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Myocardial viability

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https://www.readbyqxmd.com/read/28316034/updates-on-stress-imaging-testing-and-myocardial-viability-with-advanced-imaging-modalities
#1
REVIEW
Sandeep S Hedgire, Michael Osborne, Daniel J Verdini, Brian B Ghoshhajra
Non-invasive stress testing plays a key role in diagnosis and risk stratification in patients with coronary artery disease. Technical advances in CT, MRI, and PET have lead to increased utility of these modalities in myocardial perfusion imaging. The aim of the review is to provide a succinct update on CT, PET, and MRI for myocardial stress perfusion imaging.
April 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28301075/clinical-performance-of-high-resolution-late-gadolinium-enhancement-imaging-with-compressed-sensing
#2
Tamer A Basha, Mehmet Akçakaya, Charlene Liew, Connie W Tsao, Francesca N Delling, Gifty Addae, Long Ngo, Warren J Manning, Reza Nezafat
PURPOSE: To evaluate diagnostic image quality of 3D late gadolinium enhancement (LGE) with high isotropic spatial resolution (∼1.4 mm(3) ) images reconstructed from randomly undersampled k-space using LOw-dimensional-structure Self-learning and Thresholding (LOST). MATERIALS AND METHODS: We prospectively enrolled 270 patients (181 men; 55 ± 14 years) referred for myocardial viability assessment. 3D LGE with isotropic spatial resolution of 1.4 ± 0.1 mm(3) was acquired at 1...
March 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28297585/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#3
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28295592/knockdown-of-long-non-coding-rna-zfas1-protects-cardiomyocytes-against-acute-myocardial-infarction-via-anti-apoptosis-by-regulating-mir-150-crp
#4
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li, Renqiang Yang, Yunde Li, Yingzhang Cheng
BACKGROUND: ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement of ZFAS1 and its regulatory role in AMI. METHODS: In this study, the models of AMI rat and myocardial cell cultured under hypoxia were made. The expression of ZFAS1 and miR-150 of myocardial infarction tissue or cardiac myocytes was determined by quantitative real time PCR. The regulatory role of ZFAS1 on miR-150 was examined by RNA pull down assay...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28289524/assessment-of-stable-coronary-artery-disease-by-cardiovascular-magnetic-resonance-imaging-current-and-emerging-techniques
#5
REVIEW
James R J Foley, Sven Plein, John P Greenwood
Coronary artery disease (CAD) is a leading cause of death and disability worldwide. Cardiovascular magnetic resonance (CMR) is established in clinical practice guidelines with a growing evidence base supporting its use to aid the diagnosis and management of patients with suspected or established CAD. CMR is a multi-parametric imaging modality that yields high spatial resolution images that can be acquired in any plane for the assessment of global and regional cardiac function, myocardial perfusion and viability, tissue characterisation and coronary artery anatomy, all within a single study protocol and without exposure to ionising radiation...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28287478/myocardial-ischemic-postconditioning-promotes-autophagy-against-ischemia-reperfusion-injury-via-the-activation-of-the-nnos-ampk-mtor-pathway
#6
Maojuan Hao, Suhua Zhu, Liang Hu, Hongyi Zhu, Xiaowei Wu, Qingping Li
Autophagy participates in the progression of many diseases, comprising ischemia/ reperfusion (I/R). It is reported that it is involved in the protective mechanism of ischemic postconditioning (IPostC). According to research, neuronal nitric oxide synthase (nNOS) is also involved in the condition of I/R and IPostC. However, the relationship between nNOS, autophagy and IPostC has not been previously investigated. We hypothesize that IPostC promotes autophagy activity against I/R injury partially through nNOS-mediated pathways...
March 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28284430/antioxidant-and-cardioprotective-effects-of-ilex-cornuta-on-myocardial-ischemia-injury
#7
Yan Yuan, Shu Pan, Shi-Lin Yang, Yan-Li Liu, Qiong-Ming Xu
Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxidant and cardioprotective effects of Ilex cornuta root with in vitro and in vivo models. The anti-oxidative effects of the extract of Ilex cornuta root (ICR) were measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging and MTT assays as well as immunoassay...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28280861/a-growing-role-for-the-hippo-signaling-pathway-in-the-heart
#8
REVIEW
Yu Zhang, Dominic P Del Re
Heart disease is a major cause of clinical morbidity and mortality, and a significant health and economic burden worldwide. The loss of functional cardiomyocytes, often a result of myocardial infarction, leads to impaired cardiac output and ultimately heart failure. Therefore, efforts to improve cardiomyocyte viability and stimulate cardiomyocyte proliferation remain attractive therapeutic goals. Originally identified in Drosophila, the Hippo signaling pathway is highly conserved from flies to humans and regulates organ size through modulation of both cell survival and proliferation...
March 10, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28261787/signalling-mechanisms-underlying-doxorubicin-and-nox2-nadph-oxidase-induced-cardiomyopathy-involvement-of-mitofusin-2
#9
Declan McLaughlin, Youyou Zhao, Karla M O'Neill, Kevin S Edgar, Philip D Dunne, Anna M Kearney, David J Grieve, Barbara J McDermott
BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived superoxide reported to play a key role. The aim of this study was to identify novel mechanisms underlying development of cardiac remodelling/dysfunction further to DOX-stimulated Nox2 activation. EXPERIMENTAL APPROACH: Nox2(-/-) and wild-type (WT) littermate mice were administered DOX (12mg/kg over 3 weeks) prior to study at 4 weeks...
March 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28259939/the-role-of-zfp580-a-novel-zinc-finger-protein-in-tgf-mediated-cytoprotection-against-chemical-hypoxia%C3%A2-induced-apoptosis-in-h9c2-cardiac-myocytes
#10
Shi-Yun Mao, Xiang-Yan Meng, Zhong-Wei Xu, Wen-Cheng Zhang, Xiao-Han Jin, Xi Chen, Xin Zhou, Yu-Ming Li, Rui-Cheng Xu
Zing finger protein 580 (ZFP580) is a novel Cys2-His2 zinc-finger transcription factor that has an anti-apoptotic role in myocardial cells. It is involved in the endothelial transforming growth factor‑β1 (TGF‑β1) signal transduction pathway as a mothers against decapentaplegic homolog (Smad)2 binding partner. The aim of the present study was to determine the involvement of ZFP580 in TGF‑β1‑mediated cytoprotection against chemical hypoxia‑induced apoptosis, using H9c2 cardiac myocytes. Hypoxia was chemically induced in H9c2 myocardial cells by exposure to cobalt chloride (CoCl2)...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28250059/netrin-1-restores-cell-injury-and-impaired-angiogenesis-in-vascular-endothelial-cells
#11
Ying Xing, Jingbo Lai, Xiangyang Liu, Nana Zhang, Jie Ming, Hengxin Liu, Xi Zhang
Diabetic foot ulceration (DFU) represents a common vascular complication of diabetes mellitus (DM) with high morbidity and disability resulting from amputation. Netrin-1 level was decreased in type 2 DM patients and has been identified as a protective regulator against diabetes-triggered myocardial infarction and nephropathy. Unfortunately, its role and molecular mechanism in DFU remain poorly elucidated. Here, netrin-1 levels were reduced in DM and DFU patients relative to healthy controls, with netrin-1 levels being lowest in DFU patients...
March 1, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28243129/polydatin-regulates-proliferation-apoptosis-and-autophagy-in-multiple-myeloma-cells-through-mtor-p70s6k-pathway
#12
Baojun Yang, Shunxin Zhao
BACKGROUND: Polydatin (PD) plays an important role in suppressing platelet aggregation, reducing blood lipid, restoring microcirculation and protecting from myocardial ischemia/reperfusion injury and shock. In addition, PD possesses anticancer activity. However, the effect and the mechanism of PD in regulating multiple myeloma (MM) cell survival and death are still unknown. METHODS: Cell proliferation and apoptosis of RPMI 8226 cells, respectively, were analyzed by cell counting kit8 (CCK-8) assay and flow cytometry...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28242588/effects-of-successful-percutaneous-coronary-intervention-of-chronic-total-occlusions-on-myocardial-perfusion-and-left-ventricular-function
#13
Wijnand J Stuijfzand, P Stefan Biesbroek, Pieter G Raijmakers, Roel S Driessen, Stefan P Schumacher, Pepijn van Diemen, Jeffrey van den Berg, Robin Nijveldt, Adriaan A Lammertsma, Simon J Walsh, Colm G Hanratty, James C Spratt, Albert C van Rossum, Alexander Nap, Niels van Royen, Paul Knaapen
AIMS: The aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery. METHODS AND RESULTS: Patients with a documented CTO were prospectively examined for ischemia and viability with H215O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function...
February 28, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28237535/a-small-cohort-omega-3-pufa-supplement-study-implications-of-stratifying-according-to-lipid-membrane-incorporation-in-cardiac-surgical-patients
#14
Wendy T K Ip, Chanchal Chandramouli, Julian A Smith, Peter L McLennan, Salvatore Pepe, Lea M D Delbridge
BACKGROUND: Epidemiological studies and randomised clinical trials (RCTs) report disparate findings in relation to omega-3 polyunsaturated fatty acids (n-3 PUFA) benefit for cardiac patients. With RCTs interpretation is potentially confounded by background n-3 PUFA intake. The goal of this pilot, small cohort, pre-surgical supplementation study was to evaluate postoperative atrial fibrillation (AF) and cardiac molecular expression profiles employing two data analysis approaches - by treatment randomisation and by stratification using measured n-3 PUFA...
February 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28229420/noninvasive-assessment-of-cell-fate-and-biology-in-transplanted-mesenchymal-stem-cells
#15
Federico Franchi, Martin Rodriguez-Porcel
Recently, molecular imaging has become a conditio sine qua non for cell-based regenerative medicine. Developments in molecular imaging techniques, such as reporter gene technology, have increasingly enabled the noninvasive assessment of the fate and biology of cells after cardiovascular applications. In this context, bioluminescence imaging is the most commonly used imaging modality in small animal models of preclinical studies. Here, we present a detailed protocol of a reporter gene imaging approach for monitoring the viability and biology of Mesenchymal Stem Cells transplanted in a mouse model of myocardial ischemia reperfusion injury...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28225183/protective-effects-of-araloside-c-against-myocardial-ischaemia-reperfusion-injury-potential-involvement-of-heat-shock-protein-90
#16
Min Wang, Yu Tian, Yu-Yang Du, Gui-Bo Sun, Xu-Dong Xu, Hai Jiang, Hui-Bo Xu, Xiang-Bao Meng, Jing-Yi Zhang, Shi-Lan Ding, Miao-di Zhang, Ming-Hua Yang, Xiao-Bo Sun
The present study was designed to investigate whether Araloside C, one of the major triterpenoid compounds isolated from Aralia elata known to be cardioprotective, can improve heart function following ischaemia/reperfusion (I/R) injury and elucidate its underlying mechanisms. We observed that Araloside C concentration-dependently improved cardiac function and depressed oxidative stress induced by I/R. Similar protection was confirmed in isolated cardiomyocytes characterized by maintaining Ca(2+) transients and cell shortening against I/R...
February 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28197310/novel-18-f-labeled-1-hydroxyanthraquinone-derivatives-for-necrotic-myocardium-imaging
#17
Ai-Yan Ji, Qiao-Mei Jin, Dong-Jian Zhang, Hua Zhu, Chang Su, Xing-Hua Duan, Li Bian, Zi-Ping Sun, Yi-Cheng Ni, Jian Zhang, Zhi Yang, Zhi-Qi Yin
Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel (18)F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [(18)F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [(18)F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28187739/the-global-cardiovascular-magnetic-resonance-registry-gcmr-of-the-society-for-cardiovascular-magnetic-resonance-scmr-its-goals-rationale-data-infrastructure-and-current-developments
#18
Raymond Y Kwong, Steffen E Petersen, Jeanette Schulz-Menger, Andrew E Arai, Scott E Bingham, Yucheng Chen, Yuna L Choi, Ricardo C Cury, Vanessa M Ferreira, Scott D Flamm, Kevin Steel, W Patricia Bandettini, Edward T Martin, Leelakrishna Nallamshetty, Stefan Neubauer, Subha V Raman, Erik B Schelbert, Uma S Valeti, Jie Jane Cao, Nathaniel Reichek, Alistair A Young, Lyuba Fexon, Misha Pivovarov, Victor A Ferrari, Orlando P Simonetti
BACKGROUND: With multifaceted imaging capabilities, cardiovascular magnetic resonance (CMR) is playing a progressively increasing role in the management of various cardiac conditions. A global registry that harmonizes data from international centers, with participation policies that aim to be open and inclusive of all CMR programs, can support future evidence-based growth in CMR. METHODS: The Global CMR Registry (GCMR) was established in 2013 under the auspices of the Society for Cardiovascular Magnetic Resonance (SCMR)...
January 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28186163/label-free-detection-of-myocardial-ischaemia-in-the-perfused-rat-heart-by-spontaneous-raman-spectroscopy
#19
Suguru Ohira, Hideo Tanaka, Yoshinori Harada, Takeo Minamikawa, Yasuaki Kumamoto, Satoaki Matoba, Hitoshi Yaku, Tetsuro Takamatsu
Raman spectroscopy, which identifies intrinsic molecular constituents, has a potential for determining myocardial viability under label-free conditions. However, its suitability for evaluating myocardial ischaemia is undetermined. Focusing on cytochromes, i.e., representative molecules reflecting mitochondrial activity, we tested whether Raman spectroscopy is applicable for evaluating myocardial ischaemia especially during early ischaemic phase. We obtained spontaneous Raman spectra of the subepicardial myocardium in the Langendorff-perfused rat heart upon 532-nm excitation before and during the "stopped-flow," global ischaemia...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183655/differential-cytotoxicity-and-internalization-of-graphene-family-nanomaterials-in-myocardial-cells
#20
Flavio F Contreras-Torres, Andrés Rodríguez-Galván, Carlos E Guerrero-Beltrán, Erick Martínez-Lorán, Eduardo Vázquez-Garza, Nancy Ornelas-Soto, Gerardo García-Rivas
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which strongly depends on the used material and the studied cell line, is a fundamental task that needs to be performed prior to its use in biomedical applications. Therefore, the toxicological characterization of GO is still ongoing. This study contributes to this, aiming to synthesize and characterize GO particles and thus investigate their toxic effects in myocardial cells...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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