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Lifenet, allograft

Adam Landsman, Eran Rosines, Amanda Houck, Angela Murchison, Alyce Jones, Xiaofei Qin, Silvia Chen, Arnold R Landsman
OBJECTIVE: The purpose of this study was to examine the characteristics of a cryopreserved split-thickness skin allograft produced from donated human skin and compare it with fresh, unprocessed human split-thickness skin. BACKGROUND: Cutaneous wound healing is a complex and organized process, where the body re-establishes the integrity of the injured tissue. However, chronic wounds, such as diabetic or venous stasis ulcers, are difficult to manage and often require advanced biologics to facilitate healing...
September 2016: Advances in Skin & Wound Care
Richard J Miron, Qiao Zhang, Anton Sculean, Daniel Buser, Benjamin E Pippenger, Michel Dard, Yoshinori Shirakata, Fatiha Chandad, Yufeng Zhang
OBJECTIVES: Guided bone regeneration (GBR) aims to predictably restore missing bone that has been lost due to trauma, periodontal disease or a variety of systemic conditions. Critical to this procedure is the ability of a bone grafting material to predictably serve as a 3-dimensional scaffold capable of inducing cell and bone tissue in-growth at the material surface. Although all bone grafts are osteoconductive to bone-forming osteoblasts, only a small number of commercially available bone grafts with FDA approval are osteoinductive including demineralized freeze-dried bone allographs (DFDBA) and scaffolds containing bone morphogenetic proteins (BMPs)...
January 27, 2016: Clinical Oral Investigations
Francesco Cairo, Umberto Pagliaro
No abstract text is available yet for this article.
September 2015: Journal of Evidence-based Dental Practice
Knut Beitzel, Mary Beth McCarthy, Mark P Cote, Ryan P Russell, John Apostolakos, Daisy M Ramos, Sangamesh G Kumbar, Andreas B Imhoff, Robert A Arciero, Augustus D Mazzocca
PURPOSE: The purpose of this study was to examine, in vitro, the cellular response of human mesenchymal stem cells (MSCs) to sample types of commercially available scaffolds in comparison with control, native tendon tissue (fresh-frozen rotator cuff tendon allograft). METHODS: MSCs were defined by (1) colony-forming potential; (2) ability to differentiate into tendon, cartilage, bone, and fat tissue; and (3) fluorescence-activated cell sorting analysis (CD73, CD90, CD45)...
March 2014: Arthroscopy: the Journal of Arthroscopic & related Surgery
Richard A Hopkins, Gary K Lofland, Jennifer Marshall, Diana Connelly, Gayathri Acharya, Pamela Dennis, Richard Stroup, Chris McFall, James E O'Brien
BACKGROUND: Decellularized allogeneic nonvalved pulmonary artery patches for arterioplasty are a relatively new option compared with cryopreserved allogeneic, crosslinked xenogeneic bioprosthetic or synthetic materials. This study examines the midterm experience with a new decellularized allogeneic patch for congenital cardiac reconstructions. METHODS: For this prospective postmarket approval, nonrandomized, inclusive observational study, we collected data on a consecutive cohort of 108 patients with cardiovascular reconstructions using 120 decellularized allogeneic pulmonary artery patches (MatrACELL; LifeNet Health, Inc, Virginia Beach, VA) between September 2009 and December 2012...
April 2014: Annals of Thoracic Surgery
Shuang Yang, Liao Lan, Richard J Miron, Lingfei Wei, Meng Zhang, Yufeng Zhang
BACKGROUND: Replacement bone grafting materials are used clinically for a variety of clinical procedures to augment and replace lost or missing bone. Little information is available regarding their degradation properties. PURPOSE: The aim of the present study was to investigate the degradation rate and modes of degradation of four commonly used bone grafting materials. MATERIALS AND METHODS: A natural bone mineral (NBM) of bovine origin, NBM in combination with enamel matrix derivative (EMD), LifeNet demineralized freeze-dried bone allograft (DFDBA), and Osteotech DFDBA were analyzed for particle degradation over time in 3 mm femur defects created in female Wistar rats...
October 2015: Clinical Implant Dentistry and related Research
Lingfei Wei, Richard J Miron, Bin Shi, Yufeng Zhang
OBJECTIVE: The purpose of this investigation was to compare the osteoinductive and osteopromotive potential of two widely used demineralized freeze-dried bone allografts (DFDBA) (Osteotech® DFDBA and LifeNet® DFDBA). MATERIAL AND METHODS: Twenty-seven male Wistar rats (mean body weight 200 g) were treated with either DFDBA from Osteotech and LifeNet or control for femoral and intramuscular defects and assigned to histological analysis at 2, 4, and 8 weeks postimplantation...
June 2015: Clinical Implant Dentistry and related Research
Adam M Shiroff, Stephen C Gale, Mark A Merlin, Jessica S Crystal, Matt Linger, Anar D Shah, Erin Beaumont, Elie Lustiger, Erica Tabakin, Vicente H Gracias
INTRODUCTION: Tissue transplantation is an important adjunct to modern medical care and is used daily to save or improve patient lives. Tissue allografts include bone, tendon, corneas, heart valves and others. Increasing utilization may lead to tissue shortages, and tissue procurement organizations continue to explore ways to expand the cadaveric donor pool. Currently more than half of all deaths occur outside the acute care setting. HYPOTHESIS: Many who suffer prehospital deaths might be eligible for non-organ tissue donation...
April 2013: Prehospital and Disaster Medicine
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