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https://www.readbyqxmd.com/read/29351565/sumo-targeting-of-a-stress-tolerant-ulp1-sumo-protease
#1
Jennifer Peek, Catherine Harvey, Dreux Gray, Danny Rosenberg, Likhitha Kolla, Reuben Levy-Myers, Rui Yin, Jonathan L McMurry, Oliver Kerscher
SUMO proteases of the SENP/Ulp family are master regulators of both sumoylation and desumoylation and regulate SUMO homeostasis in eukaryotic cells. SUMO conjugates rapidly increase in response to cellular stress, including nutrient starvation, hypoxia, osmotic stress, DNA damage, heat shock, and other proteotoxic stressors. Nevertheless, little is known about the regulation and targeting of SUMO proteases during stress. To this end we have undertaken a detailed comparison of the SUMO-binding activity of the budding yeast protein Ulp1 (ScUlp1) and its ortholog in the thermotolerant yeast Kluyveromyces marxianus, KmUlp1...
2018: PloS One
https://www.readbyqxmd.com/read/29342062/potential-sex-bias-exists-in-orthopaedic-basic-science-and-translational-research
#2
Jessica Bryant, Paul Yi, Liane Miller, Kacy Peek, Daniel Lee
BACKGROUND: Potential sex bias has been shown in general surgery basic science and translational research, with unequal representation of male and female specimens. Because basic science research forms the foundation for clinical studies on which patient care is based, it is important that this research equally consider both sexes. The purpose of this study was to determine if potential sex bias exists in the basic science and translational orthopaedic literature. METHODS: A systematic review was conducted of all articles published in 2014 in The Journal of Bone & Joint Surgery, Clinical Orthopaedics and Related Research, The Bone & Joint Journal, and the Journal of Orthopaedic Research (JOR)...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341426/biomechanical-histological-and-computed-x-ray-tomographic-analyses-of-hydroxyapatite-coated-peek-implants-in-an-extended-healing-model-in-rabbit
#3
Pär Johansson, Sargon Barkarmo, Mohammed Hawthan, Niccolò Peruzzi, Per Kjellin, Ann Wennerberg
No abstract text is available yet for this article.
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29337957/moon-shot
#4
Katie Peek
No abstract text is available yet for this article.
January 16, 2018: Scientific American
https://www.readbyqxmd.com/read/29337946/misled-penguins
#5
Katie Peek
No abstract text is available yet for this article.
January 16, 2018: Scientific American
https://www.readbyqxmd.com/read/29337596/the-influence-of-graft-fixation-methods-on-revision-rates-after-primary-anterior-cruciate-ligament-reconstruction
#6
Niclas H Eysturoy, Kåre Amtoft Nissen, Torsten Nielsen, Martin Lind
BACKGROUND: The method of graft fixation in primary anterior cruciate ligament (ACL) reconstruction is important for initial stability of the graft. Poor graft fixation can result in failure of the reconstruction. The effect of ACL graft fixation principles and fixation implant combinations on the risk of revision after ACL reconstruction is not well understood. PURPOSE: The study aimed to compare the risk of revision among 4 categories of femoral fixation divided by their principle of function using a hamstring tendon (HT) graft only...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29329197/long-term-functional-outcome-of-surgical-treatment-for-thoracic-outlet-syndrome
#7
Jesse Peek, Cornelis G Vos, Çağdas Ünlü, Michiel A Schreve, Rob H W van de Mortel, Jean-Paul P M de Vries
First rib resection for thoracic outlet syndrome (TOS) is clinically successful and safe in most patients. However, long-term functional outcomes are still insufficiently known. Long-term functional outcome was assessed using a validated questionnaire. A multicenter retrospective cohort study including all patients who underwent operations for TOS from January 2005 until December 2016. Clinical records were reviewed and the long-term functional outcome was assessed by the 11-item version of the Disability of the Arm, Shoulder, and Hand (QuickDASH) questionnaire...
January 12, 2018: Diagnostics
https://www.readbyqxmd.com/read/29325889/early-cell-response-of-osteogenic-cells-on-differently-modified-implant-surfaces-sequences-of-cell-proliferation-adherence-and-differentiation
#8
Sebastian Blatt, Andreas Max Pabst, Eik Schiegnitz, Marco Hosang, Thomas Ziebart, Christian Walter, Bilal Al-Nawas, Marcus Oliver Klein
OBJECTIVES: Osseointegration of dental implants is a crucial prerequisite for long-term survival. Therefore, surface modifications are needed to interact with the extracellular environment and to trigger osteogenic cell responses such as cell proliferation, adherence, and differentiation. The purpose of this study was to investigate different surface modifications in vitro over 2 weeks. MATERIALS AND METHODS: Commercially available cells from a human osteogenic cell line (HHOB-c) were cultivated on the following surfaces: titanium with smooth surfaces (polished titanium (P), machined titanium (M), polyetheretherketone (Peek)), titanium with rough and hydrophilised surfaces (acid etched titanium (A), sandblasted acid etched titanium (SA and SA2), sandblasted acid etched hydrophilised (SAH), titanium plasma painted titanium (TPS)), titanium with calcium phosphate-containing surfaces (titanium plasma painted calcium phosphate modified titanium (TPS-CaP), sandblasted calcium phosphate modified titanium (S-CaP), sandblasted acid etched calcium phosphate modified titanium (SA-CaP)), and zirconium-oxide (yttrium amplified zirconium (Z), yttrium amplified Ca2+ delivering zirconium (Z-Ca))...
December 26, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29325887/stiffness-and-strength-of-cranioplastic-implant-systems-in-comparison-to-cranial-bone
#9
Johan Persson, Benedikt Helgason, Håkan Engqvist, Stephen J Ferguson, Cecilia Persson
PURPOSE: The aim of this study was to evaluate skull replacement options after decompressive craniectomy by systematically investigating which combination of geometrical properties and material selection would result in a mechanical response comparable in stiffness to that of native skull bone and a strength as high or higher than the same. MATERIALS AND METHODS: The study was conducted using a Finite Element Model of the top part of a human skull. Native skull bone, autografts and commercial implants made of PEEK, solid titanium, two titanium meshes and a titanium-ceramic composite were modeled under a set load to evaluate deformation and maximum stress...
December 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29322657/polyetheretherketone-overlay-prosthesis-over-high-noble-ball-attachments-to-overcome-base-metal-sensitivity-a-clinical-report
#10
Panagiotis Zoidis
A modified polyetheretherketone (PEEK) framework material in combination with heat-polymerized denture base acrylic resin was used for the fabrication of an overlay prosthesis for a patient sensitive to base metals. High noble metal was used for the fabrication of the post/coping/ball attachment assemblies to promote retention and stability. These protruding attachments into the acrylic resin could result in stress concentration; therefore, a framework is often used to strengthen the prosthesis. PEEK frameworks could be a treatment alternative to high noble or Ti frameworks since they combine good mechanical properties with biocompatibility, reduced cost, and common laboratory procedures...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29322313/implantation-of-an-empty-polyetheretherketone-cage-in-anterior-cervical-discectomy-and-fusion-a-prospective-randomised-controlled-study-with-2%C3%A2-years-follow-up
#11
Shang-Wen Feng, Ming-Chau Chang, Po-Hsin Chou, Hsi-Hsien Lin, Shih-Tien Wang, Chien-Lin Liu
PURPOSE: To compare the clinical outcomes, radiographic results and fusion rate of ACDF between empty PEEK cages and PEEK cages packed with β-tricalcium phosphate. METHODS: Forty-five patients were prospectively enrolled with cervical degenerative disc disease who requiring ACDF with a PEEK cage. 23 patients were randomised to the study group (empty cages) and 22 patients were in the control group (cages filled with β-tricalcium phosphate). Both patient groups were fixed with a cervical locking plate...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29316498/the-relation-between-having-siblings-and-children-s-cheating-and-lie-telling-behaviors
#12
Alison M O'Connor, Angela D Evans
The current study investigated how having at least one child sibling influenced children's dishonest behaviors. Furthermore, for those children with a sibling, we examined whether having a younger or older sibling and the age difference between siblings influenced deceptive acts. Children between 3 and 8 years of age (N = 130) completed the temptation resistance paradigm, where they played a guessing game and were asked not to peek at a toy in the experimenter's absence. Children's peeking behavior was used as a measure of cheating, and children's responses when asked whether they had peeked were used as measures of lie-telling...
January 6, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29313149/considerations-in-computer-aided-design-for-inlay-cranioplasty-technical-note
#13
Erik Nout, Maurice Y Mommaerts
CONTEXT: Cranioplasty is a frequently performed procedure that uses a variety of reconstruction materials and techniques. In this technical note, we present refinements of computer-aided design-computer-aided manufacturing inlay cranioplasty. OBJECTIVE, DESIGN, AND SETTING: In an attempt to decrease complications related to polyether-ether-ketone (PEEK) cranioplasty, we gradually made changes to implant design and cranioplasty techniques. These changes include under-contouring of the implant and the use of segmented plates for large defects, microplate fixation for small temporal defects, temporal shell implants to reconstruct the temporalis muscle, and perforations to facilitate the drainage of blood and cerebrospinal fluid and serve as fixation points...
January 8, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29304115/effects-of-a-self-assembling-peptide-as-a-scaffold-on-bone-formation-in-a-defect
#14
Kei Ando, Shiro Imagama, Kazuyoshi Kobayashi, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Koji Nishida, Yoshihiro Nishida, Naoki Ishiguro
Spinal fusion and bone defect after injuries, removal of bone tumors, and infections need to be repaired by implantation. In an aging society, recovery from these procedures is often difficult. In this study, we found that injection of SPG-178 leads to expression of several bone marker genes and mineralization in vitro, and revealed a significantly higher degree of newly formed bone matrix with use of SPG-178 in vivo. MC3T3-E1 cells were used to evaluate osteoblast differentiation promoted by SPG-178. To analyze gene expression, total RNA was isolated from MC3T3-E1 cells cultured for 7 and 14 days with control medium or SPG-178 medium...
2018: PloS One
https://www.readbyqxmd.com/read/29299838/optimization-of-feasibility-stage-for-hydrogen-deuterium-exchange-mass-spectrometry
#15
Yoshitomo Hamuro, Stephen J Coales
The practice of HDX-MS remains somewhat difficult, not only for newcomers but also for veterans, despite its increasing popularity. While a typical HDX-MS project starts with a feasibility stage where the experimental conditions are optimized and the peptide map is generated prior to the HDX study stage, the literature usually reports only the HDX study stage. In this protocol, we describe a few considerations for the initial feasibility stage, more specifically, how to optimize quench conditions, how to tackle the carryover issue, and how to apply the pepsin specificity rule...
January 3, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29294665/the-interaction-of-dopamine-genes-and-financial-stressors-to-predict-adulthood-intimate-partner-violence-perpetration
#16
Laura M Schwab-Reese, Edith A Parker, Corinne Peek-Asa
Three dopamine genes (DAT1, DRD2, and DRD4) have been associated with interpersonal delinquency, aggression, and violence when individuals experience adverse environmental exposures. Guided by the catalyst model of aggression, risk alleles identified in previous studies were hypothesized to be associated with intimate partner violence (IPV) perpetration in the presence of financial stressors, a possible environmental trigger. This hypothesis was tested using weighted, clustered logistic regression with data from the National Longitudinal Study of Adolescent to Adult Health...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291503/smart-release-of-doxorubicin-loaded-on-polyetheretherketone-peek-surface-with-3d-porous-structure
#17
Liping Ouyang, Zhenjie Sun, Donghui Wang, Yuqin Qiao, Hongqin Zhu, Xiaohan Ma, Xuanyong Liu
It is important to fabricate an implant possessing environment sensitive drug delivery. In this work, the construction of 3D porous structure on polyetheretherketone (PEEK) surface and pH sensitive polymer, chitosan, was introduced. The smart release of doxorubicin can be realized on the 3D porous surface of PEEK loading chitosan. We give a feasible explanation for the effect of chitosan on smart drug release according to Henderson-Hasselbalch equation. Furthermore, the intracellular drug content of the cell cultured on the samples with highest chitosan is significantly higher at pH 4...
December 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29288855/biomechanical-analysis-of-porous-additive-manufactured-cages-for-lateral-lumbar-interbody-fusion-a-finite-element-analysis
#18
Zhenjun Zhang, Hui Li, Guy R Fogel, Zhenhua Liao, Yang Li, Weiqiang Liu
BACKGROUND: A porous additive manufactured (AM) cage may provide stability similar to that of traditional solid cages, and may be beneficial to bone ingrowth. The biomechanical influence of various porous cages on stability, subsidence, stresses in cage, and facet contact force has not been fully described. The purpose of this study was to verify biomechanical effects of porous AM cages. METHODS: The surgical FE models with various cages were constructed. The partially porous titanium (PPT) cages and fully porous titanium (FPT) cages were applied...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29287950/subpectoral-biceps-tenodesis-with-peek-interference-screw-a-biomechanical-analysis-of-humeral-fracture-risk
#19
Christopher R Mellano, Rachel M Frank, Jason J Shin, Akshay Jain, William A Zuke, Randy Mascarenhas, Elizabeth Shewman, Brian J Cole, Anthony A Romeo, Nikhil N Verma, Brian Forsythe
PURPOSE: To quantify the torsional load to fracture for subpectoral biceps tenodesis with interference screw fixation. METHODS: We randomized 28 specimens from 14 matched-pair full-length humeri (mean age, 55.3 years) into 3 groups: (1) empty ream group (ERG), (2) screw-only group (SOG), and (3) screw-plus-biceps tendon group (SBG). In each group, 1 humerus of each matched pair was prepared according to group allocation and the contralateral humerus remained intact as a control...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29286967/failure-of-a-polyaryletheretherketone-cobalt-chromium-composite-femoral-stem-due-to-coating-separation-and-subsidence-a-case-report
#20
Meredith K Bartelstein, Douglas W Van Citters, Mitchell C Weiser, Calin S Moucha
CASE: A 52-year-old man who previously had undergone total hip arthroplasty with use of an Epoch (Zimmer) extensively porous-coated femoral stem presented with hip pain after a high-energy motor-vehicle accident. Radiographs demonstrated delamination at the polyaryletheretherketone-cobalt-chromium (PEEK-CoCr) core interface, which led to loosening. At revision, the implant demonstrated gross evidence of debonding at the PEEK-CoCr interface. CONCLUSION: We demonstrate clinical and tribologic evidence of a rare failure mode involving the PEEK-metal interface in a composite femoral stem, which surgeons should be aware of when evaluating patients with this type of implant...
October 2017: JBJS Case Connector
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