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https://www.readbyqxmd.com/read/27812120/oxidized-phospholipid-oxpapc-activates-trpa1-and-contributes-to-chronic-inflammatory-pain-in-mice
#1
Boyi Liu, Yan Tai, Ana I Caceres, Satyanarayana Achanta, Shrilatha Balakrishna, Xiaomei Shao, Junfan Fang, Sven-Eric Jordt
Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as septic inflammation and acute lung injury to exert pro- or anti-inflammatory effects. It is currently unknown whether OxPAPC also contributes to inflammatory pain and peripheral neuronal excitability in these conditions. Here, we observed that OxPAPC dose-dependently and selectively activated human TRPA1 nociceptive ion channels expressed in HEK293 cells in vitro, without any effect on other TRP channels, including TRPV1, TRPV4 and TRPM8...
2016: PloS One
https://www.readbyqxmd.com/read/27751881/role-of-transition-metals-present-in-air-particulate-matter-on-lung-oxygen-metabolism
#2
Natalia D Magnani, Timoteo Marchini, Mariana Garcés, Andrea Mebert, Lourdes Cáceres, Luis Diaz, Martín Desimone, Pablo A Evelson
Several epidemiological studies have shown a positive correlation between daily increases in airborne particulate matter (PM) concentration and the occurrence of respiratory and cardiovascular diseases. Transition metals present in air PM were associated with adverse health effects after PM exposure. The aim of this work was to study lung O2 metabolism after an acute exposure to transition metal-coated nanoparticles (NPs). Female Swiss mice (25g) were intranasally instilled with a suspension of silica NP containing Ni (II), Cd (II), Fe (III), or Cr (VI) at 0, 0...
October 14, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27686458/esicm-lives-2016-part-one-milan-italy-1-5-october-2016
#3
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, B Ziaian, M Masjedi, C Fleischmann, D O Thomas-Rueddel, A Schettler, D Schwarzkopf, A Stacke, K Reinhart, E Filipe, A Escoval, A Martins, P Sousa, N Velez, E Viegas, E Tomas, G Snell, R Matsa, T T S Paary, M S Kalaiselvan, A M Cavalheiro, L L Rocha, C S Vallone, A Tonilo, M D S Lobato, D T Malheiro, G Sussumo, N M Lucino, F Zand, V D Rosenthal, M Masjedi, G Sabetian, B Maghsudi, M Ghorbani, A Sanaei Dashti, A Yousefipour, J R Goodall, M Williamson, E Tant, N Thomas, C Balci, C Gonen, E Haftacı, H Gurarda, E Karaca, B Paldusová, I Zýková, D Šímová, S Houston, L D'Antona, J Lloyd, V Garnelo-Rey, M Sosic, V Sotosek-Tokmazic, J Kuharic, I Antoncic, S Dunatov, A Sustic, C T Chong, M Sim, T Lyovarin, F M Acosta Díaz, S Narbona Galdó, M Muñoz Garach, O Moreno Romero, A M Pérez Bailón, A Carranza Pinel, M Colmenero, A Gritsan, A Gazenkampf, E Korchagin, N Dovbish, R M Lee, M P P Lim, C T Chong, B C L Lim, J J See, R Assis, F Filipe, N Lopes, L Pessoa, T Pereira, N Catorze, M S Aydogan, C Aldasoro, P Marchio, A Jorda, M D Mauricio, S Guerra-Ojeda, M Gimeno-Raga, M Colque-Cano, A Bertomeu-Artecero, M Aldasoro, S L Valles, D Tonon, T Triglia, J C Martin, M C Alessi, N Bruder, P Garrigue, L Velly, S Spina, V Scaravilli, C Marzorati, E Colombo, D Savo, A Vargiolu, G Cavenaghi, G Citerio, A H V Andrade, P Bulgarelli, J A P Araujo, V Gonzalez, V A Souza, A Costa, C Massant, C A C Abreu Filho, R A Morbeck, L E Burgo, R van Groenendael, L T van Eijk, G P Leijte, B Koeneman, M Kox, P Pickkers, A García-de la Torre, M de la Torre-Prados, A Fernández-Porcel, C Rueda-Molina, P Nuevo-Ortega, T Tsvetanova-Spasova, E Cámara-Sola, A García-Alcántara, L Salido-Díaz, X Liao, T Feng, J Zhang, X Cao, Q Wu, Z Xie, H Li, Y Kang, M S Winkler, A Nierhaus, E Mudersbach, A Bauer, L Robbe, C Zahrte, E Schwedhelm, S Kluge, C Zöllner, B Morton, E Mitsi, S H Pennington, J Reine, A D Wright, R Parker, I D Welters, J D Blakey, G Rajam, E W Ades, D M Ferreira, D Wang, A Kadioglu, S B Gordon, R Koch, M Kox, J Rahamat-Langedoen, J Schloesser, M de Jonge, P Pickkers, J Bringue, R Guillamat-Prats, E Torrents, M L Martinez, M Camprubí-Rimblas, A Artigas, L Blanch, S Y Park, Y B Park, D K Song, S Shrestha, S H Park, Y Koh, M J Park, C W Hong, O Lesur, D Coquerel, X Sainsily, J Cote, T Söllradl, A Murza, L Dumont, R Dumaine, M Grandbois, P Sarret, E Marsault, D Salvail, M Auger-Messier, F Chagnon, M P Lauretta, E Greco, A Dyson, M Singer, S Preau, M Ambler, A Sigurta, S Saeed, M Singer, L Topcu Sarıca, N Zibandeh, D Genc, F Gul, T Akkoc, E Kombak, L Cinel, T Akkoc, I Cinel, S J Pollen, N Arulkumaran, M Singer, H D Torrance, E R Longbottom, G Warnes, C J Hinds, D J Pennington, K Brohi, M J O'Dwyer, H Y Kim, S Na, J Kim, Y F Chang, A Chao, P Y Shih, C T Lee, Y C Yeh, L W Chen, M Adriaanse, Z Trogrlic, E Ista, H Lingsma, W Rietdijk, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, D A M P J Gommers, M van der Jagt, S Funcke, S Sauerlaender, B Saugel, H Pinnschmidt, D A Reuter, R Nitzschke, S Perbet, C Biboulet, A Lenoire, D Bourdeaux, B Pereira, B Plaud, J E Bazin, V Sautou, A Mebazaa, J M Constantin, M Legrand, Y Boyko, P Jennum, M Nikolic, H Oerding, R Holst, P Toft, H K Nedergaard, T Haberlandt, H I Jensen, P Toft, S Park, S Kim, Y J Cho, Y J Lim, A Chan, S Tang, S L Nunes, S Forsberg, H Blomqvist, L Berggren, M Sörberg, T Sarapohja, C J Wickerts, J G M Hofhuis, L Rose, B Blackwood, E Akerman, J Mcgaughey, I Egerod, M Fossum, H Foss, E Georgiou, H J Graff, M Kalafati, R Sperlinga, A Schafer, A G Wojnicka, P E Spronk, F Zand, F Khalili, R Afshari, G Sabetian, M Masjedi, B Maghsudi, H Haddad Khodaei, S Javadpour, P Petramfar, S Nasimi, A Vazin, B Ziaian, H Tabei, A Gunther, J O Hansen, P Sackey, H Storm, J Bernhardsson, Ø Sundin, A Bjärtå, A Bienert, P Smuszkiewicz, P Wiczling, K Przybylowski, A Borsuk, I Trojanowska, J Matysiak, Z Kokot, M Paterska, E Grzeskowiak, A Messina, E Bonicolini, D Colombo, G Moro, S Romagnoli, A R De Gaudio, F Della Corte, S M Romano, J A Silversides, E Major, E E Mann, A J Ferguson, D F Mcauley, J C Marshall, B Blackwood, E Fan, J A Diaz-Rodriguez, R Silva-Medina, E Gomez-Sandoval, N Gomez-Gonzalez, R Soriano-Orozco, P L Gonzalez-Carrillo, M Hernández-Flores, K Pilarczyk, J Lubarksi, D Wendt, F Dusse, J Günter, B Huschens, E Demircioglu, H Jakob, A Palmaccio, A M Dell'Anna, D L Grieco, F Torrini, C Iaquaniello, F Bongiovanni, M Antonelli, L Toscani, D Antonakaki, D Bastoni, H D Aya, A Rhodes, M Cecconi, M Jozwiak, F Depret, J L Teboul, J Alphonsine, C Lai, C Richard, X Monnet, I László, G Demeter, N Öveges, K Tánczos, M Németh, D Trásy, I Kertmegi, D Érces, B Tudor, J Kaszaki, Z Molnár, A Hasanin, A Lotfy, A El-Adawy, H Nassar, S Mahmoud, A Abougabal, A Mukhtar, F Quinty, S Habchi, A Luzi, E Antok, G Hernandez, B Lara, L Enberg, M Ortega, P Leon, C Kripper, P Aguilera, E Kattan, J Bakker, W Huber, M Lehmann, S Sakka, B Bein, R M Schmid, J Preti, J Creteur, A Herpain, J Marc, E Zogheib, F Trojette, S Bar, L Kontar, D Titeca, J Richecoeur, B Gelee, N Verrier, R Mercier, E Lorne, J Maizel, H Dupont, M Slama, M E Abdelfattah, A Eladawy, M A Ali Elsayed, A Mukhtar, A Pedraza Montenegro, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, G Camarena Alejo, A Rugerio Cabrera, A A Tanaka Montoya, C Lee, F Hatib, M Cannesson, P Theerawit, T Morasert, Y Sutherasan, G Zani, S Mescolini, M Diamanti, R Righetti, A Scaramuzza, M Papetti, M Terenzoni, C Gecele, M Fusari, K A Hakim, A Chaari, M Ismail, A H Elsaka, T M Mahmoud, K Bousselmi, V Kauts, W F Casey, S D Hutchings, D Naumann, J Wendon, S Watts, E Kirkman, Z Jian, S Buddi, C Lee, J Settels, F Hatib, M R Pinsky, P Bertini, F Guarracino, C Trepte, P Richter, S A Haas, V Eichhorn, J C Kubitz, D A Reuter, M S Soliman, W I Hamimy, A Z Fouad, A M Mukhtar, M Charlton, L Tonks, L Mclelland, T J Coats, J P Thompson, M R Sims, D Williams, D Z Roushdy, R A Soliman, R A Nahas, M Y Arafa, W T Hung, C C Chiang, W C Huang, K C Lin, S C Lin, C C Cheng, P L Kang, S R Wann, G Y Mar, C P Liu, M Lopez Carranza, H Sancho Fernandez, J A Sanchez Roman, F Lucena, A Campanario Garcia, A Loza Vazquez, A Lesmes Serrano, L Sayagues Moreira, R Vidal-Perez, U Anido Herranz, J M Garcia Acuna, C Pena Gil, J L Garcia Allut, P Rascado Sedes, C Martin Lopez, E Saborido Paz, C Galban Rodriguez, J R Gonzalez-Juanatey, A Vallejo-Baez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, J Aron, R Marharaj, K Gervasio, M Bottiroli, M Mondino, D De Caria, A Calini, E Montrasio, F Milazzo, M P Gagliardone, A Vallejo-Báez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, L Sayagues Moreira, R Vidal-Perez, U Anido, C Pena Gil, J M Garcia Acuna, P Rascado Sedes, C Martin Lopez, E Saborido Paz, J L Garcia Allut, C Galban Rodriguez, J R Gonzalez-Juanatey, Y Hamdaoui, A Khedher, M Cheikh-Bouhlel, J Ayachi, K Meddeb, N Sma, N Fraj, N Ben Aicha, S Romdhani, R Bouneb, I Chouchene, M Boussarsar, M P R D L Dela Cruz, J M Bernardo, F Galfo, A Dyson, M Singer, A Marino, A Dyson, M Singer, C C Chao, P Hou, W C Huang, C C Hung, C H Chiang, W T Hung, K C Lin, S C Lin, Y J Liou, S M Hung, Y S Lin, C C Cheng, F Y Kuo, K R Chiou, C J Chen, L S Yan, C Y Liu, H H Wang, P L Kang, H L Chen, C K Ho, G Y Mar, C P Liu, S Grewal, S Gopal, C Corbett, A Wilson, J Capps, W Ayoub, A Lomas, S Ghani, J Moore, D Atkinson, M Sharman, W Swinnen, J Pauwels, K Mignolet, E Pannier, A Koch, T Sarens, W Temmerman, A M Elmenshawy, A M Fayed, M Elboriuny, E Hamdy, E Zakaria, A C Falk, A Petosic, K Olafsen, H Wøien, H Flaatten, K Sunde, J J Cáceres Agra, J L Santana Cabrera, J D Martín Santana, L Melián Alzola, H Rodríguez Pérez, T Castro Pires, H Calderón, A Pereira, S Castro, C Granja, I Norkiene, I Urbanaviciute, G Kezyte, D Ringaitiene, T Jovaisa, G Vogel, U B Johansson, A Sandgren, C Svensen, E Joelsson-Alm, M A Leite, L D Murbach, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, L D Murbach, M A Leite, E F Osaku, J Barreto, S T Duarte, S Taba, D Miglioranza, D P Gund, C F Lordani, C R L M Costa, S M Ogasawara, A C Jorge, P A D Duarte, H Vollmer, M Gager, C Waldmann, A T Mazzeo, R Tesio, C Filippini, M E Vallero, C Giolitti, S Caccia, M Medugno, T Tenaglia, R Rosato, I Mastromauro, L Brazzi, P P Terragni, R Urbino, V Fanelli, V M Ranieri, L Mascia, J Ballantyne, L Paton, A Mackay, P Perez-Teran, O Roca, J C Ruiz-Rodriguez, A Zapatero, J Serra, J R Masclans, S Bianzina, P Cornara, G Rodi, G Tavazzi, M Pozzi, G A Iotti, F Mojoli, A Braschi, A Vishnu, D Buche, R Pande, D L J Moolenaar, F Bakhshi-Raiez, D A Dongelmans, N F de Keizer, D W de Lange, I Fuentes Fernández, D Martínez Baño, J L Buendía Moreno, R Jara Rubio, J Scott, D Phelan, D Morely, J O'Flynn, P Stapleton, M Lynch, B Marsh, E Carton, C O'Loughlin, K C Cheng, M I Sung, M O Elghonemi, M H Saleh, T S Meyhoff, M Krag, P B Hjortrup, A Perner, M H Møller, T Öhman, T Sigmundsson, E Redondo, M Hallbäck, F Suarez-Sipmann, H Björne, C Hällsjö Sander, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, M Guanziroli, G Vergani, T Tonetti, I Tomic, A Colombo, F Crimella, E Carlesso, A Colombo, V Gasparovic, L Gattinoni, R El-Sherif, M Abd Al-Basser, A Raafat, A El-Sherif, F D Simonis, L R A Schouten, O L Cremer, D S Y Ong, G Amoruso, G Cinnella, M J Schultz, L D J Bos, W Huber, P Schmidle, M Findeisen, P Hoppmann, J Jaitner, F Brettner, R M Schmid, T Lahmer, E Festic, G Rajagopalan, V Bansal, R Frank, R Hinds, J Levitt, S Siddiqui, J P Gilbert, K Sim, C H Wang, H C Hu, I J Li, W R Tang, K C Kao, P Persona, A De Cassai, M Franco, F Facchin, C Ori, S Rossi, A Goffi, S H Li, H C Hu, L C Chiu, C Y Hung, C H Chang, K C Kao, B Llorente Ruiz, J Lujan Varas, R Molina Montero, C Pintado Delgado, O Navarrete, M Vazquez Mezquita, E Alonso Peces, M A M Nakamura, L A Hajjar, F R B G Galas, T A Ortiz, M B P Amato, L Bitker, N Costes, D Le Bars, F Lavenne, D Mojgan, J C Richard, C Chiurazzi, M Cressoni, D Massari, M Guanziroli, G Vergani, M Gotti, M Brioni, I Algieri, P Cadringher, T Tonetti, D Chiumello, L Gattinoni, A Zerman, M Türkoğlu, G Arık, F Yıldırım, Z Güllü, I Kara, N Boyacı, B Basarık Aydoğan, Ü Gaygısız, K Gönderen, G Aygencel, M Aydoğdu, Z Ülger, G Gürsel, J Riera, C Maldonado Toral, C Mazo, M Martínez, J Baldirà, L Lagunes, A Roman, M Deu, J Rello, D J Levine, R M Mohus, Å Askim, J Paulsen, A Mehl, A T Dewan, J K Damås, E Solligård, B O Åsvold, J Paulsen, Å Askim, R M Mohus, A Mehl, A DeWan, E Solligård, J K Damås, B O Åsvold, O Aktepe, A Kara, H Yeter, A Topeli, M Norrenberg, M Devroey, H Khader, J C Preiser, Z Tang, C Qiu, L Tong, C Cai, M Theodorakopoulou, A Diamantakis, M Kontogiorgi, E Chrysanthopoulou, T Christodoulopoulou, F Frantzeskaki, M Lygnos, O Apostolopoulou, A Armaganidis, J Y Moon, M R Park, I S Kwon, G R Chon, J Y Ahn, S J Kwon, Y J Chang, J Y Lee, S Y Yoon, J W Lee, M Kostalas, J Mckinlay, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, N D Altintas, S Izdes, O Keremoglu, A Alkan, S Neselioglu, O Erel, N Tardif, T Gustafsson, O Rooyackers, K N MacEachern, M Traille, I Bromberg, S E Lapinsky, M J Moore, Z Tang, C Cai, L Tong, J L García-Garmendia, F Villarrasa-Clemente, F Maroto-Monserrat, O Rufo-Tejeiro, V Jorge-Amigo, M Sánchez-Santamaría, C Colón-Pallarés, A Barrero-Almodóvar, S Gallego-Lara, C T Anthon, R B Müller, N Haase, K Møller, P B Hjortrup, J Wetterslev, A Perner, M Nakanishi, A Kuriyama, T Fukuoka, M A Abd El Halim, M H Elsaid Hafez, A M Moktar, A Eladawy, H M Elazizy, K Abdel Hakim, A Chaari, M Elbahr, M Ismail, T Mahmoud, V Kauts, K Bousselmi, E Khalil, W Casey, S H Zaky, A Rizk, M O Elghonemi, R Ahmed, J C F Vieira, R B Souza, A M A Liberatore, I H J Koh, G A Ospina-Tascón, A F Garcia Marin, G J Echeverry, W F Bermudez, H J Madriñan-Navia, J D Valencia, E Quiñonez, A Marulanda, C A Arango-Dávila, A Bruhn, G Hernandez, D De Backer, D Orbegozo Cortes, F Su, J L Vincent, J Creteur, L Tullo, L Mirabella, P Di Molfetta, G Cinnella, M Dambrosio, C Villavicencio Lujan, J Leache Irigoyen, M Cartanya Ferré, R Carbonell García, A Mukhtar, M Ahmed, M El Ayashi, A Hasanin, E Ayman, M Salem, A Eladawy, S Fathy, H Nassar, A Zaghlol, M F Aguilar Arzapalo, Å Valsø, K Sunde, T Rustøen, I Schou-Bredal, L Skogstad, K Tøien, C Padilla, Y Palmeiro, W Egbaria, R Kigli, B Maertens, K Blot, S Blot, E Santana-Santos, E R Dos Santos, R E D L Ferretti-Rebustini, R D C C D O Dos Santos, R G S Verardino, L A Bortolotto, A M Doyle, I Naldrett, J Tillman, S Price, S Shrestha, P Pearson, J Greaves, D Goodall, A Berry, A Richardson, G O Odundo, P Omengo, P Obonyo, N M Chanzu, R Kleinpell, S J Sarris, P Nedved, M Heitschmidt, H Ben-Ghezala, S Snouda, S Djobbi, H Ben-Ghezala, S Snouda, L Rose, N K J Adhikari, D Leasa, D Fergusson, D A Mckim, J Weblin, O Tucker, D McWilliams, F Doesburg, F Cnossen, W Dieperink, W Bult, M W N Nijsten, G A Galvez-Blanco, E Monares Zepeda, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, J Santos Stroud, R Thomson, M Llaurado-Serra, A Lobo-Civico, M Pi-Guerrero, I Blanco-Sanchez, A Piñol-Tena, C Paños-Espinosa, Y Alabart-Segura, B Coloma-Gomez, A Fernandez-Blanco, F Braga-Dias, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, R Prada, P Juárez, R Argandoña, J J Díaz, C Sánchez Ramirez, P Saavedra, S Ruiz Santana, O Obukhova, S Kashiya, I A Kurmukov, A M Pronina, P Simeone, L Puybasset, G Auzias, O Coulon, B Lesimple, G Torkomian, L Velly, A Bienert, A Bartkowska-Sniatkowska, P Wiczling, O Szerkus, D Siluk, J Bartkowiak-Wieczorek, J Rosada-Kurasinska, J Warzybok, A Borsuk, R Kaliszan, E Grzeskowiak, C Hernandez Caballero, S Roberts, G Isgro, D Hall, G Guillaume, O Passouant, F Dumas, W Bougouin, B Champigneulle, M Arnaout, J Chelly, J D Chiche, O Varenne, J P Mira, E Marijon, A Cariou, M Beerepoot, H R Touw, K Parlevliet, C Boer, P W Elbers, P R Tuinman, Á J Roldán Reina, Y Corcia Palomo, R Martín Bermúdez, L Martín Villén, I Palacios García, J R Naranjo Izurieta, J B Pérez Bernal, F J Jiménez Jiménez, F Cota-Delgado, M V de la Torre-Prados, A Fernández-Porcel, P Nuevo-Ortega, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, T Kaneko, H Tanaka, M Kamikawa, R Karashima, S Iwashita, H Irie, S Kasaoka, O Arola, R Laitio, A Saraste, J Airaksinen, M Pietilä, M Hynninen, J Wennervirta, M Bäcklund, E Ylikoski, P Silvasti, E Nukarinen, J Grönlund, V P Harjola, J Niiranen, K Korpi, M Varpula, R O Roine, T Laitio, S Salah, B G Hassen, A Mohamed Fehmi, S Kim, Y C Hsu, J Barea-Mendoza, C García-Fuentes, M Castillo-Jaramillo, H Dominguez-Aguado, R Viejo-Moreno, L Terceros-Almanza, S Bermejo Aznárez, C Mudarra-Reche, W Xu, M Chico-Fernández, J C Montejo-González, K Crewdson, M Thomas, M Merghani, L Fenner, P Morgan, D Lockey, E J van Lieshout, B Oomen, J M Binnekade, D A Dongelmans, R J de Haan, N P Juffermans, M B Vroom, R Algarte, L Martínez, B Sánchez, I Romero, F Martínez, S Quintana, J Trenado, O Sheikh, D Pogson, R Clinton, F Riccio, L Gemmell, A MacKay, A Arthur, L Young, A Sinclair, D Markopoulou, K Venetsanou, L Filippou, E Salla, S Stratouli, I Alamanos, A H Guirgis, R Gutiérrez Rodriguez, M J Furones Lorente, I Macias Guarasa, A Ukere, S Meisner, G Greiwe, B Opitz, D Benten, B Nashan, L Fischer, C J C Trepte, D A Reuter, S A Haas, C R Behem, G Tavazzi, B Ana, A Vazir, D Gibson, S Price, M Masjedi, M R Hadavi, M Riahi Alam, M R Sasani, N Parenti, F Agrusta, C Palazzi, B Pifferi, R Sganzerla, F Tagliazucchi, A Luciani, M Möller, J Müller-Engelmann, G Montag, P Adams, C Lange, J Neuzner, R Gradaus, K H Wodack, F Thürk, A D Waldmann, M F Grässler, S Nishimoto, S H Böhm, E Kaniusas, D A Reuter, C J Trepte, T Sigmundsson, T Öhman, E Redondo, M Hallbäck, M Wallin, F Suarez Sipman, A Oldner, C Hällsjö Sander, H Björne, L Colinas, G Hernandez, R Vicho, M Serna, R Cuena, A Canabal, A Chaari, K Abdel Hakim, M Etman, M El Bahr, A El Sakka, K Bousselmi, A Arali, V Kauts, W F Casey, O Bond, P De Santis, E Iesu, F Franchi, J L Vincent, J Creteur, S Scolletta, F S Taccone, Z Marutyan, L Hamidova, A Shakotko, V Movsisyan, I Uysupova, A Evdokimov, S Petrikov, C Gonen, E Haftacı, C Balci, F J Redondo Calvo, N Bejarano, V Baladron, R Villazala, J Redondo, D Padilla, P Villarejo, A Akcan-Arikan, C E Kennedy, M F Aguilar Arzapalo, C Gomez-Gonzalez, S Mas-Font, A Puppo-Moreno, M Herrera-Gutierrez, M Garcia-Garcia, S Aldunate-Calvo, E P Plata-Menchaca, X L Pérez-Fernández, M Estruch, A Betbese-Roig, P Cárdenas Campos, M Rojas Lora, N D Toapanta Gaibor, R S Contreras Medina, V D Gumucio Sanguino, E J Casanova, J Sabater Riera, K Kritmetapak, S Peerapornratana, P Kittiskulnam, T Dissayabutra, K Tiranathanagul, P Susantithapong, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, N Srisawat, T Winkelmann, T Busch, J Meixensberger, S Bercker, E M Flores Cabeza, M Sánchez Sánchez, N Cáceres Giménez, C Gutierrez Melón, E Herrero de Lucas, P Millán Estañ, M Hernández Bernal, A Garcia de Lorenzo Y Mateos, B Ergin, P Guerci, P A C Specht, Y Ince, C Ince, M Balik, M Zakharchenko, F Los, H Brodska, C de Tymowski, P Augustin, M Desmard, P Montravers, S N Stapel, R de Boer, H M Oudemans, A Hollinger, T Schweingruber, F Jockers, M Dickenmann, M Siegemund, N Runciman, M Ralston, R Appleton, T Mauri, L Alban, C Turrini, T Sasso, T Langer, M Panigada, P Taccone, E Carlesso, C Marenghi, G Grasselli, A Pesenti, P Wibart, T Reginault, M Garcia, B Barbrel, A Benard, C Bader, F Vargas, H N Bui, G Hilbert, J M Serrano Simón, P Carmona Sánchez, F Ruiz Ferrón, M García de Acilu, J Marin, V Antonia, L Ruano, M Monica, R Ferrer, J R Masclans, O Roca, G Hong, D H Kim, Y S Kim, J S Park, Y K Jee, Z Yu Xiang, W Jia-Xing, W Xiao Dan, N Wen Long, W Yu, Z Yan, X Cheng, T Kobayashi, Y Onodera, R Akimoto, A Sugiura, H Suzuki, M Iwabuchi, M Nakane, K Kawamae, P Carmona Sanchez, M D Bautista Rodriguez, M Rodriguez Delgado, V Martínez de Pinillos Sánchez, A Mula Gómez, J M Serrano Simón, P Beuret, C Fortes, M Lauer, M Reboul, J C Chakarian, X Fabre, B Philippon-Jouve, S Devillez, M Clerc, N Rittayamai, M Sklar, M Dres, M Rauseo, C Campbell, B West, D E Tullis, L Brochard, Y Onodera, R Akimoto, H Suzuki, M Okada, M Nakane, K Kawamae, N Ahmad, M Wood, A Glossop, J Higuera Lucas, A Blandino Ortiz, D Cabestrero Alonso, R De Pablo Sánchez, L Rey González, R Costa, G Spinazzola, A Pizza, G Ferrone, M Rossi, M Antonelli, G Conti, H Ribeiro, J Alves, M Sousa, P Reis, C S Socolovsky, R P Cauley, J E Frankel, A L Beam, K O Olaniran, F K Gibbons, K B Christopher, J Pennington, P Zolfaghari, H S King, H H Y Kong, H P Shum, W W Yan, C Kaymak, N Okumus, A Sari, B Erdogdu, S Aksun, H Basar, A Ozcan, N Ozcan, D Oztuna, J A Malmgren, S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27195300/steroid-tumor-environment-in-male-and-female-mice-model-of-canine-and-human-inflammatory-breast-cancer
#4
Sara Caceres, Laura Peña, Gema Silvan, Maria J Illera, Wendy A Woodward, James M Reuben, Juan C Illera
Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC) and has been proposed as a good model for studying the human disease. The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and identify the hormonal tumor environment. To perform the study sixty 6-8-week-old male and female mice were inoculated subcutaneously with a suspension of 10(6)IPC-366 and SUM149 cells. Tumors and serum were collected and used for hormonal analysis...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26471143/multiple-criteria-optimization-joint-analyses-of-microarray-experiments-in-lung-cancer-from-existing-microarray-data-to-new-knowledge
#5
Katia I Camacho-Cáceres, Juan C Acevedo-Díaz, Lynn M Pérez-Marty, Michael Ortiz, Juan Irizarry, Mauricio Cabrera-Ríos, Clara E Isaza
Microarrays can provide large amounts of data for genetic relative expression in illnesses of interest such as cancer in short time. These data, however, are stored and often times abandoned when new experimental technologies arrive. This work reexamines lung cancer microarray data with a novel multiple criteria optimization-based strategy aiming to detect highly differentially expressed genes. This strategy does not require any adjustment of parameters by the user and is capable to handle multiple and incommensurate units across microarrays...
December 2015: Cancer Medicine
https://www.readbyqxmd.com/read/26381991/biotransformation-of-magnetic-nanoparticles-as-a-function-of-coating-in-a-rat-model
#6
A Ruiz, L Gutiérrez, P R Cáceres-Vélez, D Santos, S B Chaves, M L Fascineli, M P Garcia, R B Azevedo, M P Morales
Long-term in vivo studies in murine models have shown that DMSA-coated nanoparticles accumulate in spleen, liver and lung tissues during extended periods of time (at least up to 3 months) without any significant signs of toxicity detected. During that time, nanoparticles undergo a process of biotransformation either by reducing the size or the particle aggregation or both. Using a rat model, we have evaluated the transformations of magnetic nanoparticles injected at low doses. Particles with two different coatings, dimercaptosuccinic acid (NP-DMSA) and polyethylene glycol (NP-PEG-(NH2)2) have been administered to animals, to evaluate the role of coating in the degradation of the particles...
October 21, 2015: Nanoscale
https://www.readbyqxmd.com/read/26267259/the-skin-of-commerson-s-dolphins-cephalorhynchus-commersonii-as-a-biomonitor-of-mercury-and-selenium-in-subantarctic-waters
#7
Iris Cáceres-Saez, R Natalie P Goodall, Natalia A Dellabianca, H Luis Cappozzo, Sergio Ribeiro Guevara
The skin of bycaught Commerson's dolphins was tested for mercury (Hg) and selenium (Se) biomonitoring in Subantarctic environments. The correlation of levels detected in the skin with those found in internal tissues - lung, liver, kidney and muscle - was assessed to evaluate how skin represents internal Hg and Se distribution for monitoring purposes. Mercury in skin had a concentration range of 0.68-3.11 μg g(-1) dry weight (DW), while Se had a higher concentration range of 74.3-124.5 μg g(-1) DW. There was no significant correlation between selenium levels in any of the analyzed tissues...
November 2015: Chemosphere
https://www.readbyqxmd.com/read/26045797/biomarkers-of-erlotinib-response-in-non-small-cell-lung-cancer-tumors-that-do-not-harbor-the-more-common-epidermal-growth-factor-receptor-mutations
#8
Blanca D López-Ayllón, Javier de Castro-Carpeño, Carlos Rodriguez, Olga Pernía, Inmaculada Ibañez de Cáceres, Cristobal Belda-Iniesta, Rosario Perona, Leandro Sastre
Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancers, which are the leading cause of cancer-related deaths in the world. Tyrosine kinase inhibitors such as erlotinib represent one therapeutic options presently recommended for tumors produced by activating mutations in the gene coding of epidermal growth factor receptor (EGFR). The aim of this study is the identification of possible biomarkers for tumor sensitivity to erlotinib in the absence of the main EGFR mutations. The erlotinib sensitivity of cells isolated from 41 untreated NSCLC patients was determined and compared with the presence of the more frequent EGFR mutations...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26035979/primary-venous-and-malignancy-is-there-any-relationship
#9
Luis Cotto Santana, Williams Caceres Perkins
UNLABELLED: Deep venous thrombosis and pulmonary embolism can be the first manifestation of cancer. In light of this association screening for cancer has been proposed in patients with primary VTE to identify an undiagnosed malignancy. METHOD: Descriptive, retrospective record review that includes 3244 patients from VA San Juan Caribbean system with diagnosis of lung (small and non-small cell), prostate, colon, rectum, liver, stomach, esophagus, pancreas and breast cancer, lymphoma or leukemia from 2005 to 2010 evaluated for primary VTE during five years prior to their malignancy diagnosis...
January 2015: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/25807360/establishment-and-characterization-of-a-new-cell-line-of-canine-inflammatory-mammary-cancer-ipc-366
#10
Sara Caceres, Laura Peña, Paloma J de Andres, Maria J Illera, Mirtha S Lopez, Wendy A Woodward, James M Reuben, Juan C Illera
Canine inflammatory mammary cancer (IMC) shares epidemiologic, histopathological and clinical characteristics with the disease in humans and has been proposed as a natural model for human inflammatory breast cancer (IBC). The aim of this study was to characterize a new cell line from IMC (IPC-366) for the comparative study of both IMC and IBC. Tumors cells from a female dog with clinical IMC were collected. The cells were grown under adherent conditions. The growth, cytological, ultrastructural and immunohistochemical (IHC) characteristics of IPC-366 were evaluated...
2015: PloS One
https://www.readbyqxmd.com/read/25675351/mycobacterium-abscessus-morphotype-comparison-in-a-murine-model
#11
Lindsay J Caverly, Silvia M Caceres, Cori Fratelli, Carrie Happoldt, Kelley M Kidwell, Kenneth C Malcolm, Jerry A Nick, David P Nichols
Pulmonary infections with Mycobacterium abscessus (M. abscessus) are increasingly prevalent in patients with lung diseases such as cystic fibrosis. M. abscessus exists in two morphotypes, smooth and rough, but the impact of morphotype on virulence is unclear. We developed an immune competent mouse model of pulmonary M. abscessus infection and tested the differences in host inflammatory response between the morphotypes of M. abscessus. Smooth and rough morphotypes of M. abscessus were isolated from the same American Type Culture Collection strain...
2015: PloS One
https://www.readbyqxmd.com/read/25482372/methylation-status-of-igfbp-3-as-a-useful-clinical-tool-for-deciding-on-a-concomitant-radiotherapy
#12
Olga Pernía, Cristobal Belda-Iniesta, Veronica Pulido, María Cortes-Sempere, Carlos Rodriguez, Olga Vera, Javier Soto, Julia Jiménez, Alvaro Taus, Federico Rojo, Edurne Arriola, Ana Rovira, Joan Albanell, M Teresa Macías, Javier de Castro, Rosario Perona, Inmaculada Ibañez de Caceres
The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we found in vitro evidence that linked the presence of an unmethylated promoter with poor response to radiation. Our data also indicate that radiation might sensitize chemotherapy-resistant cells by reactivating IGFBP-3-expression through promoter demethylation, inactivating the PI3K/AKT pathway. We also explored the IGFBP-3 methylation effect on overall survival (OS) in a population of 40 NSCLC patients who received adjuvant therapy after R0 surgery...
November 2014: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/25182651/enhanced-in-vitro-formation-and-antibiotic-resistance-of-nonattached-pseudomonas-aeruginosa-aggregates-through-incorporation-of-neutrophil-products
#13
Silvia M Caceres, Kenneth C Malcolm, Jennifer L Taylor-Cousar, David P Nichols, Milene T Saavedra, Donna L Bratton, Samuel M Moskowitz, Jane L Burns, Jerry A Nick
Pseudomonas aeruginosa is a major pathogen in cystic fibrosis (CF) lung disease. Children with CF are routinely exposed to P. aeruginosa from the natural environment, and by adulthood, 80% of patients are chronically infected. P. aeruginosa in the CF airway exhibits a unique biofilm-like structure, where it grows in small clusters or aggregates of bacteria in association with abundant polymers of neutrophil-derived components F-actin and DNA, among other components. These aggregates differ substantially in size and appearance compared to surface-attached in vitro biofilm models classically utilized for studies but are believed to share properties of surface-attached biofilms, including antibiotic resistance...
November 2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24961511/cancer-stem-cells-and-cisplatin-resistant-cells-isolated-from-non-small-lung-cancer-cell-lines-constitute-related-cell-populations
#14
Blanca D Lopez-Ayllon, Veronica Moncho-Amor, Ander Abarrategi, Inmaculada Ibañez de Cáceres, Javier Castro-Carpeño, Cristobal Belda-Iniesta, Rosario Perona, Leandro Sastre
Lung cancer is the top cause of cancer-related deceases. One of the reasons is the development of resistance to the chemotherapy treatment. In particular, cancer stem cells (CSCs), can escape treatment and regenerate the bulk of the tumor. In this article, we describe a comparison between cancer cells resistant to cisplatin and CSCs, both derived from the non-small-cell lung cancer cell lines H460 and A549. Cisplatin-resistant cells were obtained after a single treatment with the drug. CSCs were isolated by culture in defined media, under nonadherent conditions...
October 2014: Cancer Medicine
https://www.readbyqxmd.com/read/24670268/human-adult-bone-marrow-derived-stem-cells-decrease-severity-of-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-in-sheep
#15
Mauricio Rojas, Nayra Cárdenes, Ergin Kocyildirim, John R Tedrow, Eder Cáceres, Robert Deans, Anthony Ting, Christian Bermúdez
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventions that have proven beneficial are protective ventilation strategies and fluid conservation approaches. New therapies are needed to address this common clinical problem. Others and we have previously shown the beneficial effect of infusion of exogenous adult stem cells in different pre-clinical models of ARDS...
2014: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/24244156/involvement-of-the-cellular-phosphatase-dusp1-in-vaccinia-virus-infection
#16
Ana Cáceres, Beatriz Perdiguero, Carmen E Gómez, Maria Victoria Cepeda, Carme Caelles, Carlos Oscar Sorzano, Mariano Esteban
Poxviruses encode a large variety of proteins that mimic, block or enhance host cell signaling pathways on their own benefit. It has been reported that mitogen-activated protein kinases (MAPKs) are specifically upregulated during vaccinia virus (VACV) infection. Here, we have evaluated the role of the MAPK negative regulator dual specificity phosphatase 1 (DUSP1) in the infection of VACV. We demonstrated that DUSP1 expression is enhanced upon infection with the replicative WR virus and with the attenuated VACV viruses MVA and NYVAC...
2013: PLoS Pathogens
https://www.readbyqxmd.com/read/24102516/synthesis-and-chemical-and-biological-comparison-of-nitroxyl-and-nitric-oxide-releasing-diazeniumdiolate-based-aspirin-derivatives
#17
COMPARATIVE STUDY
Debashree Basudhar, Gaurav Bharadwaj, Robert Y Cheng, Sarthak Jain, Sa Shi, Julie L Heinecke, Ryan J Holland, Lisa A Ridnour, Viviane M Caceres, Regina C Spadari-Bratfisch, Nazareno Paolocci, Carlos A Velázquez-Martínez, David A Wink, Katrina M Miranda
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity, but they may increase the risk of myocardial infarction with chronic use. The fact that nitroxyl (HNO) reduces platelet aggregation, preconditions against myocardial infarction, and enhances contractility led us to synthesize a diazeniumdiolate-based HNO-releasing aspirin and to compare it to an NO-releasing analogue...
October 24, 2013: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/23428562/mesenchymal-stem-cells-a-promising-therapy-for-the-acute-respiratory-distress-syndrome
#18
REVIEW
Nayra Cárdenes, Eder Cáceres, Militza Romagnoli, Mauricio Rojas
Acute respiratory distress syndrome (ARDS) is a pulmonary syndrome with growing prevalence and high mortality and morbidity that increase with age. There is no current therapy able to restore pulmonary function in ARDS patients. Preclinical models of ARDS have demonstrated that intratracheal or systemic administration of mesenchymal stem cells (MSCs) protects the lung against injury. The mechanisms responsible for the protective effects are multiple, including the secretion of multiple paracrine factors capable of modulating the immune response and restoring epithelial and endothelial integrity...
2013: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/22737828/hispanic-with-a-primary-pulmonary-angiosarcoma-case-report-and-literature-review
#19
REVIEW
Diógenes Alayón-Laguer, Ilean Joan Padua, Norma Arroyo, William Cáceres, Daniel Conde-Sterling
We report the case of a male Hispanic patient with a left lower lung mass that invaded the left pulmonary vein associated with left intra atrial tumor mass extension. Pathology diagnosis was consistent with an Angiosarcoma that upon correlation with pattern of growth and dissemination, was considered to be of lung origin. Angiosarcoma is a malignant tumor derived from vascular endothelial cell and accounts for 1% of adult's soft tissue sarcomas. Pulmonary Angiosarcomas are usuaIly secondary tumors with less than twenty cases described in the medical literature...
October 2011: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/22613334/-efficacy-of-gemcitabine-and-vinorelbine-in-first-line-treatment-with-advanced-non-small-cell-lung-cancer-a-multicentre-retrospective-study
#20
MULTICENTER STUDY
Yongfeng Yu, Li Zhang, Zhisheng Ren, Jiujun Zhao, Zhongrui Li, Shun Lu
BACKGROUND AND OBJECTIVE: Chemotherapy has become the mainstay of first-line therapy. Non-platinum containing drugs are characterized by favorable toxicity profiles and is better tolerated than platinum-based regimens. The aim of this study is to detect the efficacy and toxicity of gemcitabine and vinorelbine (GN) in advanced non-small cell lung cancer (NSCLC) first-line treatment in China. METHODS: We retrospectively reviewed 67 NSCLC patients treated with this agent at five Hospital in China from Jan 2004 to Jun 2010...
May 2012: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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