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https://www.readbyqxmd.com/read/29164969/accuracy-of-self-reported-family-history-of-cancer-mutation-status-and-tumor-characteristics-in-patients-with-early-onset-breast-cancer
#1
Annelie Augustinsson, Carolina Ellberg, Ulf Kristoffersson, Åke Borg, Håkan Olsson
BACKGROUND: The main objectives of this study were to evaluate the concordance between self-reported and registry-reported information regarding family history of breast cancer (BC), ovarian cancer (OvC) and other types of cancer in first-degree relatives of patients with early onset BC, and to determine the frequency of mutation carriers and non-mutation carriers. The secondary objective was to describe tumor characteristics for each mutation group. MATERIAL AND METHODS: Between 1993 and 2013, 231 women who were ≤35 years old when diagnosed with BC were registered at the Oncogenetic Clinic at Skåne University Hospital in Lund, Sweden...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29162038/a-qualitative-study-on-singaporean-women-s-views-towards-breast-cancer-screening-and-single-nucleotide-polymorphisms-snps-gene-testing-to-guide-personalised-screening-strategies
#2
Xin Yi Wong, Kok Joon Chong, Janine A van Til, Hwee Lin Wee
BACKGROUND: Breast cancer is the top cancer by incidence and mortality in Singaporean women. Mammography is by far its best screening tool, but current recommended age and interval may not yield the most benefit. Recent studies have demonstrated the potential of single nucleotide polymorphisms (SNPs) to improve discriminatory accuracy of breast cancer risk assessment models. This study was conducted to understand Singaporean women's views towards breast cancer screening and SNPs gene testing to guide personalised screening strategies...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29145313/the-importance-of-family-caregiving-to-achieving-palliative-care-at-home-a-case-report-of-end-of-life-breast-cancer-in-an-area-struck-by-the-2011-fukushima-nuclear-crisis-a-case-report
#3
Akihiko Ozaki, Masaharu Tsubokura, Claire Leppold, Toyoaki Sawano, Manabu Tsukada, Tsuyoshi Nemoto, Kazuhiro Kosugi, Yoshitaka Nishikawa, Shigeaki Kato, Hiromichi Ohira
RATIONALE: The primary setting of palliative care has shifted from inpatient care to patients' residences. Family caregiving is essential for patients with life-limiting illnesses to receive palliative care at home, however little information is available regarding potential interventions to achieve palliative homecare for those without sufficient support from family members in various settings, including disasters. PATIENT CONCERNS: In March 2011, Fukushima, Japan experienced an earthquake, tsunami and nuclear disaster...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143255/pcb-exposure-and-potential-future-cancer-incidence-in-slovak-children-an-assessment-from-molecular-finger-printing-by-ingenuity-pathway-analysis-ipa%C3%A2-derived-from-experimental-and-epidemiological-investigations
#4
Somiranjan Ghosh, Christopher A Loffredo, Partha S Mitra, Tomas Trnovec, Lubica Palkovicova Murinova, Eva Sovcikova, Eric P Hoffman, Kepher H Makambi, Sisir K Dutta
The risk of cancer due to PCB exposure in humans is highly debated. In eastern Slovakia, high exposure of the population to organochlorines (especially PCBs) was associated with various disease and disorder pathways, viz., endocrine disruption, metabolic disorder & diabetes, and cancer, thereby disturbing several cellular processes, including protein synthesis, stress response, and apoptosis. We have evaluated a Slovak cohort (45-month children, at lower and higher levels of PCB exposure from the environment) for disease and disorder development to develop early disease cancer biomarkers that could shed new light on possible mechanisms for the genesis of cancers under such chemical exposures, and identify potential avenues for prevention...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29139590/breast-density-in-screening-mammography-in-indian-population-is-it-different-from-western-population
#5
Tulika Singh, Niranjan Khandelwal, Veenu Singla, Dileep Kumar, Madhu Gupta, Gurpreet Singh, Amanjit Bal
Mammography is the only method presently considered appropriate for mass screening of breast cancer. However, higher breast density was strongly associated with lower mammographic sensitivity. Breast density is also identified as independent and strongest risk factors for breast cancer. Studies have shown women with high breast density have four to six times increased risk of breast cancer as compare to women with fatty breast. It varies between different age group it generally decreases with increasing age in postmenopausal women and it can be different in different ethnic groups and people from different geographical areas...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29111259/cancer-incidence-and-mortality-among-young-adults-aged-20-39-years-worldwide-in-2012-a-population-based-study
#6
Miranda M Fidler, Sumit Gupta, Isabelle Soerjomataram, Jacques Ferlay, Eva Steliarova-Foucher, Freddie Bray
BACKGROUND: To date, the burden of cancer among young adults has rarely been studied in depth. Our aim was to describe the scale and profile of cancer incidence and mortality worldwide among 20-39 year-olds, highlighting major patterns by age, sex, development level, and geographical region. METHODS: We did a population-based study to quantify the burden of young adult cancers worldwide. We defined young adult cancers as those occurring between the ages of 20 and 39 years because these individuals will have passed puberty and adolescence, but not yet experienced the effects of hormonal decline, immune response deterioration, or organ dysfunction associated with chronic health conditions...
October 27, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29103479/is-breast-magnetic-resonance-imaging-mri-useful-for-diagnosis-of-additional-sites-of-disease-in-patients-recently-diagnosed-with-pure-ductal-carcinoma-in-situ-dcis
#7
A P Benveniste, T Ortiz-Perez, L O Ebuoma, K A Sepulveda, F J Severs, A Roark, T Wang, E L Sedgwick
PURPOSE: To determine if breast MRI is useful for detecting additional or invasive sites of disease in patients initially diagnosed with pure DCIS. MATERIALS AND METHODS: A retrospective review of women diagnosed with pure DCIS who underwent a breast MRI for evaluation of extent of disease was performed at a single institution from January 2013 to April 2015. Data analysis included imaging (mammography, ultrasound and MRI) and pathology characteristics (histology and biomarker status) of the primary DCIS as well as descriptors for the additional sites of disease incidentally found by breast MRI...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29099727/supplemental-computational-phantoms-to-estimate-out-of-field-absorbed-dose-in-photon-radiotherapy
#8
Kyle Joseph Gallagher, Jaad Tannous, Racile Nabha, Joelle Ann Feghali, Zeina Ayoub, Wassim T Jalbout, Bassem Youssef, Phillip J Taddei
The purpose of this study was to develop a straightforward method of supplementing patient anatomy and estimating out-of-field absorbed dose for a cohort of pediatric radiotherapy patients with limited recorded anatomy. A cohort of nine children, aged 2 to 14 years, who received three-dimensional conformal radiotherapy for low grade localized brain tumors (LBTs), were randomly selected for this study. The extents of these patients' computed tomography simulation image sets were cranial only. To approximate their missing anatomy, we supplemented the LBT patients' image sets with computed tomography images of patients in a previous study with larger extents of matched sex, height, and mass and for whom contours of organs at risk for radiogenic cancer had already been delineated...
November 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29095129/the-experience-of-fatigue-in-breast-cancer-patients-1-12-month-post-chemotherapy-a%C3%A2-qualitative%C3%A2-study
#9
Inbar Levkovich, Miri Cohen, Khaled Karkabi
The study explored the experience of fatigue, its effects and ways of coping with fatigue and the role of family and social support among breast cancer patients. In-depth, semi-structured interviews were conducted with 13 breast cancer patients stages I-III, aged 34-67, who were up to one year after the termination of chemotherapy. Two main themes emerged: "Being imprisoned in the body of an 80-year-old", focuses the fatigue experienced by younger and older women, during and post treatment, including the different patterns of fatigue and the various means of coping with fatigue; The "Family's bear-hug" exemplifies the role of the environment in coping with the experience of fatigue and the complexities entailed in receiving support from family and friends...
November 2, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/29091007/harms-of-restrictive-risk-based-mammographic-breast-cancer-screening
#10
Colleen H Neal, W Tania Rahman, Annette I Joe, Mitra Noroozian, Renee W Pinsky, Mark A Helvie
OBJECTIVE: The objective of this study was to determine if restrictive risk-based mammographic screening could miss breast cancers that population-based screening could detect. MATERIALS AND METHODS: Through a retrospective search of records at a single institution, we identified 552 screen-detected breast cancers in 533 patients. All in situ and invasive breast cancers detected at screening between January 1, 2011, and December 31, 2014, were included. Medical records were reviewed for history, pathology, cancer size, nodal status, breast density, and mammographic findings...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29090030/cancer-related-fatigue-in-breast-cancer-survivors-in-correlation-to-demographic-factors
#11
Fatemeh Moghaddam Tabrizi, Saeedeh Alizadeh
BACKGROUND: Fatigue is one of the most frequent symptoms in cancer patients. However, its exact causes are still unknown, and this circumstance makes it complicated to encounter the problem. OBJECTIVE: The current research was carried out to investigate factors associated with fatigue in cancer patients without other diseases. MATERIALS AND METHODS: The research was conducted in 2013. A group of 150 randomly selected breast cancer patients who had successful surgical treatment and attending in oncology ward to receive chemotherapy and radiotherapy...
June 2017: Mædica
https://www.readbyqxmd.com/read/29076352/ethnic-disparities-in-cancer-incidence-and-survival-among-the-oldest-old-in-the-united-states
#12
Jessica L Krok-Schoen, Ingrid K Adams, Ryan D Baltic, James L Fisher
OBJECTIVE: To examine potential ethnic disparities in cancer incidence and survival rates among the oldest old using data from the SEER Program. DESIGN: Cases diagnosed with one of the leading four cancer sites (lung and bronchus, colon and rectum, female breast, prostate) and four cancer sites (stomach, liver and intrahepatic bile duct, gallbladder, and cervical) that disproportionally affect Hispanics were reported to one of 18 SEER registries. Differences in cancer incidence were examined for cases aged ≥85 years diagnosed during the most recent 5-year time period (2009-2013) and, to examine changes over time, from 1992 to 2013...
October 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29072403/inconsistencies-of-breast-cancer-risk-factors-between-the-northern-and-southern-regions-of-vietnam
#13
Phuong Dung (Yun) Trieu, Claudia Mello-Thoms, Jennifer K Peat, Thuan Doan Do, Patrick C Brennan
Background: In recent decades the amount of new breast cancer cases in the southern region has been reported to increase more rapidly than in the northernVietnam. The aim of this study is to compare breast cancer risk factors between the two regions and establish if westernized influences have an impact on any reported differences. Method: Data was collected from the two largest oncology hospitals in the north and the south of Vietnam in 2015. Breast density, demographic, reproductive and lifestyle data of 127 cases and 269 controls were collected in the north and 141 cases and 250 controls were gathered from the south...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29064760/screening-mammography-in-women-40-49-years-old-current-evidence
#14
Kimberly M Ray, Bonnie N Joe, Rita I Freimanis, Edward A Sickles, R Edward Hendrick
OBJECTIVE: Breast cancer is an important health problem for women 40-49 years old, yet screening mammography for this age group remains controversial. This article reviews recent guidelines and supporting evidence on screening mammography in women of this age group. CONCLUSION: Evidence supports the benefit of annual screening mammography in women 40-49 years old. Models of different breast cancer screening strategies consistently show the greatest breast cancer mortality reduction and life-years gained with annual screening starting when women reach 40 years old...
October 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29055624/geriatric-assessment-and-biomarkers-in-patients-with-metastatic-breast-cancer-receiving-first-line-mono-chemotherapy-results-from-the-randomized-phase-iii-pelican-trial
#15
Friedemann Honecker, Nadia Harbeck, Claudia Schnabel, Ulrich Wedding, Dirk Waldenmaier, Steffen Saupe, Elke Jäger, Marcus Schmidt, Rolf Kreienberg, Lothar Müller, Burkhard Otremba, Julia Dorn, Mathias Warm, Salah-Eddin Al-Batran, Maike de Wit
OBJECTIVES: To determine predictive/prognostic factors for patients with metastatic breast cancer (MBC) receiving first-line monochemotherapy using biomarker analysis and geriatric assessment (GA). MATERIALS AND METHODS: Karnofsky Performance Status (KPS) and GA as clinical parameters, and prognostic inflammatory and nutritional index (PINI), and Glasgow prognostic score (GPS) as biomarkers were analyzed for association with clinical outcome within the randomized phase III PEg-LIposomal Doxorubicin vs...
October 18, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29055048/adolescent-obesity-and-adult-male-breast-cancer-in-a-cohort-of-1-382-093-men
#16
Lital Keinan-Boker, Hagai Levine, Adi Leiba, Estela Derazne, Jeremy D Kark
Male breast cancer (MBC) accounts for 1% of all breast cancer. Adult obesity and tallness are risk factors for MBC, but the role of adolescent fatness is largely unknown. We aimed to assess the association between body mass index (BMI) in adolescence and the incidence of MBC in a large cohort of 16-19 year-old Israeli males. 1,382,093 Jewish Israeli males aged 16-19 who underwent anthropometric measurements, a General Intelligence Test (GIT) and other examinations during 1967-2011, were followed up to 31.12...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29053170/radiation-therapy-utilization-in-medicare-beneficiaries-with-early-stage-breast-cancer
#17
Audrey S Wallace, Kimberley S Keene, Courtney P Williams, Bradford E Jackson, Maria Pisu, Edward E Partridge, Gabrielle B Rocque
BACKGROUND: There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS: Medicare beneficiaries who were 65 years old or older and were diagnosed with breast cancer at 1 of 12 cancer centers affiliated with an academic center in the southeastern United States were analyzed...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29039119/clinical-implications-of-germline-mutations-in-breast-cancer-tp53
#18
REVIEW
Katherine Schon, Marc Tischkowitz
PURPOSE: This review describes the prevalence of germline TP53 mutations, the risk of breast cancer and other cancers in mutation carriers and management implications for women with breast cancer and unaffected women. METHODS: Literature review of English language papers available through PubMed. RESULTS: Women who carry germline mutations in the TP53 gene have a very high risk of breast cancer of up to 85% by age 60 years. Most of these breast cancers are early onset with a median age at diagnosis of 34 years...
October 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29024822/pubertally-initiated-high-fat-diet-promotes-mammary-tumorigenesis-in-obesity-prone-fvb-mice-similarly-to-obesity-resistant-balb-c-mice
#19
Yirong Zhu, Mark D Aupperlee, Sandra Z Haslam, Richard C Schwartz
Premenopausal breast cancer is associated with increased animal fat consumption among normal-weight but not overweight women. Our previous findings in obesity-resistant BALB/c mice showed that a diet high in saturated animal fat (HFD) promotes mammary tumorigenesis in both DMBA carcinogenesis and Trp53-null transplant models. Having made these observations in BALB/c mice, which have very modest HFD weight gain, we determined the effects of HFD in FVB mice, which gain significant weight on HFD. Three-week-old FVB mice fed a low-fat diet or HFD were subjected to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis...
December 2017: Translational Oncology
https://www.readbyqxmd.com/read/28964577/identification-of-p4ha1-as-a-prognostic-biomarker-for-high-grade-gliomas
#20
Wan-Ming Hu, Ji Zhang, Shu-Xin Sun, Shao-Yan Xi, Zhi-Jie Chen, Xiao-Bing Jiang, Fu-Hua Lin, Zheng-He Chen, Yin-Sheng Chen, Jian Wang, Qun-Ying Yang, Cheng-Cheng Guo, Yong-Gao Mou, Zhong-Ping Chen, Jing Zeng, Ke Sai
BACKGROUND: Prolyl 4-Hydroxylase Subunit Alpha 1 (P4HA1) is the active catalytic component of prolyl 4-hydroxylase and plays a crucial role in modulating extracellular matrix hemostasis. P4HA1 has been reported to promote tumor progression by enhancing invasion and angiogenesis. Overexpression of P4HA1 is associated with decreased survival for patients with breast and prostate cancer. However, the prognostic significance of P4HA1 for glioma patients remains undefined. METHODS: The expression of P4HA1 in 290 gliomas (WHO grade II-IV) and 10 normal brain tissues was examined with TMA-based immunohistochemistry assay...
September 18, 2017: Pathology, Research and Practice
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