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https://www.readbyqxmd.com/read/28943565/mild-encephalitis-encephalopathy-with-a-reversible-splenial-lesion-in-an-adult-patient-with-influenza
#1
Hana Takatsu, Naoto Ishimaru, Madoka Ito, Saori Kinami
We herein report the case of a 31-year-old Japanese woman who developed adult-onset clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and presented with consciousness disorder and olfactory disturbance secondary to influenza A infection. The patient's neurological symptoms and the lesion in the splenium resolved within 14 days without therapy. Magnetic resonance images and the clinical course were consistent with a diagnosis of MERS; however, mental changes following the influenza infection always present a diagnostic dilemma for physicians...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28938099/plasmid-dna-launches-live-attenuated-japanese-encephalitis-virus-and-elicits-virus-neutralizing-antibodies-in-balb-c-mice
#2
Brian Nickols, Irina Tretyakova, Alexander Tibbens, Elena Klyushnenkova, Peter Pushko
We describe novel plasmid DNA that encodes the full-length Japanese encephalitis virus (JEV) genomic cDNA and launches live-attenuated JEV vaccine in vitro and in vivo. The synthetic cDNA based on the sequence of JEV SA14-14-2 live-attenuated virus was placed under transcriptional control of the cytomegalovirus major immediate-early promoter. The stability and yields of the plasmid in E. coli were optimized by inserting three synthetic introns that disrupted JEV cDNA in the structural and nonstructural genes...
September 19, 2017: Virology
https://www.readbyqxmd.com/read/28934970/isolation-and-identification-of-xenorhabdus-and-photorhabdus-bacteria-associated-with-entomopathogenic-nematodes-and-their-larvicidal-activity-against-aedes-aegypti
#3
Chamaiporn Fukruksa, Thatcha Yimthin, Manawat Suwannaroj, Paramaporn Muangpat, Sarunporn Tandhavanant, Aunchalee Thanwisai, Apichat Vitta
BACKGROUND: Aedes aegypti is a potential vector of West Nile, Japanese encephalitis, chikungunya, dengue and Zika viruses. Alternative control measurements of the vector are needed to overcome the problems of environmental contamination and chemical resistance. Xenorhabdus and Photorhabdus are symbionts in the intestine of entomopathogenic nematodes (EPNs) Steinernema spp. and Heterorhabditis spp. These bacteria are able to produce a broad range of bioactive compounds including antimicrobial, antiparasitic, cytotoxic and insecticidal compounds...
September 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28934431/genetic-profiling-and-comorbidities-of-zika-infection
#4
Mohammad Ali Moni, Pietro Lio'
Background: The difficulty in distinguishing infection by Zika virus (ZIKV) from other flaviviruses is a global health concern, particularly given the high risk of neurologic complications (including Guillain-Barré syndrome [GBS]) with ZIKV infection. Methods: We developed quantitative frameworks to compare and explore infectome, diseasome, and comorbidity of ZIKV infections. We analyzed gene expression microarray and RNA-Seq data from ZIKV, West Nile fever (WNF), chikungunya, dengue, yellow fever, Japanese encephalitis virus, GBS, and control datasets...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934197/updated-estimation-of-the-impact-of-a-japanese-encephalitis-immunization-program-with-live-attenuated-sa-14-14-2-vaccine-in-nepal
#5
Shyam Raj Upreti, Nicole P Lindsey, Rajendra Bohara, Ganga Ram Choudhary, Sushil Shakya, Mukunda Gautam, Jagat Narain Giri, Marc Fischer, Susan L Hills
BACKGROUND: Japanese encephalitis (JE) is a mosquito-borne disease that is associated with considerable morbidity and mortality in many Asian countries. The objective of this study was to describe the impact of the JE immunization program using SA 14-14-2 JE vaccine implemented in Nepal during 2006 through 2011. A previous assessment after the initial program implementation phase described a significantly lower post-campaign JE incidence compared to expected incidence; however, the previous evaluation had limited post-campaign data for some districts...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28930529/a-protocol-for-investigating-the-association-of-vaccination-and-anti-nmda-receptor-encephalitis
#6
Hsiuying Wang
Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis is an acute autoimmune neurological disorder that can be triggered by virus, H1N1/tetanus/diphtheria/pertussis and polio vaccines or by presence of a tumor. The association between anti-NMDA receptor encephalitis and Japanese encephalitis vaccination was examined and a general protocol of phylogenetic method which details the steps and code and an example of its utility is provided. The approach used here is potentially useful for analyzing the relationship between vaccines and diseases...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28916719/kir2ds2-recognizes-conserved-peptides-derived-from-viral-helicases-in-the-context-of-hla-c
#7
Mohammed M Naiyer, Sorcha A Cassidy, Andrea Magri, Vanessa Cowton, Kevin Chen, Salah Mansour, Hariklia Kranidioti, Berenice Mbirbindi, Pauline Rettman, Scott Harris, Liam J Fanning, Arend Mulder, Franz H J Claas, Andrew D Davidson, Arvind H Patel, Marco A Purbhoo, Salim I Khakoo
Killer cell immunoglobulin-like receptors (KIRs) are rapidly evolving species-specific natural killer (NK) cell receptors associated with protection against multiple different human viral infections. We report that the activating receptor KIR2DS2 directly recognizes viral peptides derived from conserved regions of flaviviral superfamily 2 RNA helicases in the context of major histocompatibility complex class I. We started by documenting that peptide LNPSVAATL from the hepatitis C virus (HCV) helicase binds HLA-C*0102, leading to NK cell activation through engagement of KIR2DS2...
September 15, 2017: Science Immunology
https://www.readbyqxmd.com/read/28904127/therapeutic-effects-of-monoclonal-antibody-against-dengue-virus-ns1-in-a-stat1-knockout-mouse-model-of-dengue-infection
#8
Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin
Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome and is endemic to tropical and subtropical regions of the world. Our previous studies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive with host Ags and trigger anti-DENV NS1 Ab-mediated endothelial cell damage and platelet dysfunction. To circumvent these potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding region from Japanese encephalitis virus NS1 to create chimeric DJ NS1 protein...
September 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28883984/the-changing-epidemiology-of-japanese-encephalitis-and-new-data-the-implications-for-new-recommendations-for-japanese-encephalitis-vaccine
#9
REVIEW
Bradley Connor, William B Bunn
The epidemiology of Japanese Encephalitis and risk to the traveler has changed and continues to evolve. The spread of Japanese Encephalitis virus into new environments, changes in agricultural practice and animal vectors, climate change, peri-urban growth, changes in international travel to Asia, personal risk factors, mosquito vector free transmission, interactions with other flaviviruses and better information on infections without encephalitis and other factors make Japanese Encephalitis an underappreciated risk...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28882174/molecular-phylogeny-of-anopheles-hyrcanus-group-members-based-on-its2-rdna
#10
Yuan Fang, Wen-Qi Shi, Yi Zhang
BACKGROUND: The Anopheles hyrcanus group includes 25 species, and is widely distributed in the Oriental and Palaearctic regions. Several species within this group are vectors of malaria, lymphatic filariasis and Japanese encephalitis. It is difficult or impossible to identify cryptic species based on their morphological characteristics, with some closely related species of the Hyrcanus Group have similar adult morphological characteristics. Thus, their molecular identification has been an important complementary method to traditional morphological taxonomy...
September 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28882172/meta-analyses-of-the-proportion-of-japanese-encephalitis-virus-infection-in-vectors-and-vertebrate-hosts
#11
Ana R S Oliveira, Lee W Cohnstaedt, Erin Strathe, Luciana Etcheverry Hernández, D Scott McVey, José Piaggio, Natalia Cernicchiaro
BACKGROUND: Japanese encephalitis (JE) is a zoonosis in Southeast Asia vectored by mosquitoes infected with the Japanese encephalitis virus (JEV). Japanese encephalitis is considered an emerging exotic infectious disease with potential for introduction in currently JEV-free countries. Pigs and ardeid birds are reservoir hosts and play a major role on the transmission dynamics of the disease. The objective of the study was to quantitatively summarize the proportion of JEV infection in vectors and vertebrate hosts from data pertaining to observational studies obtained in a systematic review of the literature on vector and host competence for JEV, using meta-analyses...
September 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28881548/-quality-of-case-report-of-japanese-encephalitis-after-the-establishment-of-surveillance-on-acute-meningitis-and-encephalitis-syndrome-in-baoji
#12
W J Hu, X Y Liu, Y Q Wang, S B Zhang
Objective: To evaluate the quality of Japanese Encephalitis (JE) case reports based on the establishment of surveillance on acute meningitis and encephalitis syndrome (AMES) in Baoji. Methods: A surveillance network on AMES cases was set up in Baoji city of Shaanxi province between July 2013 and December 2016. All the cases met the surveillance definition of AMES cases were conducted a questionnaire, collected serum and/or cerebrospinal fluid (CSF) specimens to test JE immunoglobulin M antibodies by using enzyme-linkedimmunosorbent assay methods...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28876040/-secreted-expression-of-japanese-encephalitis-virus-prme-in-pichia-pastoris-and-immunogenicity-evaluation-of-the-virus-like-particles-in-mice
#13
Peng Zhao, Ya Jiang, Jingman Wang, Haojie Fan, Ruibing Cao
The study was to express prME protein of Japanese encephalitis virus (JEV) in Pichia pastoris and then to evaluate the immunological properties of the recombinant protein in mice, so as to explore a new way for subunit vaccine development of JEV. The JEV prME gene was amplified by RT-PCR with genome RNA of JEV vaccine strain SA14-14-2 and subcloned into pPICZa-A vector, designated as pPICZα-prME. pPICZα-SprME was constructed same as pPICZα-prME besides with the additional 19 Aa signal peptides coding gene of the JEV cap protein C terminal...
May 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#14
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
September 5, 2017: Intervirology
https://www.readbyqxmd.com/read/28867843/estimated-economic-impact-of-vaccinations-in-73-low-and-middle-income-countries-2001-2020
#15
Sachiko Ozawa, Samantha Clark, Allison Portnoy, Simrun Grewal, Meghan L Stack, Anushua Sinha, Andrew Mirelman, Heather Franklin, Ingrid K Friberg, Yvonne Tam, Neff Walker, Andrew Clark, Matthew Ferrari, Chutima Suraratdecha, Steven Sweet, Sue J Goldie, Tini Garske, Michelle Li, Peter M Hansen, Hope L Johnson, Damian Walker
OBJECTIVE: To estimate the economic impact likely to be achieved by efforts to vaccinate against 10 vaccine-preventable diseases between 2001 and 2020 in 73 low- and middle-income countries largely supported by Gavi, the Vaccine Alliance. METHODS: We used health impact models to estimate the economic impact of achieving forecasted coverages for vaccination against Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella, Streptococcus pneumoniae and yellow fever...
September 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28867626/enhanced-cytopathic-effect-of-japanese-encephalitis-virus-strain-sa14-14-2-probable-association-of-mutation-in-amino-acid-of-its-envelope-protein
#16
Barnali Nath, Ashutosh Gupta, Siraj A Khan, Sachin Kumar
Japanese encephalitis (JE) is a mosquito-borne viral disease. It is a global public health concern since it causes an acute encephalitis syndrome (AES). A large number of JE/AES cases are reported to occur in areas with established or developing JE vaccination program. Partial vaccine coverage and emergence of new variants of Japanese encephalitis virus (JEV) might be playing an important role. The envelope protein (E) of JEV is a major antigenic determinant and responsible for immunogenic responses as well as membrane fusion and virion assembly...
September 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28865242/novel-graphene-based-biosensor-for-early-detection-of-zika-virus-infection
#17
Savannah Afsahi, Mitchell B Lerner, Jason M Goldstein, Joo Lee, Xiaoling Tang, Dennis A Bagarozzi, Deng Pan, Lauren Locascio, Amy Walker, Francie Barron, Brett R Goldsmith
We have developed a cost-effective and portable graphene-enabled biosensor to detect Zika virus with a highly specific immobilized monoclonal antibody. Field Effect Biosensing (FEB) with monoclonal antibodies covalently linked to graphene enables real-time, quantitative detection of native Zika viral (ZIKV) antigens. The percent change in capacitance in response to doses of antigen (ZIKV NS1) coincides with levels of clinical significance with detection of antigen in buffer at concentrations as low as 450pM...
August 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28865053/dc-sign-promotes-japanese-encephalitis-virus-transmission-from-dendritic-cells-to-t-cells-via-virological-synapses
#18
Ping Wang, Mei Li, Wei Lu, Di Zhang, Qinxue Hu, Yalan Liu
Skin-resident dendritic cells (DCs) likely encounter incoming viruses in the first place, and their migration to lymph nodes following virus capture may promote viral replication. However, the molecular mechanisms underlying these processes remain unclear. In the present study, we found that compared to cell-free viruses, DC-bound viruses showed enhanced capture of JEV by T cells. Additionally, JEV infection was increased by co-culturing DCs and T cells. Blocking the C-type lectin receptor DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) with neutralizing antibodies or antagonists blocked JEV transmission to T cells...
August 31, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28860941/dengue-virus-and-japanese-encephalitis-virus-infection-of-the-central-nervous-system-share-similar-profiles-of-cytokine-accumulation-in-cerebrospinal-fluid
#19
Haipeng Li, Yuanyuan Li, Bo Wen, Jian Zhang, Chengwu Wang, Zhanyi Song, Shuochi Li, Xiaowang Qu, Renbin Huang, Wenpei Liu
Dengue virus (DENV) and Japanese encephalitis virus (JEV) are two important pathogenic viruses that can cause severe encephalitis, which is accompanied by inflammatory cytokines. However, the inflammatory cytokine content of cerebrospinal fluid (CSF) in DENV and JEV infection of central nervous system are not sufficiently studied. To investigate cytokine levels in serum and CSF of hospitalised children with DENV and JEV infection of the central nervous system, a total of 183 hospitalised children with viral encephalitis-like syndrome were enrolled between May 2014 and April 2015 at the Children's Hospital of Chenzhou, Hunan, China...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28852181/enrichment-of-viral-nucleic-acids-by-solution-hybrid-selection-with-genus-specific-oligonucleotides
#20
Andrei A Deviatkin, Alexander N Lukashev, Mikhail M Markelov, Larisa V Gmyl, German A Shipulin
Despite recent advances, our knowledge of potential and rare human pathogens is far from exhaustive. Current molecular diagnostic tools mainly rely on the specific amplification of marker sequences and may overlook infections caused by unknown and rare pathogens. Using high-throughput sequencing (HTS) can solve this problem; but, due to the extremely low fraction of pathogen genetic material in clinical samples, its application is only cost-effective in special, rather than routine, cases. In this study, we present a method for the semi-specific enrichment of viral conservative sequences in a HTS library by hybridization in solution with genus-specific degenerate biotinylated oligonucleotides...
August 29, 2017: Scientific Reports
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