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https://www.readbyqxmd.com/read/28944997/desire-for-parenthood-and-reproductive-health-knowledge-in-adolescents-and-young-adults-with-sickle-cell-disease-and-their-caregivers
#1
Leena Nahata, Nicole M Caltabellotta, Kyle Ball, Sarah H O'Brien, Susan E Creary
BACKGROUND/OBJECTIVE: Sickle cell disease (SCD) and hydroxyurea have implications for fertility and reproductive health. The goal of this study was to examine desire for parenthood and reproductive health knowledge among a cohort of adolescent and young adult (AYA) with SCD receiving hydroxyurea and their caregivers at a large pediatric academic center. METHODS: Patients with SCD were approached from September 2016 to July 2017 if they were: (1) 12-20 years old, (2) prescribed hydroxyurea for at least 6 months, (3) proficient in English, and (4) accompanied by a caregiver who was proficient in English and willing to participate...
September 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944717/an-overview-of-assessment-methodology-for-obesity-related-variables-in-infants-at-risk
#2
Danae Dinkel, Corrine Hanson, Karsten Koehler, Ann Anderson Berry, Anastasia Kyvelidou, Matthew Bice, Jill Wallen, Danstan Bagenda, Laura Jana, Jana Pressler
BACKGROUND: The first 2 years of a child's life are a particularly critical time period for obesity prevention. AIM: An increasing amount of research across the world is aimed at understanding factors that impact early childhood obesity and developing interventions that target these factors effectively. With this growing interest, new and interdisciplinary research teams are developing to meet this research need. Due to rapid growth velocity during this phase of the lifespan, typical assessments used in older populations may not be valid or applicable in infants, and investigators need to be aware of the pros and cons of specific methodological strategies...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28944621/factors-associated-with-ohio-nurse-practitioners-childhood-obesity-preventive-practice-patterns
#3
Rika Tanda, Elizabeth A Beverly, Kimberly Hughes
BACKGROUND AND PURPOSE: More nurse practitioners (NPs) infiltrate into primary care settings, and play a pivotal role in prevention of childhood obesity. However, minimal research has been published about their practice patterns. The current study uses a sample of Ohio NPs and describes NPs' childhood obesity prevention practice patterns, knowledge of the guidelines, their personal physical activity in relation to childhood obesity prevention practices, and identification of perceived barriers for practice...
September 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28944605/a-comparison-of-two-screening-tools-for-paediatric-obstructive-sleep-apnea
#4
Asmaa M Abumuamar, Sharon A Chung, Gili Kadmon, Colin M Shapiro
Untreated obstructive sleep apnea in children is associated with significant medical and psychological morbidities. Polysomnographic testing is the gold-standard method for diagnosis of obstructive sleep apnea. However, laboratory-based polysomnography is expensive and associated with a substantial healthcare burden. Thus, a simple valid tool to accurately identify those at high risk of obstructive sleep apnea is essential. We performed a retrospective cross-sectional study of children referred to the Youthdale Child and Adolescent Sleep Clinic...
September 25, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28944600/digital-disruption-maternal-mobile-device-use-is-related-to-infant-social-emotional-functioning
#5
Sarah Myruski, Olga Gulyayeva, Samantha Birk, Koraly Pérez-Edgar, Kristin A Buss, Tracy A Dennis-Tiwary
Mobile device use has become increasingly prevalent, yet its impact on infant development remains largely unknown. When parents use mobile devices in front of infants, the parent is physically present but most likely distracted and unresponsive. Research using the classic Still Face Paradigm (SFP) suggests that parental withdrawal and unresponsiveness may have negative consequences for children's social-emotional development. In the present study, 50 infants aged 7.20 to 23.60 months (M = 15.40, SD = 4.74) and their mothers completed a modified SFP...
September 24, 2017: Developmental Science
https://www.readbyqxmd.com/read/28944592/estimating-the-prevalence-of-borderline-personality-disorder-in-mothers-involved-in-youth-protection-services
#6
Lise Laporte, Joel Paris, Phyllis Zelkowitz
Characteristics of borderline personality disorder (BPD) can undermine maternal capacity and in some cases lead to involvement with youth protection services (YPS). Yet, few studies exist on the prevalence of maternal BPD in this context and on the comparison of these families with families with other maternal psychiatric disorders or families with no mental illness within YPS. The current study surveyed 291 caseworkers working with mothers whose children and adolescents are followed by YPS. After reported prevalence was adjusted with validation procedures, the prevalence of maternal BPD in a sample of 1875 mothers was 34...
September 24, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28944533/parents-spend-an-average-of-nine-hours-a-day-providing-palliative-care-for-children-at-home-and-need-to-maintain-an-average-of-five-life-saving-devices
#7
P Lazzarin, B Schiavon, L Brugnaro, F Benini
AIM: This Italian study investigated home-based palliative care for young children and how long it took parents to meet their needs. METHODS: The study population consisted of 33 families with a child under the responsibility of the Veneto Regional Center for Pediatric Palliative Care, northern Italy, who needed medical support in at least two of the following areas: respiratory, feeding, pain and seizures. RESULTS: The children had a mean age of 6...
September 25, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28944500/social-cognitive-and-physiological-aspects-of-humour-perception-from-4-to-8-months-two-longitudinal-studies
#8
Gina C Mireault, Susan C Crockenberg, Keri Heilman, John E Sparrow, Kassandra Cousineau, Brady Rainville
Infants laugh by 4 months, but whether they understand humour based on social or cognitive factors is unclear. We conducted two longitudinal studies of 4-, 6-, and 8-month-olds (N = 60), and 5-, 6-, and 7-month-olds (N = 53) to pinpoint the onset of independent humour perception and determine when social and cognitive factors are most salient. Infants were shown six events in randomized repeated-measures designs: two ordinary events and two absurd iterations of those events, with parents' affect manipulated (laugh or neutral) during the latter...
September 25, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28944293/preventing-caries-in-american-indian-children-lost-battle-or-new-hope
#9
J Albino, T S Batliner, T Tiwari
Knowledge Transfer Statement: Preventing early childhood caries in American Indian children has proved to be an unexpectedly challenging goal. Biological and behavioral variables, as well as parental psychosocial characteristics and experiences, suggest new routes for understanding and mitigating the progress of disease. We provide our reflections after a decade of studying these issues in collaboration with tribal communities.
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28944292/early-head-start-pediatric-dental-use-and-oral-health-related-quality-of-life
#10
J M Burgette, J S Preisser, M Weinberger, R S King, R G Rozier
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). In total, 479 parents of children enrolled in EHS and 699 parents of Medicaid-matched children were interviewed at baseline when children were approximately 10 mo old and 24 mo later. In this quasi-experimental study, mediation analysis was performed using the counterfactual framework analysis, which employed 2 logit models with random effects: 1) for the mediator as a function of the treatment and covariates and 2) for the outcome as a function of the treatment, mediator, and covariates...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28944283/how-does-legal-status-matter-for-oral-health-care-among-mexican-origin-children-in-california
#11
R S Oropesa, Nancy S Landale, Marianne M Hillemeier
This research examines the relationship between legal status and oral health care among Mexican-origin children. Using the 2001-2014 California Health Interview Surveys, the objectives are: (1) to demonstrate population-level changes in the legal statuses of parents, the legal statuses of children, and the likelihood of receiving dental care; (2) to reveal how the roles of legal status boundaries in dental care are changing; and (3) to determine whether the salience of these boundaries is attributable to legal status per se...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/28944258/the-effect-of-paternal-and-alloparental-support-on-the-interbirth-interval-among-contemporary-north-american-families
#12
Nóra Szabó, Judith Semon Dubas, Brenda L Volling, Marcel A G van Aken
The present study investigated whether the length of interbirth intervals between first and second-born children in a North-American middle-class sample could be explained by paternal and alloparental support and firstborn children's gender. The sample consisted of 225 families in which mothers were expecting their second child. Parents reported on paternal and alloparental support (maternal kin, paternal kin, and non-kin support). The results showed that higher maternal kin support and having a firstborn son was linked with shorter interbirth-intervals...
July 2017: Evol Behav Sci
https://www.readbyqxmd.com/read/28944244/inherited-2q23-1-microdeletions-involving-the-mbd5-locus
#13
Shereen Tadros, Rubin Wang, Jonathan J Waters, Christine Waterman, Amanda L Collins, Morag N Collinson, Joo W Ahn, Dragana Josifova, Ravi Chetan, Ajith Kumar
BACKGROUND: Microdeletions of 2q23.1 disrupting MBD5 and loss of function mutations of MBD5 cause MBD5-Associated Neurodevelopmental disorders (MAND). Nearly all reported patients have been isolated cases of de novo origin. METHODS: This study investigates three families with inherited MBD5 mutations from three different Regional Genetics Centres in the UK. RESULTS: Two of the parents in the study had MBD5 deletions in a mosaic form. The parent with an MBD5 deletion in an apparently nonmosaic form has a psychiatric disorder in the absence of developmental delay or dysmorphism...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944231/1993-2014-two-decades-of-predictive-testing-for-huntington-s-disease-at-the-medical-genetics-unit-of-the-university-of-genoa
#14
Paola Mandich, Merit Lamp, Fabio Gotta, Rossella Gulli, Ariela Iacometti, Roberta Marchese, Emilia Bellone, Giovanni Abbruzzese, Giovanna Ferrandes
BACKGROUND: Predictive testing for Huntington's disease has been available at the Medical Genetics Unit of the University of Genoa from 1987. In 1989, an integrated counseling protocol (geneticist, psychologist, and neurologist) was developed following International Guidelines. METHODS: This is a retrospective analysis of the clinical charts and motivation questionnaires of persons seeking predictive testing through direct DNA analysis from 1993 until 2014, with the aim to evaluate their individual characteristics, motivations, and the outcomes of the counseling protocol...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944224/the-relationship-between-parental-rearing-behavior-resilience-and-depressive-symptoms-in-adolescents-with-congenital-heart-disease
#15
Ju Ryoung Moon, Jinyoung Song, June Huh, I-Seok Kang, Seung Woo Park, Sung-A Chang, Ji-Hyuk Yang, Tae-Gook Jun
OBJECTIVES: Parental rearing behavior is one factor that influences the strength of resilience. In turn, resilience influences depression. However, it is unclear whether resilience has a mediating effect on the relationship between parental rearing and depression in adolescents with congenital heart disease (CHD). Therefore, the associations between parental rearing behavior and resilience and between rearing behavior and symptoms of depression were investigated with respect to age, gender and disease severity...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28944023/genetic-conservation-and-management-of-the-california-endemic-torrey-pine-pinus-torreyana-parry-implications-of-genetic-rescue-in-a-genetically-depauperate-species
#16
Jill A Hamilton, Raphaël Royauté, Jessica W Wright, Paul Hodgskiss, F Thomas Ledig
Rare species present a challenge under changing environmental conditions as the genetic consequences of rarity may limit species ability to adapt to environmental change. To evaluate the evolutionary potential of a rare species, we assessed variation in traits important to plant fitness using multigenerational common garden experiments. Torrey pine, Pinus torreyana Parry, is one of the rarest pines in the world, restricted to one mainland and one island population. Morphological differentiation between island and mainland populations suggests adaptation to local environments may have contributed to trait variation...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943970/ethical-legal-and-social-issues-in-japan-on-the-determination-of-blood-relationship-via-dna-testing
#17
Waki Toya
DNA paternity testing has recently become more widely available in Japan. The aim of this paper is to examine the issues surrounding (1) the implementing agency, whether the testing is conducted in a commercial direct-to-consumer (DTC) setting or a judicial non-DTC setting, and (2) the implementation conditions and more specifically the legal capacity of the proband (test subject). Literature research in Japanese and English was conducted. Some countries prohibit commercial DNA testing without the consent of the proband or her or his legally authorized representative...
2017: Asian Bioeth Rev
https://www.readbyqxmd.com/read/28943930/downregulation-of-cytochrome-c-oxidase-1-induced-radioresistance-in-esophageal-squamous-cell-carcinoma
#18
Tomoko Takesue, Hirofumi Kawakubo, Tetsu Hayashida, Mai Tsutsui, Kazuhiro Miyao, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hiroya Takeuchi, Yuko Kitagawa
Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another location in the genome at random. By inserting the cytomegalovirus promotor as a transcriptional activator in the transposon, the following gene in the new location becomes overexpressed and the gene located at the transposon insertion site is downregulated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943864/evolutionary-engineering-in-chemostat-cultures-for-improved-maltotriose-fermentation-kinetics-in-saccharomyces-pastorianus-lager-brewing-yeast
#19
Anja Brickwedde, Marcel van den Broek, Jan-Maarten A Geertman, Frederico Magalhães, Niels G A Kuijpers, Brian Gibson, Jack T Pronk, Jean-Marc G Daran
The lager brewing yeast Saccharomyces pastorianus, an interspecies hybrid of S. eubayanus and S. cerevisiae, ferments maltotriose, maltose, sucrose, glucose and fructose in wort to ethanol and carbon dioxide. Complete and timely conversion ("attenuation") of maltotriose by industrial S. pastorianus strains is a key requirement for process intensification. This study explores a new evolutionary engineering strategy for improving maltotriose fermentation kinetics. Prolonged carbon-limited, anaerobic chemostat cultivation of the reference strain S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943860/bumetanide-as-a-candidate-treatment-for-behavioral-problems-in-tuberous-sclerosis-complex
#20
Chantal Vlaskamp, Simon-Shlomo Poil, Floor Jansen, Klaus Linkenkaer-Hansen, Sarah Durston, Bob Oranje, Hilgo Bruining
BACKGROUND: Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION: Here, we used the chloride transporter antagonist bumetanide to treat a female adolescent TSC patient with refractory seizures, sensory hyper-reactivity, and a variety of repetitive and compulsive behaviors...
2017: Frontiers in Neurology
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