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JOURNAL ARTICLE
Ivan Talucci, Friederike A Arlt, Kai O Kreissner, Mahoor Nasouti, Anna-Lena Wiessler, Ramona Miske, Swantje Mindorf, Inga Dettmann, Mehrnaz Moniri, Markus Bayer, Peter Broegger Christensen, Ilya Ayzenberg, Andrea Kraft, Matthias Endres, Lars Komorowski, Carmen Villmann, Kathrin Doppler, Harald Prüss, Hans M Maric
INTRODUCTION: Subgroups of autoantibodies directed against voltage-gated potassium channel (Kv ) complex components have been associated with immunotherapy-responsive clinical syndromes. The high prevalence and the role of autoantibodies directly binding Kv remain, however, controversial. Our objective was to determine Kv autoantibody binding requirements and to clarify their contribution to the observed immune response. METHODS: Binding epitopes were studied in sera (n = 36) and cerebrospinal fluid (CSF) (n = 12) from a patient cohort positive for Kv 1...
2024: Frontiers in Immunology
#2
JOURNAL ARTICLE
Xuewen Zhou, Gangwen Guo, Shanzi Yu, Rong Hu
OBJECTIVES: Trigeminal neuralgia (TN) is a common neuropathic pain. Voltage-gated potassium channel (Kv) has been confirmed to be involved in the occurrence and development of TN, but the specific mechanism is still unclear. MicroRNA may be involved in neuropathic pain by regulating the expression of Kv channels and neuronal excitability in trigeminal ganglion (TG). This study aims to explore the relationship between Kv1.1 and miR-21-5p in TG with a TN model, evaluate whether miR-21-5p has a regulatory effect on Kv1...
January 28, 2024: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#3
JOURNAL ARTICLE
Vivien Jusztus, Ghofrane Medyouni, Adrienn Bagosi, Rudolf Lampé, György Panyi, Orsolya Matolay, Eszter Maka, Zoárd Tibor Krasznai, Orsolya Vörös, Péter Hajdu
CD8+ T cells play a role in the suppression of tumor growth and immunotherapy. Ion channels control the Ca2+ -dependent function of CD8+ lymphocytes such as cytokine/granzyme production and tumor killing. Kv1.3 and KCa3.1 K+ channels stabilize the negative membrane potential of T cells to maintain Ca2+ influx through CRAC channels. We assessed the expression of Kv1.3, KCa3.1 and CRAC in CD8+ cells from ovarian cancer (OC) patients ( n = 7). We found that the expression level of Kv1.3 was higher in patients with malignant tumors than in control or benign tumor groups while the KCa3...
February 6, 2024: International Journal of Molecular Sciences
#4
JOURNAL ARTICLE
Anatoli Y Kabakov, Karim Roder, Peter Bronk, Nilüfer N Turan, Saroj Dhakal, Mingwang Zhong, Yichun Lu, Yonatan B Najman-Licht, Alain Karma, Gideon Koren
Genome-wide association studies (GWAS) have reported a correlation between a single nucleotide polymorphism of the RING finger E3 ubiquitin protein ligase rififylin (RFFL) and QT interval variability in humans (Newton-Cheh et al., 2009). Previously, we have shown that RFFL down-regulates expression and function of the human-like ether-a-go-go-related gene (hERG) potassium channel and corresponding rapidly activating delayed rectifier potassium current (IKr ) in adult rabbit ventricular cardiomyocytes (ARbCMs)...
February 15, 2024: Journal of Biological Chemistry
#5
JOURNAL ARTICLE
Friederike A Arlt, Ramona Miske, Marie-Luise Machule, Peter Broegger Christensen, Swantje Mindorf, Bianca Teegen, Kathrin Borowski, Maria Buthut, Rosa Rößling, Elisa Sanchez-Sendin, Scott van Hoof, César Cordero-Gómez, Isabel Bünger, Helena Radbruch, Andrea Kraft, Ilya Ayzenberg, Jaqueline Klausewitz, Niels Hansen, Charles Timäus, Peter Körtvelyessy, Thomas Postert, Kirsten Baur-Seack, Constanze Rost, Robert Brunkhorst, Kathrin Doppler, Niklas Haigis, Gerhard Hamann, Albrecht Kunze, Alexandra Stützer, Matthias Maschke, Nico Melzer, Felix Rosenow, Kai Siebenbrodt, Christian Stenør, Martin Dichgans, Marios K Georgakis, Rong Fang, Gabor C Petzold, Michael Görtler, Inga Zerr, Silke Wunderlich, Ivan Mihaljevic, Paul Turko, Marianne Schmidt Ettrup, Emilie Buchholz, Helle Foverskov Rasmussen, Mahoor Nasouti, Ivan Talucci, Hans M Maric, Stefan H Heinemann, Matthias Endres, Lars Komorowski, Harald Prüss
BACKGROUND: Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice. DESIGN / METHODS: We retrospectively collected comprehensive clinical and paraclinical data of 35 patients with KCNA2 IgG autoantibodies detected in cell-based and tissue-based assays. Patients' sera and cerebrospinal fluid (CSF) were used for characterization of the antigen, clinical-serological correlations, and determination of IgG subclasses...
February 1, 2024: Brain, Behavior, and Immunity
#6
JOURNAL ARTICLE
Shigeaki Suzuki
Neurological and muscular immune-related adverse events (irAEs) associated with cancer treatment using immune checkpoint inhibitors (ICIs) may show a diverse clinical presentation. Myasthenia gravis (MG) represents a serious irAE associated with the aforementioned therapy. Recent studies have discussed the clinical features of MG that occurs as an irAE (irAE-MG). The incidence of irAE-MG is estimated to be 1%. This complication occurs during the early phase of ICI treatment and rapidly worsens, resulting in severe bulbar muscle involvement and myasthenic crisis and significantly elevated serum creatine kinase levels...
January 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
#7
JOURNAL ARTICLE
Ramisha A Rahman, Bushra Zaman, Mohammad Radid Khan, Md Shariful Islam, Md Harunur Rashid
The KCNA5 gene provides the code for the α-subunit of the potassium channel Kv1.5. The genetic variant H463R in the Kv1.5 channel has been reported to cause a functional loss in atrial fibrillation (AF) patients. Understanding the mutations at a molecular level is key to developing improved therapeutics concerning cardiac hKv1.5 and hKv1.4 channels. Molecular dynamics and umbrella sampling free energy simulations are an effective tool to understand the mutation's effect on ion conduction, which we have employed and found that the hKv1...
January 5, 2024: Journal of Physical Chemistry. B
#8
JOURNAL ARTICLE
Bo Wang, Jie Chen, Shuhong Wang, Lin Chen, Xuyang Zhang, Tengyuan Zhou, Jun Zhong, Chao Zhang, Yijia He, Yonglin Zuo, Hua Feng, Yi Yin, Hongfei Ge
BACKGROUND: White matter injury (WMI) in basal ganglia usually induces long-term disability post intracerebral hemorrhage (ICH). Kv1.3 is an ion channel expressed in microglia and induces neuroinflammation after ICH. Here, we investigated the functions and roles of Kv1.3 activation-induced inflammatory response in WMI and the Kv1.3 blockade effect on microglia polarization after ICH. METHODS: Mice ICH model was constructed by autologous blood injection. The expression of Kv1...
December 5, 2023: Journal of Integrative Neuroscience
#9
JOURNAL ARTICLE
Tianxin Ye, Zhuonan Song, Yunping Zhou, Zhangchi Liu, Yi Yu, Fangcong Yu, Yanan Chu, Jiaran Shi, Longbo Wang, Cui Zhang, Xin Liu, Bo Yang, Jinxiu Yang, Xingxiang Wang
Atrial fibrillation (AF) is common in pulmonary hypertension (PH), whereas the mechanisms and treatments remain to be explored. TRPV2 regulates the structure and function of the cardiovascular system; however, little attention has been given to its role in AF. This study was to determine whether TRPV2 was involved in PH-induced AF and the effects of TRPV2 inhibitor tranilast on AF in rat models of PH. Monocrotaline (MCT) and SU5416/hypoxia (SuHx)-induced PH models were performed to detect atrial electrophysiological parameters...
December 21, 2023: Cell Calcium
#10
JOURNAL ARTICLE
Ruiming Zhao, Arwa Qasim, Punyanuch Sophanpanichkul, Hui Dai, Maha Nayak, Inbal Sher, Jordan Chill, Steve A N Goldstein
Dysfunction of the human voltage-gated K+ channel Kv1.1 has been associated with epilepsy, multiple sclerosis, episodic ataxia, myokymia, and cardiorespiratory dysregulation. We report here that AETX-K, a sea anemone type I (SAK1) peptide toxin we isolated from a phage display library, blocks Kv1.1 with high affinity (Ki ~ 1.6 pM) and notable specificity, inhibiting other Kv channels we tested a million-fold less well. Nuclear magnetic resonance (NMR) was employed both to determine the three-dimensional structure of AETX-K, showing it to employ a classic SAK1 scaffold while exhibiting a unique electrostatic potential surface, and to visualize AETX-K bound to the Kv1...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#11
JOURNAL ARTICLE
Kenshiro Fuse, Amane Araki, Saori Morozumi, Keizo Yasui, Tomoyuki Kazuta, Seiya Noda, Masahisa Katsuno
An 84-year-old man was diagnosed with anti-acetylcholine receptor (AChR) antibody-positive ocular myasthenia gravis (OMG) at the age of 77 and received treatment. The patient was referred to our department with swelling and pain in his right upper arm, which had spread to other limbs. His serum anti-AChR antibody and creatine kinase levels were elevated, and MRI of the limbs displayed signal changes suggesting inflammation in the several muscles. Despite showing no sign of thymoma, he was positive for serum anti-titin and anti-Kv1...
November 22, 2023: Rinshō Shinkeigaku, Clinical Neurology
#12
REVIEW
Sodikdjon A Kodirov
Voltage-dependent K+ (Kv) channels are diverse, comprising the classical Shab - Kv2, Shaker - Kv1, Shal - Kv4, and Shaw - Kv3 families. The Shaker family alone consists of Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, and Kv1.7. Moreover, the Shab family comprises two functional (Kv2.1 and Kv2.2) and several "silent" alpha subunits (Kv2.3, Kv5, Kv6, Kv8, and Kv9), which do not generate K current. However, e.g., Kv8.1, via heteromerization, inhibits outward currents of the same family or even that of Shaw ...
October 2023: Biophysical Reviews
#13
JOURNAL ARTICLE
Yuki Kitazaki, Osamu Yamamura, Kojiro Usui, Asako Ueno, Sayaka Sanada, Hirohito Sasaki, Yoshinori Endo, Soichi Enomoto, Masamichi Ikawa, Yasunari Nakamoto, Tadanori Hamano
Nivolumab blocks inhibitors of T-cell activation and restores antitumor immunity but promotes T-cell activity in host tissues by blocking inhibition of the T-cell function, resulting in immune-related adverse effects. We herein report an 80-year-old man presenting with nivolumab-related myasthenia gravis with anti-muscular voltage-gated potassium channel-complex (Kv1.4) antibodies. On day 29 after nivolumab administration, he simultaneously developed rapidly progressing right ptosis and left facial paralysis...
2023: Internal Medicine
#14
JOURNAL ARTICLE
Giulia Schilardi, Jakub Kralik, Sonja Kleinlogel
Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina: bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar cells (OBCs) represent an attractive target for optogenetic vision restoration. However, the above-described maladaptations may negatively impact the quality of restored vision. To investigate this question, we employed human post-mortem retinas and transgenic rd1_Opto-mGluR6 mice expressing the optogenetic construct Opto-mGluR6 in OBCs and carrying the retinal degeneration rd1 mutation...
September 18, 2023: International Journal of Molecular Sciences
#15
JOURNAL ARTICLE
Cesare Sala, Martina Staderini, Tiziano Lottini, Claudia Duranti, Gabriele Angelini, Gabriela Constantin, Annarosa Arcangeli
The functional relevance of K+ and Ca2+ ion channels in the "Store Operated Calcium Entry" (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined. In this scenario, our aim was to characterize the expression of the ether à-go-go-related gene 1 (ERG1) and KV 1.3 K+ channels during the early stages of mouse lymphopoiesis and analyze how they affect Ca2+ signaling, or other signaling pathways, known to mediate selection and differentiation processes of lymphoid clones...
2023: Frontiers in Immunology
#16
JOURNAL ARTICLE
Kimberly Rockley, Ruth Roberts, Hannah Jennings, Karen Jones, Myrtle Davis, Paul Levesque, Michael Morton
Seizure liability remains a significant cause of attrition throughout drug development. Advances in stem cell biology coupled with an increased understanding of the role of ion channels in seizure offer an opportunity for a new paradigm in screening. We assessed the activity of 15 pro-seizurogenic compounds (7 CNS active therapies, 4 GABA receptor antagonists and 4 other reported seizurogenic compounds) using automated electrophysiology against a panel of 14 ion channels (Nav1.1, Nav1.2, Nav1.6, Kv7.2/7.3, Kv7...
August 26, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
#17
JOURNAL ARTICLE
Kashmala Shakeel, Timoteo Olamendi-Portugal, Muhammad Umair Naseem, Baltazar Becerril, Fernando Z Zamudio, Gustavo Delgado-Prudencio, Lourival Domingos Possani, Gyorgy Panyi
Seven new peptides denominated CboK1 to CboK7 were isolated from the venom of the Mexican scorpion Centruroides bonito and their primary structures were determined. The molecular weights ranged between 3760.4 Da and 4357.9 Da, containing 32 to 39 amino acid residues with three putative disulfide bridges. The comparison of amino acid sequences with known potassium scorpion toxins (KTx) and phylogenetic analysis revealed that CboK1 (α-KTx 10.5) and CboK2 (α-KTx 10.6) belong to the α-KTx 10.x subfamily, whereas CboK3 (α-KTx 2...
August 15, 2023: Toxins
#18
JOURNAL ARTICLE
Yingping Liang, Dilip Sharma, Bing Wang, Huixing Wang, Xiaozhou Feng, Ruining Ma, Tolga Berkman, Steven Char, Alex Bekker, Yuan-Xiang Tao
Nerve injury-induced alternations of gene expression in primary sensory neurons of dorsal root ganglion (DRG) are molecular basis of neuropathic pain genesis. Transcription factors regulate gene expression. In this study, we examined whether early B cell factor 1 (EBF1), a transcription factor, in the DRG participated in neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. EBF1 was distributed exclusively in neuronal nucleus and co-expressed with cytoplasmic/membrane Kv1.2 in individual DRG neurons...
August 20, 2023: Translational Research: the Journal of Laboratory and Clinical Medicine
#19
JOURNAL ARTICLE
Xiaofei Zhao, Wen Ding, Hongguang Wang, Yize Wang, Yanjiang Liu, Yongdong Li, Chunliang Liu
As biomolecules vibrate and rotate in the terahertz band, the biological effects of terahertz electromagnetic fields have drawn considerable attention from the physiological and medical communities. Ion channels are the basis of biological electrical signals, so studying the effect of terahertz electromagnetic fields on ion channels is significant. In this paper, the effect of a terahertz electromagnetic field with three different frequencies, 6, 15, and 25 THz, on the Kv1.2 potassium ion channel was investigated by molecular dynamics simulations...
July 28, 2023: Journal of Chemical Physics
#20
JOURNAL ARTICLE
Chi Che, Xiao-Lin Wang, Zhi-Yong Chen, Mei-Qun Zheng, Wei Tang, Zong-Qiong Lu, Jia-Shuai Guo, Wan-Qing Huang, Xin Tian, Lin Li
This study aimed to investigate the underlying mechanism of Zhenwu Decoction in the treatment of heart failure by regulating electrical remodeling through the transient outward potassium current(I_(to))/voltage-gated potassium(Kv) channels. Five normal SD rats were intragastrically administered with Zhenwu Decoction granules to prepare drug-containing serum, and another seven normal SD rats received an equal amount of distilled water to prepare blank serum. H9c2 cardiomyocytes underwent conventional passage and were treated with angiotensin Ⅱ(AngⅡ) for 24 h...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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