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https://www.readbyqxmd.com/read/29168915/a-novel-microdevice-for-rapid-neutrophil-purification-and-phenotyping-in-type-2-diabetes-mellitus
#1
Hui Min Tay, Rinkoo Dalan, King Ho Holden Li, Bernhard O Boehm, Han Wei Hou
Neutrophil dysfunction is strongly linked to type 2 diabetes mellitus (T2DM) pathophysiology, but the prognostic potential of neutrophil biomarkers remains largely unexplored due to arduous leukocyte isolation methods. Herein, a novel integrated microdevice is reported for single-step neutrophil sorting and phenotyping (chemotaxis and formation of neutrophil extracellular traps (NETosis)) using small blood volumes (fingerprick). Untouched neutrophils are purified on-chip from whole blood directly using biomimetic cell margination and affinity-based capture, and are exposed to preloaded chemoattractant or NETosis stimulant to initiate chemotaxis or NETosis, respectively...
November 23, 2017: Small
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#2
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29168547/gastric-contractility-modulation-a-novel-method-for-the-treatment-of-type-2-diabetes-mellitus-and-obesity
#3
Jarosław Kozakowski, Harold E Lebovitz, Wojciech Zgliczyński, Wiesław Tarnowski
Because the majority of antidiabetic medications are of limited efficacy and patient compliance with treatment is usually poor, new therapies are still being searched for. In the review a newly developed system for treatment of subjects with type 2 diabetes and concomitant overweight/obesity is described. The system consists of an implantable pulse generator that delivers electrical stimuli through leads implanted in the sero-muscular layer of the stomach. The device recognises and automatically modulates natural electrical activity of the stomach during meals, strengthening gastric contractility...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29168475/chronic-kidney-disease
#4
REVIEW
Paola Romagnani, Giuseppe Remuzzi, Richard Glassock, Adeera Levin, Kitty J Jager, Marcello Tonelli, Ziad Massy, Christoph Wanner, Hans-Joachim Anders
Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural abnormalities or impaired excretory renal function suggestive of a loss of functional nephrons. The majority of patients with CKD are at risk of accelerated cardiovascular disease and death. For those who progress to end-stage renal disease, the limited accessibility to renal replacement therapy is a problem in many parts of the world. Risk factors for the development and progression of CKD include low nephron number at birth, nephron loss due to increasing age and acute or chronic kidney injuries caused by toxic exposures or diseases (for example, obesity and type 2 diabetes mellitus)...
November 23, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29168314/elevated-plasma-and-vitreous-levels-of-leucine-rich-%C3%AE-2-glycoprotein-are-associated-with-diabetic-retinopathy-progression
#5
Chong Chen, Xia Chen, Hengye Huang, Changjing Han, Yuan Qu, Huiyi Jin, Tian Niu, Yuan Zhang, Kun Liu, Xun Xu
PURPOSE: To investigate the association of plasma and vitreous leucine-rich-α2-glycoprotein (LRG1) with diabetic retinopathy (DR) progression. METHODS: A total of 86 outpatients and 33 inpatients were recruited. Outpatients with type 2 diabetes mellitus (T2DM) were classified as T2DM without DR (n = 22), nonproliferative DR (NPDR) (n = 20) and proliferative DR (PDR) (n = 22) based on international clinical DR severity scales. A total of 86 plasma and 33 vitreous samples were collected and subjected to enzyme-linked immunosorbent assay...
November 23, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29168157/perioperative-implications-of-sodium-glucose-cotransporter-2-inhibitors-a-case-series-of-euglycemic-diabetic-ketoacidosis-in-three-patients-after-cardiac-surgery
#6
Aaron Lau, Simon Bruce, Erica Wang, Ron Ree, Kevin Rondi, Anthony Chau
PURPOSE: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) comprise the newest class of oral hypoglycemic agents approved for treating type II diabetes mellitus (DM-II). Their use, however, has been associated with the rare development of euglycemic diabetic ketoacidosis (euDKA). We present three cases of euDKA that occurred following elective coronary artery bypass grafting surgery. The role of the anesthesiologist in the prevention, diagnosis, and management of this complication is also discussed...
November 22, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29168078/the-effect-of-hypergastrinemia-following-sleeve-gastrectomy-and-pantoprazole-on-type-2-diabetes-mellitus-and-beta-cell-mass-in-goto-kakizaki-rats
#7
E Grong, C Nord, I B Arbo, M Eriksson, B E Kulseng, U Ahlgren, R Mårvik
PURPOSE: Metabolic surgery alters the secretion of gastrointestinal hormones that influence glycemic control. Elevated gastrin has been suggested to benefit patients with type 2 diabetes and has been reported following sleeve gastrectomy in rats. The present study compares the effect of hypergastrinemia following sleeve gastrectomy with proton-pump inhibitor therapy on glycemic control and beta-cell mass in lean, diabetic animals. METHODS: Thirty-three diabetic Goto-Kakizaki rats were randomized into pantoprazole + sham operation (GK-PPI), sleeve gastrectomy (GK-SG) and vehicle + sham operation (GK-V)...
November 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29167582/pyridoxine-dipharmacophore-derivatives-as-potent-glucokinase-activators-for-the-treatment-of-type-2-diabetes-mellitus
#8
Mikhail S Dzyurkevich, Denis A Babkov, Nikita V Shtyrlin, Olga Yu Mayka, Alfiya G Iksanova, Pavel M Vassiliev, Konstantin V Balakin, Alexander A Spasov, Vadim V Tarasov, George Barreto, Yurii G Shtyrlin, Gjumrakch Aliev
Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 diabetes mellitus. In this work, a series of novel symmetric molecular constructs, in which two pyridoxine moieties are connected via sulfur-containing linkers, have been synthesized and tested in vitro for glucokinase activation potential. The enzyme activation rates by two most active compounds at 100 μM (~150% and 130%) were comparable to that of the reference agent PF-04937319 (~154%)...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167212/cardiovascular-disease-cancer-and-mortality-among-people-with-type-2-diabetes-and-alcoholic-or-nonalcoholic-fatty-liver-disease-hospital-admission
#9
Sarah H Wild, Jeremy J Walker, Joanne R Morling, David A McAllister, Helen M Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H Read, Naveed Sattar, Christopher D Byrne
OBJECTIVE: To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people ages 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records...
November 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29166415/prognosis-of-type-1-autoimmune-pancreatitis-after-corticosteroid-therapy-induced-remission-in-terms-of-relapse-and-diabetes-mellitus
#10
Masaki Miyazawa, Hajime Takatori, Tetsuro Shimakami, Kazunori Kawaguchi, Kazuya Kitamura, Kuniaki Arai, Koichiro Matsuda, Taku Sanada, Takeshi Urabe, Katsuhisa Inamura, Takashi Kagaya, Hideki Mizuno, Uichiro Fuchizaki, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND AND AIM: Relapse and diabetes mellitus (DM) are major problems for the prognosis of autoimmune pancreatitis (AIP). We examined the prognosis of type 1 AIP after corticosteroid therapy (CST)-induced remission in terms of relapse and DM. METHODS: The study enrolled 82 patients diagnosed with type 1 AIP who achieved remission with CST. We retrospectively evaluated the relapse rate in terms of the administration period of CST, clinical factors associated with relapse, and the temporal change in glucose tolerance...
2017: PloS One
https://www.readbyqxmd.com/read/29166392/intestinal-ralstonia-pickettii-augments-glucose-intolerance-in-obesity
#11
Shanthadevi D Udayappan, Petia Kovatcheva-Datchary, Guido J Bakker, Stefan R Havik, Hilde Herrema, Patrice D Cani, Kristien E Bouter, Clara Belzer, Julia J Witjes, Anne Vrieze, Noor de Sonnaville, Alice Chaplin, Daniel H van Raalte, Steven Aalvink, Geesje M Dallinga-Thie, Hans G H J Heilig, Göran Bergström, Suzan van der Meij, Bart A van Wagensveld, Joost B L Hoekstra, Frits Holleman, Erik S G Stroes, Albert K Groen, Fredrik Bäckhed, Willem M de Vos, Max Nieuwdorp
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent...
2017: PloS One
https://www.readbyqxmd.com/read/29165869/canagliflozin-stability-study-and-eco-friendly-chromatographic-determination-of-its-degradation-product-a-comparative-study
#12
Aml A Emam
Canagliflozin is a newly approved drug for type II diabetes mellitus. A full stability study of Canagliflozin was performed following international conference on harmonization strategies. The drug was stable against all conditions except oxidation where only one degradation product was separated and structurally elucidated using mass spectrometry and IR spectroscopy. A green high-performance thin-layer chromatographic densitometric determination was developed and validated for the accurate quantification of Canagliflozin and its main oxidative degradation product...
November 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29165096/depression-and-self-efficacy-in-patients-with-type-2-diabetes-in-nothern-greece
#13
Paraskevi Sympa, Eugenia Vlachou, Kyriakos Kazakos, Ourania Govina, George Stamatiou, Maria Lavdaniti
BACKGROUND: Depression represents one of the most common disorders in diabetic patients and frequently complicates the health care of this population. Poor self-efficacy has been associated with increased depressive symptoms as well as poor glycemic control. OBJECTIVE: Τo assess depression and self-efficacy in adults with type 2 diabetes in Northern Greece and to explore the factors which may affect them in this group of population. METHOD: A descriptive study was conducted in a tertiary hospital in the largest city of Northern Greece...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29164973/an-indirect-treatment-comparison-of-the-efficacy-of-insulin-degludec-liraglutide-ideglira-and-insulin-glargine-lixisenatide-iglarlixi-in-patients-with-type-2-diabetes-uncontrolled-on-basal-insulin
#14
Marc Evans, Liana K Billings, Jonas Håkan-Bloch, Ulla Slothuus, Trine J Abrahamsen, Andreas Andersen, Jeroen P Jansen
AIMS: To obtain estimates of the relative treatment effects between insulin degludec/liraglutide (IDegLira) and insulin glargine U100/lixisenatide (iGlarLixi) in patients with type 2 diabetes mellitus (T2DM) uncontrolled on basal insulin therapy. MATERIALS AND METHODS: Data from phase 3 trials providing evidence for estimating the relative efficacy and safety of IDegLira versus iGlarLixi in patients uncontrolled on basal insulin-only regimens were used in this analysis...
November 22, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/29164512/individuals-with-type-1-and-type-2-diabetes-mellitus-trade-increased-hyperglycemia-for-decreased-hypoglycemia-when-glycemic-variability-is-not-improved
#15
Sujit R Jangam, Gary Hayter, Timothy C Dunn
INTRODUCTION: Glycemic variability refers to oscillations in blood glucose within a day and differences in blood glucose at the same time on different days. Glycemic variability is linked to hypoglycemia and hyperglycemia. The relationship among these three important metrics is examined here, specifically to show how reduction in both hypo- and hyperglycemia risk is dependent on changes in variability. METHODS: To understand the importance of glycemic variability in the simultaneous reduction of hypoglycemia and hyperglycemia risk, we introduce the glycemic risk plot-estimated HbA1c % (eA1c) vs...
November 21, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29164153/sirt1-regulates-cognitive-performance-and-ability-of-learning-and-memory-in-diabetic-and-nondiabetic-models
#16
REVIEW
Yue Cao, Zi Yan, Tong Zhou, Guixia Wang
Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29163948/the-heart-matters-in-diabetes-10-year-outcomes-of-peripheral-artery-disease
#17
Thomas Mueller, Franz Hinterreiter, Werner Poelz, Meinhard Haltmayer, Benjamin Dieplinger
Objectives: Mortality rates at 10 years are higher in diabetic patients with chronic lower extremity peripheral arterial disease than in non-diabetic peripheral arterial disease patients. We tested the hypothesis that the predictors of mortality differ between diabetic and non-diabetic peripheral arterial disease patients. Methods: We studied 331 consecutive patients who were <75 years of age, symptomatic for peripheral arterial disease, and admitted to a tertiary care hospital...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163736/association-of-glycosylated-hemoglobin-levels-with-vitamin-d-status
#18
Badurudeen Mahmood Buhary, Ohoud Almohareb, Naji Aljohani, Saleh Alrajhi, Samer Elkaissi, Suphia Sherbeeni, Abdulrahman Almaghamsi, Shawana Abdulhamid Khan, Mussa H Almalki
Background: The discovery of vitamin D is one of medicine's great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D levels are associated with poorer glucose control in diabetes mellitus (DM) patients and to investigate the effect of vitamin D supplementation on HbA1c levels...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163733/can-antioxidative-status-be-involved-in-type-1-diabetes
#19
Cintia Castro-Correia, M Luz Maia, Sonia Norberto, Cristina Costa-Santos, M Fatima Barroso, Ana Carvalho, Manuel Fontoura, Valentina Domingues, Conceicao Calhau
Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with beta-cell destruction, resulting in insulin deficiency. It is now clear that environmental factors also play a role in disease development. The prevalence of type 1 diabetes in children and young people in Portugal is 0.16% between 0 and 19 years of age. The main cause of death in T1DM is cardiovascular disease, and early endothelial dysfunction is its pathophysiologycal precursor. Hyperglycemia is associated with increased production of free radicals and increased oxidative stress...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29163673/effects-of-pioglitazone-therapy-on-blood-parameters-weight-and-bmi-a-meta-analysis
#20
REVIEW
Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
Background: Type 2 diabetes mellitus (T2DM) is one of the most common diseases worldwide and insulin insufficiency and insulin resistance are two main metabolic issues connected with it. The dyslipidemia associated with insulin resistance and T2DM is characterized by higher triglycerides (TGs), higher very-low-density lipoprotein cholesterol and lower apo A1. Pioglitazone, a member of the thiazolidinedione class, with a proven antihyperglycemic effect, is known to positively influence insulin sensitivity and β-cell function and to have the potential to alter the lipid profile...
2017: Diabetology & Metabolic Syndrome
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