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https://www.readbyqxmd.com/read/28292493/patient-preferences-for-minimally-invasive-and-open-locoregional-treatment-for-early-stage-breast-cancer
#1
Floortje M Knuttel, Maurice A A J van den Bosch, Danny A Young-Afat, Marleen J Emaus, Desirée H J G van den Bongard, Arjen J Witkamp, Helena M Verkooijen
BACKGROUND: Noninvasive or minimally invasive treatments are being developed as alternatives to surgery for patients with early-stage breast cancer. Patients' preferences with regard to these new treatments have not been investigated. OBJECTIVES: To assess preferences of patients with breast cancer and of healthy women regarding these new techniques, compared with conventional surgical treatments. METHODS: Six hypothetical breast cancer treatment-outcome scenarios were developed: three standard surgical scenarios (mastectomy, mastectomy with immediate implant-based reconstruction, and breast-conserving therapy [BCT]) and three minimally invasive or noninvasive scenarios (radiofrequency ablation, magnetic resonance-guided high-intensity focused ultrasound ablation, and single-dose ablative radiotherapy)...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28280905/clinical-outcomes-after-revision-surgery-for-medial-patellofemoral-ligament-reconstruction
#2
Andreas Chatterton, Torsten Grønbech Nielsen, Ole Gade Sørensen, Martin Lind
PURPOSE: Medial patellofemoral ligament reconstruction (MPFL-R) is the standard surgical intervention for patella instability. However, limited knowledge exists concerning the causes for failure, and outcome after revision MPFL-R. The purpose of this study is to evaluate the causes of primary MPFL-R failure and clinical outcomes after revision MPFL-R. METHODS: Twenty-three patients (6 males and 17 females) with failed primary MPFL-R underwent isolated revision MPFL-R or combined revision MPFL-R with tibial tuberosity osteotomy (TTO)...
March 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28259148/establishing-disability-weights-for-congenital-pediatric-surgical-conditions-a-multi-modal-approach
#3
D Poenaru, J Pemberton, C Frankfurter, B H Cameron, E Stolk
BACKGROUND: Burden of disease (BoD) as measured by Disability-Adjusted Life Years (DALYs) is one of the criteria for priority-setting in health care resource allocation. DALYs incorporate disability weights (DWs), which are currently expert-derived estimates or non-existent for most pediatric surgical conditions. The objective of this study is to establish DWs for a subset of key pediatric congenital anomalies using a range of health valuation metrics with caregivers in both high- and low-resource settings...
March 4, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28235118/rates-of-deep-vein-thrombosis-occurring-after-osteotomy-about-the-knee
#4
Brandon J Erickson, Annie Tilton, Rachel M Frank, William Park, Brian J Cole
We conducted a study to determine the rates of symptomatic deep vein thrombosis (DVT) and pulmonary embolism (PE) after high tibial osteotomy (HTO), distal femoral osteotomy (DFO), or tibial tubercle osteotomy (TTO) in patients who did not receive postoperative chemical prophylaxis. All patients who had HTO, DFO, or TTO performed by a single surgeon between 2009 and 2014 were identified. Charts were reviewed to determine presence or absence of DVT or PE. Patient age, smoking status, oral contraceptive (OC) use, and body mass index (BMI) were recorded...
January 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28219389/valuation-of-the-eq-5d-5l-with-composite-time-trade-off-for-the-german-population-an-exploratory-study
#5
Kristina Ludwig, J-Matthias Graf von der Schulenburg, Wolfgang Greiner
BACKGROUND: The EuroQol Group has extended the severity levels of the EQ-5D from three to five (EQ-5D-5L). There are valuation studies worldwide planned in order to convert the EQ-5D-5L health states into a single preference-based summary score based on country-specific value sets of social health status preference valuations. The EuroQol Group developed an internationally standardised EQ-5D-5L valuation protocol. Based on the experiences of the first wave of valuation studies applying the protocol, a number of modifications to the implementation of composite time trade-off (cTTO) were proposed and tested in an exploratory study in Germany...
February 20, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28199035/utility-approach-to-decision-making-in-extended-t1-and-limited-t2-glottic-carcinoma
#6
Yda van Loon, Anne M Stiggelbout, Marieke M Hakkesteegt, Ton P M Langeveld, Rob J Baatenburg de Jong, Elisabeth V Sjögren
BACKGROUND: It is still undecided if endoscopic laser surgery or radiotherapy is the preferable treatment in extended T1 and limited T2 glottic tumors. Health utilities assessed from patients can aid in decision-making. METHODS: Patients treated for extended T1 or limited T2 glottic carcinoma by laser surgery (n = 12) or radiotherapy (n = 14) assigned health utilities using a visual analog scale (VAS), time tradeoff (TTO) technique and scored their voice handicap using the Voice Handicap Index (VHI)...
February 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/28177805/effects-and-possible-mechanism-of-tea-tree-oil-against-botrytis-cinerea-and-penicillium-expansum-in-vitro-and-in-vivo-test
#7
Yonghua Li, Xingfeng Shao, Jiayu Xu, Yingying Wei, Feng Xu, Hongfei Wang
The purpose of this study was to investigate the antifungal activities and possible mechanisms of tea tree oil (TTO) against Botrytis cinerea and Penicillium expansum in vitro and in vivo. The results show that TTO exhibits dose-dependent antifungal activity against both pathogens, but P. expansum is less sensitive than B. cinerea to TTO not only in the in vitro test but also in artificially inoculated cherry fruits. TTO vapor treatment reduced the decay caused by these pathogens in inoculated cherry fruits, but the effect on P...
October 25, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28156653/time-trade-offs-in-advanced-ovarian-cancer
#8
Dana B Mukamel, David E Cohn, Laura Havrilesky, Alexi A Wright, Joseph Lipscomb, Lisa Sparks, Heather Ladd, Kathryn Osann
20 Background: Most women with advanced ovarian cancer develop recurrence and die within five years of diagnosis. This creates a clinical imperative to discuss tradeoffs between the risks and benefits of treatment options. The purpose of this study is to examine the experience of ovarian cancer patients presented with a decision aid leading them through a time-tradeoff (TTO) exercise to guide choice of therapy. METHODS: Newly diagnosed advanced ovarian cancer patients (N = 64) participated in a study evaluating the effectiveness and usefulness of a Patient-Centered Outcome Aid (PCOA)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28089949/melaleuca-alternifolia-nanoparticles-against-candida-species-biofilms
#9
M E Souza, L Q S Lopes, P C Bonez, A Gündel, D S T Martinez, M R Sagrillo, J L Giongo, R A Vaucher, R P Raffin, A A Boligon, R C V Santos
Candida infection is an important cause of morbidity and mortality on immunosuppressed patients. This growing trend has been associated with resistance to the antimicrobial therapy and the ability of microorganism to form biofilms. TTO oil is used as antimicrobial which shows antibiofilm activity against Candida species. However, it presents problems due to its poor solubility and high volatility. The present study aimed to evaluate in vitro antibiofilm activity of TTO nanoparticles against many Candida species...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28074424/signal-detection-based-on-time-to-onset-algorithm-in-spontaneous-reporting-system-of-china
#10
Tianyi Zhang, Xiaofei Ye, Xiaojing Guo, Guizhi Wu, Yongfang Hou, Jinfang Xu, Wentao Shi, Tiantian Zhu, Yuan Zhang, Xinji Zhang, Jiaqi Song, Jia He
INTRODUCTION: The method of time-to-onset (TTO) has been proposed to overcome the drawbacks of traditional disproportionality analyses (DPAs), and it has been used for detecting safety signals of vaccines and some non-vaccine products in spontaneous reporting systems (SRSs). However, there is no consensus on its superiority over DPAs. Further, it is still not clear whether this novel approach can be generalized to the entire national SRS database. OBJECTIVE: The purpose of this study was to generalize the TTO method to the Chinese SRS and to identify suitable parameters for its optimal performance...
January 10, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28065959/clinical-profile-of-patients-with-biopsy-proven-lupus-nephritis-at-a-tertiary-care-hospital-from-northern-pakistan-1995-to-2012
#11
Akhtar Ali, Anjum Mehmood, Muhammad Usman Ali
OBJECTIVE: TTo highlight the clinical spectrum of biopsy-proven lupus nephritis by analysing any variations in its histological subtypes across gender, varying age groups, serum creatinine levels and anti-double stranded deoxyribonucleic acid levels. METHODS: This retrospective, observational study was conducted at the Lady Reading Hospital in collaboration with the Fauji Foundation Hospital, Peshawar, Pakistan, and comprised patient records of biopsy-proven lupus nephritis from 1995 to 2012...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28039941/time-to-onset-of-bisphosphonate-related-osteonecrosis-of-the-jaws-a-multicentre-retrospective-cohort-study
#12
Ppl Fung, G Bedogni, A Bedogni, A Petrie, S Porter, G Campisi, J Bagan, V Fusco, G Saia, S Acham, P Musto, M T Petrucci, P Diz, G Colella, M D Mignogna, M Pentenero, P Arduino, G Lodi, C Maiorana, M Manfredi, P Hallberg, M Wadelius, K Takaoka, Y Y Leung, R Bonacina, M Schiødt, P Lakatos, T Taylor, G De Riu, G Favini, S N Rogers, M Pirmohamed, P Nicoletti, S Fedele
OBJECTIVES: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. SUBJECTS AND METHODS: Retrospective analysis of data from 22 secondary care centres in 7 countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012...
December 31, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28028569/functional-testing-and-return-to-sport-following-stabilization-surgery-for-recurrent-lateral-patellar-instability-in-competitive-athletes
#13
Aaron J Krych, Michael P O'Malley, Nick R Johnson, Rohith Mohan, Timothy E Hewett, Michael J Stuart, Diane L Dahm
PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction and tibial tubercle osteotomy are commonly used to treat recurrent lateral patellar instability, yet there are limited available data on return to sport (RTS) following these procedures. The purpose of this study is to evaluate patient factors associated with excellent functional outcomes, including successful RTS, following surgical stabilization including MPFL reconstruction in competitive athletes with recurrent lateral patellar instability...
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28013459/molecular-and-structural-changes-induced-by-essential-oil-treatments-in-vicia-faba-roots-detected-by-ftir-and-ftnir-spectroscopy
#14
Mauro Mecozzi, Elena Sturchio, Priscilla Boccia, Miriam Zanellato, Claudia Meconi, Francesco Peleggi
Essential oils have recognized antimicrobial and antifungal properties which allow their utilization in agriculture like an alternative to pesticides, but their utilization requires the knowledge of all the potential structural changes and damages produced by the interaction with the vegetal organisms. In this paper, we investigated the effects of two essential oils, the tea tree oil (TTO) and the mixture of clove and rosemary oils (C + R), on the molecular structure of Vicia faba roots by Fourier transform infrared (FTIR) and Fourier near infrared transform (FTNIR) spectroscopy...
December 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27999505/osteochondral-allograft-transplantation-for-femoral-trochlear-dysplasia
#15
Dharmpal V Vansadia, James R Heltsley, Scott Montgomery, Misty Suri, Deryk G Jones
BACKGROUND: The risk factors for patellofemoral joint instability include laxity of medial patellar restraints, abnormal limb geometry, femoral and tibial malrotation, patella alta, and trochlear dysplasia. Femoral trochlear dysplasia is characterized by a hypoplastic or shallow trochlear groove. CASE REPORT: We report the case of a 31-year-old female with trochlear dysplasia and recurrent patella dislocations, laxity of the medial patellofemoral ligament (MPFL), and high-grade chondromalacia of the trochlea and the patella...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27988310/melaleuca-alternifolia-essential-oil-enhances-the-non-specific-immune-system-and-prevents-oxidative-damage-in-rhamdia-quelen-experimentally-infected-by-aeromonas-hydrophila-effects-on-cholinergic-and-purinergic-systems-in-liver-tissue
#16
Matheus D Baldissera, Carine F Souza, Guerino B Júnior, Agueda C de Vargas, Aline A Boligon, Marli M A de Campos, Lenita M Stefani, Bernardo Baldisserotto
The aim of this study was to evaluate the effects of M. alternifolia essential oil used to treat silver catfish (Rhamdia quelen) experimentally infected by Aeromonas hydrophila on oxidative stress variables, and for the first time, on hepatic enzymes of the cholinergic and adenosinergic systems. For that, fish were divided into six groups (A-F), each containing seven animals. Groups A, B and C were composed of uninfected animals, while animals in groups D, E and F were intramuscularly inoculated with A. hydrophila...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27988165/increased-femoral-anteversion-influence-over-surgically-treated-recurrent-patellar-instability-patients
#17
Carlos Eduardo Franciozi, Luiz Felipe Ambra, Leonardo José Bernardes Albertoni, Pedro Debieux, Fernando Cury Rezende, Mauricio Ayres de Oliveira, Marcio de Castro Ferreira, Marcus Vinícius Malheiros Luzo
PURPOSE: To verify the influence that increased femoral anteversion (FA) has on patients with recurrent patellar instability (RPI) treated by anteromedialization tibial tubercle osteotomy (TTO) combined with medial patellofemoral ligament reconstruction (MPFLR) and to present the midterm outcomes of these patients. METHODS: From January 2008 to August 2013, skeletally mature patients with RPI and tibial tubercle (TT)-trochlear groove (TG) ≥ 17 mm who underwent anteromedialization TTO combined with MPFLR were evaluated for J sign, patellar glide, apprehension test, increased FA, Caton index, trochlea dysplasia, TT-TG, Kujala, International Knee Documentation Committee subjective knee evaluation form, and Tegner...
March 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27979118/encapsulation-of-tea-tree-oil-by-amorphous-beta-cyclodextrin-powder
#18
Meena Shrestha, Thao M Ho, Bhesh R Bhandari
An innovative method to encapsulate tea tree oil (TTO) by direct complexation with solid amorphous beta-cyclodextrin (β-CD) was investigated. A β-CD to TTO ratio of 90.5:9.5 (104.9mg TTO/g β-CD) was used in all complexation methods. The encapsulation was performed by direct mixing, and direct mixing was followed by the addition of water (13-17% moisture content, MC) or absolute ethanol (1:1, 1:2, 1:3 and 1:4 TTO:ethanol). The direct mixing method complexed the lowest amount of TTO (60.77mg TTO/g β-CD). Powder recrystallized using 17% MC included 99...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973040/assessment-of-utility-for-heart-failure-using-visual-analogue-scale-vas-time-trade-off-tto-and-euroqol-5-dimension-eq-5d-in-the-korean-general-population
#19
J Y Lee, E Lee
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27789761/applicability-of-patient-utilities-as-measures-of-overall-quality-of-life-in-rheumatoid-arthritis-clinical-trials
#20
Michael M Ward, Lori C Guthrie
OBJECTIVE: The aim was to determine whether the time trade-off (TTO) and standard gamble utilities can detect treatment-related improvement in overall quality of life in patients with active RA. METHODS: We measured TTO and standard gamble utilities in 192 patients before and after escalation of anti-rheumatic treatment in a prospective longitudinal study. We also examined associations between changes in utilities and patient-reported improvement during the study, and with EULAR responses...
October 27, 2016: Rheumatology
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