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https://www.readbyqxmd.com/read/28522991/brachyspira-hyodysenteriae-and-b-pilosicoli-proteins-recognized-by-sera-of-challenged-pigs
#1
Vanessa Casas, Arantza Rodríguez-Asiain, Roberto Pinto-Llorente, Santiago Vadillo, Montserrat Carrascal, Joaquin Abian
The spirochetes Brachyspira hyodysenteriae and B. pilosicoli are pig intestinal pathogens that are the causative agents of swine dysentery (SD) and porcine intestinal spirochaetosis (PIS), respectively. Although some inactivated bacterin and recombinant vaccines have been explored as prophylactic treatments against these species, no effective vaccine is yet available. Immunoproteomics approaches hold the potential for the identification of new, suitable candidates for subunit vaccines against SD and PIS. These strategies take into account the gene products actually expressed and present in the cells, and thus susceptible of being targets of immune recognition...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28496441/discovery-of-novel-leptospirosis-vaccine-candidates-using-reverse-and-structural-vaccinology
#2
André Alex Grassmann, Frederico Schmitt Kremer, Júlia Cougo Dos Santos, Jéssica Dias Souza, Luciano da Silva Pinto, Alan John Alexander McBride
Leptospira spp. are diderm (two membranes) bacteria that infect mammals causing leptospirosis, a public health problem with global implications. Thousands of people die every year due to leptospirosis, especially in developing countries with tropical climates. Prophylaxis is difficult due to multiple factors, including the large number of asymptomatic hosts that transmit the bacteria, poor sanitation, increasing numbers of slum dwellers, and the lack of an effective vaccine. Several leptospiral recombinant antigens were evaluated as a replacement for the inactivated (bacterin) vaccine; however, success has been limited...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28433326/status-of-the-development-of-a-vaccine-against-mycoplasma-bovis
#3
REVIEW
Jose Perez-Casal, Tracy Prysliak, Teresa Maina, Muhammad Suleman, Steve Jimbo
Mycoplasma bovis is an important pathogen of cattle and, despite numerous efforts an effective vaccine for control of the disease it causes remains elusive. Although we now know more about the biology of this pathogen, information is lacking about appropriate protective antigens, the type of immune response that confers protection and adjuvants selection. The use of conserved recombinant proteins, selected using in silico approaches, as components of a vaccine may be a better choice over bacterin-based vaccines due to the limited protection afforded by them and adverse reactions caused by them...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28391058/control-of-bovine-leptospirosis-aspects-for-consideration-in-a-tropical-environment
#4
REVIEW
G Martins, W Lilenbaum
Due to the complex and dynamic epidemiology of leptospirosis on livestock, control is still controversial and frustrating. In this context, this paper discusses the main challenges and perspectives for the control of bovine leptospirosis, particularly under tropical conditions. In order to reduce the effects of the disease in cattle, it has been proposed that the control should integrate the trinomial antibiotic therapy (mainly streptomycin); vaccination (whole-cell bacterins); and environmental management...
April 1, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28378574/efficacy-of-vaccination-and-nisin-z-treatments-to-eliminate-intramammary-staphylococcus-aureus-infection-in-lactating-cows
#5
Ran Guan, Jun-Qiang Wu, Wei Xu, Xiao-Yan Su, Song-Hua Hu
This study evaluated the effect of a Staphylococcus aureus bacterin and nisin on bovine subclinical mastitis. A total of 75 Holstein subclinically mastitic cows were randomly allocated to three groups with 25 cows per group. In group I, an intramammary infusion of nisin Z at a dose of 2.50×10(6) IU was carried out once daily for three days, and an autogenous S. aureus bacterin was inoculated into the supramammary lymph node one week before and one week after nisin treatment. In group II, nisin was administered in the same way as in group I, but no bacterin was inoculated...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28337203/a-universal-vaccine-against-leptospirosis-are-we-going-in-the-right-direction
#6
André Alex Grassmann, Jéssica Dias Souza, Alan John Alexander McBride
Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease estimated to cause severe infection in more than one million people worldwide every year that can be combated by effective immunization. However, no significant progress has been made on the leptospirosis vaccine since the advent of bacterins over 100 years. Although protective against lethal infection, particularly in animals, bacterin-induced immunity is considered short term, serovar restricted, and the vaccine can cause serious side effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28301479/ligb-subunit-vaccine-confers-sterile-immunity-against-challenge-in-the-hamster-model-of-leptospirosis
#7
Neida L Conrad, Flávia W Cruz McBride, Jéssica D Souza, Marcelle M Silveira, Samuel Félix, Karla S Mendonça, Cleiton S Santos, Daniel A Athanazio, Marco A Medeiros, Mitermayer G Reis, Odir A Dellagostin, Alan J A McBride
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laboratory diagnosis, the WHO estimates that incidence has doubled over the last 15 years to over 1 million cases that require hospitalization every year...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28284602/a-novel-chimeric-protein-composed-of-recombinant-mycoplasma-hyopneumoniae-antigens-as-a-vaccine-candidate-evaluated-in-mice
#8
Natasha Rodrigues de Oliveira, Sérgio Jorge, Charles Klazer Gomes, Caroline Rizzi, Violetta Dias Pacce, Thais Farias Collares, Leonardo Garcia Monte, Odir Antônio Dellagostin
Enzootic Pneumonia (EP) is caused by the Mycoplasma hyopneumoniae pathogenic bacteria, and it represents a significant respiratory disease that is responsible for major economic losses within the pig industry throughout the world. The bacterins that are currently commercially available have been proven to offer only partial protection against M. hyopneumoniae, and the development of more efficient vaccines is required. Several recombinant antigens have been evaluated via different immunization strategies and have been found to be highly immunogenic...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28194450/assessment-of-the-adjuvant-activity-of-mesoporous-silica-nanoparticles-in-recombinant-mycoplasma-hyopneumoniae-antigen-vaccines
#9
Veridiana Gomes Virginio, Natalia Costantin Bandeira, Fernanda Munhoz Dos Anjos Leal, Marcelo Lancellotti, Arnaldo Zaha, Henrique Bunselmeyer Ferreira
The adjuvant potential of two mesoporous silica nanoparticles (MSNs), SBa-15 and SBa-16, was assessed in combination with a recombinant HSP70 surface polypeptide domain from Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia (PEP). The recombinant antigen (HSP70212-600), previously shown as immunogenic in formulation with classic adjuvants, was used to immunize BALB/c mice in combination with SBa-15 or SBa-16 MSNs, and the effects obtained with these formulations were compared to those obtained with alum, the adjuvant traditionally used in anti-PEP bacterins...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28182704/subunit-vaccine-candidates-against-aeromonas-salmonicida-in-rainbow-trout-oncorhynchus-mykiss
#10
Moonika Haahr Marana, Louise von Gersdorff Jørgensen, Jakob Skov, Jiwan Kumar Chettri, Andreas Holm Mattsson, Inger Dalsgaard, Per Walter Kania, Kurt Buchmann
Aeromonas salmonicida subsp. salmonicida is the etiological agent of furunculosis and a major fish health problem in salmonid aquaculture worldwide. Injection vaccination with commercial mineral oil-adjuvanted bacterin vaccines has been partly successful in preventing the disease but in Danish rainbow trout (Oncorhynchus mykiss, Walbaum) aquaculture furunculosis outbreaks still occur. In this study we tested the efficacy of experimental subunit vaccines against A. salmonicida infection in rainbow trout. We utilized in silico screening of the proteome of A...
2017: PloS One
https://www.readbyqxmd.com/read/28131383/transcutaneous-immunization-of-streptococcus-suis-bacterin-using-dissolving-microneedles
#11
Kai-Jen Hsueh, Mei-Chin Chen, Li-Ting Cheng, Jai-Wei Lee, Wen-Bin Chung, Chun-Yen Chu
Vaccine delivery using microneedle (MN) patches is an easy, safe and painless alternative to traditional needle injections. In this study, we examined whether MN patches can enhance the efficacy of a Streptococcus suis serotype 2 (S. suis 2) vaccine in a mouse model. Results showed that MNs can reach 200-250μm into the skin, a depth beneficial for targeted delivery of antigens to antigen-presenting cells in the epidermis and dermis. Vaccination with prime-boost of MN induced higher levels of IgG2a antibody titer, T cell proliferation, and TH1 cytokines (IFN-γ and IL-12) as compared to intramuscular (IM) injection...
February 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28098813/reverse-vaccinology-an-approach-for-identifying-leptospiral-vaccine-candidates
#12
REVIEW
Odir A Dellagostin, André A Grassmann, Caroline Rizzi, Rodrigo A Schuch, Sérgio Jorge, Thais L Oliveira, Alan J A McBride, Daiane D Hartwig
Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by pathogenic Leptospira spp. that can infect a wide range of domestic and wild animals. Given the inability to control the cycle of transmission among animals and humans, there is an urgent demand for a new vaccine. Inactivated whole-cell vaccines (bacterins) are routinely used in livestock and domestic animals, however, protection is serovar-restricted and short-term only...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28088341/evaluation-of-an-in-house-indirect-elisa-for-detection-of-antibody-against-haemorrhagic-septicemia-in-asian-elephants
#13
Pallop Tankaew, Thawatchai Singh-La, Chatchote Titaram, Veerasak Punyapornwittaya, Preeyanat Vongchan, Takuo Sawada, Nattawooti Sthitmatee
Pasteurella multocida causes haemorrhagic septicemia in livestock and wild animals, including elephants. The disease has been reported in Asian elephants in India and Sri Lanka, but to date there have been no reported cases in Thailand. ELISA or indirect hemagglutination assays (IHA) have been demonstrated to be able to detect the antibody against the disease in cattle, but no data are available for elephants. The present study reports a novel in-house indirect ELISA for antibody detection of haemorrhagic septicemia in Asian elephants, and evaluates the sensitivity and specificity of the method using a Bayesian approach...
January 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28061775/immunization-with-streptococcus-suis-bacterin-plus-recombinant-sao-protein-in-sows-conveys-passive-immunity-to-their-piglets
#14
RANDOMIZED CONTROLLED TRIAL
Kai-Jen Hsueh, Li-Ting Cheng, Jai-Wei Lee, Yao-Chi Chung, Wen-Bin Chung, Chun-Yen Chu
BACKGROUND: Streptococcus suis (S. suis) causes arthritis, meningitis, septicemia, and sudden death in pigs and is also an zoonotic agent for humans. The present study demonstrated that immunization with recombinant Sao-L (surface antigen one-L, rSao-L) protein from a strain of S. suis serotype 2 in pigs was able to increase cross-serotype protection against S. suis serotype 1 and 2 challenge. Since weaning piglets are more susceptible to S. suis infections due to the stresses associated with weaning, prepartum immunization in sows may convey passive immunity to piglets and provide protection...
January 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/27993703/the-influence-of-concentration-of-inactivated-edwardsiella-tarda-bacterin-and-immersion-time-on-antigen-uptake-and-expression-of-immune-related-genes-in-japanese-flounder-paralichthys-olivaceus
#15
REVIEW
Yang Du, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Our previous work has demonstrated that the immune response of Japanese flounder was associated with the concentration of formalin-inactivated Edwardsiella tarda and immersion time. In order to further investigate the influence of immersion vaccine dose and bath time on the antigen uptake, formalin-killed Edwardsiella tarda bacterin was prepared and adjusted to four concentrations (10(9), 10(8), 10(7), 10(6) cfu ml(-1)) for 30, 60 and 90 min immersion in Japanese flounder model, respectively. Absolute quantitative real-time PCR was employed to examine the bacterin uptake in gill, skin, spleen and kidney at 3 and 6 h post vaccination...
February 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27939551/antimicrobial-treatment-of-clinical-mastitis-in-the-eastern-united-states-the-influence-of-dairy-farmers-mastitis-management-and-treatment-behavior-and-attitudes
#16
J Kayitsinga, R L Schewe, G A Contreras, R J Erskine
To assess both the behaviors and social variables related to antimicrobial therapy for clinical mastitis, we sent a survey to 1,700 dairy farms in Michigan, Pennsylvania, and Florida in January and February 2013. The survey included questions related to 7 major areas: sociodemographic and farm characteristics, milking proficiency, milking systems, cow environment, infected cow monitoring and treatment, farm labor, and attitudes toward mastitis and related antimicrobial use. The overall response rate was 41% (21% in Florida, 39% in Michigan, and 45% in Pennsylvania)...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27938705/antibody-profiling-of-canine-igg-responses-to-the-ospc-protein-of-the-lyme-disease-spirochetes-supports-a-multivalent-approach-in-vaccine-and-diagnostic-assay-development
#17
Lee D Oliver, Christopher G Earnhart, DeLacy Virginia-Rhodes, Michael Theisen, Richard T Marconi
OspC performs essential functions during the enzootic cycle of the Lyme disease (LD) spirochetes. In this study, the specificity of antibody (Ab) responses to OspC was profiled to define the antigenic determinants during infection and after vaccination. Several OspC variants or 'types' were screened with serum from SNAP4Dx C6 positive dogs and with serum from rabbits hyperimmunized with OspC proteins. The OspC type-specific nature of the Ab response revealed that variable domains of OspC are immunodominant during infection and upon vaccination...
December 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27902896/the-efficacy-of-chitosan-adjuvanted-mycoplasma-gallisepticum-bacterin-in-chickens
#18
Arithat Limsatanun, Jiroj Sasipreeyajan, Somsak Pakpinyo
Mycoplasma gallisepticum (MG) is one of the major pathogens that cause respiratory signs in the poultry industry. To control MG infection, vaccination is the useful procedure. In this study, MG vaccine was developed by using the local Thai MG isolate (AHRL 20/52). Chitosan, a polysaccharide adjuvant derived from crustaceans, has been successfully used in various vaccines. The objectives of this study were to prepare MG bacterins by using chitosan, serving as an adjuvant, to determine protection against the field Thai MG isolate and to evaluate tissue reaction at the injection site...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27864157/the-effect-of-feed-based-vaccination-on-tilapia-farm-endemic-for-streptococcosis
#19
M S Ismail, M R Syafiq, A Siti-Zahrah, S Fahmi, H Shahidan, Y Hanan, M N A Amal, M Zamri Saad
A tilapia farm experiencing endemic streptococcosis was selected to study the effect of vaccination with a feed-based vaccine on naturally ocurring streptococcosis. A total of 9000 red tilapia, Oreochromis niloticus × Oreochromis mossambicus of 100 ± 20 g were divided into 9 cages. Fish of Group 1 in cages 1, 2 and 3 were not vaccinated. Group 2 in cages 4, 5 and 6 were vaccinated on days 0 and 14 (single booster) while Group 3 in cages 7, 8 and 9 were vaccinated on days 0, 14 and 42 (double booster)...
January 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27786163/evaluation-of-anti-erysipelothrix-rhusiopathiae-igg-response-in-bottlenose-dolphins-tursiops-truncatus-to-a-commercial-pig-vaccine
#20
Hendrik H Nollens, Luis G Giménez-Lirola, Todd R Robeck, Todd L Schmitt, Stacy DiRocco, Tanja Opriessnig
Erysipelothrix rhusiopathiae is the causative agent of erysipeloid in humans and of erysipelas in various animals, including bottlenose dolphins Tursiops truncatus, in which an infection has the potential to cause peracute septicemia and death. The purpose of this study was to evaluate the efficacy of using an off-label porcine (ER BAC PLUS®, Zoetis) E. rhusiopathiae bactrin in a bottlenose dolphin vaccination program by determining the anti-E. rhusiopathiae antibody levels in vaccinated dolphins over a 10 yr period...
October 27, 2016: Diseases of Aquatic Organisms
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