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Philipp Marx, Wojciech Kowalczyk, Aydin Demircioglu, Gary Neil Brault, Hermann Wendt, Sharaf-Eldin Shehada, Konstantinos Tsagakis, Mohamed El Gabry, Heinz Jakob, Daniel Wendt
The aim of the present in vitro study was the evaluation of the fluid dynamical performance of the Carpentier-Edwards PERIMOUNT Magna Ease depending on the prosthetic size (21, 23, and 25 mm) and the cardiac output (3.6-6.4 L/min). A self-constructed flow channel in combination with particle image velocimetry (PIV) enabled precise results with high reproducibility, focus on maximal and local peek velocities, strain, and velocity gradients. These flow parameters allow insights into the generation of forces that act on blood cells and the aortic wall...
2018: BioMed Research International
Zhe Du, Shujun Wang, Bing Yue, Ying Wang, You Wang
T-cells, second only to macrophages, are often considered as the potential cells involved in debris-related failure of arthroplasty. Here, we assessed the effects of particulate wear debris on T-cells and inflammatory reactions. Blood samples from 25 donors were incubated with polyether-ether-ketone (PEEK) and cobalt-chromium-molybdenum (CoCrMo) particles generated by custom cryo-milling and pulverization. The T-cell phenotypes were assessed using immunostaining and flow cytometry. For the in vivo study, 0...
February 16, 2018: Oncotarget
Sven Hoppe, Christoph E Albers, Tarek Elfiky, Moritz C Deml, Helena Milavec, Sebastian F Bigdon, Lorin M Benneker
The aim of this study was to assess the performance of a new vacuum plasma sprayed (VPS) titanium-coated carbon/polyetheretherketone (PEEK) cage under first use clinical conditions. Forty-two patients who underwent a one or two segment transforaminal lumbar interbody fusion (TLIF) procedure with a new Ca/PEEK composite cage between 2012 and 2016 were retrospectively identified by an electronic patient chart review. Fusion rates (using X-ray), patient's satisfaction, and complications were followed up for two years...
March 14, 2018: Journal of Functional Biomaterials
Ashley H Noriea, Nicole Redmond, Rebekah A Weil, William A Curry, Monica E Peek, Lisa L Willett
No abstract text is available yet for this article.
March 2018: Family Medicine
Elizabeth L Tung, Kelly Boyd, Stacy Tessler Lindau, Monica E Peek
Neighborhood crime may be an important social determinant of health in many high-poverty, urban communities, yet little is known about its relationship with access to health-enabling resources. We recruited an address-based probability sample of 267 participants (ages ≥35 years) on Chicago's South Side between 2012 and 2013. Participants were queried about their perceptions of neighborhood safety and prior experiences of neighborhood crime. Survey data were paired to a comprehensive, directly-observed census of the built environment on the South Side of Chicago...
March 2018: Preventive Medicine Reports
Kerry Peek, Don Gatherer, Kyle J M Bennett, Job Fransen, Mark Watsford
The objective of this study was to investigate knee muscle strength characteristics in players from a high-level youth football Academy. In total, 110 players (aged 8-15 years) underwent muscle strength assessments carried out by a research physiotherapist using a computer-linked hand-held dynamometer. Results indicated that isometric hamstrings and quadriceps strength increased with age, whereas the isometric hamstring to quadriceps (H/Q) ratio decreased with age. A number of youth football players (n = 20; 18%; 95% CI: 11-27%) demonstrated isometric H/Q ratios of less than 0...
March 5, 2018: Research in Sports Medicine
Gilles Norotte, Carlos Barrios
OBJECTIVE: Recent improvements in cage designs with integral fixation and screw attachments have made stand-alone ALIF a viable option with several possible advantages. The aim of this study was to confirm the efficacy and safety of a PEEK cage filled with hydroxyapatite nanoparticles without adding a bone graft for stand-alone ALIF in the treatment of L5-S1 isolated degenerative disc discopathy (DDD). PATIENTS AND METHODS: Sixty-five patients who required surgery for DDD were evaluated...
January 31, 2018: Clinical Neurology and Neurosurgery
Xiuru Liu, Ru Jia, DouDou Zhang, Chaosheng Yuan, Chunguang Shao, Shiming Hong
By using a self-designed pressure-jump apparatus, we investigated the melt solidification behavior in rapid compression process for several kinds of materials, such as elementary sulfur, polymer polyether-ether-ketone (PEEK) and poly-ethylene-terephthalate (PET), alloy La<sub>68</sub>Al<sub>10</sub>Cu<sub>20</sub>Co<sub>2</sub> and Nd<sub>60</sub>Cu<sub>20</sub>Ni<sub>10</sub>Al<sub>10</sub>...
March 5, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Erik Hohmann
Subpectoral tenodesis is performed at the surgical neck of the humerus. In a cadaveric study, the insertion of a unicortical PEEK (polyether ether ketone) screw decreased the torsional load to failure (fracture) by 30% compared with intact control specimens but was similar to unicortical reaming without screw insertion. Placing the biceps tendon into the tunnel and securing it with a unicortical screw reduced the torsional load to failure by 20%. Whether these facts are significant is currently unknown, but the creation of a stress riser is a concern and may possibly result in surgical neck fractures...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Zhenjun Zhang, Hui Li, Guy R Fogel, Dingding Xiang, Zhenhua Liao, Weiqiang Liu
In lumbar interbody fusion, a porous additive manufactured (AM) cage can provide more desirable stiffness, and may be beneficial to bone ingrowth. The biomechanical influence of porous cages on stability, subsidence, and facet contact force has not been fully described. The aim of this study was to verify biomechanical effects of porous cages. Surgical finite element (FE) model of transforaminal lumbar interbody fusion (TLIF) was constructed. The partially porous (PP) cages and fully porous (FP) cages were applied...
February 23, 2018: Computers in Biology and Medicine
Richard A Lindtner, Rene Schmid, Thomas Nydegger, Marko Konschake, Werner Schmoelz
PURPOSE: Pedicle screw loosening is a common and significant complication after posterior spinal instrumentation, particularly in osteoporosis. Radiolucent carbon fiber-reinforced polyetheretherketone (CF/PEEK) pedicle screws have been developed recently to overcome drawbacks of conventional metallic screws, such as metal-induced imaging artifacts and interference with postoperative radiotherapy. Beyond radiolucency, CF/PEEK may also be advantageous over standard titanium in terms of pedicle screw loosening due to its unique material properties...
March 1, 2018: European Spine Journal
W R Walsh, M Pelletier, C Christou, J He, F Vizesi, S D Boden
BACKGROUND: Context: Increasing bone ongrowth and ingrowth of PEEK interbody fusion devices has the potential to improve clinical outcomes. PURPOSE: This study evaluated the in vivo response of promoting new bone growth and bone apposition with NM compared to PEEK alone in a cancellous implantation site with an empty aperture. STUDY DESIGN: This is a randomized control animal study METHODS: Implants and funding for this study were provided by SeaSpine (60,000 USD)...
February 26, 2018: Spine Journal: Official Journal of the North American Spine Society
Kirk McGilvray, Jeremiah Easley, Howard B Seim, Daniel Regan, Sigurd H Berven, Wellington K Hsu, Thomas E Mroz, Christian M Puttlitz
BACKGROUND CONTEXT: There is significant variability in the materials commonly used for interbody cages in spine surgery. It is theorized that 3-D printed interbody cages utilizing porous titanium material can provide more consistent bone ingrowth and biological fixation. PURPOSE: The purpose of this study was to provide an evidence-based approach to decision making regarding interbody materials for spinal fusion. STUDY DESIGN: Comparative animal study...
February 26, 2018: Spine Journal: Official Journal of the North American Spine Society
Jeko M Madjarov, Michael G Katz, Peter N Kane, Svetozar Madzharov, Francis Robicsek
PURPOSE: The surgical management of the patients with traumatic sternal fractures remains controversial. The aim of this study was to evaluate the effectiveness of an early surgical reconstruction of a displaced sternal fracture utilizing longitudinal rigid polymer fixation in the settings of an acute chest trauma. METHODS: To perform the sternal fixation, we utilized a longitudinal rigid plating system. The plate is made of polyether ether ketone (PEEK), an organic thermoplastic polymer...
February 27, 2018: Annals of Thoracic and Cardiovascular Surgery
Andrea C Gielen, Shannon Frattaroli, Keshia M Pollack, Corinne Peek-Asa, Jingzhen G Yang
BACKGROUND: In the decades since the landmark report-America Burning-was published in 1973, the number of home fire deaths has shrunk from >5500 per year to 2650 in 2015. This paper: (1) describes how science and practice in injury prevention and fire and life safety contributed to successful interventions, and (2) identifies emerging strategies and future opportunities to prevent home fire-related deaths. METHODS: The aims are addressed through the lens of population health research, with a focus on the work of selected Centers for Disease Control and Prevention-funded Injury Control Research Centers...
February 26, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Ehab Shiban, Moritz Nies, Johann Kogler, Lorenz Kogler, Pedro Ribeiro da Cunha, Bernhard Meyer, Jens Lehmberg
AIM: To correlate clinical and radiological outcome following one- and two-level anterior cervical discectomy and fusion (ACDF) with stand-alone polyetheretherketone (PEEK) cages filled with demineralized bone matrix (DBM). METHODS: We performed a retrospective review of a consecutive patient cohort with degenerative disc disease that underwent ACDF with stand-alone PEEK cages filled with demineralized bone matrix (DBM) between 2010 and 2013 with a minimum follow-up of 12 months...
February 26, 2018: Acta Neurochirurgica
Yongkun Xu, Huimin Qi, Guitao Li, Xueping Guo, Yong Wan, Ga Zhang
Polymer composites have a high potential for applications as tribo-materials exposed to sea water owing to their self-lubrication characteristic and high chemical stability. In the present work, tribological behaviors of polyetheretherketone (PEEK) composites rubbing with stainless steel in sea water were explored using a pin-on-disc tribometer integrated with a potentiostat for electrochemical control. It was demonstrated that further adding 5 vol% hexagonal boron nitride (h-BN) nanoparticles into PEEK reinforced with short carbon fibers (SCF) significantly enhanced the wear resistance...
February 13, 2018: Journal of Colloid and Interface Science
Iris Noordhoek, Marvyn T Koning, Wilco C H Jacobs, Carmen L A Vleggeert-Lankamp
BACKGROUND: The placement of intervertebral cages in anterior cervical discectomy (ACDF) supposedly maintains foraminal height. The most commonly reported cage-related complication is subsidence, although it is unknown whether a correlation between subsidence and clinical outcome exists. AIM: To assess the incidence and relevance of subsidence. METHODS: Literature searches were performed in PubMed, MEDLINE, Embase, Web of Science, COCHRANE, and CENTRAL...
February 21, 2018: Acta Neurochirurgica
Mona Tafreshi, Jyeswei Guan, Rebecca J Gorrell, Nicole Chew, Yue Xin, Virginie Deswaerte, Manfred Rohde, Roger J Daly, Richard M Peek, Brendan J Jenkins, Elizabeth M Davies, Terry Kwok
The Gram-negative bacterium, Helicobacter pylori , causes chronic gastritis, peptic ulcers, and gastric cancer in humans. Although the gastric epithelium is the primary site of H. pylori colonization, H. pylori can gain access to deeper tissues. Concurring with this notion, H. pylori has been found in the vicinity of endothelial cells in gastric submucosa. Endothelial cells play crucial roles in innate immune response, wound healing and tumorigenesis. This study examines the molecular mechanisms by which H...
2018: Frontiers in Cellular and Infection Microbiology
Amit Kumar, Wai Teng Yap, Soo Leong Foo, Teck Kheng Lee
The effects of the sterilization process have been studied on medical grade thermoplastic polyetheretherketone (PEEK). For a reusable medical device, material reliability is an important parameter to decide its lifetime, as it will be subjected to the continuous steam sterilization process. A spring nature, clip component was selected out of a newly designed medical device (patented) to perform this reliability study. This clip component was sterilized for a predetermined number of cycles (2, 4, 6, 8, 10, 20…100) at 121 °C for 30 min...
February 21, 2018: Bioengineering
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