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https://www.readbyqxmd.com/read/28728201/-fever-and-headache-after-a-vacation-in-thailand
#1
Benedikt Schwermer, Daniel Eschle, Constantine Bloch-Infanger
History 50 year-old man with fever and headache starting one week after returning from his vacation in Thailand. His general practitioner prescribed amoxicillin/clavulanic acid, without further analyses to pinpoint the infection. Examinations The examination of cerebro-spinal fluid was crucial for the final diagnosis. Lumbar puncture demonstrated a predominantly mononuclear pleocytosis of 80 cells/µl (< 5) with an elevated protein of 782 mg/l (< 450); glucose and lactate were within normal limits...
July 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28724764/rab5-and-rab11-are-required-for-clathrin-dependent-endocytosis-of-japanese-encephalitis-virus-in-bhk-21-cells
#2
Chun-Chun Liu, Yun-Na Zhang, Zhao-Yao Li, Jin-Xiu Hou, Jing Zhou, Lin Kan, Bin Zhou, Pu-Yan Chen
During infection Japanese Encephalitis Virus generally enters host cells via receptor-mediated clathrin dependent endocytosis. The trafficking of JEV within endosomes is controlled by Rab GTPases, but which Rab proteins are involved in JEV entry into BHK-21 cells is unknown. In this study, entry and post-internalization of JEV were analyzed using biochemical inhibitors, RNA interference and dominant negative mutants. Our data demonstrate that JEV entry into BHK-21 cells depends on clathrin, dynamin, and cholesterol, but not caveolae or macropinocytosis...
July 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28717094/limbic-encephalitis-associated-with-human-herpesvirus-7-hhv-7-in-an-immunocompetent-adult-the-first-reported-case-in-japan
#3
Yoko Aburakawa, Takayuki Katayama, Tsukasa Saito, Jun Sawada, Tatsuo Suzutani, Hitoshi Aizawa, Naoyuki Hasebe
A 35-year-old male who had not previously suffered any major illnesses was admitted to our hospital because of general fatigue, fever, headache, vomiting, consciousness disturbance, and seizures. A neurological examination showed that he was in a semi-comatose state and exhibited neck stiffness. Brain magnetic resonance imaging detected high-intensity areas in the bilateral hippocampi and periventricular white matter. A cerebrospinal fluid examination revealed mononuclear pleocytosis, an elevated protein level, and positivity for human herpesvirus-7 (HHV-7) DNA...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28716891/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-the-path-to-a-dengue-vaccine-learning-from-human-natural-dengue-infection-studies-and-vaccine-trials
#4
Aravinda M de Silva, Eva Harris
Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of partial immunity enhancing dengue disease severity. Several live attenuated dengue vaccines are being tested in human clinical trials. Initial results are mixed, with variable efficacy depending on DENV serotype and previous DENV exposure...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28710958/japanese-encephalitis-virus-counteracts-bst2-restriction-via-its-envelope-protein-e
#5
Mei Li, Ping Wang, Zifeng Zheng, Kai Hu, Mudan Zhang, Xinmeng Guan, Ming Fu, Di Zhang, Wei Wang, Gengfu Xiao, Qinxue Hu, Yalan Liu
It has been well documented that BST2 restricts the release of enveloped viruses by cross-linking newly produced virions to the cell membrane. However, it is less clear whether and how BST2 inhibits the release of enveloped viruses which bud via the secretory pathway. Here, we demonstrated that BST2 restricts the release of Japanese encephalitis virus (JEV) whose budding occurs at the ER-Golgi intermediate compartment, and in turn, JEV infection downregulates BST2 expression. We further found that the JEV envelope protein E, but not other viral components, significantly downregulates BST2 with the viral protein M playing an auxiliary role in the process...
July 12, 2017: Virology
https://www.readbyqxmd.com/read/28705180/etiology-and-prognosis-of-acute-viral-encephalitis-and-meningitis-in-chinese-children-a-multicentre-prospective-study
#6
Junhong Ai, Zhengde Xie, Gang Liu, Zongbo Chen, Yong Yang, Yuning Li, Jing Chen, Guo Zheng, Kunling Shen
BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28693301/serological-and-molecular-epidemiology-of-japanese-encephalitis-virus-infections-in-swine-herds-in-china-2006-2012
#7
Chunxia Chai, Qiao Wang, Sanjie Cao, Qin Zhao, Yiping Wen, Xiaobo Huang, Xintian Wen, Qiguai Yan, Xiaoping Ma, Rui Wu
Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing viral encephalitis in humans and reproductive disorder in pig. JEV is widely prevalent throughout China in human, however, studies on JEV spatiotemporal analysis in Chinese swine herds have not been explored. Here, we present our serological and molecular epidemiological findings of the prevalence of JEV infections among swine herds in China, which suggest that JEV infections are extensively widespread and genotype I and III strains co-exist...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28690034/interplay-of-inflammatory-gene-expression-in-pericytes-following-japanese-encephalitis-virus-infection
#8
Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Yu-Hui Hu, Ching-Yi Lai, Chen-Jung Chang, Chun-Jung Chen
Neuroinflammation is a pathological hallmark and has been implicated in the pathogenesis of Japanese encephalitis. Although brain pericytes show regulatory effects on neuroinflammation, their involvement in Japanese encephalitis-associated neuroinflammation is not understood. Here, we demonstrated that brain microvascular pericytes could be an alternative cellular source for the induction and/or amplification of neuroinflammation caused by Japanese encephalitis virus (JEV) infection. Infection of cultured pericytes with JEV caused profound production of IL-6, RANTES, and prostaglandin E2 (PGE2)...
July 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28680856/sertoli-cells-are-susceptible-to-zikv-infection-in-mouse-testis
#9
Zi-Yang Sheng, Na Gao, Zhao-Yang Wang, Xiao-Yun Cui, De-Shan Zhou, Dong-Ying Fan, Hui Chen, Pei-Gang Wang, Jing An
Flaviviruses including Dengue virus (DENV), Yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) are global health problems that caused several serious diseases such as fever, hemorrhagic fever, and encephalitis in the past century. Recently, Zika virus (ZIKV) which spreads from Asia to American and causes millions of infections emerges as a new dangerous member of the genus of Flavivirus. Unlike other well-known flaviviruses, ZIKV can be transmitted sexually and infect testes in murine models...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28680855/p21-activated-kinase-4-signaling-promotes-japanese-encephalitis-virus-mediated-inflammation-in-astrocytes
#10
Wen He, Zikai Zhao, Awais Anees, Yunchuan Li, Usama Ashraf, Zheng Chen, Yunfeng Song, Huanchun Chen, Shengbo Cao, Jing Ye
Japanese encephalitis virus (JEV) targets central nervous system, resulting in neuroinflammation with typical features of neuronal death along with hyper activation of glial cells. Exploring the mechanisms responsible for the JEV-caused inflammatory response remains a pivotal area of research. In the present study, we have explored the function of p21-activated kinase 4 (PAK4) in JEV-mediated inflammatory response in human astrocytes. The results showed that JEV infection enhances the phosphorylation of PAK4 in U251 cells and mouse brain...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28680381/exacerbation-of-japanese-encephalitis-by-cd11c-hi-dendritic-cell-ablation-is-associated-with-an-imbalance-in-regulatory-foxp3-and-il-17-cd4-th17-cells-and-in-ly-6c-hi-and-ly-6c-lo-monocytes
#11
Jin Young Choi, Jin Hyoung Kim, Ajit Mahadev Patil, Seong Bum Kim, Erdenebelig Uyangaa, Ferdaus Mohd Altaf Hossain, Seong Kug Eo
Japanese encephalitis (JE) is neuroinflammation characterized by uncontrolled infiltration of peripheral leukocytes into the central nervous system (CNS). We previously demonstrated exacerbation of JE following CD11c(hi) dendritic cell (DC) ablation in CD11c-DTR transgenic mice. Moreover, CD11c(hi) DC ablation led to abnormal differentiation of CD11b(+)Ly-6C(hi) monocytes and enhanced permeability of the blood-brain barrier (BBB), resulting in promoting the progression of JE. Here, we examined changes in lymphoid and myeloid-derived leukocyte subpopulations associated with pro- and anti-inflammation during JE progression...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28673857/development-and-application-of-a-reverse-transcriptase-droplet-digital-pcr-rt-ddpcr-for-sensitive-and-rapid-detection-of-japanese-encephalitis-virus
#12
Xulong Wu, Hua Lin, Shijie Chen, Lu Xiao, Miao Yang, Wei An, Yin Wang, Xueping Yao, Zexiao Yang
Japanese encephalitis (JE) is one of the most common zoonoses caused by Japanese encephalitis virus (JEV). Droplet digital PCR (ddPCR) is a novel sensitive, accurate method that enables absolute quantitation without the need for calibration curves. The aim of this study was to develop a RT-ddPCR method to detect JEV, and to compare its sensitivity with real-time TaqMan RT-PCR by analysis of clinical samples. The methods of JEV real-time RT-PCR and RT-ddPCR were established and optimal reaction conditions were confirmed...
June 30, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28672958/mir-16-1-expression-heat-shock-protein-70-and-inflammatory-reactions-in-astrocytes-of-mice-with-epilepsy-induced-by-encephalitis-b-virus-infection
#13
Yue Yao, Yujia Yang, Xuehua He, Xia Wang
The upregulation of miR-16-1 expression and heat shock protein 70 (HSP70) and inflammatory reaction mechanism in astrocytes of mice with epilepsy induced by encephalitis B virus infection were studied. Six-to-eight-week-old healthy male C57BL/6 mice received intraperitoneal injection of pilocarpine (320-340 mg/kg, 40 mg/ml) to induce status epilepsy. After 7 days, mice were inoculated with 100 µl Dulbecco's modified Eagle's medium (DMEM) in the neck, including 6.25×23 PFU Japanese encephalitis virus P3 wild strain...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28671301/detection-of-long-term-cellular-immune-response-to-japanese-encephalitis-vaccination-using-ifn-%C3%AE-elispot-assay
#14
Amreen Zia, Dharamveer Singh, Swati Saxena, Jyoti Umrao, Manjari Baluni, Sneha Ghildiyal, Tanzeem Fatima, Mukti Shukla, Vikas Agarwal, Tapan N Dhole
Vaccine is the most effective preventive measure against Japanese Encephalitis infection. Role of IFN-γ expressing T cells for JE virus clearance has been described as a part of cellular immunity. Vaccine induced immunity also involve the cellular immune response, therefore the study was aimed to observe induction and persistence of IFN-γ expressing T cells by IFN-γ ELISpot assay. The cell count increased significantly after 28 (p < 0.0001) days post vaccination, and remained higher at all time points (day 28, day 180, day 360) when compared with prevaccination...
July 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28666583/pathophysiological-mechanisms-of-flavivirus-infection-of-the-central-nervous-system
#15
N Pardigon
Flaviviruses are important human pathogens. Transmitted by the bite of infected mosquitoes, Flaviviruses such as West Nile and Japanese encephalitis may reach the central nervous system where they can elicit severe diseases. Their ability to cross the blood-brain-barrier is still poorly understood. The newly emerging Zika Flavivirus on the other hand very rarely reaches the brain of adults, but can infect neural progenitors in the developing central nervous system of fetuses, eliciting devastating congenital malformations including microcephaly...
June 27, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28656253/heat-shock-protein-90%C3%AE-in-the-vero-cell-membrane-binds-japanese-encephalitis-virus
#16
Yuan Wang, Yan Li, Tianbing Ding
The pathogenesis of Japanese encephalitis virus (JEV) is complex and unclearly defined, and in particular, the effects of the JEV receptor (JEVR) on diverse susceptible cells are elusive. In contrast to previous studies investigating JEVR in rodent or mosquito cells, in this study, we used primate Vero cells instead. We noted that few novel proteins co‑immunoprecipitated with JEV, and discovered that one of these was heat shock protein 90β (HSP90β), which was probed by mass spectrometry with the highest score of 60...
June 26, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28640796/erratum-vol-66-no-22
#17
(no author information available yet)
In the report "Japanese Encephalitis Surveillance and Immunization - Asia and Western Pacific Regions, 2016," on page 581, in the table "Characteristics of Japanese encephalitis (JE) surveillance in countries with JE virus transmission risk, 2016," and on page 582, in the table "Characteristics of Japanese encephalitis (JE) immunization programs in countries with JE virus transmission risk, 2016," Taiwan should have been indented beneath China. The corrected tables with added indents can be found at http://apps...
June 23, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28627955/herpes-simplex-encephalitis-with-thalamic-brainstem-and-cerebellar-involvement
#18
Meenal Garg, Shilpa Kulkarni, Anaita Udwadia Hegde
Herpes simplex virus encephalitis is a common and treatable cause of acute encephalitis in all age groups. Certain radiological features such as temporal parenchymal involvement facilitate the diagnosis. The use of herpes simplex virus polymerase chain reaction has expanded the clinical and imaging spectrum. We report the case of a young patient who presented with a movement disorder and predominant involvement of thalami, brainstem and cerebellum on magnetic resonance imaging, and was diagnosed with herpes simplex virus encephalitis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28619100/cyclophilin-b-facilitates-the-replication-of-orf-virus
#19
Kui Zhao, Jida Li, Wenqi He, Deguang Song, Ximu Zhang, Di Zhang, Yanlong Zhou, Feng Gao
BACKGROUND: Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly up-regulated. Recently, a number of studies have shown that CypB is important in the replication of several viruses, including Japanese encephalitis virus (JEV), hepatitis C virus (HCV) and human papillomavirus type 16 (HPV 16). However, the function of cellular CypB in ORFV replication has not yet been explored...
June 15, 2017: Virology Journal
https://www.readbyqxmd.com/read/28615847/larvicidal-potency-of-marine-actinobacteria-isolated-from-mangrove-environment-against-aedes-aegypti-and-anopheles-stephensi
#20
S Balakrishnan, P Santhanam, M Srinivasan
The marine soil samples were collected from different locations of Parangipettai mangrove ecosystem, Vellar estuary, southeast coast of India. Totally 30 different marine actinobacteria were isolated by serial dilution plate technique on starch casein agar medium. The isolated actinobacteria were investigated for their larvicidal activity against Aedes aegypti and Anopheles stephensi mosquitoes. Streptomyces fungicidicus, S. griseus, S. albus, S. alboflavus and S. rochei were identified as potential biocide producers...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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