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https://www.readbyqxmd.com/read/28927254/integrated-analysis-of-microrna-and-mrna-expression-in-peripheral-blood-leukocytes-of-warmblood-horses-before-and-after-exercise
#1
Hang-Ah Kim, Myung-Chul Kim, Na-Yon Kim, Doug-Young Ryu, Hong-Seok Lee, Yongbaek Kim
Exercise capacity is a valuable trait in horses, and it has been used as one of their selection criteria. Although exercise affects molecular homeostasis and adaptation in horses, the mechanisms underlying these effects are not fully understood. This study was carried out to identify changes in the blood profiles of microRNAs (miRNAs) and mRNAs induced by exercise in horse leukocytes. Total RNAs isolated from the peripheral blood leukocytes of four Warmblood horses before and after exercise were subjected to next-generation sequencing (NGS) and microarray analyses to determine the miRNA and mRNA expression profiles, respectively...
September 20, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28926961/effects-of-metal-ions-temperature-and-a-denaturant-on-the-oxidative-folding-pathways-of-bovine-%C3%AE-lactalbumin
#2
Reina Shinozaki, Michio Iwaoka
Bovine α-lactalbumin (αLA) has four disulfide (SS) bonds in the native form (N). On the oxidative folding pathways of this protein, two specific SS folding intermediates, i.e., (61-77, 73-91) and des[6-120], which have two and three native SS bonds, respectively, accumulate predominantly in the presence of Ca(2+). In this study, we reinvestigated the pathways using a water-soluble cyclic selenoxide reagent, trans-3,4-dihydroxyselenolane oxide (DHS(ox)), as a strong and quantitative oxidant to oxidize the fully reduced form (R)...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926927/grim-19-represses-the-proliferation-and-invasion-of-cutaneous-squamous-cell-carcinoma-cells-associated-with-downregulation-of-stat3-signaling
#3
Na Wu, Haiying Hui, Li Cui, Fan Yang
The gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) has been identified as a tumor suppressor in many human cancers. However, little is known about the role of GRIM-19 in cutaneous squamous cell carcinoma (CSCC). Here, we aimed to investigate the potential function of GRIM-19 in CSCC and explore the underlying molecular mechanisms. We found that GRIM-19 protein and transcript levels were significantly decreased in CSCC cell lines. Overexpression of GRIM-19 suppressed the proliferation and invasion of CSCC cells, whereas knockdown of GRIM-19 promoted the proliferation and invasion of CSCC cells...
September 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28926823/preparation-characterization-and-application-of-urease-nanoparticles-for-construction-of-an-improved-potentiometric-urea-biosensor
#4
Seema Jakhar, C S Pundir
The nanoparticles (NPs) aggregates of commercial urease from jack beans (Canavalia ensiformis) were prepared by desolvation and glutaraldehyde crosslinking and functionalized by cysteamine dihydrochloride. These enzyme nanoparticles (ENPs) were characterized by transmission electron microscopy (TEM), UV and Fourier transform infrared (FTIR) spectroscopy. The TEM images of urease NPs showed their size in the range, 18-100nm with an average of 51.2nm. The ENPs were more active and stable with a longer shelf life than native enzyme molecules...
September 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28926790/migration-and-distribution-of-sodium-ions-and-organic-matters-during-electro-dewatering-of-waste-activated-sludge-at-different-dosages-of-sodium-sulfate
#5
Jun Xiao, Xu Wu, Wenbo Yu, Sha Liang, Jiangwei Yu, Yueyuan Gu, Huali Deng, Jiukun Hu, Keke Xiao, Jiakuan Yang
In this study, the influence of Na2SO4 on electro-dewatering (EDW) of waste activated sludge (WAS) was investigated. The highest water removal efficiency of 42.5% was achieved at the optimum Na2SO4 dosage of 12.5 g kg(-1) DS during EDW process at a constant voltage of 20 V. The migration and distribution of water, organic matters and Na(+) at different Na2SO4 dosages were investigated through layered experiments. The results indicated the entire EDW process followed the S curve model, and it can be divided into three stages: (1) initial desalination stage: at the initial few min of EDW process, the rate of electroosmosis was extremely slow while electromigration of ions like Na(+) was intense, and the electromigration was more obvious with increased Na2SO4 dosage; (2) dewatering stage: the dewatering efficiency increased dramatically via electroosmosis; (3) the dewaterability limit stage: the maximum value of dewatering efficiency has been achieved, while the water removal efficiency and dry solids content remained constant...
September 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926785/a-new-v-doped-bi2-o-s-3-oxysulfide-catalyst-for-highly-efficient-catalytic-reduction-of-2-nitroaniline-and-organic-dyes
#6
Angaw Kelemework Abay, Dong-Hau Kuo, Xiaoyun Chen, Albert Daniel Saragih
A new type of convenient, and environmentally friendly, Vanadium (V)-doped Bi2(O,S)3 oxysulfide catalyst with different V contents was successfully synthesized via a simple and facile method. The obtained V-doped Bi2(O,S)3 solid solution catalysts were fully characterized by conventional methods. The catalytic performance of the samples was tested by using the reduction of 2-nitroaniline (2-NA) in aqueous solution. The reduction/decolorization of methylene blue (MB) and rhodamine B (RhB) was also chosen to evaluate the universality of catalysts...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926723/porous-wo3-graphene-polyester-textile-electrode-materials-with-enhanced-electrochemical-performance-for-flexible-solid-state-supercapacitors
#7
Li-Na Jin, Ping Liu, Chun Jin, Jia-Nan Zhang, Shao-Wei Bian
In this work, a flexible and porous WO3/grapheme/polyester (WO3/G/PT) textile electrode was successfully prepared by in situ growing WO3 on the fiber surface inside G/PT composite fabrics. The unique electrode structure facilitates to enhance the energy storage performance because the 3D conductive network constructed by the G/PT increase the electron transportation rate, nanotructured WO3 exposed enhanced electrochemically active surface area and the hierarchically porous structure improved the electrolyte ion diffusion rate...
September 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28926624/molecular-characterization-expression-analysis-and-heterologous-expression-of-two-translationally-controlled-tumor-protein-genes-from-cucumis-sativus
#8
Xiang Nan Meng, Qiu Min Chen, Hai Yan Fan, Tie Feng Song, Na Cui, Ju Yong Zhao, Shu Min Jia, Ke Xin Meng
The translationally controlled tumor protein (TCTP) is a family of abundant and ubiquitous proteins involved in several important primary functions. Cucumbers harbor two TCTP genes, CsTCTP1 and CsTCTP2; however, their functional roles remain unclear. In this study, we isolated CsTCTP1 and CsTCTP2 (XP-004134215 and XP-004135602, respectively) promoters, full-length cDNA and genomic sequences from Cucumis sativus. Bioinformatics analysis, containing cis-acting elements, structural domains, phylogenetic tree and conserved motifs, suggested the conservation and divergence of CsTCTP1 and CsTCTP2, thus providing knowledge regarding their functions...
2017: PloS One
https://www.readbyqxmd.com/read/28926298/association-between-coffee-consumption-and-circulating-levels-of-adiponectin-and-leptin
#9
Chang Beom Lee, Sung Hoon Yu, Na Yeon Kim, Seon Mee Kim, Sung Rae Kim, Seung Joon Oh, Sun Ha Jee, Jung Eun Lee
Coffee has been proposed to have benefits for chronic diseases; however, the relevant mechanism remains to be elucidated. We conducted a cross-sectional study and evaluated the levels of adiponectin and leptin in relation to coffee consumption. We included a total of 4406 individuals (men = 2587 and women = 1819) for adiponectin analysis and 2922 individuals (men = 1731 and women = 1191) for leptin analysis. Participants answered number of cups of coffee per week and types of coffee they consumed and their serum levels of adiponectin and leptin were measured using an enzyme-linked immunosorbent assay...
September 19, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28926257/how-to-control-the-discharge-products-in-na-o2-cells-direct-evidence-toward-the-role-of-functional-groups-at-the-air-electrode-surface
#10
Hossein Yadegari, Christopher J Franko, Mohammad Norouzi Banis, Qian Sun, Ruying Li, Gillian R Goward, Xueliang Sun
Sodium-oxygen batteries have received a significant amount of research attention as a low-overpotential alternative to lithium-oxygen. However, the critical factors governing the composition and morphology of the discharge products in Na-O2 cells are not thoroughly understood. Here we show that oxygen containing functional groups at the air electrode surface have a substantial role on the electrochemical reaction mechanisms in Na-O2 cells. Our results show that presence of functional groups at the air electrode surface conducts the growth mechanism of discharge products toward a surface-mediated mechanism, forming a conformal film of products at the electrode surface...
September 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28926231/resonance-emission-enhancement-ree-for-narrow-band-red-emitting-a2gef6-mn-4-a-na-k-rb-cs-phosphors-synthesized-via-a-precipitation-cation-exchange-route
#11
Hongzhou Lian, Qingming Huang, Yeqing Chen, Kai Li, Sisi Liang, Mengmeng Shang, Manman Liu, Jun Lin
Narrow band red-emitting A2GeF6:Mn(4+) (A = Na, K, Rb, Cs) phosphors were prepared through a two-step precipitation-cation exchange route using a K2MnF6 precursor as the Mn(4+) source. The phase purity, morphology, and constituent were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectric spectroscopy (XPS), and electron paramagnetic resonance (EPR) examination. Optical properties were investigated by photoluminescence spectra (PL and PLE) and high-resolution PL. A temperature-dependent PL examination was performed to investigate the electron-phonon coupling emission mechanism of Mn(4+) in these alkali fluorogermanates...
September 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28926137/metabolic-profile-of-rhizoma-coptidis-in-human-plasma-determined-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry
#12
Qing-Shan Zhang, Gao-Wa Wang, Zhi-Qiang Han, Xiang-Mei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
RATIONALE: Rhizoma coptidis extract and its alkaloids show various pharmacological activities, but its metabolic profile in human plasma has not been thoroughly investigated. In the present research, the metabolism of Rhizoma coptidis at a clinical dose (5 g/60 kg/day) was systematically analyzed to determine its biotransformation processes in human plasma. METHODS: In this research, the metabolites of Rhizoma coptidis in human plasma after oral administration of Rhizoma coptidis extract at a clinical dose were investigated using ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometry...
September 19, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28926106/oroxyloside-inhibits-angiogenesis-through-suppressing-internalization-of-vegfr2-flk-1-in-endothelial-cells
#13
Kai Zhao, Xiaorui Li, Binyan Lin, Dawei Yang, Yuxin Zhou, Zhiyu Li, Qinglong Guo, Na Lu
Increasing flavonoids have been reported to possess anti-angiogenic effects. Inhibition of angiogenesis plays a critical role in the treatment of cancer, especially in advanced metastatic cancer. In this study, we assessed the effect of Oroxylin A-7-glucuronide (Oroxyloside), a main metabolite of Oroxylin A, on angiogenesis in human endothelial cell-like EA.hy926 cells. Oroxyloside suppressed the migration and tube formation of EA.hy926 cells. Meanwhile, microvessels sprouting from aortic rings and new blood vessels on the chicken chorioallantoic membrane (CAM) were also inhibited...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28926049/one-pot-synthesis-of-multicomponent-mo-co-metal-sulfide-carbon-nanoboxes-as-anode-materials-for-improving-na-ion-storage
#14
Juan Xiang, Taeseup Song
Multicomponent MoS2/Co9S8/C hollow nanocubes were developed by the one-pot solvothermal method and a subsequent calcination process. Benefitting from the merits of hollow structures, the highly-conductive carbon matrix and the buffering effect provided by uniformly-mixed MoS2 and Co9S8, the MoS2/Co9S8/C anode shows high capacity and rate capability as the anode of sodium-ion batteries.
September 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28925723/expression-patterns-of-members-of-the-isocitrate-dehydrogenase-gene-family-in-murine-inner-ear
#15
Y-R Kim, K-H Kim, S Lee, S-K Oh, J-W Park, K-Y Lee, J-I Baek, U-K Kim
Age-related hearing loss (ARHL) is characterized by an age-dependent decline of auditory function characterized by with loss of sensory hair cells, spiral ganglion neurons, and stria vascularis (SV) cells in the cochlea of the inner ear. Aging and age-related diseases result from accumulated oxidative damage caused by reactive oxygen species (ROS) generated by mitochondria. The isocitrate dehydrogenase (IDH) family includes three enzymes in human cells: IDH1, IDH2, and IDH3. Although all three enzymes catalyze the same enzymatic reaction, that is, oxidative decarboxylation of isocitrate to produce α-ketoglutarate, each IDH enzyme has unique features...
September 19, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28925686/a-naphthalimide-based-fluorophore-for-soft-anionic-interface-monitoring
#16
Li Wang, Gang Wang, Congdi Shang, Rui Kang, Yu Fang
A naphthalimide-based low-molecular mass fluorophore (NA) was designed and synthesized by introducing an azetidine unit onto the aromatic ring of the compound as an electron-donating structure, and a hydrophilic (2-(2-aminoethylamino)ethanol) moiety into the 'N-imide site' of the core structure. UV-vis absorption and fluorescence measurements revealed that the fluorophore is soluble in water, and shows a fluorescent quantum yield of ~20% and lifetime of ~3.7 ns in the solvent within a wide pH range. Moreover, the fluorescence emission and anisotropy of the fluorophore as produced are both dependent upon the viscosity and polarity of the medium...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925684/carbon-nanotube-based-ion-selective-sensors-for-wearable-applications
#17
Soumyendu Roy, Moshe David-Pur, Yael Hanein
Wearable electronics offer new opportunities in a wide range of applications, especially sweat analysis using skin sensors. A fundamental challenge in these applications is the formation of sensitive and stable electrodes. In this article we report the development of a wearable sensor based on carbon nanotube (CNT) electrode arrays for sweat sensing. Solid-state ion selective electrodes (ISEs), sensitive to Na+ ions, were prepared by drop coating plasticized poly-vinyl chloride (PVC) doped with ionophore and ion exchanger on CNT electrodes...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925516/co3o4-nanowire-arrays-toward-superior-water-oxidation-electrocatalysis-in-alkaline-media-by-surface-amorphization
#18
Xuping Sun
In this communication, we report our recent finding that the generation of amorphous Co-Bi layer on Co3O4 nanowire arrays supported on Ti mesh (Co3O4@Co-Bi NA/TM) leads to significantly boosted OER activity. The as-prepared Co3O4@Co-Bi NA/TM demands overpotential of 304 mV to drive a ge-ometrical current density of 20 mA cm-2 in 1.0 M KOH, which is 109 mV less than that for Co3O4 NA/TM, with its catalytic activity being preserved for at least 20 h. It suggests that the existence of amorphous Co-Bi layer promotes more CoOx(OH)y generation on Co3O4 surface...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28925296/vaccine-approaches-conferring-cross-protection-against-influenza-viruses
#19
Sai V Vemula, Ekramy E Sayedahmed, Suryaprakash Sambhara, Suresh K Mittal
Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of the currently available influenza vaccines are strong inducers of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants...
September 19, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28925252/the-binary-and-tertiary-complex-based-on-short-chain-glucan-and-proanthocyanidins-for-oral-insulin-delivery
#20
Na Ji, Yan Hong, Zhengbiao Gu, Li Cheng, Zhaofeng Li, Caiming Li
The present study was performed to investigate binary and tertiary nanocomposites between short-chain glucan (SCG) and proanthocyanidins (PAC) for the oral delivery of insulin. There was a large decrease in fluorescence intensity of insulin in the presence of SGC or the combination of SGC with PAC. Fourier transform infrared spectroscopy revealed that the binary and tertiary nanocomposites were synthesized due to the hydrogen bonding and hydrophobic interactions. The insulin entrapped in the nanocomposites was in an amorphous state confirmed by X-ray diffraction...
September 19, 2017: Journal of Agricultural and Food Chemistry
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