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https://www.readbyqxmd.com/read/28431034/effects-of-sleep-loss-on-subjective-complaints-and-objective-neurocognitive-performance-as-measured-by-the-immediate-post-concussion-assessment-and-cognitive-testing
#1
Ryan P J Stocker, Hassen Khan, Luke Henry, Anne Germain
Objective: This study examined the effects of total and partial sleep deprivation on subjective symptoms and objective neurocognitive performance, as measured by the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) in a sample of healthy adults. Method: One-hundred and two, right-handed, healthy participants (between ages 18 and 30 years old) completed three consecutive nights in the sleep laboratory with concurrent continuous polysomnography monitoring...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28424947/neurodevelopmental-effects-of-antiepileptic-drugs
#2
Marissa Kellogg, Kimford J Meador
Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during critical periods of development may induce transient or long-lasting neurodevelopmental deficits across cognitive, motor and behavioral domains. The developing nervous system may endure prolonged chronic exposure to AEDs during pregnancy (in utero) or during childhood, which can lead to neurodevelopmental defects such as congenital neural tube defects, lower IQ, language deficits, autism and ADHD. To date, valproate is the most widely recognized AED to significantly negatively affect neurodevelopment, and demonstrates greater adverse effects than any other AEDs that have been assessed...
April 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28424357/thin-for-gestational-age-infants-are-at-increased-risk-of-neurodevelopmental-delay-at-2%C3%A2-years
#3
Sinéad M O'Neill, Geraldine Hannon, Ali S Khashan, J O'B Hourihane, Louise C Kenny, Mairead Kiely, Deirdre M Murray
BACKGROUND: Infants born small-for-gestational age (SGA) are at increased risk of developmental difficulties. Identifying those most at risk is challenging. We examined the effect of neonatal body composition and customised birthweight centiles on neurocognitive and behavioural outcomes at age 2. STUDY DESIGN: Prospective cohort study of term infants from the Cork BASELINE Birth Cohort Study classified into the following exposure groups: a birth weight <10th customised centile (SGA, n=51); body fat percentage at birth <10th centile (thin-for-gestational age (TGA, n=51)) or both SGA and TGA infants (small- and thin-for-gestational age (STGA), n=13)...
May 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28424177/developmental-and-behavioural-associations-of-burns-and-scalds-in-children-a-prospective-population-based-study
#4
Alan Emond, Clare Sheahan, Julie Mytton, Linda Hollén
OBJECTIVE: To investigate child developmental and behavioural characteristics and risk of burns and scalds. DESIGN: Data on burns in children up to 11 years from 12 966 participants in the Avon Longitudinal Study of Parents and Children were linked to developmental profiles measured before the burn injury. MEASURES: Preinjury profiles of the children derived from maternal questionnaires completed in pregnancy, and at 6, 18, 42, 47 and 54 months...
May 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28420388/association-between-maternal-intake-of-n-6-to-n-3-fatty-acid-ratio-during-pregnancy-and-infant-neurodevelopment-at-6-months-of-age-results-of-the-moceh-cohort-study
#5
Hyejin Kim, Hyesook Kim, Eunjung Lee, Yeni Kim, Eun-Hee Ha, Namsoo Chang
BACKGROUND & AIMS: Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for infant neurodevelopment. The nutritional adequacy of dietary LC-PUFAs depends not only on the LC-PUFAs intake but also on the n-6 to n-3 fatty acid ratio (n-6/n-3 PUFAs). This study aimed to identify the association between the maternal dietary n-6/n-3 PUFAs and motor and cognitive development of infants at 6 months of age. METHODS: We used data from 960 participants in the Mothers and Children's Environmental Health (MOCEH) study, which is a multi-center prospective cohort study...
April 18, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28413713/catastrophic-outcome-of-patients-with-a-rebound-after-natalizumab-treatment-discontinuation
#6
Inés González-Suarez, Luis Rodríguez de Antonio, Aida Orviz, Sara Moreno-García, María D Valle-Arcos, Jordi A Matias-Guiu, Cristina Valencia, Manuela Jorquera Moya, Celia Oreja-Guevara
INTRODUCTION: Natalizumab (NTZ) is an effective drug for the treatment of relapsing-remitting multiple sclerosis. In some patients discontinuation is mandatory due to the risk of progressive multifocal leukoencephalopathy. However, severe clinical and radiological worsening has been described after drug cessation. Our aim was to describe the clinical and radiological features of the rebound phenomenon. MATERIAL AND METHODS: Patients switched from NTZ to Fingolimod (FTY) who had presented a rebound after discontinuation were selected...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28413688/presentation-and-care-of-a-family-with-huntington-disease-in-a-resource-limited-community
#7
Jarmal Charles, Lindyann Lessey, Jennifer Rooney, Ingmar Prokop, Katherine Yearwood, Hazel Da Breo, Patrick Rooney, Ruth H Walker, Andrew K Sobering
BACKGROUND: In high-income countries patients with Huntington disease (HD) typically present to healthcare providers after developing involuntary movements, or for pre-symptomatic genetic testing if at familial risk. A positive family history is a major guide when considering the decision to perform genetic testing for HD, both in affected and unaffected patients. Management of HD is focused upon control of symptoms, whether motor, cognitive, or psychiatric. There is no clear evidence to date of any disease-modifying agents...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28408725/screening-for-developmental-delay-in-preschool-aged-children-using-parent-completed-ages-and-stages-questionnaires-additional-insights-into-child-development
#8
Soheir S Abo El Elella, Maha A M Tawfik, Wafaa Moustafa M Abo El Fotoh, Naglaa Fathy Barseem
BACKGROUND: Developmental delay is a delay in areas of speech, language, motor, social and cognitive development. Because of the negative impact of intellectual and learning disabilities, early identification of children with developmental and behavioral problems using appropriate screening tests is crucial. OBJECTIVES: Utilization of parent-completed Ages and Stages Questionnaires (ASQs) for detecting the developmental delay in preschool age children and clarification of possible associated risk factors...
April 13, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28407503/parkinsonian-signs-are-a-risk-factor-for-falls
#9
Nabila Dahodwala, Chinwe Nwadiogbu, Whitney Fitts, Helen Partridge, Jason Karlawish
BACKGROUND: Parkinsonian signs are common, non-specific findings in older adults and associated with increased rates of dementia and mortality. It is important to understand which motor outcomes are associated with parkinsonian signs. OBJECTIVES: To determine the role of parkinsonian signs on fall rates among older adults. METHODS: We conducted a longitudinal study of primary care patients from the University of Pennsylvania Health System...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28392082/neglect-as-a-violation-of-species-expectant-experience-neurodevelopmental-consequences
#10
REVIEW
Katie A McLaughlin, Margaret A Sheridan, Charles A Nelson
The human brain requires a wide variety of experiences and environmental inputs in order to develop normally. Children who are neglected by caregivers or raised in institutional environments are deprived of numerous types of species-expectant environmental experiences. In this review, we articulate a model of how the absence of cognitive stimulation and sensory, motor, linguistic, and social experiences common among children raised in deprived early environments constrains early forms of learning, producing long-term deficits in complex cognitive function and associative learning...
February 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28386652/interventions-to-promote-fundamental-movement-skills-in-childcare-and-kindergarten-a-systematic-review-and-meta-analysis
#11
REVIEW
Kristin Wick, Claudia S Leeger-Aschmann, Nico D Monn, Thomas Radtke, Laura V Ott, Cornelia E Rebholz, Sergio Cruz, Natalie Gerber, Einat A Schmutz, Jardena J Puder, Simone Munsch, Tanja H Kakebeeke, Oskar G Jenni, Urs Granacher, Susi Kriemler
BACKGROUND: Proficiency in fundamental movement skills (FMS) lays the foundation for being physically active and developing more complex motor skills. Improving these motor skills may provide enhanced opportunities for the development of a variety of perceptual, social, and cognitive skills. OBJECTIVE: The objective of this systematic review and meta-analysis was to assess the effects of FMS interventions on actual FMS, targeting typically developing young children...
April 6, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28385478/quantitative-electroencephalogram-measures-in-adult-obstructive-sleep-apnea-potential-biomarkers-of-neurobehavioural-functioning
#12
REVIEW
Angela L D'Rozario, Nathan E Cross, Andrew Vakulin, Delwyn J Bartlett, Keith K H Wong, David Wang, Ronald R Grunstein
Obstructive sleep apnea (OSA) results in significantly impaired cognitive functioning and increased daytime sleepiness in some patients leading to increased risk of motor vehicle and workplace accidents and reduced productivity. Clinicians often face difficulty in identifying which patients are at risk of neurobehavioural dysfunction due to wide inter-individual variability, and disparity between symptoms and conventional metrics of disease severity such as the apnea hypopnea index. Quantitative electroencephalogram (EEG) measures are determinants of awake neurobehavioural function in healthy subjects...
October 19, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28370517/the-prodromal-phase-of-leucine-rich-repeat-kinase-2-associated-parkinson-disease-clinical-and-imaging-studies
#13
Claustre Pont-Sunyer, Eduardo Tolosa, Chelsea Caspell-Garcia, Christopher Coffey, Roy N Alcalay, Piu Chan, John E Duda, Maurizio Facheris, Rubén Fernández-Santiago, Kenneth Marek, Francisco Lomeña, Connie Marras, Elisabet Mondragon, Rachel Saunders-Pullman, Bjorg Waro
BACKGROUND: Asymptomatic, nonmanifesting carriers of leucine-rich repeat kinase 2 mutations are at increased risk of developing PD. Clinical and neuroimaging features may be associated with gene carriage and/or may demarcate individuals at greater risk for phenoconversion to PD. OBJECTIVES: To investigate clinical and dopamine transporter single-photon emission computed tomography imaging characteristics of leucine-rich repeat kinase 2 asymptomatic carriers. METHODS: A total of 342 carriers' and 259 noncarriers' relatives of G2019S leucine-rich repeat kinase 2/PD patients and 39 carriers' and 31 noncarriers' relatives of R1441G leucine-rich repeat kinase 2/PD patients were evaluated...
March 28, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28367776/mild-cognitive-impairment-subtypes-in-a-cohort-of-elderly-essential-tremor-cases
#14
Kathleen Collins, Brittany Rohl, Sarah Morgan, Edward D Huey, Elan D Louis, Stephanie Cosentino
OBJECTIVES: Individuals with essential tremor (ET) exhibit a range of cognitive deficits generally conceptualized as "dysexecutive" or "fronto-subcortical," and thought to reflect disrupted cortico-cerebellar networks. In light of emerging evidence that ET increases risk for Alzheimer's disease (AD), it is critical to more closely examine the nature of specific cognitive deficits in ET, with particular attention to amnestic deficits that may signal early AD. METHODS: We performed a cross-sectional analysis of baseline data from 128 ET cases (age 80...
April 3, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28353277/clinical-features-of-lrrk2-carriers-with-parkinson-s-disease
#15
Meir Kestenbaum, Roy N Alcalay
LRRK2 mutations are present in 1% of all sporadic Parkinson's disease (PD) cases and 5% of all familial PD cases. Several mutations in the LRRK2 gene are associated with PD, the most common of which is the Gly2019Ser mutation. In the following review, we summarize the demographics and motor and non-motor symptoms of LRRK2 carriers with PD, as well as symptoms in non-manifesting carriers. The clinical features of LRRK2-associated PD are often indistinguishable from those of idiopathic PD on an individual basis...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28352181/neuropsychiatric-symptoms-in-untreated-parkinson-s-disease
#16
REVIEW
Szabolcs Szatmari, Ben Min-Woo Illigens, Timo Siepmann, Alexandra Pinter, Annamaria Takats, Daniel Bereczki
Neuropsychiatric and cognitive symptoms are common in Parkinson's disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28339607/gross-motor-trajectories-during-the-first-year-of-life-for-preterm-infants-with-very-low-birth-weight
#17
Yu-Han Su, Suh-Fang Jeng, Wu-Shiun Hsieh, Yu-Kang Tu, Yen-Tzu Wu, Li-Chiou Chen
Background: Early identification of motor dysfunction in preterm infants with very low birth weight (VLBW) is important in order to provide early intervention. Objective: This study was to examine the motor trajectories of preterm infants with VLBW during their first year of life and to investigate the predictive ability and influencing factors of the trajectories. Design and Methods: A total of 342 preterm infants with VLBW were prospectively assessed for motor development by the Alberta Infant Motor Scales at 4, 6, 9, and 12 months and for developmental outcomes using the Bayley Scales of Infant and Toddler Development, second edition, at 24 months...
March 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28334392/validation-of-the-nih-toolbox-in-individuals-with-neurologic-disorders
#18
N E Carlozzi, S Goodnight, K B Casaletto, A Goldsmith, R K Heaton, A W K Wong, C M Baum, R Gershon, A W Heinemann, D S Tulsky
Objective: Individuals with spinal cord injury (SCI), traumatic brain injury (TBI), and stroke experience a variety of neurologically related deficits across multiple domains of function. The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIHTB) examines motor, sensation, cognition, and emotional functioning. The purpose of this paper is to establish the validity of the NIHTB in individuals with neurologic conditions. Methods: Community-dwelling individuals with SCI (n = 209), TBI (n = 184), or stroke (n = 211) completed the NIHTB...
March 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28324848/is-level-of-prematurity-a-risk-plasticity-factor-at-three-years-of-age
#19
Kristin Hadfield, Fearghal O'Brien, Aaron Gerow
Children born preterm have poorer outcomes than children born full-term, but the caregiving environment can ameliorate some of these differences. Recent research has proposed that preterm birth may be a plasticity factor, leading to better outcomes for preterm than full-term infants in higher quality environments. This analysis uses data from two waves of an Irish study of children (at 9 months and 3 years of age, n=11,134 children) and their caregivers (n=11,132 mothers, n=9998 fathers) to investigate differences in how caregiving affects social, cognitive, and motor skills between full-term, late preterm, and very preterm children...
March 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28318840/self-reported-sleep-disturbances-associated-with-procedural-learning-impairment-in-adolescents-at-ultra-high-risk-for-psychosis
#20
Jessica R Lunsford-Avery, Derek J Dean, Vijay A Mittal
Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problems with sleep latency, efficiency, and quality were associated with impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep...
March 16, 2017: Schizophrenia Research
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