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https://www.readbyqxmd.com/read/29782696/routine-antenatal-ultrasound-in-low-and-middle-income-countries-first-look-a-cluster-randomized-trial
#1
Robert L Goldenberg, Robert O Nathan, David Swanson, Sarah Saleem, Waseem Mirza, Fabian Esamai, David Muyodi, Ana L Garces, Lester Figueroa, Elwyn Chomba, Melody Chiwala, Musaku Mwenechanya, Antoinette Tshefu, Adrien Lokangako, Victor Lokomba Bolamba, Janet L Moore, Holly Franklin, Jonathan Swanson, Edward A Liechty, Carl L Bose, Nancy F Krebs, K Michael Hambidge, Waldemar A Carlo, Nancy Kanaiza, Farnaz Naqvi, Irma Sayury Pineda, Walter López-Gomez, Dorothy Hamsumonde, Margo S Harrison, Marion Koso-Thomas, Menachem Miodovnik, Dennis D Wallace, Elizabeth M McClure
OBJECTIVE: Ultrasound is widely regarded as an important adjunct to antenatal care (ANC) to guide practice and reduce perinatal mortality. We assessed the impact of ANC ultrasound use at health centers in resource-limited countries. DESIGN: Cluster randomized trial. SETTING: Clusters within five countries (Democratic Republic of Congo, Guatemala, Kenya, Pakistan and Zambia). METHODS: Clusters were randomized to standard ANC or standard care plus two ultrasounds and referral for complications...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29782511/prevalence-and-factors-associated-with-underutilization-of-antenatal-care-services-in-nigeria-a-comparative-study-of-rural-and-urban-residences-based-on-the-2013-nigeria-demographic-and-health-survey
#2
Emmanuel Olorunleke Adewuyi, Asa Auta, Vishnu Khanal, Olasunkanmi David Bamidele, Cynthia Pomaa Akuoko, Kazeem Adefemi, Samson Joseph Tapshak, Yun Zhao
INTRODUCTION: Antenatal care (ANC) is a major public health intervention aimed at ensuring safe pregnancy outcomes. In Nigeria, the recommended minimum of four times ANC attendance is underutilized. This study investigates the prevalence and factors associated with underutilization of ANC services with a focus on the differences between rural and urban residences in Nigeria. METHODS: We analyzed the 2013 Nigeria Demographic and Health Survey dataset with adjustment for the sampling weight and the cluster design of the survey...
2018: PloS One
https://www.readbyqxmd.com/read/29781684/husbands-participation-in-birth-preparedness-and-complication-readiness-and-associated-factors-in-wolaita-sodo-town-southern-ethiopia
#3
Minyahil Tadesse, Andualem T Boltena, Benedict O Asamoah
BACKGROUND:  The poor emphasis on the role of husbands in birth preparedness and complication readiness (BPCR) is a major factor that should be addressed in tackling maternal mortality. AIM:  To assess the level of husbands' participation in BPCR and associated factors. SETTING:  Wolaita Sodo town, Southern Ethiopia. METHODS:  A community based cross-sectional study was conducted among 608 husbands of pregnant women and nursing mothers...
April 11, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29780869/cross-sectional-and-longitudinal-atrophy-is-preferentially-associated-with-tau-rather-than-amyloid-%C3%AE-positron-emission-tomography-pathology
#4
Brian A Gordon, Austin McCullough, Shruti Mishra, Tyler M Blazey, Yi Su, John Christensen, Aylin Dincer, Kelley Jackson, Russ C Hornbeck, John C Morris, Beau M Ances, Tammie L S Benzinger
Introduction: Structural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology. Prior work has shown that both amyloid β (Aβ) and tau biomarkers are related to cortical thinning, but it is unclear what unique influences they have on the brain. Methods: Aβ pathology was measured with [18 F] AV-45 (florbetapir) positron emission tomography (PET) and tau was assessed with [18 F] AV-1451 (flortaucipir) PET in a population of 178 older adults, of which 123 had longitudinal magnetic resonance imaging assessments (average of 5...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29777645/-childbirth-is-not-a-sickness-a-woman-should-struggle-to-give-birth-exploring-continuing-popularity-of-home-births-in-western-kenya
#5
Violet Naanyu, Joyce Baliddawa, Beatrice Koech, Julie Karfakis, Nancy Nyagoha
More than 95% of Kenyan women receive antenatal care (ANC) and only 62% access skilled delivery. To explore women's opinion on delivery location, 20 focus group discussions were conducted at an urban and rural setting in western Kenya. Participants included health care workers, traditional birth attendants (TBAs), and women who attended at least four ANC visits and delivered. Six in-depth interviews were also conducted with a combination of women who gave birth in a facility and at home. Discussions were digitally recorded and transcribed for analysis...
March 2018: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29769047/uptake-of-skilled-attendance-along-the-continuum-of-care-in-rural-western-kenya-selected-analysis-from-global-health-initiative-survey-2012
#6
Winfred Mwangi, Onesmus Gachuno, Meghna Desai, David Obor, Vincent Were, Frank Odhiambo, Amek Nyaguara, Kayla F Laserson
BACKGROUND: Examining skilled attendance throughout pregnancy, delivery and immediate postnatal period is proxy indicator on the progress towards reduction of maternal and neonatal mortality in developing countries. METHODS: We conducted a cross-sectional baseline survey of households of mothers with at least 1 child under-5 years in 2012 within the KEMRI/CDC health and demographic surveillance system (HDSS) area in rural western Kenya. RESULTS: Out of 8260 mother-child pairs, data on antenatal care (ANC) in the most recent pregnancy was obtained for 89% (n = 8260); 97% (n = 7387) reported attendance...
May 16, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29767725/advancing-the-health-of-women-and-newborns-predictors-of-patient-satisfaction-among-women-attending-antenatal-and-maternity-care-in-rural-rwanda
#7
Christine Mutaganzwa, Leah Wibecan, Hari S Iyer, Evrard Nahimana, Anatole Manzi, Francois Biziyaremye, Merab Nyishime, Fulgence Nkikabahizi, Lisa R Hirschhorn, Hema Magge
Objective: Identify predictors of patient satisfaction with antenatal care (ANC) and maternity services in rural Rwanda. Design: Cross-sectional. Setting: Twenty-six health facilities in Southern Kayonza (SK) and Kirehe districts. Participants: Sample of women ≥ 16 years old receiving antenatal and delivery care between November and December 2013. Intervention: Survey of patient satisfaction with antenatal and delivery care to inform quality improvement (QI) initiatives aimed at reducing neonatal mortality...
May 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29758443/health-care-seeking-behaviour-during-pregnancy-delivery-and-the-postnatal-period-in-bangladesh-assessing-the-compliance-with-who-recommendations
#8
M Mazharul Islam, Mohammad Shahed Masud
BACKGROUND: The World Health Organization (WHO) recommends four antenatal care (ANC) visits, delivery in a health facility and three postnatal care (PNC) visits for women to optimize the maternal health outcomes. OBJECTIVES: To examine the level and determinants of maternal health care seeking behaviour during pregnancy, delivery and the postnatal period, and assess the compliance with the WHO recommended levels of care in Bangladesh. DESIGN/SETTING: The study is based on secondary analysis of the data obtained from the 2014 Bangladesh Demographic and Health Survey (BDHS)...
April 30, 2018: Midwifery
https://www.readbyqxmd.com/read/29755706/infectious-risks-and-complications-in-adult-leukemic-patients-receiving-blinatumomab
#9
Wonhee So, Shuchi Pandya, Rod Quilitz, Bijal Shah, John N Greene
Background: Blinatumomab is an anti-CD19 immunotherapy approved for relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) with significantly increased survival rate. While blinatumomab showed lower rates of infection, neutropenia and mucosal barrier injury versus chemotherapy, its infection risks are not well described. Methods: All patients who received blinatumomab for ≥ seven days at an academic cancer center from May 2015 to April 2017 were included...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29752056/utility-of-angle-correction-for-hemodynamic-measurements-with-doppler-echocardiography
#10
Martin I Sigurdsson, Eun J Eoh, Vinca W Chow, Nathan H Waldron, Jayne Cleve, Alina Nicoara, Madhav Swaminathan
OBJECTIVES: The routine application angle correction (AnC) in hemodynamic measurements with transesophageal echocardiography currently is not recommended but potentially could be beneficial. The authors hypothesized that AnC can be applied reliably and may change grading of aortic stenosis (AS). DESIGN: Retrospective analysis. SETTING: Single institution, university hospital. PARTICIPANTS: During phase I, use of AnC was assessed in 60 consecutive patients with intraoperative transesophageal echocardiography...
April 6, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29751797/the-effects-of-centering-pregnancy-on-maternal-and-fetal-outcomes-in-northern-nigeria-a-prospective-cohort-analysis
#11
George I Eluwa, Sylvia B Adebajo, Kwasi Torpey, Oladapo Shittu, Shittu Abdu-Aguye, Daniel Pearlman, Umma Bawa, Aira Olorukooba, Hadiza Khamofu, Robert Chiegli
BACKGROUND: Maternal and infant mortality remains high in Nigeria primarily due to low use of skilled birth attendants. Huge disparities exist between southern and northen Nigeria on use of skilled birth attendants with south significantly higher than the north. We assessed the effect of centering pregnancy group (CPG) antenatal care on the uptake of antenatal care (ANC), facility delivery and immunization rates for infants in Kano state. METHODS: Between December 2012 and May 2014, pregnant women with similar sociodemographics and obstetric history were enrolled into intervention (CPG) and control groups and followed up prospectively...
May 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29748750/clinical-and-laboratory-features-of-children-with-community-acquired-pneumonia-are-associated-with-distinct-radiographic-presentations
#12
Oana G Falup-Pecurariu, Javier Diez-Domingo, Susanna Esposito, Adam Finn, Fernanda Rodrigues, Vana Spoulou, George A Syrogiannopoulos, Vytautas Usonis, David Greenberg
Chest radiographs from children with community-acquired pneumonia (CAP) were categorized into three distinct presentations and each presentation was correlated to clinical and laboratory findings. Children < 59 months with CAP presenting to pediatric emergency rooms during two years were enrolled prospectively in eight centers across Europe. Clinical and laboratory data were documented and radiographs obtained from patients. Of the 1107 enrolled patients, radiographs were characterized as 74.9% alveolar CAP, 8...
May 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29748008/predicting-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer-enrolled-in-early-phase-immunotherapy-trials
#13
Hossein Maymani, Kenneth Hess, Roman Groisberg, David S Hong, Aung Naing, Sarina Piha-Paul, Filip Janku, Siqing Fu, Apostolia M Tsimberidou, Shubham Pant, Daniel Karp, Shuang Liu, Ming Sun, John Heymach, George Simon, Funda Meric-Bernstam, Vivek Subbiah
OBJECTIVES: Immunotherapy (IO) has altered the non-small cell lung cancer (NSCLC) therapeutic landscape. However, the majority of patients do not respond to immune-checkpoint blockade, and subsequently either receive further chemotherapy or are referred for clinical trials. Here we examined the outcomes and predictors of response to IO in early phase clinical trials. MATERIALS AND METHODS: We analyzed the records of 74 patients with metastatic NSCLC that were enrolled on phase 1 IO trials within MD Anderson Cancer Center from 1/2010 to 7/2017...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29746704/the-evolutionary-history-of-colour-polymorphism-in-ischnura-damselflies
#14
Rosa A Sánchez-Guillén, Adolfo Cordero-Rivera, Anais Rivas-Torres, Maren Wellenreuther, Seth Bybee, Bengt Hansson, María I Velasquez-Vélez, Emilio Realpe, Jesús R Chávez-Ríos, Fabricio Villalobos, Henri Dumont
A major challenge in evolutionary biology consists of understanding how genetic and phenotypic variation is created and maintained. In the present study, we investigated the origin(s) and evolutionary patterns of the female-limited colour polymorphism in ischnuran damselflies. These consist of the presence of one to three colour morphs: one androchrome morph with a colouration that is similar to the male, and two gynochrome morphs (infuscans and aurantiaca) with female-specific colouration. We (i) documented the colour and mating system of 44 of the 75 taxa within the genus Ischnura, (ii) reconstructed the evolutionary history of colour and mating system to identify the ancestral state, (iii) evaluated the stability of the colour morph status over time, and (iv) tested for a correlation between colour and mating system...
May 10, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29743103/husband-s-involvement-with-mother-s-awareness-and-knowledge-of-newborn-danger-signs-in-facility-based-childbirth-settings-a-cross-sectional-study-from-rural-bangladesh
#15
Sojib Bin Zaman, Rajat Das Gupta, Gulam Muhammed Al Kibria, Naznin Hossain, Md Mofijul Islam Bulbul, Dewan Md Emdadul Hoque
OBJECTIVE: The aim of this study was to examine the association between husband involvement and maternal awareness and knowledge of newborn danger signs. This cross-sectional study was conducted in three rural hospitals of Bangladesh among the recently delivered women (RDW). RESULTS: RDW were interviewed to determine their knowledge and understanding of seven key neonatal danger signs. About 51.4% of the respondents were able to identify at least one danger sign...
May 9, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29743039/male-partner-attendance-at-antenatal-care-and-adherence-to-antenatal-care-guidelines-secondary-analysis-of-2011-ethiopian-demographic-and-health-survey-data
#16
Faye Forbes, Karen Wynter, Catherine Wade, Berihun M Zeleke, Jane Fisher
BACKGROUND: Complications during pregnancy, childbirth and the postpartum period present a significant and complex public health problem in low income countries such as Ethiopia. One strategy endorsed by the World Health Organisation (WHO) to improve maternal and child health outcomes is to encourage male partner involvement in pregnancy care. This research aimed to explore the relationships between 1) male attendance at antenatal care and 2) socio-economic and women's empowerment factors and adherence to focused antenatal care guidelines among women receiving care in Ethiopia...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29742132/hiv-drug-resistance-patterns-in-pregnant-women-using-next-generation-sequence-in-mozambique
#17
María Rupérez, Marc Noguera-Julian, Raquel González, Sonia Maculuve, Rocío Bellido, Anifa Vala, Cristina Rodríguez, Esperança Sevene, Roger Paredes, Clara Menéndez
BACKGROUND: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (pMTCT) and antenatal care. OBJECTIVES: To describe the frequency and characteristics of HIV drug resistance mutations (HIVDRM) in pregnant women with virological failure at delivery, despite pMTCT or antiretroviral therapy (ART)...
2018: PloS One
https://www.readbyqxmd.com/read/29740487/label-free-quantitative-proteomic-analysis-identifies-ctnnb1-as-a-direct-target-of-foxp3-in-gastric-cancer-cells
#18
Du-Yi Pan, Xiao-Qing Zeng, Gui-Fen Ma, Jing Gao, Na Li, Qing Miao, Jing-Jing Lian, Hu Zhou, Li-Li Xu, Shi-Yao Chen
Forkhead box protein 3 (FOXP3) is expressed in numerous types of tumor cell and is associated with tumor progression and prognosis. A previous study reported that FOXP3 inhibited cellular proliferation and induced apoptosis of gastric cancer (GC) cells by activating the apoptosis signaling pathway. In the present study, label-free quantitative proteomic analysis and chromatin immunoprecipitation-polymerase chain reaction (ChIP-PCR) was performed to investigate the mechanism by which the anticancer role of FOXP3 was mediated and the proteins that with which it may interact...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29732352/pegfilgrastim-for-primary-prophylaxis-of-febrile-neutropenia-in-breast-cancer-patients-undergoing-tac-chemotherapy
#19
Jihyoun Lee, Jong Eun Lee, Zisun Kim, Sun Wook Han, Sung Mo Hur, Sung Yong Kim, Min Hyuk Lee, Cheol Wan Lim
Purpose: Primary prophylaxis with granulocyte colony-stimulating factor can effectively prevent febrile neutropenia (FN) during breast cancer treatment. The aims of this study were to evaluate the incidence of FN and the ANC profile in patients undergoing chemotherapy and pegfilgrastim primary prophylaxis. Methods: Patients receiving 6 cycles of adjuvant docetaxel, doxorubicin, and cyclophosphamide (TAC) chemotherapy were included in this study. Pegfilgrastim was administered with analgesics 24 hours after treatment...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29728136/diagnostic-performance-of-direct-wet-mount-microscopy-in-detecting-intestinal-helminths-among-pregnant-women-attending-ante-natal-care-anc-in-east-wollega-oromia-ethiopia
#20
Hylemariam Mihiretie Mengist, Gebreselassie Demeke, Olifan Zewdie, Adugna Belew
OBJECTIVE: The aim of this study was to evaluate the diagnostic performance of direct wet mount microscopy compared to formalin ether concentration (FEC) technique in detecting intestinal helminths in pregnant women. RESULTS: The total prevalence of intestinal helminths was 18.8% (70/372) by direct wet mount microscopy and 24.7% (92/372) by FEC technique (P < 0.001). The sensitivity, negative predictive value (NPV) and test efficiency (TE) of direct wet mount microscopy in diagnosing intestinal helminths was 76, 92...
May 4, 2018: BMC Research Notes
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