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https://www.readbyqxmd.com/read/28440350/high-frequency-ultrasonography-of-the-hand-versus-anti-ra33-evaluation-in-early-rheumatoid-arthritis-a-pilot-study
#1
Andreea Lili Barbulescu, Paulina Lucia Ciurea, Carmen Mitran, Beatrice Andreea Chisalau, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Maria Balasoiu, Mihail Virgil Boldeanu, Horatiu Popoviciu, Florentin Ananu Vreju
AIM: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship with ultrasonographic (US) findings in patients with early RA. MATERIAL AND METHODS: We performed a prospective study which included 29 patients, diagnosed with early RA according to the ACR/EULAR 2010 criteria and 21 sex and age-matched control subjects...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28438383/remitting-seronegative-symmetrical-synovitis-with-pitting-edema-rs3pe-syndrome-induced-by-nivolumab
#2
Marie-Léa Gauci, Barouyr Baroudjian, Pauline Laly, Isabelle Madelaine, Laetitia Da Meda, Laetitia Vercellino, Martine Bagot, Frédéric Lioté, Cécile Pages, Céleste Lebbé
INTRODUCTION: A new articular syndrome described as immunrelated side effect of immunotherapy: PD-1 inhibitors have revolutionized the treatment of advanced melanoma but are responsible for immune-related toxicity. We report a case of remitting seronegative symetrical synovitis with pitting edema (RS3PE) syndrome induced by nivolumab. CASE REPORT: A 80 year-old man with stage IV BRAF-wild type and NRAS exon 2-mutated melanoma was treated first line by nivolumab 3mg/kg every 2 weeks...
March 8, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28436371/pigmented-villonodular-synovitis-various-manifestations-inconsistent-terminology-and-treatment-cases-study
#3
Paweł Kokoszka, Waldemar Woźniak, Łukasz Łapaj, Jacek Kruczyński
Pigmented villonodular synovitis (PVNS) as well as tenosynovial giant cell tumor (TGCT) are both diagnosed and described in two forms, namely a localized and diffuse type. They form a diverse group of proliferative lesions in articular synovium and tendon sheaths. The inconsistent terminology impedes communication between patients, orthopedic surgeons, radiologists and pathologists, leading to misunderstandings and delaying treatment. In this paper, we present three cases of PVNS/TGCT (involving the fourth toe extensor tendon sheath, hip joint after resurfacing and flexor hallucis longus tendon sheath) together with suggestions regarding the unification of the terminology as well as diagnosis and treatment...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28435577/intra-articular-localized-haemangioma-of-the-knee-mimicking-localized-pigmented-villonodular-synovitis-a-case-report
#4
G K Goki-Kamei, N M Norimasa-Matsubara, T T Teruyasu-Tanaka, K N Koji-Natsu, T S Toshihiro-Sugioka
Intra-articular synovial haemangioma of the knee is a benign tumour. However, diagnostic delay leads to degenerative changes in the cartilage and osteoarthritis due to recurrent haemarthrosis. Therefore, treatment should be performed immediately. We report the case of a localized synovial haemangioma arising from the medial plica in a 38-year old female presenting with pain and restricted range of motion in the right knee joint. Initially, we diagnosed this case as a localized pigmented villonodular synovitis (LPVS) based on MRI and arthroscopic findings and performed only arthroscopic en bloc excision of the mass and synovectomy around the mass for diagnostic confirmation...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28431182/joint-positions-matter-for-ultrasound-examination-of-ra-patients-increased-power-doppler-signal-in-neutral-versus-flat-position-of-hands
#5
Rusmir Husic, Angelika Lackner, Martin H Stradner, Josef Hermann, Christian Dejaco
Objective.: Position of joints might influence the result of US examination in patients with RA. The purpose of this work was to compare grey-scale (GS) and power Doppler (PWD) findings obtained in neutral vs flat position of hands. Methods.: A cross-sectional study of 42 RA patients with active disease. Two dimensional and 3D sonography of wrists and MCP joints were conducted in two different joint positions: neutral position, which is a slight flexion of the fingers with relaxed extensor muscles; and flat position, where all palm and volar sides of fingers touch the Table...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28429865/differential-effects-of-bleeds-on-the-development-of-arthropathy-basic-and-applied-issues
#6
REVIEW
L F D van Vulpen, S C Mastbergen, F P J G Lafeber, R E G Schutgens
Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as degenerative processes injuring synovium, cartilage and bone. These processes affect each other and may occur in parallel and/or sequentially. Clinically, the effects of joint bleeds are heterogeneous. A marked variability in joint damage is observed in patients with a similar bleeding history. Also late stage effects differ with some patients developing chronic synovitis, and others suffering from osteochondral degeneration called haemophilic arthropathy...
April 21, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28428648/ultrasound-of-ankles-in-the-diagnosis-of-complications-of-chikungunya-fever
#7
Roberto Mogami, João Luiz Pereira Vaz, Yêdda de Fátima Barcelos Chagas, Rodrigo Sperling Torezani, André de Almeida Vieira, Ana Célia Baptista Koifman, Yasmin Baptista Barbosa, Mirhelen Mendes de Abreu
OBJECTIVE: To describe the main ultrasound findings of chikungunya fever in the ankle. MATERIALS AND METHODS: This was a cross-sectional observational study involving 52 patients referred to the Hospital Universitário Pedro Ernesto and presenting with clinical and biochemical evidence of chikungunya fever. The examinations were performed by a radiologist with more than 20 years of experience in ultrasound. RESULTS: The predominant gender was female (in 88...
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28428036/giantcell-tumor-of-tendon-sheath-open-surgery-or-arthroscopic-synovectomy-a-systematic-review-of-the-literature
#8
REVIEW
Thibaut Noailles, Kevin Brulefert, Sylvain Briand, Pierre Marie Longis, Kevin Andrieu, Antoine Chalopin, François Gouin
PURPOSE: Giantcell tumor of tendon sheath(GCTTS)formelyknowned as pigmented villonodular synovitis (PVNS) is a benign, locally aggressive, proliferative disorder of the synovium involving a joint, bursa, or tendon sheath. Treatment ofGCTTSinvolves early surgical resection to limit articular destruction and the risk of recurrence. Synovectomy remains the treatment of choice forGCTTSbut without clear consensus to make an open or arthroscopic synovectomy andno certainty on the responsibility of surgery in the evolution towards the degenerative osteoarthritis...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28425031/the-cytokine-expression-in-synovial-membrane-and-the-relationship-with-pain-and-pathological-findings-at-hip-arthroscopy
#9
Kensuke Fukushima, Gen Inoue, Hisako Fujimaki, Kentaro Uchida, Masayuki Miyagi, Naoshige Nagura, Katsufumi Uchiyama, Naonobu Takahira, Masashi Takaso
BACKGROUND: Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS: We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we classified the chondral injury and synovitis, noted the incidence of labral tear and its instability, and a sample of the synovial membrane was harvested for quantitative PCR to determine levels of TNFα, IL1β, IL6, ADAMTS4, MMP1, and MMP3...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28423434/-radiologic-presentation-in-subspine-impingement-and-correlation-with-intraarticular-impingement-in-the-hip
#10
David R Krüger, Michael Schütz, Carsten Perka, Jörg Schröder
Background Besides the known intraarticular femoroacetabular impingement (FAI), recently forms of extra-articular impingement of the hip have been increasingly recognized. Recent studies have described an extra-articular impingement between a distal extension of the anterior inferior iliac spine (AIIS) and the femoral neck (AIIS or subspine impingement). Evidently, an association between this subspine impingement and an intraarticular FAI seems to exist. Little is known about the incidence of this impingement type and the value of its radiological diagnostics...
April 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28423042/transforming-growth-factor-%C3%AE-1-enhances-heme-oxygenase-1-expression-in-human-synovial-fibroblasts-by-inhibiting-microrna-519b-synthesis
#11
Shu-Jui Kuo, Wei-Hung Yang, Shan-Chi Liu, Chun-Hao Tsai, Horng-Chaung Hsu, Chih-Hsin Tang
BACKGROUND: Osteoarthritis (OA) is manifested by synovial inflammation and cartilage destruction that is directly linked to synovitis, joint swelling and pain. In the light of the role of synovium in the pathogenesis and the symptoms of OA, synovium-targeted therapy is a promising strategy to mitigate the symptoms and progression of OA. Transforming growth factor beta 1 (TGF-β1), a secreted homodimeric protein, possesses unique and potent anti-inflammatory and immune-regulatory properties in many cell types...
2017: PloS One
https://www.readbyqxmd.com/read/28419134/development-of-mismatch-amplification-mutation-assays-for-the-differentiation-of-ms1-vaccine-strain-from-wild-type-mycoplasma-synoviae-and-ms-h-vaccine-strains
#12
Zsuzsa Kreizinger, Kinga Mária Sulyok, Dénes Grózner, Katinka Bekő, Ádám Dán, Zoltán Szabó, Miklós Gyuranecz
Mycoplasma synoviae is an economically significant pathogen in the poultry industry, inducing respiratory disease and infectious synovitis in chickens and turkeys, and eggshell apex abnormality in chickens. Eradication, medication and vaccination are the options for controlling M. synoviae infection. Currently there are two commercial, live, attenuated vaccines available against M. synoviae: the temperature sensitive MS-H vaccine strain and the NAD independent MS1 vaccine strain. Differentiation of vaccine strains from field isolates is essential during vaccination and eradication programs...
2017: PloS One
https://www.readbyqxmd.com/read/28416969/repeatability-and-agreement-of-ultrasonography-with-computed-tomography-for-evaluating-forefoot-structure-in-the-coronal-plane
#13
Keisuke Matsubara, Tomofumi Matsushita, Yuto Tashiro, Seishiro Tasaka, Takuya Sonoda, Yasuaki Nakayama, Yuki Yokota, Yusuke Suzuki, Mirei Kawagoe, Tomoki Aoyama
BACKGROUND: Forefoot structure is important to understand some foot problems such as hallux valgus and metatarsalgia. Ultrasonography (US) is a highly portable, noninvasive, low cost, and fast imaging method, especially when compared to magnetic resonance imaging (MRI), computed tomography (CT), and radiography. As the use of US for evaluating forefoot bony structure has not been validated, except for the presence of synovitis, erosions and bursitis within the forefoot in people with inflammatory arthritis, the purpose of this study was to determine whether US is a reliable method for evaluating forefoot structure...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28412700/takayasu-arteritis-and-spondyloarthritis-coincidence-or-association-a-study-of-14-cases
#14
Elodie Rivière, Laurent Arnaud, Mikael Ebbo, Yannick Allanore, Pascal Claudepierre, Emmanuelle Dernis, Jean-Marc Ziza, Corinne Miceli-Richard, Peggy Philippe, Christophe Richez, Martin Soubrier, Rakiba Belkhir, Raphaèle Seror, Xavier Mariette, Stephan Pavy
OBJECTIVE: Spondyloarthritis (SpA) and Takayasu arteritis (TA) are 2 chronic inflammatory diseases; their coexistence in a single patient is uncommon. The aims of our study were to describe clinical features of patients having SpA associated with TA and to identify some characteristics of the types of patients with SpA associated with TA. We also analyzed treatments used in this context. METHODS: This French multicenter retrospective survey called for observations on behalf of the Club Rhumatismes et Inflammations, with a standardized questionnaire established by the investigators...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28407127/no-clear-association-between-ultrasound-remission-and-health-status-in-rheumatoid-arthritis-patients-in-clinical-remission
#15
Myrthe van der Ven, T Martijn Kuijper, Andreas H Gerards, Ilja Tchetverikov, Angelique E Weel, Jendé van Zeben, Johanna M Hazes, Jolanda J Luime
Objectives.: Although RA patients achieve clinical remission, risk of flare still exists. Given the association between US synovitis and increased risk of flare, it is of clinical interest whether these patients report a different health status. Therefore, our aim was to evaluate the frequency of US remission in RA patients in clinical remission and to compare the health status of RA patients in clinical remission with those who were also in US remission. Methods: ...
April 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28406954/therapeutic-efficacy-of-intra-articular-hyaluronan-derivative-and-platelet-rich-plasma-in-mice-following-axial-tibial-loading
#16
Xin Duan, Linda J Sandell, Nobuaki Chinzei, Nilsson Holguin, Matthew J Silva, Antonella Schiavinato, Muhammad Farooq Rai
OBJECTIVE: To investigate the therapeutic potential of intra-articular hyaluronan-derivative HYADD® 4-G and/or platelet-rich plasma (PRP) in a mouse model of non-invasive joint injury. METHODS: Non-invasive axial tibial loading was used to induce joint injury in 10-week-old C57BL/6J mice (n = 86). Mice underwent a single loading of either 6 Newton (N) or 9N axial tibial compression. HYADD® 4-G was injected intra-articularly at 8 mg/mL or 15 mg/mL either before or after loading with or without PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28399875/asas-definition-for-sacroiliitis-on-mri-in-spa-applicable-to-children
#17
Nele Herregods, Joke Dehoorne, Filip Van den Bosch, Jacob Lester Jaremko, Joke Van Vlaenderen, Rik Joos, Xenofon Baraliakos, Gaëlle Varkas, Koenraad Verstraete, Dirk Elewaut, Lennart Jans
BACKGROUND: The Assessment of Spondyloarthritis International Society (ASAS) definition for a 'positive' Magnetic Resonance Imaging (MRI) for sacroiliitis is well studied and validated in adults, but studies about the value of this definition in children are lacking. The aim of this study is to evaluate whether the adult ASAS definition of a positive MRI of the sacroiliac joints can be applied to children with a clinical suspicion of Juvenile Spondyloarthritis (JSpA). METHODS: Two pediatric musculoskeletal radiologists blinded to clinical data independently retrospectively reviewed sacroiliac (SI) joint MRI in 109 children suspected of sacroiliitis...
April 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28398508/examining-the-validity-of-the-rheumatoid-arthritis-magnetic-resonance-imaging-score-according-to-the-omeract-filter-a-systematic-literature-review
#18
Thasia G Woodworth, Olga Morgacheva, Olga L Pimienta, Orrin M Troum, Veena K Ranganath, Daniel E Furst
Objective.: To examine whether the RA MRI score (RAMRIS) for RA of the wrist/hand meets the OMERACT filter criteria-truth (validity), discrimination and feasibility. Methods.: We conducted a systematic literature review in PubMed and Scopus, from 1970 through June 2014, focused on MRI measures of synovitis, osteitis/bone marrow oedema, erosions and/or joint space narrowing in RA randomized controlled trials and observational studies with cohort size ⩾10. Strength of evidence was assessed using the Cochrane Handbook criteria...
April 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/28389877/results-and-recurrence-of-pigmented-villonodular-synovitis-of-the-ankle-does-diffuse-pvns-with-extra-articular-extension-tend-to-recur-more-often
#19
QinWei Guo, WeiLi Shi, Chen Jiao, Xing Xie, Dong Jiang, YueLin Hu
PURPOSE: The aim of this study was to provide the outcomes and to analyze the recurrence of Pigmented Villonodular Synovitis (PVNS) of the ankle joint treated by surgical synovectomy. METHODS: Thirty-one PVNS cases of the ankle, including 5 localized PVNS cases and 26 diffuse PVNS cases, were treated in our institute between 2004 and 2015. The median age was 35 (range 18-63) years. The 5 localized PVNS cases were treated with partial synovectomy (group I); 10 diffuse PVNS cases limited to intra-articular synovium received arthroscopic comprehensive synovectomy (group II); and 16 cases with diffuse PVNS spreading to extra-articular tendon sheaths underwent combined arthroscopic and open synovectomy (group III)...
April 7, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28389347/patho-bacteriological-investigation-of-an-outbreak-of-mycoplasma-bovis-infection-in-calves-emerging-stealth-assault
#20
Fazal Mahmood, Ahrar Khan, Riaz Hussain, Imtiaz Ahmad Khan, Rao Zahid Abbas, Hafiz Muhammad Ali, Muhammad Younus
Mycoplasma bovis (M. bovis) is an important bacterium, causing severe respiratory infection, and arthritis in dairy animals worldwide. This study is based on 50 suckling calves among which 15 showed respiratory distress, lameness and swollen joints and died later. M. bovis was isolated and identified from all dead (n = 15) and live (17.14%; 06 out of 35) calves on the basis of bacteriological examination. In morbid calves, the carpus and stifle joints were severely affected, while necropsy revealed multiple well-circumscribed calcified abscesses and caseous exudates in cranio-ventral and diaphragmatic lobes of lungs...
April 4, 2017: Microbial Pathogenesis
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