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https://www.readbyqxmd.com/read/29167275/residual-convolutional-neural-network-for-determination-of-idh-status-in-low-and-high-grade-gliomas-from-mr-imaging
#1
Ken Chang, Harrison X Bai, Hao Zhou, Chang Su, Wenya Linda Bi, Ena Agbodza, Vasileios K Kavouridis, Joeky T Senders, Alessandro Boaro, Andrew L Beers, Biqi Zhang, Alexandra Capellini, Weihua Liao, Qin Shen, Xuejun Li, Bo Xiao, Jane Cryan, Shakti Ramkissoon, Lori Ramkissoon, Keith L Ligon, Patrick Y Wen, Ranjit S Bindra, John H Woo, Omar Arnaout, Elizabeth Gerstner, Paul J Zhang, Bruce Rosen, Li Yang, Raymond Y Huang, Jayashree Kalpathy-Cramer
PURPOSE: Isocitrate dehydrogenase (<IDH) mutations in glioma patients confer longer survival and may guide treatment decision-making. We aimed to predict the IDH status of gliomas from MR imaging by applying a residual convolutional neural network to pre-operative radiographic data. EXPERIMENTAL DESIGN: Preoperative imaging was acquired for 201 patients from the Hospital of University of Pennsylvania (HUP), 157 patients from Brigham and Women's Hospital (BWH), and 138 patients from The Cancer Imaging Archive (TCIA) and divided into training, validation, and testing sets...
November 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28904251/effects-of-the-deletion-of-hup-genes-encoding-the-uptake-hydrogenase-on-the-activity-of-hydrogen-production-in-the-purple-photosynthetic-bacterium-rubrivivax-gelatinosus-il144
#2
Takeshi Sato, Kazuhito Inoue, Hidehiro Sakurai, Kenji V P Nagashima
The efficiency of hydrogen gas production by nitrogenase in bacteria has been improved by the inhibition of antagonistic activity by the uptake hydrogenase. In this study, a mutant lacking the gene coding for the uptake hydrogenase was generated from the photosynthetic beta-proteobacterium Rubrivivax gelatinosus IL144 to explore new ways of hydrogen gas production driven by light energy. The mutant cells produced 25-30% higher amounts of molecular hydrogen than the wild-type cells under nitrogen-deficient conditions under light...
September 12, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28887844/house-dust-mite-allergens-der-f-and-der-p-induce-il-31-production-by-blood-derived-t-cells-from-atopic-dermatitis-patients
#3
Krisztina Szegedi, Amanda van Lier, Pieter C Res, Saskia Chielie, Jan D Bos, Sanja Kezic, Maritza A Middelkamp-Hup, Rosalie M Luiten
No abstract text is available yet for this article.
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28846552/qualitative-and-quantitative-evaluation-of-structural-myocardial-alterations-by-grating-based-phase-contrast-computed-tomography
#4
Susan Notohamiprodjo, Nicole Webber, Lorenz Birnbacher, Marian Willner, Manuel Viermetz, Julia Herzen, Mathias Marschner, Doris Mayr, Harald Bartsch, Tobias Saam, Sigrid Auweter, Franz Pfeiffer, Maximilian F Reiser, Holger Hetterich
OBJECTIVES: Grating-based phase-contrast computed tomography (gb-PCCT) relies on x-ray refraction instead of absorption to generate high-contrast images in biological soft tissue. The aim of this study was to evaluate the potential of gb-PCCT for the depiction of structural changes in heart disease. MATERIALS AND METHODS: Four human heart specimens from patients with hypertensive disease, ischemic disease, dilated heart disease, and cardiac lipomatosis were examined...
August 25, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28827197/head-and-thorax-elevation-during-active-compression-decompression-cardiopulmonary-resuscitation-with-an-impedance-threshold-device-improves-cerebral-perfusion-in-a-swine-model-of-prolonged-cardiac-arrest
#5
Johanna C Moore, Nicolas Segal, Michael C Lick, Kenneth W Dodd, Bayert J Salverda, Mason B Hinke, Aaron E Robinson, Guillaume Debaty, Keith G Lurie
AIM OF THE STUDY: As most cardiopulmonary resuscitation (CPR) efforts last longer than 15min, the aim of this study was to compare brain blood flow between the Head Up (HUP) and supine (SUP) body positions during a prolonged CPR effort of 15min, using active compression-decompression (ACD) CPR and impedance threshold device (ITD) in a swine model of cardiac arrest. METHODS: Ventricular fibrillation (VF) was induced in anesthetized pigs. After 8min of untreated VF followed by 2min of ACD-CPR+ITD in the SUP position, pigs were randomized to 18min of continuous ACD-CPR+ITD in either a 30° HUP or SUP position...
August 5, 2017: Resuscitation
https://www.readbyqxmd.com/read/28739782/coadministration-of-allopurinol-to-increase-antimycobacterial-efficacy-of-pyrazinamide-as-evaluated-in-a-whole-blood-bactericidal-activity-model
#6
Claire M Naftalin, Rupangi Verma, Meera Gurumurthy, Qingshu Lu, Matthew Zimmerman, Benjamin Chaik Meng Yeo, Kin Hup Tan, Wenwei Lin, Buduo Yu, Véronique Dartois, Nicholas I Paton
Coadministering pyrazinamide (PZA) with the xanthine oxidase inhibitor allopurinol increases systemic levels of the active metabolite, pyrazinoic acid (POA), but the effects on bactericidal activity against tuberculosis are unknown. We randomized healthy volunteers to take a single dose of PZA (either 10 or 25 mg/kg of body weight) at the first visit and the same dose 7 days later, coadministered with allopurinol (100 mg daily; 2 days before to 1 day after the PZA dose). Blood was drawn at intervals until 48 h after each PZA dose, and drug levels were measured using liquid chromatography-tandem mass spectrometry...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28709849/effects-of-huperzin-a-on-the-beta-amyloid-accumulation-in-the-brain-and-skeletal-muscle-cells-of-a-rat-model-for-alzheimer-s-disease
#7
Cagatay Han Turkseven, Belgin Buyukakilli, Ebru Balli, Derya Yetkin, Mehmet Emin Erdal, Senay Gorucu Yilmaz, Leyla Sahin
AIMS: Alzheimer's Disease (AD) is characterized by a loss of cognitive function and also the accumulation of β-amyloid peptide (βAP) in the brain parenchyma, which plays an important role in this disease. However, it is often also associated with the non-cognitive symptoms such as loss of muscle function (Inclusion-Body Myositis-IBM). MAIN METHODS: Sprague-Dawley rats (13 weeks-n=68) were randomly assigned into five groups: Group C: Control; Group D: d-galactose; Group O+D: Bilateral oophorectomy+d-galactose; Group O: Bilateral oophorectomy; Group O+D+H: Bilateral oophorectomy+d-galactose+Hup-A...
September 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28659203/-a-baby-with-progressive-skin-lesions-on-the-scalp
#8
E A van der Rhee, M A Middelkamp-Hup, R Hoekzema
An eight-month-old girl was referred to the dermatologist with a progressive desquamative and purulent eruption on the scalp. Laboratory tests confirmed the diagnosis kerion celsi and the girl was successfully treated with an antimycoticum. Kerion celsi is a deep inflammatory fungal infection on the scalp. Early diagnosis is essential to prevent irreversible hair loss.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28631290/a-h2-oxidizing-1-2-3-trichlorobenzene-reducing-multienzyme-complex-isolated-from-the-obligately-organohalide-respiring-bacterium-dehalococcoides-mccartyi-strain-cbdb1
#9
Stefanie Hartwig, Nadya Dragomirova, Anja Kublik, Dominique Türkowsky, Martin von Bergen, Ute Lechner, Lorenz Adrian, R Gary Sawers
Dehalococcoides mccartyi is a small, slow-growing bacterium of the phylum Chloroflexi that conserves energy using aliphatic and aromatic organohalides as electron acceptors, and hydrogen as sole electron donor. A recent study identified a protein complex in the membrane of strain CBDB1 comprising a Hup hydrogenase, a complex iron-sulphur molybdoprotein and a reductive dehalogenase (RdhA) that catalyses reduction of 1,2,3,4-tetrachlorobenzene. Using a combination of size-exclusion chromatography, in-gel hydrogenase activity-staining, immunological analysis and mass spectrometry, we identified here a large molecular mass protein complex solubilized from the cytoplasmic membrane of D...
June 19, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28625948/anticholinesterase-activity-and-identification-of-huperzine-a-in-three-mexican-lycopods-huperzia-cuernavacensis-huperzia-dichotoma-and-huperzia-linifolia-lycopodiaceae
#10
Mariana Vázquez García, Gilsane Lino von Poser, Miriam Apel, Rosa Cerros Tlatilpa, Aniceto Mendoza-Ruiz, María Luisa Villarreal, Amelia Teresinha Henriques, Alexandre Cardoso Taketa
Huperzine A (Hup A), the alkaloid produced by the Chinese medicinal plant Huperzia serrata, has been documented to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase inhibitory (AChEI) activity. The search for anticholinesterase natural products, as well as for alternative sources of Hup A in Mexican lycopods, prompted us to investigate these plants. The action of methanolic and alkaloidal extracts of three Huperzia species (H. cuernavacensis, H. dichotoma, and H...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28558913/the-international-treatment-of-atopic-eczema-treat-registry-taskforce-an-initiative-to-harmonize-data-collection-across-national-atopic-eczema-photo-and-systemic-therapy-registries
#11
Phyllis I Spuls, Louise A A Gerbens, Christian J Apfelbacher, Dmitri Wall, Bernd W M Arents, Sebastien Barbarot, Amanda Roberts, Mette Deleuran, Maritza A Middelkamp-Hup, Christian Vestergaard, Stephan Weidinger, Jochen Schmitt, Alan D Irvine, Carsten Flohr
No abstract text is available yet for this article.
September 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28540173/self-microemulsifying-drug-delivery-system-for-improving-the-bioavailability-of-huperzine-a-by-lymphatic-uptake
#12
Fang Li, Rongfeng Hu, Bin Wang, Yun Gui, Gang Cheng, Song Gao, Lei Ye, Jihui Tang
Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion (SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration-time curve (AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension (P<0...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28443084/gene-expression-profiling-of-transcription-factors-of-helicobacter-pylori-under-different-environmental-conditions
#13
Miguel A De la Cruz, Miguel A Ares, Kristine von Bargen, Leonardo G Panunzi, Jessica Martínez-Cruz, Hilda A Valdez-Salazar, César Jiménez-Galicia, Javier Torres
Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and causes peptic ulcers and gastric carcinoma. H. pylori strain 26695 has a small genome (1.67 Mb), which codes for few known transcriptional regulators that control bacterial metabolism and virulence. We analyzed by qRT-PCR the expression of 16 transcriptional regulators in H. pylori 26695, including the three sigma factors under different environmental conditions. When bacteria were exposed to acidic pH, urea, nickel, or iron, the sigma factors were differentially expressed with a particularly strong induction of fliA...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28410614/factors-associated-with-high-utilization-in-a-safety-net-setting
#14
Julia Bell, Sara Turbow, Maura George, Mohammed K Ali
BACKGROUND: Patients with frequent hospital readmissions, or high-utilizer patients (HUPs), are a major driver of rising healthcare costs in the United States. This group has a significant burden of medical illness, but less is known about whether or how social determinants of health may drive their increased healthcare use and poor health outcomes. Our study aimed to define the population of HUPs at a large, safety-net hospital system, to understand how these patients differ from patients who are not HUPs, and to analyze how their demographic, medical, and social factors contribute to their healthcare use and mortality rates...
April 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28406297/binding-analysis-of-some-classical-acetylcholinesterase-inhibitors-insights-for-a-rational-design-using-free-energy-perturbation-method-calculations-with-qm-mm-md-simulations
#15
Érica C M Nascimento, Mónica Oliva, Katarzyna Świderek, João B L Martins, Juan Andrés
In the present study, the binding free energy of some classical inhibitors (DMT, DNP, GNT, HUP, THA) with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation (FEP) method based on hybrid quantum mechanics and molecular mechanics (QM/MM) potentials. The results highlight the key role of the van der Waals interaction for the inhibition process, since the contribution of this term to the binding free energy is almost as decisive as the electrostatic one. The analysis of the geometrical parameters and the interaction energy per residue along the QM/MM molecular dynamics (MD) simulations highlights the most relevant interactions in the different AChE-ligand systems, showing that the charged residues with a more prominent contribution to the interaction energy are Asp72 and Glu199, although the relative importance depends on the molecular size of the ligand...
April 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28361951/qualitative-and-quantitative-imaging-evaluation-of-renal-cell-carcinoma-subtypes-with-grating-based-x-ray-phase-contrast-ct
#16
Margarita Braunagel, Lorenz Birnbacher, Marian Willner, Mathias Marschner, Fabio De Marco, Manuel Viermetz, Susan Notohamiprodjo, Katharina Hellbach, Sigrid Auweter, Vera Link, Christine Woischke, Maximilian F Reiser, Franz Pfeiffer, Mike Notohamiprodjo, Julia Herzen
Current clinical imaging methods face limitations in the detection and correct characterization of different subtypes of renal cell carcinoma (RCC), while these are important for therapy and prognosis. The present study evaluates the potential of grating-based X-ray phase-contrast computed tomography (gbPC-CT) for visualization and characterization of human RCC subtypes. The imaging results for 23 ex vivo formalin-fixed human kidney specimens obtained with phase-contrast CT were compared to the results of the absorption-based CT (gbCT), clinical CT and a 3T MRI and validated using histology...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333342/activity-of-faropenem-with-and-without-rifampicin-against-mycobacterium-tuberculosis-evaluation-in-a-whole-blood-bactericidal-activity-trial
#17
Meera Gurumurthy, Rupangi Verma, Claire M Naftalin, Kim Hor Hee, Qingshu Lu, Kin Hup Tan, Simi Issac, Wenwei Lin, Angelia Tan, Kok-Yong Seng, Lawrence Soon-U Lee, Nicholas I Paton
Background: Faropenem has in vitro activity against Mycobacterium tuberculosis (Mtb) and shows synergy with rifampicin. We tested this in a whole-blood bactericidal activity (WBA) trial. Methods: We randomized healthy volunteers to receive a single oral dose of faropenem (600 mg) with amoxicillin/clavulanic acid (500/125 mg) ( n  =   8), rifampicin (10 mg/kg) ( n  =   14) or the combination rifampicin + faropenem + amoxicillin/clavulanic acid ( n  =   14)...
July 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28244177/the-histone-like-protein-hu-has-a-role-in-gene-expression-during-the-acid-adaptation-response-in-helicobacter-pylori
#18
Alhejandra Álvarez, Héctor Toledo
BACKGROUND: Gastritis, ulcers, and gastric malignancy have been linked to human gastric epithelial colonization by Helicobacter pylori. Characterization of the mechanisms by which H. pylori adapts to the human stomach environment is of crucial importance to understand H. pylori pathogenesis. MATERIAL AND METHODS: In an effort to extend our knowledge of these mechanisms, we used proteomic analysis and qRT-PCR to characterize the role of the histone-like protein HU in the response of H...
February 28, 2017: Helicobacter
https://www.readbyqxmd.com/read/28241851/treatment-of-atopic-eczema-treat-registry-taskforce-protocol-for-an-international-delphi-exercise-to-identify-a-core-set-of-domains-and-domain-items-for-national-atopic-eczema-registries
#19
Louise A A Gerbens, Aaron E Boyce, Dmitri Wall, Sebastien Barbarot, Richard J de Booij, Mette Deleuran, Maritza A Middelkamp-Hup, Amanda Roberts, Christian Vestergaard, Stephan Weidinger, Christian J Apfelbacher, Alan D Irvine, Jochen Schmitt, Paula R Williamson, Phyllis I Spuls, Carsten Flohr
BACKGROUND: Patients with moderate-to-severe atopic eczema (AE) often require photo- or systemic immunomodulatory therapies to induce disease remission and maintain long-term control. The current evidence to guide clinical management is small, despite the frequent and often off-label use of these treatments. Registries of patients on photo- and systemic immunomodulatory therapies could fill this gap, and the collection of a core set concerning these therapies in AE will allow direct comparisons across registries as well as data sharing and pooling...
February 27, 2017: Trials
https://www.readbyqxmd.com/read/28027773/ex-vivo-characterization-of-pathologic-fluids-with-quantitative-phase-contrast-computed-tomography
#20
Vivien Richter, Marian S Willner, John Henningsen, Lorenz Birnbacher, Mathias Marschner, Julia Herzen, Melanie A Kimm, Peter B Noe L, Ernst J Rummeny, Franz Pfeiffer, Alexander A Fingerle
PURPOSE: X-ray phase-contrast imaging (PCI) provides additional information beyond absorption characteristics by detecting the phase shift of the X-ray beam passing through material. The grating-based system works with standard polychromatic X-ray sources, promising a possible clinical implementation. PCI has been shown to provide additional information in soft-tissue samples. The aim of this study was to determine if ex vivo quantitative phase-contrast computed tomography (PCCT) may differentiate between pathologic fluid collections...
January 2017: European Journal of Radiology
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