Alejandro G Szmulewicz, Gonzalo Martínez-Alés, Roger Logan, Maria Ferrara, Christian Kelly, Diane Fredrikson, Juan Gago, Sarah Conderino, Covadonga M Díaz-Caneja, Joaquín Galvañ, Lorna Thorpe, Vinod Srihari, Lakshmi Yatham, Deepak K Sarpal, Ann K Shinn, Celso Arango, Dost Öngür, Miguel A Hernán, On Behalf Of The Fep-Causal Collaboration
Good adherence to antipsychotic therapy helps prevent relapses in First Episode Psychosis (FEP). We used data from the FEP-CAUSAL Collaboration, an international consortium of observational cohorts to emulate a target trial comparing antipsychotics with treatment discontinuation as the primary outcome. Other outcomes included all-cause hospitalization. We benchmarked our results to estimates from EUFEST, a randomized trial conducted in the 2000s. We included 1097 patients with a psychotic disorder and less than 2 years since psychosis onset...
April 3, 2024: American Journal of Epidemiology