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https://www.readbyqxmd.com/read/29793173/ag-nanoparticles-loading-of-polypyrrole-coated-superwetting-mesh-for-on-demand-separation-of-oil-water-mixtures-and-catalytic-reduction-of-aromatic-dyes
#1
Sun Yihan, Liu Mingming, Zhiguang Guo
Herein, a catalytic mesh with unique wettability, high oil-water separation efficiency and excellent catalytic performance towards aromatic dyes was fabricated. Polypyrrole (PPy) was firstly pre-coated on pristine stainless-steel mesh (SSM) surface via cyclic voltammetry approach. Subsequently, a simple electrodeposition process was performed to prepare and anchor Ag nanoparticles (AgNPs) onto the PPy-coated SSM surface. The PPy-coated mesh with anchored AgNPs was denoted as PPy/AgNPs-coated SSM. The obtained PPy/AgNPs-coated SSM exhibited dual superlyophobic properties and were able to achieve on-demand separation to deal with various of light oil (ρoil  < ρwater ) and heavy oil (ρoil  > ρwater )-water mixtures...
May 19, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793088/decellularized-and-matured-esophageal-scaffold-for-circumferential-esophagus-replacement-proof-of-concept-in-a-pig-model
#2
Guillaume Luc, Guillaume Charles, Caroline Gronnier, Magali Cabau, Charlotte Kalisky, Mallory Meulle, Reine Bareille, Samantha Roques, Lionel Couraud, Johanna Rannou, Laurence Bordenave, Denis Collet, Marlène Durand
Surgical resection of the esophagus requires sacrificing a long portion of it. Its replacement by the demanding gastric pull-up or colonic interposition techniques may be avoided by using short biologic scaffolds composed of decellularized matrix (DM). The aim of this study was to prepare, characterize, and assess the in vivo remodeling of DM and its clinical impact in a preclinical model. A dynamic chemical and enzymatic decellularization protocol of porcine esophagus was set up and optimized. The resulting DM was mechanically and biologically characterized by DNA quantification, histology, and histomorphometry techniques...
May 17, 2018: Biomaterials
https://www.readbyqxmd.com/read/29792684/label-free-optical-marker-for-rbc-phenotyping-of-inherited-anaemias
#3
Martina Mugnano, Pasquale Memmolo, Lisa Miccio, Francesco Merola, Vittorio Bianco, Alessia Bramanti, Antonella Gambale, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Pietro Ferraro
The gold standard methods for anaemia diagnosis are the complete blood count and the peripheral smear observation. However, they do not allow for a complete differential diagnosis, which requires biochemical assays, thus being label-dependent techniques. On the other hand, recent studies focus on label-free quantitative phase imaging (QPI) of blood samples to investigate blood diseases by using video-based morphological methods. However, when sick cells are very similar to healthy ones in terms of morphometric features identification of a blood disease becomes challenging even by morphometric as well as QPI...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791871/network-based-disease-module-discovery-by-a-novel-seed-connector-algorithm-with-pathobiological-implications
#4
Rui-Sheng Wang, Joseph Loscalzo
Understanding the genetic basis of complex diseases is challenging. Prior work shows that disease-related proteins do not typically function in isolation. Rather, they often interact with each other to form a network module that underlies dysfunctional mechanistic pathways. Identifying such disease modules will provide insights into a systems-level understanding of molecular mechanisms of diseases. Owing to the incompleteness of our knowledge of disease proteins and limited information on the biological mediators of pathobiological processes, the key proteins (seed proteins) for many diseases appear scattered over the human protein-protein interactome and form a few small branches, rather than coherent network modules...
May 20, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29791140/correlative-stimulated-emission-depletion-and-scanning-ion-conductance-microscopy
#5
Philipp Hagemann, Astrid Gesper, Patrick Happel
Correlation microscopy combining fluorescence and scanning probe or electron microscopy is limited to fixed samples due to the sample preparation and non-physiological imaging conditions required by most probe or electron microscopy techniques. Among the few scanning probe techniques that allow imaging of living cells under physiological conditions, Scanning Ion Conductance Microscopy (SICM) has been shown to be the technique which minimizes the impact on the investigated sample. However, combinations of SICM and fluorescence microscopy suffered from the mismatch in resolution due to the limited resolution of conventional light microscopy...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791132/ptml-model-of-chembl-data-for-dopamine-targets-docking-synthesis-and-assay-of-new-plg-peptidomimetics
#6
Joana Ferreira da Costa, David Silva, Olga Caamaño, José M Brea, Maria Isabel Loza, Cristian R Munteanu, Alejandro Pazos, Xerardo García-Mera, Humbert González-Díaz
Predicting Drug-Protein Interactions (DPIs) for target proteins involved in Dopamine pathways is very important goal in medicinal chemistry. We can tackle this problem using Molecular Docking or Machine Learning (ML) models for one specific protein. Unfortunately, these models fail to account for large and complex Big Data sets of preclinical assays reported in public databases. This includes multiple conditions of assay like different experimental parameters, biological assays, target proteins, cell lines, organism of the target, organism of assay, etc...
May 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29791128/donor-acceptor-supramolecular-organic-nanofibers-as-visible-light-photoelectrocatalysts-for-hydrogen-production
#7
Liping Yang, Maomao Wang, Paul M Slattum, Benjamin R Bunes, Yuanhao Wang, Chuanyi Wang, Ling Zang
Perylene tetracarboxylic diimide (PTCDI) derivatives have been extensively studied for one-dimensional self-assembled systems and for applications in photocatalysis. Herein, we constructed a PTCDI-based donor-acceptor (D-A) supramolecular system via in situ self-assembly on an indium tin oxide (ITO) conductive glass surface. The self-assembled PTCDI nanostructures exhibit well-defined nanofibril morphologies and strong photocurrents. Interestingly, a strong and reversible electrochromic color change was observed during cyclic voltammetry (CV)...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790329/controllable-synthesis-of-multi-heteroatoms-co-doped-hierarchical-porous-carbon-spheres-as-an-ideal-catalysis-platform
#8
Shuliang Yang, Yanan Zhu, Changyan Cao, Li Peng, Wendy L Queen, Weiguo Song
The synthesis of porous carbon spheres with hierarchical porous structures coupled with the doping of heteroatoms is particularly important for advanced applications. In this research, a new route for efficient and controllable synthesis of hierarchical porous carbon spheres co-doped with nitrogen, phosphorus, and sulfur (denoted as NPS-HPCs) was reported. This new approach combines in situ polymerization of hexachlorocyclophosphazene and 4, 4'-sulfonyldiphenol with the self-assembly of colloidal silica nanoparticles (SiO2 NPs)...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790262/the-efficacy-and-tolerability-of-5-aminolevulinic-acid-5-thermosetting-gel-photodynamic-therapy-pdt-in-the-treatment-of-mild-to-moderate-acne-vulgaris-a-two-center-prospective-assessor-blinded-proof-of-concept-study
#9
Stefano Maria Serini, Maria Vittoria Cannizzaro, Annunziata Dattola, Virginia Garofalo, Esther Del Duca, Alessandra Ventura, Massimo Milani, Elena Campione, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease, commonly treated with topical or systemic drugs, according to the severity of the condition. Retinoids and antibiotic compounds are considered cornerstone approaches in this condition. However, low adherence to the therapy and the issue of bacterial resistance undermine the efficacy in the long term. Photodynamic therapy (PDT) with 20% aminolevulinic acid (ALA) has shown to be effective in the treatment of inflammatory acne...
May 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29789965/an-ultrasonically-controlled-switching-system-for-power-management-in-implantable-devices
#10
Jiawei Zhou, Albert Kim, Babak Ziaie
In this paper, we present an ultrasonically controlled switching system that can save the battery power for implantable devices by turning the system on and off, on-demand. Ultrasonic control is employed to reduce the device size, increase the penetration depth, and reduce misalignment sensitivity associated with alternative techniques using permanent magnet and RF signal. As a proof-of-concept demonstration, a 665 kHz ultrasonic signal is used to activate a piezoelectric receiver which in turn switches a battery-powered RF system on-and-off...
May 23, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29789916/two-dimensional-speckle-tracking-echocardiography-derived-strain-measurements-in-survivors-of-childhood-cancer-on-angiotensin-converting-enzyme-inhibition-or-receptor-blockade
#11
Jamie K Harrington, Marc E Richmond, Arielle W Fein, Serge Kobsa, Prakash Satwani, Amee Shah
Speckle tracking echocardiography (STE)-derived strain indices are believed to detect early cardiac dysfunction in survivors of childhood cancer and have potential to identify patients who may benefit from early heart failure treatment. However, effects of heart failure treatment on STE-derived strain measurements in this population are unknown. The aim of this study was to assess STE-derived strain measurements in survivors of childhood cancer treated with angiotensin converting enzyme inhibition or receptor blockade (ACEi/ARB)...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29789638/human-carbonic-anhydrase-8-aav8-gene-therapy-inhibits-nerve-growth-factor-signaling-producing-prolonged-analgesia-and-anti-hyperalgesia-in-mice
#12
Gerald Z Zhuang, Udita Upadhyay, Xiaoying Tong, Yuan Kang, Diana M Erasso, Eugene S Fu, Konstantinos D Sarantopoulos, Eden R Martin, Tim Wiltshire, Luda Diatchenko, Shad B Smith, William Maixner, Roy C Levitt
Carbonic anhydrase-8 (Car8; murine gene symbol) is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release. We previously reported that wild-type Car8 overexpression corrects the baseline allodynia and hyperalgesia associated with calcium dysregulation in the waddle (wdl) mouse due to a 19 bp deletion in exon 8 of the Car8 gene. In this report, we provide preliminary evidence that overexpression of the human wild-type ortholog of Car8 (CA8 WT ), but not the reported CA8 S100P loss-of-function mutation (CA8 MT ), inhibits nerve growth factor (NGF)-induced phosphorylation of ITPR1, TrkA (NGF high-affinity receptor), and ITPR1-mediated cytoplasmic free calcium release in vitro...
April 24, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29789569/value-added-transformation-of-ubiquitous-substrates-into-highly-efficient-and-flexible-electrodes-for-water-splitting
#13
Atharva Sahasrabudhe, Harsha Dixit, Rahul Majee, Sayan Bhattacharyya
Herein, we present an innovative approach for transforming commonly available cellulose paper into a flexible and catalytic current collector for overall water splitting. A solution processed soak-and-coat method of electroless plating was used to render a piece of paper conducting by conformably depositing metallic nickel nanoparticles, while still retaining the open macroporous framework. Proof-of-concept paper-electrodes are realized by modifying nickel-paper current collector with model electrocatalysts nickel-iron oxyhydroxide and nickel-molybdenum bimetallic alloy through electrodeposition route...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789410/a-randomised-open-label-parallel-group-phase-2-study-of-antisense-oligonucleotide-therapy-in-acromegaly
#14
Peter J Trainer, John Newell-Price, John Ayuk, Simon Aylwin, D Aled Rees, Wm Drake, Philippe Chanson, Thierry Brue, Susan M Webb, Carmen Fajardo Montañana, Javier Aller, Ann I McCormack, David J Torpy, George Tachas, Lynne Atley, David Ryder, Martin Bidlingmaier
OBJECTIVE: ATL1103 is a second-generation antisense oligomer targeting the human GH receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment for acromegaly. DESIGN: 26 patients with active acromegaly (IGF-I >130% upper limit of normal) were randomised to subcutaneous ATL1103 200 mg either once- or twice-weekly for 13 weeks, and monitored for a further 8-week washout period. METHODS: The primary efficacy measures were change in IGF-I at week 14, compared to baseline and between cohorts...
May 22, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29787970/functional-polyaniline-multiwalled-carbon-nanotube-composite-as-an-efficient-adsorbent-material-for-removing-pharmaceuticals-from-aqueous-media
#15
Flávia Viana Avelar Dutra, Bruna Carneiro Pires, Tienne Aparecida Nascimento, Keyller Bastos Borges
The composite polyaniline/multiwalled carbon nanotube (PAni/MWCNT, 1:0.1 w/w) was developed with the intention of binding the adsorbent properties of two materials and using it to adsorb pharmaceuticals from aqueous media. PAni/MWCNT was characterized by scanning electron microscopy, thermogravimetry, infrared spectroscopy, pH at the point of zero charge, and the effect on the surface wettability of the material. As proof of concept, adsorption studies were carried out using meloxicam (MLX) as the pharmaceutical and it was evaluated as a function of pH, temperature, ionic strength, contact time and variation in concentration...
May 19, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29787863/validity-of-targeted-next-generation-sequencing-in-routine-care-for-identifying-clinically-relevant-molecular-profiles-in-non-small-cell-lung-cancer-results-of-a-2-year-experience-on-1-343-samples
#16
Antoine Legras, Marc Barritault, Anne Tallet, Elizabeth Fabre, Alice Guyard, Bastien Rance, William Digan, Nicolas Pecuchet, Etienne Giroux-Leprieur, Catherine Julie, Stéphane Jouveshomme, Véronique Duchatelle, Véronique Giraudet, Laure Gibault, Alain Cazier, Jean Pastre, Françoise LE Pimpec-Barthes, Pierre Laurent-Puig, Hélène Blons
Theranostic assays are based on single gene testing but the ability of next-generation sequencing (NGS) to interrogate numerous genetic alterations will progressively replace single gene assays. Although NGS was evaluated to screen for theranostic mutations, its usefulness in clinical practice on large series of samples remains to be demonstrated. NGS performance was assessed following guidelines. TaqMan probes and NGS were compared for their ability to detect EGFR and KRAS mutations and NGS mutation profiles were analyzed on a large series of NSCLC (n=1,343)...
May 19, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29787588/angiogenic-and-pleiotropic-effects-of-vegf165-and-hgf-combined-gene-therapy-in-a-rat-model-of-myocardial-infarction
#17
Pavel I Makarevich, Konstantin V Dergilev, Zoya I Tsokolaeva, Maria A Boldyreva, Evgeniy K Shevchenko, Evgeny V Gluhanyuk, Julia O Gallinger, Mikhail Yu Menshikov, Yelena V Parfyonova
Since development of plasmid gene therapy for therapeutic angiogenesis by J. Isner this approach was an attractive option for ischemic diseases affecting large cohorts of patients. However, first placebo-controlled clinical trials showed its limited efficacy questioning further advance to practice. Thus, combined methods using delivery of several angiogenic factors got into spotlight as a way to improve outcomes. This study provides experimental proof of concept for a combined approach using simultaneous delivery of VEGF165 and HGF genes to alleviate consequences of myocardial infarction (MI)...
2018: PloS One
https://www.readbyqxmd.com/read/29787428/use-of-proteomic-and-hematology-biomarkers-for-prediction-of-hematopoietic-acute-radiation-syndrome-severity-in-baboon-radiation-models
#18
William F Blakely, David L Bolduc, Jeff Debad, George Sigal, Matthias Port, Michael Abend, Marco Valente, Michel Drouet, Francis Hérodin
Use of plasma proteomic and hematological biomarkers represents a promising approach to provide useful diagnostic information for assessment of the severity of hematopoietic acute radiation syndrome. Eighteen baboons were evaluated in a radiation model that underwent total-body and partial-body irradiations at doses of Co gamma rays from 2.5 to 15 Gy at dose rates of 6.25 cGy min and 32 cGy min. Hematopoietic acute radiation syndrome severity levels determined by an analysis of blood count changes measured up to 60 d after irradiation were used to gauge overall hematopoietic acute radiation syndrome severity classifications...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29787381/multi-atlas-based-segmentation-should-we-prefer-the-best-atlas-group-over-the-group-of-best-atlases
#19
Paolo Zaffino, Delia Ciardo, Patrik Raudaschl, Karl Fritscher, Rosalinda Ricotti, Daniela Alterio, Giulia Marvaso, Cristiana Fodor, Guido Baroni, Francesco Amato, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Gregory C Sharp, Maria Francesca Spadea
Multi Atlas Based Segmentation (MABS) uses a database of atlas images, and an atlas selection process is used to choose an atlas subset for registration and voting. In the current state of the art, atlases are chosen according to a similarity criterion between the target subject and each atlas in the database. In this paper, we propose a new concept for atlas selection that relies on selecting the best performing group of atlases rather than the group of highest scoring individual atlases.&#13; Experiments were performed using CT images of 50 patients, with contours of brainstem and parotid glands...
May 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29786648/utilizing-optimized-tools-to-investigate-ptm-crosstalk-identifying-potential-ptm-crosstalk-of-acetylated-mitochondrial-proteins
#20
Henrick Horita, Andy Law, Kim Middleton
Post-translational modification (PTM) crosstalk is recognized as a major cell-regulatory mechanism, and studies of several proteins have validated the premise that PTMs work in concert. Previous work by our group investigated the potential PTM crosstalk on proteins in the EGFR-Ras-c-Fos axis by utilizing a comprehensive set of PTM reagents termed Signal-Seeker toolkits. In this study, these tools were used to investigate the potential PTM crosstalk that occurs in acetylated mitochondrial proteins in response to a mitochondrial stress-inducing agent hydrogen peroxide (H₂O₂)...
May 22, 2018: Proteomes
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