Meinolf Suttorp, Stephanie Sembill, Krzysztof Kalwak, Markus Metzler, Frederic Millot
Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months ( n = 1), over 6 weeks ( n = 1), over 1-2 weeks ( n = 2), over several days ( n = 2), or 24 h ( n = 1), while the remaining 4 boys reported continuous erection lasting over 11-12 h...
July 19, 2023: Journal of Clinical Medicine