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https://www.readbyqxmd.com/read/28618843/risk-of-cardiac-death-among-cancer-survivors-in-the-united-states-a-seer-database-analysis
#1
Omar Abdel-Rahman
 Background: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28616237/higher-serum-concentrations-of-vimentin-and-dakp1-are-associated-with-aggressive-breast-tumour-phenotypes-in-ghanaian-women
#2
Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay, Joe-Nat Clegg-Lamptey
BACKGROUND: Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade tumours with low hormone receptor positivity. Aggressive breast cancers grow quickly, easily metastasize and recur and often have unfavourable outcomes. The current study investigated candidate genes that may regulate tumour aggression in Ghanaian women. We hypothesize that increased expression and function of certain genes other than the widely-held view attributing breast cancer aggression in African populations to their younger population age may be responsible for the aggressive nature of tumours...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28612598/relationship-between-breast-cancer-and-oral-contraceptive-use-among-thai-premenopausal-women-a-case-control-study
#3
Wisit Chaveepojnkamjorn, Natchaporn Pichainarong, Rungsinoppadol Thotong, Pratana Sativipawee, Supachai Pitikultang
Background: Breast cancer (BC) is an important issue both in medicine and public health as it is the leading malignancy with high incidence and mortality among women worldwide. The objective of this research was to determine the associations of BC with oral contraceptive (OC) use among Thai premenopausal women (TPW). Materials and Methods: A case-control study was conducted among TPW attending the National Cancer Institute, with 257 cases and 257 controls in 2013-2014. Cases and controls were matched by age (± 5 years), residential area and duration of attendance...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28612228/pleomorphic-lobular-carcinoma-in-situ-of-the-breast-a-single-institution-experience-with-clinical-follow-up-and-centralized-pathology-review
#4
Marina De Brot, Starr Koslow Mautner, Shirin Muhsen, Victor P Andrade, Anita Mamtani, Melissa Murray, Dilip Giri, Rita A Sakr, Edi Brogi, Tari A King
PURPOSE: The natural history of pleomorphic lobular carcinoma in situ (PLCIS) remains largely unknown. METHODS: A pathology database search (1995-2012) was performed to identify patients diagnosed with an LCIS variant. Patients with synchronous breast cancer and/or no evidence of pleomorphism were excluded. Original slides were re-evaluated by three pathologists to identify a consensus cohort of PLCIS. Borderline lesions with focal atypia were classified as LCIS with pleomorphic features (LCIS-PF)...
June 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28597470/breast-conservation-for-male-breast-cancer-case-report-of-intraoperative-radiation
#5
Ameer Gomberawalla, Peter Liou, Rebecca Martinez, Raj Rajpara, Eileen Connolly, David Horowitz, Sheldon Feldman
Male breast cancer (MBC) comprises <1% of all breast cancers in the United States. MBC is typically treated with total mastectomy while the majority of female breast cancer is treated with breast conservation therapy combined with various forms of radiation. One method that has developed over the last two decades is the use of intraoperative radiation therapy (IORT) as a type of accelerated partial breast irradiation to direct the treatment field to the tumor bed. Since overall prognosis and systemic therapy recommendations for MBC are similar to breast cancer in women, we describe the first case of MBC treated with BCS and IORT...
June 8, 2017: Breast Journal
https://www.readbyqxmd.com/read/28597110/acculturation-matters-in-the-relation-between-ambivalence-over-emotional-expressions-and-well-being-among-chinese-american-breast-cancer-survivors
#6
William Tsai, Qian Lu
PURPOSE: Ambivalence over emotional expression (AEE) is the inner conflict of desiring emotion expression and fearing consequence of emotion expression. Few studies to date have examined the effects of AEE within an ethnic group that prioritizes emotional self-control. The present study examined the associations between AEE and well-being (viz., quality of life and depressive symptoms) as a function of acculturation among a sample of Chinese American breast cancer survivors. METHODS: Ninety-six Chinese breast cancer survivors (M age = 54...
June 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28596921/practices-of-breast-self-examination-and-associated-factors-among-female-debre-berhan-university-students
#7
Kalayu Birhane, Miskir Alemayehu, Belayneh Anawte, Gebru Gebremariyam, Ruth Daniel, Semeneh Addis, Teshome Worke, Abdurrahman Mohammed, Wassie Negash
BACKGROUND: Breast cancer is the most prevalent form of cancer in Ethiopia of all female cancers. It is considered to be a progressive disease with a poor prognosis if detected late. Breast self-examination is an important prevention method of breast cancer. This study was aimed at assessing practice and associated factors of breast self-examination (BSE) among female Debre Berhan University students in Ethiopia. METHODS: A cross-sectional study was conducted in 2015 among 420 using self-administrated questionnaire...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28595442/quality-of-life-in-responders-after-palliative-radiation-therapy-for-painful-bone-metastases-using-eortc-qlq-c30-and-eortc-qlq-bm22-results-of-a-brazilian-cohort
#8
Lucas C Mendez, Srinivas Raman, Bo Angela Wan, José Luiz Padilha da Silva, Fábio Y Moraes, Kennya M L B Lima, Maurício F Silva, Maria Del Pilar Estevez Diz, Edward Chow, Gustavo Nader Marta
BACKGROUND: Bone metastases cause pain, suffering and impaired quality of life (QoL). Palliative radiotherapy (RT) and/or chemotherapy are effective methods in controlling pain, reducing analgesics use and improving QoL. This study goal was to investigate the changes in QoL scores among patients who responded to palliative treatment. METHODS: A prospective study evaluating the role of radiation therapy in a public academic hospital in São Paulo-Brazil recorded patients' opioid use, pain score, Portuguese version of QLQ-BM22 and QLQ-C30 before and 2 months after radiotherapy...
May 17, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28594380/effects-of-obesity-on-pro-oxidative-conditions-and-dna-damage-in-liver-of-dmba-induced-mammary-carcinogenesis-models
#9
Stepan Melnyk, Soheila Korourian, Joseph W Levy, Oleksandra Pavliv, Teresa Evans, Reza Hakkak
The prevalence of the overweight and obesity is on the rise worldwide. Obesity can increase the risk of certain cancers and liver steatosis development. Previously, we reported that obesity increased liver steatosis in a mammary tumor model, but little is known about the effects of obesity in the liver in regard to global DNA methylation, DNA damage, and oxidative/nitrosative stress. Using a mammary tumor model, we investigated the effects of obesity on oxidative stress and DNA reaction. Five-week-old lean and obese female rats were used...
June 8, 2017: Metabolites
https://www.readbyqxmd.com/read/28592099/-study-of-the-association-between-polymorphism-of-persistent-obesity-human-leptin-gene-leptin-receptor-gene-and-molecular-subtypes-of-breast-cancer
#10
X L Yuan, Z P Xu, C R Liu, L P Yan, P Tao, P Xiong, Q Li, M Zhou, H Li, M Zhao, J Y Li
Objectives: To explore the association between the polymorphism of persistent obesity and genetic variations in the LEP (human leptin gene, LEP) and LEPR (leptin receptor gene, LEPR) genes and different molecular subtypes of breast cancer. Methods: All 703 female patients of breast cancer diagnosed by histopathology in the Sichuan Cancer Hospital or the West China Hospital, excluding patients with metastatic breast cancer or mental disease, were selected as cases from April 2014 to May 2015. At the same time, 805 healthy women received physical examination in medical examination center of Sichuan People Hospital or Shuangliu maternal and child health care hospital, excluding those with therioma, breast disease, and mental disease, were enrolled in control group...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28592065/-impact-of-adjuvant-chemotherapy-on-the-prognosis-of-hormone-receptor-negative-breast-cancer-with-residual-lymph-node-disease-after-neoadjuvant-chemotherapy
#11
X Wang, Y J He, J F Li, Y T Xie, T F Wang, Z Q Fan, T Ouyang
Objective: To explore the influence of adjuvant chemotherapy on the prognosis of hormone receptor negative breast cancer with residual lymph node disease(RLND)after neoadjuvant chemotherapy. Methods: A total of 110 hormone receptor negative breast cancer patients treated with 4-8 cycles of neoadjuvant chemotherapy were respectively analysed between 2002 and 2012. Residual lymph node disease was comfirmed by subsequent radical mastectomy. Then all these patients were classified into two groups: patients treated with adjuvant chemotherapy(group A) and patients untreated with adjuvant chemotherapy(group B)...
May 30, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28590426/down-s-syndrome-and-triple-negative-breast-cancer-a-rare-occurrence-of-distinctive-clinical-relationship
#12
Nandini Dey, Amy Krie, Jessica Klein, Kirstin Williams, Amanda McMillan, Rachel Elsey, Yuliang Sun, Casey Williams, Pradip De, Brian Leyland-Jones
Down's syndrome (DS), the most common genetic cause of significant intellectual disability in children and adults is caused by the trisomy of either all or a part of human chromosome 21 (HSA21). Patients with DS mostly suffer from characteristic tumor types. Although individual patients of DS are at a higher risk for acute leukemia and testicular cancers, other types of solid tumors including breast cancers are mostly uncommon and have significantly lower-than-expected age-adjusted incidence rates. Except for an increased risk of retinoblastomas, and lymphomas, the risk of developing solid tumors has been found to be lower in both children and adults, and breast cancer was found to be almost absent (Hasle H...
June 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28589368/reassessing-risk-models-for-atypical-hyperplasia-age-may-not-matter
#13
REVIEW
Emanuele Mazzola, Suzanne B Coopey, Molly Griffin, Fernanda Polubriaginof, Julliette M Buckley, Giovanni Parmigiani, Judy E Garber, Barbara L Smith, Michele A Gadd, Michelle C Specht, Anthony Guidi, Kevin S Hughes
PURPOSE: The aim of this study was to investigate the influence of age at diagnosis of atypical hyperplasia ("atypia", ductal [ADH], lobular [ALH], or severe ADH) on the risk of developing subsequent invasive breast cancer or ductal carcinoma in situ (DCIS). METHODS: Using standard survival analysis methods, we retrospectively analyzed 1353 women not treated with chemoprevention among a cohort of 2370 women diagnosed with atypical hyperplasia to determine the risk relationship between age at diagnosis and subsequent breast cancer...
June 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28566973/perspective-of-saudi-women-in-the-makkah-region-on-breast-cancer-awareness
#14
Tahani H Nageeti, Arwa A N Abdelhameed, Raid A Jastania, Rania M Felemban
OBJECTIVE: To assess the perspective of Saudi women in the Makkah region on breast cancer awareness and early detection. MATERIALS AND METHODS: A mixed method study was conducted among 25-65 years old healthy Saudi females from Makkah region during the awareness campaign in October 2014. The participants were recruited by personal invitations at the women's places of work and social gatherings. The initial invitations were issued by either the research coordinator or the investigator...
May 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28550173/experimental-cardiac-radiation-exposure-induces-ventricular-diastolic-dysfunction-with-preserved-ejection-fraction
#15
Hirofumi Saiki, Gilles Moulay, Adam J Guenzel, Weibin Liu, Teresa Decklever, Kelly Classic, Linh Pham, Horng H Chen, John C Burnett, Stephen J Russell, Margaret M Redfield
BACKGROUND: Breast cancer radiotherapy increases the risk of heart failure (HF) with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radio-resistant but radiation specifically affects coronary microvascular endothelial cells with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28547655/sexual-health-needs-and-educational-intervention-preferences-for-women-with-cancer
#16
Cara Stabile, Shari Goldfarb, Raymond E Baser, Deborah J Goldfrank, Nadeem R Abu-Rustum, Richard R Barakat, Maura N Dickler, Jeanne Carter
PURPOSE: To assess sexual/vaginal health issues and educational intervention preferences in women with a history of breast or gynecologic cancer. METHODS: Patients/survivors completed a cross-sectional survey at their outpatient visits. Main outcome measures were sexual dysfunction prevalence, type of sexual/vaginal issues, awareness of treatments, and preferred intervention modalities. Descriptive frequencies were performed, and results were dichotomized by age, treatment status, and disease site...
May 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28541571/childhood-adolescent-and-young-adult-cancer-incidence-in-japan-in-2009-2011
#17
Kota Katanoda, Akiko Shibata, Tomohiro Matsuda, Megumi Hori, Kayo Nakata, Yoshitaka Narita, Chitose Ogawa, Wataru Munakata, Akira Kawai, Hiroshi Nishimoto
Little is known about cancer incidence among children and youths in Japan. We aimed to describe cancer incidence in Japan focusing on childhood, adolescence and young adulthood (AYA). Cancer incidence data were obtained from the Monitoring of Cancer Incidence in Japan project. For the 2009-2011 incidence, the data were collected from 40 prefectures, of which data from 27 prefectures meeting quality standards were analyzed (population coverage: 38.6%). Cancers diagnosed in 0-39 years of age were classified according to the International Classification of Childhood Cancer (version 3)...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28540271/cyp17-mspa1-gene-polymorphism-and-breast-cancer-patients-according-to-age-of-onset-in-cancer-institute-of-iran
#18
Elmira Ebrahimi, Tayebeh Sabokbar, Sharareh Eskandarieh, Vahideh Peyghambari, Reza Shirkoohi
BACKGROUND: Exposure to endogenous hormones such as estrogen is known as a lifetime Breast Cancer (BC) risk factor. Polymorphisms in genes that are involved in the steroidogenic process, such as Cytochrome P450c17alpha (CYP17), affect individuals' susceptibility to BC. In Iran, the highest incident of BC is among young women. This study aimed to find prevalence of Single Nucleotide Polymorphisms (SNPs) in genes such as CYP17 and significant correlation with age-oriented group of breast cancer...
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28536342/-a-case-of-late-recurrence-of-breast-cancer-causing-multiple-organ-metastases-27-years-postoperatively
#19
Kimiyasu Yoneyama, Hiroshi Nakamura, Naotaka Tobe
The patient was a 77-year-old female with a history of treatment for cancer of the right breast 27 years earlier, who presented with a chief complaint of a subcutaneous mass in the left lower quadrant of her abdomen. A thorough examination revealed high breast cancer-related tumor marker values, and based on a computed tomography(CT)examination, a tentative diagnosis of multiple lung, liver, retroperitoneal, and abdominal wall metastases was made. Although there were multiple organ metastases, in view of the long interval before the recurrence, absence of any symptoms, and the patient's age, we initiated treatment by weekly administration of an aromatase inhibitor and trastuzumab...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28535760/disparities-of-time-trends-and-birth-cohort-effects-on-invasive-breast-cancer-incidence-in-shanghai-and-hong-kong-pre-and-post-menopausal-women
#20
Feng Wang, Lap Ah Tse, Wing-Cheong Chan, Carol Chi-Hei Kwok, Siu-Lan Leung, Cherry Wu, Oscar Wai-Kong Mang, Roger Kai-Cheong Ngan, Mengjie Li, Wai-Cho Yu, Koon-Ho Tsang, Sze-Hong Law, Xiaoping Miao, Chunxiao Wu, Ying Zheng, Fan Wu, Xiaohong R Yang, Ignatius Tak-Sun Yu
BACKGROUND: Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20-25% of new female cancer incidents. This study aimed to describe the temporal trend of breast cancer and interpret the potential effects on the observed secular trends. METHODS: Cancer incident data were obtained from the cancer registries. Age-standardized incidence rate was computed by the direct method using the World population of 2000...
May 23, 2017: BMC Cancer
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