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https://www.readbyqxmd.com/read/29450641/chronic-lymphocytic-leukemia-cells-acquire-regulatory-b-cell-properties-in-response-to-tlr9-and-cd40-activation
#1
Shimrit Ringelstein-Harlev, Irit Avivi, Mona Fanadka, Netanel A Horowitz, Tami Katz
Circulating chronic lymphocytic leukemia (CLL) cells share phenotypic features with certain subsets of regulatory B-cells (Bregs). The latter cells have been reported to negatively regulate immune cell responses, mostly by provision of IL-10. The purpose of the current study was to identify and delineate Breg properties of CLL cells. B-cells and T-cells were obtained from the peripheral blood of untreated CLL patients diagnosed according to the 2008 Guidelines of the International Workshop on Chronic Lymphocytic Leukemia...
February 15, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29449556/cd1d-dependent-immune-suppression-mediated-by-regulatory-b-cells-through-modulations-of-inkt-cells
#2
K Oleinika, E C Rosser, D E Matei, K Nistala, A Bosma, I Drozdov, C Mauri
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29409312/impact-and-modulations-of-peripheral-and-edaphic-b-cell-subpopulations-in-chronic-rhinosinusitis-with-nasal-polyposis
#3
Pascal Ickrath, Norbert Kleinsasser, Xin Ding, Christian Ginzkey, Niklas Beyersdorf, Thomas Kerkau, Rudolf Hagen, Stephan Hackenberg
Objectives: The pathophysiological mechanisms of chronic rhinosinusitis with nasal polyposis (CRSwNP) still are discussed controversially. Regulatory B cells (Breg) are responsible for the suppression of T cell activity: deficiencies for Breg have been demonstrated to contribute to autoimmune disorders, e.g., systemic lupus erythematosus. In order to evaluate the influence of B cell subpopulations, especially Breg, on the etiology of this disease, the aim of this study was to characterize subpopulations of peripheral and edaphic B cells in CRSwNP...
February 8, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29371592/regulatory-b-cells-the-cutting-edge-of-immune-tolerance-in-kidney-transplantation
#4
REVIEW
Bo Peng, Yingzi Ming, Cheng Yang
Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great improvement has been achieved, immune tolerance is still the Holy Grail that every organ transplant practitioner pursues. The role of B cells in transplantation has long been considered simply to serve as precursors of plasma cells, which produce alloantibodies and induce antibody-mediated rejection. Recent research indicates that a specialized subset of B cells plays an important role in immune regulation, which has been well demonstrated in autoimmune diseases, infections, and cancers...
January 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29365321/immune-rebound-associates-with-a-favorable-clinical-response-to-autologous-hsct-in-systemic-sclerosis-patients
#5
Lucas C M Arruda, Kelen C R Malmegrim, João R Lima-Júnior, Emmanuel Clave, Juliana B E Dias, Daniela A Moraes, Corinne Douay, Isabelle Fournier, Hélène Moins-Teisserenc, Antônio José Alberdi, Dimas T Covas, Belinda P Simões, Pauline Lansiaux, Antoine Toubert, Maria Carolina Oliveira
To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) cell immune reconstitution, 31 systemic sclerosis (SSc) patients underwent simultaneous clinical and immunological evaluations over 36-month posttransplantation follow-up. Patients were retrospectively grouped into responders (n = 25) and nonresponders (n = 6), according to clinical response after AHSCT. Thymic function and B-cell neogenesis were respectively assessed by quantification of DNA excision circles generated during T- and B-cell receptor rearrangements...
January 23, 2018: Blood Advances
https://www.readbyqxmd.com/read/29352085/the-expression-of-bacteriocin-production-and-self-resistance-in-lactobacillus-brevis-174a-is-mediated-by-two-regulatory-proteins
#6
Masafumi Noda, Rumi Miyauchi, Narandalai Danshiitsoodol, Yasuyuki Matoba, Takanori Kumagai, Masanori Sugiyama
We have previously shown that a lactic acid bacterium Lactobacillus (Lb.) brevis 174A isolated from a Citrus iyo fruit produces bacteriocin designated brevicin 174A, which is comprised of two antibacterial polypeptides (designated brevicin 174A-β and 174A-γ). We have also found a gene cluster, composed of eight open reading frames (ORFs), that contains genes for the biosynthesis of brevicin 174A, self-resistance to its own bacteriocin, and two transcriptional regulatory proteins.Some lactic acid bacterial strains have a system to start the production of bacteriocin at an adequate stage of the growth...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29349658/the-il-10-producing-regulatory-b-cells-b10-cells-and-regulatory-t-cell-subsets-in-neuromyelitis-optica-spectrum-disorder
#7
Eun Bin Cho, Hye-Jin Cho, Jin Myoung Seok, Ju-Hong Min, Eun-Suk Kang, Byoung Joon Kim
B cells contribute to the pathogenesis of neuromyelitis optica (NMO) by producing Aquaporin 4-specific autoantibodies (AQP4-ab); on the other hand, there are certain B cells that suppress immune responses by producing regulatory cytokines, such as IL-10. In this study, we investigated the presence of IL-10-producing Breg cells among lymphocyte subsets. Twenty-two seropositive NMO spectrum disorder (NMOSD) patients (29 samples) and 13 healthy controls (HCs) (14 samples) were enrolled. All NMOSD patients have received one or more immunosuppressive drugs...
January 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29338551/the-regulatory-roles-of-b-cell-subsets-in-transplantation
#8
Zhulang Chu, Weilong Zou, Yanan Xu, Qiquan Sun, Yong Zhao
B cells mediate allograft rejection through antigen presentation, and production of cytokines and antibodies. More and more immunosuppressive agents specifically targeting B cells and plasma cells have been applied in clinical transplantation. However, recent studies have indicated the regulatory roles of B cells. Therefore, it is vital to clarify the different effects of B cell subsets in organ transplantation so that we can completely understand the diverse functions of B cells in transplantation. Areas covered: This review focuses on the regulatory roles of B cells in transplantation...
January 17, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29338084/importance-of-b-cells-to-development-of-regulatory-t-cells-and-prolongation-of-tissue-allograft-survival-in-recipients-receiving-autologous-bone-marrow-transplantation
#9
Reginald M Gorczynski, Kaveh Farrokhi, Christopher Gorczynski, Hassan Sadozai, Fang Zhu, Ismat Khatri
We previously showed that congenic bone marrow transplantation (BMTx) post myeloablation augmented tissue allograft survival in association with increased regulatory T (Treg) cells of both host and bone marrow donor origin. Regulatory B (Breg) cells can also modulate T-cell immunity and B cells may be implicated in the development of Treg cells. Accordingly, we explored the effect of B-cell depletion in vivo on augmented graft survival post BMTx. C57BL/6 mice received BALB/c skin allografts followed 7 days later by myeloablation using cyclophosphamide and busulphan...
January 16, 2018: Immunology
https://www.readbyqxmd.com/read/29335495/dysfunction-of-cd19-cd24hicd27-b-regulatory-cells-in-patients-with-bullous-pemphigoid
#10
Zhenfeng Liu, Erle Dang, Bing Li, Hongjiang Qiao, Liang Jin, Jieyu Zhang, Gang Wang
Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the production of autoantibodies against the hemidesmosomal protein BP180. B regulatory cells (Bregs) are crucial in maintaining self-tolerance and suppressing autoantibody production. However, it is still unclear whether the dysfunctions of Bregs contributes to the autoantibody production in BP patients. In this study, we found that CD19+CD24hiCD27+ Bregs and IL-10+CD19+ Bregs were significantly increased in the peripheral blood samples of BP patients compared with that in healthy controls...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324739/mansonella-perstans-microfilaremic-individuals-are-characterized-by-enhanced-type-2-helper-t-and-regulatory-t-and-b-cell-subsets-and-dampened-systemic-innate-and-adaptive-immune-responses
#11
Manuel Ritter, Winston Patrick Chounna Ndongmo, Abdel Jelil Njouendou, Nora Nganyewo Nghochuzie, Lucy Cho Nchang, Dizzle Bita Tayong, Kathrin Arndts, Norman Nausch, Marc Jacobsen, Samuel Wanji, Laura E Layland, Achim Hoerauf
The filarial nematode Mansonella perstans is endemic throughout Africa, northern South America and the Caribbean. Interestingly, M. perstans-infected individuals present no distinct clinical picture associated with certain pathology. Due to its relatively silent nature, research on this tropical disease has been neglected, especially M. perstans-driven immune responses. A hindrance in obtaining data on M. perstans-specific responses has been the inability to obtain adult worms since their habitats in serous cavities are difficult to access...
January 11, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29313944/regulatory-b-cells-in-experimental-stroke
#12
REVIEW
Hilary A Seifert, Arthur A Vandenbark, Halina Offner
Current treatment options for human stroke are limited mainly to the modestly effective infusion of tissue plasminogen activator (tPA), with additional improvement of functional independence and higher rates of angiographic revascularization observed after mechanical thrombectomy. However, new therapeutic strategies that address post-stroke immune-mediated inflammatory responses are urgently needed. Recent studies in experimental stroke have firmly implicated immune mechanisms in the propagation and partial resolution of CNS damage after the ischemic event...
January 3, 2018: Immunology
https://www.readbyqxmd.com/read/29306980/sex-in-respiratory-and-skin-allergies
#13
REVIEW
Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Marco Caminati, Giorgio Walter Canonica, Gianenrico Senna
A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune response of female hormones and in particular the modulation of inflammatory response by estrogens, as well as the result of the activity of various cells, such as dendritic cells, innate lymphoid cells, Th1, Th2, T regulatory (Treg) and B regulatory (Bregs) cells, and a number of proteins and cytokines, which include interleukin (IL)-4, IL-5, IL-10, and IL-13...
January 6, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29259988/increased-circulating-th17-but-decreased-cd4-foxp3-treg-and-cd19-cd1dhicd5-breg-subsets-in-new-onset-graves-disease
#14
Jing Qin, Jin Zhou, Chenling Fan, Na Zhao, Yongping Liu, Shuo Wang, Xuejiao Cui, Mingshi Huang, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Th17 and regulatory lymphocyte subsets such as Tregs and Bregs have been reported to play important roles in autoimmune diseases. The aim of this work was to perform quantitative studies of circulating Th17, Tregs, and Bregs in patients with new-onset Graves' disease (GD). Twenty GD patients and 20 healthy controls were involved in this study. Blood samples were taken for flow cytometry detection of CD4+IL-17+ Th17, CD4+Foxp3+ Tregs, and CD19+CD1dhiCD5+ Bregs and meanwhile, for real-time PCR measurement of gene expressions of RORγt, IL-17 and IL-10...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29221714/changes-in-regulatory-b-cell-levels-in-bone-marrow-blood-and-sputum-of-asthmatics-following-inhaled-allergen-challenge
#15
John-Paul Oliveria, Amani I El-Gammal, Michelle Yee, Caitlin D Obminski, Tara X Scime, Rick M Watson, Karen Howie, Paul M O'Byrne, Roma Sehmi, Gail M Gauvreau
Following allergen exposure in the airways of subjects with allergic asthma, Bregs appear to efflux from the bone marrow and accumulate in the lungs with a possible role in dampening local inflammatory responses.
December 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29212210/mir-21-silencing-ameliorates-experimental-autoimmune-encephalomyelitis-by-promoting-the-differentiation-of-il-10-producing-b-cells
#16
Hui Wang, Wenrong Xu, Qixiang Shao, Qing Ding
IL-10-producing regulatory B (IL-10+ Breg) cells promote tolerance in autoimmune diseases and transplantation. However, it remains unclear whether microRNAs are involved in the development of IL-10+ Breg cells. Here, we found that microRNA-21 (miR-21) acts as an upstream regulator of IL-10 by targeting the 3' untranslated region of IL-10 mRNA. We also demonstrated that IL-10+ Breg cells exhibit lower miR-21 expression than non-Breg cells and that miR-21 acts as a potent negative regulator of the differentiation of IL-10+ Breg cells...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29077695/human-b-regulatory-cells-the-new-players-in-autoimmune-disease
#17
José L Maravillas-Montero, Ernesto Acevedo-Ochoa
Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses, specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently. These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in development B-cell targeted therapies seem to be ideal treatments for different types of diseasessuch as cancer and allergy...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29051763/il-12p35-inhibits-neuroinflammation-and-ameliorates-autoimmune-encephalomyelitis
#18
Jin Kyeong Choi, Ivy M Dambuza, Chang He, Cheng-Rong Yu, Anita N Uche, Mary J Mattapallil, Rachel R Caspi, Charles E Egwuagu
Multiple sclerosis (MS) is an inflammatory demyelinating disease in which cytokines produced by immune cells that infiltrate the brain and spinal cord play a central role. We show here that the IL-12p35, the alpha subunit of IL-12 or IL-35 cytokine, might be an effective biologic for suppressing neuroinflammatory responses and ameliorating the pathology of experimental autoimmune encephalomyelitis (EAE), the mouse model of human MS. We further show that IL-12p35 conferred protection from neuropathy by inhibiting the expansion of pathogenic Th17 and Th1 cells and inhibiting trafficking of inflammatory cells into the brain and spinal cord...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29046188/association-of-imbalance-of-effector-t-cells-and-regulatory-cells-with-the-severity-of-asthma-and-allergic-rhinitis-in-children
#19
Fei Huang, Jia-Ning Yin, Hong-Bo Wang, Shou-Yue Liu, Ya-Nan Li
PURPOSE: This study investigated the frequency and absolute numbers of different subsets of peripheral blood cells, including CD4+ T cells and CD19+ interleukin (IL) 10+ B regulatory cells (Breg) and their potential association with clinical laboratory measurements in children diagnosed with simple asthma or asthma plus allergic rhinitis (AR). METHOD: The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29042997/cd19-cd24-hi-cd38-hi-regulatory-b-cells-are-associated-with-insulin-resistance-in-type-i-hashimoto-s-thyroiditis-in-chinese-females
#20
Min Yang, Changji Du, Yinping Wang, Jun Liu
Hashimoto's thyroiditis (HT) is typically associated with insulin resistance. The aim of the present study was to investigate the role of regulatory B cells (Bregs) in insulin resistance in patients with HT. A total of 52 female patients with type I HT and 35 matched healthy volunteers were enrolled. Demographic and laboratorial data were collected. A 75 g oral glucose tolerance test was performed on each subject. Flow cytometry was performed to evaluate the levels of CD19(+)CD24(hi)CD38(hi) Bregs in peripheral blood...
October 2017: Experimental and Therapeutic Medicine
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