Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Andrew Lloyd, Kim Rand, Cleo Pike, Crispin Ellis
INTRODUCTION: The Individualized Neuromuscular Quality of Life Questionnaire (INQoL) is used to measure quality of life in neuromuscular disorders such as non-dystrophic myotonia (NDM). Here we report methods to estimate utilities, with a focus on NDM, from this questionnaire based on two preference elicitation exercises. METHODS: Eight items from the INQoL were selected with input from three neuromuscular disorder clinical experts with expertise in treating NDM...
February 28, 2024: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
#22
JOURNAL ARTICLE
Louis S Matza, Katie D Stewart, Marie Fournier, Donna Rowen, Robin Lachmann, Maurizio Scarpa, Eugen Mengel, Travis Obermeyer, Evren Ayik, Fernando Laredo, Ruth Pulikottil-Jacob
INTRODUCTION: Acid sphingomyelinase deficiency (ASMD) type B is a rare genetic disorder leading to enlargement of the spleen and liver, pulmonary dysfunction, and other symptoms. Cost-utility analyses are often conducted to quantify the value of new treatments, and these analyses require health state utilities. Therefore, the purpose of this study was to estimate utilities associated with varying levels of severity of adult and pediatric ASMD type B. METHODS: Seven adult and seven child health state vignettes describing ASMD were developed based on published literature, clinical trial results, and interviews with clinicians, patients with ASMD, and parents of children with ASMD...
February 27, 2024: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
#23
JOURNAL ARTICLE
Rudy S Suidan, Charlotte C Sun, Amy K Schneider, Karen H Lu, Sharon H Giordano, Larissa A Meyer
OBJECTIVE: To assess the health state utilities of ovarian cancer patients, clinicians, and non-cancer controls regarding surgical complications in ovarian cancer. METHODS: Utilities for 14 surgical complications were assessed from patients with recently diagnosed or recurrent ovarian cancer, clinicians, and non-cancer controls using the visual analog scale (VAS) and time trade-off (TTO) methods. Health state utilities were converted to a 0-to-1 scale, where 0 represents the least favorable outcome and 1 represents the most favorable outcome...
February 19, 2024: Gynecologic Oncology
#24
JOURNAL ARTICLE
Xiongwen Yang, Bo Yang, Dan Li, Wei Pan, Qin Tong, Lili Wang, Danjun Chen, Chengxiao Fu
BACKGROUND AND OBJECTIVES: Although thromboembolic events (TEEs) have been reported with the use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), their association remains largely unknown. In this study, we aimed to provide a comprehensive review of TEEs associated with EGFR-TKIs. METHODS: We collected EGFR-TKIs (gefitinib, erlotinib, afatinib, and osimertinib) adverse reaction reports from 2015 Q1 to 2023 Q1 from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database...
February 20, 2024: Clinical Drug Investigation
#25
JOURNAL ARTICLE
Tyler J Uppstrom, Connor F Fletcher, Daniel W Green, Andreas H Gomoll, Sabrina M Strickland
BACKGROUND: Distalization tibial tubercle osteotomy (TTO) is an effective treatment for improving patellar height in patients with patella alta associated with patellofemoral instability and cartilage lesions. The addition of a patellar tendon tenodesis has been suggested; nonetheless, concerns exist regarding possible increased patellofemoral cartilage stresses. PURPOSE: To evaluate pre- and postoperative patellar tendon length and alignment parameters on magnetic resonance imaging (MRI), as well as patient-reported outcome measures (PROMs) after distalization TTO without patellar tendon tenodesis...
February 2024: Orthopaedic Journal of Sports Medicine
#26
JOURNAL ARTICLE
Ralph H B Benedict, Pamela Vo, Nicholas Adlard, Olwyn Grennan, Ashley Enstone, Daisy Bridge, Robin Wyn, Stanley L Cohan
INTRODUCTION: Cognitive impairment, especially relating to cognitive processing speed, is a major cause of disability in people with multiple sclerosis (MS). Utility values are quantitative estimates of the quality of life experienced in specific health states and are a key component of cost-effectiveness modelling. However, existing health state utility values in MS typically focus on physical ability and are generally derived using generic (not disease-specific) measures of quality of life...
2024: ClinicoEconomics and Outcomes Research: CEOR
#27
JOURNAL ARTICLE
Takeru Shiroiwa, Tatsunori Murata, Yasuhiro Morii, Eri Hoshino, Takashi Fukuda
BACKGROUND: AP-7D is a newly developed preference-based measure (PBM) in East and Southeast Asia. However, no value set has been established yet. Comparison of the characteristics of value sets obtained by different methods is necessary to consider the most appropriate methodology for valuation survey of AP-7D. METHOD: We surveyed the general population's preference of AP-7D health states by four valuation methods (a) composite time trade-off (cTTO); (b) simple discrete choice experiment (DCE); (c) DCE with duration; and (d) ternary DCE...
February 10, 2024: Health and Quality of Life Outcomes
#28
JOURNAL ARTICLE
Robin Jeanna Vermeulen, Bram Roudijk, Tim Martin Govers, Maroeska Mariet Rovers, Marcel Gerardus Maria Olde Rikkert, Ben Franciscus Martinus Wijnen
BACKGROUND: The increasing interest in early identification of people at risk of developing dementia, has led to the development of numerous models aimed at estimating the likelihood of progression from mild cognitive impairment (MCI) to dementia. It is important to study both the need for and possible outcomes related with such prediction models, including the impact of risk predictions on perceived quality of life (QoL). OBJECTIVE: This study aimed to quantify the impact that receiving a risk prediction on progression from MCI to dementia has on QoL...
February 3, 2024: Journal of Alzheimer's Disease: JAD
#29
JOURNAL ARTICLE
Wei Yang, Yuxi Gong, Yansong Wang, Chao Wu, Xiangyu Zhang, Jinlian Li, Dongmei Wu
Microencapsulation has been widely used to protect essential oils, facilitating their application in cosmetics. In this study, gelatin, gum arabic and n -butyl cyanoacrylate were used as wall materials, and composite microcapsules of tea tree essential oil (TTO) were prepared using a combination of composite coagulation and in situ polymerization methods. When the ratio of gelatin to gum arabic is 1 : 1, the ratio of TTO to n -butyl cyanoacrylate is 4 : 1, the curing time is 10 h, and the encapsulation efficiency (EE) under these conditions is 73...
January 31, 2024: RSC Advances
#30
JOURNAL ARTICLE
Lea Bentz, Diego Olaya Mantilla, Sibylle M Winter
Compared to sexual and physical violence, cases of emotional abuse are often more difficult to detect. An increasingly advocated approach involves regular assessments within social and healthcare structures tto proactively identify affected children and adolescents at an early stage. This enables the prompt initiation of appropriate interventions. Following, interdisciplinary institutions such as a child protection outpatient clinic can play an important role for professionals in the clarification of suspected child endangerment...
January 2024: Praxis der Kinderpsychologie und Kinderpsychiatrie
#31
JOURNAL ARTICLE
Zachary I Li, Sharif Garra, Jordan Eskenazi, Samuel R Montgomery, Jairo Triana, Andrew J Hughes, Michael J Alaia, Eric J Strauss, Laith M Jazrawi, Kirk A Campbell
PURPOSE: To investigate the rate of return to sports and sport psychological readiness between patients who underwent isolated MPFLR (iMPFLR) compared to a matched cohort of patients who underwent MPFLR with anteromedializing tibial tubercle osteotomy (MPFLR/TTO). METHODS: Patients who underwent primary MPFLR with or without TTO for recurrent patellar instability were retrospectively reviewed from 2012 to 2020 at a single institution. Preinjury sport and work information, Kujala, Tegner, Visual Analogue Score for pain, satisfaction and MPFL-Return to Sport after Injury (MPFL-RSI) score were collected...
February 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#32
JOURNAL ARTICLE
Donwoo Lee, Seungjae Lee, Sudeok Shon
Since the mention of the Fourth Industrial Revolution in 2016, quantum computers and quantum computing (QC) have emerged as key technologies. Many researchers are trying to realize quantum computers and quantum computing. In particular, most of the development and application of metaheuristics algorithms using quantum computing is focused on computer engineering fields. Cases in which the developed algorithm is applied to the optimal design of a building or the optimal design results presented by expanding the algorithm in various directions are very insufficient...
December 27, 2023: Biomimetics
#33
JOURNAL ARTICLE
Mariana Alves Battisti, Larissa Constantino, Débora Fretes Argenta, Flávio Henrique Reginatto, Felipe Dal Pizzol, Thiago Caon, Angela Machado Campos
Sepsis represents a complex clinical syndrome that results from a harmful host response to infection. The infections most associated with sepsis are pneumonia, intra-abdominal infection, and urinary tract infection. Tea tree oil (TTO) has shown high antibacterial activity; however, it exhibits low aqueous solubility and high volatility, which have motivated its nanoencapsulation. In this study, the performance of nanoemulsions (NE) and nanocapsules (NC) loaded with TTO was compared. These systems were prepared by spontaneous emulsification and nanoprecipitation methods, respectively...
January 16, 2024: Drug Delivery and Translational Research
#34
EDITORIAL
Seth Lawrence Sherman, Anna Bartsch
When planning an adolescent's primary surgery for recurrent patella instability, the surgeon must weigh the failure risk of performing medial patellofemoral reconstruction (MPFLR) versus the potential morbidity of adding a concomitant bony procedure, such as tibial tubercle osteotomy (TTO). In this age group, isolated MPFLR is an excellent operation with high clinical success, low failure rates, and favorable complication profile. Patients with high grade J-sign and severe trochlea dysplasia, apprehension into deep flexion, and extremes of bony malalignment, including elevated tibial tubercle-trochlear groove distance may benefit from "doing more" than MPFLR alone...
November 19, 2023: Arthroscopy
#35
JOURNAL ARTICLE
Takeru Shiroiwa, Takashi Fukuda
BACKGROUND: Valuation surveys of preference-based measures are typically conducted face-to-face or on web panels. In this survey, we considered whether face-to-face and online surveys were reliable using three tasks: composite time trade-off (cTTO), discrete choice experiment (DCE), and DCE with duration. METHODS: Respondents (aged 20-69 years) for both face-to-face (N = 1000, target sample size) and web surveys were selected through quota sampling by sex and age from each panel of the general population in Japan...
January 13, 2024: Applied Health Economics and Health Policy
#36
JOURNAL ARTICLE
Tomos Robinson, Sarah Hill, Giovany Orozco-Leal, Ashleigh Kernohan, William King, Yemi Oluboyede
PURPOSE: The Weight-Specific Adolescent Instrument for Economic Evaluation (WAItE) is a physical weight-specific patient reported outcome measure for use in adolescence. The purpose of this study was to use the Time Trade-Off (TTO) methodology, administered using an online interviewer-assisted remote survey, to obtain utility values for several health states from the WAItE descriptive system from a sample of the UK adult general population. METHODS: The adult sample was gathered using a market research company and a sample of local residents...
January 12, 2024: Journal of Patient-Reported Outcomes
#37
JOURNAL ARTICLE
Lucas Moreno, Rebekah Weston, Cormac Owens, Dominique Valteau-Couanet, Marion Gambart, Victoria Castel, C Michel Zwaan, Karsten Nysom, Nicolas Gerber, Aurora Castellano, Genevieve Laureys, Ruth Ladenstein, Jochen Rössler, Guy Makin, Dermot Murphy, Bruce Morland, Sucheta Vaidya, Estelle Thebaud, Natasha van Eijkelenburg, Deborah A Tweddle, Giuseppe Barone, Julie Tandonnet, Nadege Corradini, Pascal Chastagner, Catherine Paillard, Francisco J Bautista, Soledad Gallego Melcon, Bram De Wilde, Lynley Marshall, Juliet Gray, Susan A Burchill, Gudrun Schleiermacher, Louis Chesler, Andrew Peet, Martin O Leach, Kieran McHugh, Roisin Hayes, Neil Jerome, Hubert Caron, Jennifer Laidler, Nicola Fenwick, Grace Holt, Veronica Moroz, Pamela Kearns, Simon Gates, Andrew D J Pearson, Keith Wheatley
PURPOSE: Outcomes for children with relapsed and refractory high-risk neuroblastoma (RR-HRNB) remain dismal. The BEACON Neuroblastoma trial (EudraCT 2012-000072-42) evaluated three backbone chemotherapy regimens and the addition of the antiangiogenic agent bevacizumab (B). MATERIALS AND METHODS: Patients age 1-21 years with RR-HRNB with adequate organ function and performance status were randomly assigned in a 3 × 2 factorial design to temozolomide (T), irinotecan-temozolomide (IT), or topotecan-temozolomide (TTo) with or without B...
January 8, 2024: Journal of Clinical Oncology
#38
JOURNAL ARTICLE
M Liu, H Jin, Q Hu, N Chen, Y Zhang, Y Wang
OBJECTIVE: TTo investigate the targeted regulation of the Nrf2 pathway by miR-23b-5p in transdifferentiation of rat renal tubular epithelial NRK-52E cells induced by transforming growth factor β1(TGF-β1)and the effect of Qingshen Granulesmedicated serum for alleviating transdifferentiation of NRK-52E cells. METHODS: NRK-52E cells with TGF-β1-induced transdifferentiation were transfected with miR-23b-5p mimic, miR-23b-5p inhibitor or the negative control(NC)siRNA and then treated with of Qingshen Granules-medicated serum...
December 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
#39
JOURNAL ARTICLE
Soo-Kyoung Kim, Min Kyung Chu, Byung-Kun Kim, Pil-Wook Chung, Heui-Soo Moon, Mi Ji Lee, Yun-Ju Choi, Jeong Wook Park, Byung-Su Kim, Tae-Jin Song, Kyungmi Oh, Jin-Young Ahn, Jong-Hee Sohn, Kwang-Soo Lee, Kwang-Yeol Park, Jae Myun Chung, Chin-Sang Chung, Soo-Jin Cho
BACKGROUND AND PURPOSE: Patients with cluster headache (CH) exhibit impaired health-related quality of life (HRQoL). However, there have been few studies related to the HRQoL of patients with CH from Asian backgrounds. This study aimed to determine the impact of CH on HRQoL and to identify the factors affecting HRQoL in patients with CH during cluster periods. METHODS: This prospective study enrolled patients with CH from 17 headache clinics in South Korea between September 2016 and February 2021...
January 2024: Journal of Clinical Neurology
#40
JOURNAL ARTICLE
Leticia Tinoco Gonçalves, Débora Tacon da Costa, Wender do Nascimento Rouver, Roger Lyrio Dos Santos
AIMS: To evaluate the effects of testosterone on endothelium-dependent vasodilation and oxidative stress in mesenteric resistance arteries. MAIN METHODS: Spontaneously hypertensive rats (SHR), aged 8 to 10 weeks, were divided into four groups: intact (SHAM), intact treated with testosterone (TTO; 3 mg/kg/day) via subcutaneous route (s.c.), intact treated with testosterone and anastrozole [aromatase enzyme inhibitor (TTO + ANA; 0.1 mg/kg/day, s...
January 2, 2024: Life Sciences
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
