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https://www.readbyqxmd.com/read/29692001/all-cause-and-cause-specific-mortality-in-granulomatosis-with-polyangiitis-a-population-based-study
#1
Ju Ann Tan, Hyon K Choi, Hui Xie, Eric C Sayre, John M Esdaile, J Antonio Aviña-Zubieta
OBJECTIVE: To investigate all-cause and cause-specific mortality in patients with newly diagnosed granulomatosis with polyangiitis (GPA) between two calendar time periods, 1997-2004 and 2005-2012. METHODS: Using an administrative health database, we compared all incident cases of GPA to non-GPA controls matched based on sex, age and entry time. Study cohorts were divided into two sub-groups based on the year of diagnosis (i.e., early cohort 1997-2004 and late cohort 2005-2012)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29691998/a-novel-method-to-combine-assessment-of-benefit-and-harm-omeract-3x3-methodology-applied-to-two-active-comparator-trials
#2
Maarten Boers, Jasvinder A Singh, Stacey S Cofield, S Louis Bridges, Larry W Moreland, James R O'Dell, Hongsheng Wu, Sarah Leatherman, Jeffrey R Curtis
INTRODUCTION: The Outcome Measures in Rheumatology (OMERACT) '3x3' method analyzes the occurrence of benefit and harm simultaneously at the individual patient level. We applied this method to two recent rheumatoid arthritis (RA) trial datasets. METHODS: Treatment of Early Aggressive RA (TEAR) and the RA Comparison of Active Therapies (RACAT) randomized trial outcomes for safety were defined according to OMERACT as no events, non-serious events, and serious events...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29691976/time-together-a-nursing-intervention-in-psychiatric-inpatient-care-feasibility-and-effects
#3
Jenny Molin, Britt-Marie Lindgren, Ulla Hällgren Graneheim, Anders Ringnér
The facilitation of quality time between patients and staff in psychiatric inpatient care is useful to promote recovery and reduce stress experienced by staff. However, interventions are reported to be complex to implement and are poorly described in the literature. This multisite study aimed to evaluate the feasibility and effects of the nursing intervention Time Together, using mixed methods. Data consisted of notes from participant observations and logs to evaluate feasibility, and questionnaires to evaluate effects...
April 25, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29691974/aboriginal-experiences-of-cancer-and-care-coordination-lessons-from-the-cancer-data-and-aboriginal-disparities-candad-narratives
#4
Rachel Reilly, Jasmine Micklem, Paul Yerrell, David Banham, Kim Morey, Janet Stajic, Marion Eckert, Monica Lawrence, Harold B Stewart, Alex Brown
BACKGROUND: Aboriginal people with cancer experience worse outcomes than other Australians for a range of complex and interrelated reasons. A younger age at diagnosis, higher likelihood of more advanced cancer or cancer type with poorer prognosis, geographic isolation and cultural and language diversity mean that patient pathways are potentially more complex for Aboriginal people with cancer. In addition, variation in the quality and acceptability of care may influence cancer outcomes...
April 24, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29691971/hydroxychloroquine-may-be-associated-with-reduced-risk-of-coronary-artery-diseases-in-patients-with-rheumatoid-arthritis-a-nationwide-population-based-cohort-study
#5
Yao-Min Hung, Yu-Hsun Wang, Lichi Lin, Paul Yung Pou Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
OBJECTIVES: The aim of this study was to determine whether hydroxychloroquine (HCQ) usage is associated with incidental risk of coronary artery diseases (CAD) in patients with rheumatoid arthritis (RA). METHODS: The Longitudinal Health Insurance Database in Taiwan was used. The study cohort comprised of 1104 newly diagnosed RA patients between 2001-2010, and patients were followed until 31 December 2011. Patients with history of CAD before RA diagnosis were excluded...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691960/genexpert-mtb-rif-for-rapid-diagnosis-and-rifampin-resistance-detection-of-endobronchial-tuberculosis
#6
Qin Zhang, Qing Zhang, Bing-Qi Sun, Chang Liu, An-Na Su, Xiao-Han Wang, Na Liu, Juan Zhang, Jian Kang, Gang Hou
BACKGROUND AND OBJECTIVE: Delayed diagnosis and treatment of tuberculosis (TB) contribute to poor outcomes, especially for endobronchial TB (EBTB), which typically leads to tracheobronchial stenosis. Finding rapid and accurate diagnostic tools for EBTB is crucial. GeneXpert Mycobacterium tuberculosis (MTB)/rifampin (RIF) was recommended by the World Health Organization (WHO) as a standard molecular biological diagnostic technique for MTB. The aim of this study was to evaluate the efficacy of GeneXpert MTB/RIF for diagnosing EBTB and for evaluating RIF resistance...
April 24, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29691959/the-relationship-between-social-support-treatment-interruption-and-treatment-outcome-in-patients-with-multidrug-resistant-tuberculosis-in-china-a-mixed-methods-study
#7
Jia Yin, Xiaomeng Wang, Lin Zhou, Xiaolin Wei
OBJECTIVE: Multidrug-resistant tuberculosis (MDR-TB) has been a major threat for successful TB control. We examined the relationship between social support and treatment outcomes in MDR-TB patients and evaluated barriers to social support. METHODS: Retrospective cohort study with MDR-TB patients enrolled in the Global Fund program between 1 January 2009 and 30 June 2014 in Zhejiang, China. We reviewed all MDR-TB patients' diagnoses and treatment outcomes. In-depth interviews were conducted with 10 community health workers and 10 patients...
April 24, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29691957/very-long-term-outcome-of-schizophrenia
#8
REVIEW
Jan Volavka, Jan Vevera
PURPOSE: The principal aim is to review recent data concerning the very long-term outcome of schizophrenia and schizophrenia spectrum disorders. We examine factors that influence outcome, including therapeutic interventions. METHOD: PubMed and Scopus databases were searched for papers published between 2008 and 2017 reporting on prospective studies of schizophrenia or schizophrenia spectrum with a follow-up period ≥5 years with adequate outcome information. Additional publications were found in reference lists and authors' reference libraries...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691955/pharmacist-led-discharge-medication-counselling-a-scoping-review
#9
REVIEW
Aline F Bonetti, Wálleri C Reis, Natália Fracaro Lombardi, Antonio M Mendes, Harli Pasquini Netto, Inajara Rotta, Fernando Fernandez-Llimos, Roberto Pontarolo
RATIONALE, AIMS, AND OBJECTIVES: Discharge medication counselling has produced improved quality of care and health outcomes, especially by reducing medication errors and readmission rates, and improving medication adherence. However, no studies have assembled an evidence-based discharge counselling process for clinical pharmacists. Thus, the present study aims to map the components of the pharmacist-led discharge medication counselling process. METHODS: We performed a scoping review by searching electronic databases (Pubmed, Scopus, and DOAJ) and conducting a manual search to identify studies published up to July 2017...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29691950/adapting-evidence-based-clinical-practice-guidelines-at-university-teaching-hospitals-a-model-for-the-eastern-mediterranean-region
#10
Yasser S Amer, Hayfaa A Wahabi, Manal M Abou Elkheir, Ghada A Bawazeer, Shaikh M Iqbal, Maher A Titi, Aishah Ekhzaimy, Khalid A Alswat, Rasmieh A Alzeidan, Lubna A Al-Ansary
RATIONALE, AIMS, AND OBJECTIVES: Clinical practice guidelines (CPGs) are significant tools for evidence-based health care quality improvement. The CPG program at King Saud University was launched as a quality improvement program to fulfil the international accreditation standards. This program was a collaboration between the Research Chair for Evidence-Based Healthcare and Knowledge Translation and the Quality Management Department. This study aims to develop a fast-track method for adaptation of evidence-based CPGs and describe results of the program...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29691885/competence-and-frequency-of-provision-of-spiritual-care-by-nurses-in-the-netherlands
#11
Annemieke Vogel, Annemiek E Schep-Akkerman
BACKGROUND: Spiritual care to patients is important for their well-being, and nurses do have a crucial role in it. Previous research focused on self-assessed competence in providing spiritual care, but little is known about the actual provision. The aims of this study were as follows: (i) to evaluate how often nurses provide spiritual care, (ii) if or which association there is between self-assessed competency and provision of spiritual care, and (iii) to study which factors do have influence on delivering spiritual care...
April 25, 2018: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29691863/population-based-study-of-mortality-and-major-amputation-following-lower-limb-revascularization
#12
K Heikkila, I M Loftus, D C Mitchell, A S Johal, S Waton, D A Cromwell
BACKGROUND: The aim of this study was to estimate separate risks of major lower limb amputation and death following revascularization for peripheral artery disease (PAD) using competing risks analysis. METHODS: Routinely collected data from Hospital Episode Statistics (HES) were used to identify patients who underwent endovascular or open lower limb revascularization for PAD in England from 2005 to 2015. The primary outcomes were major lower limb amputation and death within 5 years of revascularization...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691839/gene-expression-profiles-for-a-prognostic-immunoscore-in-gastric-cancer
#13
D Zeng, R Zhou, Y Yu, Y Luo, J Zhang, H Sun, J Bin, Y Liao, J Rao, Y Zhang, W Liao
BACKGROUND: Increasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established. The aim was to develop an immune signature, based on the cellular composition of the immune infiltrate inferred from bulk tumour transcriptomes, to improve the prognostic predictions of gastric cancer...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691809/standardization-of-simple-auxiliary-method-beneficial-to-total-endoscopic-thyroidectomy-on-patients-with-ptc-based-on-retrospective-study-of-356-cases
#14
Shouyi Yan, Wenxin Zhao, Bo Wang, Liyong Zhang
OBJECTIVE: Total endoscopic thyroidectomy (TET) is paid increasing attention to by patients, especially those with thyroid carcinoma. The aim of this study is to evaluate the clinic feasibility of standardization of simple auxiliary method (SOSAM) involved in operating bed adjustment, location of skin traction points and thyroid retractor points for the TET via bilateral breast approach. METHODS: A retrospective study was performed on 356 patients with thyroid carcinoma, who had undergone the TET...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691782/cost-effectiveness-of-aspirin-adherence-for-secondary-prevention-of-cardiovascular-events
#15
Laurence M Djatche, Stefan Varga, Robert D Lieberthal
BACKGROUND: Suboptimal adherence to aspirin therapy for secondary prevention of cardiovascular (CV) events is an important public health problem. Prior studies have demonstrated non-adherent patients are at higher risk of experiencing CV events. OBJECTIVES: This study aimed to estimate the clinical and economic outcomes of aspirin non-adherence in patients with a prior primary CV event. METHODS: We developed a Markov model to estimate the cost-effectiveness of aspirin adherence from a generic US managed care payer perspective over a 5-year time horizon...
April 24, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29691776/management-of-glioblastoma-at-safety-net-hospitals
#16
Michael G Brandel, Robert C Rennert, Christian Lopez Ramos, David R Santiago-Dieppa, Jeffrey A Steinberg, Reith R Sarkar, Arvin R Wali, J Scott Pannell, James D Murphy, Alexander A Khalessi
BACKGROUND: Safety-net hospitals (SNHs) provide disproportionate care for underserved patients. Prior studies have identified poor outcomes, increased costs, and reduced access to certain complex, elective surgeries at SNHs. However, it is unknown whether similar patterns exist for the management of glioblastoma (GBM). We sought to determine if patients treated at HBHs receive equitable care for GBM, and if safety-net burden status impacts post-treatment survival. METHODS: The National Cancer Database was queried for GBM patients diagnosed between 2010 and 2015...
April 24, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29691775/cranial-nerve-outcomes-after-primary-stereotactic-radiosurgery-for-symptomatic-skull-base-meningiomas
#17
Andrew Faramand, Hideyuki Kano, Ajay Niranjan, Stephen A Johnson, Mohab Hassib, Kyung-Jae Park, Yoshio Arai, John C Flickinger, L Dade Lunsford
OBJECTIVE: To evaluate cranial nerve (CN) outcomes after primary stereotactic radiosurgery (SRS) for petroclival, cavernous sinus, and cerebellopontine angle meningiomas. METHODS: From our prospectively maintained database of 2022 meningioma patients who underwent Leksell stereotactic radiosurgery (SRS) during a 30-year interval, we found 98 patients with petroclival, 242 with cavernous sinus, and 55 patients with cerebellopontine angle meningiomas. Primary radiosurgery was performed in 245 patients...
April 24, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29691773/etelcalcetide-for-treating-secondary-hyperparathyroidism-an-evidence-review-group-evaluation-of-a-nice-single-technology-appraisal
#18
Micah Rose, Jonathan Shepherd, Petra Harris, Karen Pickett, Joanne Lord
The manufacturer of the calcimimetic drug etelcalcetide was invited to make an evidence submission as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) programme. Within this submission, they reported evidence on the clinical and cost effectiveness of etelcalcetide for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on haemodialysis. The Southampton Health Technology Assessments Centre (SHTAC), part of the Wessex Institute at the University of Southampton, was the independent Evidence Review Group (ERG) commissioned to appraise the company's submission...
April 25, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29691772/evaluation-of-quality-of-life-in-patients-with-axial-spondyloarthritis-and-its-association-with-disease-activity-functionality-mobility-and-structural-damage
#19
Clementina López-Medina, Juan L Garrido-Castro, Juan Castro-Jiménez, Cristina González-Navas, Jerusalem Calvo-Gutiérrez, M Carmen Castro-Villegas, Rafaela Ortega-Castro, Alejandro Escudero-Contreras, Pilar Font-Ugalde, Eduardo Collantes-Estévez
To evaluate quality of life (QoL) in patients with axial spondyloarthritis (axSpA) and its association with disease activity, functionality, structural damage, and spinal mobility, using patient-reported outcomes. This was an observational, cross-sectional, and single-center study in which 100 consecutive patients with axSpA were included. We obtained from all patients' sociodemographic data and values related to disease activity, functionality, structural damage, mobility, and quality of life. The Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) was considered as the primary outcome...
April 24, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29691768/skin-cancer-following-solid-organ-transplantation-a-review-of-risk-factors-and-models-of-care
#20
REVIEW
Matthew D Howard, John C Su, Alvin H Chong
The number of solid organ transplants has been increasing annually worldwide. Advances in transplantation surgery and community awareness of organ donation have been key contributors. Combined with increased understanding of immunosuppression, there are a growing number of solid organ transplant recipients in the community as a result of improved long-term outcomes. There remains a high incidence of deaths worldwide post-transplant due to non-melanoma skin cancer (NMSC), which has greater morbidity and mortality in this population than in the general community...
April 24, 2018: American Journal of Clinical Dermatology
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