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Breast carcinoma in situ

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https://www.readbyqxmd.com/read/29666991/frequency-and-characteristics-of-contralateral-breast-abnormalities-following-recall-at-screening-mammography
#1
Joost R C Lameijer, Angela Coolen, Adri C Voogd, Luc J Strobbe, Marieke W J Louwman, Dick Venderink, Vivian C Tjan-Heijnen, Lucien E M Duijm
PURPOSE: To determine the frequency and characteristics of contralateral, non-recalled breast abnormalities following recall at screening mammography. METHODS: We included a series of 130,338 screening mammograms performed between 1 January 2014 and 1 January 2016. During the 1-year follow-up, clinical data were collected for all recalls. Screening outcome was determined for recalled women with or without evaluation of contralateral breast abnormalities. RESULTS: Of 3,995 recalls (recall rate 3...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29666479/reply-to-commentary-on-her2-immunohistochemical-and-fluorescence-in-situ-hybridization-discordances-in-invasive-breast-carcinoma-with-micropapillary-features
#2
Rachel L Stewart, Evin H Gulbahce, Katherine B Geiersbach, Erinn Downs-Kelly
No abstract text is available yet for this article.
April 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29665100/accuracy-of-ultrasound-for-preoperative-assessment-of-tumor-size-in-patients-with-newly-diagnosed-breast-cancer-is-it-affected-by-the-background-parenchymal-echotexture
#3
Kyung Hee Ko, Eun Ju Son, In Wha Kim
OBJECTIVES: To assess the impact of the background parenchymal echotexture on the accuracy of tumor size estimation using breast ultrasound (US). METHODS: A total of 140 women with newly diagnosed invasive breast cancer from January 2014 to December 2015 were enrolled in this study. Two radiologists retrospectively reviewed US images in consensus for background parenchymal echotexture interpretation. The maximum tumor diameter from static images was recorded. Tumor size measurements were considered as having agreement with histologic results if they were within ±5 mm compared to the pathologic size...
April 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29661250/isocitrate-dehydrogenase-1-snail-axis-dysfunction-significantly-correlates-with-breast-cancer-prognosis-and-regulates-cell-invasion-ability
#4
Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger, Kuo-Wang Tsai
BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. METHODS: In this study, the clinical impact of IDH1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay (IHC) of the corresponding tumor-adjacent normal, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) tissues from 309 patients with breast ductal carcinoma...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29650835/-diagnosis-of-a-non-invasive-ductal-carcinoma-assisted-by-long-term-follow-up-of-spontaneous-nipple-discharge-a-case-report
#5
Tomohiro Hirano, Shuhei Suzuki, Keita Adachi, Hitomi Kubota, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai
We report a case of a non-invasive ductal carcinoma revealed on long-term follow-up of spontaneous nipple discharge. The patient, a 36-year-old woman, had noticed spontaneous nipple discharge from both breasts over a 3-year period. Mammography and ultrasonography did not reveal any lesions in the breasts. The nipple discharge from her left breast stopped 36 months after initial clinical assessment. However, the nipple discharges from her right breast transformed into a bloody discharge from a single duct. Ultrasonography showed a tumor, 6mm in diameter, in the upper-outer quadrant of her right breast...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629604/the-assessment-of-her2-gene-status-by-fluorescence-in-situ-hybridization-in-invasive-breast-carcinomas-with-equivocal-her2-immunostaining-experience-from-a-single-institution
#6
Boubacar Efared, Ibrahim S Sidibé, Sana Gamrani, Ihsane El Otmani, Fatimazahra Erregad, Nawal Hammas, Sanae Bennis, Laila Chbani, Hinde El Fatemi
BACKGROUND: A subset of breast carcinomas harbors overexpression of the human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) should be performed in breast carcinomas with equivocal HER2 immunostaining (immunohistochemistry [IHC] HER2 2+). The aim of our study is to investigate clinicopathologic factors associated with HER2 status in breast invasive carcinomas with IHC HER2 2+ through FISH analysis. METHODS: This is a retrospective study including the FISH analysis of 111 patients with invasive breast carcinomas with equivocal HER2 immunostaining...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29628978/basic-findings-regarding-breast-cancer-in-korea-in-2015-data-from-a-breast-cancer-registry
#7
REVIEW
Sang Yull Kang, Yoo Seok Kim, Zisun Kim, Hyun-Yul Kim, Se Kyung Lee, Kyu-Won Jung, Hyun Jo Youn
The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea has steadily increased since the nationwide database was established, and the crude rate and age-standardized rate including that of carcinoma in situ , were 88...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29623676/cost-effectiveness-of-the-breconda-decision-aid-for-women-with-breast-cancer-results-from-a-randomized-controlled-trial
#8
Bonny Parkinson, Kerry A Sherman, Paul Brown, Laura-Kate E Shaw, John Boyages, Linda D Cameron, Elisabeth Elder, Thomas Lam
OBJECTIVE: To report on the cost-effectiveness of BRECONDA (Breast RECONstruction Decision Aid), a web-based decision aid to facilitate decisions regarding breast reconstruction surgery, with usual care for women with breast cancer. METHODS: The economic evaluation was conducted alongside a randomized controlled trial. Women diagnosed with breast cancer or ductal carcinoma in situ and eligible for breast reconstruction following mastectomy were randomized to access BRECONDA for 6 months + usual care (n = 106) or usual care (n = 116) and were assessed at baseline preintervention, and then 1-month and 6-months post-randomization...
April 5, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29621362/long-term-accuracy-of-breast-cancer-risk-assessment-combining-classic-risk-factors-and-breast-density
#9
Adam R Brentnall, Jack Cuzick, Diana S M Buist, Erin J Aiello Bowles
Importance: Accurate long-term breast cancer risk assessment for women attending routine screening could help reduce the disease burden and intervention-associated harms by personalizing screening recommendations and preventive interventions. Objective: To report the accuracy of risk assessment for breast cancer during a period of 19 years. Design, Setting, and Participants: This cohort study of the Kaiser Permanente Washington breast imaging registry included women without previous breast cancer, aged 40 to 73 years, who attended screening from January 1, 1996, through December 31, 2013...
April 5, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29619758/assessing-residual-cancer-cells-using-mri-and-us-after-preoperative-chemotherapy-in-primary-breast-cancer-to-omit-surgery
#10
Madoka Iwase, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Junko Ishiguro, Haruru Kotani, Naomi Gondo, Yayoi Adachi, Ayumi Kataoka, Sakura Onishi, Kayoko Sugino, Hiroji Iwata
BACKGROUND: Enhanced magnetic resonance imaging (MRI) and ultrasonography (US) are used to assess residual lesions after preoperative chemotherapy before surgery. However, residual lesion assessments based on preoperative imaging often differ from postoperative pathologic diagnoses. We retrospectively reviewed the accuracy of preoperative residual lesion assessments, including ductal carcinoma in situ (DCIS) cases to find criteria for cases in which surgery can be omitted. METHODS: We reviewed 201 patients who received preoperative chemotherapy and surgery in our hospital from January 2013 to November 2016...
April 4, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29619057/accelerated-partial-breast-irradiation-in-a-single-18-gy-fraction-with-high-dose-rate-brachytherapy-preliminary-results
#11
Javier Anchuelo Latorre, Piedad Galdós, Lucía Alonso Buznego, Ana García Blanco, Juan Cardenal, María Ferri, Iván Díaz de Cerio, Elisabet Arrojo, Nicolás Sierrasesúmaga, Mónica González Noriega, Ana De Juan Ferré, Rosa Fabregat, Samuel Ruíz, Pedro J Prada
Purpose: To evaluate the feasibility of acute and chronic toxicity in patients suitable for accelerated partial breast irradiation (APBI) in a single 18 Gy fraction with multicatheter high-dose-rate (HDR) brachytherapy, as well as cosmetic and oncological outcomes. Material and methods: Between September 2014 and March 2016, twenty consecutive patients with low-risk invasive and ductal carcinoma in situ were treated with interstitial multicatheter HDR brachytherapy in a single 18 Gy fraction...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#12
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29602724/relationship-between-background-parenchymal-enhancement-on-high-risk-screening-mri-and-future-breast-cancer-risk
#13
Lars J Grimm, Ashirbani Saha, Sujata V Ghate, Connie Kim, Mary Scott Soo, Sora C Yoon, Maciej A Mazurowski
RATIONALE AND OBJECTIVES: To determine if background parenchymal enhancement (BPE) on screening breast magnetic resonance imaging (MRI) in high-risk women correlates with future cancer. MATERIALS AND METHODS: All screening breast MRIs (n = 1039) in high-risk women at our institution from August 1, 2004, to July 30, 2013, were identified. Sixty-one patients who subsequently developed breast cancer were matched 1:2 by age and high-risk indication with patients who did not develop breast cancer (n = 122)...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29599829/microrna-10b-expression-and-its-correlation-with-molecular-subtypes-of-early-invasive-ductal-carcinoma
#14
Chenming Guo, Minggang Fu, Yilamu Dilimina, Sha Liu, Liying Guo
The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, progesterone receptor (PR) and human epidermal growth factor receptor-2 (Her-2). The positive expression rate of miR-10b in patients with early invasive ductal carcinoma with ER-α (+) or PR (+) was decreased compared with ER-α (-) or PR (-) patients (P<0...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29595316/double-equivocal-her2-invasive-breast-carcinomas-institutional-experience-and-review-of-literature
#15
Brannan B Griffin, Jennifer L Pincus, Kalliopi P Siziopikou, Luis Z Blanco
Context HER2 status is a prognostic factor and therapeutic target in invasive breast carcinomas. Reflex testing using an alternate method is recommended on equivocal cases via immunohistochemistry or fluorescence in situ hybridization (FISH). Therapeutic dilemmas arise when both tests are equivocal. The standard chromosome 17 centromere reference probe (CEP17) is in close proximity to the HER2 locus and may be coamplified, leading to equivocal results. Alternate chromosome 17 reference probes may aid in establishing the true HER2 status...
March 29, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29594352/analysis-of-membranous-ki-67-staining-in-breast-cancer-and-surrounding-breast-epithelium
#16
Gábor Cserni
Membranous Ki-67 staining with the MIB-1 antibody has been described in hyalinising trabecular adenomas of the thyroid and sclerosing haemangiomas of the lung. Its relatively rare occurrence in breast tumours has also been documented. The aim of the present study was to assess the rate of any membranous MIB-1 staining in breast specimens. The staining was performed at room temperature with 1:100 dilution of the antibody. One hundred four core needle biopsies and 41 operative specimens were analysed. Membranous staining was noted in 36/144 invasive carcinomas, 20/42 in situ carcinomas and 46/99 cases of peritumoural benign/normal breast epithelium...
March 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29593431/prognostic-value-of-ductal-carcinoma-in-situ-component-in-invasive-ductal-carcinoma-of-the-breast-a-surveillance-epidemiology-and-end-results-database-analysis
#17
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Zhen-Yu He
Background: The prognostic implication of concomitant ductal carcinoma in situ (DCIS) in invasive ductal carcinoma (IDC) remains controversial. Our objective was to investigate whether concomitant DCIS affects survival outcomes in patients with IDC. Materials and methods: Patients with nonmetastatic breast cancer who underwent surgery in 2010-2014 were included from the Surveillance, Epidemiology, and End Results program. Statistical analyses were conducted using χ 2 test, linear-by-linear association, one-way analysis of variance, Kaplan-Meier method, Cox proportional hazards regression model, and propensity score matching (PSM)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29590747/collagenous-spherulosis-associated-with-lobular-carcinoma-in-situ-of-the-breast-two-case-reports
#18
Ga-Eon Kim, Nah Ihm Kim, Ji Shin Lee, Min Ho Park
Collagenous spherulosis (CS) of the breast is a distinctive disease, and is characterized by myoepithelial and epithelial proliferation of nodules in the eosinophilic or basophilic basement membrane enclosed in spherical spaces. CS is rare, but frequently occurs in association with other benign proliferative lesions of the breast. CS is also associated with lobular carcinoma in situ (LCIS). Here, we report two cases of CS associated with LCIS of the breast. Two patients presented with nodules on ultrasound imaging...
March 29, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29589680/dcis-management-in-the-modern-era
#19
Ayesha Khan, Dorin Dumitru, Giuseppe Catanuto, Nicola Rocco, Maurizio B Nava, John Benson
Ductal carcinoma in situ (DCIS) has been the subject of much controversy since the advent of population based breast screening programmes. An increasing number of asymptomatic women are being diagnosed with this condition and there is uncertainty over the best treatment algorithm for this condition if treatment is to be considered at all. Different subtypes of DCIS show innate differences in developmental pathways and biological behaviour. This is not only determined by pathological subtypes but there is increasing understanding of molecular biomarkers related to DCIS progression...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29582675/feasibility-of-the-less-is-more-approach-in-treating-low-risk-ductal-carcinoma-in-situ-diagnosed-on-core-needle-biopsy-ten-year-review-of-ductal-carcinoma-in-situ-upgraded-to-invasion-at-surgery
#20
Mirna B Podoll, Emily S Reisenbichler, Lania Roland, Andrew Bruner, Sarah Mizuguchi, Mary Ann G Sanders
CONTEXT: - Ductal carcinoma in situ (DCIS) represents 20% of screen-detected breast cancers. The likelihood that certain types of DCIS are slow growing and may never progress to invasion suggests that our current standards of treating DCIS could result in overtreatment. The LORIS (LOw RISk DCIS) and LORD (LOw Risk DCIS) trials address these concerns by randomizing patients with low-risk DCIS to either active surveillance or conventional treatment. OBJECTIVE: - To determine the upgrade rate of DCIS diagnosed on core needle biopsy to invasive carcinoma at surgery and to evaluate the safety of managing low-risk DCIS with surveillance alone, by characterizing the pathologic and clinical features of upgraded cases and applying criteria of the LORD and LORIS trials to these cases...
March 27, 2018: Archives of Pathology & Laboratory Medicine
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