Sarah E Williams-Macdonald, Mairi Mitchell, David Frew, Javier Palarea-Albaladejo, David Ewing, William T Golde, David Longbottom, Alasdair J Nisbet, Morag Livingstone, Clare M Hamilton, Stephen F Fitzgerald, Søren Buus, Emil Bach, Annemieke Dinkla, Hendrik-Jan Roest, Ad P Koets, Tom N McNeilly
The bacterium Coxiella burnetii can cause the disease Q-fever in a wide range of animal hosts. Ruminants, including sheep, are thought to play a pivotal role in the transmission of C. burnetii to humans; however, the only existing livestock vaccine, namely, Coxevac® (Ceva Animal Health Ltd., Libourne, France), a killed bacterin vaccine based on phase I C. burnetii strain Nine-Mile, is only approved for use in goats and cattle. In this study, a pregnant ewe challenge model was used to determine the protective effects of Coxevac® and an experimental bacterin vaccine based on phase II C...
February 22, 2023: Vaccines