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endobronchial ultrasound

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https://www.readbyqxmd.com/read/29139101/-endobronchial-ultrasound-ebus-an-update-2017
#1
K Darwiche, F Özkan, C Wolters, S Eisenmann
Endobronchial Ultrasound (EBUS) with the two modalities curved and radial EBUS significantly improved the diagnostics in several pulmonary diseases. The examination and staging of mediastinal and hilar lymph nodes in patients with known or suspected lung malignancy as well as the evaluation of unknown pulmonary or mediastinal lesions can be achieved with minimal invasive means when using EBUS. More invasive surgical procedures for diagnostic purposes can be omitted. The diagnostic yield also increases when EBUS is applied in sarcoidosis or mediastinal lymph node tuberculosis but only to some extend in case of lymphoma...
November 2017: Pneumologie
https://www.readbyqxmd.com/read/29131539/molecular-testing-on-endobronchial-ultrasound-ebus-fine-needle-aspirates-fna-impact-of-triage
#2
Simon Sung, John P Crapanzano, David DiBardino, David Swinarski, William A Bulman, Anjali Saqi
BACKGROUND: Endobronchial ultrasound (EBUS)-guided fine needle aspiration (FNA) is performed to diagnose and stage lung cancer. Multiple studies have described the value of Rapid On-Site Evaluation (ROSE), but often the emphasis is upon diagnosis than adequacy for molecular testing (MT). The aim was to identify variable(s), especially cytology-related, that can improve MT. METHODS: A search for EBUS-FNAs with ROSE was conducted for lung adenocarcinomas or when this diagnosis could not be excluded...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124891/the-diagnostic-value-of-tissue-button-technique-for-specimen-accusation-during-endobronchial-ultrasound-guided-transbronchial-fine-needle-aspiration
#3
Oren Fruchter, Anna Breslavsky, Tatyana Brozgol, Anna Grossman, Kessi Mikhailova, Alexey Bugayov, Kassa Shimelis, Hananya Vaknine, Oleg Sukmanov
INTRODUCTION: The quality of tissue acquisition during Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB ) technique the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value. OBJECTIVES: To retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS-TBNA for various malignant and benign conditions...
November 10, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#4
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29114418/stop-being-so-sensitive-an-exceptionally-rare-report-of-ustekinumab-induced-sub-acute-hypersensitivity-pneumonitis
#5
Azka Ali, Jason Chertoff, Christopher Harden, Dara Wakefield, James Wynne
Hypersensitivity pneumonitis (HSP) is a rare syndrome characterised by granulomatous inflammatory lung disease due to repeated sensitisation from a specific antigen. We present the case of a 61-year old male veteran with a history of nodular eczema who presented with 2 weeks of progressive dyspnoea on exertion and pleuritic chest pain. The patient was started on ustekinumab 5 weeks prior to presentation. Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29105350/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-with-the-flexible-19-gauge-needle
#6
Rocco Trisolini, Filippo Natali, Marco Ferrari, Vanina Livi, Daniela Paioli, Micaela Romagnoli, Alessandra Cancellieri
INTRODUCTION AND OBJECTIVES: Endosonography has become standard of care in the diagnostic work-up of mediastinal lymphadenopathy and peribronchial lung lesions, but its success rate in some specific settings/conditions may be hampered by limited needle flexibility and size. We report on our initial experience with the 19G Flex needle, characterized by larger size and greater flexibility as compared with the currently available cytology needles. METHODS: Retrospective review of prospectively collected data on the first 13 consecutive patients submitted to endosonography with the 19G Flex needle...
November 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29099004/isolated-pulmonary-involvement-in-erdheim-chester-disease
#7
Enambir Singh Josan, Jason W Green, Syed Imran M Zaidi, Jayantilal B Mehta
Erdheim-Chester disease is a rare non-Langerhans cell histiocytic disorder. It is primarily a disease of the long bones. Pulmonary involvement in systemic disease is detected in about half the reported cases. Isolated lung involvement is extremely rare with no clear recommendations for treatment. A 52-year-old caucasian male was evaluated for 1.9 cm × 1.6 cm spiculated nodule in the right upper lobe. Pulmonary function testing and bronchoscopy with endobronchial ultrasound, transbronchial biopsy, and microbiology were inconclusive...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29098999/tracheobronchial-puncture-site-nodular-reaction-tpnr-following-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-systematic-review-of-case-reports
#8
REVIEW
Karan Madan, Pavan Tiwari, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and efficacious diagnostic modality for lung cancer staging and evaluation of undiagnosed mediastinal lymphadenopathy. Procedure-related complications are uncommon. We herein report an infrequently described phenomenon following EBUS-TBNA in which two patients developed nodular granulation tissue at the tracheobronchial puncture site. On systematic review, we found description of such phenomena by terminologies such as endobronchial inflammatory polyp, granuloma, and endobronchial mass...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29097432/endoscopic-ultrasound-fine-needle-aspiration-by-experienced-pulmonologists-a-cusum-analysis
#9
Paul Leong, Sheetal Deshpande, Louis B Irving, Philip G Bardin, Michael W Farmer, Barton R Jennings, Daniel P Steinfort
Endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) is an established, minimally invasive way to sample intrathoracic abnormalities. The EBUS scope can be passed into the oesophagus to perform endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA). In cases of suspected lung cancer, a combination of the two techniques is now recommended by consensus guidelines. EBUS TBNA is usually performed by pulmonologists; however, the learning curve for EUS-B-FNA, which may be performed during the same procedure, has not been described...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29082634/learning-curve-and-advantages-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-as-a-first-line-diagnostic-and-staging-procedure
#10
Ching-Kai Lin, Chao-Lun Lai, Lih-Yu Chang, Yueh-Feng Wen, Chao-Chi Ho
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is now the standard for mediastinal lymph node staging of lung cancer. Training and maintenance of technical skills is very important in order to apply new techniques in clinical use. METHODS: A retrospective chart review was performed of patients who underwent EBUS-TBNA from November 2009 to December 2015. We assessed the learning curve, accuracy (%), and whether this procedure shortened the duration of lung cancer staging...
October 30, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29076937/endobronchial-ultrasound-transbronchial-needle-aspiration-for-the-diagnosis-of-lymphoma
#11
Sheetal Gandotra, Travis Dotson, Zanetta Lamar, Christina Bellinger
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) presents a minimally invasive way to evaluate abnormal mediastinal and hilar adenopathy. Although EBUS has been established as an effective modality to diagnose lung cancer, its sensitivity for the diagnosis of lymphoma has been demonstrated to be lower. Because of these lower yields uncertainty persists about the ability of EBUS-TBNA to reliably diagnose lymphoma and questions remain regarding the utility of EBUS-TBNA as a first-line biopsy modality for patients suspected of having lymphoma...
October 25, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29071277/ebus-tbna-in-pet-positive-lymphadenopathies-in-treated-cancer-patients
#12
Juliana Guarize, Monica Casiraghi, Stefano Donghi, Chiara Casadio, Cristina Diotti, Niccolò Filippi, Clementina Di Tonno, Valeria Midolo, Patrick Maisonneuve, Daniela Brambilla, Chiara Maria Grana, Francesco Petrella, Lorenzo Spaggiari
Mediastinal lymph node enlargement is common in the follow-up of patients with previously treated malignancies. The aim of this study is to assess the role of endobronchial ultrasound (EBUS) transbronchial needle aspiration (TBNA) for cyto-histological evaluation of positron emission tomography with (18)fluorodeoxyglucose (PET) positive mediastinal and hilar lymph nodes developed in patients with previous malignancies. All EBUS-TBNA cases performed from January 2012 to May 2016 were retrospective reviewed. Results of EBUS-TBNA in patients with mediastinal and/or hilar lymphadenopathies were analysed...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29054229/complications-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#13
Hidenao Kayawake, Toyofumi F Chen-Yoshikawa, Hiromi Oda, Hideki Motoyama, Masatsugu Hamaji, Toshi Menju, Akihiro Aoyama, Toshihiko Sato, Makoto Sonobe, Hiroshi Date
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is considered useful for the staging and diagnosis of lung cancer or thoracic lymph node enlargement; however, little is known about its complications. Between July 2009 and November 2016, 413 patients underwent EBUS-TBNA, and four complications (0.97%) occurred. Here we report four cases involving complications of EBUS-TBNA, including mediastinitis (n = 2), obstructive pneumonia (n = 1), and airway obstruction requiring admission to the intensive care unit (n = 1)...
November 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29053224/programmed-death-ligand-1-testing-of-lung-cancer-cytology-specimens-obtained-with-bronchoscopy
#14
Sean P Stoy, Lauren Rosen, Jeffrey Mueller, Septimiu Murgu
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression testing is recommended by guidelines for patients with advanced non-small cell lung cancer (NSCLC). The primary objective of the current study was to determine the success rate of PD-L1 testing from cytology cell block samples obtained by bronchoscopic needle aspiration. The secondary objective was the assessment of the difference in specimen adequacy acquired via needles of different gauges. METHODS: Patients with NSCLC who underwent bronchoscopic needle aspirations for which PD-L1 testing was requested between November 1, 2016, and February 6, 2017, were included in the current analysis...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29041924/the-value-of-repeat-radial-probe-endobronchial-ultrasound-guided-transbronchial-biopsy-after-initial-non-diagnostic-results-in-patients-with-peripheral-pulmonary-lesions
#15
Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho, Chong-Jen Yu
BACKGROUND: Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be repeated because of initial non-diagnostic procedure(s). Little if any literature has been published on this issue. Therefore, the aim of this study was to investigate the utility of repeat rEBUS-guided TBB in achieving a definitive diagnosis of PPLs. METHODS: All patients who underwent rEBUS-guided TBB of PPLs at National Taiwan University Hospital between 2011 and 2015 and had a repeat procedure after non-diagnostic initial procedures were identified as the study subjects...
October 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29020679/a-preclinical-evaluation-comparing-the-performance-of-a-novel-19-g-flexible-needle-to-a-commercially-available-22-g-ebus-tbna-sampling-needle
#16
Kasia Czarnecka-Kujawa, Alain Tremblay, Kazuhiro Yasufuku, Anna Sczaniecka, Sujeeth Parthiban, Lawrence Kunz, David Dillard, Xavier Gonzalez
BACKGROUND: Needle samples may not provide sufficient diagnostic material for the assessment of mediastinal lymph nodes. OBJECTIVE: The study compared the specimen size and diagnostic performance of a new 19-G endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle to that of a standard 22-G EBUS-TBNA needle in a swine model of granulomatous lymphadenopathy. METHODS: Granulomatous inflammation was induced in mediastinal lymph nodes (LNs) of 10 domestic swine by injection of talc slurry...
October 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28976111/contribution-of-cell-blocks-obtained-through-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-the-determination-of-lung-cancer-subtypes
#17
Nilgün Yılmaz Demirci, Asiye Uğraş Dikmen, Zarife Abdullayeva, Can Öztürk
INTRODUCTION: It is crucial to diagnose the subtype of lung cancer quickly and accurately for effective therapy. Conventional cytology staining sometimes provides limited information, and additional tissue is often required to diagnose lung cancer. Cell blocks (CB) recovered during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) increases the diagnostic accuracy of the procedure and the likelihood of additional valuable histochemical and immunohistochemical staining...
October 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28967732/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-under-conscious-sedation-with-meperidine-and-midazolam
#18
Lorenzo Agostini, Nicola Facciolongo, Mirco Lusuardi, Eleonora Casalini, Carla Galeone, Luciano Lasagni, Luigi Zucchi
Endobronchial Ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is usually performed under general anesthesia or deep sedation with drugs such as Propofol that, at least in Italy, can be administered only by an anesthesiologist. Aim of the study was to assess conscious sedation feasibility, safety and tolerability using Meperidine and Midazolam as administered by Pulmonologist and relevant impact on the efficiency of the sampling procedures.All patients undergoing EBUS-TBNA from February 2013 to July 2014 were examined retrospectively...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28957889/conventional-transbronchial-needle-aspiration-the-original-guard-who-still-has-a-role-in-mediastinal-lymph-node-sampling
#19
Ravindra M Mehta, Abhinav Singla, Arjun Lakshmana Balaji, Shantha Krishnamurthy, Rajani S Bhat, Chakravarthi Lokanath
INTRODUCTION: Conventional transbronchial needle aspiration (C-TBNA) is the originally described method for sampling mediastinal lymph nodes (MLN). After the advent of endobronchial ultrasound, the practice and reports of C-TBNA have dwindled. We report a large series of C-TBNA from the Indian subcontinent, highlighting aspects such as pathological spectrum, yield and complications, and reiterating its relevance in MLN sampling. METHODS: The study population included 400 consecutive patients over 6...
October 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28951780/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-combining-with-immunohistochemistry-and-genotype-in-lung-cancer-a-single-center-55-cases-retrospective-study
#20
Aiqun Liu, Liwen Qian, Yi Zhong, Xiaoling Lu, Yongxiang Zhao
OBJECTIVE: The purpose of this study was to evaluate the utility of EBUS-TNA for mediastinal mass or suspected lung cancer patients with mediastinal or hilar lymph node enlarged. Further to investigate the clinical value of EBUS-TBNA combining with immunohistochemistry and genotype in lung cancer. METHODS: A total of 55 patients with mediastinal, and/or hilar lymphadenopathy, and/or mediastinal mass previously detected by CT or PET/CT scan and who underwent EBUS-TBNA...
November 2017: Annals of Medicine and Surgery
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