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https://www.readbyqxmd.com/read/28822346/comparative-study-of-single-combination-use-of-huang-lian-jie-du-decoction-and-berberine-on-their-protection-on-sepsis-induced-acute-liver-injury-by-nmr-metabolic-profiling
#1
Yan Lv, Junsong Wang, Dingqiao Xu, Shanting Liao, Pei Li, Qian Zhang, Minghua Yang, Lingyi Kong
Sepsis is a serious clinical disease with a high mortality rate all around the world. Liver organ dysfunction is an important sign for the severity and outcome of sepsis in patients. In this study, (1)H NMR-based metabolomics approach and biochemical assays were applied to investigate the metabolic profiling for cecal ligation and puncture (CLP) induced acute liver injury, the therapeutical effect of single/combination use of Huang-Lian-Jie-Du decoction (HLJDD) and berberine, and the interaction of them. Metabolomics analysis revealed significant perturbations in livers of septic rats, which could be ameliorated by HLJDD, berberine and their combination treatment...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28822277/the-role-of-anxiety-sensitivity-in-reactivity-to-trauma-cues-in-treatment-seeking-adults-with-substance-use-disorders
#2
R Kathryn McHugh, Kim L Gratz, Matthew T Tull
BACKGROUND: Exposure to traumatic events and posttraumatic stress disorder (PTSD) are common among individuals with substance use disorders (SUDs). Although the presence of trauma exposure and/or PTSD among those with SUDs is associated with a range of negative outcomes, much remains to be understood about the factors contributing to these outcomes. Anxiety sensitivity (the tendency to respond fearfully to the signs and symptoms of anxiety) has been linked to greater PTSD symptoms and the use of substances to cope with PTSD symptoms, and is a promising factor for understanding the negative outcomes associated with co-occurring PTSD and SUDs...
July 31, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28822255/malnutrition-in-postacute-geriatric-care-basic-espen-diagnosis-and-etiology-based-diagnoses-analyzed-by-length-of-stay-in-hospital-mortality-and-functional-rehabilitation-indexes
#3
Dolores Sánchez-Rodríguez, Ester Marco, Cédric Annweiler, Natalia Ronquillo-Moreno, Andrea Tortosa, Olga Vázquez-Ibar, Ferran Escalada, Xavier Duran, Josep M Muniesa
OBJECTIVE: To determine the relationships between malnutrition and nutrition-related conditions according to the European Society of Clinical Nutrition and Metabolism (ESPEN) consensus and guidelines and clinical outcomes in postacute rehabilitation. METHODS: Of 102 eligible inpatients, 95 (84.5 years old, 63.2% women) fulfilled inclusion criteria: aged ≥70 years, body mass index <30kg/m(2), admission for rehabilitation. Mini-Nutritional Assessment-Short Form (MNA-SF≤11) identified patients "at risk" and ESPEN basic and etiology based definitions were applied...
August 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28822254/a-systematic-review-of-hypertension-outcomes-and-treatment-strategies-in-older-adults
#4
REVIEW
Julienne K Kirk, Julie Allsbrook, Maggie Hansell, Emily M Mann
OBJECTIVE: To evaluate the literature regarding blood pressure control and management in older adult patient population over 70 years of age. METHODS: A literature search was conducted using PubMed and capturing the data from 2006 to 2016. Terms used included MeSH headings for hypertension/therapy and antihypertension agents. A systematic review of published studies was performed. Articles including older patients (average age 70 years or older) being treated for hypertension were included...
July 25, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28822240/statin-use-and-venous-thromboembolism-in-cancer-a-large-active-comparator-propensity-score-matched-cohort-study
#5
Sherif M El-Refai, Esther P Black, Val R Adams, Jeffery C Talbert, Joshua D Brown
BACKGROUND: Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS: Patients with newly diagnosed cancer were followed for up to one year in a healthcare claims database (2010-2013). Three treatment groups included statin users, non-statin cholesterol lowering medication users, and an untreated group with pre-existing indications for statin therapy (hyperlipidemia, diabetes, or heart disease)...
August 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28822239/ischemic-stroke-rates-decline-in-patients-with-atrial-fibrillation-as-anticoagulants-uptake-improves-a-swedish-cohort-study
#6
Natalia Mochalina, Nazim Isma, Peter J Svensson, Anders Själander, Maj Carlsson, Tord Juhlin, Mattias Wieloch
INTRODUCTION: The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. MATERIALS AND METHODS: Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011-2013 in primary and secondary care and receiving oral anticoagulants (n=4847), aspirin (n=2850) or no treatment (n=3766) in Skåne County, Sweden...
August 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28822231/preoperative-halo-gravity-traction-for-severe-thoracic-kyphoscoliosis-patients-from-tibet-radiographic-correction-pulmonary-function-improvement-nursing-and-complications
#7
Xiaojin Li, Liwen Zeng, Xiaoyin Li, Xuexia Chen, Caixia Ke
BACKGROUND This study investigated the outcomes of preoperative HGT as an adjunct treatment for severe thoracic kyphoscoliosis, its role in radiographic correction, and pulmonary function improvement, together with nursing strategy and incidence of complications. MATERIAL AND METHODS Eleven patients with a mean age of 18.8 years were retrospectively reviewed. Inclusion criteria were: patients with severe kyphoscoliosis (coronal Cobb angle and kyphosis angle ≥80°); duration of HGT ≥8 weeks; patients undergoing HGT for at least 12 h per day; traction weight no less than 40% of body weight; and patients not receiving physical therapies...
August 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28822226/perinatal-outcomes-after-previable-preterm-premature-rupture-of-membranes-before-24-weeks-of-gestation
#8
Verena Kiver, Vinzenz Boos, Anke Thomas, Wolfgang Henrich, Alexander Weichert
OBJECTIVE: A current descriptive assessment of perinatal outcomes in pregnancies complicated by previable preterm premature rupture of membranes (pPPROM) at <24 weeks of gestation, after expectant treatment. STUDY DESIGN: Maternal and short-term neonatal data were collected for patients with pPPROM. RESULTS: Seventy-three patients with 93 fetuses were hospitalized with pPPROM at 15-24 weeks' gestation. Among these patients, 27.4% (n=20) chose pregnancy termination, 27...
August 19, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28822212/comparison-of-start-and-salt-triage-methodologies-to-reference-standard-definitions-and-to-a-field-mass-casualty-simulation
#9
Salvatore Silvestri, Adam Field, Neal Mangalat, Tory Weatherford, Christopher Hunter, Zoe McGowan, Zachary Stamile, Trevor Mattox, Tanner Barfield, Aarian Afshari, George Ralls, Linda Papa
OBJECTIVES: We compared Sort, Assess, Lifesaving Intervention, Treatment/Transport (SALT) and Simple Triage and Rapid Treatment (START) triage methodologies to a published reference standard, and evaluated the accuracy of the START method applied by emergency medical services (EMS) personnel in a field simulation. DESIGN: Simulated mass casualty incident (MCI). Paramedics trained in START triage assigned each victim to green (minimal), yellow (delayed), red (immediate), or black (dead) categories...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822211/healthcare-students-interprofessional-critical-event-disaster-response-course
#10
Tae Eung Kim, Tamara Shankel, Ellen T Reibling, Jacqueline Paik, Dolores Wright, Michelle Buckman, Kathi Wild, Ehren Ngo, Alireza Hayatshahi, Lee H Nguyen, T Kent Denmark, Tamara L Thomas
OBJECTIVE: Numerous disasters confirm the need for critical event training in healthcare professions. However, no single discipline works in isolation and interprofessional learning is recognized as a necessary component. An interprofessional faculty group designed a learning curriculum crossing professional schools. DESIGN: Faculty members from four healthcare schools within the university (nursing, pharmacy, allied health, and medicine) developed an interdisciplinary course merging both published cross-cutting competencies for critical event response and interprofessional education competencies...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822205/comparison-of-effectiveness-of-two-different-artemisinin-based-combination-therapies-in-an-area-with-high-seasonal-transmission-of-malaria-in-burkina-faso
#11
Paul Sondo, Karim Derra, Seydou Diallo Nakanabo, Zekiba Tarnagda, Adama Kazienga, Innocent Valea, Herman Sorgho, Jean-Bosco Ouédraogo, Tinga Robert Guiguemdé, Halidou Tinto
In Sahelian countries such as Burkina Faso, malaria transmission is seasonal with a high incidence of transmission during the rainy season. This study aimed to compare the effectiveness of the two recommended treatments (Artemether-Lumefantrine and Artesunate-Amodiaquine) for uncomplicated malaria in Burkina Faso regarding this seasonal variation of malaria transmission. This is part of a randomized open label trial comparing the effectiveness and safety of Artemether-Lumefantrine versus Artesunate-Amodiaquine according to routine practice in Nanoro...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28822119/five-questions-answered-a-review-of-autologous-hematopoietic-stem-cell-transplantation-for-the-treatment-of-multiple-sclerosis
#12
REVIEW
Harold L Atkins, Mark S Freedman
Multiple sclerosis (MS) is thought to be an autoimmune disease targeting the central nervous system leading to demyelination, and axonal and neuronal damage, resulting in progressive disability. More intensive therapies such as immunodepletion with hematopoietic stem-cell rescue are being used at a time prior to patients becoming irreversibly disabled. Over the last 15 years, there has been a shift away from using autologous hematopoietic stem-cell transplants (aHSCT) to treat patients with progressive MS, towards treating those with active inflammation and relapses...
August 18, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#13
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28822109/consumer-attitudes-towards-the-establishment-of-a-national-australian-familial-cancer-research-database-by-the-inherited-cancer-connect-iccon-partnership
#14
Laura Forrest, Gillian Mitchell, Letitia Thrupp, Lara Petelin, Kate Richardson, Lyon Mascarenhas, Mary-Anne Young
Clinical genetics units hold large amounts of information which could be utilised to benefit patients and their families. In Australia, a national research database, the Inherited Cancer Connect (ICCon) database, is being established that comprises clinical genetic data held for all carriers of mutations in cancer predisposition genes. Consumer input was sought to establish the acceptability of the inclusion of clinical genetic data into a research database. A qualitative approach using a modified nominal group technique was used to collect data through consumer forums conducted in three Australian states...
August 18, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28822102/effect-of-a-patient-specific-minimum-activity-in-stress-myocardial-perfusion-imaging-using-czt-spect-prognostic-value-radiation-dose-and-scan-outcome
#15
J D van Dijk, N M Borren, M Mouden, J A van Dalen, J P Ottervanger, P L Jager
BACKGROUND: SPECT Myocardial perfusion imaging (MPI) is associated with a relatively high radiation burden and decreasing image quality in heavy patients. Patient-specific low-activity protocols (PLAPs) are suggested but follow-up data is lacking. Our aim was to compare the use of a standard fixed-activity protocol (FAP) with a PLAP in cadmium zinc telluride (CZT)-SPECT MPI. METHODS: We retrospectively included 1255 consecutive patients who underwent CZT-SPECT stress-optional rest MPI...
August 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28822064/evolution-of-29-anthropometric-nutritional-and-cardiometabolic-parameters-among-morbidly-obese-adolescents-2-years-post-sleeve-gastrectomy
#16
Wahiba Elhag, Walid El Ansari, Sama Abdulrazzaq, Ali Abdullah, Mohamed Elsherif, Israa Elgenaied
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a popular treatment for adolescent morbid obesity. Research on LSG outcomes among adolescents assessed a narrow range of anthropometric, nutritional, or cardiometabolic parameters, leading to an incomplete picture of these changes. We examined a wide variety of anthropometric, nutritional, and cardiometabolic parameters among adolescents before and after LSG. METHODS: We retrospectively reviewed medical charts of all obese adolescents who underwent LSG at Hamad Medical Corporation, Qatar, between January 2011 and June 2015 (N = 102)...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28822056/patient-reported-outcomes-in-myelodysplastic-syndromes-and-mds-mpn-overlap-syndromes-stepping-onto-the-stage-with-changing-times
#17
REVIEW
Sagar S Patel, Aaron T Gerds
Quality of life (QOL) and symptom burden are important measures captured by patient-reported outcomes (PROs). Myelodysplastic and myelodysplastic/myeloproliferative (MDS/MPN) neoplasm overlap syndromes are notable for significant morbidity and mortality, including a wide spectrum of physical and psychosocial effects. Thus, the development and application of PROs can provide meaningful information to facilitate communication and assist in follow up care. Disease-specific measures can more accurately reflect the full breadth of functional restrictions and symptoms...
August 18, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28822055/social-inequalities-in-children-s-oral-health-related-quality-of-life-the-generation-r-study
#18
Lea Kragt, Eppo B Wolvius, Hein Raat, Vincent W V Jaddoe, Edwin M Ongkosuwito
PURPOSE: Oral health-related quality of life (OHRQoL) is the most important patient-reported outcome measure in oral health research. The purpose of the present research was to study the association of family socioeconomic position (SEP) with children's OHRQoL. METHODS: This cross-sectional study was embedded in the Generation R Study, a population-based cohort study conducted in Rotterdam, The Netherlands. For the present study, OHRQoL was assessed of 3871 ten-year old children...
August 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28822052/bariatric-surgery-worldwide-baseline-demographic-description-and-one-year-outcomes-from-the-second-ifso-global-registry-report-2013-2015
#19
Richard Welbourn, Dimitri J Pournaras, John Dixon, Kelvin Higa, Robin Kinsman, Johan Ottosson, Almino Ramos, Bart van Wagensveld, Peter Walton, Rudolf Weiner, Natan Zundel
BACKGROUND: Five International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) surveys since 1998 have estimated the volume and type of bariatric surgery being done in constituent member countries. These reports did not include baseline demographic descriptions. METHODS: An IFSO Global Registry pilot project in 2014 demonstrated that it was possible to amalgamate large numbers of individual patient data from different local and national database systems...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28822018/the-prevalence-of-growth-hormone-deficiency-in-survivors-of-subarachnoid-haemorrhage-results-from-a-large-single-centre-study
#20
Sumithra Giritharan, Joanna Cox, Calvin J Heal, David Hughes, Kanna Gnanalingham, Tara Kearney
OBJECTIVE: The variation in reported prevalence of growth hormone deficiency (GHD) post subarachnoid haemorrhage (SAH) is mainly due to methodological heterogeneity. We report on the prevalence of GHD in a large cohort of patients following SAH, when dynamic and confirmatory pituitary hormone testing methods are systematically employed. DESIGN: In this cross-sectional study, pituitary function was assessed in 100 patients following SAH. Baseline pituitary hormonal profile measurement and glucagon stimulation testing (GST) was carried out in all patients...
August 18, 2017: Pituitary
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