keyword
MENU ▼
Read by QxMD icon Read
search

Breast carcinoma in situ

keyword
https://www.readbyqxmd.com/read/29222935/risk-factors-for-positive-resection-margins-of-breast-cancer-tumorectomy-specimen-following-breast-conserving-surgery
#1
Niko Heiss, Valentin Rousson, Assia Ifticene-Treboux, Hans-Anton Lehr, Jean-François Delaloye
Background The aim of the study was to identify risk factors for positive surgical margins in breast-conserving surgery for breast cancer and to evaluate the influence of surgical experience in obtaining complete resection. Methods All lumpectomies for invasive breast carcinoma and ductal carcinoma in situ (DCIS) between April 2008 and March 2010 were selected from the database of a single institution. Re-excision rates for positive margins as well as patient and histopathologic tumor characteristics were analyzed...
December 9, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29221896/correlative-imaging-reveals-physiochemical-heterogeneity-of-microcalcifications-in-human-breast-carcinomas
#2
Jennie A M R Kunitake, Siyoung Choi, Kayla X Nguyen, Meredith M Lee, Frank He, Daniel Sudilovsky, Patrick G Morris, Maxine S Jochelson, Clifford A Hudis, David A Muller, Peter Fratzl, Claudia Fischbach, Admir Masic, Lara A Estroff
Microcalcifications (MCs) are routinely used to detect breast cancer in mammography. Little is known, however, about their materials properties and associated organic matrix, or their correlation to breast cancer prognosis. We combine histopathology, Raman microscopy, and electron microscopy to image MCs within snap-frozen human breast tissue and generate micron-scale resolution correlative maps of crystalline phase, trace metals, particle morphology, and organic matrix chemical signatures within high grade ductal carcinoma in situ (DCIS) and invasive cancer...
December 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29214373/utilization-of-breast-cancer-screening-with-magnetic-resonance-imaging-in-community-practice
#3
Deirdre A Hill, Jennifer S Haas, Robert Wellman, Rebecca A Hubbard, Christoph I Lee, Jennifer Alford-Teaster, Karen J Wernli, Louise M Henderson, Natasha K Stout, Anna N A Tosteson, Karla Kerlikowske, Tracy Onega
BACKGROUND: Breast cancer screening with magnetic resonance imaging (MRI) may be a useful adjunct to screening mammography in high-risk women, but MRI uptake may be increasing rapidly among low- and average-risk women for whom benefits are unestablished. Comparatively little is known about use of screening MRI in community practice. OBJECTIVE: To assess relative utilization of MRI among women who do and do not meet professional society guidelines for supplemental screening, and describe utilization according to breast cancer risk indications...
December 6, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29214365/profiling-differential-microrna-expression-between-in-situ-infiltrative-and-lympho-vascular-space-invasive-breast-cancer-a-pilot-study
#4
Patsy S Soon, Pamela J Provan, Edward Kim, Nirmala Pathmanathan, Dinny Graham, Christine L Clarke, Rosemary L Balleine
Ductal carcinoma in situ (DCIS), invasive breast cancer (IBC) and lympho-vascular invasion (LVI) represent distinct stages in breast cancer progression with different clinical implications. Altered microRNA (miRNA) expression may play a role in mediating the progression of DCIS to IBC and LVI. The aim of this pilot study was to investigate whether differential miRNA expression could play a role in breast cancer progression. Cancer cells from DCIS, IBC and LVI were microdissected from formalin fixed paraffin embedded (FFPE) tissue of five breast cancer samples...
December 6, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29214316/association-between-hospital-financial-distress-and-immediate-breast-reconstruction-surgery-after-mastectomy-among-women-with-ductal-carcinoma-in-situ
#5
Catherine A Richards, Andrew G Rundle, Jason D Wright, Dawn L Hershman
Importance: Hospital financial distress (HFD) is a state in which a hospital is at risk of closure because of its financial condition. Hospital financial distress may reduce the services a hospital can offer, particularly unprofitable ones. Few studies have assessed the association of HFD with quality of care. Objective: To examine the association between HFD and receipt of immediate breast reconstruction surgery after mastectomy among women diagnosed with ductal carcinoma in situ (DCIS)...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29212475/implementation-of-shared-decision-making-in-oncology-development-and-pilot-study-of-a-nurse-led-decision-coaching-programme-for-women-with-ductal-carcinoma-in-situ
#6
Birte Berger-Höger, Katrin Liethmann, Ingrid Mühlhauser, Anke Steckelberg
BACKGROUND: To implement informed shared decision-making (ISDM) in breast care centres, we developed and piloted an inter-professional complex intervention. METHODS: We developed an intervention consisting of three components: an evidence-based patient decision aid (DA) for women with ductal carcinoma in situ, a decision-coaching led by specialised nurses (breast care nurses and oncology nurses) and structured physician encounters. In order to enable professionals to gain ISDM competencies, we developed and tested a curriculum-based training programme for specialised nurses and a workshop for physicians...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29207971/comparison-of-the-association-of-mammographic-density-and-clinical-factors-with-ductal-carcinoma-in-situ-versus-invasive-ductal-breast-cancer-in-korean-women
#7
Hyeonyoung Ko, Jinyoung Shin, Jeong Eon Lee, Seok Jin Nam, Tuong Linh Nguyen, John Llewelyn Hopper, Yun-Mi Song
BACKGROUND: In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal breast cancer (IDC), with inconsistent findings regarding the difference in risk factors between DCIS and IDC. METHODS: We enrolled 472 women with IDC and 90 women with DCIS and 1088 controls matching for age and menopausal status. Information on risk factors was collected through self-administered questionnaire...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29203614/copy-number-profiling-of-oncogenes-in-ductal-carcinoma-in-situ-of-the-male-breast
#8
Marijn Annette Vermeulen, Shusma Doebar, Carolien van Deurzen, John Martens, Paul J van Diest, Cathy B Moelans
Characterizing male breast cancer (BC) and unraveling male breast carcinogenesis is challenging because of the rarity of this disease. We investigated copy number status of 22 BC related genes in 18 cases of pure ductal carcinoma in situ (DCIS) and in 49 cases of invasive carcinoma (IC) with adjacent DCIS (DCIS-AIC) in males using multiplex ligation-dependent probe amplification (MLPA). Results were compared to female BC and correlated with survival. Overall, copy number ratio and aberration frequency including all 22 genes showed no significant difference between the 3 groups...
December 4, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29202946/ductal-carcinoma-in-situ-of-the-breast
#9
Lori A Erickson
No abstract text is available yet for this article.
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29197112/invasion-in-breast-lesions-the-role-of-the-epithelial-stroma-barrier
#10
REVIEW
Emad A Rakha, Islam Miligy, Kylie L Gorringe, Michael S Toss, Andrew R Green, Stephen B Fox, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Thomas Decker, Anne Vincent-Salomon, David J Dabbs, Maria P Foschini, Filipa Moreno, Yang Wentao, Felipe C Geyer, Jorge S Reis-Filho, Sarah E Pinder, Sunil R Lakhani, Ian O Ellis
Despite the significant biological, behavioural and management differences between ductal carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many morphological and molecular similarities. Differentiation of these two different lesions in breast pathological diagnosis is typically based on the presence of an intact barrier between the malignant epithelial cells and stroma, namely the myoepithelial cell (MEC) layer and surrounding basement membrane (BM). Despite being robust diagnostic criteria, the identification of MECs and BM to differentiate in situ from invasive carcinoma is not always straightforward...
December 2, 2017: Histopathology
https://www.readbyqxmd.com/read/29193395/androgen-and-oestrogen-receptors-as-potential-prognostic-markers-for-patients-with-ductal-carcinoma-in%C3%A2-situ-treated-with-surgery-and-radiotherapy
#11
Sara Ravaioli, Maria Maddalena Tumedei, Flavia Foca, Roberta Maltoni, Andrea Rocca, Ilaria Massa, Elisabetta Pietri, Sara Bravaccini
Ductal carcinoma in situ (DCIS) is a heterogeneous disease that has been investigated less extensively than invasive breast cancer. Women with DCIS are mainly treated with conservative surgery almost exclusively followed by radiotherapy. However, as radiation treatment is not always effective, the search for biomarkers capable of identifying DCIS lesions that could progress to invasive cancer is ongoing. Although conventional biomarkers have been thoroughly studied in invasive tumours, little is known about the role played by androgen receptor (AR), widely expressed in DCIS...
November 28, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29191685/breast-mri-as-a-problem-solving-study-in-the-evaluation-of-bi-rads-categories-3-and-4-microcalcifications-is-it-worth-performing
#12
Akiko Shimauchi, Youichi Machida, Ichiro Maeda, Eisuke Fukuma, Kazuei Hoshi, Mitsuhiro Tozaki
RATIONALE AND OBJECTIVES: We aimed to investigate the utility of problem-solving breast magnetic resonance imaging (MRI) for mammographic Breast Imaging Reporting and Data System (BI-RADS) categories 3 and 4 microcalcifications. MATERIALS AND METHODS: Between January 1, 2010 and December 31, 2011, 138 women with 146 areas of categories 3 and 4 microcalcifications without sonographic correlates underwent breast MRI and had a stereotactic core biopsy using an 11-gauge needle or follow-up at least for 24 months...
November 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29185399/negative-predictive-value-of-ultrasound-in-predicting-tumor-free-margins-in-specimen-sonography
#13
Saira Naz, Saima Hafeez, Zainab Hussain, Kiran Hilal
OBJECTIVE: To evaluate the success of ultrasound in post-excision specimen visualization, and negative predictive value of ultrasound for estimation of tumor-free margins using histopathology as the gold standard. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital, Karachi, Pakistan, from May 2010 till January 2013. METHODOLOGY: Sonography of all breast nodules was done before and after exicision by two female radiologists with at least five years clinical experience...
December 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29185118/comparative-effectiveness-of-incorporating-a-hypothetical-dcis-prognostic-marker-into-breast-cancer-screening
#14
Amy Trentham-Dietz, Mehmet Ali Ergun, Oguzhan Alagoz, Natasha K Stout, Ronald E Gangnon, John M Hampton, Kim Dittus, Ted A James, Pamela M Vacek, Sally D Herschorn, Elizabeth S Burnside, Anna N A Tosteson, Donald L Weaver, Brian L Sprague
PURPOSE: Due to limitations in the ability to identify non-progressive disease, ductal carcinoma in situ (DCIS) is usually managed similarly to localized invasive breast cancer. We used simulation modeling to evaluate the potential impact of a hypothetical test that identifies non-progressive DCIS. METHODS: A discrete-event model simulated a cohort of U.S. women undergoing digital screening mammography. All women diagnosed with DCIS underwent the hypothetical DCIS prognostic test...
November 28, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29183534/papillary-breast-lesions-association-with-malignancy-and-upgrade-rates-on-surgical-excision
#15
Hanh-Tam Tran, Asma Mursleen, Sahar Mirpour, Omar Ghanem, Maen J Farha
Intraductal papilloma falls under the category of benign breast mass. However, recent studies show that it can harbor occult carcinoma. The management of benign intraductal papilloma remains controversial because of its nonspecific radiologic and histological findings, as well as its association with surrounding malignant pathology. The purpose of this study is to investigate upgrade rates of a benign intraductal papilloma on surgical excision and the need for surgical excision of papillary lesions diagnosed at core needle biopsy...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29181099/breast-cancers-with-egfr-and-her2-co-amplification-favor-distant-metastasis-and-poor-clinical-outcome
#16
Peng Guo, Tianjie Pu, Shinan Chen, Yan Qiu, Xiaorong Zhong, Hong Zheng, Lina Chen, Hong Bu, Feng Ye
ErbB signaling serves essential roles in invasive ductal carcinoma (IDC). The aim of the present study was to assess gene amplification in ErbB family members in IDC with clinical implications. Quantitative polymerase chain reaction and fluorescence in situ hybridization were performed on formalin-fixed paraffin-embedded tumor samples for gene amplification detection. The clinical and histopathological characteristics, as well as the prognostic significance, were analyzed. Among the 119 IDC patients evaluated, epidermal growth factor receptor [EGFR; also known as human epidermal growth factor receptor (HER)1], HER2, HER3 and HER4 gene amplification was observed in 30 (25...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29180760/detectability-of-breast-tumor-by-a-hand-held-impulse-radar-detector-performance-evaluation-and-pilot-clinical-study
#17
Hang Song, Shinsuke Sasada, Takayuki Kadoya, Morihito Okada, Koji Arihiro, Xia Xiao, Takamaro Kikkawa
In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering the ultrawideband width from 3.1 to 10.6 GHz, which enable the generation and transmission of Gaussian monocycle pulse (GMP) with the pulse width of 160 ps and single port eight throw (SP8T) switching matrices for controlling the combination of 4 × 4 cross-shaped dome antenna array...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179906/diagnostic-challenges-in-papillary-lesions-of-the-breast
#18
REVIEW
Emad A Rakha, Ian O Ellis
Papillary lesions of the breast comprise a heterogeneous group of diseases ranging from benign and atypical lesions to malignant tumours including non-invasive and invasive entities. Although diagnosis of papillary lesions featuring typical histological features is straightforward, a proportion shows overlapping features, posing diagnostic challenges. In addition to being uncommon, the excellent behaviour of papillary tumours reduces the distinguishing value of individual histological features and increases the subjectivity of interpretation of various diagnostic features...
November 24, 2017: Pathology
https://www.readbyqxmd.com/read/29178691/-analysis-of-positive-margins-risk-factors-and-long-term-recurrence-in-the-conservative-treatment-of-breast-cancer
#19
S Barant, J C Noël, P Simon
INTRODUCTION: breast conserving therapy remains the first choice in breast cancer care for the early stages. Adequate surgical margins are essential to reduce the risk of locoregional recurrence. This study aims to identify risk factors of positive margins and locoregional recurrence. MATERIALS AND METHODS: 437 patients who underwent a lumpectomy for invasive breast carcinoma or ductal carcinoma in situ have been included. Age, surgical margins, size, type, grade and number of tumor foci, the presence of ductal carcinoma in situ, lymph node status, expression of hormone receptors and HER-2 gene were assessed as risk factors for positive margins and locoregional recurrence...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29178258/feasibility-analysis-of-early-temporal-kinetics-as-a-surrogate-marker-for-breast-tumor-type-grade-and-aggressiveness
#20
Laura Heacock, Alana A Lewin, Yiming Gao, James S Babb, Samantha L Heller, Amy N Melsaether, Neeti Bagadiya, Sungheon G Kim, Linda Moy
BACKGROUND: Screening breast MRI has been shown to preferentially detect high-grade ductal carcinoma in situ (DCIS) and invasive carcinoma, likely due to increased angiogenesis resulting in early initial uptake of contrast. As interest grows in abbreviated screening breast MRI (AB-MRI), markers of early contrast washin that can predict tumor grade and potential aggressiveness are of clinical interest. PURPOSE: To evaluate the feasibility of using the initial enhancement ratio (IER) as a surrogate marker for tumor grade, hormone receptor status, and prognostic markers, as an initial step to being incorporated into AB-MRI...
November 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
keyword
keyword
43940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"