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https://www.readbyqxmd.com/read/29786073/integrin-%C3%AE-6%C3%AE-4-src-akt-signaling-induces-cellular-senescence-by-counteracting-apoptosis-in-irradiated-tumor-cells-and-tissues
#1
Seung Hee Jung, Minyoung Lee, Hyun A Park, Hyung Chul Lee, Donghee Kang, Hyun Jung Hwang, Chanho Park, Dong-Min Yu, Yu Ri Jung, Mi-Na Hong, Yong-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Lee
Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism remains unknown. Here we show that the activation of integrin β4 is essential for IR-induced cellular senescence. IR treatment results in the phosphorylation of integrin β4 at tyrosine residue 1510, leading to activation of the integrin α6β4-Src-AKT signaling pathway...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29786068/mitochondrial-pip3-binding-protein-fundc2-supports-platelet-survival-via-akt-signaling-pathway
#2
Qi Ma, Chongzhuo Zhu, Weilin Zhang, Na Ta, Rong Zhang, Lei Liu, Du Feng, Heping Cheng, Junling Liu, Quan Chen
Platelets undergo apoptosis in response to a variety of stimuli in the circulation. Mitochondria in platelets are essential for their apoptosis. Specifically, pro-survival protein BCL-xL on mitochondria is the key regulator of platelet lifespan. Here we identify an outer mitochondrial membrane protein FUNDC2 for platelet survival. FUNDC2 knockout mice carrying excessively apoptotic platelets exhibit thrombocytopenia in response to hypoxia. Mechanistically, FUNDC2 binds the lipid PIP3 via its unique, highly conserved N-terminal motif...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29786044/prognostic-value-of-model-for-end-stage-liver-disease-incorporating-with-serum-sodium-score-for-development-of-acute-kidney-injury-after-liver-transplantation
#3
Yuan Cheng, Guo-Qing Wei, Qiu-Cheng Cai, Yi Jiang, Ai-Ping Wu
Background: Contribution of model for end-stage liver disease incorporating with serum sodium (MELD-Na) score in predicting acute kidney injury (AKI) after orthotopic liver transplantation (OLT) is yet to be identified. This study assessed the prognostic value of MELD-Na score for the development of AKI following OLT. Methods: Preoperative and surgery-related variables of 321 adult end-stage liver disease patients who underwent OLT in Fuzhou General Hospital were collected...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785969/pillared-graphite-anodes-for-reversible-sodiation
#4
Hanyang Zhang, Zhifei Li, Wei Xu, Yicong Chen, Xiulei Ji, Michael M Lerner
There has been a major effort recently to develop new rechargeable sodium-ion electrodes. In lithium ion batteries, LiC6 forms from graphite and de-solvated Li cations during the first charge. With sodium ions, graphite only shows a significant capacity when Na+ intercalates as a solvated complex, resulting in ternary graphite intercalation compounds (GICs). Although this chemistry has been shown to be highly reversible and to support high rates in small test cells, these GICs can require >250% volume expansion and contraction during cycling...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29785923/cholera-outbreak-due-to-raw-seafood-consumption-in-south-korea-2016
#5
Jeong Hyun Kim, Jin Lee, Sahyun Hong, Sangwon Lee, Hae-Young Na, Young-Il Jeong, Eun Jin Choi, Junyoung Kim, Hyo Sun Kawk, Enhi Cho
Three cases of cholera occurred in South Korea during a period of three weeks in August 2016. All the cases were associated with the consumption of raw seafood in southern coastal area of South Korea. Epidemiologic investigations were performed to track the spread of cholera, including persons in contact with the cholera patients, seafood, and seawater from the fish tank and marine environments. A microbiological investigation demonstrated that cholera isolated from the three patients and a seawater sample at the Korea Strait showed identical serotype (O1 Ogawa), biotype (El tor), and toxin ( ctx -positive)...
May 21, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29785877/hepatitis-b-virus-lymphotropism-emerging-details-and-challenges
#6
Shivali S Joshi, Carla S Coffin
The hepatitis B virus (HBV) is predominantly a hepatotropic virus but also infects cells of the lymphatic system. HBV genomes (DNA, messenger (m)RNA, covalently closed circular (ccc) DNA) and proteins have been found in extrahepatic sites such as peripheral blood mononuclear cells (PBMC), lymph nodes, spleen, bone marrow and cerebrospinal fluid. HBV entry into hepatocytes occurs by binding of the HBV preS1 surface protein to its specific receptor, the bile acid transporter, sodium taurocholate co-transporting polypeptide (NTCP)...
May 22, 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29785595/a-preliminary-investigation-on-water-quality-of-coalbed-natural-gas-produced-water-for-beneficial-uses-a-case-study-in-the-southern-qinshui-basin-north-china
#7
Zheng Zhang, Yong Qin
Coalbed natural gas (CBNG) is an important unconventional natural gas resource with large reserves in China and receives much attention these years. The CBNG production is accomplished by extracting large volumes of produced water from the aquifer. The CBNG-produced water is commonly managed by discharging into nearby disposal ponds in the Southern Qinshui Basin (SQB), which provides an opportunity for water source for nearby irrigation, livestock, wildlife, and human drinking water. However, utilization of this nontraditional water source in the SQB is hindered by limited knowledge of water quality, practically oxidation/reduction potential (OPR), electrical conductivity (EC), sodium adsorption ration (SAR), and trace element chemistry data...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785281/impact-of-the-applied-simulated-and-integrated-learning-approach-on-nursing-assistants-knowledge-and-confidence-caring-for-frail-seniors-in-nursing-homes
#8
Veronique M Boscart, George Heckman, Meaghan Davey, Michelle Heyer, John P Hirdes
Background: Increasing importance is being placed on optimizing the role of Nursing Aides (NAs) in improving quality of care for nursing home (NH) residents. One approach to do so is to have NAs participate in assessments embedded within the Minimum Data Set (MDS). This pilot study aimed to design and evaluate the Applied Simulated and Integrated Learning Approach (ASILA) program, a novel innovative training program for NAs employed in NHs to enhance their ability to assess residents within an inter-professional framework...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29785032/solvents-can-control-solute-molecular-identity
#9
Devon R Widmer, Benjamin J Schwartz
For solution-phase chemical reactions, the solvent is often considered simply as a medium to allow the reactants to encounter each other by diffusion. Although examples of direct solvent effects on molecular solutes exist, such as the compression of solute bonding electrons due to Pauli repulsion interactions, the solvent is not usually considered a part of the chemical species of interest. We show, using quantum simulations of Na2 , that when there are local specific interactions between a solute and solvent that are energetically on the same order as a hydrogen bond, the solvent controls not only the bond dynamics but also the chemical identity of the solute...
May 21, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29785024/targeting-skeletal-endothelium-to-ameliorate-bone-loss
#10
Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G Poulos, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M Butler, Jae-Hyuck Shim, Laurie H Glimcher, Matthew B Greenblatt
Recent studies have identified a specialized subset of CD31hi endomucinhi (CD31hi EMCNhi ) vascular endothelium that positively regulates bone formation. However, it remains unclear how CD31hi EMCNhi endothelium levels are coupled to anabolic bone formation. Mice with an osteoblast-specific deletion of Shn3, which have markedly elevated bone formation, demonstrated an increase in CD31hi EMCNhi endothelium. Transcriptomic analysis identified SLIT3 as an osteoblast-derived, SHN3-regulated proangiogenic factor...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29785022/novel-peptide-gx1-inhibits-angiogenesis-by-specifically-binding-to-transglutaminase-2-in-the-tumorous-endothelial-cells-of-gastric-cancer
#11
Zhijie Lei, Na Chai, Miaomiao Tian, Ying Zhang, Guodong Wang, Jian Liu, Zuhong Tian, Xiaofang Yi, Di Chen, Xiaowei Li, Pengfei Yu, Hao Hu, Bing Xu, Chao Jian, Zhenyuan Bian, Hao Guo, Jinpeng Wang, Shiming Peng, Yongzhan Nie, Niu Huang, Sijun Hu, Kaichun Wu
The clinical application of GX1, an optimal gastric cancer (GC) targeting peptide, is greatly limited because its receptor in the GC vasculature is unknown. In this study, we screened the candidate receptor of GX1, transglutaminase-2(TGM2), by co-immunoprecipitation (co-IP) combined with mass spectrometry. We found that TGM2 was up-regulated in GC vascular endothelial cells and that GX1 receptor expression was suppressed correspondingly after TGM2 downregulation. A highly consistent co-localization of GX1 receptor and TGM2 was detected at both the cellular and tissue levels...
May 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29784887/identification-of-the-thioredoxin-partner-of-vkor-in-mycobacterial-disulfide-bond-formation
#12
Na Ke, Cristina Landeta, Xiaoyun Wang, Dana Boyd, Markus Eser, Jon Beckwith
Disulfide bonds influence stability and activity of many proteins. In Escherichia coli the DsbA and DsbB enzymes promote disulfide bond formation. Other bacteria, including the Actinobacteria, use instead of DsbB the enzyme VKOR (Vitamin K Epoxide Reductase), which is found either fused to or encoded in the same operon as a dsbA -like protein. Mycobacterium tuberculosis and other gram-positive Actinobacteria secrete to the cell envelope many proteins with even numbers of cysteines. These organisms have predicted oxidoreductases and VKOR orthologs...
May 21, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29784674/clinically-relevant-cytotoxic-immune-cell-signatures-and-clonal-expansion-of-t-cell-receptors-in-high-risk-mycn-not-amplified-human-neuroblastoma
#13
Jun S Wei, Igor B Kuznetsov, Shile Zhang, Young K Song, Shahab Asgharzadeh, Sivasish Sindiri, Xinyu Wen, Rajesh Patidar, Sushma Nagaraj, Ashley Walton, Jaime M Guidry Auvil, Daniela S Gerhard, Aysen Yuksel, Daniel R Catchpoole, Stephen M Hewitt, Paul M Sondel, Robert C Seeger, John M Maris, Javed Khan
PURPOSE: High-risk neuroblastoma is an aggressive disease. DNA sequencing studies have revealed a paucity of actionable genomic alterations and a low mutation burden, posing challenges to develop effective novel therapies. We used RNA sequencing (RNA-seq) to investigate the biology of this disease including a focus on tumor-infiltrating lymphocytes (TILs). EXPERIMENTAL DESIGN: We performed deep RNA-seq on pre-treatment diagnostic tumors from 129 high-risk and 21 low- or intermediate-risk patients with neuroblastomas...
May 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29784419/development-of-a-method-for-the-elemental-analysis-of-milk-powders-using-laser-ablation-inductively-coupled-plasma-mass-spectrometry-la-icp-ms-and-its-potential-use-in-geographic-sourcing
#14
Tricia Hoffman, Radojko Jaćimović, Lian Jie Bay, Julieta Griboff, Marta Jagodic, Magdalena Monferrán, Nives Ogrinc, Ivan Podkolzin, Daniel Wunderlin, Jose Almirall
Milk has been reported as one of the most adulterated foodstuffs in the developed and developing world. One way to detect adulteration is to determine whether the country of origin on the label could be the actual country of origin. Such profiling may be accomplished through the use of elemental analysis techniques, however this is a preliminary study and this goal is not yet met. In this study, a laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) method was developed for the analysis of solid milk powder and compared to k0 -instrumental neutron activation analysis (k0 -INAA) for a reference milk material (IAEA-153) as well as several milk samples from different countries...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784359/facile-fabrication-of-ternary-tio-2-gold-nanoparticle-graphene-oxide-nanocomposites-for-recyclable-surface-enhanced-raman-scattering
#15
Lu-Lu Qu, Na Wang, Gen Zhu, T P Yadav, Xinting Shuai, Dandan Bao, Guohai Yang, Dawei Li, Haitao Li
A bi-functional ternary nanocomposite was developed by decorating TiO2 and gold nanoparticles on the reduced graphene oxide nanosheets (TiO2 -Au-rGO) for recyclable surface enhanced Raman scattering (SERS) detection. TiO2 -Au-rGO nanocomposites have been shown to demonstrate the superior SERS performances, which can be used for highly sensitive detection of rhodamine 6 G with a limit of detection of 1.2 × 10-10 M. Subsequently, the surface can be cleaned automatically by the photocatalytic degradation of the adsorbed analytes into inorganic small molecules under visible light irradiation...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784347/simultaneous-sampling-of-dissolved-orthophosphate-and-ammonium-in-freshwaters-using-diffusive-gradients-in-thin-films-with-a-mixed-binding-phase
#16
Zhongmin Feng, Ni Wang, Manli He, Lan Yang, Yun Wang, Ting Sun
A new diffusive gradients in thin films (DGT) technique with a micro-sized biochar-zeolite-zirconium oxide mixed binding phase is described for simultaneous sampling of dissolved orthophosphate and ammonium in freshwaters. The performance of mixed binding layer (MBL) DGT technique was characterized by evaluation of the following parameters: (1) the adsorption efficiency of phosphate and ammonium by the mixed binding phase, (2) the elution efficiency, (3) the time-series accumulation, and (4) the influences of pH, coexisting cations and DOC on DGT uptake...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784345/development-of-dried-serum-spot-sampling-techniques-for-the-assessment-of-trace-elements-in-serum-samples-by-la-icp-ms
#17
María Pilar Chantada-Vázquez, Jorge Moreda-Piñeiro, Alicia Cantarero-Roldán, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro
A novel approach for serum analysis by dried matrix spot (DMS) technique is proposed. The methodology consists of sampling filter paper discs (2.7 mm in diameter) containing the large amount of serum retained after a single spotting. Several oxidizers (sodium chlorate, sodium azide, acetic acid, formic acid, 1-butyl-3-methylimidazoliumm chloride/bromide) were tested (oxidizers premixed with the sample before spotting, and papers previously soaked in concentrated additive/oxidizer solutions). Direct multi-element determination (Al, Be, Ca, Cu, Fe, K, Li, Mg, Mn, Mo, Na, P, Rb, Se, V, and Zn) in dried serum spots at very low levels was therefore assessed by laser ablation (LA) coupled with inductively coupled plasma - mass spectrometry (ICP-MS)...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783993/cirsimaritin-inhibits-influenza-a-virus-replication-by-downregulating-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#18
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li
BACKGROUND: Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains. Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Thus, the aim of this study is to investigate the anti-influenza virus efficacy and antiviral mechanism of CST. METHODS: The inhibitory activity of CST against influenza viruses was assessed by using viral titers and performing Western blot, qRT-PCR, and immunofluorescence assays in Madin-Darby canine kidney (MDCK) cells and a human monocytic cell line (THP-1)...
May 21, 2018: Virology Journal
https://www.readbyqxmd.com/read/29783866/effect-of-the-flame-retardant-tris-1-3-dichloro-2-propyl-phosphate-tdcpp-on-na-k-atpase-and-cl-transport-in-hela-cells
#19
Simona Latronico, Maria Elena Giordano, Emanuela Urso, Maria Giulia Lionetto, Trifone Schettino
Tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is one of the most diffused phosphorus flame retardants in the environment and is highly persistent and abundant in residential dust samples. To date the cellular targets and mechanisms underlying its toxic effects are not completely understood. The aim of this work was to study the effects of TDCPP on ion transport mechanisms fundamental for the cellular ionic homeostasis, such as Na+ -K+ -ATPase and Cl- transport. HeLa cells were used as experimental model. TDCPP showed a dose-dependent effect on cell viability in cells exposed for 24h as assessed by MTT test (IC50 = 52...
May 21, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29783843/big-groundwater-datasets-reveal-possible-rare-contamination-amid-otherwise-improved-water-quality-for-some-analytes-in-a-region-of-marcellus-shale-development
#20
Tao Wen, Xianzeng Niu, Matthew Gonzales, Guanjie Zheng, Zhenhui Li, Susan Louise Brantley
Eleven thousand groundwater samples collected in the 2010s in an area of Marcellus shale-gas development are analyzed to assess spatial and temporal patterns of water quality. Using a new data mining technique, we confirm previous observations that methane concentrations in groundwater tend to be naturally elevated in valleys and near faults, but we also show that methane is also more concentrated near anticlines. Data mining also highlights waters with elevated methane that are not otherwise explained by geologic features...
May 22, 2018: Environmental Science & Technology
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