5
Danyi Xu, Guanhua Xu, Jin Lin
We report a case of leukemic arthritis (LA) of monocytic differentiation, which presented with spondyloarthritis-like symptoms and a positive human leukocyte antigen-B27, and discuss its potential mechanisms.The patient was admitted because of pain in her right knee and lower back for 18 months. Magnetic resonance imaging showed diffuse hyperintense signal in the bilateral liac bones and bone marrow edema and synovitis in the right knee.The diagnosis of acute monocytic leukemia and LA were concluded by bone marrow aspiration and flow cytometry of the synovial fluid...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29439608/a-review-of-ustekinumab-in-the-treatment-of-psoriatic-arthritis
#6
Janet Roberts, Darren D O'Rielly, Proton Rahman
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. The IL-23/IL-17 axis is an important pathway in the development of psoriatic disease. Ustekinumab is a fully human monoclonal IgG1 antibody that binds to the p40 subunit of IL-12 and IL-23, which, in turn, inhibits downstream signaling pathways. PSUMMIT-1 and PSUMMIT-2 are two pivotal Phase III trials demonstrating global improvement in primary and secondary outcomes including inhibition of radiographic progression. Therapeutic benefit of ustekinumab for synovitis appears independent of previous disease modifying antirheumatic disease or anti-TNF exposure...
February 14, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29438603/from-early-radiographic-knee-osteoarthritis-to-joint-arthroplasty-determinants-of-structural-progression-and-symptoms
#7
Frank W Roemer, C Kent Kwoh, Tomoko Fujii, Michael J Hannon, Robert M Boudreau, David J Hunter, Felix Eckstein, Markus R John, Ali Guermazi
OBJECTIVE: Aims were to assess (1) structural progression in knees with no/mild radiographic osteoarthritis (ROA) (i.e. Kellgren-Lawrence (K-L) grades 0 to 2) that will undergo knee replacement (KR) during a 5-year period; (2) differences in structural damage on MRI between knees with no/mild ROA vs. those with severe ROA (i.e. K-L 3 and 4) at baseline; and (3) differences in pain levels between those groups. METHODS: All participants who underwent KR from baseline (BL) to 60 months were drawn from the Osteoarthritis Initiative...
February 13, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29438127/osteoarthritis-pain-recent-advances-and-controversies
#8
Hans-Georg Schaible
PURPOSE OF REVIEW: Osteoarthritis is one of the most frequent causes of chronic pain. Because there is no causal treatment of osteoarthritis, sufficient pain control is of uppermost importance but often not met. The review reports recent advances and controversies in our understanding of osteoarthritis pain and its treatment. RECENT FINDINGS: Osteoarthritis pain is determined by processes at different levels. An important local factor of pain generation in the joint is inflammation such as synovitis, and neuropathic components of osteoarthritis pain are being discussed...
February 12, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29437586/baseline-ultrasound-examination-as-possible-predictor-of-relapse-in-patients-affected-by-juvenile-idiopathic-arthritis-jia
#9
Orazio De Lucia, Viviana Ravagnani, Francesca Pregnolato, Arvena Hila, Irene Pontikaki, Maurizio Gattinara, Micol Romano, Valeria Gerloni, Sara Pieropan, Antonella Murgo, Maurizio Rossini, Rolando Cimaz, Pier Luigi Meroni
OBJECTIVES: To define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) and to assess whether synovitis detected by ultrasonography in clinically inactive patients predicts arthritis flares. METHODS: 88 consecutive patients with JIA-46 (52%) with persistent oligoarthritis, 15 (17%) with extended oligoarthritis, 15 (17%) with rheumatoid factor-negative polyarthritis and 12 (14%) with other forms of JIA, all clinically inactive for a minimum of 3 months-underwent ultrasound (US) assessment of 44 joints...
February 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29434479/osteoarthritis-and-the-complement-cascade
#10
REVIEW
Sandeep Silawal, Jakob Triebel, Thomas Bertsch, Gundula Schulze-Tanzil
Accumulating evidence demonstrates that complement activation is involved in the pathogenesis of osteoarthritis (OA). However, the intimate complement regulation and cross talk with other signaling pathways in joint-associated tissues remain incompletely understood. Recent insights are summarized and discussed here, to put together a more comprehensive picture of complement involvement in OA pathogenesis. Complement is regulated by several catabolic and inflammatory mediators playing a key role in OA. It seems to be involved in many processes observed during OA development and progression, such as extracellular cartilage matrix (ECM) degradation, chondrocyte and synoviocyte inflammatory responses, cell lysis, synovitis, disbalanced bone remodeling, osteophyte formation, and stem cell recruitment, as well as cartilage angiogenesis...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29434332/the-p55tnfr-ikk2-ripk3-axis-orchestrates-arthritis-by-regulating-death-and-inflammatory-pathways-in-synovial-fibroblasts
#11
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
NFκB activation and regulated cell death are important in tissue homeostasis, inflammation and pathogenesis. Here we show the role of the p55TNFR-IKK2l-Ripk3 axis in the regulation of synovial fibroblast homeostasis and pathogenesis in TNF-mediated mouse models of arthritis. Mesenchymal-specific p55TNFR triggering is indispensable for arthritis in acute and chronic TNF-dependent models. IKK2 in joint mesenchymal cells is necessary for the development of cartilage destruction and bone erosion; however, in its absence synovitis still develops...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29431119/hypermetabolic-macrophages-in-rheumatoid-arthritis-and-coronary-artery-disease-due-to-glycogen-synthase-kinase-3b-inactivation
#12
Markus Zeisbrich, Rolando E Yanes, Hui Zhang, Ryu Watanabe, Yinyin Li, Lukas Brosig, Jison Hong, Barbara B Wallis, John C Giacomini, Themistocles L Assimes, Jörg J Goronzy, Cornelia M Weyand
OBJECTIVES: Accelerated atherosclerotic disease typically complicates rheumatoid arthritis (RA), leading to premature cardiovascular death. Inflammatory macrophages are key effector cells in both rheumatoid synovitis and the plaques of coronary artery disease (CAD). Whether both diseases share macrophage-dependent pathogenic mechanisms is unknown. METHODS: Patients with RA or CAD (at least one myocardial infarction) and healthy age-matched controls were recruited into the study...
February 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29430239/a-case-of-paraneoplastic-remitting-seronegative-symmetrical-synovitis-with-pitting-edema-syndrome-improved-by-chemotherapy
#13
Takahiko Sakamoto, Shuji Ota, Terunobu Haruyama, Masashi Ishihara, Maika Natsume, Yoko Fukasawa, Shigeru Tanzawa, Ryo Usui, Takeshi Honda, Yasuko Ichikawa, Kiyotaka Watanabe, Nobuhiko Seki
The patient was a 69-year-old male who had started experiencing acute-onset pain in both shoulder joints and edema of both hands and feet. His symptoms progressively worsened within 1 month. Laboratory data indicated elevated CRP and erythrocyte sedimentation rate despite the normal range of antinuclear antibodies and rheumatoid factor and normal organ function. Furthermore, imaging data of the hand indicated synovitis without bone erosions. Meanwhile, chest CT revealed a lung tumor, leading to a diagnosis of primary lung adenocarcinoma with EGFR mutation (cT2aN3M0, stage IIIB)...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29430127/pigmented-villonodular-synovitis-a-close-mimic-of-metastasis-on-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#14
Kunal Shaha, Archi Agrawal, Neha Mittal, Nilendu Purandare, Umesh Mahantshetty, Sneha Shah, Amey Puranik, Venkatesh Rangarajan
No abstract text is available yet for this article.
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29423066/interferon-%C3%AE-protects-against-avascular-osteonecrosis-through-interleukin-6-inhibition-and-silent-information-regulator-transcript-1-upregulation
#15
Kyoung Min Kim, Sajeev Wagle, Young Jae Moon, Sung Il Wang, Byung-Hyun Park, Kyu Yun Jang, Jung Ryul Kim
Synovitis of the affected joint is a common in avascular osteonecrosis (AVN). Increased levels of pro-inflammatory cytokine interleukin-6 (IL-6) have been reported in AVN, but the mechanism of this increase remains unclear. Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, inhibits the release of inflammatory cytokines. Interferon β (IFN-β) has clear anti-inflammatory properties. We sought to investigate the effects of IFN-β treatment on AVN and to evaluate the specific signal pathway relating to IL-6 and SIRT1 affected during AVN...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415892/inhibition-of-wnt-%C3%AE-catenin-signaling-ameliorates-osteoarthritis-in-a-murine-model-of-experimental-osteoarthritis
#16
Caressa Lietman, Brian Wu, Sarah Lechner, Andrew Shinar, Madhur Sehgal, Evgeny Rossomacha, Poulami Datta, Anirudh Sharma, Rajiv Gandhi, Mohit Kapoor, Pampee P Young
Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and articular chondrocytes as well as the therapeutic effects of Wnt inhibition on OA disease severity. Mice underwent destabilization of the medial meniscus surgery and were treated by intra-articular injection with XAV-939, a small-molecule inhibitor of Wnt/β-catenin signaling...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29409140/a-multi-centre-retrospective-analysis-evaluating-performance-of-synovial-biopsy-techniques-arthroscopic-vs-ultrasound-guided-vs-blind-needle-biopsy
#17
Frances Humby, Vasco Romão, Antonio Manzo, Andrew Filer, Serena Bugatti, Elsa Vieira-Sousa, Stephen Kelly, Mihir Wechalekar, Manzoor Ahmed, Vidalba Rocher, Rebecca Hands, Carlomaurizio Montecucco, Joao Fonseca, Costantino Pitzalis
OBJECTIVES: This study aimed to evaluate whether choice of synovial biopsy technique (arthroscopic, blind needle (BN), ultrasound (US)-portal and forceps (P&F) and US-needle biopsy (NB) translates to significant variation in synovial tissue quality and quantity with the aim of informing recommendations for choice of synovial sampling technique within clinical trials. METHODS: 159 procedures were evaluated from 5 academic rheumatology centres. H&E stained paraffin embedded synovial sections were assessed in order to determine the proportion of graded synovial fragments, total area of tissue and synovitis score per procedure...
February 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29400369/correlation-between-protein-ykl-40-and-ultrasonographic-findings-in-active-knee-osteoarthritis
#18
Rositsa Karalilova, Maria Kazakova, Anastas Batalov, Victoria Sarafian
The aim of our study was to analyze the level of the glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and to search possible correlations with local inflammation and ultrasound (US) findings. MATERIAL AND METHODS: A prospective study with fifty consecutive patients with active knee OA (diagnosed based on the American College of Rheumatology criteria for OA with radiographic confirmation) was performed. Concentrations of YKL-40 in serum and synovial fluid were measured by ELISA...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29398959/synovectomy-using-samarium-153-hydroxyapatite-in-the-elbows-and-ankles-of-patients-with-hemophilic-arthropathy
#19
José Ulisses Manzzini Calegaro, Davi de Podestá Haje, Julian Machado, Mariana Sayago, Danielle C de Landa
This study aimed to evaluate synovectomy with samarium-153 hydroxyapatite (153Sm-HA) in synovitis of the elbows and ankles of hemophilic patients. The synovectomy was performed using 185 MBq of 153Sm-HA in 166 joints of 82 hemophilic patients, with a mean age of 24.4 years and follow-up of 12 and 42 months, comprising 63 ankles and 84 elbows. Arthropathy was characterized by recurrent joint bleeding. Episodes of hemarthrosis, use of clotting factors, and pain intensity were evaluated before and after treatment...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29395449/do-signs-of-an-effusion-of-the-temporomandibular-joint-on-magnetic-resonance-imaging-correlate-with-signs-and-symptoms-of-temporomandibular-joint-disease
#20
N Thomas, D E Harper, S Aronovich
Effusions are common among patients with disorders of the temporomandibular joint (TMJ), but publications are limited and results inconsistent about the correlation between them and important clinical variables, in particular severity of pain and degenerative disease. We organised a retrospective study of patients who presented for the evaluation and management of arthralgia of the TMJ and myofascial pain at the University of Michigan between 2011 and 2014. Inclusion criteria were: patients who had pain that was primarily arthrogenous, and coexisting myogenous pain, who had had initial non-surgical treatment, and arthroscopy of the TMJ with or without intramuscular injection of onabotulinumtoxinA (Botox,® Allegan, Weston, Fl, USA)...
February 2018: British Journal of Oral & Maxillofacial Surgery
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