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JOURNAL ARTICLE
Matias Cardenas, Brittany Seibert, Brianna Cowan, Ana Luiza S Fraiha, Silvia Carnaccini, L Claire Gay, Flavio Cargnin Faccin, C Joaquin Caceres, Tavis K Anderson, Amy L Vincent Baker, Daniel R Perez, Daniela S Rajao
Influenza A virus (FLUAV) infects a wide range of hosts and human-to-swine spillover events are frequently reported. However, only a few of these human viruses have become established in pigs and the host barriers and molecular mechanisms driving adaptation to the swine host remain poorly understood. We previously found that infection of pigs with a 2:6 reassortant virus (hVIC/11) containing the hemagglutinin (HA) and neuraminidase (NA) gene segments from the human strain A/Victoria/361/2011 (H3N2) and internal gene segments of an endemic swine strain (sOH/04) resulted in a fixed amino acid substitution in the HA (A138S, mature H3 HA numbering)...
February 20, 2024: PLoS Pathogens
#2
REVIEW
Jose Diego Caceres, Anand Venkata
PURPOSE OF REVIEW: Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome characterized by upper lobe emphysema with lower lobe fibrosis. We aim to bring some clarity about its definition, nature, pathophysiology, and clinical implications. RECENT FINDINGS: Although multiple genetic and molecular pathways have been implicated in the development of CPFE, smoking is considered the most prevalent risk factor. CPFE is most prevalent in middle-aged men with more than 40 pack-years of smoking and can be seen in about 8% of all chronic obstructive pulmonary disease (COPD) patients...
March 1, 2024: Current Opinion in Pulmonary Medicine
#3
Herman Li, Linh Le, Mariah Marrero, Jennifer David-Bercholz, Anabel Isabel Caceres, Claire Lim, Wesley Chiang, Ania Majewska, Niccolo Terrando, Harris Gelbard
BACKGROUND: Links between acute lung injury (ALI), infectious disease, and neurological outcomes have been frequently discussed over the past few years, especially due to the COVID-19 pandemic. Yet, much of the cross-communication between organs, particularly the lung and the brain, has been understudied. Here, we have focused on the role of neutrophils in driving changes to the brain endothelium with ensuing microglial activation and neuronal loss in a model of ALI. METHODS: We have applied a three-dose paradigm of 10μg/40μl intranasal lipopolysaccharide (LPS) to induce neutrophilia accompanied by proteinaceous exudate in bronchoalveolar lavage fluid (BALF) in adult C57BL/6 mice...
October 23, 2023: Research Square
#4
Herman Li, Linh Le, Mariah Marrero, Jennifer David-Bercholz, Ana I Caceres, Claire Lim, Wesley Chiang, Ania K Majewska, Niccolò Terrando, Harris A Gelbard
BACKGROUND: Links between acute lung injury (ALI), infectious disease, and neurological outcomes have been frequently discussed over the past few years, especially due to the COVID-19 pandemic. Yet, much of the cross-communication between organs, particularly the lung and the brain, has been understudied. Here, we have focused on the role of neutrophils in driving changes to the brain endothelium with ensuing microglial activation and neuronal loss in a model of ALI. METHODS: We have applied a three-dose paradigm of 10µg/40µl intranasal lipopolysaccharide (LPS) to induce neutrophilia accompanied by proteinaceous exudate in bronchoalveolar lavage fluid (BALF) in adult C57BL/6 mice...
October 17, 2023: bioRxiv
#5
JOURNAL ARTICLE
miR-124 as a Liquid Biopsy Prognostic Biomarker in Small Extracellular Vesicles from NSCLC Patients.
Darío Sanchez-Cabrero, Álvaro Garcia-Guede, Miranda Burdiel, Olga Pernía, Julián Colmenarejo-Fernandez, Laura Gutierrez, Oliver Higuera, Isabel Esteban Rodriguez, Rocío Rosas-Alonso, Carlos Rodriguez-Antolín, Itsaso Losantos-García, Olga Vera, Javier De Castro-Carpeño, Inmaculada Ibanez de Caceres
Despite advances in non-small cell lung cancer (NSCLC) research, this is still the most common cancer type that has been diagnosed up to date. microRNAs have emerged as useful clinical biomarkers in both tissue and liquid biopsy. However, there are no reliable predictive biomarkers for clinical use. We evaluated the preclinical use of seven candidate miRNAs previously identified by our group. We collected a total of 120 prospective samples from 88 NSCLC patients. miRNA levels were analyzed via qRT-PCR from tissue and blood samples...
July 14, 2023: International Journal of Molecular Sciences
#6
JOURNAL ARTICLE
Inmaculada Ruiz-Cáceres, Teresa Hermida Romero, Isabel Guerra Merino, Joseba Portu Zapirain, Belén Pérez-Mies, Matilde Sánchez-Conde, Marina Alonso Riaño, Rafael Rubio, Jose Fortés Alen, Ánxela Vidal González, Clara Salas Antón, Elena Múñez, Rafael Sánchez Sánchez, Diana Corona-Mata, Iban Aldecoa Ansorregui, José M Miró, Raquel Beloqui Pérez de Obanos, Carlos Ibero, Javier Gómez-Román, M Carmen Fariñas, Teresa Tabuyo Bello, Enrique de Alava, José Miguel Cisneros, Xavier Matías-Guiu, Antonio Rivero
INTRODUCTION: Whole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. METHODS: This was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form...
2023: Frontiers in Medicine
#7
JOURNAL ARTICLE
Laura Carrasco Hernández, Rosa Mª Girón Moreno, Mari Nieves Balaguer Cartagena, Adrián Peláez, Amparo Sole, Antonio Álvarez Fernández, Almudena Felipe Montiel, Casilda Olveira, Gabriel Olveira, Ainhoa Gómez Bonilla, Beatriz Gómez Crespo, Marta García Clemente, Marta Solís García, Joana Quaresma Vázquez, Enrique Blitz Castro, Jesús Rodríguez González, Andrea Expósito Marrero, Laila Diab-Cáceres, Cristina Ramos Hernández, Ester Zamarrón de Lucas, Concha Prados Sanchez, Marina Blanco Aparicio, Alejandro López Neyra, Verónica Sanz Santiago, Carmen Luna Paredes, Isabel Delgado Pecellín, Óscar Asensio de la Cruz, Esther Quintana Gallego
INTRODUCTION: Elexacaftor/tezacaftor/ivacaftor (ETI) was used through the early access programme in Spain from December 2019 in cystic fibrosis (CF) patients with homozygous or heterozygous F508del mutation with advanced lung disease. METHODOLOGY: Multicentre, ambispective, observational, study in which 114 patients in follow-up in 16 national CF units were recruited. Clinical data, functional tests, nutritional parameters, quality of life questionnaires, microbiological isolates, number of exacerbations, antibiotic treatments and side effects were collected...
June 9, 2023: Archivos de Bronconeumología
#8
JOURNAL ARTICLE
Javier Guijarro-Eguinoa, Sara Arjona-Hernandez, Stefan Stewart, Olga Pernia, Pedro Arias, Itsaso Losantos-García, Tania Rubio, Miranda Burdiel, Carlos Rodriguez-Antolin, Patricia Cruz-Castellanos, Oliver Higuera, Alberto M Borobia, Sonia Rodriguez-Novoa, Javier de Castro-Carpeño, Inmaculada Ibanez de Caceres, Rocio Rosas-Alonso
Platin-based chemotherapy is the standard treatment for patients with non-small cell lung cancer (NSCLC). However, resistance to this therapy is a major obstacle in successful treatment. In this study, we aimed to investigate the impact of several pharmacogenetic variants in patients with unresectable NSCLC treated with platin-based chemotherapy. Our results showed that DPYD variant carriers had significantly shorter progression-free survival and overall survival compared to DPYD wild-type patients, whereas DPD deficiency was not associated with a higher incidence of high-grade toxicity...
June 7, 2023: International Journal of Molecular Sciences
#9
Emily A Wheeler, Patricia M Lenhart-Pendergrass, Noel M Rysavy, Katie Poch, Silvia Caceres, Kara M Calhoun, Karina Serban, Jerry A Nick, Kenneth C Malcolm
Mycobacterium abscessus is a nontuberculous mycobacterium emerging as a significant pathogen for individuals with chronic lung disease, including cystic fibrosis and chronic obstructive pulmonary disease. Current therapeutics have poor efficacy. New strategies of bacterial control based on host defenses are appealing, but anti-mycobacterial immune mechanisms are poorly understood and are complicated by the appearance of smooth and rough morphotypes with distinct host responses. We explored the role of the complement system in the clearance of M...
May 16, 2023: bioRxiv
#10
JOURNAL ARTICLE
Lalit K Gautam, Noa C Harriott, Adrian M Caceres, Amy L Ryan
The airway epithelium provides a physical and biochemical barrier playing a key role in protecting the lung from infiltration of pathogens and irritants and is, therefore, crucial in maintaining tissue homeostasis and regulating innate immunity. Due to continual inspiration and expiration of air during breathing, the epithelium is exposed to a plethora of environmental insults. When severe or persistent, these insults lead to inflammation and infection. The effectiveness of the epithelium as a barrier is reliant upon its capacity for mucociliary clearance, immune surveillance, and regeneration upon injury...
2023: Advances in Experimental Medicine and Biology
#11
Susanta Pahari, Eusondia Arnett, Jan Simper, Abul Azad, Israel Guerrero-Arguero, Chengjin Ye, Hao Zhang, Hong Cai, Yufeng Wang, Zhao Lai, Natalie Jarvis, Miranda Lumbreras, Diego Jose Maselli-Caceres, Jay Peters, Jordi B Torrelles, Luis Martinez-Sobrido, Larry S Schlesinger
UNLABELLED: Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAM) to pulmonary diseases remains poorly understood due to difficulty in accessing them from human donors and their rapid phenotypic change during in vitro culture. Thus, there remains an unmet need for cost-effective methods for generating and/or differentiating primary cells into a HAM phenotype, particularly important for translational and clinical studies...
April 6, 2023: bioRxiv
#12
JOURNAL ARTICLE
Jane E Gross, Charlotte C Teneback, Julie G Sweet, Silvia M Caceres, Katie R Poch, Nabeeh A Hasan, Fan Jia, L Elaine Epperson, Ettie M Lipner, Charmie K Vang, Jennifer R Honda, Matthew J Strand, Vinicius Calado Nogueira de Moura, Charles L Daley, Michael Strong, Rebecca M Davidson, Jerry A Nick
RATIONALE: Outbreaks of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) have been reported at CF Centers with conflicting conclusions. Occurrence of NTM at the University of Vermont Medical Center Adult CF Program was investigated. OBJECTIVES: Utilize the Healthcare-associated Links in Transmission of NTM (HALT NTM) toolkit to investigate healthcare-associated transmission and/or acquisition of NTM among pwCF having genetically similar NTM isolates...
January 19, 2023: Annals of the American Thoracic Society
#13
JOURNAL ARTICLE
Patricia M Lenhart-Pendergrass, Kenneth C Malcolm, Emily Wheeler, Noel M Rysavy, Katie Poch, Silvia Caceres, Kara M Calhoun, Stacey L Martiniano, Jerry A Nick
Nontuberculous mycobacteria (NTM), including Mycobacterium avium, are clinically important pathogens in cystic fibrosis (CF). The innate immune response to M. avium remains incompletely understood. We evaluated the role of complement opsonization in neutrophil-mediated killing of M. avium. Killing assays were performed using neutrophils from healthy donors (HDs) and persons with CF (pwCF). Clinical isolates of M. avium were opsonized with plasma from HDs or pwCF, which was intact or heat-treated to inactivate complement...
January 18, 2023: Microbiology Spectrum
#14
REVIEW
Jose Diego Caceres, Anand N Venkata
PURPOSE OF REVIEW: Exposure to asbestos can cause both benign and malignant, pulmonary and pleural diseases. In the current era of low asbestos exposure, it is critical to be aware of complications from asbestos exposure; as they often arise after decades of exposure, asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions and malignant pleural mesothelioma. RECENT FINDINGS: Multiple recent studies are featured in this review, including a study evaluating imaging characteristics of asbestos with other fibrotic lung diseases, a study that quantified pleural plaques on computed tomography imaging and its impact on pulmonary function, a study that examined the risk of lung cancer with pleural plaques among two large cohorts and a review of nonasbestos causes of malignant mesothelioma...
March 1, 2023: Current Opinion in Pulmonary Medicine
#15
JOURNAL ARTICLE
Francesca Favaro, Fedra Luciano-Mateo, Joaquim Moreno-Caceres, Miguel Hernández-Madrigal, Demi Both, Chiara Montironi, Franziska Püschel, Ernest Nadal, Eric Eldering, Cristina Muñoz-Pinedo
Interleukin-8 (IL-8/CXCL8) is a pro-angiogenic and pro-inflammatory chemokine that plays a role in cancer development. Non-small cell lung carcinoma (NSCLC) produces high amounts of IL-8, which is associated with poor prognosis and resistance to chemo-radio and immunotherapy. However, the signaling pathways that lead to IL-8 production in NSCLC are unresolved. Here, we show that expression and release of IL-8 are regulated autonomously by TRAIL death receptors in several squamous and adenocarcinoma NSCLC cell lines...
December 15, 2022: Cell Death & Disease
#16
JOURNAL ARTICLE
Brittany Seibert, C Joaquín Cáceres, Silvia Carnaccini, Stivalis Cardenas-Garcia, L Claire Gay, Lucia Ortiz, Ginger Geiger, Daniela S Rajao, Elizabeth Ottesen, Daniel R Perez
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS2) affected the geriatric population. Among research models, Golden Syrian hamsters (GSH) are one of the most representative to study SARS2 pathogenesis and host responses. However, animal studies that recapitulate the effects of SARS2 in the human geriatric population are lacking. To address this gap, we inoculated 14 months old GSH with a prototypic ancestral strain of SARS2 and studied the effects on virus pathogenesis, virus shedding, and respiratory and gastrointestinal microbiome changes...
October 2022: PLoS Pathogens
#17
REVIEW
Yannick Van Herck, Annelies Feyaerts, Shabbir Alibhai, Demetris Papamichael, Lore Decoster, Yentl Lambrechts, Michael Pinchuk, Oliver Bechter, Jaime Herrera-Caceres, Frédéric Bibeau, Christine Desmedt, Sigrid Hatse, Hans Wildiers
Roughly 50% of cancer cases occur in people aged 65 years or older. Older people are often diagnosed at a later stage and might receive less (intensive) treatment, which might affect the outcome. In addition, an older age might be associated with biological differences in tumour and microenvironment behaviour, a domain that has been poorly studied so far. In this narrative Review of published literature, we explored the reported differences in tumour biology according to age in five major cancer types: breast, colorectal, prostate, lung, and melanoma...
October 2021: The Lancet. Healthy longevity
#18
JOURNAL ARTICLE
Wen Chen, Fengjie Guo, Zhipeng Ren, Linghui Wang, Tinghui Li, Xiaobin Hou
Malignant pleural effusion is one of the most common complications of advanced lung cancer and there is no effective clinical treatment at present. Here, we constructed an aptamer-siRNA chimeras/PEI/PEG/gold nanoparticle (AuNP)/collagen membrane that can progressively activate T cells by layer by layer assembly. Electron microscope showed this collagen membrane could be divided into 10 layers with a total thickness of 50-80μm, and AuNPs could be observed. Aptamer-siRNA chimeras could bind specifically to OX40+ cells and silencing programmed death receptor-1 (PD-1) gene...
2022: Frontiers in Bioengineering and Biotechnology
#19
JOURNAL ARTICLE
Kenneth C Malcolm, Emily A Wheeler, Kara Calhoun, Patricia M Lenhart-Pendergrass, Noel Rysavy, Katie R Poch, Silvia M Caceres, Milene T Saavedra, Jerry A Nick
Nontuberculous mycobacteria (NTM) infections are increasingly prevalent in chronic lung diseases, including cystic fibrosis (CF). Mycobacterium abscessus is of particular concern due to relatively greater virulence and intrinsic antimicrobial resistance. Airway culture identification, the standard method for detecting pulmonary infection, is hindered by low sensitivity, long culture times, and reliance on sputum production or lavage. A culture-independent test for detecting NTM infection could complement, or replace, sputum culture, which is becoming more difficult to obtain with reduced sputum production by people with CF (pwCF) on highly effective modulator therapy...
July 6, 2022: Microbiology Spectrum
#20
JOURNAL ARTICLE
Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Malte C Rühlemann, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Eike M Wacker, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alba-Estela Garcia-Fernandez, Albert Blanco-Grau, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Caballero-Garralda, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anja Tanck, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Anna Peschuck, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Axel Schmidt, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph D Spinner, Christoph Gassner, Christoph Lange, Cinzia Hu, Cinzia Paccapelo, Clara Lehmann, Claudio Angelini, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Cea, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eduardo Muñiz-Diaz, Elena Azzolini, Elena Sandoval, Eleonora Binatti, Elio Scarpini, Elisa T Helbig, Elisabetta Casalone, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique J Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana-Arri, Fátima Aziz, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco J Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Georg Hemmrich-Stanisak, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giulia Cardamone, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Giuseppe Matullo, Guido Baselli, Hayato Kurihara, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar Rojas, Iván Galván-Femenia, Jan Cato Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kässens, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Javier Martín, Jeanette Erdmann, Jesus M Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan M Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline I Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena J Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Manolis Kogevinas, Mar Riveiro-Barciela, Marc M Berger, Marco Schaefer, Mari E K Niemi, María A Gutiérrez-Stampa, Maria Carrabba, Maria E Figuera Basso, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria J G T Vehreschild, Maria Manunta, Marialbert Acosta-Herrera, Mariella D'Angiò, Marina Baldini, Marina Cazzaniga, Marit M Grimsrud, Markus Cornberg, Markus M Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D'Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael J Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Michele Ciccarelli, Miguel Rodríguez-Gandía, Monica Bocciolone, Monica Miozzo, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Braun, Nicole Ludwig, Nikolaus Marx, Nilda Martínez, Oliver A Cornely, Oliver Witzke, Orazio Palmieri, Paola Faverio, Paoletta Preatoni, Paolo Bonfanti, Paolo Omodei, Paolo Tentorio, Pedro Castro, Pedro M Rodrigues, Pedro Pablo España, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raúl Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocío Gallego-Durán, Rosa Nieto, Rossana Carpani, Rubén Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bombace, Sara Marsal, Sara Pigazzini, Sebastian Klein, Serena Pelusi, Sibylle Wilfling, Silvano Bosari, Sonja Volland, Søren Brunak, Soumya Raychaudhuri, Stefan Schreiber, Stefanie Heilmann-Heimbach, Stefano Aliberti, Stephan Ripke, Susanne Dudman, Tanja Wesse, Tenghao Zheng, Thomas Bahmer, Thomas Eggermann, Thomas Illig, Thorsten Brenner, Tomas Pumarola, Torsten Feldt, Trine Folseraas, Trinidad Gonzalez Cejudo, Ulf Landmesser, Ulrike Protzer, Ute Hehr, Valeria Rimoldi, Valter Monzani, Vegard Skogen, Verena Keitel, Verena Kopfnagel, Vicente Friaza, Victor Andrade, Victor Moreno, Wolfgang Albrecht, Wolfgang Peter, Wolfgang Poller, Xavier Farre, Xiaoli Yi, Xiaomin Wang, Yascha Khodamoradi, Zehra Karadeniz, Anna Latiano, Siegfried Goerg, Petra Bacher, Philipp Koehler, Florian Tran, Heinz Zoller, Eva C Schulte, Bettina Heidecker, Kerstin U Ludwig, Javier Fernández, Manuel Romero-Gómez, Agustín Albillos, Pietro Invernizzi, Maria Buti, Stefano Duga, Luis Bujanda, Johannes R Hov, Tobias L Lenz, Rosanna Asselta, Rafael Cid, Luca Valenti, Tom H Karlsen, Mario Cáceres, Andre Franke
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome...
July 15, 2022: Human Molecular Genetics
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