keyword
MENU ▼
Read by QxMD icon Read
search

rectum cancer

keyword
https://www.readbyqxmd.com/read/29239195/-immunotherapy-of-colorectal-and-anal-carcinoma
#1
J Tomášek, I Kiss
BACKGROUND: The lower part of the digestive tract includes the large intestine, rectum and anus. Treatment algorithms of cancers in these localities have significant differences in both early and advanced stages. The vast majority of metastatic cases are incurable. A few years ago, it was generally accepted that gastrointestinal tumors are poorly immunogenic and modern immunotherapy would not work in gastrointestinal cancers. The breakthrough has become the recognition of the mismatch repair system (MMR) that affects the microsatellite instability (MSI) and its role in the development of colorectal carcinoma (CRC)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29237218/-cylindric-abdominoperineal-rectum-exstirpation-with-partial-vulvar-and-vaginal-resection-as-well-as-perineal-and-vaginal-defect-reconstruction-by-a-vertical-rectus-abdominis-myocutaneous-vram-flap
#2
Christian Krautz, Klaus Weber, Roland Croner, Axel Denz, Matthias Maak, Raymund E Horch, Robert Grützmann
Introduction Patients with low rectal cancer or anal cancer undergoing abdominoperineal excision (APE) benefit from extended surgery and the subsequent avoidance of surgical "waisting" at the level of the puborectalis muscle. The method of cylindrical APE was introduced by T. Holm and led to a reduction of intraoperative perforations and involvement of circumferential resection margins, and subsequently reduced the risk of local recurrence. The use of myocutaneous flaps reduces perineal wound complications, which occur in up to 60% of patients with primary closure of perineal defects, especially following neoadjuvant radiochemotherapy...
December 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29234923/non-inferiority-multicenter-prospective-randomized-controlled-study-of-rectal-cancer-t2-t3s-superficial-n0-m0-undergoing-neoadjuvant-treatment-and-local-excision-tem-vs-total-mesorectal-excision-tme
#3
X Serra-Aracil, C Pericay, T Golda, L Mora, E Targarona, S Delgado, A Reina, F Vallribera, J M Enriquez-Navascues, S Serra-Pla, J C Garcia-Pacheco
PURPOSE: The standard treatment of rectal adenocarcinoma is total mesorectal excision (TME), in many cases requires a temporary or permanent stoma. TME is associated with high morbidity and genitourinary alterations. Transanal endoscopic microsurgery (TEM) allows access to tumors up to 20 cm from the anal verge, achieves minimal postoperative morbidity and mortality rates, and does not require an ostomy. The treatment of T2, N0, and M0 cancers remains controversial. Preoperative chemoradiotherapy (CRT) in association with TEM reduces local recurrence and increases survival...
December 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#4
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29233694/insight-of-nitric-oxide-signalling-a-potential-biomarker-in-bio-regulation-with-multifaceted-complex-mechanism-in-colorectal-carcinogenesis
#5
Paramita Mandal
Colorectal carcinogenesis (CRC) is the most important health concerns throughout the World as the tumour cells rapidly spread and abruptly grow in colon and rectum to further organs. Several etiological factors are associated with colorectal carcinogenesis. During invasion and proliferation of tumour cells, various mechanistic molecular pathways are involved in the cells. Nitric Oxide pathway (NO) is one of the important cellular mechanisms associated with tumour cells initiation, invasion and progression. Epidemiological evidences suggest that NO has potential role in development of cancer...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29229506/the-population-benefit-of-evidence-based-radiotherapy-5-year-local-control-and-overall-survival-benefits
#6
T P Hanna, J Shafiq, G P Delaney, S K Vinod, S R Thompson, M B Barton
BACKGROUND: To describe the population benefit of radiotherapy in a high-income setting if evidence-based guidelines were routinely followed. METHODS: Australian decision tree models were utilized. Radiotherapy alone (RT) benefit was defined as the absolute proportional benefit of radiotherapy compared with no treatment for radical indications, and of radiotherapy over surgery alone for adjuvant indications. Chemoradiotherapy (CRT) benefit was the absolute incremental benefit of concurrent chemoradiotherapy over RT...
December 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29223986/kras-testing-tumor-location-and-survival-in-patients-with-stage-iv-colorectal-cancer-seer-2010-2013
#7
Mary E Charlton, Amanda R Kahl, Alissa A Greenbaum, Jordan J Karlitz, Chi Lin, Charles F Lynch, Vivien W Chen
Purpose:KRAS mutations and tumor location have been associated with response to targeted therapy among patients with stage IV colorectal cancer (CRC) in various trials. This study performed the first population-based examination of associations between KRAS mutations, tumor location, and survival, and assessed factors associated with documented KRAS testing. Methods: Patients with stage IV adenocarcinoma of the colon/rectum diagnosed from 2010 to 2013 were extracted from SEER data. Analyses of patient characteristics, KRAS testing, and tumor location were conducted using logistic regression...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223302/modeling-the-target-dose-fall-off-in-imrt-and-vmat-planning-techniques-for-cervical-sbrt
#8
A Brito Delgado, D Cohen, T Y Eng, D N Stanley, Z Shi, M Charlton, A N Gutiérrez
There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle3 with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358° VMAT arcs (4° spacing), and (3) triple, non-coplanar VMAT arcs...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29219281/impact-on-sexual-function-of-surgical-treatment-in-rectal-cancer
#9
Pedro Costa, João M Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
INTRODUCTION: The development of new surgical techniques and medical devices, like therapeutical multimodal approaches has allowed for better outcomes on patients with rectal cancer (RCa). Owing to that, an increased awareness and investment towards better outcomes regarding patients' sexual and urinary function has been recently observed. AIM: Evaluate and characterize the sexual dysfunction of patients submitted to surgical treatment for RCa. MATERIALS AND METHODS: An observational retrospective study including all male patients who underwent a surgical treatment for RCa between January 2011 December 2014 (n=43) was performed, complemented with an inquiry questionnaire to every patient about its sexual habits and level of function before and after surgery...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29216565/incidence-prevalence-mortality-disability-adjusted-life-years-and-risk-factors-of-cancer-in-australia-and-comparison-with-oecd-countries-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#10
Yohannes Adama Melaku, Sarah L Appleton, Tiffany K Gill, Felix A Ogbo, Elizabeth Buckley, Zumin Shi, Tim Driscoll, Robert Adams, Benjamin C Cowie, Christina Fitzmaurice
BACKGROUND: Comparative evidence on the burden, trend, and risk factors of cancer is limited. Using data from the Global Burden of Disease (GBD) study, we aimed to assess cancer burden - incidence, prevalence, mortality, disability-adjusted life years (DALYs) - and attributable risk factors for Australia between 1990 and 2015, and to compare them with those of 34 members of the Organisation for Economic Co-operation and Development (OECD). METHODS: The general GBD cancer estimation methods were used with data input from vital registration systems and cancer registries...
December 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29215955/results-of-a-randomized-double-blind-placebo-controlled-phase-iii-trial-of-trifluridine-tipiracil-tas-102-monotherapy-in-asian-patients-with-previously-treated-metastatic-colorectal-cancer-the-terra-study
#11
Jianming Xu, Tae Won Kim, Lin Shen, Virote Sriuranpong, Hongming Pan, Ruihua Xu, Weijian Guo, Sae-Won Han, Tianshu Liu, Young Suk Park, Chunmei Shi, Yuxian Bai, Feng Bi, Joong Bae Ahn, Shukui Qin, Qi Li, Changping Wu, Dong Ma, Donghu Lin, Jin Li
Purpose Trifluridine/tipiracil (TAS-102) was effective in patients with metastatic colorectal cancer (mCRC) in a phase II Japanese trial. This regional trial evaluated the efficacy and safety of trifluridine/tipiracil in Asian patients with mCRC with or without exposure to biologic therapy. Patients and Methods This randomized, double-blind, placebo-controlled, phase III trial was conducted at 30 sites in China, the Republic of Korea, and Thailand. Patients ≥ 18 years old with histologically or cytologically confirmed adenocarcinoma of the colon or rectum and known KRAS status who were refractory or intolerant to two or more prior chemotherapy regimens were enrolled...
December 7, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29215480/optimal-surveillance-protocols-after-curative-resection-in-patients-with-stage-iv-colorectal-cancer-a-multicenter-retrospective-study
#12
Tomokazu Kishiki, Brittany Lapin, Hiroyoshi Matsuoka, Takeshi Watanabe, Kohei Takayasu, Koichiro Kojima, Kenichi Sugihara, Tadahiko Masaki
BACKGROUND: After patients with stage IV colorectal cancer undergo curative surgical resection, there is a large risk for recurrence. To establish optimal surveillance guidelines, an understanding of the temporal risk factors for recurrence is necessary. OBJECTIVE: The primary aim of our study was to determine predictors for early (within 1 year), middle (1-2 years), and late (2 years or later) recurrence following curative resection in patients with stage IV colorectal cancer...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29212105/-german-society-of-gastroenterology-digestive-and-metabolic-diseases-dgvs-position-statement-on-endoscopic-decompression-in-acute-ileus
#13
Martin Götz, Georg Braun, Ralf Jakobs, Helmut Messmann, Eduard F Stange, Markus M Lerch
In patients with ileus with dilated intestine in imaging studies, endoscopic decompression appears a feasible option. However, its use is often uncritical and without scientific evidence. Before considering endoscopic intervention, CT-imaging should differentiate between mechanical obstruction and paralytic ileus/intestinal pseudo-obstruction. Tumor diagnosis and localisation are essential because the latter determines the choice of the decompression procedure. Coecal dilatation of more than 12 cm indicates an increased risk of perforation...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29209524/heterogeneity-of-colon-cancer-from-bench-to-bedside
#14
REVIEW
Marco C Merlano, Cristina Granetto, Elena Fea, Vincenzo Ricci, Ornella Garrone
The large bowel shows biomolecular, anatomical and bacterial changes that proceed from the proximal to the distal tract. These changes account for the different behaviour of colon cancers arising from the diverse sides of the colon-rectum as well as for the sensitivity to the therapy, including immunotherapy. The gut microbiota plays an important role in the modulation of the immune response and differs between the right colon cancer and the left colorectal cancer. The qualitative and quantitative difference of the commensal bacteria between the right side and the left side induces epigenetic changes in the intestinal epithelial cells as well as in the resident immune population...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#15
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207634/treatment-plan-comparison-between-tri-co-60-magnetic-resonance-image-guided-radiation-therapy-and-volumetric-modulated-arc-therapy-for-prostate-cancer
#16
Jong Min Park, So-Yeon Park, Chang Heon Choi, Minsoo Chun, Jin Ho Kim, Jung-In Kim
To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) with magnetic-resonance image-guided radiation therapy compared with volumetric-modulated arc therapy (VMAT) for prostate cancer. Twenty patients with intermediate-risk prostate cancer, who received radical VMAT were selected. Additional tri-Co-60 IMRT plans were generated for each patient. Both primary and boost plans were generated with tri-Co-60 IMRT and VMAT techniques. The prescription doses of the primary and boost plans were 50...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206231/cancer-type-dependent-expression-of-ck2-transcripts
#17
Melissa M J Chua, Migi Lee, Isabel Dominguez
A multitude of proteins are aberrantly expressed in cancer cells, including the oncogenic serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript expression that could explain the increased CK2 protein levels found in tumors from lung and bronchus, prostate, breast, colon and rectum, ovarian and pancreatic cancers. We also found that, contrary to the current notions about CK2, some CK2 transcripts were downregulated in several cancers. Here, we investigate all other cancers using Oncomine to determine whether they also display significant CK2 transcript dysregulation...
2017: PloS One
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#18
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29204165/throwing-the-dart-blind-folded-comparison-of-computed-tomography-versus-magnetic-resonance-imaging-guided-brachytherapy-for-cervical-cancer-with-regard-to-dose-received-by-the-actual-targets-and-organs-at-risk
#19
Winnie Wing Ling Yip, Joyce Siu Yu Wong, Venus Wan Yan Lee, Frank Chi Sing Wong, Stewart Yuk Tung
Purpose: Computed tomography (CT) is inferior to magnetic resonance imaging (MRI) in cervical tumor delineation, but similar in identification of organs at risk (OAR). The trend to over-estimate high-risk and low-risk clinical target volume (HRCTV, IRCTV) on CT can lead to under-estimation of dose received by 90% (D90) of the 'actual' CTV. This study aims to evaluate whether CT-guided planning delivers adequate dose to the 'actual' targets while spares the OAR similarly. Material and methods: MRI-guided high-dose-rate image-guided brachytherapy (IGBT) was performed in 11 patients...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29204164/comparison-of-dose-volume-parameters-evaluated-using-three-forward-planning-optimization-techniques-in-cervical-cancer-brachytherapy-involving-two-applicators
#20
Bikramjit Chakrabarti, Somapriya Basu-Roy, Sanjay Kumar Kar, Sounik Das, Annesha Lahiri
Purpose: This study is intended to compare dose-volume parameters evaluated using different forward planning- optimization techniques, involving two applicator systems in intracavitary brachytherapy for cervical cancer. It looks for the best applicator-optimization combination to fulfill recommended dose-volume objectives in different high-dose-rate (HDR) fractionation schedules. Material and methods: We used tandem-ring and Fletcher-style tandem-ovoid applicator in same patients in two fractions of brachytherapy...
October 2017: Journal of Contemporary Brachytherapy
keyword
keyword
44004
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"