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https://www.readbyqxmd.com/read/28641645/-subtype-and-functional-biomarker-changes-of-nk-cells-in-peripheral-blood-of-patients-with-myelodysplastic-syndrome
#1
Shu-Juan Xu, Zong-Hong Shao, Rong Fu, Hua-Quan Wang, Hui Liu, Chun-Yan Liu, Wei Zhang
OBJECTIVE: To analyze the subtype and functional biomarker expression changes of natural kill cells(NK) in peripheral blood of patients with myelodysplastic syndrome(MDS) and normal people, so as to evaluate the relationships between these changes and hematopoietic functions and to explore the role of NK cells in the pathogenesis of MDS. METHODS: The quantity of NK cells and the expression of biomarkers(NKp30,NKp46,NKG2A) on NK cells were detected by flow cytometry in 35 MDS patients from 2015 to 2016 in our hospital and 34 normal controls...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28640540/the-effects-of-advanced-age-and-serum-%C3%AE-1-acid-glycoprotein-on-docetaxel-unbound-exposure-and-dose-limiting-toxicity-in-cancer-patients
#2
Hirotsugu Kenmotsu, Chiyo K Imamura, Akira Ono, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Toshiaki Takahashi, Yusuke Tanigawara
AIM: α1 -Acid glycoprotein (AAG), which is a major binding protein of docetaxel, is considered to be a determinant for docetaxel pharmacokinetics. However, there are no reports about the impact of serum AAG on pharmacokinetics and pharmacodynamics in elderly patients treated with docetaxel. The aim of this prospective study was to elucidate the effects of advanced age and serum AAG on docetaxel unbound exposure and neutropenia, dose-limiting toxicity, in cancer patients. METHODS: Docetaxel was administered at 60 mg/m(2) to 51 patients with non-small cell lung cancer, 17 of whom were ≥ 75 years of age...
June 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28638835/quality-improvement-interventions-for-nutritional-assessment-among-pregnant-mothers-in-northeastern-uganda
#3
Jonathan Izudi, Calvin Epidu, Andrew Katawera, Adeodata Kekitiinwa
INTRODUCTION: Assessment of pregnant mothers for nutritional status is a neglected intervention. In Kaabong Hospital, nutritional status of pregnant mothers was not assessed during antenatal care (ANC) visits. A quality improvement (QI) project was initiated to increase nutritional assessment using midupper arm circumference (MUAC) among pregnant mothers during ANC visits from 0 to 90% between April and September 2015. METHOD: Baylor-Uganda formed ANC Work Improvement Team (WIT) that reviewed ANC register, identified gaps in quality of care, analyzed root causes using cause-effect diagram, developed solutions, and tested and implemented the solution using Plan-Do-Study-Act cycles...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28637500/association-of-antenatal-care-and-place-of-delivery-with-newborn-care-practices-evidence-from-a-cross-sectional-survey-in-rural-uttar-pradesh-india
#4
Niveditha Devasenapathy, Sutapa B Neogi, Srinivasan Soundararajan, Danish Ahmad, Avishek Hazra, Jaleel Ahmad, Neelakshi Mann, Dileep Mavalankar
BACKGROUND: Appropriate immediate newborn care is vital for neonatal survival. Antenatal period is a crucial time to impart knowledge and awareness to mothers regarding newborn care, either during facility visits or during home visits by community health workers (CHWs) especially in the rural context. In this paper, we report newborn care practices in rural Uttar Pradesh (UP) and have explored association between newborn care practices with antenatal care, contact with community health workers during pregnancy and place of childbirth...
June 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28635283/piezoresistive-effect-in-the-fe-htrz-2-trz-bf4-spin-crossover-complex
#5
Andrei Diaconu, Simona-Lacramioara Lupu, Ionela Rusu, Ioan-Marian Risca, Lionel Salmon, Gabor Molnár, Azzedine Bousseksou, Philippe Demont, Aurelian Rotaru
We report on the effect of hydrostatic pressure on the electrical conductivity and dielectric permittivity of the [Fe(Htrz)2(trz)](BF4) (Htrz = 1H-1,2,4, triazole) spin crossover complex. Variable temperature and pressure broadband imped-ance spectrometry revealed a piezo-resistive effect of more than one order of magnitude for pressures as low as 500 bar, associated with a large pressure-induced hysteresis of 1700 bar. The origin of the piezo-resistive effect has been attributed to the pressure induced spin-state switching in the complex and the associated P,T phase diagram was determined...
June 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28621201/effectiveness-of-antenatal-care-services-in-reducing-neonatal-mortality-in-kenya-analysis-of-national-survey-data
#6
Malachi Arunda, Anders Emmelin, Benedict Oppong Asamoah
BACKGROUND: Although global neonatal mortality declined by about 40 percent from 1990 to 2013, it still accounted for about 2.6 million deaths globally and constituted 42 percent of global under-five deaths. Most of these deaths occur in developing countries. Antenatal care (ANC) is a globally recommended strategy used to prevent neonatal deaths. In Kenya, over 90 percent of pregnant women attend at least one ANC visit during pregnancy. However, Kenya is currently among the 10 countries that contribute the most neonatal deaths globally...
2017: Global Health Action
https://www.readbyqxmd.com/read/28604825/burden-and-impact-of-plasmodium-vivax-in-pregnancy-a-multi-centre-prospective-observational-study
#7
Azucena Bardají, Flor Ernestina Martínez-Espinosa, Myriam Arévalo-Herrera, Norma Padilla, Swati Kochar, Maria Ome-Kaius, Camila Bôtto-Menezes, María Eugenia Castellanos, Dhanpat Kumar Kochar, Sanjay Kumar Kochar, Inoni Betuela, Ivo Mueller, Stephen Rogerson, Chetan Chitnis, Dhiraj Hans, Michela Menegon, Carlo Severini, Hernando Del Portillo, Carlota Dobaño, Alfredo Mayor, Jaume Ordi, Mireia Piqueras, Sergi Sanz, Mats Wahlgren, Laurence Slutsker, Meghna Desai, Clara Menéndez
BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28601903/can-complications-in-febrile-neutropenia-be-predicted-report-from-a-developing-country
#8
Sapna Oberoi, Anirban Das, Amita Trehan, Pallab Ray, Deepak Bansal
PURPOSE: Febrile neutropenia (FN) is an important cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). We aimed to look at complications in febrile neutropenia and to derive a risk model for developing complications from the variables predicting complications. METHODS: Children on treatment for ALL, presenting with FN, were prospectively enrolled over a period of 1 year. Their clinical presentation, course during hospital stay, and outcomes were recorded...
June 11, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28598791/croi-2017-neurologic-complications-of-hiv-infection
#9
Serena S Spudich, Beau M Ances
The brain is a major target for HIV infection and is a potential viral reservoir even in virologically well-controlled HIV-infected individuals. Data presented at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI) suggested that during early HIV infection, CD4+ T cells in the meninges and choroid plexus serve as an important early site of HIV infection in the central nervous system (CNS), with brain macrophages and microglial cells becoming an important source of viral replication with advancing disease...
May 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28597691/safety-and-efficacy-of-pegfilgrastim-when-given-less-than-14-days-before-the-next-chemotherapy-cycle-retrospective-review-of-every-14-day-chemotherapy-regimen-containing-5-fu-continuous-infusion
#10
Kofi N Donkor, Julie H Selim, Ariani Waworuntu, Kelsey Lewis
BACKGROUND: Pegfilgrastim should not be given <14 days from the next chemotherapy because of concerns for cytopenias. Some clinicians are prescribing pegfilgrastim to be given <14 days in patients receiving 5-fluorouracil continuous infusion (5-FUCI) regimens. OBJECTIVE: To determine the effectiveness and safety of pegfilgrastim administered <14 days from the next chemotherapy in patients receiving 5-FUCI administered >46 hours. METHODS: Single-institution retrospective cohort study of patients who received 5-FUCI administered >46 hours from June 2013 to December 2015...
June 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28597050/is-there-a-role-for-sentinel-node-biopsy-in-the-pre-operative-ultrasound-positive-axilla
#11
EDITORIAL
M Ahmed, F Jozsa, M Douek
Axillary management in breast cancer is becoming increasingly conservative. This approach is based on the identification of low axillary burden on sentinel node biopsy (SNB). The modern practice of routine pre-operative axillary ultrasound has meant that patients are 'fast tracked' to axillary node clearance (ANC) in the presence of a histologically confirmed positive axilla. This practice reduces the number of patients undergoing SNB compared to the original trials, which evaluated the role of SNB, and those assessing safety of omission of ANC in low axillary burden...
June 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28592126/autologous-hematopoietic-stem-cell-transplantation-for-acute-myeloid-leukemia-single-center-experience
#12
I Simancikova, E Bojtarova, M Hrubisko, F Farkas, D Horvathova, L Sopko, A Batorova, M Mistrik
We aimed to determine the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on acute myeloid leukemia (AML) patients as a valid alternative therapeutic option for patients without HLA-compatible donor. This retrospective single center study included 79 patients with AML older than 18 years. In this report, we describe the patient characteristics, engraftment, toxicity of treatment, complications, overall survival, and relapse incidence of 79 patients treated chemotherapy and followed by auto-HSCT...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28591972/-one-carrier-of-robinsoniella-peoriensis-in-china
#13
Jing-Yu Yang, Xiao-Xia Zhang, Ru-Jia Yu, Ping Feng, Zhi-Yong Zong
OBJECTIVES: To study morphological feature, biochemical characteristic and antibiotic resistance of Robinsoniella peoriensis (R.peoriensis) strain. METHODS: The clinical R.peoriensis strain was isolated from ananus swab samples being screened in ICU. Biochemical characteristic of the strain was completed by fully automatic microbial identification and drug susceptibility analysis system (BioMérieux, Marcy-l'éE toile, France) with the ANC Vitek2. Antibiotic susceptibility in vitro was performed using agar dilution...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28590372/changes-in-neutrophil-count-after-antipsychotic-prescription-among-a-retrospective-cohort-of-patients-with-benign-neutropenia
#14
Paul Campion, Gabriel Campion, Deepti Anbarasan
BACKGROUND: There is a paucity of literature regarding the effect of antipsychotics on absolute neutrophil count (ANC) of patients with benign neutropenia (BN). We evaluated the change in ANC after atypical antipsychotic prescription (excluding clozapine) in a retrospective cohort of 22 patients with BN. METHODS/PROCEDURES: Records of all patients with BN who were prescribed antipsychotics and who had ANC measured before and during antipsychotic treatment were obtained from Bronx VA Medical Center between 2005 and 2015 (inclusive)...
June 5, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28588940/wealth-education-and-urban-rural-inequality-and-maternal-healthcare-service-usage-in-malawi
#15
Sanni Yaya, Ghose Bishwajit, Vaibhav Shah
BACKGROUND: Malawi is among the 5 sub-Saharan African countries presenting with very high maternal mortality rates, which remain a challenge. This study aims to examine the impact of wealth inequality and area of residence (urban vs rural) and education on selected indicators of maternal healthcare services (MHS) usage in Malawi. METHODS: This study was based on data from the 5th round of Multiple Indicator Cluster Surveys (MICS) conducted in 2013-2014 in Malawi...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28579709/timing-of-first-antenatal-care-visit-and-its-associated-factors-among-pregnant-women-attending-public-health-facilities-in-addis-ababa-ethiopia
#16
Hanna Gulema, Yemane Berhane
BACKGROUND: Early initiation of antenatal care visits is an essential component of services to improving maternal and new born health. The Ethiopian Demographic and Health Survey conducted in 2011 indicated that only 11% of pregnant women start antenatal care in the first trimester. However, detailed study to identify factors associated with late initiation of care has not been conducted in Addis Ababa where access to health services is almost universal. The aim of this study was to assess the level of late first antenatal care visit and the associated factors...
March 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28578634/determinants-of-attending-antenatal-care-at-least-four-times-in-rural-ghana-analysis-of-a-cross-sectional-survey
#17
Evelyn Sakeah, Sumiyo Okawa, Abraham Rexford Oduro, Akira Shibanuma, Evelyn Ansah, Kimiyo Kikuchi, Margaret Gyapong, Seth Owusu-Agyei, John Williams, Cornelius Debpuur, Francis Yeji, Vida Ami Kukula, Yeetey Enuameh, Gloria Quansah Asare, Enoch Oti Agyekum, Sheila Addai, Doris Sarpong, Kwame Adjei, Charlotte Tawiah, Junko Yasuoka, Keiko Nanishi, Masamine Jimba, Abraham Hodgson, The Ghana Embrace Team
BACKGROUND: Improving maternal health is a global challenge. In Ghana, maternal morbidity and mortality rates remain high, particularly in rural areas. Antenatal care (ANC) attendance is known to improve maternal health. However, few studies have updated current knowledge regarding determinants of ANC attendance. OBJECTIVE: This study examined factors associated with ANC attendance in predominantly rural Ghana. METHODS: We conducted a cross-sectional study at three sites (i...
2017: Global Health Action
https://www.readbyqxmd.com/read/28574979/antenatal-corticosteroids-and-cardio-metabolic-outcomes-in-adolescents-born-with-very-low-birth-weight
#18
Lisa K Washburn, Patricia A Nixon, Beverly M Snively, Gregory B Russell, Hossam A Shaltout, Andrew M South, T Michael O'Shea
BACKGROUND: Exposure to antenatal corticosteroids (ANCS) is associated with adverse cardio-metabolic outcomes in animal models; however long-term outcomes in clinical studies are not well characterized. We hypothesized that exposure to ANCS would be associated with markers of increased cardio-metabolic risk in adolescents born with very low birth weight (VLBW). METHODS: In an observational cohort of 186 VLBW 14-year-old adolescents we measured resting blood pressure (BP), BP response to cold, ambulatory BP, and anthropometrics; performed dual-energy X-ray absorptiometry; and analyzed blood samples for uric acid, cholesterol, glycated hemoglobin, and high-sensitivity C-reactive protein...
June 2, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28566088/factors-associated-with-utilization-of-skilled-service-delivery-among-women-in-rural-northern-ghana-a-cross-sectional-study
#19
William Gudu, Bright Addo
BACKGROUND: Ghana's current Maternal Mortality Ratio (MMR) of 319 per 100,000 live births makes achievement of the Sustainable Development Goal of 70 maternal deaths per 100,000 live births or less by 2030 appear to be illusory. Skilled assistance during childbirth is a critical strategy to reducing maternal mortality, yet the proportion of deliveries taking place within health facilities where such assistance is provided is very low in Ghana, with huge disparity between urban and rural women...
May 31, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28558812/introducing-onsite-antenatal-syphilis-screening-in-burkina-faso-implementation-and-evaluation-of-a-feasibility-intervention-tailored-to-a-local-context
#20
Fadima Yaya Bocoum, Grissoum Tarnagda, Fabrice Bationo, Justin R Savadogo, Sarata Nacro, Séni Kouanda, Christina Zarowsky
BACKGROUND: Although the advantages of introducing point of care testing for syphilis in antenatal care (ANC) are well documented, there is little evidence on how to address structural issues within health systems. A better understanding of how these interventions work in a range of settings and contexts is needed in order to overcome bottlenecks at health system level. To better understand the relationships between implementation and context we developed and implemented an intervention focused on integrating a rapid screening test for syphilis in ANC services in rural primary health care facilities in Burkina Faso...
May 30, 2017: BMC Health Services Research
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