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https://www.readbyqxmd.com/read/29929185/spectral-domain-optical-coherence-tomography-allows-the-unification-of-clinical-decision-making-for-the-evaluation-of-choroidal-neovascularization-activity
#1
Cornelia Volz, Felix Grassmann, Roman Greslechner, David Arthur Märker, Patrick Peters, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD). PROCEDURES: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis)...
June 21, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29929173/influence-of-tranexamic-acid-on-cerebral-hemorrhage-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Beilei Huang, Qiusheng Xu, Ru Ye, Jun Xu
Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid on cerebral hemorrhage. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of tranexamic acid on cerebral hemorrhage were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies...
June 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929169/ultrasound-guided-posterior-quadratus-lumborum-block-for-postoperative-pain-after-laparoscopic-cholecystectomy-a-randomized-controlled-double-blind-study
#3
Korgün Ökmen, Burcu Metin Ökmen, Serra Topal
STUDY OBJECTIVE: Laparoscopic techniques are commonly used in surgical operations of the gallbladder. There are very few regional anesthesia methods used to achieve this goal. We aimed to investigate the effect of ultrasound-guided posterior quadratus lumborum block (QLB), administered bilaterally on pain scores after laparoscopic cholecystectomy operations. DESIGN: Prospective, double blind, randomized controlled clinical trial. SETTING: Single-institution, tertiary hospital...
June 18, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29929113/predicting-suicidal-behaviour-after-first-episode-of-non-affective-psychosis-the-role-of-neurocognitive-functioning
#4
M Canal-Rivero, J D López-Moríñigo, E Setién-Suero, M Ruiz-Veguilla, J L Ayuso-Mateos, R Ayesa-Arriola, B Crespo-Facorro
BACKGROUND: Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period...
June 18, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29929109/refractory-epilepsy-in-preschool-children-with-tuberous-sclerosis-complex-early-surgical-treatment-and-outcome
#5
Martine Fohlen, Delphine Taussig, Sarah Ferrand-Sorbets, Mathilde Chipaux, Nathalie Dorison, Olivier Delalande, Georg Dorfmüller
PURPOSE: Epilepsy surgery has been shown to be effective in treating focal epilepsy related to tuberous sclerosis complex (TSC). We analyzed the advantage of early surgical management in terms of seizure frequency and development. METHOD: We retrospectively studied the 15 patients younger than 6 years who underwent resective surgery between 2006 and 2016. Fourteen of them had invasive monitoring while the 15th was operated on under corticography. RESULTS: Epilepsy began before 5 months of age in all patients...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929092/adjuvant-chemotherapy-and-postoperative-radiotherapy-in-high-risk-soft-tissue-sarcoma-patients-defined-by-biological-risk-factors-a-scandinavian-sarcoma-group-study-ssg-xx
#6
Kirsten Sundby Hall, Øyvind S Bruland, Bodil Bjerkehagen, Olga Zaikova, Jacob Engellau, Oskar Hagberg, Lina Hansson, Hans Hagberg, Marie Ahlström, Heidi Knobel, Karin Papworth, Maja Zemmler, Dorota Goplen, Henrik C F Bauer, Mikael Eriksson
PURPOSE: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been reported to be about 50% without adjuvant chemotherapy. METHODS: High-risk STS was defined as high-grade morphology (according to the Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC] grade II-III) and either vascular invasion or at least two of the following criteria: tumour size ≥8...
June 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29929087/an-effort-expenditure-perspective-on-cancer-related-fatigue
#7
Tamara E Lacourt, Elisabeth G Vichaya, Carmen Escalante, Ellen F Manzullo, Brandon Gunn, Kenneth R Hess, Cobi J Heijnen, Robert Dantzer
While fatigue is the most common and debilitating side effect of cancer and cancer treatment it is still poorly understood, partly because it is usually characterized by patient-reported outcomes. As patient-reports are inherently subjective, behavioral correlates of the symptom of fatigue are needed to increase our understanding of the symptom. We focused on motivational effort expenditure as a crucial behavior in cancer-related fatigue, using a validated computerized task contrasting high effort/high reward and low effort/low reward choices under different probabilities of success...
June 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29929030/comparative-utility-of-dynamic-and-static-imaging-in-the-management-of-lumbar-spondylolisthesis
#8
Vibhu Krishnan Viswanathan, Jeff Hatef, Sina Aghili, Amy Minnema, H Francis Farhadi
OBJECTIVE: Segmental instability is traditionally investigated with flexion and extension (F/E) X-rays. We sought to determine whether motion between upright and supine (U/S) views can serve as an alternative sensitive diagnostic tool that predicts similar outcomes. METHODS: Ambispective collection of data was performed for 222 consecutive patients that underwent transforaminal lumbar interbody fusion (TLIF). Patients were divided into either Group 1 (≥3 mm spondylolisthesis difference between F/E X-rays) or Group 2 (≥3 mm spondylolisthesis difference between U/S imaging and otherwise not meeting Group 1 criteria)...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929027/percutaneous-pedicle-screw-fixation-with-bone-cement-augmentation-under-epidural-anesthesia-for-the-treatment-of-k%C3%A3-mmell-s-disease-at-extremely-old-age-a-case-report
#9
Keun Lee, Nitin Adsul, Hyeun-Sung Kim, Yong-Hun Pee, Kwang Lae Lee, Il-Tae Jang
BACKGROUND: In cases of Kümmell's disease without neuro deficit, percutaneous vertebroplasty or Kyphoplasty have achieved short-term favorable outcomes. In the long term, re-collapse of the augmented vertebral body and aggravation of the kyphosis at the index level is often reported. On the other hand, owing to medical comorbidities, the elderly are often not suited for extensive open spine surgery under general anesthesia. CASE DESCRIPTION: A 95-year-old man presented with a one-month history of intractable back pain and gait disturbance...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929026/surgical-treatment-of-middle-cerebral-artery-aneurysms-the-aneurysm-location-and-size-ratio-as-risk-factors-for-the-neurological-worsening-and-ischemic-complications
#10
Hidetoshi Matsukawa, Hiroyasu Kamiyama, Takanori Miyazaki, Yu Kinoshita, Nakao Ota, Kosumo Noda, Takaharu Shonai, Osamu Takahashi, Sadahisa Tokuda, Rokuya Tanikawa
OBJECT: Regardless of acceptable surgical results of middle cerebral artery aneurysms (MCAs), MCA territory infarction (MCATI) is still one of major problems needing to be solved to archive the better outcome. Authors aimed to investigate the MCATI in patients with surgically treated MCA aneurysms. METHODS: The data of 286 consecutive patients with 322 MCA aneurysms was retrospectively evaluated. The aneurysm location was classified into the early frontal cortical branch (EFCB), early temporal cortical branch (ETCB), bi- or trifurcation (M1-2), and distal aneurysms on the insular, opercular, or cortical segments of MCA (distal MCA)...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929019/the-rehabilitation-of-advanced-heart-failure-patients-after-left-ventricular-assist-device-a-narrative-review
#11
REVIEW
Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29928948/single-dose-daily-fractionated-is-not-inferior-to-twice-a-day-fractionated-total-body-irradiation-prior-to-allogeneic-stem-cell-transplantation-for-acute-leukemia-a-useful-practice-simplification-resulting-from-the-sarasin-study
#12
Yazid Belkacemi, Myriam Labopin, Sebastian Giebel, Norbert Claude Gorin, Gokoulakrichenane Loganadane, Leszek Miszczyk, Mauricette Michallet, Gerard Socié, Nicolaas Pm Schaap, Jan J Cornelissen, Ibrahim Yakoub-Agha, Emmanuelle Polge, Mohamad Mohty, Arnon Nagler
PURPOSE: Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. The standard technique consists of 12Gy in 6 fractions over 3 days. The SARASIN study aimed to compare standard-fractionation to one-daily fractionation prior to transplant in leukemia. MATERIAL AND METHODS: We retrospectively compared TBI regimens delivered in 2993 patients from the EBMT database, transplanted between 2000 and 2014 for acute lymphoblastic (ALL, n=1729) or acute myelogenous (AML, n=1264) leukemia...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29928936/multiband-fmri-as-a-plausible-time-saving-technique-for-resting-state-data-acquisition-study-on-functional-connectivity-mapping-using-graph-theoretical-measures
#13
K A Smitha, K M Arun, P G Rajesh, Suresh E Joel, Ramesh Venkatesan, Bejoy Thomas, Chandrasekharan Kesavadas
BACKGROUND AND OBJECTIVES: Ensuring patient comfort and compliance by emphasizing reduced time frame for image acquisition, without compromising image quality is the key aspect with functional MRI examination. Multiband resting state fMRI (MB-rsfMRI) is a fairly new technique that potentially shortens MR image acquisition time by providing increased number of time points. The study aims to compare signal characteristics as well as the functional connectivity using conventional resting-state fMRI (rsfMRI) with that of MB-rsfMRI technique...
June 18, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29928924/navigate-ii-randomized-double-blind-trial-of-the-exhalation-delivery-system-with-fluticasone-eds-flu-for-nasal-polyposis
#14
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928921/paucigranulocytic-asthma-the-uncoupling-of-airway-obstruction-from-inflammation
#15
Omar Tliba, Reynold A Panettieri
Among patients with asthma, heterogeneity exists regarding the pattern of airway inflammation and response to treatment, prompting the necessity of recognizing specific phenotypes. Based on the analysis of inflammatory cell count in induced sputum, patients with asthma can be classified in four unique phenotypes; eosinophilic, neutrophilic, mixed granulocytic, and paucigranulocytic asthma (PGA). PGA is an asthma phenotype with no evidence of elevated numbers of eosinophils or neutrophils in sputum or blood, and in which anti-inflammatory therapies are ineffective in controlling symptoms...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928869/focal-cryoballoon-versus-radiofrequency-ablation-of-dysplastic-barrett-s-esophagus-impact-on-treatment-response-and-postprocedural-pain
#16
Sanne N van Munster, Anouk Overwater, Rehan Haidry, Raf Bisschops, Jacques J G H M Bergman, Bas L A M Weusten
BACKGROUND AND AIMS: Radiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE), but associated with significant postprocedural pain. Alternatively, balloon-based focal cryoablation (CRYO) has recently been developed, which preserves the extracellular matrix and might therefore be less painful. Although data for CRYO are still limited, uncontrolled studies suggest comparable safety and efficacy to RFA in eradicating limited BE areas. Therefore, secondary endpoints such as pain might become decisive for treatment selection...
June 18, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29928853/surgical-outcome-in-adolescents-and-adults-with-anomalous-left-coronary-artery-from-pulmonary-artery
#17
Xin Yuan, Bin Li, Hansong Sun, Yan Yang, Hong Meng, Liang Xu, Yunhu Song, Jianping Xu
BACKGROUND: It is uncertain with the outcomes of different repair strategies of anomalous left coronary artery from pulmonary artery (ALCAPA) in adolescent and adult patients. The long-term outcomes of reimplantation and Takeuchi repair were compared in this study. METHODS: We conducted a retrospective review of data collected from patients receiving ALCAPA repair at our institute from January 2005 to December 2016. Short- and long-term outcomes of re-implantation and Takeuchi repair were compared...
June 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29928849/do-antiplatelet-drugs-increase-the-risk-of-bleeding-after-dental-implant-surgery-a-case-and-crossover-study
#18
Reza Tabrizi, Isa Khaheshi, Afshin Hoseinzadeh, Babak Rezvanpour, Shervin Shafee
PURPOSE: Cessation versus continuation of antiplatelet drugs in patients undergoing dental implant surgery is a controversial issue. The present study evaluated postoperative bleeding during and after dental implant surgery in patients taking aspirin (ASA) or clopidogrel. MATERIAL AND METHODS: The present study is a case-and-crossover study. Patients who were using antiplatelet drugs and receiving 2 bilateral dental implants in the posterior region of the mandible were studied...
May 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#19
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29928832/amalgam-alternatives-cost-effectiveness-and-value-of-information-analysis
#20
F Schwendicke, G Göstemeyer, M Stolpe, J Krois
We aimed to assess the cost-effectiveness of amalgam alternatives-namely, incrementally placed composites (IComp), composites placed in bulk (BComp), and glass ionomer cements (GIC). In a sensitivity analysis, we also included composite inlays (CompI) and incrementally placed bulk-fills (IBComp). Moreover, the value of information (VOI) regarding the effectiveness of all strategies was determined. A mixed public-private-payer perspective in the context of Germany was adopted. Bayesian network meta-analyses were performed to yield effectiveness estimates (relative risk [RR] of failure)...
June 1, 2018: Journal of Dental Research
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