Tatsuzo Mishina, Hiroaki Miyoshi, Mai Takeuchi, Kohta Miyawaki, Kazutaka Nakashima, Kyohei Yamada, Mayuko Moritsubo, Kanako Inoue-Mitsuyama, Yasumasa Shimasaki, Teppei Imamoto, Keisuke Kawamoto, Takuya Furuta, Kei Kohno, Koji Kato, Koichi Akashi, Koichi Ohshima
Regulatory B cells (Bregs) suppress antitumor immunity by producing anti-inflammatory cytokines such as transforming growth factor β (TGF-β) and interleukin-10 (IL-10) and promoting tumor growth. It is unknown whether diffuse large B-cell lymphoma (DLBCL), a common subtype of B-cell malignancy, exhibits characteristics similar to those of Bregs. This study aimed to clarify the features of DLBCLs carrying Breg markers. In 123 DLBCL cases, we evaluated TGF-β and IL-10 expression in tumor biopsy samples using immunohistochemical staining and retrospectively analyzed their clinicopathological characteristics...
January 10, 2024: Pathology, Research and Practice