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Steroid receptor coactivator

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https://www.readbyqxmd.com/read/28053238/steroid-receptor-coactivator-3-contributes-to-host-defense-against-enteric-bacteria-by-recruiting-neutrophils-via-upregulation-of-cxcl2-expression
#1
Wenbo Chen, Xuqiang Lu, Yuan Chen, Ming Li, Pingli Mo, Zhangwei Tong, Wei Wang, Wei Wan, Guoqiang Su, Jianming Xu, Chundong Yu
Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors and some other transcription factors to enhance their effects on target gene transcription. We reported previously that SRC-3-deficient (SRC-3(-/-)) mice are extremely susceptible to Escherichia coli-induced septic peritonitis as a result of uncontrolled inflammation and a defect in bacterial clearance. In this study, we observed significant upregulation of SRC-3 in colonic epithelial cells in response to Citrobacter rodentium infection...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28042453/design-and-synthesis-of-selective-small-molecule-inhibitors-of-coactivator-associated-arginine-methyltransferase-1-carm1
#2
H Ü Kaniskan, M S Eram, J Liu, D Smil, M L Martini, Y Shen, V Santhakumar, P J Brown, C Arrowsmith, M Vedadi, J Jin
Coactivator-associated arginine methyltransferase 1 (CARM1) is a type I protein arginine methyltransferase (PRMT) that catalyzes the conversion of arginine into monomethylarginine (MMA) and further into asymmetric dimethylarginine (ADMA). CARM1 methylates histone 3 arginines 17 and 26, as well as numerous non-histone proteins including CBP/p300, SRC-3, NCOA2, PABP1, and SAP49, while also functioning as a coactivator for various proteins that have been linked to cancer such as p53, NF-κβ, β-catenin, E2F1 and steroid hormone receptor ERα...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28006821/src-1-regulates-blood-pressure-and-aortic-stiffness-in-female-mice
#3
Antentor Othrell Hinton, Yongjie Yang, Ann P Quick, Pingwen Xu, Chitra L Reddy, Xiaofeng Yan, Corey L Reynolds, Qingchun Tong, Liangru Zhu, Jianming Xu, Xander H T Wehrens, Yong Xu, Anilkumar K Reddy
Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood pressure. We used immunohistochemistry to map the expression of steroid receptor coactivator-1 protein in mouse brain, especially in regions implicated in the regulation of blood pressure. Steroid receptor coactivator-1 protein was found in central amygdala, medial amygdala, supraoptic nucleus, arcuate nucleus, ventromedial, dorsomedial, paraventricular hypothalamus, and nucleus of the solitary tract...
2016: PloS One
https://www.readbyqxmd.com/read/27880726/chrysophanic-acid-reduces-testosterone-induced-benign-prostatic-hyperplasia-in-rats-by-suppressing-5%C3%AE-reductase-and-extracellular-signal-regulated-kinase
#4
Dong-Hyun Youn, Jinbong Park, Hye-Lin Kim, Yunu Jung, JongWook Kang, Mi-Young Jeong, Gautam Sethi, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27877220/aib1-genomic-amplification-predicts-poor-clinical-outcomes-in-female-glioma-patients
#5
Lihong Chen, Changwei Wang, Xinyuan Zhang, Ke Gao, Rui Liu, Bingyin Shi, Peng Hou
Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas as control subjects were enrolled, and the copy number of AIB1 was analyzed in these samples. In addition, we explored potential correlation of AIB1 amplification with clinicopathological characteristics and clinical outcomes of glioma patients...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27866972/letrozole-regulates-actin-cytoskeleton-polymerization-dynamics-in-a-src-1-dependent-manner-in-the-hippocampus-of-mice
#6
Yangang Zhao, Yanlan Yu, Yuanyuan Zhang, Li He, Linli Qiu, Jikai Zhao, Mengying Liu, Jiqiang Zhang
In the hippocampus, local estrogens (E2) derived from testosterone that is catalyzed by aromatase play important roles in the regulation of hippocampal neural plasticity, but the underlying mechanisms remain unclear. The actin cytoskeleton contributes greatly to hippocampal synaptic plasticity; however, whether it is regulated by local E2 and the related mechanisms remain to be elucidated. In this study, we first examined the postnatal developmental profiles of hippocampal aromatase and specific proteins responsible for actin cytoskeleton dynamics...
March 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27826038/expression-of-glial-cbp-in-steroid-mediated-neuroprotection-in-male-and-female-zebra-finches
#7
Molly Klores, John T Moon, Kelli A Duncan
Under neurodegenerative conditions, reactive astrocytes upregulate both aromatase (estrogen synthase) as well as estrogen and androgen receptors. This increased steroidogenic signal promotes neuroprotection and repair by promoting neurogenesis and decreasing cell death, but also by modulating the release of inflammatory molecules. Thus, endocrine - immune cross-talk is an essential component of estrogen mediated neuroprotection following brain injury. However, the exact mechanisms underlying this cross-talk remains unknown...
January 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27781415/overexpression-of-src-3-promotes-esophageal-squamous-cell-carcinoma-aggressiveness-by-enhancing-cell-growth-and-invasiveness
#8
Fang-Ping Xu, Yan-Hui Liu, Xin-Lan Luo, Fen Zhang, Hai-Yu Zhou, Yan Ge, Chao Liu, Jie Chen, Dong-Lan Luo, Li-Xu Yan, Ping Mei, Jie Xu, Heng-Guo Zhuang
Steroid receptor coactivator-3 (SRC-3), a transcriptional coactivator for nuclear receptors and other transcription factors, plays an important role in the genesis and progression of several cancers. However, studies investigated the role of SRC-3 in esophageal squamous cell carcinomas (ESCCs) are limited, and the role of SRC-3 in tumor progression remains unclear. We examined the expression of SRC-3 in 8 ESCC cell lines and 302 human ESCC tissues by qPCR, Western blot, and immunohistochemistry. In addition, ESCC cell lines were subjected to proliferation and invasion assays, tumorigenicity assay, flow cytometry assay, qPCR, Western blot, and Chromatin Immunoprecipitation assay to investigate the role of SRC-3 in cancer progression...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27762340/juvenile-hormone-regulation-of-female-reproduction-in-the-common-bed-bug-cimex-lectularius
#9
Hemant Gujar, Subba Reddy Palli
To begin studies on reproduction in common bed bug, Cimex lectularius, we identified three genes coding for vitellogenin (Vg, a protein required for the reproductive success of insects) and studied their hormonal regulation. RNA interference studied showed that expression of Vg3 gene in the adult females is a prerequisite for successful completion of embryogenesis in the eggs laid by them. Juvenile hormone (JH) receptor, Methoprene-tolerant (Met), steroid receptor coactivator (SRC) and GATAa but not ecdysone receptor (EcR) or its partner, ultraspiracle (USP) are required for expression of Vg genes...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27694140/silencing-of-sra1-regulates-er-expression-and-attenuates-the-growth-of-stromal-cells-in-ovarian-endometriosis
#10
Kaiqing Lin, Hong Zhan, Junyan Ma, Kaihong Xu, Ruijin Wu, Caiyun Zhou, Jun Lin
Estradiol and its nuclear receptors, estrogen receptor (ER) α and ER-β, have important functions in endometriosis, and the transcriptional activity of these receptors is modulated by coactivators and corepressors. The steroid receptor RNA activator 1 (SRA1) produces SRA long noncoding RNA (lncRNA) and SRA protein (SRAP), which regulate ER expression at the RNA and protein levels in some hormone-dependent tumors via an alternative splicing event. However, only a few are reported on their expressions in endometriosis...
September 30, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27645900/small-molecule-adiponectin-receptor-agonist-gtdf-protects-against-skeletal-muscle-atrophy
#11
Abhishek Kumar Singh, Sonal Shree, Sourav Chattopadhyay, Sudhir Kumar, Anagha Gurjar, Sapana Kushwaha, Harish Kumar, Arun Kumar Trivedi, Naibedya Chattopadhyay, Rakesh Maurya, Ravishankar Ramachandran, Sabyasachi Sanyal
Skeletal muscle atrophy is a debilitating response to several major diseases, muscle disuse and chronic steroid treatment for which currently no therapy is available. Since adiponectin signaling plays key roles in muscle energetics, we assessed if globular adiponectin (gAd) or the small molecule adiponectin mimetic 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) could ameliorate muscle atrophy. Both GTDF and gAd induced C2C12 myoblast differentiation. GTDF and gAd effectively prevented reduction in myotube area and suppressed the expressions of atrophy markers; atrogin-1 and muscle ring finger protein-1 (MuRF1) in models of steroid, cytokine and starvation -induced muscle atrophy...
September 16, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27645313/class-i-lysine-deacetylases-promote-glucocorticoid-induced-transcriptional-repression-through-functional-interaction-with-lsd1
#12
Nina M Patrick, Chanel A Griggs, Ali L Icenogle, Maryam M Gilpatrick, Vineela Kadiyala, Rosa Jaime-Frias, Catharine L Smith
Small molecule inhibitors of lysine deacetylases (KDACs) are approved for clinical use in treatment of several diseases. Nuclear receptors, such as the glucocorticoid receptor (GR) use lysine acetyltransferases (KATs or HATs) and KDACs to regulate transcription through acetylation and deacetylation of protein targets such as histones. Previously we have shown that KDAC1 activity facilitates GR-activated transcription at about half of all cellular target genes. In the current study we examine the role of Class I KDACs in glucocorticoid-mediated repression of gene expression...
March 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27629593/fetal-to-maternal-signaling-in-the-timing-of-birth
#13
Carole R Mendelson, Alina P Montalbano, Lu Gao
Preterm birth remains the major cause of neonatal morbidity and mortality throughout the world. This is due, in part, to our incomplete understanding of the mechanisms that underlie the maintenance of pregnancy and the initiation of parturition at term. In this article, we review our current knowledge of the complex, interrelated and concerted mechanisms whereby progesterone maintains myometrial quiescence throughout most of pregnancy, as well as those that mediate the upregulation of the inflammatory response and decline in progesterone receptor function leading to parturition...
September 11, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27600294/3-hydroxyflavone-inhibits-human-osteosarcoma-u2os-and-143b-cells-metastasis-by-affecting-emt-and-repressing-u-pa-mmp-2-via-fak-src-to-mek-erk-and-rhoa-mlc2-pathways-and-reduces-143b-tumor-growth-in%C3%A2-vivo
#14
Ko-Hsiu Lu, Pei-Ni Chen, Yi-Hsien Hsieh, Chin-Yin Lin, Fu-Yuan Cheng, Peng-Chou Chiu, Shu-Chen Chu, Yih-Shou Hsieh
Many natural flavonoids have cytostatic and apoptotic properties; however, we little know whether the effect of synthetic 3-hydroxyflavone on metastasis and tumor growth of human osteosarcoma. Here, we tested the hypothesis that 3-hydroxyflavone suppresses human osteosarcoma cells metastasis and tumor growth. 3-hydroxyflavone, up to 50 μM without cytotoxicity, inhibited U2OS and 143B cells motility, invasiveness and migration by reducing matrix metalloproteinase (MMP)-2 and urokinase-type plasminogen activator (u-PA) and also impaired cell adhesion to gelatin...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27576059/daidzein-increases-opg-rankl-ratio-and-suppresses-il-6-in-mg-63-osteoblast-cells
#15
Jing Sun, Wei Jia Sun, Zheng Yang Li, Ling Li, Yue Wang, Yu Zhao, Cong Wang, Li Ren Yu, Ling Zhi Li, Yong Liang Zhang
Daidzein is a major dietary source of isoflavones found in Leguminosae, and belongs to the family of diphenolic compounds. The estrogenic effects of daidzein to prompt bone formation and prevent bone resorption have been observed in animal models and cultured cells. In our study, we studied the effects of daidzein, raloxifene and E2 on expression of the osteoblast-produced bone regulatory factors OPG, RANKL and IL-6 in human osteoblastic MG-63 cells. Results suggest that treatment with daidzein, raloxifene and E2 increased the levels of OPG and decreased those of RANKL and IL-6...
November 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27560800/multiple-functions-and-essential-roles-of-nuclear-receptor-coactivators-of-bhlh-pas-family
#16
REVIEW
L Pecenova, Robert Farkas
Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a large superfamily of transcription factors that participate virtually in every key biological process. They control various aspects of animal development, fertility, gametogenesis, and numerous metabolic pathways, and can be misregulated in many types of cancers...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27549514/cinnamomi-cortex-cinnamomum-verum-suppresses-testosterone-induced-benign-prostatic-hyperplasia-by-regulating-5%C3%AE-reductase
#17
Hyun-Myung Choi, Yunu Jung, Jinbong Park, Hye-Lin Kim, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jong-Hyun Lee, Woong Mo Yang, Seok-Geun Lee, Kwang Seok Ahn, Jae-Young Um
Cinnamomi cortex (dried bark of Cinnamomum verum) is an important drug in Traditional Korean Medicine used to improve blood circulation and Yang Qi. Benign prostatic hyperplasia (BPH) is a common chronic disease in aging men. This study was conducted to determine the effect of Cinnamomi cortex water extract (CC) on BPH. BPH was induced by a pre-4-week daily injection of testosterone propionate (TP). Six weeks of further injection with (a) vehicle, (b) TP, (c) TP + CC, (d) TP + finasteride (Fi) was carried on...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27534992/cholesterol-7%C3%AE-hydroxylase-protects-the-liver-from-inflammation-and-fibrosis-by-maintaining-cholesterol-homeostasis
#18
Hailiang Liu, Preeti Pathak, Shannon Boehme, John Y L Chiang
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of bile acids in hepatic inflammation and fibrosis remains unclear. In this study, we showed that adenovirus-mediated overexpression of Cyp7a1 ameliorated lipopolysaccharide (LPS)-induced inflammatory cell infiltration and pro-inflammatory cytokine production in WT and TGR5-deficient (Tgr5(-/-)) mice, but not in FXR-deficient (Fxr(-/-)) mice, suggesting that bile acid signaling through FXR protects against hepatic inflammation...
October 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27432117/genetic-and-environmental-models-of-circadian-disruption-link-src-2-function-to-hepatic-pathology
#19
Tiffany Fleet, Erin Stashi, Bokai Zhu, Kimal Rajapakshe, Kathrina L Marcelo, Nicole M Kettner, Blythe K Gorman, Cristian Coarfa, Loning Fu, Bert W O'Malley, Brian York
Circadian rhythmicity is a fundamental process that synchronizes behavioral cues with metabolic homeostasis. Disruption of daily cycles due to jet lag or shift work results in severe physiological consequences including advanced aging, metabolic syndrome, and even cancer. Our understanding of the molecular clock, which is regulated by intricate positive feedforward and negative feedback loops, has expanded to include an important metabolic transcriptional coregulator, Steroid Receptor Coactivator-2 (SRC-2), that regulates both the central clock of the suprachiasmatic nucleus (SCN) and peripheral clocks including the liver...
October 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27430721/ubiquitination-of-ror%C3%AE-t-at-lysine-446-limits-th17-differentiation-by-controlling-coactivator-recruitment
#20
Zhiheng He, Fei Wang, Jian Ma, Subha Sen, Jing Zhang, Yousang Gwack, Yu Zhou, Zuoming Sun
The transcription factor retinoid acid-related orphan receptor γ t (RORγt) directs the differentiation of Th17 cells. Th17 cells mediate pathological immune responses responsible for autoimmune diseases, including psoriasis and multiple sclerosis. Previous studies focused on RORγt target genes and their function in Th17 differentiation. In this study, we assessed posttranscriptional regulation of RORγt and identified a functional ubiquitination site, K446. Mutation of K446 to arginine to prevent ubiquitination greatly enhanced recruitment of steroid receptor coactivator 1 (SRC1), a coactivator critical for RORγt activity...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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