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Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
July 19, 2018: Neonatology
Kasper Jacobsen Kyng, Anders Valdemar Edhager, Tine Brink Henriksen, Christer Zøylner Swan, Niels Gregersen, Johan Palmfeldt
BACKGROUND: Biomarkers may qualify diagnosis, treatment allocation, and prognostication in neonatal encephalopathy. Biomarker development is challenged by competing etiologies, inter-individual genetic variability, and a lack of specific neonatal markers. To address these challenges, we used a standardized neonatal hypoxic-ischemic (HI) encephalopathy model with pre- and post-HI sampling of cerebrospinal fluid (CSF) and plasma. OBJECTIVES: The study aimed to identify novel candidate protein biomarkers of HI encephalopathy in a newborn piglet model in CSF and plasma...
July 19, 2018: Neonatology
Xiaoning Song, Rui Li, Hailiang Deng, Ye Li, Yanan Cui, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang, Qiang Zhang
Active-targeting nanocarriers can significantly improve the transcytosis of poorly water-soluble or bio-macromolecular drugs across biological barrier. However, reasons for the improvement are not understood enough, which hampered the reasonable design of active targeting nanocarriers. To illustrate how different factors influence the transport of active-targeting nanocarriers, we established ligand-decorated micelles targeting different receptors to study how the decorations influence the transcytosis of the micelles by comparing the endocytosis, transport pathway and exocytosis process...
July 5, 2018: Biomaterials
Pierre Kuhn, Jacques Sizun, Charlotte Casper
AIM: Hospitalised newborn infants may be stressed due to inappropriate sensory stimuli and early separation from their families, that can negatively impact their neurodevelopment. The French Group of Reflection and Evaluation of the Environment of Newborns (GREEN) issues guidelines based on environmental neonatology and family centred care. The first recommendation focuses on private family rooms versus large shared rooms. METHODS: These guidelines are based on a systematic evaluation of the literature providing different grades of evidence...
July 19, 2018: Acta Paediatrica
Hirokazu Tsubone, Tatsushi Mutoh
We studied the effect of glucose supply on mitochondrial respiratory function (MRF) of neonatal rat cardiomyocytes, using a novel extracellular flux analysis. Fundamental respiratory parameters regarding oxygen consumption rate in mitochondria showed glucose concentration-dependent changes, where a significant increase or decrease in these parameters was observed to be associated with glucose concentrations ranging between 10% and 1,000% of the concentration used in standard medium (3,151 mg/L), respectively...
July 19, 2018: Clinical and Experimental Pharmacology & Physiology
Miguel M Pinto, Soledad Monges, Edoardo Malfatti, Fabiana Lubieniecki, Xavière Lornage, Laura Alias, Clémence Labasse, Angéline Madelaine, Michel Fardeau, Jocelyn Laporte, Eduardo F Tizzano, Norma B Romero
INTRODUCTION: Mutations in the EXOSC3 gene are responsible for type 1 pontocerebellar hypoplasia, an autosomal recessive congenital disorder characterized by cerebellar atrophy, developmental delay and anterior horn motor neuron degeneration. Muscle biopsies of these patients often show characteristics resembling classic spinal muscle atrophy, but to date no distinct features have been identified. METHODS: Clinical data and muscle biopsy findings of three unrelated patients with EXOSC3 mutations are described...
July 19, 2018: Muscle & Nerve
Alexandra Gogola, Ning-Jiun Jan, Bryn Brazile, Po Lam, Kira L Lathrop, Kevin C Chan, Ian A Sigal
Purpose: Collagen is the main load-bearing component of the eye, and collagen crimp is a critical determinant of tissue mechanical behavior. We test the hypothesis that collagen crimp morphology varies over the human cornea and sclera and with age. Methods: We analyzed 42 axial whole-globe sections from 20 normal eyes of 20 human donors, ranging in age from 0.08 (1 month) to 97 years. The sections were imaged using polarized light microscopy to obtain μm-scale fiber bundle/lamellae orientation from two corneal and six scleral regions...
June 1, 2018: Investigative Ophthalmology & Visual Science
Dietrich Rothenbacher, Stefanie Braig, Chad A Logan, Gertrud Feike, Miriam Müller, Wolfgang Koenig, Frank Reister, Jon Genuneit
PURPOSE: In utero exposure to cardiometabolic risk factors may determine health related outcomes at birth and in later life. The aim of this analysis was to describe the relationship of maternal serum uric acid (SUA) and cystatin C with maternal and neonatal cardiometabolic risk markers and with birth weight and risk of small-for-gestational age (SGA) as well as large-for gestational age (LGA). MATERIAL AND METHODS: In the Ulm SPATZ Health Study, 934 singleton newborns and their mothers were recruited during their hospital stay in the University Medical Center Ulm between 04/2012 and 05/2013 (overall response 49%)...
2018: PloS One
Roberta Rovito, Hans-Jörg Warnatz, Szymon M Kiełbasa, Hailiang Mei, Vyacheslav Amstislavskiy, Ramon Arens, Marie-Laure Yaspo, Hans Lehrach, Aloys C M Kroes, Jelle J Goeman, Ann C T M Vossen
Congenital Cytomegalovirus infection (cCMV) is the leading infection in determining permanent long-term impairments (LTI), and its pathogenesis is largely unknown due to the complex interplay between viral, maternal, placental, and child factors. The cellular activity, considered to be the result of the response to exogenous and endogenous factors, is captured by the determination of gene expression profiles. In this study, we determined whole blood transcriptomes in relation to cCMV, CMV viral load and LTI development at 6 years of age by using RNA isolated from neonatal dried blood spots (DBS) stored at room temperature for 8 years...
2018: PloS One
David E Jones, Kim Hart, Stuart K Shapira, Mary Murray, Robyn Atkinson-Dunn, Andreas Rohrwasser
Newborn screening for primary congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). Untreated congenital hypothyroidism can result in cognitive impairment and growth complications (decreased height/length). Initial newborn screening for congenital hypothyroidism is typically performed 24-48 hours after birth. Fourteen states, including Utah, perform a routine second screen at approximately 2 weeks of age.* During 2010-2016, a total of 359,432 infants in Utah were screened for congenital hypothyroidism, and 130 cases were diagnosed; among these, 98 had an abnormal first screen, and 25 had an abnormal second screen (seven infants were excluded because of missing data)...
July 20, 2018: MMWR. Morbidity and Mortality Weekly Report
Lisa Giardinelli, Lorenzo Lelli, Valentina Ugolini, Lisa Lazzeretti, Iuliia Burian, Giuliana Lino, Clara Lunardi, Giovanni Castellini, Valdo Ricca
Background In this pilot study, the effects of selective serotonin reuptake inhibitors (SSRIs) and psychological intervention on fetal growth characteristics and neonatal outcomes were evaluated in two different groups of women affected by prenatal depression. Methods Forty-seven pregnant women diagnosed with major depression were divided into two different treatment groups according to the severity of their depression. The first group was treated with a combination of pharmacotherapy and psychological support...
July 19, 2018: Journal of Perinatal Medicine
Damian Warzecha, Eliza Kobryń, Marta Bagińska, Dorota Bomba-Opoń
BACKGROUND: Fetal growth restriction (FGR) is an unclearly defined condition described as a fetal weight which is too low in relation to gestational age. It is recognized in 10-15% of singleton pregnancies and can lead to severe complications, including stillbirth. To reduce the adverse fetal and neonatal outcomes, many medical interventions are being introduced by obstetricians. These, like all medical procedures, may induce further complications, such as preterm labor and its consequences...
July 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
P Zhang, T-T Cui, Z-H Zhang, Y-Q Wang
OBJECTIVE: We aimed at studying the effect of adjuvant therapy with low-dose vitamin A on the function of T lymphocytes in neonatal pneumonia. PATIENTS AND METHODS: We recruited 60 cases of neonatal pneumonia which were randomly divided in two equal groups. The control group was treated with conventional anti-inflammatory therapy and aerosol inhalation. The experimental group received oral vitamin A soft capsules for 7 days. RESULTS: Pre-treatment levels vitamin A level and vitamin A deficiency disorders (VADD) percentage revealed no differences between the two groups...
July 2018: European Review for Medical and Pharmacological Sciences
Christoph M Rüegger, Bernhard Frey
OBJECTIVES: To test the hypothesis that patients who die in a PICU despite a low predicted mortality at PICU admission are affected by serious errors and adverse events. DESIGN: Retrospective cross-sectional review of medical records for serious errors and adverse events. SETTING: Tertiary interdisciplinary neonatal PICU. PATIENTS: All admissions to our PICU who died despite a low expected mortality (Pediatric Index of Mortality) of less than 10% (trigger-positive admissions)...
July 17, 2018: Pediatric Critical Care Medicine
Crîngu Antoniu Ionescu, Dan Calin, Dan Navolan, Alexandra Matei, Mihai Dimitriu, Catalin Herghelegiu, Liana Ples
RATIONALE: Holoprosencephaly is a structural malformation of the brain that results from the complete or incomplete noncleavage of the forebrain of the embryo into 2 hemispheres. We report a severe case of alobar holoprosencephaly diagnosed at 38 weeks, associated with cebocephaly, microcephaly, and craniosynostosis. PATIENT CONCERN: The main knowledge added by this case is the late ultrasound diagnosis and chromosomal analysis that revealed a very rare abnormality (45X/46,XX/47,XX) with mosaicism at chromosome 18...
July 2018: Medicine (Baltimore)
Jebrane Bouaoud, Sylvie Fraitag, Veronique Soupre, Marc Mitrofanoff, Olivia Boccara, Christelle Galliot, Christine Bodemer, Arnaud Picard, Roman H Khonsari
BACKGROUND: Fibroblastic connective tissue nevi (FCTN) are benign skin conditions characterized by bland spindle cells infiltrating the reticular dermis and the upper subcutis with preservation of adnexal structures. A subset of FCTN expresses CD34, which may cause difficulties in the differential diagnosis, in particular with dermatofibrosarcoma (DFSP). We aim to study clinical and histological main features of congenital FCTN to better understand their heterogeneity. METHODS: We present 3 cases of congenital FCTN with misleading pseudo-tumoral presentations and compare them with published cases in literature...
July 19, 2018: Pediatric Dermatology
Zongjian Yang, Hai Phung, Louise Freebairn, Rosalind Sexton, Alexandra Raulli, Paul Kelly
AIMS: Maternal overweight and obesity in pregnancy are known to increase the risk of a range of complications and adverse pregnancy outcomes. This study estimates the population-level contribution of maternal overweight and obesity to adverse pregnancy outcomes. METHODS: Data derived from the Australian Capital Territory (ACT) Maternal and Perinatal Data Collection were analysed. A total of 24 161 women who had a singleton birth in 2009-2015, with maternal weight and height information available, were included...
July 19, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Maria Cutumisu, Matthew R G Brown, Caroline Fray, Georg M Schmölzer
This study examines for the first time the moderating role of growth mindset on the association between the time elapsed since participants' last refresher neonatal resuscitation program (NRP) course and their performance on neonatal resuscitation tasks in the RETAIN computer game training simulation. Participants were n = 50 health-care providers affiliated with a large university hospital. Results revealed that growth mindset moderated the relation between participants' task performance in the game and the time since their latest refresher NRP course...
2018: Frontiers in Pediatrics
Abdullah H Baqui, Salahuddin Ahmed, Nazma Begum, Rasheda Khanam, Diwakar Mohan, Meagan Harrison, Ahmed Al Kabir, Catharine McKaig, Neal Brandes, Maureen Norton, Saifuddin Ahmed
Background: Short birth intervals are associated with an increased risk of adverse perinatal outcomes. However, reduction of rates of short birth intervals is challenging in low-resource settings where majority of the women deliver at home with limited access to family planning services immediately after delivery. This study examines the feasibility of integrating a post-partum family planning intervention package within a community-based maternal and newborn health intervention package, and evaluates the impact of integration on reduction of rates of short birth intervals and preterm births...
December 2018: Journal of Global Health
Sarah G Moxon, Tanya Guenther, Sabine Gabrysch, Christabel Enweronu-Laryea, Pavani K Ram, Susan Niermeyer, Kate Kerber, Cally J Tann, Neal Russell, Lily Kak, Patricia Bailey, Sasha Wilson, Wenjuan Wang, Rebecca Winter, Liliana Carvajal-Aguirre, Hannah Blencowe, Oona Campbell, Joy Lawn
Background: Each year an estimated 2.6 million newborns die, mainly from complications of prematurity, neonatal infections, and intrapartum events. Reducing these deaths requires high coverage of good quality care at birth, and inpatient care for small and sick newborns. In low- and middle-income countries, standardised measurement of the readiness of facilities to provide emergency obstetric care has improved tracking of readiness to provide care at birth in recent years. However, the focus has been mainly on obstetric care; service readiness for providing inpatient care of small and sick newborns is still not consistently measured or tracked...
June 2018: Journal of Global Health
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