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https://www.readbyqxmd.com/read/28209611/genetic-manipulation-of-helicobacter-pylori-virulence-function-by-host-carcinogenic-phenotypes
#1
Giovanni Suarez, Judith Romero-Gallo, Johanna C Sierra, M Blanca Piazuelo, Uma Krishna, Martin Alonso Gomez, Keith T Wilson, Richard M Peek
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, yet only a minority of infected persons ever develop this malignancy. One cancer-linked locus is the cag type 4 secretion system (cagT4SS), which translocates an oncoprotein into host cells. A structural component of the cagT4SS is CagY, which become rapidly altered during in vivo adaptation in mice and rhesus monkeys, rendering the cagT4SS nonfunctional; however, these models rarely develop gastric cancer. We previously demonstrated that the H...
February 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28207716/long-live-hubble
#2
Katie Peek
No abstract text is available yet for this article.
February 14, 2017: Scientific American
https://www.readbyqxmd.com/read/28193714/contributors-to-pedestrian-distraction-and-risky-behaviours-during-road-crossings-in-romania
#3
Cara Hamann, Diana Dulf, Erika Baragan-Andrada, Morgan Price, Corinne Peek-Asa
OBJECTIVE: Pedestrian fatalities due to collisions with motor vehicles are a large public health problem in Romania, ranking them among the highest in Eastern Europe. The purpose of this study was to gain a better understanding of crash factors by examining how roadway and environmental characteristics contribute to pedestrian distraction and risky behaviours at pedestrian MVC (PMVC) locations in Cluj County, Romania. METHODS: A sample of PMVC locations was selected from the 2010 Cluj County police reported crash database for on-site examination...
February 13, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28191593/learning-from-a-contemporary-history-of-immunology
#4
REVIEW
Melvin Cohn
This essay is a selected aspect of the history of contemporary immunology seen from a "what can we learn" point of view. It is limited to the ideas and experiments from which we might draw a take-home message. The emphasis is on the convoluted pathway that was actually used by immunologists to arrive at understanding compared to the direct pathway that could have been used given the knowledge at that time. It takes the reader through the instructionist era of the 1940s to the present by stressing the elements of thinking most conducive to the arrival at a default understanding of the intact immune system...
February 13, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28187368/outcomes-of-autograft-alone-versus-peek-autograft-interbody-fusion-in-the-treatment-of-adult-lumbar-isthmic-spondylolisthesis
#5
Gang Wang, Dunfu Han, Zhenglin Cao, Honggang Guan, Tianhang Xuan
OBJECTIVES: Bone resulting from a complete resection of the posterior arch can be cut into an autograft bone that contains the facet joint structure and morselised bone for interbody fusion. However, whether a strut autograft that contains this trimmed facet joint can produce the same clinical and radiographic outcomes as a cage for interbody fusion remains unclear. The aim of this study was to compare the outcomes of a local facet joint autograft alone to those of polyetheretherketone (PEEK)+autograft for posterior lumbar interbody fusion (PLIF) in the treatment of adult isthmic spondylolisthesis...
January 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28185678/in-vitro-fatigue-and-fracture-testing-of-cad-cam-materials-in-implant-supported-molar-crowns
#6
Verena Preis, Sebastian Hahnel, Michael Behr, Laila Bein, Martin Rosentritt
OBJECTIVE: To investigate the fatigue and fracture resistance of different CAD/CAM-materials as implant- or tooth-supported molar crowns with respect to the clinical procedure (screwed/bonded restoration). METHODS: 168 crowns were fabricated from different CAD/CAM-materials (n=8/material): ZLS (zirconia-reinforced lithium silicate ceramic; Suprinity, Vita-Zahnfabrik), COB (composite; Brilliant Crios, Coltene), COL (composite; Lava Ultimate, 3M Espe), PMV/PPV (polyether ether ketone (PEEK)+milled composite veneer/composite paste veneer; BioHPP+HIPC veneer/Crealign veneer, Bredent), COH (composite; Block HC, Shofu), and ZIR (zirconia; IPS e...
February 6, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28183629/mechanical-properties-and-in-vivo-study-of-modified-hydroxyapatite-polyetheretherketone-biocomposites
#7
Rui Ma, Qiankuan Li, Lin Wang, Xianghua Zhang, Lin Fang, Zhongkuan Luo, Bai Xue, Lei Ma
Polyether ether ketone (PEEK) has received much attention for its excellent mechanical properties and biocompatibility. Here, the silane coupling agent KH560 [γ-(2,3-epoxypropoxy)propyltrimethoxysilane] is used for graft modification of bioactive HA (hydroxyapatite) particles and for preparing HA/PEEK composites via a hot-press molding method. The prepared HA/PEEK composites were tested for their mechanical properties with SEM (scanning electron microscopy), infrared spectroscopy, and thermo-analysis. The results show that silane coupling KH-560 modifies HA successfully and that the tensile strengths of HA/PEEK and m-HA/PEEK composites indicate an increasing and then a decreasing tendency with increasing HA contents...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28176615/identification-by-next-generation-sequencing-of-aichivirus-b-in-a-calf-with-enterocolitis-and-neurologic-signs
#8
Ana S D Moreira, Sarah M Raabis, Melissa E Graham, Jennifer M Dreyfus, Samuel D Sibley, Jennifer A Godhardt-Cooper, Kathy L Toohey-Kurth, Tony L Goldberg, Simon F Peek
An 11-d-old Holstein bull calf was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin-Madison because of a 4-d history of diarrhea and persistent low-grade fever. Initial diagnosis was enteritis caused by Cryptosporidium and rotavirus. During hospitalization, the calf became stuporous and was only responsive to noxious stimuli, with hypotonia of all 4 limbs, tail, head, and neck. A cerebrospinal fluid analysis revealed xanthochromia, with marked lymphocytic pleocytosis, which was suggestive of viral meningitis and/or encephalitis...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28174724/not-all-mice-are-the-same-standardization-of-animal-research-data-presentation
#9
EDITORIAL
M Bishr Omary, David E Cohen, Emad M El-Omar, Rajiv Jalan, Malcolm J Low, Michael H Nathanson, Richard M Peek, Jerrold R Turner
No abstract text is available yet for this article.
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28172940/p559-treatment-goals-in-ibd-a-perspective-from-patients-and-their-partners
#10
N Peek-Kuijt, M Aantjes, M Verwey, A van der Meulen-de Jong, P Maljaars
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28162164/-repair-mechanisms-of-the-wounds-with-exposed-bone-structures-using-an-artificial-dermis
#11
X Chen, C Wang, C Zhang, X Huang, H S Cao
Objective: To investigate the repair mechanisms of the wounds with bone exposed by artificial dermis transplantation. Methods: Seventy two rabbits were randomly divided into 3 groups of 24 rabbits, the wound model was made on the top of head. In the skin defect group (SD group), skin was removed and skull periosteum was retained. In the periosteal defect group (PD group), the skin and skull periosteum were both removed, and the skull was exposed. In the skull burn group (SB group), after the periosteum was removed, the exposed skull bone was burned out with electric iron to cause skull surface necrosis, then the artificial dermis transplantation were performed in each group...
January 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28160738/on-the-mechanical-behaviour-of-peek-and-ha-cranial-implants-under-impact-loading
#12
D Garcia-Gonzalez, J Jayamohan, S N Sotiropoulos, S-H Yoon, J Cook, C R Siviour, A Arias, A Jérusalem
The human head can be subjected to numerous impact loadings such as those produced by a fall or during sport activities. These accidents can result in skull fracture and in some complex cases, part of the skull may need to be replaced by a biomedical implant. Even when the skull is not damaged, such accidents can result in brain swelling treated by decompressive craniectomy. Usually, after recovery, the part of the skull that has been removed is replaced by a prosthesis. In such situations, a computational tool able to analyse the choice of prosthesis material depending on the patient's specific activity has the potential to be extremely useful for clinicians...
January 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28159450/laser-fabrication-of-electrical-feedthroughs-in-polymer-encapsulations-for-active-implantable-medical-devices
#13
Zara Gough, Cedric Chaminade, Philip Barclay-Monteith, Annukka Kallinen, Wenwen Lei, Rajesh Ganesan, John Grace, David R McKenzie
Hermetic electrical feedthroughs are essential for safe and functional active implantable biomedical devices and for a wide range of other applications such as batteries, supercapacitors, OLEDs and solar cells. Ceramics and metals have previously been the materials of choice for encapsulations, while polymers have advantages of ease of mass production and end user compatibility. We demonstrate a laser sealing technology that gives hermetic, mechanically strong feedthroughs with low electrical resistance in a polyetheretherketone (PEEK) encapsulation...
January 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28156204/a-rare-case-of-pharyngeal-perforation-and-expectoration-of-an-entire-anterior-cervical-fixation-construct
#14
Syed A Quadri, John Capua, Vivek Ramakrishnan, Raed Sweiss, Marc Cabanne, Jerry Noel, Brian Fiani, Javed Siddiqi
Anterior cervical discectomy and fusion (ACDF) is a very common surgery performed globally. Although a few cases of expectorating screws or extrusion of screws into the gastrointestinal tract through esophageal perforations have previously been reported, there has not been a case reporting pharyngeal perforation and entire cervical construct extrusion in the literature to date. In this report the authors present the first case involving the extrusion of an entire cervical construct via a tear in the posterior pharyngeal wall...
February 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28156062/an-observational-study-of-australian-private-practice-physiotherapy-consultations-to-explore-the-prescription-of-self-management-strategies
#15
Kerry Peek, Mariko Carey, Lisa Mackenzie, Robert Sanson-Fisher
OBJECTIVE: The aim of the study was to explore the types of self-management strategies prescribed; the number of strategies and the overall length of time allocated to self-management prescription, by consultation type and by injury location, in physiotherapy consultations. METHODS: A cross-sectional, observational study of 113 physiotherapist-patient consultations was undertaken. Regression analyses were used to determine whether consultation type and injury location were associated with the number of strategies prescribed and the length/fraction of time spent on self-management...
February 3, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28153602/comparison-of-allograft-and-polyetheretherketone-peek-cage-subsidence-rates-in-anterior-cervical-discectomy-and-fusion-acdf
#16
Sharon C Yson, Jonathan N Sembrano, Edward Rainier G Santos
Structural allografts and PEEK cages are commonly used interbody fusion devices in ACDF. The subsidence rates of these two spacers have not yet been directly compared. The primary aim of this study was to compare the subsidence rate of allograft and PEEK cage in ACDF. The secondary aim was to determine if the presence of subsidence affects the clinical outcome. We reviewed 67 cases (117 levels) of ACDF with either structural allograft or PEEK cages. There were 85 levels (48 cases) with PEEK and 32 levels (19 cases) with allograft spacers...
January 30, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28149944/a-peek-into-the-world-behind-the-submit-button
#17
EDITORIAL
Miranda A Paley
No abstract text is available yet for this article.
January 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28144820/a-preclinical-numerical-assessment-of-a-polyetheretherketone-femoral-component-in-total-knee-arthroplasty-during-gait
#18
Lennert de Ruiter, Dennis Janssen, Adam Briscoe, Nico Verdonschot
BACKGROUND: Conventional total knee replacement designs show high success rates but in the long term, the stiff metal components may affect bone quality of the distal femur. In this study we introduce an all-polymer total knee replacement device containing a PEEK femoral component on an UHMWPE tibial implant and study its mechanical integrity, fixation, and stress shielding of the periprosthetic femur. METHODS: The implant was analysed in finite element simulations of level gait, adopted from the ISO 14243-1 standard...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28134971/engineering-thermoplastics-for-additive-manufacturing-a-critical-perspective-with-experimental-evidence-to-support-functional-applications
#19
Gianluca Cicala, Alberta Latteri, Barbara Del Curto, Alessio Lo Russo, Giuseppe Recca, Silvia Farè
BACKGROUND: Among additive manufacturing techniques, the filament-based technique involves what is referred to as fused deposition modeling (FDM). FDM materials are currently limited to a selected number of polymers. The present study focused on investigating the potential of using high-end engineering polymers in FDM. In addition, a critical review of the materials available on the market compared with those studied here was completed. METHODS: Different engineering thermoplastics, ranging from industrial grade polycarbonates to novel polyetheretherketones (PEEKs), were processed by FDM...
January 28, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28131883/layer-by-layer-self-assembled-multilayers-on-peek-implants-improve-osseointegration-in-an-osteoporosis-rabbit-model
#20
Xilin Liu, Fei Han, Peng Zhao, Chao Lin, Xuejun Wen, Xiaojian Ye
This study aims to fabricate and deposit nanoscale multilayers on polyetheretherketone (PEEK) to improve cell adhesion and osseointegration. Bio-activated PEEK constructs were designed with prepared surface of different layers of polystyrene sulfonate (PSS) and polyallylamine hydrochloride (PAH) multilayers. Irregular morphology was found on the 5 and 10-layer PEEK surfaces, while "island-like" clusters were observed for 20-layer (20 L) multilayers. Besides, the 20 L PEEK showed more hydrophilic feature than native PEEK, and the surface contact angle reduced from 39...
January 25, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
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