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Images in Clinical Medicine

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https://www.readbyqxmd.com/read/29044721/body-diffusion-weighted-imaging-using-magnetization-prepared-single-shot-fast-spin-echo-and-extended-parallel-imaging-signal-averaging
#1
Eric K Gibbons, Shreyas S Vasanawala, John M Pauly, Adam B Kerr
PURPOSE: This work demonstrates a magnetization prepared diffusion-weighted single-shot fast spin echo (SS-FSE) pulse sequence for the application of body imaging to improve robustness to geometric distortion. This work also proposes a scan averaging technique that is superior to magnitude averaging and is not subject to artifacts due to object phase. THEORY AND METHODS: This single-shot sequence is robust against violation of the Carr-Purcell-Meiboom-Gill (CPMG) condition...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29040639/the-medical-science-dmz-a-network-design-pattern-for-data-intensive-medical-science
#2
Sean Peisert, Eli Dart, William Barnett, Edward Balas, James Cuff, Robert L Grossman, Ari Berman, Anurag Shankar, Brian Tierney
Objective: We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods: High-end networking, packet-filter firewalls, network intrusion-detection systems. Results: We describe a "Medical Science DMZ" concept as an option for secure, high-volume transport of large, sensitive datasets between research institutions over national research networks, and give 3 detailed descriptions of implemented Medical Science DMZs...
October 6, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29038380/integrating-nanomedicine-and-imaging
#3
REVIEW
Carlos Pérez-Medina, Sjoerd Hak, Thomas Reiner, Zahi A Fayad, Matthias Nahrendorf, Willem J M Mulder
Biomedical engineering and its associated disciplines play a pivotal role in improving our understanding and management of disease. Motivated by past accomplishments, such as the clinical implementation of coronary stents, pacemakers or recent developments in antibody therapies, disease management now enters a new era in which precision imaging and nanotechnology-enabled therapeutics are maturing to clinical translation. Preclinical molecular imaging increasingly focuses on specific components of the immune system that drive disease progression and complications, allowing the in vivo study of potential therapeutic targets...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29037377/thermographic-imaging-in-sports-and-exercise-medicine-a-delphi-study-and-consensus-statement-on-the-measurement-of-human-skin-temperature
#4
REVIEW
Danilo Gomes Moreira, Joseph T Costello, Ciro J Brito, Jakub G Adamczyk, Kurt Ammer, Aaron J E Bach, Carlos M A Costa, Clare Eglin, Alex A Fernandes, Ismael Fernández-Cuevas, José J A Ferreira, Damiano Formenti, Damien Fournet, George Havenith, Kevin Howell, Anna Jung, Glen P Kenny, Eleazar S Kolosovas-Machuca, Matthew J Maley, Arcangelo Merla, David D Pascoe, Jose I Priego Quesada, Robert G Schwartz, Adérito R D Seixas, James Selfe, Boris G Vainer, Manuel Sillero-Quintana
The importance of using infrared thermography (IRT) to assess skin temperature (tsk) is increasing in clinical settings. Recently, its use has been increasing in sports and exercise medicine; however, no consensus guideline exists to address the methods for collecting data in such situations. The aim of this study was to develop a checklist for the collection of tsk using IRT in sports and exercise medicine. We carried out a Delphi study to set a checklist based on consensus agreement from leading experts in the field...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037014/deep-into-the-brain-artificial-intelligence-in-stroke-imaging
#5
REVIEW
Eun-Jae Lee, Yong-Hwan Kim, Namkug Kim, Dong-Wha Kang
Artificial intelligence (AI), a computer system aiming to mimic human intelligence, is gaining increasing interest and is being incorporated into many fields, including medicine. Stroke medicine is one such area of application of AI, for improving the accuracy of diagnosis and the quality of patient care. For stroke management, adequate analysis of stroke imaging is crucial. Recently, AI techniques have been applied to decipher the data from stroke imaging and have demonstrated some promising results. In the very near future, such AI techniques may play a pivotal role in determining the therapeutic methods and predicting the prognosis for stroke patients in an individualized manner...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036455/jlcs-medical-practice-guidelines-for-thymic-tumors-summary-of-recommendations
#6
Kohei Yokoi, Kazuya Kondo, Kiminori Fujimoto, Masaki Hara, Yoshihisa Kadota, Koji Kawaguchi, Hideo Kunitoh, Yoshihiro Matsuno, Jun Nakajima, Makoto Nishio, Kazuhiko Ogawa, Mitsugu Omasa
The Guideline Committee of the Japan Lung Cancer Society (JLCS) for Thymic Tumors published the Medical Practice Guideline for Thymic Tumors in Japanese as Chapter 3 of the Medical Practice Guidelines for Lung Cancers according to evidence-based medicine in December 2016. This medical practice guideline is the first for thymic epithelial tumors in Japan, and comprises a set of recommendations covering clinical diagnosis, treatment and pathological diagnosis. Thymic epithelial tumors include thymoma, thymic carcinoma and thymic neuroendocrine tumor...
September 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29030882/accelerated-multicontrast-volumetric-imaging-with-isotropic-resolution-for-improved-peri-infarct-characterization-using-parallel-imaging-low-rank-and-spatially-varying-edge-preserving-sparse-modeling
#7
Li Zhang, Peng Lai, Mihaela Pop, Graham A Wright
PURPOSE: To achieve consistent effectiveness in reconstruction of fine image features for cases of varying contrast-to-noise ratio (CNR) to facilitate translating accelerated multicontrast volumetric imaging with isotropic resolution toward clinical utility in peri-infarct characterization. THEORY AND METHODS: A low-rank and spatially varying edge-preserving constrained compressed sensing parallel imaging reconstruction method (CP-LASER) is developed to effectively preserve contrast of small-scale structures for highly accelerated multicontrast volumetric imaging in CNR-limited scenarios...
October 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29030880/direct-saturation-corrected-chemical-exchange-saturation-transfer-mri-of-glioma-simplified-decoupling-of-amide-proton-transfer-and-nuclear-overhauser-effect-contrasts
#8
Iris Yuwen Zhou, Enfeng Wang, Jerry S Cheung, Dongshuang Lu, Yang Ji, Xiaoan Zhang, Giulia Fulci, Phillip Zhe Sun
PURPOSE: Chemical exchange saturation transfer (CEST) MRI has shown promise in tissue characterization in diseases like stroke and tumor. However, in vivo CEST imaging such as amide proton transfer (APT) MRI is challenging because of concomitant factors such as direct water saturation, macromolecular magnetization transfer, and nuclear overhauser effect (NOE), which lead to a complex contrast in the commonly used asymmetry analysis (MTRasym). Here, we propose a direct saturation-corrected CEST (DISC-CEST) analysis for simplified decoupling and quantification of in vivo CEST effects...
October 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#9
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025377/18f-fdg-pet-ct-in-breast-cancer-evidence-based-recommendations-in-initial-staging
#10
REVIEW
Ana Paula Caresia Aroztegui, Ana María García Vicente, Soledad Alvarez Ruiz, Roberto Carlos Delgado Bolton, Javier Orcajo Rincon, Jose Ramon Garcia Garzon, Maria de Arcocha Torres, Maria Jose Garcia-Velloso
Current guidelines do not systematically recommend 18F-FDG PET/CT for breast cancer staging; and the recommendations and level of evidence supporting its use in different groups of patients vary among guidelines. This review summarizes the evidence about the role of 18F-FDG PET/CT in breast cancer staging and the therapeutic and prognostic impact accumulated in the last decade. Other related aspects, such as the association of metabolic information with biology and prognosis are considered and evidence-based recommendations for the use of 18F-FDG PET/CT in breast cancer staging are offered...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29024838/organ-on-chip-models-of-cancer-metastasis-for-future-personalized-medicine-from-chip-to-the-patient
#11
REVIEW
D Caballero, S Kaushik, V M Correlo, J M Oliveira, R L Reis, S C Kundu
Most cancer patients do not die from the primary tumor but from its metastasis. Current in vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of various clinical treatments on patients. This is seen as a serious limitation and efforts are underway to develop a new generation of highly predictive cancer models with advanced capabilities. In this regard, organ-on-chip models of cancer metastasis emerge as powerful predictors of disease progression. They offer physiological-like conditions where the (hypothesized) mechanistic determinants of the disease can be assessed with ease...
October 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/29023975/motion-robust-high-resolution-3d-free-breathing-pulmonary-mri-using-dynamic-3d-image-self-navigator
#12
Wenwen Jiang, Frank Ong, Kevin M Johnson, Scott K Nagle, Thomas A Hope, Michael Lustig, Peder E Z Larson
PURPOSE: To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. METHODS: Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states...
October 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29023277/diagnosis-and-treatment-of-slipping-rib-syndrome
#13
Cassidy M Foley, Dai Sugimoto, David P Mooney, William P Meehan, Andrea Stracciolini
OBJECTIVE: (1) To investigate the clinical presentation, diagnosis, and treatment of slipping rib syndrome in athletes; (2) to investigate the hooking maneuver for diagnosis of slipping rib syndrome. DESIGN: Retrospective chart review of 362 athletes with rib pain. SETTING: Pediatric-based sports medicine clinic between January 1, 1999, and March 1, 2014. PATIENTS: Costochondritis, Tietze, fractures, rib tip syndrome, and unclear diagnoses were excluded...
October 6, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29021839/diffusion-tensor-imaging-for-multilevel-assessment-of-the-visual-pathway-possibilities-for-personalized-outcome-prediction-in-autoimmune-disorders-of-the-central-nervous-system
#14
REVIEW
Joseph Kuchling, Alexander U Brandt, Friedemann Paul, Michael Scheel
The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29018631/multi-parameter-ensemble-learning-for-automated-vertebral-body-segmentation-in-heterogeneously-acquired-clinical-mr-images
#15
Bilwaj Gaonkar, Yihao Xia, Diane S Villaroman, Allison Ko, Mark Attiah, Joel S Beckett, Luke Macyszyn
The development of quantitative imaging biomarkers in medicine requires automatic delineation of relevant anatomical structures using available imaging data. However, this task is complicated in clinical medicine due to the variation in scanning parameters and protocols, even within a single medical center. Existing literature on automatic image segmentation using MR data is based on the analysis of highly homogenous images obtained using a fixed set of pulse sequence parameters (TR/TE). Unfortunately, algorithms that operate on fixed scanning parameters do not avail themselves to real-world daily clinical use due to the existing variation in scanning parameters and protocols...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29017354/persistent-sirs-and-acute-fluid-collections-are-associated-with-increased-ct-scanning-in-acute-interstitial-pancreatitis
#16
Ayesha Kamal, Mahya Faghih, Robert A Moran, Elham Afghani, Amitasha Sinha, Nasim Parsa, Martin A Makary, Atif Zaheer, Elliot K Fishman, Mouen A Khashab, Anthony N Kalloo, Vikesh K Singh
BACKGROUND: The use of computed tomography (CT) in acute pancreatitis (AP) continues to increase in parallel with the increasing use of diagnostic imaging in clinical medicine. AIM: To determine the factors associated with obtaining >1 CT scan in acute interstitial pancreatitis (AIP). METHODS: Demographic and clinical data of all adult patients admitted between 1/2010 and 1/2015 with AP (AP) were evaluated. Only patients with a CT severity index (CTSI) ≤ 3 on a CT obtained within 48 h of presentation were included...
October 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28994664/compton-camera-study-for-high-efficiency-spect-and-benchmark-with-anger-system
#17
Mattia Fontana, Denis Dauvergne, Jean Michel Letang, Jean-Luc Ley, Etienne Testa
Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection eciency and energy acceptance are limited and xed by the system's geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years...
October 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#18
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28990632/the-use-of-rgd-engineered-exosomes-for-enhanced-targeting-ability-and-synergistic-therapy-toward-angiogenesis
#19
Jie Wang, Wei Li, Zhichao Lu, Leicheng Zhang, Yu Hu, Qiubai Li, Wei Du, Xiaojun Feng, Haibo Jia, Bi-Feng Liu
Promoted therapeutic angiogenesis is a major objective in the area of regenerative medicine, and sufficient vascularization of artificial tissues or organs is one of the main difficulties for the realization of tissue engineering methods. The identification of new kinds of pro-angiogenic materials will greatly profit developments in regenerative medicine. The use of exosomes for this intention is a considerably new idea developed in recent years. However, several limitations need to be addressed before their use as clinical therapeutics, including the lack of efficient exosome enrichment and methods to endow exosomes with targeting ability...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28989174/new-treatment-paradigms-for-adpkd-moving-towards-precision-medicine
#20
REVIEW
Matthew B Lanktree, Arlene B Chapman
The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations. Precision medicine is proposed to improve patient outcomes by tailoring therapy to the specific genetic background, pathophysiology, disease burden, prognosis and status of each individual...
October 9, 2017: Nature Reviews. Nephrology
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