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https://www.readbyqxmd.com/read/28542435/development-and-evaluation-of-a-bioinformatics-approach-for-designing-molecular-assays-for-viral-detection
#1
Pierre H H Schneeberger, Joël F Pothier, Andreas Bühlmann, Brion Duffy, Christian Beuret, Jürg Utzinger, Jürg E Frey
BACKGROUND: Viruses belonging to the Flaviviridae and Bunyaviridae families show considerable genetic diversity. However, this diversity is not necessarily taken into account when developing diagnostic assays, which are often based on the pairwise alignment of a limited number of sequences. Our objective was to develop and evaluate a bioinformatics workflow addressing two recurrent issues of molecular assay design: (i) the high intraspecies genetic diversity in viruses and (ii) the potential for cross-reactivity with close relatives...
2017: PloS One
https://www.readbyqxmd.com/read/28536430/aetiology-of-acute-meningoencephalitis-in-cambodian-children-2010-2013
#2
Paul F Horwood, Veasna Duong, Denis Laurent, Channa Mey, Heng Sothy, Ky Santy, Beat Richner, Seiha Heng, Sopheak Hem, Justine Cheval, Christopher Gorman, Philippe Dussart, Menno D de Jong, Alexandra Kerleguer, Bertrand Guillard, Bernadette Murgue, Marc Lecuit, Xavier de Lamballerie, Jeremy J Farrar, Arnaud Tarantola, Marc Eloit, Philippe Buchy
Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV)...
May 24, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28535855/japanese-encephalitis-virus-activates-autophagy-through-xbp1-and-atf6-er-stress-sensors-in-neuronal-cells
#3
Manish Sharma, Sankar Bhattacharyya, Kiran Bala Sharma, Shailendra Chauhan, Suramya Asthana, Malik Zainul Abdin, Sudhanshu Vrati, Manjula Kalia
Endoplasmic reticulum (ER) stress and autophagy are key cellular responses to RNA virus infection. Recent studies have shown that Japanese encephalitis virus (JEV)-induced autophagy negatively influences virus replication in mouse neuronal cells and embryonic fibroblasts, and delays virus-induced cell death. Here, we evaluated the role of ER stress pathways in inducing autophagy during JEV infection. We observed that JEV infection of neuronal cells led to activation of all three sensors of ER stress mediated by eIF2α/PERK, IRE1/XBP1 and ATF6...
May 23, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28535637/-analysis-of-prodromal-phase-and-prodromal-events-in-anti-n-methyl-d-aspartate-receptor-encephalitis
#4
Y Yao, B Peng, X H Wang, F Fang, D Xu, X L Xu, H T Ren, Y C Zhu, L Y Cui, H Z Guan
Objective: To analyze prodromal phase and prodromal events of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods: Clinical data of 179 patients hospitalized and diagnosed during 2010-2016 including adults and children in Peking Union Medical College Hospital and Beijing Children's Hospital were collected.Patients with prodromal phase or prodromal events were selected.A retrospective analysis of clinical characteristics including prodromal phase or prodromal events, course of disease, brain imaging, laboratory results and therapeutic effect was performed...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28531165/a-japanese-encephalitis-virus-vaccine-inducing-antibodies-strongly-enhancing-in-vitro-infection-is-protective-in-pigs
#5
Obdulio García-Nicolás, Meret E Ricklin, Matthias Liniger, Nathalie J Vielle, Sylvie Python, Philippe Souque, Pierre Charneau, Artur Summerfield
The Japanese encephalitis virus (JEV) is responsible for zoonotic severe viral encephalitis transmitted by Culex mosquitoes. Although birds are reservoirs, pigs play a role as amplifying hosts, and are affected in particular through reproductive failure. Here, we show that a lentiviral JEV vector, expressing JEV prM and E proteins (TRIP/JEV.prME), but not JEV infection induces strong antibody-dependent enhancement (ADE) activities for infection of macrophages. Such antibodies strongly promoted infection via Fc receptors...
May 22, 2017: Viruses
https://www.readbyqxmd.com/read/28528139/occurrence-of-old-age-japanese-encephalitis-current-situation-in-taiwan
#6
Ying-Hui Wu, Jer-Min Chen, Chen-Yi Su
No abstract text is available yet for this article.
May 17, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28518046/epidemiologic-survey-of-japanese-encephalitis-virus-infection-tibet-china-2015
#7
Hui Zhang, Mujeeb Ur Rehman, Kun Li, Houqiang Luo, Yanfang Lan, Fazul Nabi, Lihong Zhang, Muhammad Kashif Iqbal, Suolangsi Zhu, Muhammad Tariq Javed, Yangzom Chamba, Jia Kui Li
We investigated Japanese encephalitis virus (JEV) prevalence in high-altitude regions of Tibet, China, by using standard assays to test mosquitoes, pigs, and humans. Results confirmed that JEV has spread to these areas. Disease prevention and control strategies should be used along with surveillance to limit spread of JEV in high-altitude regions of Tibet.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28515719/production-of-japanese-encephalitis-virus-antigens-in-plants-using-bamboo-mosaic-virus-based-vector
#8
Tsung-Hsien Chen, Chung-Chi Hu, Jia-Teh Liao, Yi-Ling Lee, Ying-Wen Huang, Na-Sheng Lin, Yi-Ling Lin, Yau-Heiu Hsu
Japanese encephalitis virus (JEV) is among the major threats to public health in Asia. For disease control and prevention, the efficient production of safe and effective vaccines against JEV is in urgent need. In this study, we produced a plant-made JEV vaccine candidate using a chimeric virus particle (CVP) strategy based on bamboo mosaic virus (BaMV) for epitope presentation. The chimeric virus, designated BJ2A, was constructed by fusing JEV envelope protein domain III (EDIII) at the N-terminus of BaMV coat protein, with an insertion of the foot-and-mouth disease virus 2A peptide to facilitate the production of both unfused and epitope-presenting for efficient assembly of the CVP vaccine candidate...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28509619/japanese-encephalitis-virus-infection-rate-and-detection-of-genotype-i-from-culex-tritaeniorhynchus-collected-from-jiangsu-china
#9
Hongliang Chu, Zhiming Wu, Hongna Chen, Chunxiao Li, Xiaoxia Guo, Ran Liu, Gang Wang, Minghao Zhou, Tongyan Zhao
Information regarding the infection rate and genotype shifts for Japanese encephalitis virus (JEV) are important for JE vaccine application. In Jiangsu province, China, which is one of the provinces with a high prevalence of JE, JEV infection in swine and mosquitoes in certain cities has only been investigated in 2008-2009. Lianyungang City has one of the highest numbers of JE cases in Jiangsu province, and it has a high risk of JEV invasion via migrant birds. JEV infection in vectors in Lianyungang City, which has urban and rural parts, has not been investigated...
May 16, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28506240/inhibitors-compounds-of-the-flavivirus-replication-process
#10
REVIEW
Leidy L García, Leonardo Padilla, Jhon C Castaño
Flaviviruses are small viruses with single-stranded RNA, which include the yellow fever virus, dengue virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus; and are causal agents of the most important emerging diseases that have no available treatment to date. In recent years, the strategy has focused on the development of replication inhibitors of these viruses designed to act mainly by affecting the activity of enzyme proteins, such as NS3 and NS5, which perform important functions in the viral replication process...
May 15, 2017: Virology Journal
https://www.readbyqxmd.com/read/28505314/diversity-of-mosquitoes-diptera-culicidae-attracted-to-human-subjects-in-rubber-plantations-secondary-forests-and-villages-in-luang-prabang-province-northern-lao-pdr
#11
Julie-Anne A Tangena, Phoutmany Thammavong, Naritsara Malaithong, Thavone Inthavong, Phuthasone Ouanesamon, Paul T Brey, Steve W Lindsay
The impact of the rapid expansion of rubber plantations in South-East Asia on mosquito populations is uncertain. We compared the abundance and diversity of adult mosquitoes using human-baited traps in four typical rural habitats in northern Lao PDR: secondary forests, immature rubber plantations, mature rubber plantations, and villages. Generalized estimating equations were used to explore differences in mosquito abundance between habitats, and Simpson's diversity index was used to measure species diversity...
May 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28501474/a-case-of-mumps-related-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#12
Kyoko Hazama, Takashi Shiihara, Hiroyuki Tsukagoshi, Shunji Hasegawa, Yuri Dowa, Mio Watanabe
BACKGROUND: Mumps is a common childhood viral disease characterized by fever and swelling of the parotid gland. The prognosis is generally good, although some complications, such as encephalitis (0.1%), exist. Acute encephalopathy with biphasic seizures and late reduced diffusion is the most common type of acute encephalopathy. However, this type of encephalopathy has not been reported in association with mumps infection. PATIENT: A previously healthy 3-year-old Japanese boy had a brief convulsion after fever for 3days, and then had conscious disturbance and parotitis...
May 10, 2017: Brain & Development
https://www.readbyqxmd.com/read/28490339/distribution-and-phylogeny-of-wolbachia-strains-in-wild-mosquito-populations-in-sri-lanka
#13
N W Nalaka P Nugapola, W A Priyanka P De Silva, S H P Parakrama Karunaratne
BACKGROUND: Wolbachia are a group of maternally inherited intracellular bacteria known to be widespread among arthropods. Infections with Wolbachia cause declines of host populations, and also induce host resistance to a wide range of pathogens. Over the past few decades, researchers were curious to use Wolbachia as a biological tool to control mosquito vectors. During the present study, assessment of the prevalence of Wolbachia infections among wild mosquito populations in Sri Lanka where mosquito-borne diseases are a major health concern, was carried out for the first time...
May 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28480297/central-nervous-system-infection-diagnosis-by-next-generation-sequencing-a-glimpse-into-the-future
#14
Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Nguyen Ho Hong Hanh, Lam Anh Nguyet, Tran My Phuong, Angela McBride, Do Quang Ha, Ho Dang Trung Nghia, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan
Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28474625/immunogenicity-safety-of-a-single-dose-of-live-attenuated-japanese-encephalitis-vaccine-sa-14-14-2-in-adults
#15
Siraj Ahmed Khan, Sanjeeb Kakati, Prafulla Dutta, Purvita Chowdhury, Jani Borah, Rashmee Topno, Santoshkumar M Jadhav, Pradyumna K Mohapatra, Jagadish Mahanta, Mohan D Gupte
BACKGROUND & OBJECTIVES: Japanese encephalitis (JE) caused by mosquito-borne Flavivirus is one of the leading causes of viral encephalitis in Asia. Control strategies include vector control and human vaccination. Due to lack of immunization programmes in endemic regions, there are still high mortality and morbidity. A live-attenuated SA 14-14-2 JE vaccine (LAJEV) has been licensed and used in Asian countries, including India. We report the assessment of immunogenicity and safety of the vaccine in adults during the first mass adult vaccination campaign carried out in Assam, India...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28471403/pathogenesis-and-inhibition-of-flaviviruses-from-a-carbohydrate-perspective
#16
REVIEW
So Young Kim, Bing Li, Robert J Linhardt
Flaviviruses are enveloped, positive single stranded ribonucleic acid (RNA) viruses with various routes of transmission. While the type and severity of symptoms caused by pathogenic flaviviruses vary from hemorrhagic fever to fetal abnormalities, their general mechanism of host cell entry is similar. All pathogenic flaviviruses, such as dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, and Zika virus, bind to glycosaminglycans (GAGs) through the putative GAG binding sites within their envelope proteins to gain access to the surface of host cells...
May 4, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28470592/japanese-encephalitis-can-trigger-anti-n-methyl-d-aspartate-receptor-encephalitis
#17
Jiannan Ma, Ting Zhang, Li Jiang
Japanese encephalitis (JE) is usually a monophasic disease; however, in rare cases, patients with JE may have an early relapse after a partial recovery, giving rise to a biphasic pattern for the disease. In this study, we report three pediatric cases in which post-JE relapse was characterized by movement disorder and/or behavioral problems, and was related to anti-N-methyl-D-aspartate receptor (NMDAR) immunoglobulin G (IgG). Serum and cerebrospinal fluid were examined for anti-NMDAR IgG in three patients who had confirmed JE and then developed relapsing symptoms which were similar to those of anti-NMDAR encephalitis...
May 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28468311/tubacin-an-hdac6-selective-inhibitor-reduces-the-replication-of-the-japanese-encephalitis-virus-via-the-decrease-of-viral-rna-synthesis
#18
Chien-Yi Lu, Yi-Chih Chang, Chun-Hung Hua, Chieh Chuang, Su-Hua Huang, Szu-Hao Kung, Mann-Jen Hour, Cheng-Wen Lin
Japanese encephalitis virus (JEV), a neurotropic flavivirus, annually causes over 30,000 Japanese Encephalitis (JE) cases in East and Southeast Asia. Histone deacetylases (HDACs) modulate lysine acetylation of histones and non-histone proteins, regulating many processes including inflammation and antiviral immune response. This study investigated antiviral activity of pan- and selective-HDAC inhibitors as host-targeting agents against JEV. Among HDAC inhibitors, selective HDAC6 inhibitors (tubastatin-A (TBSA) and tubacin) concentration-dependently inhibited JEV-induced cytopathic effect and apoptosis, as well as reduced virus yield in human cerebellar medulloblastoma cells...
May 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28463989/identifying-sources-pathways-and-risk-drivers-in-ecosystems-of-japanese-encephalitis-in-an-epidemic-prone-north-indian-district
#19
Manish Kakkar, Sanjay Chaturvedi, Vijay Kumar Saxena, Tapan N Dhole, Ashok Kumar, Elizabeth T Rogawski, Syed Abbas, Vidya V Venkataramanan, Pranab Chatterjee
Japanese Encephalitis (JE) has caused repeated outbreaks in endemic pockets of India. This study was conducted in Kushinagar, a highly endemic district, to understand the human-animal-ecosystem interactions, and the drivers that influence disease transmission. Utilizing the ecosystems approach, a cross-sectional, descriptive study, employing mixed methods design was employed. Four villages (two with pig-rearing and two without) were randomly selected from a high, a medium and a low burden (based on case counts) block of Kushinagar...
2017: PloS One
https://www.readbyqxmd.com/read/28446752/near-atomic-structure-of-japanese-encephalitis-virus-reveals-critical-determinants-of-virulence-and-stability
#20
Xiangxi Wang, Shi-Hua Li, Ling Zhu, Qing-Gong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, Neil Shaw, Junzhi Wang, Thomas S Walter, Juha T Huiskonen, Elizabeth E Fry, Cheng-Feng Qin, David I Stuart, Zihe Rao
Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia. The structural and molecular basis of this encephalitis is not fully understood. Here, we report the cryo-electron microscopy structure of mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusual "hole" on the surface, surrounded by five encephalitic-specific motifs implicated in receptor binding. Glu138 of E, which is highly conserved in encephalitic flaviviruses, maps onto one of these motifs and is essential for binding to neuroblastoma cells, with the E138K mutation abrogating the neurovirulence and neuroinvasiveness of Japanese encephalitis virus in mice...
April 26, 2017: Nature Communications
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