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https://www.readbyqxmd.com/read/29917035/how-can-nanotechnology-help-the-fight-against-breast-cancer
#1
REVIEW
Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco, Lucia Gemma Delogu
In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis...
June 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29916773/grouped-amorphous-calcifications-at-mammography-frequently-atypical-but-rarely-associated-with-aggressive-malignancy
#2
Hayley C Oligane, Wendie A Berg, Andriy I Bandos, Sue S Chen, Sahand Sohrabi, Maria Anello, Margarita L Zuley
Purpose To determine rate of malignancy at stereotactic biopsy of amorphous calcifications with different distributions using current imaging, clinical, and histopathologic criteria. Materials and Methods From January 2009 to September 2013, this retrospective study reviewed a large set of stereotactic biopsies to identify amorphous calcifications and their clinical, imaging, and histopathologic characteristics. Calcification distribution was correlated with malignancy rate after adjusting for known risk factors using logistic regression...
June 19, 2018: Radiology
https://www.readbyqxmd.com/read/29916500/pa-us-dual-modality-imaging-to-guide-vegfr-2-targeted-photothermal-therapy-using-znpc-pfh-loaded-polymeric-nanoparticles
#3
Yu-Li Chen, Feng-Qiu Liu, Yuan Guo, Juan Cheng, Lu Yang, Min Lu, Pan Li, Jie Xu, Tao Yu, Zhi-Gang Wang, Yang Cao, Hai-Tao Ran
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently...
June 19, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29914908/prevalence-and-outcomes-of-incidental-imaging-findings-umbrella-review
#4
Jack W O'Sullivan, Tim Muntinga, Sam Grigg, John P A Ioannidis
OBJECTIVE: To provide an overview of the evidence on prevalence and outcomes of incidental imaging findings. DESIGN: Umbrella review of systematic reviews. DATA SOURCES: Searches of MEDLINE, EMBASE up to August 2017; screening of references in included papers. ELIGIBILITY CRITERIA: Criteria included systematic reviews and meta-analyses of observational studies that gave a prevalence of incidental abnormalities ("incidentalomas")...
June 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29914892/radiomics-signature-on-magnetic-resonance-imaging-association-with-disease-free-survival-in-patients-with-invasive-breast-cancer
#5
Hyunjin Park, Yaeji Lim, Eun Sook Ko, Hwan-Ho Cho, Jeong Eon Lee, Boo-Kyung Han, Eun Young Ko, Ji Soo Choi, Ko Woon Park
PURPOSE: To develop a radiomics signature based on preoperative magnetic resonance imaging (MRI) to estimate disease-free survival (DFS) in patients with invasive breast cancer and to establish a radiomics nomogram that incorporates the radiomics signature and MRI and clinicopathological findings. EXPERIMENTAL DESIGN: We identified 294 patients with invasive breast cancer who underwent preoperative MRI. Patients were randomly divided into training (n = 194) and validation (n = 100) sets...
June 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29913935/adult-limb-and-breast-amputees-experience-and-descriptions-of-phantom-phenomena-a-qualitative-study
#6
Berit Björkman, Staffan Arnér, Iréne Lund, Lars-Christer Hydén
Background Phantom phenomena - pain or other sensations appearing to come from amputated body parts - are frequent consequences of amputation and can cause considerable suffering. Also, stump pain, located in the residual limb, is in the literature often related to the phantom phenomena. The condition is not specific to amputated limbs and has, to a lesser extent, been reported to be present after radical surgery in other body parts such as breast, rectum and teeth. Multi-causal theories are used when trying to understand these phenomena, which are recognized as the result of complex interaction among various parts of the central nervous system confirmed in studies using functional brain imaging techniques...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913554/expression-and-function-of-hexose-transporters-glut1-glut2-and-glut5-in-breast-cancer-effects-of-hypoxia
#7
Ingrit Hamann, Daniel Krys, Darryl Glubrecht, Vincent Bouvet, Alison Marshall, Larissa Vos, John R Mackey, Melinda Wuest, Frank Wuest
Elevated growth in breast cancer (BC) activates hypoxia-inducible factor (HIF1α) and downstream, facilitative glucose transporter 1 (GLUT1), which can be visualized with 2-deoxy-2-[18 F]fluoro-d-glucose ([18 F]FDG). GLUT5 (fructose) and GLUT2 (glucose/fructose) might provide alternative targets for BC imaging as to why effects of hypoxia on GLUT1/2/5 levels and function were examined in human BC models. GLUT1/2/5 and HIF1α mRNA was analyzed in BC patient biopsies. In MCF10A, MCF7, and MDA-MB231 cells, [18 F]FDG, 6-deoxy-6-[18 F]fluoro-d-fructose (6-[18 F]FDF) and [18 F]-fluoroazomycin arabinoside were used in radiotracer experiments, whereas GLUT1/2/5 mRNA was analyzed with real-time PCR and protein levels determined via Western blot/immunohistochemistry...
April 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29913305/an-investigation-of-the-viscoelastic-properties-and-the-actin-cytoskeletal-structure-of-triple-negative-breast-cancer-cells
#8
Jingjie Hu, Yuxiao Zhou, John D Obayemi, Jing Du, Winston O Soboyejo
An improved understanding of the evolution of cell structure and viscoelasticity with cancer malignancy could enable the development of a new generation of biomarkers and methods for cancer diagnosis. Hence, in this study, we present the viscoelastic properties (moduli and viscosities) and the actin cytoskeletal structures of triple negative breast cancer (TNBC) cells with different metastatic potential. These include: MCF-10A normal breast cells (studied as a control); MDA-MB-468 cells (less metastatic TNBC cells), and MDA-MB-231 cells (highly metastatic TNBC cells)...
May 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29912618/caloric-restriction-counteracts-chemotherapy-induced-inflammation-and-increases-response-to-therapy-in-a-triple-negative-breast-cancer-model
#9
Brittany A Simone, Ajay Palagani, Kimberly Strickland, Kevin Ko, Lianjin Jin, Meng Kieng Lim, Tu D Dan, Mak Sarich, Daniel A Monti, Massimo Cristofanilli, Nicole L Simone
Triple negative breast cancer (TNBC) is a heterogeneous disease that has no available targeted therapies. Previously, we have shown that caloric restriction (CR) can augment the effects of radiation therapy in a TNBC mouse model. To build upon this, we now present data regarding the combination of chemotherapy and CR in the same 4T1 model. Chemotherapy can induce inflammation that breeds resistance to therapy. We propose CR as a mechanism to decrease chemotherapy-induced inflammation and increase efficacy of therapy...
June 18, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29912273/evaluation-of-retropectoral-fat-grafting-in-breast-reduction-by-magnetic-resonance-imaging-a-pilot-study
#10
Paulo Afonso Monteiro Pacheco Guimarães, Miguel Sabino Neto, Fabiana Claudino Lage, Fernanda Ferreira Guirado, Giselle Guedes Netto de Mello, Lydia Masako Ferreira
Background: One of the challenges in breast reduction is to maintain breast projection with 45% of its volume in the upper pole and 55% in the lower pole. Although widely used in breast surgeries, the behavior of fat grafts is still not completely understood. Objectives: To evaluate by magnetic resonance imaging (MRI) the survival of fat transferred to the retropectoral plane in patients undergoing breast reduction, in the search for an oncologically safe procedure with high predictability and reproducibility...
June 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29911967/from-principles-to-practice-real-world-patient-and-stakeholder-engagement-in-breast-cancer-research
#11
Sarah M Greene, Susan Brandzel, Karen J Wernli
The Patient-Centered Outcomes Research Institute (PCORI) in Washington, DC, has catalyzed a meaningful shift in the composition of research project teams since its initial research funding cycle in 2011. Despite the influx of funding in the research community for patient-centered research, research on how to effectively engage patients and stakeholders in the research process is still relatively nascent. Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle, WA, was an early recipient of PCORI research funding and, as of December 2017, has received 8 PCORI research awards totaling nearly $15 million...
June 6, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29911682/contact-guidance-is-cell-cycle-dependent
#12
Kamyar Esmaeili Pourfarhangi, Edgar Cardenas De La Hoz, Andrew R Cohen, Bojana Gligorijevic
Cancer cell migration is essential for metastasis, during which cancer cells move through the tumor and reach the blood vessels. In vivo , cancer cells are exposed to contact guidance and chemotactic cues. Depending on the strength of such cues, cells will migrate in a random or directed manner. While similar cues may also stimulate cell proliferation, it is not clear whether cell cycle progression affects migration of cancer cells and whether this effect is different in random versus directed migration. In this study, we tested the effect of cell cycle progression on contact guided migration in 2D and 3D environments, in the breast carcinoma cell line, FUCCI-MDA-MB-231...
September 2018: APL bioengineering
https://www.readbyqxmd.com/read/29910836/neoplasm-of-uncertain-behaviour-of-the-breast-a-retrospective-study-in-a-breast-unit
#13
Xavier de Sousa, Pedro Santos Ferreira, Luís Branco, Jorge Simões, Matilde Gonçalves, Manuel Vítor Rigueira, Luís Cortez
Introduction: Breast lesions include a heterogeneous group of entities with variable clinical behaviour and morphological presentation, mostly classified as benign or malignant, with predictable behaviour. However, there are lesions with clinical, breast imaging and/or biopsy characteristics that do not clarify their nature. These lesions have an uncertain behaviour regarding their malignant potential at diagnosis.We intend to relate the preoperative diagnosis of neoplasm of uncertain behaviour of the breast (NUnBB) regarding the core needle biopsy and the histological result after excisional biopsy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910831/postoperative-radiotherapy-after-nipple-or-skin-sparing-mastectomy-a-review-of-recent-institutional-and-pooled-data
#14
REVIEW
Jacques Bernier
The increasing use of nipple-sparing mastectomy (NSM) and skin-sparing mastectomy (SSM) in the treatment of nonmetastatic breast cancer is justified by considerations linked to their therapeutic index. In selected patients, efficacy results tend to be similar to those observed after radical modified mastectomy and at the same time, subcutaneous mastectomies preserve the patient's body image. Yet the oncologic safety of the two former surgical approaches is still a matter of debate, also in consideration of the almost complete absence of clinical studies directed to prospective, controlled comparisons between subcutaneous and radical modified mastectomies...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910654/screening-for-breast-cancer-in-2018-what-should-we-be-doing-today
#15
REVIEW
J M Seely, T Alhassan
Although screening mammography has delivered many benefits since its introduction in Canada in 1988, questions about perceived harms warrant an up-to-date review. To help oncologists and physicians provide optimal patient recommendations, the literature was reviewed to find the latest guidelines for screening mammography, including benefits and perceived harms of overdiagnosis, false positives, false negatives, and technologic advances. For women 40-74 years of age who actually participate in screening every 1-2 years, breast cancer mortality is reduced by 40%...
June 2018: Current Oncology
https://www.readbyqxmd.com/read/29910171/characterization-of-breast-lesion-using-t-1-perfusion-magnetic-resonance-imaging-qualitative-vs-quantitative-analysis
#16
S Thakran, P K Gupta, V Kabra, I Saha, P Jain, R K Gupta, A Singh
OBJECTIVES: The objective of this study was to quantify the hemodynamic parameters using first pass analysis of T1 -perfusion magnetic resonance imaging (MRI) data of human breast and to compare these parameters with the existing tracer kinetic parameters, semi-quantitative and qualitative T1 -perfusion analysis in terms of lesion characterization. MATERIALS AND METHODS: MRI of the breast was performed in 50 women (mean age, 44±11 [SD] years; range: 26-75) years with a total of 15 benign and 35 malignant breast lesions...
June 14, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29908002/shielding-a-high-sensitivity-digital-detector-from-electromagnetic-interference
#17
David E Hintenlang, Xia Jiang, Kevin J Little
PURPOSE: To document a study in shielding a high-sensitivity digital mammography system detector from AC magnetic fields of magnitudes great enough to induce imaging artifacts. METHODS/MATERIALS: Preliminary evaluation of AC magnetic fields at a site designated for a digital breast tomosynthesis (DBT) system raised concerns that the magnetic component of electromagnetic interference (EMI) may be great enough to induce imaging artifacts. Subsequent measurements using digital detector arrays from two separate manufacturers verified this concern, and AC magnetic fields were mapped, spatially and temporally, throughout the area of concern...
June 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29907740/single-breath-hold-photoacoustic-computed-tomography-of-the-breast
#18
Li Lin, Peng Hu, Junhui Shi, Catherine M Appleton, Konstantin Maslov, Lei Li, Ruiying Zhang, Lihong V Wang
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts...
June 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29907510/reducing-x-ray-imaging-for-proton-postmastectomy-chest-wall-patients
#19
Estelle Batin, Nicolas Depauw, Rachel B Jimenez, Shannon MacDonald, Hsiao-Ming Lu
PURPOSE: Proton postmastectomy radiation therapy (PMRT) patients are positioned daily using surface imaging with additional x-ray imaging for confirmation. This study aims to investigate whether weekly x-ray imaging with daily surface imaging, as performed for photon treatment, is sufficient to maintain PMRT patient positioning fidelity. METHODS AND MATERIALS: Calculated radiographic corrections and surface imaging residual setup errors were analyzed at the treatment angle for 28 PMRT patients (with and without breast implant, left and right sided)...
March 10, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907260/usefulness-of-the-twinkling-artifact-on-doppler-ultrasound-for-the-detection-of-breast-microcalcifications
#20
A Relea, J A Alonso, M González, C Zornoza, S Bahamonde, B E Viñuela, M B Encinas
OBJECTIVE: To determine whether the twinkling artifact on Doppler ultrasound imaging corresponds to microcalcifications previously seen on mammograms and to evaluate the usefulness of this finding in the ultrasound management of suspicious microcalcifications. MATERIAL AND METHODS: We used ultrasonography to prospectively examine 46 consecutive patients with groups of microcalcifications suspicious for malignancy identified at mammography, searching for the presence of the twinkling artifact to identify the microcalcifications...
June 12, 2018: Radiología
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