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https://www.readbyqxmd.com/read/28526882/prediction-of-cognitive-and-motor-outcome-of-preterm-infants-based-on-automatic-quantitative-descriptors-from-neonatal-mr-brain-images
#1
Pim Moeskops, Ivana Išgum, Kristin Keunen, Nathalie H P Claessens, Ingrid C van Haastert, Floris Groenendaal, Linda S de Vries, Max A Viergever, Manon J N L Benders
This study investigates the predictive ability of automatic quantitative brain MRI descriptors for the identification of infants with low cognitive and/or motor outcome at 2-3 years chronological age. MR brain images of 173 patients were acquired at 30 weeks postmenstrual age (PMA) (n = 86) and 40 weeks PMA (n = 153) between 2008 and 2013. Eight tissue volumes and measures of cortical morphology were automatically computed. A support vector machine classifier was employed to identify infants who exhibit low cognitive and/or motor outcome (<85) at 2-3 years chronological age as assessed by the Bayley scales...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526224/neurocognitive-outcomes-at-10-years-of-age-in-extremely-preterm-newborns-with-late-onset-bacteremia
#2
H Reeve Bright, Kikelomo Babata, Elizabeth N Allred, Carmina Erdei, Karl C K Kuban, Robert M Joseph, T Michael O'Shea, Alan Leviton, Olaf Dammann
OBJECTIVE: To evaluate the difference in 10-year neurocognitive outcomes between extremely low gestational age newborns without bacteremia and those with suspected or confirmed late-onset bacteremia. STUDY DESIGN: Neurocognitive function was evaluated at 10 years of age in 889 children born at <28 weeks of gestation and followed from birth. Definite (culture-positive) late-onset bacteremia during postnatal weeks 2-4 was identified in 223 children, and 129 children had suspected bacteremia...
May 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28522659/validation-of-an-mri-brain-injury-and-growth-scoring-system-in-very-preterm-infants-scanned-at-29-to-35-week-postmenstrual-age
#3
J M George, S Fiori, J Fripp, X K Pannek, X J Bursle, X R X Moldrich, X A Guzzetta, X A Coulthard, X R S Ware, X S E Rose, X P B Colditz, X R N Boyd
BACKGROUND AND PURPOSE: The diagnostic and prognostic potential of brain MR imaging before term-equivalent age is limited until valid MR imaging scoring systems are available. This study aimed to validate an MR imaging scoring system of brain injury and impaired growth for use at 29 to 35 weeks postmenstrual age in infants born at <31 weeks gestational age. MATERIALS AND METHODS: Eighty-three infants in a prospective cohort study underwent early 3T MR imaging between 29 and 35 weeks' postmenstrual age (mean, 32(+2) ± 1(+3) weeks; 49 males, born at median gestation of 28(+4) weeks; range, 23(+6)-30(+6) weeks; mean birthweight, 1068 ± 312 g)...
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28517942/cognitive-bias-and-paw-preference-in-the-domestic-dog-canis-familiaris
#4
Deborah L Wells, Peter G Hepper, Adam D S Milligan, Shanis Barnard
Limb use, an indicator of hemispheric functioning, may be a useful predictor of cognitive bias and hence vulnerability to welfare risk. The relationship between cognitive bias and motor asymmetry, however, has been subject to little investigation. This study explored the association between motor asymmetry and cognitive bias in the domestic dog, a species that displays lateral bias in the form of paw preferences and exhibits positive and negative affective states. Thirty pet dogs had their paw preferences assessed using the Kong ball test...
May 18, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28509934/the-role-of-the-prefrontal-cortex-in-freezing-of-gait-in-parkinson-s-disease-insights-from-a-deep-repetitive-transcranial-magnetic-stimulation-exploratory-study
#5
Moria Dagan, Talia Herman, Anat Mirelman, Nir Giladi, Jeffrey M Hausdorff
Freezing of Gait (FOG) is one of the most debilitating gait impairments in Parkinson's disease (PD), leading to increased fall risk and reduced health-related quality of life. The utility of parkinsonian medications is often limited in the case of FOG and it frequently becomes dopamine resistant. Recent studies have suggested that pre-frontal cortex (PFC) dysfunction contributes to FOG; however, most previous findings provide only indirect evidence. To better understand the role of the PFC, we aimed to investigate the impact of high frequency, deep, repetitive transcranial magnetic stimulation (drTMS) of the medial PFC on FOG and its mediators...
May 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28509343/the-influence-of-vascular-risk-factors-on-cognitive-function-in-early-parkinson-s-disease
#6
Maxime Doiron, Mélanie Langlois, Nicolas Dupré, Martine Simard
OBJECTIVES: Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. METHODS: A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1...
May 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28507300/minimum-toe-clearance-probing-the-neural-control-of-locomotion
#7
Tim Killeen, Christopher S Easthope, László Demkó, Linard Filli, Lilla Lőrincz, Michael Linnebank, Armin Curt, Björn Zörner, Marc Bolliger
Minimum toe clearance (MTC) occurs during a highly dynamic phase of the gait cycle and is associated with the highest risk of unintentional contact with obstacles or the ground. Age, cognitive function, attention and visual feedback affect foot clearance but how these factors interact to influence MTC control is not fully understood. We measured MTC in 121 healthy individuals aged 20-80 under four treadmill walking conditions; normal walking, lower visual field restriction and two Stroop colour/word naming tasks of two difficulty levels...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506482/technical-principles-of-direct-bipolar-electrostimulation-for-cortical-and-subcortical-mapping-in-awake-craniotomy
#8
J Pallud, E Mandonnet, R Corns, E Dezamis, E Parraga, M Zanello, G Spena
INTRODUCTION: Intraoperative application of electrical current to the brain is a standard technique during brain surgery for inferring the function of the underlying brain. The purpose of intraoperative functional mapping is to reliably identify cortical areas and subcortical pathways involved in eloquent functions, especially motor, sensory, language and cognitive functions. MATERIAL AND METHODS: The aim of this article is to review the rationale and the electrophysiological principles of the use of direct bipolar electrostimulation for cortical and subcortical mapping under awake conditions...
May 12, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28505243/association-of-dual-task-gait-with-incident-dementia-in-mild-cognitive-impairment-results-from-the-gait-and-brain-study
#9
Manuel M Montero-Odasso, Yanina Sarquis-Adamson, Mark Speechley, Michael J Borrie, Vladimir C Hachinski, Jennie Wells, Patricia M Riccio, Marcelo Schapira, Ervin Sejdic, Richard M Camicioli, Robert Bartha, William E McIlroy, Susan Muir-Hunter
Importance: Gait performance is affected by neurodegeneration in aging and has the potential to be used as a clinical marker for progression from mild cognitive impairment (MCI) to dementia. A dual-task gait test evaluating the cognitive-motor interface may predict dementia progression in older adults with MCI. Objective: To determine whether a dual-task gait test is associated with incident dementia in MCI. Design, Setting, and Participants: The Gait and Brain Study is an ongoing prospective cohort study of community-dwelling older adults that enrolled 112 older adults with MCI...
May 15, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28504524/healthy-aging-is-associated-with-decreased-risk-taking-in-motor-decision-making
#10
Matteo Valsecchi, Jutta Billino, Karl R Gegenfurtner
Healthy aging is associated with changes in both cognitive abilities, including decision-making, and motor control. Previous research has shown that young healthy observers are close to optimal when they perform a motor equivalent of economic decision-making tasks that are known to produce suboptimal decision patterns. We tested both younger (age 20-29) and older (age 60-79) adults in such a task, which involved rapid manual aiming and monetary rewards and punishments contingent on hitting different areas on a touch screen...
May 15, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28503462/predictors-for-depressive-mood-in-geriatric-patients-after-traumatic-brain-injury-a-retrospective-cross-sectional-study
#11
Je Kyung Kim, Na Young Kim, Yong Wook Kim
OBJECTIVE: To identify predictors for depressive mood in geriatric patients after traumatic brain injury (TBI). METHODS: A retrospective review of patients' medical charts was performed in TBI patients who were older than 60 years and referred to the Department of Rehabilitation Medicine at Severance Hospital in 2002-2016. The patients were classified into two groups based on the Geriatric Depression Scale (GDS): non-depressive group (0≤GDS≤16) and depressive group (17≤GDS≤30)...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28495514/neurobehavioral-risks-of-ssris-in-pregnancy-comparing-human-and-animal-data
#12
REVIEW
Asher Ornoy
During the last twenty years, in spite of extensive literature regarding the use of SSRIs in pregnancy, confusion still exists as to possible long-term risks of these drugs on the offspring. Possible negative effects relate to neurodevelopmental outcome and association with Autism Spectrum Disorder (ASD). Most neurodevelopmental follow up studies did not find significant cognitive impairment except from some apparently transient, gross motor delay and slight impairment of language abilities. The literature on the possible association of SSRIs with ASD is inconsistent, and if an association exists it is apparently throughout pregnancy...
May 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28486677/the-effects-of-age-and-hearing-loss-on-dual-task-balance-and-listening
#13
Halina Bruce, Daniel Aponte, Nancy St-Onge, Natalie Phillips, Jean-Pierre Gagné, Karen Z H Li
Objectives: Among older adults (OA), hearing loss is associated with an increased risk for falls. The aim of the present study was to experimentally investigate the cognitive compensation hypothesis, wherein decreased auditory and motor functioning are compensated by the recruitment of cognitive resources. Method: Twenty-nine younger adults (YA), 26 OA, and 32 OA with age-related hearing loss (ARHL) completed a dual-task paradigm consisting of cognitive and balance recovery tasks performed singly and concurrently...
May 9, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28486543/preterm-brain-injury-on-term-equivalent-age-mri-in-relation-to-perinatal-factors-and-neurodevelopmental-outcome-at-two-years
#14
Margaretha J Brouwer, Karina J Kersbergen, Britt J M van Kooij, Manon J N L Benders, Ingrid C van Haastert, Corine Koopman-Esseboom, Jeffrey J Neil, Linda S de Vries, Hiroyuki Kidokoro, Terrie E Inder, Floris Groenendaal
OBJECTIVES: First, to apply a recently extended scoring system for preterm brain injury at term-equivalent age (TEA-)MRI in a regional extremely preterm cohort; second, to identify independent perinatal factors associated with this score; and third, to assess the prognostic value of this TEA-MRI score with respect to early neurodevelopmental outcome. STUDY DESIGN: 239 extremely preterm infants (median gestational age [range] in weeks: 26.6 [24.3-27.9]), admitted to the Wilhelmina Children's Hospital between 2006 and 2012 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28485643/effects-of-line-dancing-on-physical-function-and-perceived-limitation-in-older-adults-with-self-reported-mobility-limitations
#15
Crystal G Bennett, Madeleine E Hackney
INTRODUCTION: Older adults with mobility limitations are at greater risk for aging-related declines in physical function. Line dancing is a popular form of exercise that can be modified, and is thus feasible for older adults with mobility limitations. PURPOSE: The purpose of this study was to assess the effects of 8 weeks of line dancing on balance, muscle strength, lower extremity function, endurance, gait speed, and perceived mobility limitations. METHODS: An experimental design randomly assigned older adults to either an 8-week line dancing or usual care group...
February 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28472425/prodromal-parkinsonism-and-neurodegenerative-risk-stratification-in-rem-sleep-behaviour-disorder
#16
Thomas R Barber, Michael Lawton, Michal Rolinski, Samuel Evetts, Fahd Baig, Claudio Ruffmann, Aimie Gornall, Johannes C Klein, Christine Lo, Gary Dennis, Oliver Bandmann, Timothy Quinnell, Zenobia Zaiwalla, Yoav Ben-Shlomo, Michele Tm Hu
Objectives.: REM sleep behaviour disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical characteristics of RBD and evaluate risk stratification models. Methods.: Clinical assessments were performed in 171 RBD, 296 control and 119 untreated Parkinson's (PD) subjects. Putative risk measures were assessed as predictors of prodromal neurodegeneration and Movement Disorders Society (MDS) criteria for prodromal PD were applied...
May 4, 2017: Sleep
https://www.readbyqxmd.com/read/28471442/an-antenatal-marker-of-neurodevelopmental-outcomes-in-infants-with-congenital-heart-disease
#17
S Siddiqui, W P Fifer, M Ordonez-Retamar, J D Nugent, I A Williams
OBJECTIVE: Prenatal exposures are known to alter fetal neurodevelopment and autonomic control. We aimed to explore the correlation between fetal autonomic activity, measured by fetal heart rate variability, and 18-month developmental outcome in subjects with congenital heart disease. STUDY DESIGN: From 2010 to 2013, 5 fetuses with hypoplastic left heart syndrome, 9 with transposition of the great arteries and 9 with tetralogy of Fallot were included in this prospective cohort study...
May 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28459953/early-clinical-predictors-of-5-year-outcome-after-concussive-blast-traumatic-brain-injury
#18
Christine L Mac Donald, Jason Barber, Mary Jordan, Ann M Johnson, Sureyya Dikmen, Jesse R Fann, Nancy Temkin
Importance: The long-term clinical effects of wartime traumatic brain injuries (TBIs), most of which are mild, remain incompletely described. Current medical disability cost estimates from world conflicts continually surpass projections. Additional information regarding long-term functional trajectory is needed to reduce this extensive public health burden. Objectives: To examine 5-year clinical outcomes leveraging existing clinical data collected at 1 year after injury in the same patients and to identify early risk factors for long-term disability...
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28452420/neurobehavioural-and-cognitive-development-in-infants-born-to-mothers-with-eating-disorders
#19
M Barona, E Taborelli, F Corfield, S Pawlby, A Easter, U Schmidt, J Treasure, N Micali
INTRODUCTION: Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. METHODS: Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy...
April 28, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28447569/a-new-treatment-strategy-for-parkinson-s-disease-through-the-gut-brain-axis-the-glucagon-like-peptide-1-receptor-pathway
#20
Dong Seok Kim, Ho-Il Choi, Yun Wang, Yu Luo, Barry J Hoffer, Nigel H Greig
Molecular communications in the gut-brain axis, between the central nervous system and the gastrointestinal tract, arecritical for maintaining healthy brain function particularly in aging. Epidemiological analyses indicate type 2 diabetes mellitus (T2DM) is a risk factor for neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's diseases (PD) for which aging shows a major correlative association. Common pathophysiological features exist between T2DM, AD and PD, including oxidative stress, inflammation, insulin resistance, abnormal protein processing and cognitive decline, and suggest that effective drugs for T2DM that positively impact the gut-brain axis could provide an effective treatment option for neurodegenerative diseases...
April 26, 2017: Cell Transplantation
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