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water and salt metabolism in the geriatric

M Rainfray, S Richard-Harston, N Salles-Montaudon, J P Emeriau
PHYSIOLOGICAL AGING: Anatomical and physiological renal changes occur during normal aging in humans. These changes are different from the renal effects of many diseases frequently linked to aging and which require specific diagnosis, prevention and therapy. Renal aging varies from one patient to another or from one population to another. During common aging, anatomical changes are mild and physiological changes mainly affect glomerular filtration rate and water and salt metabolism regulation. IN THE ELDERLY: Glomerular filtration rate decreases slowly in healthy elderly people to reach 80 ml/mn at 80 years without any metabolic consequence...
July 8, 2000: La Presse M├ędicale
R H Dashwood
Chlorophyllin (CHL), a sodium/copper salt of chlorophyll used in the treatment of geriatric patients, exhibits potent antimutagenic activity in a range of assays in vitro and in vivo. The protective effects of CHL were studied in Sprague-Dawley rats using inhibition of carcinogen-DNA binding as an end-point. Animals were administered CHL (150 mg/kg body wt) and [2-14C]2-amino-3-methylimidazo[4,5-f]quinoline (IQ, 50 mg/kg body wt) by single oral gavage. Covalent IQ-DNA binding in liver was determined 8, 24 and 48 h after dosing; CHL inhibited binding at these times by 58, 56 and 46% respectively, compared with rats given IQ alone...
January 1992: Carcinogenesis
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