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M Chandran, D Tay, X F Huang, Y Hao
Hospital care and mortality of diabetic and non-diabetic osteoporotic Asian patients undergoing hip fracture surgery were explored with no difference in length of hospitalization, incidence of post-operative complications, or mortality between diabetics and non-diabetics seen. Time to operation correlated with post-operative complications occurrence and therefore surgery should be expeditiously done. INTRODUCTION: Whether burden of inpatient care, problems after admission, and mortality rates differ between diabetics and non-diabetics undergoing surgery for osteoporotic hip fractures has not been explored in Asian populations...
March 15, 2018: Archives of Osteoporosis
Liu Liu, Shunping Li, Yue Zhao, Jianglin Zhang, Gang Chen
PURPOSE: To investigate the validity of direct and indirect health state utility (HSU) and subjective well-being measures in psoriasis vulgaris patients. METHODS: A convenience sampling framework was used to successively recruit patients with psoriasis vulgaris from the outpatient clinics of a tertiary hospital in Changsha, Central South China. Participants completed time trade-off (TTO), standard gamble (SG), the five-level EQ-5D (EQ-5D-5L), the WHO-5 well-being index, and the psoriasis disability index (PDI)...
February 28, 2018: Quality of Life Research
M F Janssen, A Szende, J Cabases, J M Ramos-Goñi, G Vilagut, H H König
This study provides EQ-5D population norms for 20 countries (N = 163,838), which can be used to compare profiles for patients with specific conditions with data for the average person in the general population in a similar age and/or gender group. Descriptive EQ-5D data are provided for the total population, by gender and by seven age groups. Provided index values are based on European VAS for all countries, based on TTO for 11 countries and based on VAS for 10 countries. Important differences exist in EQ-5D reported health status across countries after standardizing for population structure...
February 14, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Javier Brazo-Sayavera, Inés M Parejo-Cabezas, Narcís Gusi, Pedro R Olivares
Objetivo: Comparar la percepción de la calidad de vida relacionada con la salud (CVRS) de padres y médico con respecto al paciente en población infantil sometida a una intervención quirúrgica menor, y analizar la progresión de la CVRS tras un mes de someterse a la intervención. Método: Participaron 36 pacientes sometidos a intervenciones quirúrgicas menores. Se les administró el cuestionario EQ-5D-Y, y su versión proxy correspondiente a los padres y al médico...
2018: Gaceta Médica de México
Wenwen Xue, Xian Xu, Haidong Zou
PURPOSE: To determine which utility value assessment method is more suitable to evaluate changes in the quality of life due to dry eye symptoms. METHODS: Dry eye outpatients with a presenting visual acuity of 20/25 or better in the worse-seeing eye were recruited. Presenting distance visual acuity, tear film break-up time, Schirmer I test and fluorescein were assessed. The severity of dry eye symptoms was assessed using the Ocular Surface Disease Index (OSDI), and utility values were measured using the time trade-off (TTO), standard gamble (SG1 and SG2) and rating scale (RS) methods...
February 7, 2018: International Ophthalmology
Wenwen Xue, Ming-Ming Zhu, Bi-Jun Zhu, Jian-Nan Huang, Qian Sun, Yu-Yu Miao, Hai-Dong Zou
PURPOSE: To observe the long-term changes in dry eye symptoms and vision-related quality of life in age-related cataract patients after phacoemulsification. METHODS: A total of 101 cataract patients after phacoemulsification combined with IOL implantation (Ph-IOL) in one eye were enrolled. Visual acuity, tear film breakup time (BUT), and Schirmer test 1 (ST1) were measured before and 1, 3, and 6 months after surgery. Ocular Surface Disease Index (OSDI) scores were used to evaluate the severity of dry eye symptoms...
February 1, 2018: International Ophthalmology
Jinghua Wu, Lei Zhang, Xing Xin, Yang Zhang, Hui Wang, Aihua Sun, Yuchuan Cheng, Xinde Chen, Gaojie Xu
Electrorheological (ER) fluids are denoted as a type of smart fluids because their rheological characteristics can be altered through an electric field. The discovery of giant ER effect revived the researchers' interest in the ER technological area. However, the poor stability including the insufficient dynamic shear stress, large leakage current density as well as the sedimentation tendency still hinder its practical applications. Herein, we report a facile and scalable co-precipitation method for synthesizing surfactant-free tin titanyl oxalate (TTO) particles with tremella-like wrinkly microstructure (W-TTO)...
February 1, 2018: ACS Applied Materials & Interfaces
Stefano Divano, Andrea Camera, Stefano Biggi, Stefano Tornago, Matteo Formica, Lamberto Felli
INTRODUCTION: Tibial tubercle osteotomy (TTO) is a well-established extensile approach to improve joint visualization and implant removal. Despite this, TTO is a challenging technique with a long learning curve and potential pitfalls. Complications are not infrequent, even if performing the correct surgical steps. Aim of this paper is to review the current literature about TTO, its safeness and reliability, and finally the complications rate. MATERIALS AND METHODS: We performed a systematic review of the available English literature, considering the outcomes and the complications of TTO...
January 23, 2018: Archives of Orthopaedic and Trauma Surgery
M D Baldissera, C F Souza, P H Doleski, R C V Santos, R P Raffin, B Baldisserotto
Nanoencapsulated Melaleuca alternifolia essential oil (tea tree oil, TTO) is a natural alternative treatment, with 100% therapeutic efficacy in fish experimentally infected with Pseudomonas aeruginosa, and has also potent protective effects linked with antioxidant properties. However, the pathways responsible for the antioxidant capacity remain unknown. Thus, this study evaluated whether the inhibition of seric xanthine oxidase (XO) activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P...
January 19, 2018: Journal of Fish Diseases
Riaan Botes, Karin M Vermeulen, Adelita V Ranchor, Erik Buskens
BACKGROUND: Assessing quality of life among the elderly is a complex and multifaceted issue. Elderly people might find valuing and describing their personal experience of quality of life (QoL) demanding and cumbersome. This study therefore sought to determine the feasibility of administering two questionnaires in two samples of elderly people. METHODS: A preference-based instrument (EQ-5D + C) and a currently achieved functioning questionnaire (CAF) were utilized...
January 16, 2018: BMC Geriatrics
Janine Verstraete, Lebogang Ramma, Jennifer Jelsma
BACKGROUND: In estimating the impact of an intervention, ignoring the effect of improving the health of one member of the caregiver/child dyad on the Health Related Quality of Life (HRQoL) of the other member may lead to an underestimation of the utility gained. This may be particularly true for infants/young children and their caregivers. The aim of this study was to quantify the interaction between the child's perceived general health as assessed by the newly developed Toddler and Infant Questionnaire (TANDI) on the reporting of the caregiver's own HRQoL as assessed by the EQ-5D-3 L...
January 10, 2018: Health and Quality of Life Outcomes
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown better antithrombotic protection than aspirin and clopidogrel with minimal bleeding tendency in mice. The present study is aimed to systematically investigate the antithrombotic efficacy of S007-867 in comparison to aspirin and clopidogrel in vivo and to delineate its mechanism of action in vitro...
January 5, 2018: Biochemical Pharmacology
Bryan M Saltzman, Allison Rao, Brandon J Erickson, Gregory L Cvetanovich, David Levy, Bernard R Bach, Brian J Cole
Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched the literature for tibial tubercle osteotomy (TTO) studies and systematically reviewed them for indications, clinical outcomes, complications, and reoperations. Therapeutic clinical studies that reported TTO indications, operative findings, and outcomes were included. Quality of each study was assessed with the modified Coleman methodology score (MCMS). Twenty-one studies (976 patients, 1055 knees) were included in the analysis...
November 2017: American Journal of Orthopedics
Kristian Svendsen, Mollie Wood, Erika Olsson, Hedvig Nordeng
PURPOSE: Despite FDA and EMA warnings of long-term use, little is known regarding the time to onset (TTO) of neurological adverse drug reactions (ADR) for metoclopramide. The aims of this study were, first, to evaluate whether neurological ADRs are more commonly reported for metoclopramide than for other medications, and second, to describe how time to onset of neurological ADRs differs by age and gender. METHODS: All ADR reports with metoclopramide as the suspected/interacting drug were extracted from the WHOs Global ADR database Vigibase® between 1967 and May 2016...
December 30, 2017: European Journal of Clinical Pharmacology
Seongcheol Kim, Abdullah Alsrhani, Lala Zafreen, Gauri Khandekar, Florence L Marlow, Elliott W Abrams, Mary C Mullins, Pudur Jagadeeswaran
Haemostasis is a defence mechanism that has evolved to protect organisms from losing their circulating fluid. We have previously introduced zebrafish as a model to study the genetics of haemostasis to identify novel genes that play a role in haemostasis. Here, we identify a zebrafish mutant that showed prolonged time to occlusion (TTO) in the laser injury venous thrombosis assay. By linkage analysis and fine mapping, we found a mutation in the orphan G protein-coupled receptor 34 like gene (gpr34l) causing a change of Val to Glu in the third external loop of Gpr34l...
December 21, 2017: British Journal of Haematology
F E van Nooten, K Houghton, J van Exel, M van Agthoven, W B F Brouwer, D E Stull
BACKGROUND: Conflicting results regarding associations of time trade-off (TTO) valuations with respondent characteristics have been reported, mostly on the basis of regression analyses. Alternative approaches, such as the latent class analysis (LCA), may add to the further understanding of variations in TTO responses. OBJECTIVES: To identify whether subgroups of respondents can be identified on the basis of their responses to TTO exercises and to investigate which respondent characteristics are associated with membership of the identified subgroups...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
L M Peña-Longobardo, B Rodríguez-Sánchez, M Mata-Cases, L Rodríguez-Mañas, M Capel, J Oliva-Moreno
BACKGROUND: To analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community. METHODS: We used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011-2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases...
2017: PloS One
Axel Svedbom, Fredrik Borgström, Emma Hernlund, Oskar Ström, Vidmantas Alekna, Maria Luisa Bianchi, Patricia Clark, Manuel Díaz Curiel, Hans Peter Dimai, Mikk Jürisson, Anneli Uusküla, Margus Lember, Riina Kallikorm, Olga Lesnyak, Eugene McCloskey, Olga Ershova, Kerrie M Sanders, Stuart Silverman, Marija Tamulaitiene, Thierry Thomas, Anna N A Tosteson, Bengt Jönsson, John A Kanis
INTRODUCTION: The International Costs and Utilities Related to Osteoporotic fractures Study is a multinational observational study set up to describe the costs and quality of life (QoL) consequences of fragility fracture. This paper aims to estimate and compare QoL after hip, vertebral, and distal forearm fracture using time-trade-off (TTO), the EuroQol (EQ) Visual Analogue Scale (EQ-VAS), and the EQ-5D-3L valued using the hypothetical UK value set. METHODS: Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall), and at 4, 12, and 18 months after fracture...
March 2018: Quality of Life Research
Joseph N Liu, Hao-Hua Wu, Grant H Garcia, Irene L Kalbian, Sabrina M Strickland, Beth E Shubin Stein
PURPOSE: To determine the rate of return to sports and clinical outcomes after anteromedialization (AMZ) tibial tubercle osteotomy (TTO) for patients with patellofemoral pain and/or osteoarthritis. METHODS: This study is a retrospective case series of consecutive patients who underwent unilateral or staged bilateral AMZ TTO for a primary diagnosis of patellofemoral pain or arthritis. Included were all patients with minimum 1-year follow-up. The indication for surgery was failure of at least 6 months of nonoperative treatment...
December 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharazi, Samira Rasoulikoohi, Amir Amani
Highly resistant pathogens may be developed in patients with immune disorders after prolonged exposure to antibiotics, a growing threat worldwide. In order to overcome these problems, this study introduces a new class of engineered nanosystems comprising of tea tree oil nanoemulsion (TTO NE) loaded with Ag nanoparticles (NPs). Silver shows a strong toxicity towards a wide range of microorganisms. Also, TTO NE could be employed as a promising and safe antimicrobial agent for local therapies of bacterial infections...
December 7, 2017: AAPS PharmSciTech
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