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https://www.readbyqxmd.com/read/29151255/weight-disorders-in-short-children
#1
Paweł Tomaszewski, Anna Majcher, Katarzyna Milde, Romuald Stupnicki
This study aimed to determine the degree of adiposity and prevalence of weight disorders in short children and to assess relationships between selected birth parameters and actual body fat content and body mass indicators. The study encompassed 85 girls and 97 boys, aged 7-14 years, with height below the 10th centile of the age and sex standard. In addition, 609 normal-height children (height between 25th and 75th centile) served as a comparison group. The children underwent measurements of body mass and height, skinfold thickness, and waist circumference...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29151248/adiponectin-and-vitamin-d-binding-protein-are-independently-associated-at-birth-in-both-mothers-and-neonates
#2
Spyridon N Karras, Stergios Α Polyzos, Danforth A Newton, Carol L Wagner, Bruce W Hollis, Jody van den Ouweland, Erdinc Dursun, Duygu Gezen-Ak, Kalliopi Kotsa, Cedric Annweiler, Declan P Naughton
CONTEXT: Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines-adiponectin and irisin-which have been reported to interact but, as yet, data remain controversial. OBJECTIVE: To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes...
November 18, 2017: Endocrine
https://www.readbyqxmd.com/read/29150892/expanding-the-neurodevelopmental-phenotype-of-pura-syndrome
#3
Bo Hoon Lee, Margot R F Reijnders, Oluwatobi Abubakare, Emily Tuttle, Brynn Lape, Kelly Q Minks, Christopher Stodgell, Loisa Bennetto, Jennifer Kwon, Chin-To Fong, Karen W Gripp, Eric D Marsh, Wendy E Smith, Ahm M Huq, Stephanie A Coury, Wen-Hann Tan, Orestes Solis, Rupal I Mehta, Richard J Leventer, Diana Baralle, David Hunt, Alex R Paciorkowski
PURA syndrome is a recently described developmental encephalopathy presenting with neonatal hypotonia, feeding difficulties, global developmental delay, severe intellectual disability, and frequent apnea and epilepsy. We describe 18 new individuals with heterozygous sequence variations in PURA. A neuromotor disorder starting with neonatal hyptonia, but ultimately allowing delayed progression to walking, was present in nearly all individuals. Congenital apnea was present in 56% during infancy, but all cases in this cohort resolved during the first year of life...
November 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29150869/maternal-mood-disorders-and-lithium-exposure-in-utero-were-not-associated-with-poor-cognitive-development-during-childhood
#4
L Forsberg, M Adler, I Römer Ek, M Ljungdahl, L Navér, L L Gustafsson, G Berglund, A Chotigasatien, U Hammar, B Böhm, K Wide
AIM: This study evaluated whether maternal mood disorders, particularly bipolar disorder, and lithium treatment during pregnancy influenced the neonatal health and cognition of children born from 2006- 2010. METHODS: Our study at Karolinska University Hospital, Stockholm, Sweden, focused on women with and without mood disorders and their children. Information on pharmacotherapy, mental health, delivery and neonatal complications was retrospectively collected from electronic patient records...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29150862/randomised-crossover-trial-showed-that-using-breast-milk-or-sucrose-provided-the-same-analgesic-effect-in-preterm-infants-of-at-least-28-weeks
#5
L Collados-Gómez, P Ferrera-Camacho, E Fernandez-Serrano, V Camacho-Vicente, C Flores-Herrero, A M García-Pozo, R Jiménez-García
AIM: Repeated, on-going exposure to pain influences the growth, cognitive and motor functions, behaviour, personality and neurodevelopment of preterm infants. We compared the analgesic effects of expressed breast milk and 24% oral sucrose on preterm neonates during venipuncture. METHODS: This multicentre randomised, non-inferiority, cross-over trial focused on five neonatal university units in Madrid, Spain, from October 2013 to October 2014. It comprised 66 preterm infants born at less than 37 weeks and randomly split into two groups...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29150791/16-channel-flexible-system-to-measure-electrophysiological-properties-of-bioengineered-hearts
#6
Betsy H Salazar, Kristopher A Hoffman, Anilkumar K Reddy, Sridhar Madala, Ravi K Birla
As tissue engineering continues to mature, it is necessary to develop new technologies that bring insight into current paradigms and guide improvements for future experiments. To this end, we have developed a system to characterize our bioartificial heart model and compare them to functional native structures. In the present study, the hearts of adult Sprague-Dawley were decellularized resulting in a natural three-dimensional cardiac scaffold. Neonatal rat primary cardiac cells were then cultured within a complex 3D fibrin gel, forming a 3-dimensional cardiac construct, which was sutured to the acellular scaffold and suspended in media for 24-48 h...
November 17, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29150648/shedding-light-on-the-neonatal-brain-probing-cerebral-hemodynamics-by-diffuse-optical-spectroscopic-methods
#7
Parisa Farzam, Erin M Buckley, Pei-Yi Lin, Katherine Hagan, P Ellen Grant, Terrie Eleanor Inder, Stefan A Carp, Maria Angela Franceschini
Investigating the cerebral physiology of healthy term newborns' brains is important for better understanding perinatal brain injuries, of which the most common etiologies are hypoxia and ischemia. Hence, cerebral blood flow and cerebral oxygenation are important biomarkers of brain health. In this study, we employed a hybrid diffuse optical system consisting of diffuse correlation spectroscopy (DCS) and frequency-domain near infrared spectroscopy (FDNIRS) to measure hemoglobin concentration, oxygen saturation, and indices of cerebral blood flow and metabolism...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150458/diagnostic-accuracy-of-neonatal-assessment-for-gestational-age-determination-a-systematic-review
#8
REVIEW
Anne Cc Lee, Pratik Panchal, Lian Folger, Hilary Whelan, Rachel Whelan, Bernard Rosner, Hannah Blencowe, Joy E Lawn
CONTEXT: An estimated 15 million neonates are born preterm annually. However, in low- and middle-income countries, the dating of pregnancy is frequently unreliable or unknown. OBJECTIVE: To conduct a systematic literature review and meta-analysis to determine the diagnostic accuracy of neonatal assessments to estimate gestational age (GA). DATA SOURCES: PubMed, Embase, Cochrane, Web of Science, POPLINE, and World Health Organization library databases...
November 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/29150457/combination-analgesia-for-neonatal-circumcision-a-randomized-controlled-trial
#9
Rana Sharara-Chami, Zavi Lakissian, Lama Charafeddine, Nadine Milad, Yaser El-Hout
OBJECTIVES: There is no consensus on the most effective pain management for neonatal circumcision. We sought to compare different modalities. METHODS: This is a double-blinded randomized controlled trial comparing 3 combination analgesics used during circumcision (EMLA + sucrose; EMLA + sucrose + dorsal penile nerve block [DPNB]; EMLA + sucrose + ring block [RB]) with the traditional topical analgesic cream EMLA alone. The trial was set in the normal nursery of a teaching hospital...
November 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/29150336/urinary-tract-infections-in-neonates-with-unexplained-pathological-indirect-hyperbilirubinemia-prevalence-and-significance
#10
Elif Bahat Ozdogan, Mehmet Mutlu, Secil Arslansoyu Camlar, Gülcin Bayramoglu, Sebnem Kader, Yakup Aslan
BACKGROUND: It is controversial to test for urinary tract infection (UTI) in patients with unexplained indirect hyperbilirubinemia in the first 2 weeks of life. We aimed to study the prevalence and significance of UTIs in such neonates who were requiring phototherapy. METHODS: Subjects were 2- to 14-day-old neonates with indirect bilirubin levels above phototherapy limit with no other abnormality in their bilirubinaemia-related etiologic workup. UTI was diagnosed by 2 consecutive positive cultures obtained by catheterisation, documenting growth of >10,000 colonies of the same microorganism with consistent antibiograms...
October 28, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29150310/zika-virus-in-french-polynesia-2013-14-anatomy-of-a-completed-outbreak
#11
REVIEW
Didier Musso, Hervé Bossin, Henri Pierre Mallet, Marianne Besnard, Julien Broult, Laure Baudouin, José Eduardo Levi, Ester C Sabino, Frederic Ghawche, Marion C Lanteri, David Baud
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays...
November 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29150292/neonatal-and-regressive-forms-of-autism-diseases-with-similar-symptoms-but-a-different-etiology
#12
William E Barbeau
Autistic Spectrum Disorder (ASD) can be a debilitating, life-long neurocognitive disease. ASD is caused by genetic and epigenetic factors and largely unknown and poorly understood environmental triggers. Signs and symptoms of ASD often appear in the first year of life while the disease strikes other infants who had previously been developing normally at around 2years of age. Ozonoff and her colleagues recently suggested that there are three different pathways or trajectories for the development of ASD in infants 6-24months of age...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29150201/nations-within-a-nation-variations-in-epidemiological-transition-across-the-states-of-india-1990-2016-in-the-global-burden-of-disease-study
#13
(no author information available yet)
BACKGROUND: 18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016...
November 13, 2017: Lancet
https://www.readbyqxmd.com/read/29150122/neonatal-sepsis-secondary-to-chorioamnionitis-by-actinomyces-neuii-in-a-25-weeks-pregnant-woman
#14
Patricia Giron de Velasco-Sada, Helena Peinado, María Pilar Romero-Gómez
No abstract text is available yet for this article.
November 14, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29150056/respiratory-distress-in-the-neonate-case-definition-guidelines-for-data-collection-analysis-and-presentation-of-maternal-immunization-safety-data
#15
Leigh R Sweet, Cheryl Keech, Nicola P Klein, Helen S Marshall, Beckie N Tagbo, David Quine, Pawandeep Kaur, Ilia Tikhonov, Muhammad Imran Nisar, Sonali Kochhar, Flor M Muñoz
No abstract text is available yet for this article.
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29150055/neonatal-encephalopathy-case-definition-guidelines-for-data-collection-analysis-and-presentation-of-maternal-immunisation-safety-data
#16
Erick Sell, Flor M Munoz, Aung Soe, Max Wiznitzer, Paul T Heath, E D Clarke, Hans Spiegel, Daphne Sawlwin, Maja Šubelj, Ilia Tikhonov, Khorshid Mohammad, Sonali Kochhar
No abstract text is available yet for this article.
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29149877/key-bottlenecks-to-the-provision-of-safe-obstetric-anaesthesia-in-low-income-countries-a-cross-sectional-survey-of-64-hospitals-in-uganda
#17
Isabella Epiu, Agnes Wabule, Andrew Kambugu, Harriet Mayanja-Kizza, Jossy Verel Bahe Tindimwebwa, Gerald Dubowitz
BACKGROUND: Despite recent advances in surgery and anaesthesia which significantly improve safety, many health facilities in low-and middle-income countries (LMICs) remain chronically under-resourced with inability to cope effectively with serious obstetric complications (Knight et al., PLoS One 8:e63846, 2013). As a result many of these countries still have unacceptably high maternal and neonatal mortality rates. Recent data at the national referral hospitals in East Africa reported that none of the national referral hospitals met the World Federation of Societies of Anesthesiologists (WFSA) international standards required to provide safe obstetric anaesthesia (Epiu I: Challenges of Anesthesia in Low-and Middle-Income Countries...
November 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29149816/maternal-dyslipidaemia-in-pregnancy-with-gestational-diabetes-mellitus-possible-impact-in-the-foetoplacental-vascular-function-and-the-lipoprotein-in-the-neonatal-circulation
#18
Susana Contreras-Duarte, Lorena Carvajal, Barbara Fuenzalida, Claudette Cantin, Luis Sobrevia, Andrea Leiva
Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing foetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational diabetes mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29149698/ectrodactyly-in-a-chinese-patient-born-to-a-mother-with-neuromyelitis-optica-spectrum-disorder
#19
Yanyu Chang, Yaqing Shu, Xiaobo Sun, Chengfang Xu, Dan He, Ling Fang, Chen Chen, Xueqiang Hu, Allan Kermode, Wei Qiu
NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29149633/neonatal-and-long-term-ophthalmological-findings-in-infants-with-symptomatic-and-asymptomatic-congenital-cytomegalovirus-infection
#20
Maria Grazia Capretti, Concetta Marsico, Simonetta Guidelli Guidi, Antonio Ciardella, Giuliana Simonazzi, Silvia Galletti, Liliana Gabrielli, Tiziana Lazzarotto, Giacomo Faldella
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is responsible of a high burden of neurosensory impairment in children. OBJECTIVES: To report incidence and consequences of ophthalmological abnormalities in infants with cCMV infection and better define their long-term ophthalmological management. STUDY DESIGN: Infants with cCMV infection were enrolled in a 6-year follow-up. Infants were classified as symptomatic or asymptomatic based on complete clinical, laboratory and instrumental evaluations...
November 7, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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