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Renal cell carcinoma, kidney, bladder cancer, prostate

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https://www.readbyqxmd.com/read/27891445/breast-cancer-with-synchronous-renal-cell-carcinoma-a-rare-presentation
#1
Ravi Arjunan, Durgesh Kumar, K V Veerendra Kumar, C S Premlatha
Primary cancer arising from multiple organs is a well known fact. Synchronous tumours have been most commonly associated with kidney cancer. Bladder, prostate, colorectal and lung cancer are the most common synchronous primaries with Renal Cell Carcinoma (RCC) identified till date. We found metachronous tumours of breast with RCC in literature search which included both metastatic tumours as well second primaries. Overall, 25 cases of metastatic breast tumours and eight cases of second primary in previously treated RCC have been reported in the literature...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27819754/urological-cancer-related-to-familial-syndromes
#2
Walter Henriques da Costa, George Jabboure, Isabela Werneck da Cunha
Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such as hereditary leiomyomatosis renal cell carcinoma (HLRCC), succinate de¬hydrogenase kidney cancer (SDH-RCC), and more recently BAP1 germline mutation re¬lated RCC...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27695045/tumor-specific-epigenetic-silencing-of-corticotropin-releasing-hormone-binding-protein-in-renal-cell-carcinoma-association-of-hypermethylation-and-metastasis
#3
Hossein Tezval, Natalia Dubrowinskaja, Inga Peters, Christel Reese, Katrin Serth, Faranaz Atschekzei, Jörg Hennenlotter, Arnulf Stenzl, Markus A Kuczyk, Jürgen Serth
The relevance of Corticotropin Releasing Hormone (CRH)-system in human malignancies is a question of growing interest. Here we investigated hypermethylation and epigenetic silencing of the CRH-Binding Protein (CRHBP) gene in clear cell renal cell cancer (ccRCC). Relative methylation of the CRHBP CpG island (CGI) was determined in 17 tumor cell lines as well as 86 ccRCC samples and 66 paired normal tissues using pyrosequencing and quantitative methylation specific PCR of bisulfite converted DNA. Results were statistically compared with relative mRNA expression levels of CRHBP and clinicopathological parameters of patients...
2016: PloS One
https://www.readbyqxmd.com/read/27398803/independent-pre-transplant-recipient-cancer-risk-factors-after-kidney-transplantation-and-the-utility-of-g-chart-analysis-for-clinical-process-control
#4
Harald Schrem, Valentin Schneider, Marlene Kurok, Alon Goldis, Maren Dreier, Alexander Kaltenborn, Wilfried Gwinner, Marc Barthold, Jan Liebeneiner, Markus Winny, Jürgen Klempnauer, Moritz Kleine
BACKGROUND: The aim of this study is to identify independent pre-transplant cancer risk factors after kidney transplantation and to assess the utility of G-chart analysis for clinical process control. This may contribute to the improvement of cancer surveillance processes in individual transplant centers. PATIENTS AND METHODS: 1655 patients after kidney transplantation at our institution with a total of 9,425 person-years of follow-up were compared retrospectively to the general German population using site-specific standardized-incidence-ratios (SIRs) of observed malignancies...
2016: PloS One
https://www.readbyqxmd.com/read/27049022/urologic-cancer-in-china
#5
REVIEW
Cheng Pang, Youyan Guan, Hongbo Li, Wanqing Chen, Gang Zhu
Cancer remains to be the second most common cause of death, and its incidence and mortality rates are increasing in China. According to the 2015 National Central Cancer Registry (NCCR) of China, the incidence of bladder cancer and prostate cancer ranked sixth and seventh, respectively, in male cancers. The majority of prostate cancer patients were diagnosed at an advanced stage. Early diagnosis of prostate cancer is the key to improve prostate cancer survival in China. Radical prostatectomy or radical radiotherapy is the main treatment for localized prostate cancer, and a comprehensive therapy based on androgen deprivation therapy is the treatment for advanced disease...
June 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26843415/does-solitary-and-organ-confined-metastasectomy-really-improve-survival-in-advanced-urologic-malignancies
#6
REVIEW
Senol Tonyali, Sertac Yazici
The role of metastasectomy on survival in advanced/urologic malignancies still remains unclear. Renal cell carcinoma (RCC) is the most common solid tumor within the kidney. 25-30 % of patients have metastases at manifestation. Urothelial carcinoma (UC) consists of bladder carcinoma, upper urinary tract urothelial cell carcinoma and urethral carcinoma. Bladder cancer is the ninth most common cancer worldwide. Half of patients with muscle invasive bladder cancer have lymph node or distant metastases. In metastatic disease first-line treatment is multi-agent platinum-based systemic chemotherapy...
May 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26615524/polyomavirus-large-t-antigen-is-prevalent-in-urothelial-carcinoma-post-kidney-transplant
#7
Ling Yan, Mohamed E Salama, Christian Lanciault, Linh Matsumura, Megan L Troxell
Viral pathogens have been associated with both infectious disease and neoplasia in transplant recipients. Polyomavirus is emerging as a potential causative agent for genitourinary tract cancer in post-kidney transplant patients. Human papillomavirus (HPV) has a proven role in squamous cancers, but has not been studied in genitourinary malignancies in transplantation. Of 2345 kidney transplants performed at our center over the past 20 years, we identified 16 patients with 20 genitourinary cancers (0.7%), including 13 bladder/ureter carcinomas, 5 renal cell carcinomas (RCCs), and 2 prostate carcinomas...
February 2016: Human Pathology
https://www.readbyqxmd.com/read/26355159/urologic-cancer-in-thailand
#8
REVIEW
Bannakij Lojanapiwat
Cancer is a major health burden among non-communicable diseases, which has had a high impact on the healthcare system in Thailand. Based on GLOBOCAN, the prevalence of urologic cancer is increasing in Thailand. Prostate, bladder and kidney cancers are 6th, 15th and 22nd most common cancers, respectively, in both males and females. Prostate cancer is the fourth most common cancer in male. Cancer in the lower socioeconomic groups is a challenging problem due to greater exposure to the risk factors and more limited access to the healthcare service...
November 2015: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26257975/sarcomatoid-renal-cell-carcinoma-metastasis-to-the-penis
#9
Victor D Liou, Oussama M Darwish, Mary M Henry, Ik C Jun, Sameer A Siddiqui
Secondary cancers of the penis are extremely uncommon with less than 300 cases reported in the past 100 years. These cancers are most frequently a result of an aggressive or poorly managed primary prostate or bladder cancer and rarely a metastasis from a primary kidney tumor. Currently, there is no published literature which describes the spread of sarcomatoid renal cell carcinoma (SRCC) to the penis. In this report, we present a 55-year-old-man who presented with a large right-sided SRCC which metastasized to the base of his penis within 1 month of symptom onset...
2015: Case Reports in Urology
https://www.readbyqxmd.com/read/26251734/the-role-of-epigenetics-in-kidney-malignancies
#10
REVIEW
Alfredo Harb-De la Rosa, Matthew Acker, Sanjaya Swain, Murugesan Manoharan
INTRODUCTION: Renal cell carcinomas (RCC) are collectively the third most common type of genitourinary neoplasms, surpassed only by prostate and bladder cancer. Cure rates for renal cell carcinoma are related to tumor grade and stage; therefore, diagnostic methods for early detection and new therapeutic modalities are of paramount importance. Epigenetics can be defined as inherited modifications in gene expression that are not encoded in the DNA sequence itself. Epigenetics may play an important role in the pursuit of early diagnosis, accurate prognostication and identification of new therapeutic targets...
2015: Central European Journal of Urology
https://www.readbyqxmd.com/read/26085688/urologic-cancer-in-indonesia
#11
REVIEW
Rainy Umbas, Ferry Safriadi, Chaidir A Mochtar, Wahjoe Djatisoesanto, Agus Rizal A H Hamid
Non-communicable diseases, including cancer, start to become more common in Indonesia. According to the government statement, incidence of malignant diseases increased annually up to 8% in the last decade and these diseases become the seventh leading cause of death in Indonesia. On the basis of the latest Globocan report on cancer incidence in Indonesia, prostate cancer ranks sixth; followed by bladder (12th) and kidney (18th). More than half of patients with kidney cancer are diagnosed in the advanced stage...
August 2015: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25804448/pecomas-of-the-kidney-and-of-the-genitourinary-tract
#12
REVIEW
Guido Martignoni, Maurizio Pea, Claudia Zampini, Matteo Brunelli, Diego Segala, Giuseppe Zamboni, Franco Bonetti
PEComas are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells that are characterized by the coexpression of muscle and melanogenetic markers. This group of lesions includes angiomyolipoma, clear cell "sugar" tumor of the lung and extrapulmonary sites, lymphangioleiomyomatosis, clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres, and rare clear cell tumors of other anatomical sites. In the genitourinary tract, PEComas have been described in the kidney, bladder, prostate, testis, and urethra...
March 2015: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/25600760/effect-of-perioperative-blood-transfusion-on-mortality-for-major-urologic-malignancies
#13
Ayman Soubra, Joseph R Zabell, Oluwakayode Adejoro, Badrinath R Konety
INTRODUCTION: Patients who undergo surgical treatment for malignancy often receive perioperative blood transfusion (PBT). We examined the association between PBT and mortality in patients who received surgical treatment of prostate, bladder, and kidney cancer. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare data set from 1992-2009, we identified 28,854 men with prostate cancer, 5462 patients with bladder cancer, and 14,379 patients with renal cell carcinoma who underwent radical prostatectomy (RP), radical cystectomy (RC), or radical (RN) or partial nephrectomy (PN) as primary therapy...
June 2015: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/25189575/mirna-and-cancer-computational-and-experimental-approaches
#14
EDITORIAL
Yusuf Tutar
Human genome sequencing was started to solve four letter algorithm of the genome to understand the complex nature of human metabolism. However, after completion of Human Genome Project many scientists realized that sequence information alone was not sufficient to solve the biochemical mechanism of the organism through classical approaches. Non-coding parts of the genome produce small conserved ribonucleic acids, miRNAs to control cellular and physiological processes [1, 2]. This breakthrough discovery directed researches to examine role of miRNA in cancer since miRNAs are involved in the development, cell differentiation, and regulation of cell cycle [3]...
2014: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25032142/pulmonary-and-chest-wall-metastasectomy-in-urogenital-tumors-a-single-center-experience-and-review-of-literature
#15
Seyd Hossein Fattahi Masoum, Behzad Feizzdeh Kerigh, Alireza Goreifi
BACKGROUND: Pulmonary metastases are often found in advanced malignancies. Urogenital malignancies originating from kidney, prostate, testes, and bladder all metastasize preferentially to the lungs. OBJECTIVES: This retrospective study aimed to evaluate the results of pulmonary and chest wall metastasectomy in patients with primary urogenital Tumors. PATIENTS AND METHODS: The patients who underwent pulmonary metastasectomy in Ghaem Hospital from 1996 to 2011 were examined...
May 2014: Nephro-urology Monthly
https://www.readbyqxmd.com/read/24923229/risk-of-subsequent-cancers-in-renal-cell-carcinoma-survivors-with-a-family-history
#16
Tianhui Chen, Mahdi Fallah, Kristina Sundquist, Hao Liu, Kari Hemminki
BACKGROUND: This study aimed at elucidating the effect of family history on the development of subsequent cancers in renal cell carcinoma (RCC) survivors and aimed at assessing whether the interactions between risks of subsequent cancers in RCC survivors and familial risk of subsequent cancer are additive or multiplicative interactions. METHODS: A population-based cohort (Swedish Family-Cancer Database) of 14,267 RCC patients diagnosed in 1990-2010 was followed for cancer incidence...
August 2014: European Journal of Cancer
https://www.readbyqxmd.com/read/24786097/a-novel-protein-is-lower-expressed-in-renal-cell-carcinoma
#17
Ruili Guan, Yongde Xu, Hongen Lei, Zhezhu Gao, Zhongcheng Xin, Yinglu Guo
Engrailed-2 (EN2) has been identified as a candidate oncogene in breast cancer and prostate cancer. It is usually recognized as a mainly nuclear staining in the cells. However, recent studies showed a cytoplasmic staining occurred in prostate cancer, bladder cancer and clear cell renal cell carcinoma. The inconsistency makes us confused. To clarify the localization and expression of EN2 in renal cell carcinoma, anti-EN2 antibody (ab28731) and anti-EN2 antibody (MAB2600) were used for immunohistochemistry (IHC) respectively...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24721941/urological-tumors-in-renal-transplantation
#18
REVIEW
X Tillou, A Doerfler
The aim of this paper was to review the risk and incidence of urological malignancies and the clinical characteristics and outcomes of renal transplant urological malignancies. Medline/PubMed from January 1980 to February 2013 was searched to identify all medical literature about native kidney, graft bladder and prostate cancers. Comparing to general population, risk of kidney cancer was found to be 7 to 10 times greater and most of them are incidental low-stage, low-grade tumors with a good prognosis. Open and laparoscopic radical nephrectomies without lymph nodes dissection were reported to be safe...
March 2014: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/24669268/inflammatory-myofibroblastic-tumor-of-the-urinary-bladder-in-a-patient-with-the-left-renal-cell-carcinoma-a-case-report
#19
Shuiqing Wu, LE Chen, Qi Wan, Lei Zhang, Xiaokun Zhao, Xiuying Tang
This case report describes an inflammatory tumor of the urinary bladder along with left renal cell carcinoma which occurred in a 73-year-old male with a narrowed orificium urethrae internum and severe hyperplasia of the prostate gland. A biopsy was not obtained prior to surgery. An inflammatory myofibroblastic tumor (IMT) of the urinary bladder is a rare benign lesion, particularly in the elderly. To the best of our knowledge, there are no studies concerning IMTs of the urinary bladder in patients with unilateral renal cell carcinoma...
April 2014: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24606483/difference-in-the-incidences-of-the-most-prevalent-urologic-cancers-from-2003-to-2009-in-iran
#20
Abbas Basiri, Nasser Shakhssalim, Niloofar Yahyapour Jalaly, Hamid Heidarian Miri, Elham Partovipour, Mohammad Hossein Panahi
BACKGROUND: Urological cancers represent a major public problem associated with high mortality and morbidity. The pattern of these cancers varies markedly according to era, region and ethnic groups, but increasing incidence trends overall makes focused epidemiological studies important. The aim of the present study was to assess the incidence of most prevalent urological cancers in Iran from 2003 to 2009. MATERIALS AND METHODS: The data for this study were obtained from the population-based Cancer Registry Center of the Iran Ministry of Health and Medical Education...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
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