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https://www.readbyqxmd.com/read/28734642/extreme-hypofractionation-for-high-risk-prostate-cancer-dosimetric-correlations-with-rectal-bleeding
#1
Glenn Bauman, Jeff Chen, George Rodrigues, Melanie Davidson, Andrew Warner, Andrew Loblaw
PURPOSE: We explored the association of dosimetric parameters with late rectal bleeding among high-risk prostate cancer patients treated with hypofractionated simultaneous in-field boost (H-SIB) to prostate with nodal treatment. METHODS AND MATERIALS: Rectal toxicity results and dose-volume histogram (DVH) information from patients treated on FASTR and SATURN were combined. Patients in both trials received long-term androgen deprivation and H-SIB with prescription dose 40 Gy to the prostate and proximal seminal vesicles and 25 Gy to the lymph nodes delivered over 5 weekly fractions using image guidance with cone beam computed tomography...
June 9, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28733526/investigation-of-methylenetetrahydrofolate-reductase-tagging-polymorphisms-with-colorectal-cancer-in-chinese-han-population
#2
Sheng Zhang, Shuchen Chen, Yu Chen, Mingqiang Kang, Chao Liu, Hao Qiu, Yafeng Wang, Weifeng Tang
The aim of this case-control study was to assess the relationship between the tagging polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to colorectal cancer (CRC) in a Chinese Han population. A custom-by-design 48-Plex SNPscan Kit was used to determine the genotypes of MTHFR rs3753584 T>C, rs9651118 T>C, rs1801133 G>A, rs4846048 A>G and rs4845882 G>A polymorphisms in 387 CRC patients and 1,536 non-cancer controls. The results revealed that MTHFR rs1801133 G>A polymorphism was associated with a decreased risk of overall CRC...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731950/totally-laparoscopic-resection-for-low-sigmoid-and-rectal-cancer-using-natural-orifice-specimen-extraction-techniques
#3
Hideharu Shimizu, Kensuke Adachi, Hideo Ohtsuka, Itaru Osaka, Kunio Takuma, Kijuro Takanishi, Jun Matsumoto
BACKGROUND: A minilaparotomy for specimen extraction during laparoscopy occasionally results in postoperative wound complications. We have performed a totally laparoscopic resection for early colorectal cancer using the natural orifice specimen extraction technique. METHODS: From 2008 to 2013, we have performed a totally laparoscopic resection for clinical stage I and IIA low sigmoid colon and rectal cancers. A prospectively maintained database was reviewed to assess the outcomes after surgery...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28730678/prognosis-following-cancer-surgery-during-holiday-periods
#4
Jesper Lagergren, Fredrik Mattsson, Pernilla Lagergren
Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long-term prognosis than for non-holiday periods. This nationwide Swedish population-based cohort study included 228,927 patients during 1997-2014 who underwent elective resectional surgery for a cancer where the annual number of resections was over 100. The 16 eligible cancer sites were grouped into 10 cancer groups. The exposure, holiday periods, was classified as wide (14-weeks) or narrow (7-weeks)...
July 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28725253/computed-tomography-based-treatment-planning-for-high-dose-rate-brachytherapy-using-the-tandem-and-ring-applicator-influence-of-applicator-choice-on-organ-dose-and-inter-fraction-adaptive-planning
#5
REVIEW
Vishruta A Dumane, Yading Yuan, Ren-Dih Sheu, Vishal Gupta
Three dimensional planning for high-dose-rate (HDR) brachytherapy in cervical cancer has been highly recommended by consensus guidelines such as the American Brachytherapy Society (ABS) and the Groupe Européen de Curiethérapie - European Society for Radiotherapy and Oncology (GEC-ESTRO). In this document, we describe our experience with computed tomography (CT)-based planning using the tandem/ring applicator. We discuss the influence of applicator geometry on doses to organs at risk (OARs), namely the bladder, rectum, and sigmoid...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28725245/the-usefulness-of-fleet-rectal-enemas-on-high-dose-rate-intracavitary-cervical-cancer-brachytherapy-a-prospective-trial
#6
Ignacio Andres, Manuel Gutierrez-Perez, Maria Pilar Rodriguez-Vela, Roberto Berenguer, Marimar Sevillano, Manuel Aguayo, Meritxell Arenas, Angeles Rovirosa, Yashmina Murria-Perez, Sebastia Sabater
PURPOSE: To evaluate the effects of rectal enemas on rectal doses during radical high-dose-rate (HDR) intracavitary cervical brachytherapy (BT). MATERIAL AND METHODS: Twenty patients suffering from cervical cancer and treated with external beam radiotherapy and HDR-BT were included in a prospective trial. The first brachytherapy fraction was considered the basal status, and patients were instructed to self-administer two rectal cleansing enemas before the second fraction...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28722085/-anatomical-planes-and-landmarks-of-transanal-total-mesorectal-excision-for-rectal-cancer-and-prophylaxis-of-intraoperative-complications
#7
Zhanlong Shen, Yingjiang Ye, Shan Wang
Total mesorectal excision (TME) is a mile-stone procedure in the history of rectal cancer surgery, but the exposure of surgical field of distal rectum is usually poor in patients with male, obese and narrow pelvis, which may lead to tumor residue and relative complications. Recently, a new technique called transanal TME (taTME) is considered to solve the above problems, but most medical centers are still in the learning curve of this procedure. Therefore, anatomical planes and landmarks of taTME for rectal cancer and prophylaxis of intraoperative complications are induced in this paper, which includes posterior plane: angle of anus and distal mesorectum and bleeding of mesorectum; rectosacral fascia and presacral bleeding; lateral and posterior-lateral plane: posterior branches of pelvic plexus and damage of anal function; anterior plane: vessel branches of neurovascular bundle and bleeding...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28720267/a-systematic-review-of-the-supportive-care-needs-of-people-living-with-and-beyond-cancer-of-the-colon-and-or-rectum
#8
REVIEW
Grigorios Kotronoulas, Constantina Papadopoulou, Kathryn Burns-Cunningham, Mhairi Simpson, Roma Maguire
PURPOSE: Gaining a clear understanding of the health needs and concerns of people with cancer of the colon and/or rectum can help identify ways to offer a comprehensive care package. Our aim was to systematically assess the relevant literature and synthesise current available evidence. METHODS: A systematic review was conducted according to the PRISMA Statement guidelines. Five electronic databases were searched to identify studies employing qualitative and/or quantitative methods...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28718071/cancer-survival-in-adult-patients-in-spain-results-from-nine-population-based-cancer-registries
#9
M D Chirlaque, D Salmerón, J Galceran, A Ameijide, A Mateos, A Torrella, R Jiménez, N Larrañaga, R Marcos-Gragera, E Ardanaz, M Sant, P Minicozzi, C Navarro, M J Sánchez
INTRODUCTION: With the aim of providing cancer control indicators, this work presents cancer survival in adult (≥15 years) patients in Spain diagnosed during the period 2000-2007 from Spanish cancer registries participating in the EUROCARE project. METHODS: Cancer cases from nine Spanish population-based cancer registries were included and analysed as a whole. All primary malignant neoplasms diagnosed in adult patients were eligible for the analysis. Cancer patients were followed until 31 December 2008...
July 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28716090/clinical-workflow-for-mr-only-simulation-and-planning-in-prostate
#10
Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos, Margie Hunt
PURPOSE: To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients. METHODS: Forty-eight prostate cancer patients from June 2016 - Dec 2016 receiving external beam radiotherapy were scheduled to undergo MR-only simulation. MR images were acquired for contouring (T2w axial, coronal, sagittal), synthetic-CT generation (3D FFE-based) and fiducial identification (3D bFFE-based). The total acquisition time was 25 min...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28714458/a-graphical-approach-to-optimizing-variable-kernel-smoothing-parameters-for-improved-deformable-registration-of-ct-and-cone-beam-ct-images
#11
Vern Hart, Damon Burrow, X Allen Li
A systematic method is presented for determining optimal parameters in variable-kernel deformable image registration of cone beam CT and CT images, in order to improve accuracy and convergence for potential use in online adaptive radiotherapy. Assessed conditions included the noise constant (symmetric force demons), the kernel reduction rate, the kernel reduction percentage, and the kernel adjustment criteria. Four such parameters were tested in conjunction with reductions of 5, 10, 15, 20, 30, and 40%. Noise constants ranged from 1...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28712717/radiobiological-evaluation-of-prostate-cancer-imrt-and-conformal-rt-plans-using-different-treatment-protocols
#12
Panayiotis Mavroidis, Georgios Komisopoulos, Courtney Buckey, Margarita Mavroeidi, Gregory P Swanson, Dimos Baltas, Nikos Papanikolaou, Sotirios Stathakis
The purpose of this study is to evaluate the clinical efficacy of both step-and-shoot IMRT and 3D-Conformal Radiation Therapy modalities (CRT) in treating prostate cancer using radiobiological measures. Another aim was to estimate the risks for developing secondary malignancies in bladder and rectum due to radiotherapy from the corresponding modalities. The treatment plans of ten prostate cancer patients were developed using IMRT and CRT. For the IMRT plans, two beam energies and two treatment protocols were used (the RTOG 0415 and a most restrictive one proposed by Fox Chase Cancer Center (FCCC))...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28711649/intramucosal-colorectal-carcinoma-with-invasion-of-the-lamina-propria-a-study-by-the-japanese-society-for-cancer-of-the-colon-and-rectum
#13
Motohiro Kojima, Hideyuki Shimazaki, Keiichi Iwaya, Takahiro Nakamura, Hiroshi Kawachi, Kazuhito Ichikawa, Shigeki Sekine, Shingo Ishiguro, Tadakazu Shimoda, Ryoji Kushima, Takashi Yao, Takahiro Fujimori, Kazuo Hase, Toshiaki Watanabe, Kenichi Sugihara, Gregory Y Lauwers, Atsushi Ochiai
Cancer invasion of the lamina propria is an important pathological finding. However, the clinicopathologic features and diagnostic accuracy of intramucosal carcinoma assessment in colorectal carcinoma (CRC) are unknown. In this study, intramucosal CRCs were reviewed in institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum, and 32 cases with invasion of the lamina propria were identified. Next, a consensus meeting was held to select cases with a high consensus about the presence of invasion, which were reviewed by one Western pathologist for confirmation...
July 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28711481/simultaneous-integrated-boost-sib-for-treatment-of-gynecologic-carcinoma-intensity-modulated-radiation-therapy-imrt-vs-volumetric-modulated-arc-therapy-vmat-radiotherapy
#14
Irina Vergalasova, Kim Light, Junzo Chino, Oana Craciunescu
The aim of this study was to quantitatively compare dosimetric criteria between intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans for patients undergoing radiation treatment of gynecologic carcinoma with a simultaneous integrated boost (SIB) technique. IMRT and VMAT plans were retrospectively analyzed for 20 patients. The elective volume was planned to receive 45 Gy in 25 fractions of 1.8 Gy, with the integrated boost volume (involved nodes) receiving 55 Gy simultaneously...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28707036/treatment-strategies-for-rectal-cancer-with-synchronous-liver-metastases-surgical-and-oncological-outcomes-with-propensity-score-analysis
#15
H Salvador-Rosés, S López-Ben, P Planellas, E Canals, M Casellas-Robert, R Farrés, E Ramos, A Codina-Cazador, J Figueras
BACKGROUND: The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial. OBJECTIVES: The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors. METHODS: Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score)...
July 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28706185/deep-learning-for-fully-automated-localization-and-segmentation-of-rectal-cancer-on-multiparametric-mr
#16
Stefano Trebeschi, Joost J M van Griethuysen, Doenja M J Lambregts, Max J Lahaye, Chintan Parmer, Frans C H Bakers, Nicky H G M Peters, Regina G H Beets-Tan, Hugo J W L Aerts
Multiparametric Magnetic Resonance Imaging (MRI) can provide detailed information of the physical characteristics of rectum tumours. Several investigations suggest that volumetric analyses on anatomical and functional MRI contain clinically valuable information. However, manual delineation of tumours is a time consuming procedure, as it requires a high level of expertise. Here, we evaluate deep learning methods for automatic localization and segmentation of rectal cancers on multiparametric MR imaging. MRI scans (1...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705507/dosimetric-comparison-of-rapidplan-and-manually-optimized-plans-in-volumetric-modulated-arc-therapy-for-prostate-cancer
#17
Kazuki Kubo, Hajime Monzen, Kentaro Ishii, Mikoto Tamura, Ryu Kawamorita, Iori Sumida, Hirokazu Mizuno, Yasumasa Nishimura
PURPOSE: This study evaluated whether RapidPlan based plans (RP plans) created by a single optimization, are usable in volumetric modulated arc therapy (VMAT) for patients with prostate cancer. METHODS: We used 51 previously administered VMAT plans to train a RP model. Thirty RP plans were created by a single optimization without planner intervention during optimization. Differences between RP plans and clinical manual optimization (CMO) plans created by an experienced planner for the same patients were analyzed (Wilcoxon tests) in terms of homogeneity index (HI), conformation number (CN), D95%, and D2% to planning target volume (PTV), mean dose, V50Gy, V70Gy, V75Gy, and V78Gy to rectum and bladder, monitor unit (MU), and multi-leaf collimator (MLC) sequence complexity...
July 10, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28705205/clinicopathological-features-and-prognosis-of-gastroenteropancreatic-neuroendocrine-neoplasms-in-a-chinese-population-a-large-retrospective-single-centre-study
#18
Meng Zhang, Ping Zhao, Xiaodan Shi, Ahong Zhao, Lianfeng Zhang, Lin Zhou
BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective study in our center to investigate the clinicopathological features, risk factors of metastasis, and prognosis of GEP-NENs in a Chinese population. METHODS: Four hundred forty patients with GEP-NENs treated at the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2016 were analyzed retrospectively...
July 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28694116/effect-of-bladder-distension-on-doses-to-organs-at-risk-in-pulsed-dose-rate-3d-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#19
Jean Philippe Nesseler, Claire Charra-Brunaud, Julia Salleron, Jean François Py, Andres Huertas, Emilie Meknaci, Florent Courrech, Didier Peiffert, Sophie Renard-Oldrini
PURPOSE: To evaluate the impact of bladder distension on doses to organs at risk in patients treated with 3D image-guided adaptive pulsed-dose-rate (PDR) brachytherapy (BT) for locally advanced cervical cancer. METHODS AND MATERIALS: Twenty-two patients who had previously been treated by external beam radiation therapy (EBRT), underwent BT treatment planning to a pelvic MRI (or a CT scan in case of contraindication) after their bladder was filled with 100 cc of physiological saline (full bladder)...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28691047/location-of-colorectal-cancer-colonoscopy-versus-surgery-yield-of-colonoscopy-in-predicting-actual-location
#20
Juan Pablo Blum-Guzman, Silvio Wanderley de Melo
BACKGROUND AND STUDY AIMS:  Recent studies suggest that differences in biological characteristics and risk factors across cancer site within the colon and rectum may translate to differences in survival. It can be challenging at times to determine the precise anatomical location of a lesion with a luminal view during colonoscopy. The aim of this study is to determine if there is a significant difference between the location of colorectal cancers described by gastroenterologists in colonoscopies and the actual anatomical location noted on operative and pathology reports after colon surgery...
July 2017: Endoscopy International Open
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