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Michael M Ward, Lori C Guthrie
OBJECTIVE: The aim was to determine whether the time trade-off (TTO) and standard gamble utilities can detect treatment-related improvement in overall quality of life in patients with active RA. METHODS: We measured TTO and standard gamble utilities in 192 patients before and after escalation of anti-rheumatic treatment in a prospective longitudinal study. We also examined associations between changes in utilities and patient-reported improvement during the study, and with EULAR responses...
October 27, 2016: Rheumatology
Danieli Urach Monteiro, Maria Isabel Azevedo, Carla Weiblen, Sônia DE Avila Botton, Nadine Lysyk Funk, Cristiane DE Bona DA Silva, Régis Adriel Zanette, Thiago Guilherme Schwanz, Mário Luiz DE LA Rue
Cystic echinococcosis is a zoonotic disease of difficult diagnosis and treatment. The use of protoscolicidal agents in procedures is of utmost importance for treatment success. This study was aimed at analysing the in vitro and ex vivo activity of Melaleuca alternifolia oil (tea tree oil - TTO), its nanoemulsion formulation (NE-TTO) and its major component (terpinen-4-ol) against Echinococcus ortleppi protoscoleces obtained from cattle. Concentrations of 2·5, 5 and 10 mg mL-1 of TTO, 10 mg mL-1 of NE-TTO and 1, 1·5 and 2 mg mL-1 of terpinen-4-ol were evaluated in vitro against protoscoleces at 5, 10, 15 and 30 min...
October 20, 2016: Parasitology
Mark R Brinker, Akash Trivedi, Daniel P O'Connor
OBJECTIVE: The purpose of this study is to report the extent of the effects of femoral nonunion on health-related quality of life. DESIGN: Retrospective cohort. SETTING: Tertiary referral center. PATIENTS/PARTICIPANTS: 187 consecutive patients (85 women, age 55.9 ± 16.9 years; 102 men, age 42.8 ± 16.1 years) with 188 nonunions of the femur, excluding those involving the hip or knee articular surfaces. INTERVENTION: Average nonunion duration was 28...
October 13, 2016: Journal of Orthopaedic Trauma
Feng Xie, Eleanor Pullenayegum, A Simon Pickard, Juan Manuel Ramos Goñi, Min-Woo Jo, Ataru Igarashi
Discrete choice experiments (DCEs) are a promising alternative to more resource-intensive preference elicitation methods such as time trade-off (TTO), as pairwise comparisons are more amenable to online completion, which can save time and money. However, modeling DCE data produces latent utilities which are on an unknown scale. Therefore, latent utilities need to be transformed to a full health-dead scale before they can be used in quality-adjusted life year calculations. We aimed to explore transformation functions from DCE-derived latent utilities to TTO-derived health utilities...
October 16, 2016: Health Economics
Rohit Tejwani, Hsin-Hsiao S Wang, Jessica C Lloyd, Paul J Kokorowski, Caleb P Nelson, Jonathan C Routh
BACKGROUND: The advent of online task-distribution has opened a new avenue to efficiently gather community perspectives needed for utility estimation. Methodological consensus for estimating pediatric utilities is lacking, with disagreement over whom to sample, what perspective (patient vs. parent), and whether instrument-induced anchoring bias is significant. We sought to determine what methodological factors potentially impact utility estimates for vesicoureteral reflux (VUR). DESIGN: Cross-sectional surveys using a time-trade-off (TTO) instrument were conducted via Amazon's Mechanical Turk online interface; respondents were randomized to answer questions from child, parent, or dyad perspectives on the utility of a VUR health state and one of three "warm-up" scenarios (paralysis, common cold, none) prior to a VUR scenario...
October 13, 2016: Journal of Urology
Shahid A Punwar, Daniel P Fick, Riaz J K Khan
BACKGROUND: Obtaining adequate exposure while maintaining the integrity of the extensor mechanism is crucial to the success of revision knee arthroplasty. This is particularly important in infected cases where staged procedures are necessary. While the use of a long, tibial tubercle osteotomy (TTO) is an established method to improve exposure, controversy still exists concerning complication rates and sequential use. METHODS: Forty-two TTOs were performed in revision knee arthroplasties between 2009 and 2015...
September 3, 2016: Journal of Arthroplasty
Joep H G Scholl, Eugène P van Puijenbroek
PURPOSE: In pharmacovigilance, the commonly used disproportionality analysis (DPA) in statistical signal detection is known to have its limitations. The aim of this study was to investigate the value of the time to onset (TTO) of ADRs in addition to DPA. METHODS: We performed a pilot study using individual case safety reports (ICSRs) for three drugs (Cervarix®, nitrofurantoin and simvastatin) from the Lareb spontaneous reporting database. TTO distributions for drug - ADR associations were compared to other ADRs for the same drug and to other drugs for the same ADR using two-sample Anderson-Darling testing...
December 2016: Pharmacoepidemiology and Drug Safety
Charlotte Pineau, Brice Lavrard, François Boyer, Laëtitia Percebois-Macadré
OBJECTIVE: MRI has highly changed the assessment of post-traumatic syringomyelia (PTS), roughly estimated at 30% nowadays. Times to onset (TTO) symptoms are random. This case report describes how hyperhidrosis appeared and revealed PTS diagnosis. OBSERVATIONS: Mr M., 43-year-old, is rehabilitation inpatient after T10 AIS A spinal cord injury (SCI). Three months after this event, Mr M complains of acute hyperhidrosis crisis always located below the injury, which can occur at any time of the day, particularly when he moves...
September 2016: Annals of Physical and Rehabilitation Medicine
Scott D Ramsey, Auayporn Nademanee, Tamas Masszi, Jerzy Holowiecki, Muneer Abidi, Andy Chen, Patrick Stiff, Simonetta Viviani, John W Sweetenham, John Radford, Yanyan Zhu, Vijayveer Bonthapally, Elizabeth Thomas, Akshara Richhariya, Naomi N Hunder, Jan Walewski, Craig H Moskowitz
Brentuximab vedotin (BV) significantly improved progression-free survival in a phase 3 study in patients with relapsed or refractory Hodgkin lymphoma (RR-HL) post-autologous-haematopoietic stem cell transplant (auto-HSCT); we report the impact of BV on quality of life (QOL) from this trial. The European Quality of Life five dimensions questionnaire was administered at the beginning of each cycle, end of treatment, and every 3 months during follow-up; index value scores were calculated using the time trade-off (TTO) method for UK-weighted value sets...
September 21, 2016: British Journal of Haematology
Thirssa H Grando, Matheus D Baldissera, Lucas T Gressler, Mariângela Facco de Sá, Bruna N Bortoluzzi, Andressa S Schafer, Rafael C Ebling, Renata P Raffin, Roberto C V Santos, Lenita M Stefani, Rodrigo Vaucher, Marta L R Leal, Silvia G Monteiro
Gastrointestinal parasites are one of the biggest health problems faced in sheep, mainly due to their pathogenicity and resistance to drugs used to control these parasites. Thus, the following study aimed to assess the anthelmintic efficacy of Melaleuca alternifolia against Haemonchus contortus in gerbils (Meriones unguiculatus) experimentally infected. Three treatments were tested: M. alternifolia essential oil, popularly known as tea tree oil (TTO), a solid lipid nanocarrier made with essential oil of Melaleuca (nanoTTO), and terpinen-4-ol (terp-4-ol)...
September 16, 2016: Experimental Parasitology
Angela Robinson, Anne E Spencer, José Luís Pinto-Prades, Judith A Covey
There is recent interest in using discrete choice experiments (DCEs) to derive health state utility values, and results can differ from time tradeoff (TTO). Clearly, DCE is "choice based," whereas TTO is generally considered a "matching" task. We explore whether procedural adaptations to the TTO, which make the method more closely resemble a DCE, make TTO and choice converge. In particular, we test whether making the matching procedure in TTO less "transparent" to the respondent reduces disparities between TTO and DCE...
September 19, 2016: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Chetan Purushottam Raut, Kunal S Sethi
BACKGROUND: Conventional nonsurgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Coenzyme Q10 and tea tree oil (TTO) are known to have potential therapeutic benefits in chronic periodontitis. AIMS: The aim of the study is to compare the efficacy of Coenzyme Q10 (Perio Q(®)) and tea tree oil (Melaleuca alternifolia) gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis...
July 2016: Contemporary Clinical Dentistry
Z Liu, R Meng, X Zhao, C Shi, X Zhang, Y Zhang, N Guo
: Listeria monocytogenes (L. monocytogenes) is a Gram-positive bacterium that causes infections in humans. In this study, the effects of tea tree oil (TTO) at subinhibitory concentrations on L. monocytogenes growth and two important exotoxin proteins secreted by L. monocytogenes were researched. Treatment with half of minimal inhibitory concentration of TTO demonstrated very little or no reduction in numbers of viable ATCC 19115 cells. Listeriolysin O (LLO) and p60, were investigated...
December 2016: Letters in Applied Microbiology
Takeru Shiroiwa, Shunya Ikeda, Shinichi Noto, Ataru Igarashi, Takashi Fukuda, Shinya Saito, Kojiro Shimozuma
BACKGROUND: The valuation study of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) involved composite time trade-off (cTTO) and a discrete choice experiment (DCE). The DCE scores must be anchored to the quality-of-life scale from 0 (death) to 1 (full health). Nevertheless, the characteristics of the statistical methods used for converting the EQ-5D-5L DCE results by using TTO information are not yet clearly known. OBJECTIVES: To present the Japanese DCE value set of the EQ-5D-5L and compare three methods for converting latent DCE values...
July 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Khan M Sharif, Chadin Kulsing, Philip J Marriott
The experimental approach and mechanism of pressure tuning (PT) are introduced for the first stage of a comprehensive two-dimensional gas chromatography (GC × GC) separation. The PT-GC × GC system incorporates a first dimension ((1)D) coupled column ensemble comprising a pair of (1)D columns ((1)D1 and (1)D2) connected via a microfluidic splitter device, allowing variable decompression of carrier gas across each (1)D column, and a conventional (2)D narrow bore column. By variation of junction pressure between the (1)D1 and (1)D2 columns, tunable total (1)D retentions of analytes are readily derived...
September 20, 2016: Analytical Chemistry
Noelle R Catarineu, Alexander Schoedel, Philipp Urban, Maureen B Morla, Christopher A Trickett, Omar M Yaghi
Structural diversity of metal-organic frameworks (MOFs) has been largely limited to linkers with at most two different types of coordinating groups. MOFs constructed from linkers with three or more nonidentical coordinating groups have not been explored. Here, we report a robust and porous crystalline MOF, Zn3(PBSP)2 or MOF-910, constructed from a novel linker PBSP (phenylyne-1-benzoate, 3-benzosemiquinonate, 5-oxidopyridine) bearing three distinct types of coordinative functionality. The MOF adopts a complex and previously unreported topology termed tto...
August 31, 2016: Journal of the American Chemical Society
Adam J N Raymakers, Nicole W Tsao, Carlo A Marra, Philip J Clements, Dinesh Khanna
OBJECTIVE: Health state utility values (HSUV) are used as weightings to calculate quality-adjusted life years in economic evaluations. Evidence suggests that patients' perceptions of a new diagnosis for a chronic disease, while initially poor, may improve over time. The objective of this study was to examine the association between disease duration and direct HSUV scores in patients with systemic sclerosis (SSc). METHODS: Our study included patients with SSc from a US SSc center...
October 2016: Journal of Rheumatology
Humza Khan, Karl Grob, Lachlan Peter Milne, Markus Stefan Kuster
: Adequate exposure is fundamental to safely and correctly perform open procedures around the knee. Tibial tubercle osteotomy (TTO) has previously been described as a method to improve exposure, particularly in complex primary elective knee arthroplasty or revision surgery. We describe a tibial tubercle osteotomy technique to improve exposure in complex knee fractures and a cadaveric study and trauma case series. METHODS: A cadaveric study using 8 knee specimens was conducted using a lateral subvastus approach to the knee...
October 2016: Injury
Michał Jakubczyk, Dominik Golicki, Maciej Niewada
PURPOSE: In most religions, the preservation of one's own, God-given, life is considered obligatory, while the time trade-off method (TTO) forces one to voluntarily forego life years. We sought to verify how this conflict impacts TTO-results among the religious. METHODS: We used the data from the only EQ-5D valuation in Poland (2008, three-level, 321 respondents, 23 states each)-a very religious, mostly Catholic country. We measured the religiosity with the belief in afterlife question on two levels: strong (definitely yes) and some (also rather yes), both about a third of the sample...
July 21, 2016: Quality of Life Research
Yulian Zhang, Zhongliang Zhou, Jianmin Gao, Dan Wang, Qian Zhang, Zhiying Zhou, Min Su, Dan Li
BACKGROUND: Hypertension is an important public health issue in China, but there are few studies on health-related quality of life (HRQoL) for patients with hypertension in China. This study aims to examine the HRQoL as measured by EQ-5D and investigate the factors that influence HRQoL for patients with hypertension in Shaanxi Province, China. METHODS: Data were collected from the Shaanxi's fifth National Health Service Survey conducted in 2013. EQ-5D was employed to measure the HRQoL for patients with hypertension...
2016: BMC Health Services Research
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