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Jennifer M Noto, Abha Chopra, John T Loh, Judith Romero-Gallo, M Blanca Piazuelo, Mark Watson, Shay Leary, Amber C Beckett, Keith T Wilson, Timothy L Cover, Simon Mallal, Dawn A Israel, Richard M Peek
OBJECTIVE: Helicobacter pylori is the strongest risk factor for gastric cancer; however, the majority of infected individuals do not develop disease. Pathological outcomes are mediated by complex interactions among bacterial, host and environmental constituents, and two dietary factors linked with gastric cancer risk are iron deficiency and high salt. We hypothesised that prolonged adaptation of H. pylori to in vivo carcinogenic microenvironments results in genetic modification important for disease...
September 18, 2017: Gut
Mian Wang, Garima Bhardwaj, Thomas J Webster
Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth...
2017: International Journal of Nanomedicine
Wei Zhou, Wenpeng Zhang, Yikun Liu, Xinhong Yu, Zilin Chen
Capillary electrophoresis-mass spectrometry (CE-MS) is a hyphenated technique that combines the advantages like low sample consumption, high separation efficiency, short analytical time in CE and high sensitivity, powerful molecular structure elucidation in MS. Polyimide-coated fused silica capillary has become the most dominant capillary for CE, but it suffers from swelling and aminolysis of polyimide coating when treated with organic solvents and alkaline buffer in the CE-MS interface in which the polyimide coating at the end of the capillary is exposed to the solution, and this phenomenon can result in current instability, irregular electrospray and clogging at outlet after prolonged use...
September 22, 2017: Analytica Chimica Acta
Andreas Dominik Schwitalla, Tycho Zimmermann, Tobias Spintig, Mohamed Abou-Emara, Justus Lackmann, Wolf-Dieter Müller, Alireza Houshmand
Frequent reports attest to the various advantages of tapered implant/abutment interfaces (IAIs) compared to other types of interfaces. For this reason, a conical IAI was designed as part of the development of a PEEK (polyetheretherketone)-based dental implant. This IAI is equipped with an apically displaced anti-rotation lock with minimal space requirements in the form of an internal spline. The objective of this study was the determination of the average insertion torque (IT) at failure of this design, so as to determine its suitability for immediate loading, which requires a minimum IT of 32Ncm...
September 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
James C Blankenship
Patients rate the downsides of bare metal stents (higher restenosis rates) as being of similar magnitude to the downsides of drug eluting stents (longer dual anti-platelet therapy). Patient preferences regarding choice of bare metal versus drug eluting stents should be elicited before coronary stenting. This article does not study actual patient preferences for stent type. Future studies should assess how personalized discussions of trade-offs of stent types affect patient preferences.
September 1, 2017: Catheterization and Cardiovascular Interventions
Takeshi Yabutsuka, Keito Fukushima, Tomoko Hiruta, Shigeomi Takai, Takeshi Yao
When bioinert substrates with fine-sized pores are immersed in a simulated body fluid (SBF) and the pH value or the temperature is increased, fine particles of calcium phosphate, which the authors denoted as 'precursor of apatite' (PrA), are formed in the pores. By this method, hydroxyapatite formation ability can be provided to various kinds of bioinert materials. In this study, the authors studied fabrication methods of bioactive PEEK by using the above-mentioned process. First, the fine-sized pores were formed on the surface of the PEEK substrate by H2SO4 treatment...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Takayoshi Shimizu, Shunsuke Fujibayashi, Seiji Yamaguchi, Bungo Otsuki, Yaichiro Okuzu, Tomiharu Matsushita, Tadashi Kokubo, Shuichi Matsuda
BACKGROUND: Polyetheretherketone (PEEK) is a widely accepted biomaterial, especially in the field of spinal surgery. However, PEEK is not able to directly integrate with bone tissue, due to its bioinertness. To overcome this drawback, various studies have described surface coating approaches aimed at increasing the bioactivity of PEEK surfaces. Among those, it has been shown that the recently developed sol-gel TiO2 coating could provide PEEK with the ability to bond with bone tissue in vivo without the use of a bone graft...
2017: PloS One
Su Hun Lee, Jun Seok Lee, Soon Ki Sung, Dong Wuk Son, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Preoperative parameters including the T1 slope (T1S) and C2-C7 sagittal vertical axis (SVA) have been recognized as predictors of kyphosis after laminoplasty, which is accompanied by posterior neck muscle damage. The importance of preoperative parameters has been under-estimated in anterior cervical discectomy and fusion (ACDF) because there is no posterior neck muscle damage. We aimed to determine whether postoperative subsidence and pseudarthrosis could be predicted according to specific parameters on preoperative plain radiographs...
September 2017: Journal of Korean Neurosurgical Society
T N Augustine, K Pather, T Dix-Peek, R Duarte
BACKGROUND: Cancer is associated with hypercoagulability, with therapies including chemotherapy, radiation therapy, surgery and hormone-therapy linked to an increased risk of thrombotic complications. Notwithstanding the contribution of other haematological processes and components, platelets are implicated in contributing to a hypercoagulable state, with breast cancer patients receiving Tamoxifen treatment at a greater risk for thrombotic complications. METHOD: MCF-7 and T47D breast cancer cells were cultured under standard conditions, followed by treatment with 2uM Tamoxifen for 24 hours and co-cultured with whole blood (WB) for 2...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
Erzhu Yang, Liangliang Cao, Guowang Zhang, Xiaofeng Lian, Jianguang Xu
OBJECTIVE: To explore the safety and efficacy of transpseudarthrosis osteotomy with interbody fusion in the treatment of Ankylosing Spondylitis (AS) patients with kyphotic spinal pseudarthrosis by a single posterior approach. METHODS: Twelve consecutive patients with spinal pseudarthrosis underwent transpseudarthrosis osteotomy and interbody fusion with a polyetheretherketone (PEEK) cage by a single posterior approach. The operative time, intraoperative blood loss, and complications were recorded...
2017: BioMed Research International
Rafael Augusto Castro Santiago Brandão, Warley Carvalho da Silva Martins, Aluízio Augusto Arantes, Sebastião Nataniel Silva Gusmão, Gilles Perrin, Cédric Barrey
BACKGROUND: Titanium and polyetheretherketone (PEEK) implants have been used in spinal surgery with low rejection rates. Compared to titanium, PEEK has many advantages, including a density more similar to that of bone, radiolucency, and a lack of artifacts in computed tomography (CT) and magnetic resonance imaging (MRI). In this study, we evaluated the effectiveness of PEEK cages as an alternative to titanium for bone fusion after fractures of the thoracolumbar spine. We also propose a classification to the impaction index...
2017: Surgical Neurology International
Panagiotis Zoidis, Eleonora Bakiri, Ioannis Papathanasiou, Anastasia Zappi
This case report describes the fabrication of 3 single crowns for a patient with weakened abutment teeth. The patient exhibited nocturnal bruxism and clenching but refused to use an occlusal appliance. The abutment teeth were endodontically treated and presented with loss of tooth structure and thin axial walls. The patient was seeking a metal-free restoration, and all-ceramic restorations were contraindicated because of the potential for abrasion of the opposing teeth and direct force transmission to the weak abutment teeth...
September 2017: General Dentistry
Ali Fahir Ozer, Tunc Oktenoglu, Emrah Egemen, Mehdi Sasani, Atilla Yilmaz, Deniz Ufuk Erbulut, Onur Yaman, Tuncer Suzer
BACKGROUND: This study compares the clinical and radiological results of three most commonly used dynamic stabilization systems in the field of orthopedic surgery. METHODS: A total of 71 patients underwent single-level posterior transpedicular dynamic stabilization between 2011 and 2014 due to lumbar degenerative disc disease. Three different dynamic systems used include: (1) the Dynesys system; (2) a dynamic screw with a PEEK rod; and (3) a full dynamic system (a dynamic screw with a dynamic rod; BalanC)...
September 2017: Clinics in Orthopedic Surgery
Kevin Niall Peek, Michael Gillham
AIMS: The rate of medical emergency team (MET) calling among post-cardiac surgery patients is unknown. We set out to determine what the call frequency would be if MET activation occurred in every instance that the early warning score (EWS) breached our local threshold, what the outcome was for these patients and what the calling rate might be if the proposed New Zealand EWS (NZEWS) system was implemented with 100% adherence. METHODS: The clinical records of 400 consecutive post-cardiac surgery patients were examined...
September 1, 2017: New Zealand Medical Journal
Muhammad Atiq Ur Rehman, Sara Ferraris, Wolfgang Goldmann, Sergio Perero, Fatih Erdem Bastan, Qaisar Nawaz, G Gautier di Confiengo, Monica Ferraris, Aldo R Boccaccini
Bioactive and antibacterial coatings on stainless steel substrates were developed and characterized in this study. Silver nanocluster-silica composite coatings of 60-150 nm thickness were deposited using radio frequency (RF) co-sputtering on PEEK/bioactive glass (BG) layers (of 80-90 µm thickness) which had been electrophoretically deposited onto stainless steel. Two sputtering conditions were used by varying the deposition time (15 min and 40 min); the resulting microstructure, composition, adhesion strength, in-vitro bioactivity and antibacterial activity were investigated...
August 31, 2017: ACS Applied Materials & Interfaces
Jacqueline A Overton, Dylan F Cooke, Adam B Goldring, Steven A Lucero, Conor Weatherford, Gregg H Recanzone
Traditionally, head fixation devices and recording cylinders have been implanted in non-human primates (NHP) using dental acrylic, in spite of several shortcomings associated with acrylic. The use of more biocompatible materials such as titanium and PEEK is becoming more prevalent in NHP research. We describe a cost-effective set of procedures that maximizes the integration of headposts and recording cylinders with the animal's tissues while reducing surgery time. Nine rhesus monkeys were implanted with titanium headposts and one of these was also implanted with a recording chamber...
August 30, 2017: Journal of Neurophysiology
McL Peek, M Ahmed, J Scudder, R Baker, P Charalampoudis, S E Pinder, M Douek
Abstact Background: High intensity focused ultrasound (HIFU) is a non-invasive ablative technique utilising the application of high frequency ultrasound (US) pressure waves to cause tissue necrosis. This emerging technology is currently limited by prolonged treatment times. The aim of the HIFU-F trial was to perform circumferential HIFU treatment as a means of shortening treatment times. METHODS: A prospective trial was set up to treat 50 consecutive patients ≥18 years of age. Eligible patients possessed symptomatic fibroadenomata, visible on US...
August 30, 2017: International Journal of Hyperthermia
Stefan Bubik, Michael Payer, Gerwin Arnetzl, Heike Kaltenegger, Andreas Leithner, Arnold Klampfl, Birgit Lohberger
OBJECTIVES: To prove the biocompatibility of biomaterials applied in biomedical devices, in vitro testing is crucial to render a material fit for medical application. The material of choice for dental implants is commercially pure titanium (cp-Ti), while other materials such as zirconia and polyetheretherketone (PEEK) are considered highly promising due to their functional and esthetic properties. The aim of this study was to determine whether PEEK with defined mean surface roughness and composition could achieve results equal to titanium or zirconia...
2017: International Journal of Computerized Dentistry
Juanjuan Feng, Xiuqin Wang, Yu Tian, Yanan Bu, Chuannan Luo, Min Sun
Carbon fibers (CFs) were functionalized with graphene oxide (GO) by an electrophoretic deposition (EPD) method for in-tube solid-phase microextraction (SPME). GO-CFs were filled into a poly(ether ether ketone) (PEEK) tube to obtain a fibers-in-tube SPME device, which was connected with high performance liquid chromatography (HPLC) equipment to build online SPME-HPLC system. Compared with CFs, GO-CFs presented obviously better extraction performance, due to excellent adsorption property and large surface area of GO...
July 29, 2017: Journal of Chromatography. A
Yanan Bu, Juanjuan Feng, Yu Tian, Xiuqin Wang, Min Sun, Chuannan Luo
Aerogels have received considerable attentions because of its porous, high specific surface, unique properties and environmental friendliness. In this work, an organically modified silica aerogel was functionalized on the basalt fibers (BFs) and filled into a poly(ether ether ketone) (PEEK) tube, which was coupled with high performance liquid chromatography (HPLC) for in-tube solid-phase microextraction (IT-SPME). The aerogel was characterized by scanning electron microscopy (SEM) and fourier transform infrared spectrometry (FT-IR)...
July 24, 2017: Journal of Chromatography. A
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