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amiodarone, atrial fibrillation

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https://www.readbyqxmd.com/read/27909490/effects-of-atrial-fibrillation-cardioversion-after-percutaneous-mitral-balloon-valvuloplasty-on-echocardiographic-left-and-right-atrial-functions
#1
Ayman Morttada Md, Aly Ramzy Md, Said Khaled Md, Amal Ayoub Md, Sameh Samir Md, Hossam Zaki Md
Amongst patients with mitral stenosis (MS), the most common complication is AF.Our study aimed at evaluating the effect of AF cardioversion after Percutaneous Mitral Balloon Valvuloplasty (PMBV) on echocardiographic atrial functions. The study included 34 patients with MS and AF, presenting to Ain-shams University hospitals, who underwent successful PMBV then randomized into 2 different groups according to AF management strategy. Group-I patients (n=16) received DC cardioversion after amiodarone infusion (within 24 hours post-PMBV) in addition to anticoagulation...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909477/sotalol-versus-amiodarone-in-treatment-of-atrial-fibrillation
#2
John Somberg Md, Janos Molnar Md
The availability of intravenous (IV) Sotalol has equalized the treatment options since both amiodarone and sotalol are available in both IV and oral formulations. A review of the efficacy of sotalol as compared to amiodarone both for conversion of atrial fibrillation (AF) and maintenance of normal sinus rhythm (NSR) following cardiac surgery was undertaken. Standard methods of meta-analysis were employed. Full text publications of clinical trials written in English that compared the efficacy of sotalol to amiodarone were included in the analysis...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27903390/-current-status-of-antiarrhythmic-drug-use-and-safety-assessment-in-chinese-patients-with-atrial-fibrillation
#3
R He, X Du, S W Liu, L J Sun, Y Li, H Zeng, Y Y Li, C Sun, Y Zhang, C S Ma, W Gao
Objective: To investigate the current status of antiarrhythmic drugs (AADs) use in Chinese patients with atrial fibrillation(AF) and assess the safety of AADs in this patient cohort. Methods: From January 2011 to December 2013, a total of 4 008 AF patients treated with AADs was enrolled in this study and patients were followed up for 24 months. Detailed information of prescribed drug, the causes of drug discontinuation and side effects were recorded. Results: Amiodarone was prescribed to 64.3%(2 579 cases) and propafenone to 31...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27876282/to-use-or-not-to-use-amiodarone-before-heart-transplantation
#4
Entela B Lushaj, Ravi Dhingra, Shahzad Chindhy, Shahab Akhter, Takushi Kohmoto, Susan Ulschmid, Satoru Osaki, Abbasali Badami, Lucian Lozonschi
BACKGROUND: Amiodarone frequently is used in patients with heart failure. Concerns still exist about possible complications related to its lingering effect during and after heart transplantation. METHODS: We selected all consecutive patients who received a heart transplant at our institution between January 2004 and December 2015 (n = 220) and compared the peri- and postoperative outcomes of patients who were taking amiodarone for at least 120 days before heart transplant (n = 127) with patients who did not take amiodarone prior to heart transplant (n = 93)...
November 19, 2016: Surgery
https://www.readbyqxmd.com/read/27794017/predictors-of-atrial-fibrillation-in-hypertrophic-cardiomyopathy
#5
Oliver P Guttmann, Menelaos Pavlou, Constantinos O'Mahony, Lorenzo Monserrat, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, Pablo Garcia-Pavia, William J McKenna, Rumana Z Omar, Perry M Elliott
OBJECTIVES: Atrial fibrillation (AF) is associated with increased morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM). The primary aim of this study (HCM Risk-AF) was to determine the predictors of AF in a large multicentre cohort of patients with HCM. Exploratory analyses were performed to investigate the association between AF and survival and the efficacy of antiarrhythmic therapy in maintaining sinus rhythm (SR). METHODS: A retrospective, longitudinal cohort of patients recruited between 1986 and 2008 in seven centres was used to develop multivariable Cox regression models fitted with preselected predictors...
October 28, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27779351/left-atrial-size-and-left-ventricular-end-systolic-dimension-predict-the-progression-of-paroxysmal-atrial-fibrillation-after-catheter-ablation
#6
Ying-Chieh Liao, Jo-Nan Liao, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Ta-Chuan Tuan, Abigail Louise D Te, Rohit Walia, Shinya Yamada, Chung-Hsing Lin, Chin-Yu Lin, Yao-Ting Chang, Suresh Allamsetty, Y U Wen-Chung, Jing-Long Huang, Tsu-Juey Wu, Shih-Ann Chen
INTRODUCTION: Although rare, some paroxysmal atrial fibrillations (AF) still progress despite radiofrequency (RF) ablation. In the study, we evaluated the long-term efficacy of RF ablation and the predictors of AF progression. METHODS: A total of 589 paroxysmal AF patients (404 men and 185 women; aged 54 ± 12 years) who received three-dimensional mapping and ablation were enrolled. Their clinical parameters and electrophysiological characteristics were collected...
October 25, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27773406/a-randomized-placebo-controlled-trial-with-amiodarone-for-persistent-atrial-fibrillation-in-rheumatic-mitral-stenosis-after-successful-balloon-mitral-valvuloplasty
#7
Vinoth Kumar Vilvanathan, Budunur C Srinivas Prabhavathi Bhat, Manjunath Cholenahally Nanjappa, Bharathi Pandian, Vithal Bagi, Sridhar Kasturi, Shiva Kumar Bandimida
OBJECTIVE: Atrial fibrillation is the most common sustained arrhythmia in patients with rheumatic heart disease (RHD). This study was conducted to determine the maintenance of sinus rhythm with amiodarone therapy following DC cardioversion (DCCV), early after successful balloon mitral valvuloplasty (BMV). METHODS: Patients were randomized to amiodarone group and placebo group and their baseline characteristics were recorded. DCCV was done 48h after BMV. After cardioversion, oral amiodarone was started initially 200mg three times a day for 2 weeks, then 200mg twice daily for two weeks followed by 200mg once daily for 12 months...
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27758968/the-novel-use-of-ranolazine-as-an-antiarrhythmic-agent-in-atrial-fibrillation
#8
C Michael White, Elaine Nguyen
OBJECTIVE: To review the limitations of current antiarrhythmic drugs in atrial fibrillation (AF) and discuss the rationale and clinical trials supporting the use of ranolazine in AF. DATA SOURCES: MEDLINE was searched from 1980 to September 2016 using the terms ranolazine, atrial fibrillation, coronary artery bypass grafting, and valve surgery STUDY SELECTION AND DATA EXTRACTION: English-language studies and reviews assessing antiarrhythmic drugs, including ranolazine, were incorporated...
October 6, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27746384/the-role-of-ranolazine-in-the-prevention-and-treatment-of-atrial-fibrillation-a-meta-analysis-of-randomized-clinical-trials
#9
Mengqi Gong, Zhiwei Zhang, Nikolaos Fragakis, Panagiotis Korantzopoulos, Konstantinos P Letsas, Guangping Li, Gan-Xin Yan, Tong Liu
BACKGROUND: Randomized controlled trials (RCTs) regarding use of ranolazine (RN) for the prevention and cardioversion of atrial fibrillation (AF) have yielded conflicting results. OBJECTIVE: we conducted a meta-analysis of RCTs to examine the potential role of RN in the prevention and cardioversion of AF. METHODS: PubMed and EMBASE were searched until June 2016. Of 484 initially identified studies, eight RCTs were finally analyzed. RESULTS: The analysis of RCTs showed that RN significantly reduced the incidence of AF compared to the control group in various clinical settings as following cardiac surgery, in acute coronary syndromes, and post electrical cardioversion of AF (RR = 0...
October 13, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#10
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27729264/prophylaxis-against-atrial-fibrillation-after-general-thoracic-surgery-trial-sequential-analysis-and-network-meta-analysis
#11
Bing-Cheng Zhao, Tong-Yi Huang, Qi-Wen Deng, Wei-Feng Liu, Jian Liu, Wen-Tao Deng, Ke-Xuan Liu, Cai Li
BACKGROUND: Postoperative atrial fibrillation/flutter (POAF) is associated with significant morbidity and mortality after general thoracic surgery, but the need and the best agent for prophylaxis remains obscure. METHODS: A systematic literature search was performed to identify randomized controlled trials that compared regimens for POAF prophylaxis after general thoracic surgery. Random-effects meta-analyses with trial sequential analyses were performed to compare the effects of medical prophylaxis versus placebo/usual care...
October 8, 2016: Chest
https://www.readbyqxmd.com/read/27722784/antiarrhythmic-effect-of-the-ca-2-activated-k-sk-channel-inhibitor-ica-combined-with-either-amiodarone-or-dofetilide-in-an-isolated-heart-model-of-atrial-fibrillation
#12
Jeppe Egedal Kirchhoff, Jonas Goldin Diness, Lea Abildgaard, Majid Sheykhzade, Morten Grunnet, Thomas Jespersen
Dose is an important parameter in terms of both efficacy and adverse effects in pharmacological treatment of atrial fibrillation (AF). Both of the class III antiarrhythmics dofetilide and amiodarone have documented anti-AF effects. While dofetilide has dose-related ventricular side effects, amiodarone primarily has adverse non-cardiac effects. Pharmacological inhibition of small conductance Ca(2+)-activated K(+) (SK) channels has recently been reported to be antiarrhythmic in a number of animal AF models. In a Langendorff model of acutely induced AF on guinea pig hearts, it was investigated whether a combination of the SK channel blocker N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA) together with either dofetilide or amiodarone provided a synergistic effect...
October 8, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27619976/st-segment-elevation-following-cardioversion-of-atrial-fibrillation-in-the-emergency-department-unmasked-myocardial-infarction-due-to-left-main-coronary-artery-plaque-rupture-or-unspecific-finding
#13
Dirk Prochnau, Ralf Surber, Matthias Hoyme, Sylvia Otto, Anna Selle, Tudor C Poerner
Atrial fibrillation (AF) is a frequent reason for emergency department visits. According to current guidelines either rate- or rhythm-control are acceptable therapeutic options in such situations. In this report, we present the complicated clinical course of a patient with AF and a rapid ventricular response. Because of paroxysmal AF, the patient was on chronic oral anticoagulation therapy with warfarin. Pharmacological treatment was ineffective to control ventricular rate, and immediate synchronized electrical cardioversion was performed...
September 13, 2016: CJEM
https://www.readbyqxmd.com/read/27617090/antiarrhythmic-drug-therapy-to-avoid-implantable-cardioverter-defibrillator-shocks
#14
Jaber Abboud, Joachim R Ehrlich
Implantable cardioverter defibrillators (ICDs) are effective in the prevention of arrhythmic sudden cardiac death. Many patients receiving an ICD are affected by heart failure and are at risk of ventricular arrhythmias, which may lead to appropriate shocks. On the other hand, in this population the incidence of atrial fibrillation, giving rise to inappropriate ICD shocks, is high. Accordingly, ICD discharges occur frequently and many patients with an ICD will need concomitant antiarrhythmic drug therapy to avoid or reduce the frequency of shocks...
August 2016: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/27574388/early-amiodarone-induced-pulmonary-toxicity-after-endovascular-aneurysm-repair-a-case-report
#15
Uzung Yoon, Laura Marinelli, Sayed Ali, Seymour Huberfeld, Rafael Barrera, John B Chang
Amiodarone is an antiarrhythmic drug that has been commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodine-containing compound that tends to accumulate in several organs, including the lungs. Especially, its main metabolically active metabolite desethylamiodarone can adversely affect many organs. A very well-known severe complication of amiodarone therapy is the amiodarone-induced pulmonary toxicity. This article presents the case study of an 82-year-old male patient with acute amiodarone-induced pulmonary toxicity...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27570120/management-of-new-onset-postoperative-atrial-fibrillation-utilizing-insertable-cardiac-monitor-technology-to-observe-recurrence-of-af-monitor-af
#16
Mikhael F El-Chami, Faisal M Merchant, Paige Smith, Mathew Levy, Angela Gill Nelms, John Merlino, John Puskas, Angel R Leon
BACKGROUND: New-onset postoperative atrial fibrillation (POAF) occurs in up to 30% of patients undergoing coronary artery bypass grafting (CABG). POAF is associated with short- and long-term mortality. METHODS: To identify the true incidence and time course of recurrent atrial fibrillation (AF) in patients with POAF, we prospectively assigned 23 patients with POAF to receive an implantable loop recorder (ILR; Medtronic Inc., Minneapolis, MN, USA) for the detection of recurrent AF...
October 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27568019/atrial-fibrillation-after-electrical-cardioversion-in-elderly-patients-a-role-for-arterial-stiffness-results-from-a-preliminary-study
#17
Stefano Fumagalli, Ilaria Giannini, Simone Pupo, Francesca Agostini, Serena Boni, Anna T Roberts, Debbie Gabbai, Claudia Di Serio, Luciano Gabbani, Francesca Tarantini, Niccolò Marchionni
BACKGROUND AND AIMS: Atrial fibrillation (AF) is the most frequent arrhythmia of the elderly, and electrical cardioversion (ECV) is a common procedure, although incidence of recurrences remains high. We evaluated the possible association between arterial stiffness (AS) and the persistence or recurrence of AF in elderly patients after ECV. METHODS: We enrolled all subjects undergoing ECV over a 9-month period. AS was evaluated with the cardio-ankle vascular index (CAVI)...
December 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27557313/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#18
LETTER
Sergiu P Darabant, Irwin Hoffman
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557312/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#19
LETTER
Alexander Sorisky
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557311/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#20
LETTER
Jesus A Barea-Mendoza, Renata García-Gigorro, Emilio Renes-Carreño
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
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