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https://www.readbyqxmd.com/read/28078471/effects-of-estrogen-on-esophageal-function-through-regulation-of-ca-2-related-proteins
#1
Kipung Kim, Dongoh Lee, Changhwan Ahn, Hee Young Kang, Beum-Soo An, Yeon Hee Seong, Eui-Bae Jeung
BACKGROUND: The calcium ion is important for physiological functions in all tissues and organs and essential to many vital functions, including hormone secretion and muscle contraction. The intracellular concentration of calcium is regulated by calcium related proteins such as CaBP-9k, PMCA1, and NCX1. In this study, we investigated the relationship between calcium regulation and esophageal functions such as mucin secretion and smooth muscle contraction. METHODS: To evaluate the influence of sex steroid hormones, immature rats were treated for 3 days with estradiol (E2), progesterone (P4), and their antagonists (ICI 182,780, and RU486)...
January 11, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28075104/esophageal-cancer
#2
Matthew W Short, Kristina G Burgers, Vincent T Fry
Esophageal cancer has a poor prognosis and high mortality rate, with an estimated 16,910 new cases and 15,910 deaths projected in 2016 in the United States. Squamous cell carcinoma and adenocarcinoma account for more than 95% of esophageal cancers. Squamous cell carcinoma is more common in nonindustrialized countries, and important risk factors include smoking, alcohol use, and achalasia. Adenocarcinoma is the predominant esophageal cancer in developed nations, and important risk factors include chronic gastroesophageal reflux disease, obesity, and smoking...
January 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28068730/impaired-bolus-clearance-in-combined-high-resolution-esophageal-manometry-and-impedance-measurement-helps-to-differentiate-between-esophagogastric-junction-outflow-obstruction-and-achalasia
#3
Eugen Zizer, Thomas Seufferlein, Mark Martin Hänle
Introduction and aims High-resolution esophageal manometry (HRM) has improved the diagnostic work-up of esophageal motility disorders. Simultaneous evaluation of bolus clearance delivers useful information about the function of tubular esophagus. We assessed bolus clearance in a combined HRM-impedance examination for esophagogastric junction outflow obstruction (EGJOO) in comparison to achalasia patients. The collected data were assessed in a retrospective analysis. Patients and methods After gastroscopy excluded a mechanical esophageal or gastric obstruction, 142 consecutive patients underwent combined HRM-impedance examination...
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28063972/a-rare-case-of-esophageal-verrucous-squamous-cell-carcinoma-in-a-patient-with-achalasia
#4
R E Pouw, B A J Bastiaansen, B L A M Weusten
No abstract text is available yet for this article.
January 4, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28052278/diagnosis-and-treatment-strategy-of-achalasia-subtypes-and-esophagogastric-junction-outflow-obstruction-based-on-high-resolution-manometry
#5
Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Kazuhiko Nakamura
BACKGROUND: Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, endoscopic pneumatic dilation (PD), laparoscopic Heller myotomy (LHM), and per-oral endoscopic myotomy (POEM) are usually the sought-after modes of treatment. Since the etiology and pathogenesis might vary depending on the types of EGJOO disorders, treatment strategies should be considered based on those subtypes...
2017: Digestion
https://www.readbyqxmd.com/read/28050913/technological-review-on-endoscopic-submucosal-dissection-available-equipment-recent-developments-and-emerging-techniques
#6
Georgios Mavrogenis, Juergen Hochberger, Pierre Deprez, Morteza Shafazand, Dimitri Coumaros, Katsumi Yamamoto
Endoscopic submucosal dissection (ESD) is widely practiced in Japan and the Eastern World and is rapidly expanding in western countries for the management of early malignancies of the upper and lower gastrointestinal tube. In addition, novel therapeutic applications deriving from ESD have emerged including the treatment of achalasia, of submucosal tumors, of diverticula, of strictures and of reflux disease. An ESD procedure necessitates not only skills and specific training, but also familiarization with a vast spectrum of devices (endoscopes, high-frequency generators and their settings, endoknives, hoods, irrigation devices) and techniques (such as countertraction, artificial ulcer closure), that render the procedure faster, more efficient and safer...
January 4, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28050248/management-of-achalasia-in-the-uk-do-we-need-new-guidelines
#7
REVIEW
Jihene El Kafsi, Antonio Foliaki, Thomas C B Dehn, Nicholas D Maynard
AIM: It is recommended that management of complex benign upper gastrointestinal pathology is discussed at multi disciplinary team (MDT) meetings. American College of Gastroenterology (ACG) guidelines further recommend that treatment delivery is provided by high volume centres, with objective post-procedural investigations, in order to improve patient outcomes. We aimed to survey the current UK practice in the management of achalasia. METHODS: 443 Upper gastrointestinal (UGI) specialist surgeons throughout the UK were sent a surveymonkey...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28039638/effects-of-laparoscopic-myotomy-on-the-esophageal-motility-pattern-of-esophageal-achalasia-as-measured-by-high-resolution-manometry
#8
Renato Salvador, Edoardo Savarino, Elisa Pesenti, Lorenzo Spadotto, Guerrino Voltarel, Giovanni Capovilla, Francesco Cavallin, Loredana Nicoletti, Michele Valmasoni, Alberto Ruol, Stefano Merigliano, Mario Costantini
BACKGROUND: Esophageal achalasia can be classified on the grounds of three distinct manometric patterns that correlate well with final outcome after laparoscopic Heller-Dor myotomy (LHM). No analytical data are available, however, on the postoperative picture and its possible correlation with final outcome. The aims of this study were: (a) to investigate whether manometric patterns change after LHM for achalasia; (b) to ascertain whether postoperative patterns and/or changes can predict final outcome; and (c) to test the hypothesis that the three known patterns represent different stages in the evolution of the disease...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28011013/health-related-quality-of-life-after-laparoscopic-heller-myotomy-and-dor-fundoplication-for-achalasia
#9
Emanuele Asti, Andrea Sironi, Andrea Lovece, Giulia Bonavina, Melania Fanelli, Gianluca Bonitta, Luigi Bonavina
BACKGROUND: In addition to symptom scores, a person's perception of health and quality of life assessment is an important indicator of quality of treatment and can provide an efficient index to compare different therapeutic modalities in chronic disease states. Only a few studies have investigated quality of life comprehensively in patients with achalasia, and therefore the controversy regarding the best treatment algorithm continues. The primary study outcome was pre- and postoperative quality of life in patients with achalasia undergoing laparoscopic Heller myotomy and Dor fundoplication...
December 20, 2016: Surgery
https://www.readbyqxmd.com/read/28009686/etiology-and-pathogenesis-of-idiopathic-achalasia
#10
Amanda Pressman, Jose Behar
This review examines the etiology and pathogenesis of idiopathic achalasia. This disease is clinically characterized by dysphagia of solids and liquids due to the presence of simultaneous or absent esophageal contractions and impaired or absent relaxation of the lower esophageal sphincter. It includes a review of (a) etiology and pathogenesis of this inflammatory process that damage the ganglion cells of the Auerbach plexus that is limited to the esophagus; (b) genetic abnormalities and polymorphisms associated with this disease that may help explain its heterogeneity expressed by the different motility abnormalities of its phenotypes as well as differences in its clinical progression...
December 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28005192/the-robotic-approach-for-enucleation-of-a-giant-esophageal-lipoma
#11
Cheng-Hung How, Jang-Ming Lee
An 87-year-old man, who had been experiencing progressive dysphagia and slight chest discomfort for 12 months, presented for an esophagram with a diagnosis of achalasia. A giant esophageal lipoma (14.5- × 4.5- × 3.5-cm) that caused symptomatic dysphagia and a dilated esophagus was revealed by computed tomography and endoscopic esophageal ultrasound. For such a huge esophageal lipoma in a geriatric patient, we successfully enucleated the mediastinal lesion via a minimally invasive approach using the da Vinci S Surgical System...
December 22, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27981296/massive-food-impaction-in-achalasia
#12
Marco Silva, Armando Peixoto, Rosa Ramalho, Guilherme Macedo
No abstract text is available yet for this article.
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27976805/mutations-in-crlf1-cause-familial-achalasia
#13
Anne Busch, Milena Žarković, Chrishanthi Lowe, Martin Jankofsky, Rainer Ganschow, Insa Buers, Ingo Kurth, Heiko Reutter, Frank Rutsch, Christian A Hübner
We here report a family from Libya with 3 siblings suffering from early onset achalasia born to healthy parents. We analyzed roughly 5,000 disease-associated genes by a next generation sequencing approach. In the analyzed sibling we identified 2 heterozygous variants in CRLF1 (Cytokine Receptor-Like Factor 1). Mutations in CRLF1 have been associated with autosomal recessive Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1), which among other symptoms also manifests with early onset feeding difficulties...
December 15, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27973949/robot-assisted-heller-s-myotomy-for-achalasia-in-children
#14
Tariq Altokhais, Hala Mandora, Ayed Al-Qahtani, Abdulrahman Al-Bassam
BACKGROUND: Achalasia is rare in children. Surgical options include open, laparoscopic and robotic approaches. However, Heller's myotomy remains the treatment of choice. This report describes our experience with robot-assisted Heller's myotomy in children and presents a review of the literature. METHODS: Included in this study are children who underwent robot-assisted Heller's myotomy for esophageal achalasia via the Da Vinci surgical system between 2004 and 2015 at King Saud University Medical City, Riyadh, Saudi Arabia...
December 2016: Comput Assist Surg (Abingdon)
https://www.readbyqxmd.com/read/27967203/peroral-endoscopic-myotomy-for-an-achalasia-patient-with-multiple-esophageal-diverticula
#15
Yuyong Tan, Hongyi Zhu, Deliang Liu
Peoral endoscopic myotomy (POEM) has been proved to be safe and effective for treating achalasia, however the presence of esophageal diverticulum would increase the technical difficulty. In this letter, we firstly report a case regarding POEM for achalasia with concomitant multiple esophageal diverticulums.
December 14, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27966122/-current-diagnosis-and-therapy-of-achalasia
#16
REVIEW
Ines Gockel, Stefan Niebisch, Jessica Becker, Johannes Schumacher, Michaela Müller
No abstract text is available yet for this article.
December 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27939056/laparoscopic-myotomy-after-transjugular-intrahepatic-portosystemic-shunt-placement-and-embolization-of-gastroesophageal-varices-in-patients-with-achalasia-and-cirrhosis
#17
Unai de Andres Olabarria, Soledad Ugarte Sierra, Roberto Maniega Alba, Igor Alberdi San Roman, Francisco Javier Ibáñez Aguirre
No abstract text is available yet for this article.
December 8, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27938784/surveillance-of-patients-at-high-risk-of-squamous-cell-esophageal-cancer
#18
REVIEW
A Chaber-Ciopinska, D Kiprian, A Kawecki, M F Kaminski
Currently curative treatment for esophageal squamous cell cancer (ESCC) is possible only in patients with early-stage, usually asymptomatic disease. In Western countries, where the incidence of ESCC is relatively low, a screening of asymptomatic, average-risk population is untenable. In order to detect early-stage ESCC or its precursor lesions it is important to identify high-risk patients and consider endoscopic surveillance in these groups. These high-risk groups include patients after curative treatment for head and neck cancer, previous endoscopic resection of ESCC, caustic injury, and patients with tylosis or achalasia...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27928603/-laparoscopic-heller-myotomy-after-failed-poem-and-multiple-balloon-dilatations-better-late-than-never
#19
L Giulini, A Dubecz, H J Stein
BACKGROUND: Despite the lack of long-term results, peroral endoscopic myotomy (POEM) has been increasingly propagated as a feasible alternative to pneumatic balloon dilatation (BD) and laparoscopic Heller myotomy (LHM) in patients with achalasia. After a long-term follow-up, a large percentage of patients reported recurrence of dysphagia. It is unclear which kind of procedure (redo POEM or LHM) should be utilized in these patients with failed POEM. CASE REPORT AND RESULTS: We report the case of a 37-year-old female patient with type I achalasia who was successfully treated with LHM after a failed POEM procedure...
December 7, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27925255/the-course-of-achalasia-one-to-four-decades-after-initial-treatment
#20
T Sawas, K Ravi, D M Geno, F Enders, K Pierce, D Wigle, D A Katzka
BACKGROUND: Most follow-up studies of achalasia are limited to <5 years. AIMS: To study the long-term efficacy of pneumatic dilation (PD) and myotomy in achalasia at least 10 years after treatment. METHODS: We performed a retrospective cohort study of achalasia patients with >10 years follow-up after initial myotomy or pneumatic dilation. Symptom recurrence which required repeat dilation or surgery was compared between pneumatic dilation and myotomy...
December 7, 2016: Alimentary Pharmacology & Therapeutics
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