Daniël H van Raalte, Petter Bjornstad, David Z I Cherney, Ian H de Boer, Paola Fioretto, Daniel Gordin, Frederik Persson, Sylvia E Rosas, Peter Rossing, Jennifer A Schaub, Katherine Tuttle, Sushrut S Waikar, Hiddo J L Heerspink
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20-40% of patients with diabetes mellitus. As the global prevalence of diabetes has increased, DKD has become highly prevalent and a leading cause of kidney failure, accelerated cardiovascular disease, premature mortality and global health care expenditure. Multiple pathophysiological mechanisms contribute to DKD, and single lifestyle or pharmacological interventions have shown limited efficacy at preserving kidney function...
April 3, 2024: Nature Reviews. Nephrology