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https://www.readbyqxmd.com/read/28822666/reliability-of-left-ventricular-ejection-fraction-from-three-dimensional-echocardiography-for-cardiotoxicity-onset-detection-in-patients-with-breast-cancer
#1
Cinzia Lorenzini, Claudio Lamberti, Michele Aquilina, Andrea Rocca, Pietro Cortesi, Cristiana Corsi
BACKGROUND: Cardiotoxicity is a well-known adverse effect of various chemotherapeutic agents that can be monitored by echocardiography. A decrease in left ventricular ejection fraction (LVEF) triggers consideration for therapy modification or interruption. The aim of this study was to evaluate how variability in LVEF estimates computed using three-dimensional echocardiography could influence cardiotoxicity onset detection. METHODS: One hundred eighty one patients with breast cancer treated with anthracycline and trastuzumab were analyzed...
August 16, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28822394/the-clinical-utility-and-cost-of-postoperative-mammography-completed-within-one-year-of-breast-conserving-therapy-is-it-worth-it
#2
Ahkeel Allen, Allison Cauthen, Justin Vaughan, Paul Dale
Breast conserving therapy (BCT), lumpectomy followed by radiotherapy, is an effective treatment for a majority of breast cancers. According to the National Comprehensive Cancer Network, mammographic imaging should be completed at least six months after completion of radiation. This study evaluates the clinical significance and financial cost of postoperative breast imaging within one year of BCT. Patients treated with BCT between 2014 and 2016 at an academic center were identified retrospectively. The medical records were reviewed to identify the timing and type of the first imaging study after BCT...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821993/segmentation-of-breast-ultrasound-images-based-on-active-contours-using-neutrosophic-theory
#3
Mahsa Lotfollahi, Masoumeh Gity, Jing Yong Ye, A Mahlooji Far
PURPOSE: Ultrasound imaging is an effective approach for diagnosing breast cancer, but it is highly operator-dependent. Recent advances in computer-aided diagnosis have suggested that it can assist physicians in diagnosis. Definition of the region of interest before computer analysis is still needed. Since manual outlining of the tumor contour is tedious and time-consuming for a physician, developing an automatic segmentation method is important for clinical application. METHODS: The present paper represents a novel method to segment breast ultrasound images...
August 18, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28821205/cerebrospinal-fluid-circulating-tumor-cells-a-novel-tool-to-diagnose-leptomeningeal-metastases-from-epithelial-tumors
#4
Xuling Lin, Martin Fleisher, Marc Rosenblum, Oscar Lin, Adrienne Boire, Samuel Briggs, Yevgeniya Bensman, Brenda Hurtado, Larisa Shagabayeva, Lisa M DeAngelis, Katherine S Panageas, Antonio Omuro, Elena I Pentsova
Background: Diagnosis of leptomeningeal metastasis (LM) remains challenging due to low sensitivity of CSF cytology and infrequent unequivocal MRI findings. In a previous pilot study, we showed that rare cell capture technology (RCCT) could be used to detect circulating tumor cells (CTC) in the CSF of patients with LM from epithelial tumors. To establish the diagnostic accuracy of CSF-CTC in the diagnosis of LM, we applied this technique in a distinct, larger cohort of patients. Methods: In this institutional review board-approved prospective study, patients with epithelial tumors and clinical suspicion of LM underwent CSF-CTC evaluation and standard MRI and CSF cytology examination...
September 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28820837/non-contrast-mr-lymphography-for-evaluation-of-lymph-node-transfer-for-secondary-upper-limb-lymphedema
#5
Lionel Arrivé, Sarah Derhy, Chrif Dlimi, Sanaa El Mouhadi, Laurence Monnier-Cholley, Corinne Becker
BACKGROUND: Our purpose was to evaluate the results of axillary lymph node transplantation (LNT) with non-contrast magnetic resonance (MR) lymphography in 15 patients with secondary upper limb lymphedema. METHODS: Fifteen female patients with lymphedema following breast cancer treatment underwent LNT. Non-contrast MR lymphography was obtained with a free-breathing 3D fast spin-echo sequence. Images analysis criteria included: (A) before surgery: a) severity of lymphedema graded as absent, mild, moderate, and severe; b) involvement of the muscular compartment; c) distal dilated lymphatic vessels; (B) after surgery: a) visualization of site of transplantation; b) visualization of transplanted lymph nodes; c) severity of lymphedema with regard to pretransplantation severity (i...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28819962/monte-carlo-simulations-support-non-cerenkov-radioluminescence-production-in-tissue
#6
Nicole L Ackerman, Federico Boschi, Antonello E Spinelli
There is experimental evidence for the production of non-Cerenkov radioluminescence in a variety of materials, including tissue. We constructed a Geant4 Monte Carlo simulation of the radiation from P32 and Tc99m interacting in chicken breast and used experimental imaging data to model a scintillation-like emission. The same radioluminescence spectrum is visible from both isotopes and cannot otherwise be explained through fluorescence or filter miscalibration. We conclude that chicken breast has a near-infrared scintillation-like response with a light yield three orders of magnitude smaller than BGO...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28819909/adjunctive-breast-specific-gamma-imaging-for-detecting-cancer-in-women-with-calcifications-at-mammography
#7
Hyun Woo Chung, Young So, Jung-Hyun Yang, Kyoung Sik Park, Young Bum Yoo, Nami Choi, Mi Young Kim, Jayoun Kim, Eun Jeong Lee
BACKGROUND: Mammography detects calcium deposits sensitively, but the specificity for differentiating malignancy from benign calcifications is low. Thus, we investigated whether adjunctive breast-specific gamma imaging (BSGI) has incremental value for detecting cancer in women with suspicious calcifications detected by mammography, and compared BSGI with adjunctive ultrasonography (US). METHODS: The medical records of women without a personal history of breast cancer who underwent mammography for breast evaluation from 2009 to 2014 were reviewed retrospectively...
August 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28819862/radiation-dose-with-digital-breast-tomosynthesis-compared-to-digital-mammography-per-view-analysis
#8
Gisella Gennaro, D Bernardi, N Houssami
OBJECTIVES: To compare radiation dose delivered by digital mammography (FFDM) and breast tomosynthesis (DBT) for a single view. METHODS: 4,780 FFDM and 4,798 DBT images from 1,208 women enrolled in a screening trial were used to ground dose comparison. Raw images were processed by an automatic software to determine volumetric breast density (VBD) and were used together with exposure data to compute the mean glandular dose (MGD) according to Dance's model. DBT and FFDM were compared in terms of operation of the automatic exposure control (AEC) and MGD level...
August 17, 2017: European Radiology
https://www.readbyqxmd.com/read/28819781/comparison-of-synthetic-mammography-reconstructed-from-digital-breast-tomosynthesis-and-digital-mammography-evaluation-of-lesion-conspicuity-and-bi-rads-assessment-categories
#9
Giovanna Mariscotti, Manuela Durando, Nehmat Houssami, Mirella Fasciano, Alberto Tagliafico, Davide Bosco, Cristina Casella, Camilla Bogetti, Laura Bergamasco, Paolo Fonio, Giovanni Gandini
PURPOSE: To compare the interpretive performance of synthetic mammography (SM), reconstructed from digital breast tomosynthesis (DBT), and full-field digital mammography (FFDM) in a diagnostic setting, covering different conditions of breast density and mammographic signs. METHODS: A retrospective analysis was conducted on 231 patients, who underwent FFDM and DBT (from which SM images were reconstructed) between September 2014-September 2015. The study included 250 suspicious breast lesions, all biopsy proven: 148 (59...
August 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28819203/differential-diagnostic-performance-of-acoustic-radiation-force-impulse-imaging-in-small-%C3%A2-20%C3%A2-mm-breast-cancers-is-it-valuable
#10
Si-Da Wang, Lei Wang, Zhi-Xian Li, Kang-Lai Wei, Xin-Hong Liao, Yuan-Yuan Chen, Xue Huang
To evaluate acoustic radiation force impulse (ARFI) inthe differential diagnosis of small (≤20 mm) solid breast lesions and identify the most efficient ARFI parameters. Conventional ultrasonography and ARFIwere performed in 120 patients with 121 small solid breast lesions. The area ratios (ARs) of the lesion on virtual touch tissue compared to B-mode were calculated. The shear wave velocity of the inner (SWVi) and boundary (SWVb) of the lesions and surrounding fatty tissue (SWVf) was measured. The ratio of SWVi to SWVf (SWVrat) was calculated...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818992/long-half-life-89-zr-labeled-radiotracers-can-guide-in-suite-percutaneous-molecular-imaging-pet-ct-guided-biopsies-without-reinjection-of-radiotracer
#11
Francois H Cornelis, Jeremy Durack, Neeta Pandit-Taskar, Gary A Ulaner, Jason S Lewis, Michael J Morris, Stephen B Solomon
Rationale: To evaluate the feasibility of in suite Zr89 labeled radiotracer positron emission tomography-computed tomography (PET/CT)-guided biopsies performed without reinjection. Methods: From 2013-2016, 12 patients (7 males, 5 females; mean age 61 years, range 40-75) with suspected metastatic prostate or breast carcinoma on either imaging or biochemical progression underwent 14 percutaneous biopsies after diagnostic PET/CT using (89)Zr labeled radiotracers (mean dose: 180MBq; range: 126-189MBq) targeting prostate specific membrane antigen (PSMA) (n = 7) or human epidermal growth factor receptor 2 (HER2) (n = 5)...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28817195/vertical-off-centering-affects-organ-dose-in-chest-ct-evidence-from-monte-carlo-simulations-in-anthropomorphic-phantoms
#12
Natalia Saltybaeva, Hatem Alkadhi
PURPOSE: The objective of our study was to assess the effect of patient vertical off-centering on organ dose in chest CT with tube current modulation. METHODS: For this purpose, anthropomorphic phantoms representing adult male, female and overweight male were scanned on 192-slice CT scanner at eleven different vertical positions (maximal off-centering ± 5 cm). Monte Carlo simulations were performed for each of the investigated setup, using tube current values extracted from the raw data, in order to obtain 3D dose distributions...
August 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28817147/supramolecular-core-glycoshell-polythiophene-nanodots-for-targeted-imaging-and-photodynamic-therapy
#13
Hai-Hao Han, Chang-Zheng Wang, Yi Zang, Jia Li, Tony D James, Xiao-Peng He
Supramolecular self-assembly between poly(3-hexylthiophene-2,5-diyl) (P3HT), a polymeric material extensively used for optoelectronic devices, and fluorescent glycoprobes produces core-glycoshell theranostic nanodots (glyco-dots) capable of targeted imaging and photodynamic therapy of liver and triple-negative breast cancer cells.
August 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28816987/analysis-of-background-parenchymal-echogenicity-on-breast-ultrasound-correlation-with-mammographic-breast-density-and-background-parenchymal-enhancement-on-magnetic-resonance-imaging
#14
Kyung Hee Ko, Hae Kyoung Jung, Inwha Kim
The purpose of this study was to analyze the background parenchymal echotexture (BP echo) on breast ultrasound in detail and to evaluate the relation BP echo with menopausal status. In addition, we correlated BP echo with mammographic breast density (MGD) and background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI).The institutional review board of our hospital approved this retrospective study, and the requirement of informed consent was waived. We studied 138 women (mean age 51.6 years, range from 26 to 79 years) with newly diagnosed invasive breast cancer, who had performed preoperative mammography, ultrasound, and MR from June 2013 to June 2015...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816145/strain-imaging-detects-dose-dependent-segmental-cardiac-dysfunction-in-the-acute-phase-after-breast-irradiation
#15
Queenie Lo, Leia Hee, Vikneswary Batumalai, Christine Allman, Peter MacDonald, Denise Lonergan, Geoff P Delaney, Liza Thomas
PURPOSE: We examined the utility of echocardiographic 2-dimensional speckle tracking strain imaging (SI) for the evaluation of segmental myocardial dysfunction before and after radiation therapy (RT) and the relationship to dose exposure. METHODS AND MATERIALS: We prospectively recruited 40 women with left-sided breast cancer, undergoing only adjuvant RT to the left chest. Comparisons of traditional echocardiographic parameters and SI parameters at baseline and 6 weeks after RT were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28814795/direct-comparison-of-pet-ct-and-mri-to-predict-the-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-a-meta-analysis
#16
Lihua Chen, Qifang Yang, Jing Bao, Daihong Liu, Xuequan Huang, Jian Wang
Both PET/CT and breast MRI are used to assess pathological complete response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. The aim is to compare the utility of PET/CT and breast MRI by using head-to-head comparative studies. Literature databases were searched prior to July 2016. Eleven studies with a total of 527 patients were included. For PET/CT, the pooled SEN was 0.87 (95% confidence interval (CI): 0.71-0.95) and SPE was 0.85 (95% CI: 0.70-0.93). For MRI, the pooled SEN was 0.79 (95% CI: 0...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813198/radial-scars-of-the-breast-encountered-at-core-biopsy-review-of-histologic-imaging-and-management-considerations
#17
Michael A Cohen, Mary S Newell
OBJECTIVE: The purposes of this article are to place the controversy over the management of radial scars diagnosed at core biopsy in perspective and to define reasonable management options. CONCLUSION: The management of radial scars after image-guided core biopsy of the breast for diagnosis remains controversial. Although current literature suggests no premalignant potential of these lesions, it does not fully explain the small but real percentage of these lesions that are upgraded to malignancy after surgical excision...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#18
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812190/diagnostic-value-of-the-stand-alone-synthetic-image-in-digital-breast-tomosynthesis-examinations
#19
Julia Garayoa, Margarita Chevalier, Maria Castillo, Ignacio Mahillo-Fernández, Najim Amallal El Ouahabi, Carmen Estrada, Alejandro Tejerina, Olivia Benitez, Julio Valverde
OBJECTIVE: To demonstrate the non-inferiority of synthetic image (SI) mammography versus full-field digital mammography (FFDM) in breast tomosynthesis (DBT) examinations. METHODS: An observational, retrospective, single-centre, multireader blinded study was performed, using 2384 images to directly compare SI and FFDM based on Breast Imaging Reporting and Data System (BIRADS) categorisation and visibility of radiological findings. Readers had no access to digital breast tomosynthesis slices...
August 15, 2017: European Radiology
https://www.readbyqxmd.com/read/28811996/experimental-method-and-statistical-analysis-to-fit-tumor-growth-model-using-spect-ct-imaging-a-preclinical-study
#20
Ivan Hidrovo, Joyoni Dey, Megan E Chesal, Dmytro Shumilov, Narayan Bhusal, J Michael Mathis
BACKGROUND: Over the last decade, several theoretical tumor-models have been developed to describe tumor growth. Oncology imaging is performed using various modalities including computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and fluorodeoxyglucose-positron emission tomography (FDG-PET). Our goal is to extract useful, otherwise hidden, quantitative biophysical parameters (such as growth-rate, tumor-necrotic-factor, etc.) from these serial images of tumors by fitting mathematical models to images...
June 2017: Quantitative Imaging in Medicine and Surgery
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