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https://www.readbyqxmd.com/read/29667606/applying-a-new-computer-aided-detection-scheme-generated-imaging-marker-to-predict-short-term-breast-cancer-risk
#1
Seyedehnafiseh Mirniaharikandehei, Alan B Hollingsworth, Bhavika Patel, Morteza Heidari, Hong Liu, Bin Zheng
This study aims to investigate the feasibility of identifying a new quantitative imaging marker based on false-positives generated by computer-aided detection (CAD) scheme to help predict short-term breast cancer risk. An image dataset including four view mammograms acquired from 1,044 women was retrospectively assembled. All mammograms were originally interpreted as negative by radiologists. In the next subsequent mammography screening, 402 women were diagnosed with breast cancer and 642 remained negative...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667279/baicalein-disturbs-the-morphological-plasticity-and-motility-of-breast-adenocarcinoma-cells-depending-on-the-tumor-microenvironment
#2
Takeshi Terabayashi, Katsuhiro Hanada, Kou Motani, Hidetaka Kosako, Mami Yamaoka, Toshihide Kimura, Toshimasa Ishizaki
During tumor invasion, cancer cells change their morphology and mode of migration based on communication with the surrounding environment. Numerous studies have indicated that paracrine interactions from non-neoplastic cells impact the migratory and invasive properties of cancer cells. Thus, these interactions are potential targets for anticancer therapies. In this study, we showed that the flavones member baicalein suppresses the motility of breast cancer cells that is promoted by paracrine interactions. First, we identified laminin-332 (LN-332) as a principle paracrine factor in conditioned medium from mammary epithelium-derived MCF10A cells that regulates the morphology and motility of breast adenocarcinoma MDA-MB-231 cells...
April 18, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29667003/chemical-genomics-reveals-inhibition-of-breast-cancer-lung-metastasis-by-ponatinib-via-c-jun
#3
Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang, Dong Wang
Metastasis is the leading cause of human cancer deaths. Unfortunately, no approved drugs are available for anti-metastatic treatment. In our study, high-throughput sequencing-based high-throughput screening (HTS2 ) and a breast cancer lung metastasis (BCLM)-associated gene signature were combined to discover anti-metastatic drugs. After screening of thousands of compounds, we identified Ponatinib as a BCLM inhibitor. Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models...
April 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29666991/frequency-and-characteristics-of-contralateral-breast-abnormalities-following-recall-at-screening-mammography
#4
Joost R C Lameijer, Angela Coolen, Adri C Voogd, Luc J Strobbe, Marieke W J Louwman, Dick Venderink, Vivian C Tjan-Heijnen, Lucien E M Duijm
PURPOSE: To determine the frequency and characteristics of contralateral, non-recalled breast abnormalities following recall at screening mammography. METHODS: We included a series of 130,338 screening mammograms performed between 1 January 2014 and 1 January 2016. During the 1-year follow-up, clinical data were collected for all recalls. Screening outcome was determined for recalled women with or without evaluation of contralateral breast abnormalities. RESULTS: Of 3,995 recalls (recall rate 3...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29666814/digital-chest-tomosynthesis-the-2017-updated-review-of-an-emerging-application
#5
REVIEW
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29665850/common-genetic-variation-and-novel-loci-associated-with-volumetric-mammographic-density
#6
Judith S Brand, Keith Humphreys, Jingmei Li, Robert Karlsson, Per Hall, Kamila Czene
BACKGROUND: Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained. METHODS: We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations with volumetric MD phenotypes (percent dense volume, absolute dense volume, and absolute nondense volume) were estimated using linear regression adjusting for age, body mass index, menopausal status, and six principal components...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29665706/the-efficacy-of-using-computer-aided-detection-cad-for-detection-of-breast-cancer-in-mammography-screening-a-systematic-review
#7
Emilie L Henriksen, Jonathan F Carlsen, Ilse Mm Vejborg, Michael B Nielsen, Carsten A Lauridsen
Background Early detection of breast cancer (BC) is crucial in lowering the mortality. Purpose To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD. Material and Methods PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665537/mass-detection-in-digital-breast-tomosynthesis-data-using-convolutional-neural-networks-and-multiple-instance-learning
#8
Mina Yousefi, Adam Krzyżak, Ching Y Suen
Digital breast tomosynthesis (DBT) was developed in the field of breast cancer screening as a new tomographic technique to minimize the limitations of conventional digital mammography breast screening methods. A computer-aided detection (CAD) framework for mass detection in DBT has been developed and is described in this paper. The proposed framework operates on a set of two-dimensional (2D) slices. With plane-to-plane analysis on corresponding 2D slices from each DBT, it automatically learns complex patterns of 2D slices through a deep convolutional neural network (DCNN)...
April 12, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29664916/is-periodontitis-a-risk-indicator-for-cancer-a-meta-analysis
#9
Stefano Corbella, Paolo Veronesi, Viviana Galimberti, Roberto Weinstein, Massimo Del Fabbro, Luca Francetti
BACKGROUND: The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. METHODS: Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis. RESULTS: Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies...
2018: PloS One
https://www.readbyqxmd.com/read/29663479/quantifying-rater-variation-for-ordinal-data-using-a-rating-scale-model
#10
Shiqi Zhang, Jørgen Holm Petersen
We present a model-based approach to the analysis of agreement between different raters in a situation where all raters have supplied ordinal ratings of the same cases in a sample. It is assumed that no "gold standard" is available. The model is an ordinal regression model with random effects-a so-called rating scale model. The model includes case-specific parameters that allow each case his or hers own level (disease severity). It also allows raters to have different propensities to score a given set of individuals more or less positively-the rater level...
April 16, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29663358/a-case-control-study-of-hiv-infection-and-cancer-in-the-era-of-antiretroviral-therapy-in-rwanda
#11
Tharcisse Mpunga, Ariana Znaor, F Regis Uwizeye, Aline Uwase, Cyprien Munyanshongore, Silvia Franceschi, Gary M Clifford
The aim of our study was to assess the association between HIV infection and cancer risk in Rwanda approximately a decade after the introduction of antiretroviral therapy (cART). All persons seeking cancer care at Butaro Cancer Center of Excellence (BCCOE) in Rwanda from 2012 to 2016 were routinely screened for HIV, prior to being confirmed with or without cancer (cases and controls, respectively). Cases were coded according to ICD-O-3 and converted to ICD10. Associations between individual cancer types and HIV were estimated using adjusted unconditional logistic regression...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29661602/automated-breast-ultrasound-interpretation-times-a-reader-performance-study
#12
Ashley I Huppe, Marc F Inciardi, Mark Redick, Melissa Carroll, Jennifer Buckley, Jacqueline D Hill, Jason B Gatewood
RATIONALE AND OBJECTIVES: This study aimed to determine the average time for breast radiologists of varied experience to interpret automated breast ultrasound (ABUS) examinations. MATERIALS AND METHODS: A reader performance study was conducted on female patients, with ACR BI-RADS 4 breast density classifications of C or D, who received both an ABUS screening examination and a digital mammogram from 2013 to 2014 at an academic institution. Three faculty breast radiologists with varied levels of ABUS experience (advanced, intermediate, novice) read all ABUS examinations, with interpretation times and final impressions (categorized as "normal" or "abnormal") recorded for each examination...
April 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29659598/reducing-health-inequalities-with-interventions-targeting-behavioral-factors-among-individuals-with-low-levels-of-education-a-rapid-review
#13
Andreas Vilhelmsson, Per-Olof Östergren
Individuals with low levels of education systematically have worse health than those with medium or high levels of education. Yet there are few examples of attempts to summarize the evidence supporting the efficacy of interventions targeting health-related behavior among individuals with low education levels, and a large part of the literature is descriptive rather than analytical. A rapid review was carried out to examine the impact of such interventions. Special attention was given to the relative impact of the interventions among individuals with low education levels and their potential to reduce health inequality...
2018: PloS One
https://www.readbyqxmd.com/read/29658110/prenatal-diethylstilbestrol-des-exposure-and-mammographic-density
#14
William C Strohsnitter, Kimberly A Bertrand, Rebecca Troisi, Christopher G Scott, Andrea L Cheville, Robert N Hoover, Julie R Palmer, Celine M Vachon
In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort of DES-exposed and unexposed women was assembled at the Mayo Clinic in 1975, and followed through 2012 as part of the National Cancer Institute's DES Follow-up Study. Mammographic density from 3,637 mammograms for 332 (222 DES-exposed, 110 unexposed) women in this cohort screened at the Mayo Clinic, Rochester between 1996 and 2015 were determined clinically using the Breast Imaging Reporting and Data System (BI-RADS)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29657941/investigation-of-frequency-distribution-of-breast-imaging-reporting-and-data-system-birads-classification-and-epidemiological-factors-related-to-breast-cancer-in-iran-a-7-year-study-2010-2016
#15
Mehri Sirous, Parisa Sotoodeh Shahnani, Amirmasoud Sirous
Background: The first cause of women mortality due to cancer is breast cancer. Mammography plays a central part in early detection of breast cancers. The screening methods can play a major role to reduce the morbidity and mortality rate due to this malignancy. We sought the basic data in this study on our population because knowing about the baseline data is apt and vital. Materials and Methods: In this study, data were collected from a questionnaire, contained baseline bio data information, and mammographic imaging of the patients came during 7 years...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29657610/detection-of-hepatocellular-carcinoma-by-tissue-resonance-interaction-method-trim
#16
Grzegorz Boryczka, Marek Hartleb, Małgorzata Janik
Introduction: Diagnosis of hepatocellular carcinoma (HCC) is considerably delayed, being frequently done in the non-curative stage of disease. The reason for delayed diagnosis is indolent course in early stages and/or unspecific symptoms indistinguishable from underlying cirrhosis. Hitherto methods used for screening of HCC have important limitations. TRIMprob is a non-invasive method, which showed utility in detection of cancers located in prostate, breast, or urinary bladder. Aim: To determine the diagnostic accuracy of TRIMprob in detecting HCC in cirrhotic liver...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29657543/association-of-abo-and-rh-blood-groups-with-breast-cancer
#17
Sultan Ayoub Meo, Faryal Suraya, Badar Jamil, Fwziah Al Rouq, Anusha Sultan Meo, Kamran Sattar, Mohammad Javed Ansari, Saleh A Alasiri
Objectives: The aim of this study was to determine the association of "ABO" and "Rhesus" blood groups with incidence of breast cancer. Methods: In this study, we identified 70 research documents from data based search engines including "PubMed", "ISI-Web of Knowledge", "Embase" and "Google Scholar". The research papers were selected by using the primary key-terms including "ABO blood type", "Rhesus" blood type and "breast cancer"...
November 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29657180/views-of-low-income-women-of-color-at-increased-risk-for-breast-cancer
#18
Emily E Anderson, Silvia Tejada, Richard B Warnecke, Kent Hoskins
Individual risk assessment (IRA) for breast cancer may increase adherence to risk-appropriate screening and prevention measures. However, knowledge gaps exist regarding how best to communicate IRA results and support women at increased risk in future health care decisions, in part because patients conceptualize and make meaning of risk differently from the medical community. Better understanding the views of low-income women of color identified as being at increased risk for breast cancer can inform efforts to conduct IRA in an ethical and respectful manner...
2018: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29656463/rural-health-networks-how-network-analysis-can-inform-patient-care-and-organizational-collaboration-in-a-rural-breast-cancer-screening-network
#19
Beth Prusaczyk, Julia Maki, Douglas A Luke, Rebecca Lobb
PURPOSE: Rural health networks have the potential to improve health care quality and access. Despite this, the use of network analysis to study rural health networks is limited. The purpose of this study was to use network analysis to understand how a network of rural breast cancer care providers deliver services and to demonstrate the value of this methodology in this research area. METHODS: Leaders at 47 Federally Qualified Health Centers and Rural Health Clinics across 10 adjacent rural counties were asked where they refer patients for mammograms or breast biopsies...
April 15, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29656222/prolactin-induced-protein-pip-is-a-potential-biomarker-for-early-stage-and-malignant-breast-cancer
#20
Anju Gangadharan, Themba Nyirenda, Kishan Patel, Nydia Jaimes-Delgadillo, Dominique Coletta, Takemi Tanaka, Ayal C Walland, Zena Jameel, Srinivasa Vedantam, Sittinon Tang, Ciaran Mannion, Grace Y Lee, Andre Goy, Andrew Pecora, K Stephen Suh
OBJECTIVES: Breast cancer (BC) is the second leading cause of cancer-related mortality in women. Bioinformatic analysis and expression screening showed that Prolactin Induced Protein (PIP) was differentially expressed in BC. The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
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