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Myocardial viability

Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
Pushpinder Kanda, Emilio I Alarcon, Tanya Yeuchyk, Sadrine Parent, Robert A de Kemp, Fabio Variola, David Courtman, Duncan J Stewart, Darryl R Davis
Although cocooning explant-derived cardiac stem cells in protective nanogels prior to intramyocardial injection boosts long-term cell retention, the number of EDCs that finally engraft is trivial and unlikely to account for salutary effects on myocardial function and scar size. As such, we investigated the effect of varying the nanogel content within micro-capsules to alter the physical properties of cocoons without influencing cocoon dimensions. Increasing nanogel concentration enhanced cell migration and viability while improving cell-mediated repair of injured myocardium...
April 16, 2018: ACS Nano
Jeroen J Bax, Victoria Delgado
No abstract text is available yet for this article.
April 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Rongchong Huang, Haichen Lv, Kang Yao, Lei Ge, Zhishuai Ye, Huaiyu Ding, Yiqi Zhang, Hao Lu, Zheyong Huang, Shuning Zhang, Yunzeng Zou, Junbo Ge
G-CSF mobilization might be beneficial to ICM, but the relationship between effect/safety and the dosage of G-CSF remains unclear. In this study, 24 pigs were used to build ICM models and were randomized into four groups. Four weeks later, different dosages of G-CSF were given daily by subcutaneous injection for 5 days. Another 4 weeks later, all the animals were sacrificed. Electrocardiography, coronary arteriography, left ventriculography, transthoracic echocardiography, cardiac MRI, and SPECT, histopathologic analysis, and immunohistochemistry techniques were used to evaluate left ventricular function and myocardial infarct size...
April 12, 2018: Scientific Reports
Q Li, L Chang, D M Su, X Ma
OBJECTIVE: To investigate the effects of tetrandrine (Tet) on proliferation and activation of rat cardiac fibroblasts. METHODS: Firstly, the cell counting kit-8 (cck-8) assay was applied to detect the effects of Tet with different concentrations on proliferation of cardiac fibroblasts. Secondly, transforming growth factor (TGF-β)with a concentration of 5 μg/L was used to induce the cardiac fibroblast activation, and Western blot was performed to measure the expression variation of β-catenin, vimentin (Vm), fibronectin (Fn) and smooth muscle α-actin (SMA)...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Paweł S Kaczmarczyk, Paweł Maga, Rafał Niżankowski, Rafał Januszek, Marzena Frołow, Mikołaj Maga, Jolanta Kościelniak, Andrzej Belowski
BACKGROUND: The aim of the current study was to assess the relationship between potential predictors of clinical outcomes after percutaneous transluminal angioplasty (PTA) of peripheral arteries during a one-year follow-up. Indices of endothelial function (EF), arterial pulse waveform analysis (aPWA) and markers of peripheral arteries ischemia were among those mostly examined. METHODS: The study comprised of 72 individuals with PAD who underwent PTA of the peripheral arteries...
April 3, 2018: Cardiology Journal
Nicole Marijanovich, Alexandra Halalau
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a wide range of clinical and serological manifestations. Cardiac disease among patients with SLE is common and can involve the pericardium, myocardium, valves, conduction system, and coronary arteries. We are reporting a case of SLE in a young woman that is unique is unique in that initial symptoms consisted of pericarditis and hemorrhagic tamponade which remained progressive and resistant to aggressive immunosuppressive treatment and led to severe cardiomyopathy (ejection fraction of 25%) and severe (+4) mitral regurgitation...
2018: Case Reports in Rheumatology
Yun Qiu, Yichen Wu, Min Meng, Man Luo, Hongmei Zhao, Hong Sun, Sumin Gao
BACKGROUND: This study explores the protective effects of a hydrogen sulfide donor, morpholin-4-ium 4-methoxyphenyl-morpholino-phosphinodithioate (GYY4137), in the hearts of diabetic mice that had been subjected to myocardial ischemia/reperfusion injury. Diabetes impairs the Akt pathway, in which the Akt protein is dephosphorylated and inactivated by PH domain leucine-rich repeat protein phosphatase-1 (PHLPP-1). However, the function of PHLPP-1 and molecular mechanism that underlies the cardiac protection exerted by GYY4137 remains unknown...
May 2018: Journal of Surgical Research
Jochen von Spiczak, Manoj Mannil, Sebastian Kozerke, Hatem Alkadhi, Robert Manka
BACKGROUND: Since patients with myocardial hypoperfusion due to coronary artery disease (CAD) with preserved viability are known to benefit from revascularization, accurate differentiation of hypoperfusion from scar is desirable. PURPOSE: To develop a framework for 3D fusion of whole-heart dynamic cardiac MR perfusion and late gadolinium enhancement (LGE) to delineate stress-induced myocardial hypoperfusion and scar. STUDY TYPE: Prospective feasibility study...
March 30, 2018: Journal of Magnetic Resonance Imaging: JMRI
Hao Zhou, Yan Yue, Jin Wang, Qiang Ma, Yundai Chen
Melatonin and its metabolites have been demonstrated to modulate the glucose, dyslipidemia and other metabolic disorders. This study aimed to explore a novel mechanism responsible for diabetic cardiomyopathy development, and also validated whether melatonin played a protective role in repairing damaged heart in the diabetes setting. Our data demonstrated that spleen tyrosine kinase (Syk) was activated by chronic high-glucose stimulus and contributed to the development of diabetic cardiomyopathy. However, genetic ablation of Syk or supplementation of melatonin to inhibit Syk activation improved diabetic myocardial function, reduced cardiac fibrosis and preserved cardiomyocytes viability...
March 28, 2018: Cellular Signalling
Francesco Maffessanti, Frits W Prinzen, Giulio Conte, François Regoli, Maria Luce Caputo, Daniel Suerder, Tiziano Moccetti, Francesco Faletra, Rolf Krause, Angelo Auricchio
OBJECTIVES: This study sought to test the accuracy of strain measurements based on anatomo-electromechanical mapping (AEMM) measurements compared with magnetic resonance imaging (MRI) tagging, to evaluate the diagnostic value of AEMM-based strain measurements in the assessment of myocardial viability, and the additional value of AEMM over peak-to-peak local voltages. BACKGROUND: The in vivo identification of viable tissue, evaluation of mechanical contraction, and simultaneous left ventricular activation is currently achieved using multiple complementary techniques...
January 2018: JACC. Clinical Electrophysiology
Christopher T Nguyen, James Dawkins, Xiaoming Bi, Eduardo Marbán, Debiao Li
The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDCEXO ) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDCEXO and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDCEXO group, whereas myocardial fiber architecture and cardiac function were preserved...
February 2018: JACC. Basic to Translational Science
Manuel Barreiro-Pérez, Elena Tundidor-Sanz, Ana Martín-García, Elena Díaz-Peláez, Alberto Íscar-Galán, Soraya Merchán-Gómez, María Gallego-Delgado, Javier Jiménez-Candil, Ignacio Cruz-González, Pedro L Sánchez
Magnetic resonance (MR) is considered the gold standard in the assessment of myocardial morphology, function, perfusion, and viability. However, its main limitation is its scarce availability. In 2014, we installed the first MR scanner exclusively managed by a cardiology department within the publicly-funded Spanish healthcare system with the aim of improving patient-care, training and research in the department. In the time interval analyzed, July 2014 to May 2017, 3422 cardiac MR scans were performed (32minutes used per study; 96% with good quality; 75% with contrast media administration)...
March 26, 2018: Revista Española de Cardiología
Xiuge Gao, Yani Zheng, Lin Peng, Xiangchun Ruan, Hui Ji, Yawei Qiu, Xiaoxiao Liu, Pei Teng, Dawei Guo, Shanxiang Jiang
Maduramicin is one of the most extensively used anticoccidial drugs for the treatment of Eimeria spp. infections. However, overdosage, misuse and drug interactions have resulted in the development of ionophore toxic syndrome. Heart and skeletal muscles have been identified as the main target organs of toxicity. In the present study, primary chicken myocardial cells were isolated to investigate the toxicity and underlying mechanisms of maduramicin. Our results showed that maduramicin causes morphological changes and a decrease in the viability of chicken myocardial cells...
March 23, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Andreas Skyschally, Petra Kleinbongard, Helmut Raphael Lieder, Nilguen Gedik, Leanda Stoian, Georgios Amanakis, Etienne Elbers, Gerd Heusch
Remote ischemic perconditioning during ongoing myocardial ischemia (RPER), reduces infarct size. The signal transduction of RPER's cardioprotection is still largely unknown. Anesthetized pigs were therefore subjected to RPER by 4×5 min/5 min hindlimb ischemia/reperfusion during 60 min coronary occlusion before 3 h reperfusion. Pigs without RPER served as placebo (PLA). The phosphorylation of AKT and ERK (reperfusion injury salvage kinase [RISK] pathway), and STAT3 (survivor activating factor enhancement [SAFE] pathway) in the area at risk was determined by Western blot...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Yong-Lu Pan, Zheng-Yi Han, Shu-Fang He, Wan Yang, Jie Cheng, Ye Zhang, Zhi-Wu Chen
In a previous study using a microRNA (miRNA/miR) microarray assay, we demonstrated that miR-133b-5p was upregulated in response to hypoxic preconditioning (HPC). The present study was designed to investigate the role of the miR‑133b‑5p in HPC‑induced cardioprotection and the underlying mechanisms involving caspase‑8 and caspase‑3 apoptotic signaling. Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured...
March 20, 2018: Molecular Medicine Reports
Guiqiong Huang, Xiaofang Huang, Min Liu, Yue Hua, Bo Deng, Wen Jin, Wen Yan, Zhangbin Tan, Yifen Wu, Bin Liu, Yingchun Zhou
Myocardial cell apoptosis mediated by oxidative stress has previously been identified as a key process in ischemic heart disease. Secoisolariciresinol diglucoside (SDG), a polyphenolic plant lignan primarily found in flaxseed, has been demonstrated to effectively protect myocardial cells from apoptosis. In the present study, the role of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) was investigated in mediating the protective effect of SDG. Findings of the present study revealed that treatment with H2O2 reduced cell viability and induced apoptosis in H9C2 rat cardiomyocytes...
March 13, 2018: International Journal of Molecular Medicine
Shenjie Chen, Bingsheng Yang, Yifei Xu, Yiqing Rong, Yuangang Qiu
Myocardial hypertrophy is often associated with myocardial infarction. Luteolin-7-O-glucoside (LUTG) has the prosperity of preventing cardiomyocyte injury. The current study aimed to explore the potential protective effect of LUTG and its relevant mechanisms in the heart. To establish the cardiac hypertrophy model in vitro, Angiotensin II (Ang II) was used to stimuli H9c2 cells in this study. The CCK‑8 assay showed that LUTG pretreatment improved cell viability of cardiomyocytes co‑treated with Ang II and ischemia/reperfusion...
March 19, 2018: Molecular Medicine Reports
Carol W Chen, Leo L Wang, Samir Zaman, Jon Gordon, Maria F Arisi, Chantel M Venkataraman, Jennifer J Chung, George Hung, Ann C Gaffey, Lynn A Spruce, Hossein Fazelinia, Robert C Gorman, Steven H Seeholzer, Jason A Burdick, Pavan Atluri
Aims: Previous studies have demonstrated improved cardiac function following myocardial infarction (MI) after administration of endothelial progenitor cells (EPCs) into ischemic myocardium. A growing body of literature supports paracrine effectors, including extracellular vesicles (EVs), as the main mediators of the therapeutic benefits of EPCs. The use of paracrine factors is an attractive strategy that harnesses the effects of cell therapy without concerns of cell engraftment or viability...
March 16, 2018: Cardiovascular Research
Adam Vandergriff, Ke Huang, Deliang Shen, Shiqi Hu, Michael Taylor Hensley, Thomas G Caranasos, Li Qian, Ke Cheng
Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies have used intramyocardial injection in order to concentrate exosomes in the infarct. Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targeting peptide, cardiac homing peptide (CHP), to target intravenously-infused exosomes to the infarcted heart. Methods: Exosomes were conjugated with CHP through a DOPE-NHS linker...
2018: Theranostics
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