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https://www.readbyqxmd.com/read/28089949/melaleuca-alternifolia-nanoparticles-against-candida-species-biofilms
#1
M E Souza, L Q S Lopes, P C Bonez, A Gündel, D S T Martinez, M R Sagrillo, J L Giongo, R A Vaucher, R P Raffin, A A Boligon, R C V Santos
Candida infection is an important cause of morbidity and mortality on immunosuppressed patients. This growing trend has been associated with resistance to the antimicrobial therapy and the ability of microorganism to form biofilms. TTO oil is used as antimicrobial which shows antibiofilm activity against Candida species. However, it presents problems due to its poor solubility and high volatility. The present study aimed to evaluate in vitro antibiofilm activity of TTO nanoparticles against many Candida species...
January 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28074424/signal-detection-based-on-time-to-onset-algorithm-in-spontaneous-reporting-system-of-china
#2
Tianyi Zhang, Xiaofei Ye, Xiaojing Guo, Guizhi Wu, Yongfang Hou, Jinfang Xu, Wentao Shi, Tiantian Zhu, Yuan Zhang, Xinji Zhang, Jiaqi Song, Jia He
INTRODUCTION: The method of time-to-onset (TTO) has been proposed to overcome the drawbacks of traditional disproportionality analyses (DPAs), and it has been used for detecting safety signals of vaccines and some non-vaccine products in spontaneous reporting systems (SRSs). However, there is no consensus on its superiority over DPAs. Further, it is still not clear whether this novel approach can be generalized to the entire national SRS database. OBJECTIVE: The purpose of this study was to generalize the TTO method to the Chinese SRS and to identify suitable parameters for its optimal performance...
January 10, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28065959/clinical-profile-of-patients-with-biopsy-proven-lupus-nephritis-at-a-tertiary-care-hospital-from-northern-pakistan-1995-to-2012
#3
Akhtar Ali, Anjum Mehmood, Muhammad Usman Ali
OBJECTIVE: TTo highlight the clinical spectrum of biopsy-proven lupus nephritis by analysing any variations in its histological subtypes across gender, varying age groups, serum creatinine levels and anti-double stranded deoxyribonucleic acid levels. METHODS: This retrospective, observational study was conducted at the Lady Reading Hospital in collaboration with the Fauji Foundation Hospital, Peshawar, Pakistan, and comprised patient records of biopsy-proven lupus nephritis from 1995 to 2012...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28039941/time-to-onset-of-bisphosphonate-related-osteonecrosis-of-the-jaws-a-multicentre-retrospective-cohort-study
#4
Ppl Fung, G Bedogni, A Bedogni, A Petrie, S Porter, G Campisi, J Bagan, V Fusco, G Saia, S Acham, P Musto, M T Petrucci, P Diz, G Colella, M D Mignogna, M Pentenero, P Arduino, G Lodi, C Maiorana, M Manfredi, P Hallberg, M Wadelius, K Takaoka, Y Y Leung, R Bonacina, M Schiødt, P Lakatos, T Taylor, G De Riu, G Favini, S N Rogers, M Pirmohamed, P Nicoletti, S Fedele
OBJECTIVES: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. SUBJECTS AND METHODS: Retrospective analysis of data from 22 secondary care centres in 7 countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012...
December 31, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28028569/functional-testing-and-return-to-sport-following-stabilization-surgery-for-recurrent-lateral-patellar-instability-in-competitive-athletes
#5
Aaron J Krych, Michael P O'Malley, Nick R Johnson, Rohith Mohan, Timothy E Hewett, Michael J Stuart, Diane L Dahm
PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction and tibial tubercle osteotomy are commonly used to treat recurrent lateral patellar instability, yet there are limited available data on return to sport (RTS) following these procedures. The purpose of this study is to evaluate patient factors associated with excellent functional outcomes, including successful RTS, following surgical stabilization including MPFL reconstruction in competitive athletes with recurrent lateral patellar instability...
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28013459/molecular-and-structural-changes-induced-by-essential-oil-treatments-in-vicia-faba-roots-detected-by-ftir-and-ftnir-spectroscopy
#6
Mauro Mecozzi, Elena Sturchio, Priscilla Boccia, Miriam Zanellato, Claudia Meconi, Francesco Peleggi
Essential oils have recognized antimicrobial and antifungal properties which allow their utilization in agriculture like an alternative to pesticides, but their utilization requires the knowledge of all the potential structural changes and damages produced by the interaction with the vegetal organisms. In this paper, we investigated the effects of two essential oils, the tea tree oil (TTO) and the mixture of clove and rosemary oils (C + R), on the molecular structure of Vicia faba roots by Fourier transform infrared (FTIR) and Fourier near infrared transform (FTNIR) spectroscopy...
December 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27999505/osteochondral-allograft-transplantation-for-femoral-trochlear-dysplasia
#7
Dharmpal V Vansadia, James R Heltsley, Scott Montgomery, Misty Suri, Deryk G Jones
BACKGROUND: The risk factors for patellofemoral joint instability include laxity of medial patellar restraints, abnormal limb geometry, femoral and tibial malrotation, patella alta, and trochlear dysplasia. Femoral trochlear dysplasia is characterized by a hypoplastic or shallow trochlear groove. CASE REPORT: We report the case of a 31-year-old female with trochlear dysplasia and recurrent patella dislocations, laxity of the medial patellofemoral ligament (MPFL), and high-grade chondromalacia of the trochlea and the patella...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27988310/melaleuca-alternifolia-essential-oil-enhances-the-non-specific-immune-system-and-prevents-oxidative-damage-in-rhamdia-quelen-experimentally-infected-by-aeromonas-hydrophila-effects-on-cholinergic-and-purinergic-systems-in-liver-tissue
#8
Matheus D Baldissera, Carine F Souza, Guerino B Júnior, Agueda C de Vargas, Aline A Boligon, Marli M A de Campos, Lenita M Stefani, Bernardo Baldisserotto
The aim of this study was to evaluate the effects of M. alternifolia essential oil used to treat silver catfish (Rhamdia quelen) experimentally infected by Aeromonas hydrophila on oxidative stress variables, and for the first time, on hepatic enzymes of the cholinergic and adenosinergic systems. For that, fish were divided into six groups (A-F), each containing seven animals. Groups A, B and C were composed of uninfected animals, while animals in groups D, E and F were intramuscularly inoculated with A. hydrophila...
December 14, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27988165/increased-femoral-anteversion-influence-over-surgically-treated-recurrent-patellar-instability-patients
#9
Carlos Eduardo Franciozi, Luiz Felipe Ambra, Leonardo José Bernardes Albertoni, Pedro Debieux, Fernando Cury Rezende, Mauricio Ayres de Oliveira, Marcio de Castro Ferreira, Marcus Vinícius Malheiros Luzo
PURPOSE: To verify the influence that increased femoral anteversion (FA) has on patients with recurrent patellar instability (RPI) treated by anteromedialization tibial tubercle osteotomy (TTO) combined with medial patellofemoral ligament reconstruction (MPFLR) and to present the midterm outcomes of these patients. METHODS: From January 2008 to August 2013, skeletally mature patients with RPI and tibial tubercle (TT)-trochlear groove (TG) ≥ 17 mm who underwent anteromedialization TTO combined with MPFLR were evaluated for J sign, patellar glide, apprehension test, increased FA, Caton index, trochlea dysplasia, TT-TG, Kujala, International Knee Documentation Committee subjective knee evaluation form, and Tegner...
December 14, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27979118/encapsulation-of-tea-tree-oil-by-amorphous-beta-cyclodextrin-powder
#10
Meena Shrestha, Thao M Ho, Bhesh R Bhandari
An innovative method to encapsulate tea tree oil (TTO) by direct complexation with solid amorphous beta-cyclodextrin (β-CD) was investigated. A β-CD to TTO ratio of 90.5:9.5 (104.9mg TTO/g β-CD) was used in all complexation methods. The encapsulation was performed by direct mixing, and direct mixing was followed by the addition of water (13-17% moisture content, MC) or absolute ethanol (1:1, 1:2, 1:3 and 1:4 TTO:ethanol). The direct mixing method complexed the lowest amount of TTO (60.77mg TTO/g β-CD). Powder recrystallized using 17% MC included 99...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973040/assessment-of-utility-for-heart-failure-using-visual-analogue-scale-vas-time-trade-off-tto-and-euroqol-5-dimension-eq-5d-in-the-korean-general-population
#11
J Y Lee, E Lee
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27789761/applicability-of-patient-utilities-as-measures-of-overall-quality-of-life-in-rheumatoid-arthritis-clinical-trials
#12
Michael M Ward, Lori C Guthrie
OBJECTIVE: The aim was to determine whether the time trade-off (TTO) and standard gamble utilities can detect treatment-related improvement in overall quality of life in patients with active RA. METHODS: We measured TTO and standard gamble utilities in 192 patients before and after escalation of anti-rheumatic treatment in a prospective longitudinal study. We also examined associations between changes in utilities and patient-reported improvement during the study, and with EULAR responses...
October 27, 2016: Rheumatology
https://www.readbyqxmd.com/read/27762176/in-vitro-and-ex-vivo-activity-of-melaleuca-alternifolia-against-protoscoleces-of-echinococcus-ortleppi
#13
Danieli Urach Monteiro, Maria Isabel Azevedo, Carla Weiblen, Sônia DE Avila Botton, Nadine Lysyk Funk, Cristiane DE Bona DA Silva, Régis Adriel Zanette, Thiago Guilherme Schwanz, Mário Luiz DE LA Rue
Cystic echinococcosis is a zoonotic disease of difficult diagnosis and treatment. The use of protoscolicidal agents in procedures is of utmost importance for treatment success. This study was aimed at analysing the in vitro and ex vivo activity of Melaleuca alternifolia oil (tea tree oil - TTO), its nanoemulsion formulation (NE-TTO) and its major component (terpinen-4-ol) against Echinococcus ortleppi protoscoleces obtained from cattle. Concentrations of 2·5, 5 and 10 mg mL-1 of TTO, 10 mg mL-1 of NE-TTO and 1, 1·5 and 2 mg mL-1 of terpinen-4-ol were evaluated in vitro against protoscoleces at 5, 10, 15 and 30 min...
October 20, 2016: Parasitology
https://www.readbyqxmd.com/read/27755332/the-debilitating-effects-of-femoral-nonunion-on-health-related-quality-of-life
#14
Mark R Brinker, Akash Trivedi, Daniel P O'Connor
OBJECTIVE: The purpose of this study is to report the extent of the effects of femoral nonunion on health-related quality of life. DESIGN: Retrospective cohort. SETTING: Tertiary referral center. PATIENTS/PARTICIPANTS: 187 consecutive patients (85 women, age 55.9 ± 16.9 years; 102 men, age 42.8 ± 16.1 years) with 188 nonunions of the femur, excluding those involving the hip or knee articular surfaces. INTERVENTION: Average nonunion duration was 28...
October 13, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27747973/transforming-latent-utilities-to-health-utilities-east-does-not-meet-west
#15
Feng Xie, Eleanor Pullenayegum, A Simon Pickard, Juan Manuel Ramos Goñi, Min-Woo Jo, Ataru Igarashi
Discrete choice experiments (DCEs) are a promising alternative to more resource-intensive preference elicitation methods such as time trade-off (TTO), as pairwise comparisons are more amenable to online completion, which can save time and money. However, modeling DCE data produces latent utilities which are on an unknown scale. Therefore, latent utilities need to be transformed to a full health-dead scale before they can be used in quality-adjusted life year calculations. We aimed to explore transformation functions from DCE-derived latent utilities to TTO-derived health utilities...
October 16, 2016: Health Economics
https://www.readbyqxmd.com/read/27746280/utility-estimation-for-pediatric-vesicoureteral-reflux-methodological-considerations-using-an-online-survey-platform
#16
Rohit Tejwani, Hsin-Hsiao S Wang, Jessica C Lloyd, Paul J Kokorowski, Caleb P Nelson, Jonathan C Routh
PURPOSE: The advent of online task distribution has opened a new avenue for efficiently gathering community perspectives needed for utility estimation. Methodological consensus for estimating pediatric utilities is lacking, with disagreement over whom to sample, what perspective to use (patient vs parent) and whether instrument induced anchoring bias is significant. We evaluated what methodological factors potentially impact utility estimates for vesicoureteral reflux. MATERIALS AND METHODS: Cross-sectional surveys using a time trade-off instrument were conducted via the Amazon Mechanical Turk (https://www...
October 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27692784/tibial-tubercle-osteotomy-in-revision-knee-arthroplasty
#17
Shahid A Punwar, Daniel P Fick, Riaz J K Khan
BACKGROUND: Obtaining adequate exposure while maintaining the integrity of the extensor mechanism is crucial to the success of revision knee arthroplasty. This is particularly important in infected cases where staged procedures are necessary. While the use of a long, tibial tubercle osteotomy (TTO) is an established method to improve exposure, controversy still exists concerning complication rates and sequential use. METHODS: Forty-two TTOs were performed in revision knee arthroplasties between 2009 and 2015...
September 3, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27686554/the-value-of-time-to-onset-in-statistical-signal-detection-of-adverse-drug-reactions-a-comparison-with-disproportionality-analysis-in-spontaneous-reports-from-the-netherlands
#18
Joep H G Scholl, Eugène P van Puijenbroek
PURPOSE: In pharmacovigilance, the commonly used disproportionality analysis (DPA) in statistical signal detection is known to have its limitations. The aim of this study was to investigate the value of the time to onset (TTO) of ADRs in addition to DPA. METHODS: We performed a pilot study using individual case safety reports (ICSRs) for three drugs (Cervarix®, nitrofurantoin and simvastatin) from the Lareb spontaneous reporting database. TTO distributions for drug - ADR associations were compared to other ADRs for the same drug and to other drugs for the same ADR using two-sample Anderson-Darling testing...
December 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27676770/inaugural-hyperhidrosis-revealing-syringomyelia-in-a-spinal-cord-injured-men-t10-ais-a
#19
Charlotte Pineau, Brice Lavrard, François Boyer, Laëtitia Percebois-Macadré
OBJECTIVE: MRI has highly changed the assessment of post-traumatic syringomyelia (PTS), roughly estimated at 30% nowadays. Times to onset (TTO) symptoms are random. This case report describes how hyperhidrosis appeared and revealed PTS diagnosis. OBSERVATIONS: Mr M., 43-year-old, is rehabilitation inpatient after T10 AIS A spinal cord injury (SCI). Three months after this event, Mr M complains of acute hyperhidrosis crisis always located below the injury, which can occur at any time of the day, particularly when he moves...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27649689/quality-of-life-results-from-a-phase-3-study-of-brentuximab-vedotin-consolidation-following-autologous-haematopoietic-stem-cell-transplant-for-persons-with-hodgkin-lymphoma
#20
Scott D Ramsey, Auayporn Nademanee, Tamas Masszi, Jerzy Holowiecki, Muneer Abidi, Andy Chen, Patrick Stiff, Simonetta Viviani, John W Sweetenham, John Radford, Yanyan Zhu, Vijayveer Bonthapally, Elizabeth Thomas, Akshara Richhariya, Naomi N Hunder, Jan Walewski, Craig H Moskowitz
Brentuximab vedotin (BV) significantly improved progression-free survival in a phase 3 study in patients with relapsed or refractory Hodgkin lymphoma (RR-HL) post-autologous-haematopoietic stem cell transplant (auto-HSCT); we report the impact of BV on quality of life (QOL) from this trial. The European Quality of Life five dimensions questionnaire was administered at the beginning of each cycle, end of treatment, and every 3 months during follow-up; index value scores were calculated using the time trade-off (TTO) method for UK-weighted value sets...
September 21, 2016: British Journal of Haematology
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