keyword
MENU ▼
Read by QxMD icon Read
search

vascular mimicry

keyword
https://www.readbyqxmd.com/read/29750896/migration-inducing-gene-7-independently-predicts-poor-prognosis-of-human-osteosarcoma-and-is-associated-with-vasculogenic-mimicry
#1
Ke Ren, Jian Zhang, Xiaojie Gu, Sujia Wu, Xin Shi, Yicheng Ni, Yong Chen, Jun Lu, Zengxin Gao, Chen Wang, Nan Yao
Vasculogenic mimicry (VM) is a special type of vascular channel formed by tumor cells without endothelial cell participation. Migration-inducing gene 7 (MIG-7) plays an important role in regulating VM. In this study, immunohistochemical staining was used to detect MIG-7 in tissue specimens from 141 primary osteosarcoma patients, and the relationship between MIG-7 and VM was examined. Survival analysis were performed to evaluate the prognoses. MIG-7 knockdown osteosarcoma cells were used for cell proliferation, apoptosis, migration, invasiveness and VM formation assays...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29749455/anti%C3%A2-metastatic-effects-of-aidi-on-human-esophageal-squamous-cell-carcinoma-by-inhibiting-epithelial%C3%A2-mesenchymal-transition-and-angiogenesis
#2
Qingtong Shi, Yali Diao, Feng Jin, Zhiyan Ding
Aidi injection, a proprietary Chinese medicine, has been widely used for the treatment of cancer. However, its effects and potential mechanism in esophageal squamous cell carcinoma (ESCC) have not yet been characterized. The aim of the present study was to identify the mechanism underlying the anti‑metastatic effects of treatment with Aidi. To test the effects and mechanism, EC9706 and KYSE70 cells were selected for in vitro experiments. In vivo, the anti‑metastatic effects of Aidi injection on a nude mouse peritoneal metastasis model were examined, and the mechanisms were assessed with immunohistochemical staining...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748585/humanizing-miniature-hearts-through-4-flow-cannulation-perfusion-decellularization-and-recellularization
#3
Duong T Nguyen, Matthew O'Hara, Cecilia Graneli, Ryan Hicks, Tasso Miliotis, Ann-Christin Nyström, Sara Hansson, Pia Davidsson, Li-Ming Gan, Maria Chiara Magnone, Magnus Althage, Sepideh Heydarkhan-Hagvall
Despite improvements in pre-clinical drug testing models, predictability of clinical outcomes continues to be inadequate and costly due to poor evidence of drug metabolism. Humanized miniature organs integrating decellularized rodent organs with tissue specific cells are translational models that can provide further physiological understanding and evidence. Here, we evaluated 4-Flow cannulated rat hearts as the fundamental humanized organ model for cardiovascular drug validation. Results show clearance of cellular components in all chambers in 4-Flow hearts with efficient perfusion into both coronary arteries and cardiac veins...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29707148/dual-antiplatelet-therapy-with-clopidogrel-and-aspirin-increases-mortality-in-4t1-metastatic-breast-cancer-bearing-mice-by-inducing-vascular-mimicry-in-primary-tumour
#4
Marta Smeda, Anna Kieronska, Bartosz Proniewski, Agnieszka Jasztal, Anna Selmi, Krystyna Wandzel, Agnieszka Zakrzewska, Tomasz Wojcik, Kamil Przyborowski, Katarzyna Derszniak, Marta Stojak, Dawid Kaczor, Elzbieta Buczek, Cezary Watala, Joanna Wietrzyk, Stefan Chlopicki
Platelet inhibition has been considered an effective strategy for combating cancer metastasis and compromising disease malignancy although recent clinical data provided evidence that long-term platelet inhibition might increase incidence of cancer deaths in initially cancer-free patients. In the present study we demonstrated that dual anti-platelet therapy based on aspirin and clopidogrel (ASA+Cl), a routine regiment in cardiovascular patients, when given to cancer-bearing mice injected orthotopically with 4T1 breast cancer cells, promoted progression of the disease and reduced mice survival in association with induction of vascular mimicry (VM) in primary tumour...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29703523/four-surgical-modifications-to-the-classic-elastase-perfusion-aneurysm-model-enable-haemodynamic-alterations-and-extended-elastase-perfusion
#5
Albert Busch, Ekaterina Chernogubova, Hong Jin, Felix Meurer, Hans-Henning Eckstein, Mia Kim, Lars Maegdefessel
OBJECTIVE/BACKGROUND: Abdominal aortic aneurysm (AAA) is an individual and socioeconomic burden in today's ageing society. Treatment relies on surgical exclusion of the dilated aorta by open or endovascular repair. For research purposes, animal models are necessary and the elastase induced aneurysm model closely mimics end stage human aneurysm disease. To improve the translational value of this model, four modifications to the classic elastase perfusion procedure (PPE) in relation to human aneurysm morphology were conducted...
April 24, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29693128/a-novel-monoclonal-antibody-targeting-a-novel-epitope-of-ve%C3%A2-cadherin-inhibits-vasculogenic-mimicry-of-lung-cancer-cells
#6
Jie Ding, Xi Jia, Bin Zuo, Jun He, Jianfeng Yang, Yang He
Vascular endothelial cadherin (VE‑cadherin) was first found in vascular endothelial cells to maintain normal vascular structures and regulate endothelial cell permeability by homology adhesion. New evidence indicates that certain invasive tumor cells also express VE‑cadherin, which is involved in vasculogenic mimicry to provide a blood supply required for tumor growth and metastasis. EC1 and EC3 domains of VE‑cadherin were reported to be important for intercellular homology adhesion. In the present study, a monoclonal antibody specific to the outer-membrane immunoglobulin-like domains of VE‑cadherin was generated and the binding epitope was identified as peptide LDREVVPWYNLTVEA in the EC4 domain...
April 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29684697/new-arene-ruthenium-ii-complexes-of-4%C3%A2-aryl%C3%A2-4h%C3%A2-naphthopyrans-with-anticancer-and-anti-vascular-activities
#7
Florian Schmitt, Jana Kasparkova, Viktor Brabec, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
A series of four 2‑amino‑3‑cyano‑4‑(3/4‑pyridyl)‑4H‑benzo[h]chromenes 2a-d and their dichlorido(p‑cymene)ruthenium(II) complexes 3a-d were tested for antiproliferative, vascular-disruptive, anti-angiogenic and DNA-binding activity. The coordination of the 4‑pyridyl‑4H‑naphthopyrans 2 to ruthenium led to complexes with pleiotropic effects. Unlike the free ligands 2a-d, their ruthenium complexes 3a-d showed a significant affinity for DNA as demonstrated by electrophoretic mobility shift assays (EMSA) and ethidium bromide assays...
April 5, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29660229/extracellular-matrix-composition-modulates-pdac-parenchymal-and-stem-cell-plasticity-and-behavior-through-the-secretome
#8
Giulia Biondani, Katrine Zeeberg, Maria Raffaella Greco, Stefania Cannone, Ilaria Dando, Elisa Dalla Pozza, Maria Mastrodonato, Stefania Forciniti, Valeria Casavola, Marta Palmieri, Stephan Joel Reshkin, Rosa Angela Cardone
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Its aggressiveness is driven by an intense fibrotic desmoplastic reaction in which the increasingly collagen I-rich extracellular matrix (ECM) and several cell types, including cancer stem cells (CSCs), create a tumor-supportive environment. However, how ECM composition regulates CSC dynamics and their relationship to the principal parenchymal tumor population to promote early invasive growth is not yet characterized. For this we utilized a platform of 3D organotypic cultures composed of laminin-rich Matrigel, representative of an early tumor, plus increasing concentrations of collagen I to simulate malignant stroma progression...
April 16, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29625446/quantitative-evaluation-of-vascular-microcirculation-using-contrast-enhanced-ultrasound-imaging-in-rabbit-models-of-choroidal-melanoma
#9
Min Gao, Jinhua Tang, Kun Liu, Ming Yang, Haiyun Liu
Purpose: We investigated the application of contrast-enhanced ultrasound (CEUS) to quantify vascular perfusion in two animal models of choroidal melanoma. Methods: B16F10 and choroidal melanoma cell line (OCM1) melanoma xenografts were implanted into the cyclodialysis cleft of rabbits' right eyes. Fundus photography, indocyanine green angiography (ICGA), B-mode ultrasound, and CEUS were used to examine the tumors. Standard vascular parameters of CEUS imaging were evaluated, including the area under the receiver operating characteristic curve (AUC), peak intensity (IMAX), mean transit time (mTT), rise time, and time to peak...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29576623/optoacoustics-delineates-murine-breast-cancer-models-displaying-angiogenesis-and-vascular-mimicry
#10
Isabel Quiros-Gonzalez, Michal R Tomaszewski, Sarah J Aitken, Laura Ansel-Bollepalli, Leigh-Ann McDuffus, Michael Gill, Lina Hacker, Joanna Brunker, Sarah E Bohndiek
BACKGROUND: Optoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to distinguish breast tumours displaying different vascular characteristics has yet to be established. The aim of the study is to prove OT as a sensitive technique for differentiating breast tumour models with manifestly different vasculatures. METHODS: Multispectral OT (MSOT) was performed in oestrogen-dependent (MCF-7) and oestrogen-independent (MDA-MB-231) orthotopic breast cancer xenografts...
March 26, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29561011/hypotoxic-copper-complexes-with-potent-anti-metastatic-and-anti-angiogenic-activities-against-cancer-cells
#11
Xiangchao Shi, Zhongyan Chen, Yanjun Wang, Zijian Guo, Xiaoyong Wang
Tumor metastasis and angiogenesis are the major obstacles in anticancer therapy. A series of phenanthroline copper(ii) complexes with different alkyl chains (CPTn, n = 1, 4, 6, 8) are synthesized and characterized. Cellular uptake and cytotoxicity assays reveal that the complex with longer chain length exhibits higher cellular Cu accumulation and stronger inhibition against the cancer cells. Both lipophilicity and structure influence the cellular uptake and cytotoxicity of CPTn. CPT8 is the most potent complex in this series...
March 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29535383/a-lats-biosensor-screen-identifies-vegfr-as-a-regulator-of-the-hippo-pathway-in-angiogenesis
#12
T Azad, H J Janse van Rensburg, E D Lightbody, B Neveu, A Champagne, A Ghaffari, V R Kay, Y Hao, H Shen, B Yeung, B A Croy, K L Guan, F Pouliot, J Zhang, C J B Nicol, X Yang
The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library of small molecule kinase inhibitors, we perform a screen for kinases modulating LATS activity and identify VEGFR as an upstream regulator of the Hippo pathway. We find that VEGFR activation by VEGF triggers PI3K/MAPK signaling, which subsequently inhibits LATS and activates the Hippo effectors YAP and TAZ...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29452694/chitinase-3-like-1-chi3l1-promotes-vasculogenic-mimicry-formation-in-cervical-cancer
#13
Nipaporn Ngernyuang, Rong Shao, Komsun Suwannarurk, Temduang Limpaiboon
Vasculogenic mimicry (VM) is an alternative microvascular system which tumour cells orchestrate, independent of endothelial cell-mediated angiogenesis. VM develops tumour vascular networks that correlate with tumour growth, metastasis, and short survival time of patients with a number of cancers. However, little is known regarding VM in the vascularisation of cervical cancer. Chitinase 3 like 1 (CHI3L1) has been previously reported to display the ability to induce angiogenesis in cervical cancer. Here, we explored a pathological role of CHI3L1 in tumour cell-mediated vascularisation...
April 2018: Pathology
https://www.readbyqxmd.com/read/29409810/foxf2-deficiency-permits-basal-like-breast-cancer-cells-to-form-lymphangiogenic-mimicry-by-enhancing-the-response-of-vegf-c-vegfr3-signaling-pathway
#14
Qing-Shan Wang, Rui He, Fan Yang, Li-Juan Kang, Xiao-Qing Li, Li Fu, Baocun Sun, Yu-Mei Feng
Lymphatic metastasis is the main route of breast cancer metastasis. It is known that lymphangiogenesis facilitates lymphatic metastasis through vascular endothelial growth factor-C (VEGF-C)/VEGF receptor 3 (VEGFR3) pathway-linked interactions between the tumor and its microenvironment. Here, we report a novel mechanism of lymphatic metastasis by which aggressive basal-like breast cancer (BLBC) cells form lymphatic vessel-like structures that are identified by the positive expression of lymphatic endothelial cell markers lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), podoplanin, and VEGFR3, and termed as lymphangiogenic mimicry (LM), for the first time...
April 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29387612/expression-of-vascular-endothelial-cadherin-in-mucoepidermoid-carcinoma-role-in-cancer-development
#15
Soussan Irani, Arash Dehghan
Objectives: Mucoepidermoid carcinoma (MEC) accounts for 35% of all malignant salivary gland tumors. Previous investigations have shown that vasculogenic mimicry (VM) exists in many cancers which can be used as a prognostic factor of poor prognosis. Elevated expression level of vascular endothelial (VE)-cadherin has been implicated in cancer neovascularization, growth, and progression. The current study aimed to study the presence of VE-cadherin in VM channels and tumor cells in different grades of MEC...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29378599/mir-3928v-is-induced-by-hbx-via-nf-%C3%AE%C2%BAb-egr1-and-contributes-to-hepatocellular-carcinoma-malignancy-by-down-regulating-vdac3
#16
Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li, Hua Tang
BACKGROUND: Hepatitis B virus (HBV) plays a critical role in the tumorigenic behavior of human hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have been reported to participate in HCC development via the regulation of their target genes. However, HBV-modulated miRNAs involved in tumorigenesis remain to be identified. Here, we found that a novel highly expressed miRNA, TLRC-m0008_3p (miR-3928v), may be an important factor that promotes the malignancy of HBV-related HCC. METHODS: Solexa sequencing was applied to profile miRNAs, and RT-qPCR was used to identify and quantitate miRNAs...
January 29, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29251531/micellar-formulations-of-crizotinib-and-dasatinib-in-the-management-of-glioblastoma-multiforme
#17
Khaled Greish, Anfal Jasim, Neha Parayath, Sara Abdelghany, Ali Alkhateeb, Sebastien Taurin, Hayley Nehoff
Glioblastoma multiforme (GBM) defies the currently practiced management of radiotherapy, chemotherapy and surgery and hence, it is associated with a high fatality rate with a median survival of 14.6 months. In our previous work investigating different tyrosine kinase inhibitors (TKIs), we established that a combination of Crizotinib and Dasatinib exerted the most potent effect on different GBM cell lines. In this work, to improve targeted therapy at the site of the tumour and avoid systemic toxicity, we exploited the enhanced permeability and retention effect by designing micellar formulations of these two TKIs...
December 27, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29238043/bcl-x-l-overexpression-promotes-tumor-progression-associated-properties
#18
Daniela Trisciuoglio, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Chiara Gabellini, Simonetta Buglioni, Matteo Pallocca, Gabriele Alessandrini, Simona D'Aguanno, Donatella Del Bufalo
By using human melanoma and glioblastoma cell lines and their derivative BCL-XL overexpressing clones, we investigated the role of BCL-XL in aggressive features of these two tumor histotypes. We found that in both models, BCL-XL overexpression increased in vitro cell migration and invasion and facilitated tumor cells to form de novo vasculogenic structures. Furthermore, BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29208325/inhibitory-effects-of-compound-dmbt-on-hypoxia-induced-vasculogenic-mimicry-in-human-breast-cancer
#19
Shuixian Li, Qianyun Zhang, Lichun Zhou, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han
Breast cancer is one of the most serious malignant tumors that harm to women's health. Vasculogenic mimicry (VM) is an alternative type of blood supplement independent of endothelial vessels, which refers to the formation of tumor cell-lined vessels and is associated with tumor invasion, metastasis and poor cancer patient prognosis. Prior antiangiogenic therapy just focused on vascular endothelial cells and did not significantly affect VM. DMBT, 6, 6'-bis (2, 3-dimethoxybenzoyl)-a, a-D-trehalose, has shown to have multiple anti-tumor invasion and metastasis activities; however the exact mechanism is not thoroughly elucidated...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29158813/vascularized-tissue-engineered-model-for-studying-drug-resistance-in-neuroblastoma
#20
A Villasante, K Sakaguchi, J Kim, N K Cheung, M Nakayama, H Parsa, T Okano, T Shimizu, G Vunjak-Novakovic
Neuroblastoma is a vascularized pediatric tumor derived from neural crest stem cells that displays vasculogenic mimicry and can express a number of stemness markers, such as SOX2 and NANOG. Tumor relapse is the major cause of succumbing to this disease, and properties attributed to cancer stem-like cells (CSLC), such as drug-resistance and cell plasticity, seem to be the key mechanisms. However, the lack of controllable models that recapitulate the features of human neuroblastoma limits our understanding of the process and impedes the development of new therapies...
2017: Theranostics
keyword
keyword
43921
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"