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Antipsychotic agents

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https://www.readbyqxmd.com/read/29913190/neurochemical-changes-underlying-schizophrenia-related-behavior-in-a-modified-forced-swim-test-in-mice
#1
Monika Wożniak, Paulina Cieślik, Marcin Marciniak, Tomasz Lenda, Andrzej Pilc, Joanna M Wieronska
The modified forced swim test (MFST) has excellent predictive validity for investigating the antipsychotic activity of drugs, with particular emphasis on their activity toward negative symptoms of schizophrenia. However, its face and construct validity are less understood. Therefore, in the present study, some biochemical changes within GABAergic and serotonergic neurotransmission that could be related to observed MK-801-induced disturbances and the activity of compounds active at those neurotransmitters were investigated...
June 15, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29901770/serotonin-syndrome-in-obstetrics-a-case-report-and-review-of-management
#2
Capt Heisy B Asusta, Maj Erin Keyser, Patricia Dominguez, Marvin Miller
Serotonin syndrome (SS) is a life-threatening condition, usually precipitated by a combination of serotonergic agents. Data regarding the incidence and management of SS in obstetrics are limited. This study presents a case of SS provoked by an atypical antipsychotic in a second trimester, singleton gestation, and reviews the management of SS in an obstetric patient. We present a case of a schizophreniform, pregnant patient with a singleton gestation admitted to a community, military hospital for serotonin syndrome...
June 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29879874/use-of-academic-detailing-with-audit-and-feedback-to-improve-antipsychotic-pharmacotherapy
#3
Mary F Brunette, Robert O Cotes, Alexander de Nesnera, Gregory McHugo, Nino Dzebisashvili, Haiyi Xie, Stephen J Bartels
OBJECTIVE: Second-generation antipsychotics vary in their propensity to cause serious cardiometabolic side effects. In addition, use of two or more antipsychotics (polypharmacy) may lead to additive side effects and has not been shown to be consistently more effective than monotherapy. This study examined the use of academic detailing with audit and feedback to improve antipsychotic prescribing practices, including antipsychotic polypharmacy and utilization of medication with high or low risk of cardiometabolic side effects ("high risk" or "low risk," respectively)...
June 8, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29869820/how-complete-is-the-information-on-preadmission-psychotropic-medications-in-inpatients-with-dementia-a-comparison-of-hospital-medical-records-with-dispensing-data
#4
Federica Edith Pisa, Francesca Palese, Federico Romanese, Fabio Barbone, Giancarlo Logroscino, Oliver Riedel
OBJECTIVES: Reliable information on preadmission medications is essential for inpatients with dementia, but its quality has hardly been evaluated. We assessed the completeness of information and factors associated with incomplete recording. METHODS: We compared preadmission medications recorded in hospital electronic medical records (EMRs) with community-pharmacy dispensations in hospitalizations with discharge code for dementia at the University Hospital of Udine, Italy, 2012-2014...
June 5, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29863695/-the-features-of-psychopharmacotherapy-of-depressive-states-with-panic-attacks
#5
N N Ivanets, M A Kinkulkina, K M Tartynskiy, G L Krenkel
AIM: To develop therapeutic programs for treatment of depression with panic attacks on the basis of their clinical and psychopathological features. MATERIAL AND METHODS: A total of 100 in- and outpatients, aged from 18 to 60 years, with depression of mild and moderate severity with panic attacks were studied. The investigation was carried out using clinical, psychopathological and psychometric (the Atypical Depression Diagnostic Scale (ADDS), the Montgomery-Asberg Depression Rating Scales (MADRS), and the Sheehan Anxiety Rating Scale (ShARS)) methods...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29859379/increased-risk-of-dementia-in-patients-with-schizophrenia-a-population-based-cohort-study-in-taiwan
#6
Ching-En Lin, Chi-Hsiang Chung, Li-Fen Chen, Mei-Ju Chi
BACKGROUND: The extent to which schizophrenia is associated with the risk of all-cause dementia is controversial. This study investigated the risk of dementia by type in patients with schizophrenia. METHODS: Data were collected from the Taiwanese National Health Insurance Database 2005 and analyzed using multivariate Cox proportional hazard regression models to determine the effect of schizophrenia on the dementia risk after adjusting for demographic characteristics, comorbidities, and medications...
May 30, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29858836/correction-to-long-acting-injectable-second-generation-antipsychotics-an-update-and-comparison-between-agents
#7
Michael W Jann, Scott R Penzak
1. In Page 244, under General Pharmacokinetic Principles, Column 1-the following sentence should come after reference 21.
June 2, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29851709/sustained-impairment-of-lurasidone-clearance-after-discontinuation-of-posaconazole-impact-of-obesity-and-implications-for-patient-safety
#8
David J Greenblatt, Jerold S Harmatz, Michael J Ryan, Christina R Chow
PURPOSE/BACKGROUND: The antipsychotic agent lurasidone (Latuda®) is metabolized by Cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors (such as ketoconazole, posaconazole, and ritonavir) is contraindicated due to the risk of sedation and movement disorders from high levels of lurasidone. This study evaluated the time-course of recovery from the posaconazole drug interaction, and the effect of obesity on the recovery process. METHODS/PROCEDURES: Healthy normal-weight volunteers (n = 11, mean body mass index, BMI, = 23...
May 30, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29851193/parenteral-antipsychotic-choice-and-its-association-with-ed-length-of-stay-for-acute-agitation-secondary-to-alcohol-intoxication
#9
Jon B Cole, Lauren R Klein, Marc L Martel
BACKGROUND: Acute agitation secondary to alcohol intoxication frequently requires parenteral sedatives for patient and caregiver safety. Antipsychotics play a prominent role, however no consensus exists regarding the ideal agent. One important consideration when evaluating the choice of antipsychotic is its association with ED length of stay (LOS). OBJECTIVES: We sought to determine the median ED LOS for patients receiving a single parenteral dose of an antipsychotic for acute agitation secondary to alcohol intoxication in an urban level 1 trauma center...
May 31, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29803327/-indirect-and-mixed-mechanisms-of-action-in-toxic-myopathies
#10
REVIEW
A Khelfi, M Azzouz, R Abtroun, M Reggabi, B Alamir
Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Some toxins from animals, plants or micro-organisms are potent myotoxic agents, which can lead to fatal complications. Respiratory arrest and rhabdomyolysis are often referred to as the ultimate complications of these pathologies...
May 23, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29803209/antipsychotics-in-hyperthyroid-related-psychosis-case-report-and-systematic-review
#11
Danielle Golub, Victor Rodack
OBJECTIVES: Hyperthyroidism has been associated with relatively rare presentations of psychotic symptoms. We report an example of the successful use of antipsychotics to manage psychotic symptoms in hyperthyroid-related psychosis. Furthermore, we systematically describe the available literature on the use of antipsychotics in this setting to determine the associated relative efficacies of the various antipsychotic agents. METHODS: Presentation of a case of hyperthyroid-related psychosis treated with an antipsychotic agent followed by a systematic review of all similar cases: PubMed, Ovid MEDLINE and PMC were searched for articles published between 1960 and 2017 that report on the use of specific antipsychotics in the management of hyperthyroid-related psychosis...
March 27, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29796151/2016-annual-report-of-the-university-of-kansas-health-system-poison-control-center
#12
Stephen L Thornton, Lisa Oller, Doyle M Coons
Introduction: This is the 2016 Annual Report of the University of Kansas Health System Poison Control Center (PCC). The PCC is one of 55 certified poison control centers in the United States and serves the state of Kansas 24-hours a day, 365 days a year, with certified specialists in poison information and medical toxicologists. The PCC receives calls from the public, law enforcement, health care professionals, and public health agencies. All calls to the PCC are recorded electronically in the Toxicall® data management system and uploaded in near real-time to the National Poison Data System (NPDS), which is the data repository for all poison control centers in the United States...
May 2018: Kansas journal of medicine
https://www.readbyqxmd.com/read/29790360/-current-and-future-pharmacotherapy-of-severe-psychiatric-disorders
#13
Eva Češková
Despite of tremendous development in CNS research, current treatment is suboptimal especially in severe mental disorders. In medicine, there are two main methods of improving the healthcare provided: seeking new treatment procedures and perfecting (optimizing) the existing ones. Optimization of treatment includes not only practical tools such as therapeutic drug monitoring, but also implementation of general trends into the clinical practice. New pharmacological options include drugs aimed at other than monoaminergic systems and old drugs used before the psychopharmacological era...
2018: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29767640/burden-of-exposure-to-potential-interactions-between-antiretroviral-and-non-antiretroviral-medications-in-a-population-of-hiv-positive-patients-aged-50-years-or-older
#14
Alice Ranzani, Letizia Oreni, Massimiliano Agrò, Lorena van den Bogaart, Laura Milazzo, Andrea Giacomelli, Dario Cattaneo, Cristina Gervasoni, Anna Lisa Ridolfo
BACKGROUND: As HIV-infected patients aged 50 years or older are at increased risk of comorbidities and multidrug treatments, we examined their exposure to the potential drug-drug interactions (PDDIs) of antiretroviral (ARV) and other medications. METHODS: This cross-sectional study involved the patients aged 50 years or older receiving ARV and non-ARV medications at our clinic. PDDIs were identified using the University of Liverpool HIV Drug Interaction Checker...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29761577/polypharmacy-and-psychotropic-drug-loading-in-patients-with-schizophrenia-in-asian-countries-the-reap-ap4-study
#15
Shu-Yu Yang, Lian-Yu Chen, Eunice Najoan, Roy Abraham Kallivayalil, Kittisak Viboonma, Ruzita Jamaluddin, Afzal Javed, Duong Thi Quynh Hoa, Hitoshi Iida, Kang Sim, Thiha Swe, Yan-Ling He, Yongchon Park, Helal Uddin Ahmed, Angelo De Alwis, Helen Fung-Kum Chiu, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Naotaka Shinfuku, Shih-Ku Lin
AIM: The aim of the present study was to survey the prevalence of antipsychotic polypharmacy and combined medication use across 15 Asian countries and areas in 2016. METHODS: By using the results from the fourth survey of Research on Asian Prescription Patterns on antipsychotics (REAP-AP4), the rates of polypharmacy and combined medication use in each country were analyzed. Daily medications prescribed for the treatment of inpatients or outpatients with schizophrenia, including antipsychotics, mood stabilizers, anxiolytics, hypnotics, and antiparkinson agents, were collected...
May 14, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29747564/reduse-reducing-antipsychotic-and-benzodiazepine-prescribing-in-residential-aged-care-facilities
#16
Juanita L Westbury, Peter Gee, Tristan Ling, Donnamay T Brown, Katherine H Franks, Ivan Bindoff, Aidan Bindoff, Gregory M Peterson
OBJECTIVE: To assess the impact of a multi-strategic, interdisciplinary intervention on antipsychotic and benzodiazepine prescribing in residential aged care facilities (RACFs). Design, setting: Prospective, longitudinal intervention in Australian RACFs, April 2014 - March 2016. PARTICIPANTS: 150 RACFs (with 12 157 residents) comprised the main participant group; two further groups were consultant pharmacists (staff education) and community pharmacies (prescribing data)...
May 14, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29742478/autoimmune-phenotypes-in-schizophrenia-reveal-novel-treatment-targets
#17
REVIEW
Emily G Severance, Faith B Dickerson, Robert H Yolken
Typical and atypical antipsychotics are the first-line treatments for schizophrenia, but these classes of drugs are not universally effective, and they can have serious side effects that impact compliance. Antipsychotic drugs generally target the dopamine pathways with some variation. As research of schizophrenia pathophysiology has shifted away from a strictly dopamine-centric focus, the development of new pharmacotherapies has waned. A field of inquiry with centuries-old roots is gaining traction in psychiatric research circles and may represent a new frontier for drug discovery in schizophrenia...
May 6, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29738426/pharmacological-treatment-of-sexual-offenders-in-german-outpatient-treatment-centers
#18
Daniel Turner, Priscilla Gregório Hertz, Julia Sauter, Peer Briken, Martin Rettenberger
In Germany, depending on a sexual offender's culpability and the severity of the offence, he/she can be placed either in the forensic-psychiatric or the correctional system. Numbers related to the pharmacological treatment of sexual offenders for the correctional system are missing so far. In sexual offenders, the pharmacological treatment of paraphilic disorders is of special importance. The present study aimed at assessing the prevalence of pharmacological sexual offender treatment in German outpatient treatment centers supervising mainly clients from the correctional sector...
May 4, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29732913/augmentation-strategies-for-clozapine-refractory-schizophrenia-a-systematic-review-and-meta-analysis
#19
Dan J Siskind, Michael Lee, Arul Ravindran, Qichen Zhang, Evelyn Ma, Balaji Motamarri, Steve Kisely
BACKGROUND: Although clozapine is the most effective medication for treatment refractory schizophrenia, only 40% of people will meet response criteria. We therefore undertook a systematic review and meta-analysis of global literature on clozapine augmentation strategies. METHODS: We systematically reviewed PubMed, PsycInfo, Embase, Cochrane Database, Chinese Biomedical Literature Service System and China Knowledge Resource Integrated Database for randomised control trials of augmentation strategies for clozapine resistant schizophrenia...
May 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29713098/successful-management-of-psychotropics-induced-stuttering-priapism-with-pseudoephedrine-in-a-patient-with-schizophrenia
#20
Srinagesh Mannekote Thippaiah, Soumya Nagaraja, Badari Birur, Ananda Pandurangi
Stuttering Priapism is a recurrent, persistent penile erection in the absence of sexual desire due to altered genital hemodynamics, affecting the arterial component (high flow, non-ischemic) or the veno-occlusive mechanism (low flow, ischemic). Both typical and atypical antipsychotics increase the risk for priapism with greater implications in typicals than atypicals. Prompt recognition and treatment are important as 40% to 50% of patients with stuttering priapism may develop an erectile dysfunction if left untreated...
February 5, 2018: Psychopharmacology Bulletin
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