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https://www.readbyqxmd.com/read/29321017/influence-of-the-child-s-perceived-general-health-on-the-primary-caregiver-s-health-status
#1
Janine Verstraete, Lebogang Ramma, Jennifer Jelsma
BACKGROUND: In estimating the impact of an intervention, ignoring the effect of improving the health of one member of the caregiver/child dyad on the Health Related Quality of Life (HRQoL) of the other member may lead to an underestimation of the utility gained. This may be particularly true for infants/young children and their caregivers. The aim of this study was to quantify the interaction between the child's perceived general health as assessed by the newly developed Toddler and Infant Questionnaire (TANDI) on the reporting of the caregiver's own HRQoL as assessed by the EQ-5D-3 L...
January 10, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29309758/anti-thrombotic-efficacy-of-s007-867-pre-clinical-evaluation-in-experimental-models-of-thrombosis-in-vivo-and-in-vitro
#2
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown better antithrombotic protection than aspirin and clopidogrel with minimal bleeding tendency in mice. The present study is aimed to systematically investigate the antithrombotic efficacy of S007-867 in comparison to aspirin and clopidogrel in vivo and to delineate its mechanism of action in vitro...
January 5, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29309452/a-systematic-review-of-21-tibial-tubercle-osteotomy-studies-and-more-than-1000-knees-indications-clinical-outcomes-complications-and-reoperations
#3
Bryan M Saltzman, Allison Rao, Brandon J Erickson, Gregory L Cvetanovich, David Levy, Bernard R Bach, Brian J Cole
Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched the literature for tibial tubercle osteotomy (TTO) studies and systematically reviewed them for indications, clinical outcomes, complications, and reoperations. Therapeutic clinical studies that reported TTO indications, operative findings, and outcomes were included. Quality of each study was assessed with the modified Coleman methodology score (MCMS). Twenty-one studies (976 patients, 1055 knees) were included in the analysis...
November 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29290074/reported-time-to-onset-of-neurological-adverse-drug-reactions-among-different-age-and-gender-groups-using-metoclopramide-an-analysis-of-the-global-database-vigibase%C3%A2
#4
Kristian Svendsen, Mollie Wood, Erika Olsson, Hedvig Nordeng
PURPOSE: Despite FDA and EMA warnings of long-term use, little is known regarding the time to onset (TTO) of neurological adverse drug reactions (ADR) for metoclopramide. The aims of this study were, first, to evaluate whether neurological ADRs are more commonly reported for metoclopramide than for other medications, and second, to describe how time to onset of neurological ADRs differs by age and gender. METHODS: All ADR reports with metoclopramide as the suspected/interacting drug were extracted from the WHOs Global ADR database Vigibase® between 1967 and May 2016...
December 30, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29270984/g-protein-coupled-receptor-gpr34l-mutation-affects-thrombocyte-function-in-zebrafish
#5
Seongcheol Kim, Abdullah Alsrhani, Lala Zafreen, Gauri Khandekar, Florence L Marlow, Elliott W Abrams, Mary C Mullins, Pudur Jagadeeswaran
Haemostasis is a defence mechanism that has evolved to protect organisms from losing their circulating fluid. We have previously introduced zebrafish as a model to study the genetics of haemostasis to identify novel genes that play a role in haemostasis. Here, we identify a zebrafish mutant that showed prolonged time to occlusion (TTO) in the laser injury venous thrombosis assay. By linkage analysis and fine mapping, we found a mutation in the orphan G protein-coupled receptor 34 like gene (gpr34l) causing a change of Val to Glu in the third external loop of Gpr34l...
December 21, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29241900/a-latent-class-of-their-own-response-patterns-in-trading-off-quantity-and-quality-of-life-in-time-trade-off-exercises
#6
F E van Nooten, K Houghton, J van Exel, M van Agthoven, W B F Brouwer, D E Stull
BACKGROUND: Conflicting results regarding associations of time trade-off (TTO) valuations with respondent characteristics have been reported, mostly on the basis of regression analyses. Alternative approaches, such as the latent class analysis (LCA), may add to the further understanding of variations in TTO responses. OBJECTIVES: To identify whether subgroups of respondents can be identified on the basis of their responses to TTO exercises and to investigate which respondent characteristics are associated with membership of the identified subgroups...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29240836/is-quality-of-life-different-between-diabetic-and-non-diabetic-people-the-importance-of-cardiovascular-risks
#7
L M Peña-Longobardo, B Rodríguez-Sánchez, M Mata-Cases, L Rodríguez-Mañas, M Capel, J Oliva-Moreno
BACKGROUND: To analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community. METHODS: We used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011-2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29235059/quality-of-life-after-hip-vertebral-and-distal-forearm-fragility-fractures-measured-using-the-eq-5d-3l-eq-vas-and-time-trade-off-results-from-the-icuros
#8
Axel Svedbom, Fredrik Borgström, Emma Hernlund, Oskar Ström, Vidmantas Alekna, Maria Luisa Bianchi, Patricia Clark, Manuel Díaz Curiel, Hans Peter Dimai, Mikk Jürisson, Anneli Uusküla, Margus Lember, Riina Kallikorm, Olga Lesnyak, Eugene McCloskey, Olga Ershova, Kerrie M Sanders, Stuart Silverman, Marija Tamulaitiene, Thierry Thomas, Anna N A Tosteson, Bengt Jönsson, John A Kanis
INTRODUCTION: The International Costs and Utilities Related to Osteoporotic fractures Study is a multinational observational study set up to describe the costs and quality of life (QoL) consequences of fragility fracture. This paper aims to estimate and compare QoL after hip, vertebral, and distal forearm fracture using time-trade-off (TTO), the EuroQol (EQ) Visual Analogue Scale (EQ-VAS), and the EQ-5D-3L valued using the hypothetical UK value set. METHODS: Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall), and at 4, 12, and 18 months after fracture...
December 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29229415/return-to-sports-after-tibial-tubercle-osteotomy-for-patellofemoral-pain-and-osteoarthritis
#9
Joseph N Liu, Hao-Hua Wu, Grant H Garcia, Irene L Kalbian, Sabrina M Strickland, Beth E Shubin Stein
PURPOSE: To determine the rate of return to sports and clinical outcomes after anteromedialization (AMZ) tibial tubercle osteotomy (TTO) for patients with patellofemoral pain and/or osteoarthritis. METHODS: This study is a retrospective case series of consecutive patients who underwent unilateral or staged bilateral AMZ TTO for a primary diagnosis of patellofemoral pain or arthritis. Included were all patients with minimum 1-year follow-up. The indication for surgery was failure of at least 6 months of nonoperative treatment...
December 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29218583/promising-antibacterial-effects-of-silver-nanoparticle-loaded-tea-tree-oil-nanoemulsion-a-synergistic-combination-against-resistance-threat
#10
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharazi, Samira Rasoulikoohi, Amir Amani
Highly resistant pathogens may be developed in patients with immune disorders after prolonged exposure to antibiotics, a growing threat worldwide. In order to overcome these problems, this study introduces a new class of engineered nanosystems comprising of tea tree oil nanoemulsion (TTO NE) loaded with Ag nanoparticles (NPs). Silver shows a strong toxicity towards a wide range of microorganisms. Also, TTO NE could be employed as a promising and safe antimicrobial agent for local therapies of bacterial infections...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29178918/health-state-utilities-associated-with-attributes-of-weekly-injection-devices-for-treatment-of-type-2-diabetes
#11
Louis S Matza, Kristina S Boye, Katie D Stewart, Evan W Davies, Rosirene Paczkowski
BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists are often recommended as part of combination therapy for type 2 diabetes when oral medication does not result in sufficient glycemic control. Several GLP-1 receptor agonists are available as weekly injections. These medications vary in their injection delivery systems, and these differences could impact quality of life and treatment preference. The purpose of this study was to estimate utilities associated with attributes of injection delivery systems for weekly GLP-1 therapies...
November 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29162482/antimicrobial-activity-of-melaleuca-alternifolia-nanoparticles-in-polymicrobial-biofilm-in-situ
#12
Márcia Ebling de Souza, Dariane Jornada Clerici, Camila Marina Verdi, Gabriela Fleck, Priscilla Maciel Quatrin, Luana Ebling Spat, Pauline Cordenonsi Bonez, Camilla Fillippi Dos Santos, Raquel Pippi Antoniazzi, Fabrício Batistin Zanatta, André Gundel, Diego Stefani Teodoro Martinez, Rodrigo de Almeida Vaucher, Roberto Christ Vianna Santos
Microbial biofilms represent a challenge in the treatment of infections, due to the low efficacy of the antimicrobials. This study evaluated the antimicrobial effect of nanoparticles of Melaleuca alternifolia (TTO) in dental biofilm. Thirty-eight volunteers used an oral device in situ in situ including four bovine enamel specimens for 07 days. From the fifth day four solutions were applied randomly for each specimen: Physiological Saline Solution (0.85% NaCl) (C+), Chlorhexidine 0.12% (CHX), M. alternifolia oil 0...
November 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29137160/the-influence-of-toothpaste-containing-australian-melaleuca-alternifolia-oil-and-ethanolic-extract-of-polish-propolis-on-oral-hygiene-and-microbiome-in-patients-requiring-conservative-procedures
#13
Tomasz Piekarz, Anna Mertas, Karolina Wiatrak, Rafał Rój, Patryk Kownacki, Joanna Śmieszek-Wilczewska, Ewelina Kopczyńska, Maciej Wrzoł, Maria Cisowska, Ewelina Szliszka, Zenon P Czuba, Iwona Niedzielska, Tadeusz Morawiec
The study was based on the use of a toothpaste with antiphlogistic activity, containing Australian Melaleuca alternifolia oil (tea tree oil-TTO) and ethanolic extract of Polish propolis (EEP). Fifty-one patients with varying conditions of the gingiva were divided into two groups. The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. Approximal plaque index (API), simplified oral hygiene index (OHI-s) and modified sulcus bleeding index (mSBI) were assessed in three subsequent stages...
November 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29125514/crowdsourcing-utility-estimation-for-spina-bifida-in-the-general-population
#14
Ruiyang Jiang, Brian M Inouye, Hsin-Hsiao S Wang, Rohit Tejwani, Jonathan C Routh
INTRODUCTION: Cost-utility analyses (CUA) are useful when the treatment conditions depend on patient preferences that are in turn dependent on health state utility value. Spina bifida (SB) is an example of such a preference-sensitive condition. Historically, the SB utility value for CUA has been gathered via a traditional face-to-face interview. However, due to funding and time constrains, utility estimation via online crowdsourcing has recently gained popularity. Our aim was to estimate the utility value for a generic SB health state using a validated online tool...
December 11, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29125377/intraflagellar-transport-proteins-are-involved-in-thrombocyte-filopodia-formation-and-secretion
#15
Uvaraj Radhakrishnan, Abdullah Alsrhani, Hemalatha Sundaramoorthi, Gauri Khandekar, Meghana Kashyap, Jannon L Fuchs, Brian D Perkins, Yoshihiro Omori, Pudur Jagadeeswaran
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary cilia was unexpected. IFT proteins serve transport in cilia, whose narrow dimensions may have necessitated the evolution of IFT from vesicular transport in ancestral eukaryotes. We hypothesized that IFTs might also facilitate transport within the filopodia that form when thrombocytes are activated. To test this possibility, we knocked down ift122 expression by injecting antisense Morpholino oligonucleotides (MOs) into zebrafish embryos...
November 10, 2017: Platelets
https://www.readbyqxmd.com/read/29111062/plasma-treated-poly-ethylene-oxide-nanofibers-containing-tea-tree-oil-beta-cyclodextrin-inclusion-complex-for-antibacterial-packaging
#16
Haiying Cui, Mei Bai, Lin Lin
This work describes the effect of cold nitrogen plasma to enhance the antibacterial activity of poly(ethylene oxide) (PEO) nanofibers containing antibacterial agent. Beta-cyclodextrin (β-CD) and tea tree oil (TTO) were used as a host-guest to form water-soluble inclusion complex. The encapsulation efficiency of TTO in inclusion complex could reach 73.23% at 60°C. As antibacterial agent, the inclusion complex was encapsulated into PEO matrix by electrospun. After plasma treatment, the release efficiency of antibacterial agent from PEO nanofibers was improved...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29075250/itraq-proteomic-analysis-reveals-that-metabolic-pathways-involving-energy-metabolism-are-affected-by-tea-tree-oil-in-botrytis-cinerea
#17
Jiayu Xu, Xingfeng Shao, Yingying Wei, Feng Xu, Hongfei Wang
Tea tree oil (TTO) is a volatile essential oil obtained from the leaves of the Australian tree Melaleuca alternifolia by vapor distillation. Previously, we demonstrated that TTO has a strong inhibitory effect on Botrytis cinerea. This study investigates the underlying antifungal mechanisms at the molecular level. A proteomics approach using isobaric tags for relative and absolute quantification (iTRAQ) was adopted to investigate the effects of TTO on B. cinerea. A total of 718 differentially expression proteins (DEPs) were identified in TTO-treated samples, 17 were markedly up-regulated and 701 were significantly down-regulated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29052157/a-review-of-generic-preference-based-measures-for-use-in-cost-effectiveness-models
#18
REVIEW
John Brazier, Roberta Ara, Donna Rowen, Helene Chevrou-Severac
Generic preference-based measures (GPBMs) of health are used to obtain the quality adjustment weight required to calculate the quality-adjusted life year in health economic models. GPBMs have been developed to use across different interventions and medical conditions and typically consist of a self-complete patient questionnaire, a health state classification system, and preference weights for all states defined by the classification system. Of the six main GPBMs, the three most frequently used are the Health Utilities Index version 3, the EuroQol 5 dimensions (3 and 5 levels), and the Short Form 6 dimensions...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29019161/assessing-the-use-of-a-feedback-module-to-model-eq-5d-5l-health-states-values-in-hong-kong
#19
Eliza L Y Wong, Juan Manuel Ramos-Goñi, Annie W L Cheung, Amy Y K Wong, Oliver Rivero-Arias
BACKGROUND: An international valuation protocol exists for obtaining societal values for each of the 3125 health states of the five-level EuroQol-five dimensions (EQ-5D-5L) questionnaire. A feedback module (FM) that can be related to theoretical models used in behavioral economics was recently included in this protocol. OBJECTIVES: Our objective was to assess the impact of using an FM to estimate an EQ-5D-5L value set in Hong Kong. METHODS: EQ-5D-5L health states were elicited using a composite time trade-off (C-TTO) and a discrete-choice (DC) experiment...
October 10, 2017: Patient
https://www.readbyqxmd.com/read/29019023/challenges-associated-with-estimating-utility-in-wet-age-related-macular-degeneration-a-novel-regression-analysis-to-capture-the-bilateral-nature-of-the-disease
#20
Robert Hodgson, Timothy Reason, David Trueman, Rose Wickstead, Jeanette Kusel, Adam Jasilek, Lindsay Claxton, Matthew Taylor, Ruth Pulikottil-Jacob
INTRODUCTION: The estimation of utility values for the economic evaluation of therapies for wet age-related macular degeneration (AMD) is a particular challenge. Previous economic models in wet AMD have been criticized for failing to capture the bilateral nature of wet AMD by modelling visual acuity (VA) and utility values associated with the better-seeing eye only. METHODS: Here we present a de novo regression analysis using generalized estimating equations (GEE) applied to a previous dataset of time trade-off (TTO)-derived utility values from a sample of the UK population that wore contact lenses to simulate visual deterioration in wet AMD...
October 2017: Advances in Therapy
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