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Breast Sentinel node

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https://www.readbyqxmd.com/read/28718896/nomograms-for-preoperative-prediction-of-axillary-nodal-status-in-breast-cancer
#1
L Dihge, P-O Bendahl, L Rydén
BACKGROUND: Axillary staging in patients with breast cancer and clinically node-negative disease is performed by sentinel node biopsy (SLNB). The aim of this study was to integrate feasible preoperative variables into nomograms to guide clinicians in stratifying treatment options into no axillary staging for patients with non-metastatic disease (N0), SLNB for those with one or two metastases, and axillary lymph node dissection (ALND) for patients with three or more metastases. METHODS: Patients presenting to Skåne University Hospital, Lund, with breast cancer were included in a prospectively maintained registry between January 2009 and December 2012...
July 18, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28707391/role-of-sentinel-lymph-node-biopsy-as-a-staging-procedure-in-patients-with-melanoma-a-critical-appraisal
#2
REVIEW
Omgo E Nieweg, Alan Cooper, John F Thompson
Worldwide, sentinel node (SN) biopsy for accurate staging is now part of the standard work-up of patients with melanomas ≥1.0 mm Breslow thickness, as it is for staging patients with breast cancer. Nuclear medicine imaging and surgical techniques have evolved to such a degree that a SN can be identified and removed in virtually every patient. Nevertheless, some opposition to a routine SN biopsy remains, perhaps due to a failure to appreciate the serious implications of incomplete or inaccurate staging. Guided by a critical appraisal of the available evidence, this review elucidates the definition of an SN, discusses the sensitivity and specificity of the information it provides, emphasises that it is a minor staging procedure that can lead to improved survival when followed by appropriate therapy, and explains the necessarily unconventional and complex design of the only randomised trial that addresses this subject...
July 14, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28705929/use-of-tc-99m-tilmanocept-as-a-single-agent-for-sentinel-lymph-node-identification-in-breast-cancer-a-retrospective-pilot-study
#3
Jonathan Takei Unkart, Anne Marie Wallace
Introduction: Tc-99m tilmanocept (TcTM) received recent FDA-approval for lymphatic mapping. However, no prior studies have evaluated the use of TcTM as a single agent in sentinel lymph node (SLN) biopsy in breast cancer. Methods: We executed this retrospective, pilot study to assess the ability of TcTM to identify sentinel nodes as a single agent in clinically node-negative breast cancer patients. Patients received a single, intradermal injection overlying the tumor of either 0.5 mCi TcTM the day-of surgery or 2...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28700325/precise-intraoperative-sentinel-lymph-node-biopsies-guided-by-lymphatic-drainage-in-breast-cancer
#4
Xiaoyan Li, Sisi Chen, Liyu Jiang, Xiaoli Kong, Tingting Ma, Hong Xu, Qifeng Yang
The purpose of this study was to present a novel surgical method for intraoperative precise sentinel lymph node biopsy (SLNB) and to determine its clinical efficacy and sensitivity in breast cancer patients. The sentinel lymph nodes (SLNs) were preoperatively evaluated by axillary ultrasound. The intraoperative detection of SLNs was guided by lymphatic drainage pathway. The lymphatic vessels and SLNs were visualized. During operation, we searched for all the true SLNs (trSLNs), para-SLNs (paSLNs) and post-SLNs (poSLNs) followed lymphatic drainage ducts...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699134/intraoperative-tumor-detection-using-a-ratiometric-activatable-fluorescent-peptide-a-first-in-human-phase-1-study
#5
Jonathan T Unkart, Steven L Chen, Irene L Wapnir, Jesús E González, Alec Harootunian, Anne M Wallace
BACKGROUND: Positive surgical margins remain a significant challenge in breast cancer surgery. This report describes the use of a novel, first-in-human ratiometric activatable cell-penetrating peptide in breast cancer surgery. METHODS: A two-part, multi-institutional phase 1 trial of AVB-620 with a 3+3 dose escalation and dose-expansion cohorts was conducted. The patients received an infusion of AVB-620 2-20 h before planned lumpectomy/mastectomy and sentinel node biopsy/axillary dissection...
July 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28697552/the-importance-of-tattoo-pigment-in-sentinel-lymph-nodes
#6
Atilla Soran, Ebru Menekse, Amal Kanbour-Shakir, Kaori Tane, Emilia Diego, Marguerite Bonaventura, Ronald Johnson
BACKGROUND: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed. OBJECTIVE: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy. METHODS: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected...
July 6, 2017: Breast Disease
https://www.readbyqxmd.com/read/28695567/tc-99m-tilmanocept-versus-tc-99m-sulfur-colloid-in-breast-cancer-sentinel-lymph-node-identification-results-from-a-randomized-blinded-clinical-trial
#7
Jonathan T Unkart, Ava Hosseini, Anne M Wallace
INTRODUCTION: No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc-99m tilmanocept (TcTM) and Tc-99m sulfur colloid (TcSC) in breast cancer (BC). METHODS: We report on the secondary outcomes from a randomized, double-blinded, single surgeon clinical trial comparing post-injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, "hot", and blue nodes detected and removed were compared between groups...
July 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28693494/variation-of-sentinel-lymphatic-channels-slcs-and-sentinel-lymph-nodes-slns-assessed-by-contrast-enhanced-ultrasound-ceus-in-breast-cancer-patients
#8
Ying Wang, Wenbin Zhou, Cuiying Li, Haiyan Gong, Chunlian Li, Nianzhao Yang, Xiaoming Zha, Lin Chen, Tiansong Xia, Xiaoan Liu, Minghai Wang, Qiang Ding
BACKGROUND: The objective of this study was to assess the feasibility of detecting the variation of sentinel lymphatic channels (SLCs) and sentinel lymph nodes (SLNs) in breast cancer patients using contrast-enhanced ultrasound (CEUS). METHODS: A total of 46 breast cancer patients were prospectively recruited in the study. All the participants received intradermal and peritumoral injection of microbubbles as contrast agent, and SLCs and SLNs were assessed preoperatively...
July 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28690675/development-of-sentinel-node-biopsy-roll-and-iart-in-early-breast-cancer-at-the-european-institute-of-oncology-milan-ieo
#9
REVIEW
Giovanni Paganelli
The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28690104/a-clinical-perspective-on-regional-nodal-irradiation-for-breast-cancer
#10
Amy C Moreno, Simona F Shaitelman, Thomas A Buchholz
The goal of regional treatments in breast cancer should be to eradicate any disease within lymph nodes, avoid regional recurrences, minimize the risk of distant metastases, and improve survival. In addition, regional treatments should focus on reducing potential morbidities and optimizing the long-term quality of life of breast cancer survivors. While data from recent surgical and radiation trials have helped clarify many issues regarding regional treatment, there still remains controversy as to the optimal approach for patients with "intermediate risk" disease...
July 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28688667/clinical-utility-of-the-additional-use-of-blue-dye-for-indocyanine-green-for-sentinel-node-biopsy-in-breast-cancer
#11
Yinan Ji, Ningbin Luo, Yi Jiang, Qiuyun Li, Wei Wei, Huawei Yang, Jianlun Liu
BACKGROUND: Indocyanine green (ICG) is widely used as a tracer in sentinel lymph node biopsy (SLNB) of patients with breast cancer. Whether SLNB performance can be improved by supplementing ICG with methylene blue dye remains controversial. This study compared the performance of SLNB when ICG was used alone or with blue dye. MATERIALS AND METHODS: Consecutive patients with T1-3 primary breast cancer at our hospital were recruited into our study and randomized to undergo SLNB with ICG alone (n = 62) or with the combination of ICG and blue dye (n = 65)...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688661/use-of-axillary-lymph-node-dissection-alnd-in-patients-with-micrometastatic-breast-cancer
#12
Madison Collins, Cristina O'Donoghue, Weihong Sun, Jun-Min Zhou, Zhenjun Ma, Christine Laronga, Marie Catherine Lee
BACKGROUND: Sentinel lymph node (SLN) biopsy is the current prognostic tool for clinically node-negative breast cancer patients. If the SLN reveals macrometastasis, axillary lymph node dissection (ALND) is recommended. However, the use of ALND in patients with micrometastasis is debated. The objective of this study was to assess the utilization of ALND in the treatment of micrometastatic breast cancer. METHODS: An IRB approved, retrospective study of a pooled dataset of breast cancer patients with micrometastatic disease on SLN biopsy was performed...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28684896/a-technique-of-endoscopic-nipple-sparing-mastectomy-for-breast-cancer
#13
Yu Wang, Ji-Xiang Wu, Shan Guan
BACKGROUND AND OBJECTIVES: Nipple-sparing mastectomy (NSM) is a widely accepted surgical technique for patients with early breast cancer. The technique improves cosmetic outcomes, but a decrease in nipple sensitivity has been observed with NSM because of the incision into the nipple-areola complex (NAC). Endoscopic nipple-sparing mastectomy with skin lifting system (ENSMSLS) removes all breast tissue through the axillary incision used for the sentinel lymph node biopsy, to avoid incision around the NAC area...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28677240/application-of-automated-image-analysis-reduces-the-workload-of-manual-screening-of-sentinel-lymph-node-biopsies-in-breast-cancer
#14
Henrik Holten-Rossing, Maj-Lis Møller Talman, Anne Marie Bak Jylling, Anne-Vibeke Laenkholm, Martin Kristensson, Ben Vainer
INTRODUCTION: Breast cancer is one of the most common cancer diseases in women with more than 1.67 million cases diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumor spreads and it is usually located in the ipsilateral axilla. In patients with no clinical signs of metastatic disease in the axilla, a SLN biopsy (SLNB) is performed. Assessment of metastases in the SLNB is done in a conventional microscope by manually observing a metastasis and measuring its size and/or counting the number of tumor cells...
July 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28673537/de-escalating-and-escalating-surgery-in-the-management-of-early-breast-cancer
#15
Monica Morrow
In the setting of increased awareness regarding the need to address potential overtreatment in the management of breast cancer patients with favorable-prognosis disease, this article reviews three relevant instances in which the extent of surgery has been safely decreased: margin width in patients with ductal carcinoma in situ; axillary management in clinically node-negative women undergoing primary breast-conserving surgery; and the use of neoadjuvant chemotherapy followed by sentinel node biopsy for patients presenting with node-positive breast cancer...
June 30, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28673534/the-intraoperative-assessment-of-sentinel-nodes-standards-and-controversies
#16
M E M van der Noordaa, M T F D Vrancken Peeters, E J T Rutgers
Intraoperative assessment of sentinel lymph nodes (SLNs) has the advantage of allowing breast cancer patients with tumor-positive SLNs to avoid a second surgery by immediately proceeding to axillary lymph node dissection (ALND). However, there are several reasons why the use of intraoperative assessment should be questioned. Whereas ALND was traditionally advised for all breast cancer patients with tumor-positive lymph nodes for axillary staging and locoregional control, more recent studies have demonstrated safety of omitting ALND in a substantial number of patients...
June 30, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28668871/the-sentinel-node-with-isolated-breast-tumor-cells-or-micrometastases-benefits-and-risks-of-axillary-dissection
#17
Vilma Madekivi, Pia Boström, Ritta Aaltonen, Tero Vahlberg, Eeva Salminen
BACKGROUND/AIM: Sentinel lymph node (SLN) biopsy has become the standard procedure to identify metastases in axillary nodes in breast cancer. Even after careful SLN examination additional micrometastases and isolated tumor cells (ITCs) are sometimes found, resulting in a need for delayed axillary lymph node dissection (ALND). This study was undertaken to assess prognostic factors identifying additional axillary lymph node (ALN) metastases at delayed ALND. PATIENTS AND METHODS: To define the impact of late ALND regarding their outcome, 162 breast cancer patients with 169 operated breasts treated between 2010 and 2012 were evaluated, with follow-up through 2016...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28668073/clinically-node-negative-breast-cancer-patients-undergoing-breast-conserving-therapy-sentinel-lymph-node-procedure-versus-follow-up-a-dutch-randomized-controlled-multicentre-trial-boog-2013-08
#18
L M van Roozendaal, M L G Vane, T van Dalen, J A van der Hage, L J A Strobbe, L J Boersma, S C Linn, M B I Lobbes, P M P Poortmans, V C G Tjan-Heijnen, K K B T Van de Vijver, J de Vries, A H Westenberg, A G H Kessels, J H W de Wilt, M L Smidt
BACKGROUND: Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of the sentinel lymph node biopsy has no clinical consequence, the value of the procedure itself is being questioned. The aim of the BOOG 2013-08 trial is to investigate whether the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients treated with breast conserving therapy...
July 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28667103/expression-and-prognostic-value-of-her-2-neu-in-primary-breast-cancer-with-sentinel-lymph-node-metastasis
#19
Zhen-Jun Tong, Ning-Yao Shi, Zhi-Ji Zhang, Xiao-Dong Yuan, Xiao-Ming Hong
This study explores the correlation of human epidermal growth factor receptor-2 (HER-2) protein expression with sentinel lymph node (SLN) metastasis and prognosis of breast cancer. The breast cancer tissues and adjacent tissues were obtained from patients with primary breast cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the mRNA level of HER-2. Spearman correlation analysis was used to analyze the correlation of HER-2 expression with SLN metastasis. The disease-free survival (DFS) and overall survival (OS) of breast cancer patients were investigated...
June 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28661760/maximizing-the-clinical-benefit-of-anthracyclines-in-addition-to-taxanes-in-the-adjuvant-treatment-of-early-breast-cancer
#20
Giuseppe Curigliano, Carmen Criscitiello
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
June 29, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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