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https://www.readbyqxmd.com/read/29343583/structural-study-of-the-c-terminal-domain-of-non-structural-protein-1-from-japanese-encephalitis-virus
#1
Thanalai Poonsiri, Gareth S A Wright, Michael S Diamond, Lance Turtle, Tom Solomon, Svetlana V Antonyuk
Japanese encephalitis virus (JEV) is a mosquito-transmitted Flavivirus that is closely related to other emerging viral pathogens including dengue, West Nile (WNV) and Zika viruses. JEV infection can result in meningitis and encephalitis, which in severe cases cause permanent brain damage and death. JEV occurs predominantly in rural areas throughout Southeast Asia, the Pacific islands and the Far East, causing around 68,000 cases worldwide each year. In this study, we present a 2.1 Å resolution crystal structure of the C-terminal β-ladder domain of JEV non-structural protein 1 (NS1-C)...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29325161/five-year-antibody-persistence-following-a-japanese-encephalitis-chimeric-virus-vaccine-je-cv-booster-in-je-cv-primed-children-in-the-philippines
#2
Maria Rosario Capeding, Edison R Alberto, Alain Bouckenooghe, Thelma M Laot, Danaya Chansinghakul, Céline Monfredo, Tifany Machabert, Emmanuel Feroldi
NCT01190228.
January 9, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29323278/structural-biology-of-zika-virus-and-other-flaviviruses
#3
REVIEW
S Saif Hasan, Madhumati Sevvana, Richard J Kuhn, Michael G Rossmann
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29321318/viperin-restricts-zika-virus-and-tick-borne-encephalitis-virus-replication-by-targeting-ns3-for-proteasomal-degradation
#4
Christakis Panayiotou, Richard Lindqvist, Chaitanya Kurhade, Kirstin Vonderstein, Jenny Pasto, Karin Edlund, Arunkumar S Upadhyay, Anna K Överby
Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with millions of human infections annually. Their pathogenesis ranges from mild illness to severe manifestations such as hemorrhagic fever and fatal encephalitis. Type I interferons (IFNs) are induced in response to viral infection, and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum-associated, IFN-inducible), which shows antiviral activity against a broad spectrum of viruses including several flaviviruses...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29288628/mating-behavior-of-the-west-nile-virus-vector-culex-pipiens-role-of-behavioral-asymmetries
#5
Giovanni Benelli
Culex pipiens is a vector of West Nile, Rift Valley fever, Japanese encephalitis virus and Usutu viruses. In agreement with the criteria of Integrated Vector Management, several research efforts have been devoted to develop behavior-based control tools to fight mosquito vectors. However, our knowledge of mosquito mating biology and sexual communication is still patchy. Despite the high relevance of C. pipiens as a vector of medical and veterinary importance, no studies on its mating behavior and the factors routing mating success have been conducted...
December 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29284418/the-aetiologies-of-central-nervous-system-infections-in-hospitalised-cambodian-children
#6
Paul Turner, Kuong Suy, Le Van Tan, Pora Sar, Thyl Miliya, Nguyen Thi Thu Hong, Vu Thi Ty Hang, Nguyen Thi Han Ny, Sona Soeng, Nicholas P J Day, H Rogier van Doorn, Claudia Turner
BACKGROUND: Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia. METHODS: We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens...
December 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29279446/susceptibility-status-of-japanese-encephalitis-vectors-to-insecticides-in-endemic-areas-of-northern-districts-of-west-bengal-india
#7
Pabitra Saha, Sudeep Ballav, Moytrey Chatterjee, Swagata Ganguly, Mayukh Sarker, Asit Kumar Biswas, Tulsi Pramanik, Nandita Basu, Ardhendu Kumar Maji
Emergence and spread of resistance among vectors against different insecticides is a serious problem for Japanese encephalitis (JE) control programme. Regular monitoring of susceptibility status of vector species to insecticides is important for formulating proper vector control measures. We have studied the susceptibility status of major JE vectors from northern West Bengal, against 4% DDT, 0.05% deltamethrin and 5% malathion. Two to three days old unfed female mosquitoes were subjected to susceptibility bioassay using WHO kit...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29244615/risk-assessment-for-japanese-encephalitis-vaccination
#8
Lance Turtle, Carolyn Driver
Japanese encephalitis (JE) is the most commonly diagnosed viral encephalitis in Asia. JE is caused by a virus called JE virus (JEV), a member of the genus Flavivirus, family Flaviviridae, and is transmitted by Culex mosquitoes. Neutralising antibody to JEV protects against JE, and can be induced by vaccination. JE is a potential threat to travellers to endemic areas, which are most of South and Southeast Asia and some Pacific Islands. The risk of JE can be expected to increase with increasing mosquito exposure and time spent in regions and seasons of active transmission...
December 15, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29244182/poor-performance-of-two-rapid-immunochromatographic-assays-for-anti-japanese-encephalitis-virus-immunoglobulin-m-detection-in-cerebrospinal-fluid-and-serum-from-patients-with-suspected-japanese-encephalitis-virus-infection-in-laos
#9
Onanong Sengvilaipaseuth, Josée Castonguay-Vanier, Anisone Chanthongthip, Ooyanong Phonemixay, Soulignasack Thongpaseuth, Manivanh Vongsouvath, Paul N Newton, Tehmina Bharucha, Audrey Dubot-Pérès
Background: Japanese encephalitis virus (JEV) is a leading identified cause of encephalitis in Asia, often occurring in rural areas with poor access to laboratory diagnostics. We evaluated two rapid diagnostic tests (RDTs) for anti-JEV immunoglobulin M (IgM) detection. Methods: Consecutive cerebrospinal fluid and serum from 388 patients (704 samples) with suspected JEV infections admitted to six hospitals in Laos were tested with one of two SD-Bioline anti-JEV IgM RDTs and the World Health Organization standard anti-JEV IgM enzyme-linked immunosorbent assay (ELISA; Panbio Japanese Encephalitis-Dengue IgM Combo ELISA...
December 13, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29243139/prevalence-and-risk-factors-of-japanese-encephalitis-virus-jev-in-livestock-and-companion-animal-in-high-risk-areas-in-malaysia
#10
Kiven Kumar, Siti Suri Arshad, Gayathri Thevi Selvarajah, Jalila Abu, Ooi Peck Toung, Yusuf Abba, Faruku Bande, A R Yasmin, Reuben Sharma, Bee Lee Ong, Anisah Abdul Rasid, Norsuzana Hashim, Amira Peli, E P Heshini, Ahmad Khusaini Mohd Kharip Shah
Japanese encephalitis (JE) is vector-borne zoonotic disease which causes encephalitis in humans and horses. Clinical signs for Japanese encephalitis virus (JEV) infection are not clearly evident in the majority of affected animals. In Malaysia, information on the prevalence of JEV infection has not been established. Thus, a cross-sectional study was conducted during two periods, December 2015 to January 2016 and March to August in 2016, to determine the prevalence and risk factors in JEV infections among animals and birds in Peninsular Malaysia...
December 14, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29229654/protocol-for-developing-a-database-of-zoonotic-disease-research-in-india-dozoori
#11
Pranab Chatterjee, Soumyadeep Bhaumik, Abhimanyu Singh Chauhan, Manish Kakkar
INTRODUCTION: Zoonotic and emerging infectious diseases (EIDs) represent a public health threat that has been acknowledged only recently although they have been on the rise for the past several decades. On an average, every year since the Second World War, one pathogen has emerged or re-emerged on a global scale. Low/middle-income countries such as India bear a significant burden of zoonotic and EIDs. We propose that the creation of a database of published, peer-reviewed research will open up avenues for evidence-based policymaking for targeted prevention and control of zoonoses...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29227202/challenges-of-vaccine-development-for-zika-virus
#12
Marcia A Blackman, In-Jeong Kim, Jr-Shiuan Lin, Stephen J Thomas
The emergence of outbreaks of Zika virus (ZIKV) in Brazil in 2015 was associated with devastating effects on fetal development and prompted a world health emergency and multiple efforts to generate an effective vaccine against infection. There are now more than 40 vaccine candidates in preclinical development and six in clinical trials. Despite similarities with other flaviviruses to which successful vaccines have been developed, such as yellow fever virus and Japanese Encephalitis virus, there are unique challenges to the development and clinical trials of a vaccine for ZIKV...
December 11, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29227177/immunogenicity-and-safety-of-inactivated-chromatographically-purified-vero-cell-derived-japanese-encephalitis-vaccine-in-thai-children
#13
Pornthep Chanthavanich, Kriengsak Limkittikul, Chukiat Sirivichayakul, Watcharee Chokejindachai, Weerawan Hattasingh, Krisana Pengsaa, Surachai Surangsrirat, Termsang Srisuwannaporn, Benjawan Kaewma, Sutee Yoksan, Gao Jun, Bai Zhumu
Inactivated mouse-brain-derived Japanese encephalitis vaccine has a worrisome safety profile and the live attenuated vaccine is unsuitable in immunodeficiency. This study aimed to evaluate the immunogenicity and safety of an inactivated chromatographically purified Vero-cell-derived JE vaccine (CVI-JE, Beijing P-3 strain) in children. 152 healthy Thai children, with an average (SD) age of 14.4 (3.8) months, received 3 doses of CVI-JE on days 0, 7-28, and one year. Homologous JE neutralizing antibody titers (NT) were measured...
December 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29226169/prolonged-detection-of-japanese-encephalitis-virus-in-urine-and-whole-blood-in-a-returned-short-term-traveler
#14
G Khai Lin Huang, Shio Yen Tio, Leon Caly, Suellen Nicholson, Irani Thevarajan, Georgina Papadakis, Mike Catton, Steven Y C Tong, Julian Druce
We describe a fatal case of Japanese encephalitis virus infection following short-term travel to Thailand. Viral RNA was detected in urine and whole blood out to 26 and 28 days, respectively, after the onset of symptoms. Live virus was isolated from a urine specimen from day 14.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29217376/safety-tolerability-and-immunogenicity-of-two-zika-virus-dna-vaccine-candidates-in-healthy-adults-randomised-open-label-phase-1-clinical-trials
#15
Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen
BACKGROUND: The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. METHODS: We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29210509/arboviruses-and-their-related-infections-in-china-a-comprehensive-field-and-laboratory-investigation-over-the-last-3-decades
#16
REVIEW
Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to the family Reoviridae...
December 6, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29207707/diagnostic-approach-to-viral-acute-encephalitis-syndrome-aes-in-paediatric-age-group-a-study-from-new-delhi
#17
Shipra Goel, Anita Chakravarti, Mukta Mantan, Surinder Kumar, Md Anzar Ashraf
Introduction: Acute Encephalitis Syndrome has heralded the emergence of multiple virulent pathogens, which may result in severe morbidity and mortality. In India, encephalitis is not notified and there has been a dearth of analysis for trends in encephalitis death rates and causation. A downward trend has been observed in encephalitis deaths, due to 'known' causes, which can be largely explained by improvement in diagnostic, treatment, and prevention methods. There is still a very high proportion of encephalitis deaths in developing countries, where the aetiological diagnosis of the pathogen is not established and thus, lies the importance of monitoring encephalitis morbidity and mortality with a view to improve pathogen diagnosis and identify emerging infectious diseases...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207584/mir-301a-mediated-immune-evasion-by-japanese-encephalitis-virus
#18
EDITORIAL
Bibhabasu Hazra, Surajit Chakraborty, Anirban Basu
No abstract text is available yet for this article.
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205199/seroprevalence-of-japanese-encephalitis-virus-west-nile-virus-in-alappuzha-district-kerala
#19
Anukumar Balakrishnan, Romy Jose Thekkekare, Gajanan Sapkal, Babasaheb V Tandale
BACKGROUND & OBJECTIVES: Several outbreaks of acute encephalitis syndrome (AES) have been reported in Alappuzha district, Kerala State, India, in the past. The aetiology of these outbreaks was either inconclusive or concluded as probable Japanese encephalitis virus (JEV) infection based on clinical presentation. The role of West Nile virus (WNV) in AES outbreaks was also determined. However, the extent of WNV infection has not been studied in this region previously. A population-based cross-sectional serosurvey study was undertaken to determine the seroprevalence of JEV and WNV in Alappuzha district...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29197806/immunofluorescence-based-biosensor-for-the-determination-of-dengue-virus-ns1-in-clinical-samples
#20
Nadiya T Darwish, Shamala D Sekaran, Yatimah Alias, Sook Mei Khor
The sharp increase in incidence of dengue infection has necessitated the development of methods for the rapid diagnosis of this deadly disease. Here we report the design and development of a reliable, sensitive, and specific optical immunosensor for the detection of the dengue nonstructural protein 1 (NS1) biomarker in clinical samples obtained during early stages of infection. The present optical NS1 immunosensor comprises a biosensing surface consisting of specific monoclonal NS1 antibody for immunofluorescence-based NS1 antigen determination using fluorescein isothiocyanate (FITC) conjugated to IgG antibody...
November 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
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