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Steroid receptor coactivator

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https://www.readbyqxmd.com/read/29786798/studies-on-steroid-receptor-coactivators-in-prostate-cancer
#1
Zoran Culig, Frédéric R Santer
High expression of several androgen receptor coactivators is frequently reported in prostate cancer. Coactivators such as p300/CBP are involved in modulation of androgen receptor activity by increasing the effects of androgenic hormones and enhancing agonistic activity of antiandrogens. Studies in the field of prostate cancer frequently examined the role of p300/CBP and SRC-1 (NCOA1). In addition to their effects on steroid receptor activity, coactivators may influence other cellular functions such as migration and invasion...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29786796/techniques-for-evaluation-of-ar-transcriptional-output-and-recruitment-to-dna
#2
Manqi Zhang, William C Krause, Irina U Agoulnik
Steroid receptors are ligand activated transcription factors whose promoter specificity is regulated by a broad set of coregulators and pioneer factors. Corepressors and coactivators determine receptors' recruitment to specific regulatory elements and ultimately their transcriptional output. Using androgen receptor (AR) and NCOR1 corepressor as examples, this chapter describes experimental approaches to evaluate recruitment of steroid receptors and their coregulators to DNA and to determine coregulator contribution to the transcriptional output of the receptor...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29766567/melatonin-attenuates-osteosarcoma-cell-invasion-by-suppression-of-c-c-motif-chemokine-ligand-24-through-inhibition-of-the-c-jun-n-terminal-kinase-pathway
#3
Ko-Hsiu Lu, Shih-Chi Su, Chiao-Wen Lin, Yi-Hsien Hsieh, Ya-Chiu Lin, Ming-Hsien Chien, Russel J Reiter, Shun-Fa Yang
Osteosarcoma, with its high metastatic potential, is the most prevalent malignant bone tumor in children and adolescents. Melatonin possesses multiple tumor-suppressing properties for a myriad of tumors, but little is known about the effects of melatonin on osteosarcoma metastasis. In this study, we demonstrated that melatonin elicited very low cytotoxicity and significantly inhibited cellular motility, migration, and invasion in human osteosarcoma U2OS and HOS cells. Moreover, using RNA sequencing technology, we revealed that melatonin repressed C-C motif chemokine ligand 24 (CCL24) gene expression in U2OS cells...
May 16, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29765014/steroid-receptor-coactivator-interacting-protein-sip-suppresses-myocardial-injury-caused-by-acute-pancreatitis
#4
Xin Chen, Bin Zhu
BACKGROUND Steroid receptor coactivator-interacting protein (SIP) inhibits the activation of nuclear factor-kappa B (NF-κB) by interacting with p65. The occurrence of acute pancreatitis (AP) is closely associated with pro-inflammatory response. The present study aimed to investigate the role of SIP on myocardial injury caused by AP. MATERIAL AND METHODS Rat pancreatic acinar tumor cell line AR42J cells were treated with caerulein to establish AP cell models. The levels of TNF-α, IL-6, cTnI, CK-MB, and LDH1 were detected by ELISA assay...
May 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29717026/steroid-receptor-coactivator-1-interacts-with-nf-%C3%AE%C2%BAb-to-increase-the-vegfc-level-in-human-thyroid-cancer
#5
Bo Gao, Lingji Guo, Donglin Luo, Yan Jiang, Jianjie Zhao, Chengyi Mao, Yan Xu
Thyroid cancer is the most common endocrine cancer, and has a high incidence of lymphatic metastasis. Vascular endothelial growth factor C (VEGFC) is essential for development of lymphatic vessels and lymphatic metastases during carcinogenesis. Steroid receptor coactivator-1 (SRC-1) interacts with nuclear receptors and transcription factors to promote tumor proliferation and metastasis. However, the correlation between SRC-1 and VEGFC levels in the lymphatic metastases of thyroid cancer remains unclear. We analyzed 20 paired specimens of thyroid cancer tissue and normal thyroid tissue and found increased levels of SRC-1 and VEGFC proteins in 13/20 and 15/20 thyroid cancer specimens, respectively, when compared with those levels in specimens of normal thyroid tissue...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29688519/a-possible-novel-mechanism-of-action-of-genistein-and-daidzein-for-activating-thyroid-hormone-receptor-tr-mediated-transcription
#6
Winda Ariyani, Toshiharu Iwasaki, Wataru Miyazaki, Yu Lu, Shigeki Takeda, Noriyuki Koibuchi
Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily that regulate their target genes for controlling organ development and functional maintenance. Soybean isoflavones, especially genistein and daidzein, modulate various hormone-mediated pathways. However, their effects on TRs have not yet been extensively studied. In this study, the effects of these isoflavones on TR action were evaluated using transient transfection-based reporter gene assays and molecular docking studies. Genistein and daidzein augmented T3-liganded TR-mediated transcription in a concentration-dependent manner...
April 23, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29615789/metabolic-enzyme-pfkfb4-activates-transcriptional-coactivator-src-3-to-drive-breast-cancer
#7
Subhamoy Dasgupta, Kimal Rajapakshe, Bokai Zhu, Bryan C Nikolai, Ping Yi, Nagireddy Putluri, Jong Min Choi, Sung Y Jung, Cristian Coarfa, Thomas F Westbrook, Xiang H-F Zhang, Charles E Foulds, Sophia Y Tsai, Ming-Jer Tsai, Bert W O'Malley
Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis1 . However, the mechanisms that control the interaction between metabolic reprogramming and transcriptional regulation remain unclear. Here we show that the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) regulates transcriptional reprogramming by activating the oncogenic steroid receptor coactivator-3 (SRC-3). We used a kinome-wide RNA interference-based screening method to identify potential kinases that modulate the intrinsic SRC-3 transcriptional response...
April 3, 2018: Nature
https://www.readbyqxmd.com/read/29581735/reverting-doxorubicin-resistance-in-colon-cancer-by-targeting-a-key-signaling-protein-steroid-receptor-coactivator
#8
Sang Xiong, Gong-Wei Xiao
Although there have been notable improvements in treatments against cancer, further research is required. In colon cancer, nearly all patients eventually experience drug resistance and stop responding to the approved drugs, making treatment difficult. Steroid receptor coactivator (SRC) is an oncogenic nuclear receptor coactivator that serves an important role in drug resistance. The present study generated a doxorubicin-resistant colon cancer cell line, in which the upregulation/activation of SRC was responsible for drug resistance, which in turn activated AKT...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29574604/evolution-of-melanoma-antigen-a11-magea11-during-primate-phylogeny
#9
Christopher S Willett, Elizabeth M Wilson
Melanoma antigen-A11 (MAGE-A11) is an X-linked and primate-specific steroid hormone receptor transcriptional coregulator and proto-oncogenic protein whose increased expression promotes the growth of prostate cancer. The MAGEA11 gene is expressed at low levels in normal human testis, ovary, and endometrium, and at highest levels in castration-resistant prostate cancer. Annotated genome predictions throughout the surviving primate lineage show that MAGEA11 acquired three 5' coding exons unique within the MAGEA subfamily during the evolution of New World monkeys (NWM), Old World monkeys (OWM), and apes...
March 24, 2018: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29567865/indomethacin-enhanced-brown-fat-activity
#10
Lei Hao, Jamie Kearns, Sheyenne Scott, Dayong Wu, Sean D Kodani, Christophe Morisseau, Bruce D Hammock, Xiaocun Sun, Shu Wang, Ling Zhao
Indomethacin, a non-steroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation, and activation in brown adipose tissue (BAT) and obesity are unknown. To address this issue, we treated mouse pre-brown cells with different doses of indomethacin, and delivered indomethacin to interscapular BAT (iBAT) of obese mice using implanted osmotic pumps. Indomethacin dose-dependently increased brown adipocyte differentiation, and upregulated both mRNA and protein expression of uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor (PPAR) gamma (γ) coactivator 1-alpha...
March 22, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29555554/timeless-is-a-novel-estrogen-receptor-co-activator-involved-in-multiple-signalling-pathways-in-mcf-7-cells
#11
Chantal Beatrice Magne Nde, Gloria Casas Gimeno, Maria Docanto, Kevin C Knower, Morag J Young, Jakob Buehn, Edris Sayed, Colin D Clyne
Activation of oestrogen receptor α (ERα) stimulates cell division and tumour growth by modulating the expression of ERα target genes. This activation involves the recruitment of specific proteins with activities that are still not fully understood. Timeless, the human homologue of the Drosophila gene involved in circadian rhythm, was previously shown to be a strong predictor of tamoxifen relapse, and is involved in genomic stability and cell cycle control. In this study, we investigated the interplay between Timeless and ERα, and showed that human Timeless is an ERα coactivator...
March 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29524638/steroid-receptor-coactivator-1-knockdown-decreases-synaptic-plasticity-and-impairs-spatial-memory-in-the-hippocampus-of-mice
#12
Chen Bian, Yan Huang, Haitao Zhu, Yangang Zhao, Jikai Zhao, Jiqiang Zhang
Steroids have been demonstrated to play profound roles in the regulation of hippocampal function by acting on their receptors, which need coactivators for their transcriptional activities. Previous studies have shown that steroid receptor coactivator-1 (SRC-1) is the predominant coactivator in the hippocampus, but its exact role and the underlying mechanisms remain unclear. In this study, we constructed SRC-1 RNA interference (RNAi) lentiviruses, injected them into the hippocampus of male mice, and then examined the changes in the expression of selected synaptic proteins, CA1 synapse density, postsynaptic density (PSD) thickness, and in vivo long-term potentiation (LTP)...
May 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29491215/cigarette-smoke-extract-disrupts-transcriptional-activities-mediated-by-thyroid-hormones-and-its-receptors
#13
Misa Hayashi, Kumi Futawaka, Midori Matsushita, Mayuko Hatai, Noriko Yoshikawa, Kazuki Nakamura, Tetsuya Tagami, Kenji Moriyama
Cigarette smoke contains over 4800 compounds, including at least 200 toxicants or endocrine disruptors. Currently, effects of cigarette smoke on thyroid hormone (TH) levels remains to be clarified. Here, we demonstrate that cigarette smoke extract (CSE) possesses thyroid hormone properties and acts synergistically as a partial agonist for thyroid hormone receptors (TRs) in the presence of TH. In transient gene expression experiments, CSE stimulated transcriptional activity with TH in a dose-dependent manner...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29452160/orchiectomy-and-letrozole-differentially-regulate-synaptic-plasticity-and-spatial-memory-in-a-manner-that-is-mediated-by-src-1-in-the-hippocampus-of-male-mice
#14
Jikai Zhao, Chen Bian, Mengying Liu, Yangang Zhao, Tao Sun, Fangzhou Xing, Jiqiang Zhang
Hippocampal synaptic plasticity is the basis of spatial memory and cognition and is strongly regulated by both testicular androgens (testosterone, T) and hippocampal estrogens (17β-estradiol, E2) converted from T by aromatase, which is inhibited by letrozole (LET), but the contribution of each pathway to spatial memory and the associated mechanisms are unclear. In this study, we first used orchiectomy (ORX) and LET injection to investigate the effects of T and hippocampal E2 on spatial memory and hippocampal synaptic plasticity...
April 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29420715/modulation-of-nuclear-receptor-function-by-chromatin-modifying-factor-tip60
#15
Bharti Jaiswal, Ashish Gupta
Nuclear receptors are transcription factors that binds to specific DNA sequences known as hormone response elements located upstream of their target genes. Transcriptional activity of NRs can be modulated by binding of the compatible ligand and transient interaction with cellular coregulators functioning either as coactivators or as corepressors. Many coactivator proteins possess intrinsic histone acetyl transferase (HAT) activity that catalyzes the acetylation of specific lysine residues in histone tails and loosens the histone-DNA interaction thereby facilitating access of transcriptional factors to the regulatory sequences of the DNA...
February 6, 2018: Endocrinology
https://www.readbyqxmd.com/read/29367763/network-analysis-of-src-1-reveals-a-novel-transcription-factor-hub-which-regulates-endocrine-resistant-breast-cancer
#16
Alacoque L Browne, Sara Charmsaz, Damir Varešlija, Ailis Fagan, Nicola Cosgrove, Sinéad Cocchiglia, Siobhan Purcell, Elspeth Ward, Fiona Bane, Lance Hudson, Arnold D Hill, Jason S Carroll, Aisling M Redmond, Leonie S Young
Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and metastasise. Here we took a top-down discovery approach to map out the SRC-1 transcriptional network in endocrine resistant breast cancer. First, rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) was employed to uncover new SRC-1 TF partners. Next, RNA sequencing (RNAseq) was undertaken to investigate SRC-1 TF target genes...
January 25, 2018: Oncogene
https://www.readbyqxmd.com/read/29330934/melatonin-inhibits-the-proliferation-of-breast-cancer-cells-induced-by-bisphenol-a-via-targeting-estrogen-receptor-related-pathways
#17
Tianjiao Wang, Bowen Liu, Yanan Guan, Miaomiao Gong, Weiying Zhang, Jinjin Pan, Yanan Liu, Rui Liang, Yuhui Yuan, Lihong Ye
BACKGROUND: Background: Bisphenol A (BPA) is an estrogen-like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone-related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen-induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA-induced proliferation of estrogen receptor-positive BC cells...
March 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29309722/a-cell-permeable-stapled-peptide-inhibitor-of-the-estrogen-receptor-coactivator-interaction
#18
Thomas E Speltz, Jeanne M Danes, Joshua D Stender, Jonna Frasor, Terry W Moore
We and others have proposed that coactivator binding inhibitors, which block the interaction of estrogen receptor and steroid receptor coactivators, may represent a potential class of new breast cancer therapeutics. The development of coactivator binding inhibitors has been limited, however, because many of the current molecules which are active in in vitro and biochemical assays are not active in cell-based assays. Our goal in this work was to prepare a coactivator binding inhibitor active in cellular models of breast cancer...
March 16, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29282318/src1-promotes-th17-differentiation-by-overriding-foxp3-suppression-to-stimulate-ror%C3%AE-t-activity-in-a-pkc-%C3%AE-dependent-manner
#19
Subha Sen, Fei Wang, Jing Zhang, Zhiheng He, Jian Ma, Yousang Gwack, Jianming Xu, Zuoming Sun
Th17 cells are major players in multiple autoimmune diseases and are developmentally contingent on reciprocal functionality between the transcription factor Retineic acid receptor-related orphan nuclear receptor gamma (RORγt) and Forkhead box protein P3 (Foxp3). Here we deciphered a previously unappreciated role of Steroid receptor coactivator 1 (SRC1) in defining the lineage decision for the development of Th17 versus induced T-regulatory (iTreg) cells. We demonstrate that SRC1 functions as a critical coactivator for RORγt in vivo to promote the functional dominance of RORγt over Foxp3 and thus establishing an unopposed Th17 differentiation program...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229683/mesenchymal-stem-cells-promote-endothelial-progenitor-cell-migration-vascularization-and-bone-repair-in-tissue-engineered-constructs-via-activating-cxcr2-src-pkl-vav2-rac1
#20
Zhilin Li, Aijun Yang, Xiaolong Yin, Shiwu Dong, Fei Luo, Ce Dou, Xu Lan, Zhao Xie, Tianyong Hou, Jianzhong Xu, Junchao Xing
Tissue-engineered constructs (TECs) hold great promise for treating large bone defects. Incorporated mesenchymal stem cells (MSCs) can facilitate the vascularization of TECs. Nevertheless, the underlying mechanism remains ambiguous. Here we analyzed the roles of C-X-C chemokine receptor 2 (CXCR2) and its downstream signal pathways in MSC-induced endothelial progenitor cell (EPC) migration. Transwell assays and immunofluorescence staining were performed for cell migration analysis in vitro and in vivo, respectively...
January 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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