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https://www.readbyqxmd.com/read/27877916/study-of-local-intracellular-signals-regulating-axonal-morphogenesis-using-a-microfluidic-device
#1
Daiki Uryu, Tomohiro Tamaru, Azusa Suzuki, Rie Sakai, Yoshiyuki Konishi
The establishment and maintenance of axonal patterning is crucial for neuronal function. To identify the molecular systems that operate locally to control axonal structure, it is important to manipulate molecular functions in restricted subcellular areas for a long period of time. Microfluidic devices can be powerful tools for such purposes. In this study, we demonstrate the application of a microfluidic device to clarify the function of local Ca(2+) signals in axons. Membrane depolarization significantly induced axonal branch-extension in cultured cerebellar granule neurons (CGNs)...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27753872/ish-aha-1-a-case-of-refractory-hypertension-controlled-by-repeated-renal-denervation-and-celiac-plexus-block-a-case-of-refractory-sympathetic-overload
#2
Chan Joo Lee, Yeongmin Woo, Byeong-Keuk Kim, Kyung Bong Yoon, Hae-Young Lee, Sungha Park
A 30-year-old woman was referred to our hospital due to high blood pressure, dizziness, headache and blurred vision. She had past history of preeclampsia and gestational hypertension 4 years ago but she had not taken antihypertensive medication in spite of remained hypertension after delivery. She was hospitalized for fever due to urinary tract infection and severe hypertension which was above 210/140 mmHg. Despite maximal medical treatment with telmisartan 80 mg, nifedipine 120 mg, carvedilol 50 mg, doxazocin 8 mg, chlorthalidone 50 mg, spironolactone 50 mg#2, isosorbide dinitrate 80 mg and intermittent intravenous administration of nicardipine and labetalol, her systolic blood pressure remained above 160 mmHg and repeatedly measured above 200 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749585/a-case-report-of-the-beneficial-effects-of-botulinum-toxin-type-a-on-raynaud-phenomenon-in-a-patient-with-lung-cancer
#3
Lu Wang, Qi-Song Lei, Yu-Ying Liu, Guan-Jie Song, Chun-Ling Song
OBJECTIVE: Raynaud phenomenon is a vasospastic disorder affecting the hands and feet, and the efficacies of traditional treatments, such as pharmacological therapies and sympathectomy, are not uniform. Patients with paraneoplastic Raynaud phenomenon do not benefit from the traditional treatments. The use of botulinum toxin type A (BTX-A) for Raynaud phenomenon has been reported for several years; however, there are few reports regarding botulinum toxin type A in the treatment of paraneoplastic Raynaud phenomenon...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27643109/ish-aha-1-a-case-of-refractory-hypertension-controlled-by-repeated-renal-denervation-and-celiac-plexus-block-a-case-of-refractory-sympathetic-overload
#4
Chan Joo Lee, Yeongmin Woo, Byeong-Keuk Kim, Kyung Bong Yoon, Hae-Young Lee, Sungha Park
A 30-year-old woman was referred to our hospital due to high blood pressure, dizziness, headache and blurred vision. She had past history of preeclampsia and gestational hypertension 4 years ago but she had not taken antihypertensive medication in spite of remained hypertension after delivery. She was hospitalized for fever due to urinary tract infection and severe hypertension which was above 210/140 mmHg. Despite maximal medical treatment with telmisartan 80 mg, nifedipine 120 mg, carvedilol 50 mg, doxazocin 8 mg, chlorthalidone 50 mg, spironolactone 50 mg#2, isosorbide dinitrate 80 mg and intermittent intravenous administration of nicardipine and labetalol, her systolic blood pressure remained above 160 mmHg and repeatedly measured above 200 mmHg...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27636540/topical-vasodilators-in-microsurgery-what-is-the-evidence
#5
Jacob Rinkinen, Eric G Halvorson
Background Topical vasodilators are frequently used during free tissue transfer to prevent and treat vasospasm and microvascular thrombosis. A variety of agents have been studied and are available, yet most microsurgeons select an agent based on anecdotal evidence or personal training. Our aim was to review the literature on topical vasodilators so microsurgeons can make more informed decisions about which agent to use. Methods A systemic review of the literature was performed on PubMed, EMBASE, and Google Scholar using keywords "topical vasodilator," "antispasmodic," "vasospasm," "free flaps," and "microsurgery...
September 16, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27567564/drug-delivery-to-the-human-and-mouse-uterus-using-immunoliposomes-targeted-to-the-oxytocin-receptor
#6
Jonathan W Paul, Susan Hua, Marina Ilicic, Jorge M Tolosa, Trent Butler, Sarah Robertson, Roger Smith
BACKGROUND: The ability to provide safe and effective pharmacotherapy during obstetric complications, such as preterm labor or postpartum hemorrhage, is hampered by the systemic toxicity of therapeutic agents leading to adverse side effects in the mother and fetus. Development of novel strategies to target tocolytic and uterotonic agents specifically to uterine myocytes would improve therapeutic efficacy while minimizing the risk of side effects. Ligand-targeted liposomes have emerged as a reliable and versatile platform for targeted drug delivery to specific cell types, tissues or organs...
August 24, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27540200/an-audit-of-whether-prescribed-doses-are-measurable-on-the-graduations-of-one-oral-syringe
#7
Jigna Balsara, Penny Fletcher
AIM: In paediatrics drugs are prescribed as mg/kg doses to facilitate accurate dosing. Anecdotally, some drugs are prescribed in such a way that the volume to be given is difficult to measure which may lead to inaccuracies and potential for error. Locally, errors have been reported where there has been a misunderstanding of the required dose, especially when decimal points are involved. This audit aimed to evaluate doses prescribed for in-patient children and evaluate whether they can be measured using the printed markings of one oral syringe...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27253186/clinical-case-report-a-rare-cause-of-acute-kidney-failure-tissue-is-the-issue
#8
W A Heggermont, G Verhoef, P Evenepoel, B Sprangers, E Lerut, T Tousseyn, K Claes
A patient was admitted to the medical emergency department by his family physician. His complaints were weakness and fatigue for more than one week. Four days before admission, he went to his general practitioner for these complaints and also for painful elbows. His physician prescribed diclofenac and esomeprazole. Upon presentation, he had high systolic/diastolic blood pressure (>180/>90 mm Hg, measured repeatedly), and otherwise normal parameters. He had gained 6.5 kg in body weight. Clinical examination was normal, except for very mild bilateral malleolar edema...
May 17, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27037709/tailored-therapy-for-different-presentations-of-chronic-pain-after-stapled-hemorrhoidopexy
#9
C R Asteria, J Robert-Yap, G Zufferey, F Colpani, A Pascariello, G Lucchini, B Roche
BACKGROUND: As stapled hemorrhoidopexy (SH) becomes more widely used, we see more patients with chronic postoperative anal pain after this surgery. Its presentation is variable and difficult to treat. The aim of our study was to investigate the impact of chronic anal pain after SH and whether tailored therapy was likely to achieve a favorable outcome. METHODS: We retrospectively analyzed 31 consecutive patients with chronic anal pain who had undergone SH in other hospitals and were referred to our institutions...
May 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27018759/hemolysed-blood-elicits-calcium-antagonist-and-high-co2-reversible-constrictions-via-elevation-of-ca2-in-isolated-cerebral-arteries
#10
Peter Cseplo, Zoltán Vámos, Orsolya Torok, Ivan Ivic, Attila Toth, Andras Buki, Akos Koller
During acute subarachnoid hemorrhage blood is hemolysed, which is followed by a significant cerebrovascular spasm resulting in serious clinical condition. Interestingly, however the direct vasomotor effect of perivascular hemolysed blood (HB) has not yet been characterized preventing the assessment of contribution of vasoconstrictor mechanisms deriving from brain tissue and/or blood and development of possible treatments. We hypothesized that perivascular HB reduces the diameter of the cerebral arteries (BA: basilar artery; MCA: middle cerebral artery) via elevating vascular tissue [Ca2+]i level...
March 28, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26990886/calcium-channels-in-chicken-sperm-regulate-motility-and-the-acrosome-reaction
#11
Thi Mong Diep Nguyen, Anne Duittoz, Christophe Praud, Yves Combarnous, Elisabeth Blesbois
Intracellular cytoplasmic calcium ([Ca(2+) ]i ) has an important regulatory role in gamete functions. However, the biochemical components involved in Ca(2+) transport are still unknown in birds, an animal class that has lost functional sperm-specific CatSper channels. Here, we provide evidence for the presence and expression of various Ca(2+) channels in chicken sperm, including high voltage-activated channels (L and R types), the store-operated Ca(2+) channel (SOC) component Orai1, the transient receptor potential channel (TRPC1) and inositol-1,4,5-trisphosphate receptors (IP3 R1)...
May 2016: FEBS Journal
https://www.readbyqxmd.com/read/26797505/diverse-firing-properties-and-a%C3%AE-a%C3%AE-and-c-afferent-inputs-of-small-local-circuit-neurons-in-spinal-lamina-i
#12
Elisabete C Fernandes, Liliana L Luz, Oleh Mytakhir, Nikolai V Lukoyanov, Peter Szucs, Boris V Safronov
Spinal lamina I is a key element of the pain processing system, which integrates primary afferent input and relays it to supraspinal areas. More than 90% of neurons in this layer are local circuit neurons, whose role in the signal processing is poorly understood. We performed whole-cell recordings in a spinal cord preparation with attached dorsal roots to examine morphological features and physiological properties of small local circuit neurons (n = 47) in lamina I. Cells successfully filled with biocytin (n = 17) had fusiform (n = 10), flattened (n = 4), and multipolar (n = 3) somatodendritic morphology; their axons branched extensively and terminated in laminae I-III...
February 2016: Pain
https://www.readbyqxmd.com/read/26689736/calmidazolium-evokes-high-calcium-fluctuations-in-plasmodium-falciparum
#13
Alexandre Budu, Mayrim M Gomes, Pollyana M Melo, Sarah El Chamy Maluf, Piero Bagnaresi, Mauro F Azevedo, Adriana K Carmona, Marcos L Gazarini
Calcium and calmodulin (CaM) are important players in eukaryote cell signaling. In the present study, by using a knockin approach, we demonstrated the expression and localization of CaM in all erythrocytic stages of Plasmodium falciparum. Under extracellular Ca(2+)-free conditions, calmidazolium (CZ), a potent CaM inhibitor, promoted a transient cytosolic calcium ([Ca(2+)]cyt) increase in isolated trophozoites, indicating that CZ mobilizes intracellular sources of calcium. In the same extracellular Ca(2+)-free conditions, the [Ca(2+)]cyt rise elicited by CZ treatment was ~3...
March 2016: Cellular Signalling
https://www.readbyqxmd.com/read/26606583/-digital-necrosis-after-local-anaesthesia-with-epinephrine
#14
Kor H Hutting, Juliaan R M van Rappard, Alwin Prins, Anneke B Knepper, Chantal M Mouës-Vink
BACKGROUND: To date, there is a lack of consensus concerning the application of local anaesthetics with epinephrine in fingers, due to the alleged risk of ischaemic complications. CASE DESCRIPTION: We present the case of a 70-year old woman, with a medical history of diabetes mellitus and an ischemic cerebral infarct, who underwent operative trigger finger release under local anaesthetics with 1% lidocaine-epinephrine (1:100,000) solution. A few hours later, she developed persisting numbness and ischemic symptoms of the digits...
2015: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/26483696/localized-nuclear-and-perinuclear-ca-2-signals-in-intact-mouse-skeletal-muscle-fibers
#15
Tihomir Georgiev, Mikhail Svirin, Enrique Jaimovich, Rainer H A Fink
Nuclear Ca(2+) is important for the regulation of several nuclear processes such as gene expression. Localized Ca(2+) signals (LCSs) in skeletal muscle fibers of mice have been mainly studied as Ca(2+) release events from the sarcoplasmic reticulum. Their location with regard to cell nuclei has not been investigated. Our study is based on the hypothesis that LCSs associated with nuclei are present in skeletal muscle fibers of adult mice. Therefore, we carried out experiments addressing this question and we found novel Ca(2+) signals associated with nuclei of skeletal muscle fibers (with possibly attached satellite cells)...
2015: Frontiers in Physiology
https://www.readbyqxmd.com/read/26478127/hydrogen-peroxide-activates-store-operated-ca-2-entry-in-coronary-arteries
#16
Elvira Santiago, Belén Climent, Mercedes Muñoz, Albino García-Sacristán, Luis Rivera, Dolores Prieto
BACKGROUND AND PURPOSE: Abnormal Ca(2+) metabolism has been involved in the pathogenesis of vascular dysfunction associated with oxidative stress. Here, we have investigated the actions of H2 O2 on store-operated Ca(2+) (SOC) entry in coronary arteries and assessed whether it is impaired in arteries from a rat model of metabolic syndrome. EXPERIMENTAL APPROACH: Simultaneous measurements of intracellular Ca(2+) concentration and contractile responses were made in coronary arteries from Wistar and obese Zucker rats, mounted in microvascular myographs, and the effects of H2 O2 were assessed...
November 2015: British Journal of Pharmacology
https://www.readbyqxmd.com/read/26087697/the-novel-kv7-2-kv7-3-channel-opener-ica-069673-reveals-subtype-specific-functional-roles-in-guinea-pig-detrusor-smooth-muscle-excitability-and-contractility
#17
Aaron Provence, John Malysz, Georgi V Petkov
The physiologic roles of voltage-gated KV7 channel subtypes (KV7.1-KV7.5) in detrusor smooth muscle (DSM) are poorly understood. Here, we sought to elucidate the functional roles of KV7.2/KV7.3 channels in guinea pig DSM excitability and contractility using the novel KV7.2/KV7.3 channel activator ICA-069673 [N-(2-chloro-5-pyrimidinyl)-3,4-difluorobenzamide]. We employed a multilevel experimental approach using Western blot analysis, immunocytochemistry, isometric DSM tension recordings, fluorescence Ca(2+) imaging, and perforated whole-cell patch-clamp electrophysiology...
September 2015: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26027835/nifedipine-prevents-sodium-caprate-induced-barrier-dysfunction-in-human-epidermal-keratinocyte-cultures
#18
Yoshihiro Uchino, Junichi Matsumoto, Takuya Watanabe, Masato Hamabashiri, Takashi Tsuchiya, Ikuya Kimura, Atsushi Yamauchi, Yasufumi Kataoka
Tight junctions (TJs) of the epidermis play an important role in maintaining the epidermal barrier. TJ breakdown is associated with skin problems, such as wrinkles and transepidermal water loss (TEWL). Clinical studies have reported that topical nifedipine is effective in reducing the depth of wrinkles and improving TEWL. However, it remains unknown whether nifedipine influences the TJ function in the epidermis. In the present study, we investigated the effect of nifedipine on epidermal barrier dysfunction in normal human epidermal keratinocytes (NHEKs) treated with sodium caprate (C10), a TJ inhibitor...
2015: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/25909299/a-systematic-review-of-topical-vasodilators-for-the-treatment-of-intraoperative-vasospasm-in-reconstructive-microsurgery
#19
REVIEW
Christina R Vargas, Matthew L Iorio, Bernard T Lee
BACKGROUND: Intraoperative vasospasm during reconstructive microsurgery is common, often unpredictable, and potentially devastating with regard to flap survival. Current methods of pharmacologic management vary, and may be shifting as a result of changes in the availability of individual medications. This review aims to provide a concise examination of the published literature regarding use, efficacy, and adverse effects of the agents described for local management of vascular spasm during microsurgery...
August 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/25810601/recurrent-idiopathic-gingival-fibromatosis-with-generalized-aggressive-periodontitis-a-rare-case-report
#20
Ashwini Sudhakar Jadhav, Swati Pramodan Marathe
Gingival fibromatosis is an enlargement of the gingival tissue, which may be localized or generalized, characterized by hypertrophy and proliferation of the connective tissue, predominantly Type I collagen, with occasional presence of an increased number of cells, supposedly fibroblasts. Gingival fibromatosis occurs more commonly as a side- effect of systemic drugs, such as phenytoin, cyclosporine, nifedipine, or due to hereditary factors. However, in some cases, it is idiopathic. We report one such case in 30 -year- old - female who presented with a complaint of swelling of gums since 2 months...
January 2015: Journal of Indian Society of Periodontology
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