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https://www.readbyqxmd.com/read/29786868/cis-acting-allele-specific-expression-ase-differences-induced-by-alcohol-and-impacted-by-sex-as-well-as-parental-genotype-of-origin
#1
Chiao-Ling Lo, Lawrence Lumeng, Richard L Bell, Tiebing Liang, Amy C Lossie, Williams M Muir, Feng C Zhou
BACKGROUND: Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high and low alcohol drinking (HAD and LAD) rat lines. Here we report allele specific expression (ASE) differences, between the HAD2 and LAD2 rat lines. METHODS: The HAD2 and LAD2 rats which have been sequenced were reciprocally crossed to generate 10 litters of F1 progeny...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786712/cocrystals-of-a-1-2-4-thiadiazole-based-potent-neuroprotector-with-gallic-acid-solubility-thermodynamic-stability-relationships-and-formation-pathways
#2
Artem O Surov, Andrei V Churakov, Alexey N Proshin, Xia-Lin Dai, Tongbu Lu, German L Perlovich
Three distinct solid forms, namely anhydrous cocrystals with 2 : 1 and 1 : 1 drug/acid ratios ([TDZ : GA] (2 : 1), [TDZ : GA] (1 : 1)), and a hydrated one having 1 : 1 : 1 drug/acid/water stoichiometry ([TDZ : GA : H2O] (1 : 1 : 1)), have been formed by cocrystallization of the biologically active 1,2,4-thiadiazole derivative (TDZ) with gallic acid (GA). The thermodynamic stability relationships between the cocrystals were rationalized in terms of Gibbs energies of the formation reactions and further verified by performing a set of competitive and exchange mechanochemical reactions...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29786663/modeling-the-effect-of-primary-and-secondary-twinning-on-texture-evolution-during-severe-plastic-deformation-of-a-twinning-induced-plasticity-steel
#3
Laszlo S Toth, Christian Haase, Robert Allen, Rimma Lapovok, Dmitri A Molodov, Mohammed Cherkaoui, Haitham El Kadiri
Modeling the effect of deformation twinning and the ensuing twin-twin- and slip-twin-induced hardening is a long-standing problem in computational mechanical metallurgy of materials that deform by both slip and twinning. In this work, we address this effect using the twin volume transfer method, which obviates the need of any cumbersome criterion for twin variant selection. Additionally, this method is capable of capturing, at the same time, secondary or double twinning, which is particularly important for modeling in large strain regimes...
May 22, 2018: Materials
https://www.readbyqxmd.com/read/29786647/health-disparities-score-composite-of-youth-and-parent-dyads-from-an-obesity-prevention-intervention-icook-4-h
#4
Melissa D Olfert, Makenzie L Barr, Rebecca L Hagedorn, Lisa Franzen-Castle, Sarah E Colby, Kendra K Kattelmann, Adrienne A White
iCook 4-H is a lifestyle intervention to improve diet, physical activity and mealtime behavior. Control and treatment dyads (adult primary meal preparer and a 9⁻10-year-old youth) completed surveys at baseline and 4, 12, and 24 months. A Health Disparity (HD) score composite was developed utilizing a series of 12 questions (maximum score = 12 with a higher score indicating a more severe health disparity). Questions came from the USDA short form U.S. Household Food Security Survey (5), participation in food assistance programs (1), food behavior (2), level of adult education completed (1), marital status (1), and race (1 adult and 1 child)...
May 22, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29786583/incidence-and-risk-factors-of-spina-bifida-in-children
#5
Mariana O Ryznychuk, Mariana I Kryvchanska, Irina V Lastivka, Roman Ye Bulyk
OBJECTIVE: Introduction: The pathogenesis of spina bifida depends on time, region, race and ethnicity. It is found in 4.7 per 10.000 of live born children worldwide. The aim: The incidence in children of Northern Bukovina was analyzed. The spina bifida incidence for 2007-2016 in this region, as well as, compared to some countries according to EUROCAT data was studied. PATIENTS AND METHODS: Materials and methods: A retrospective study to analyze the risk factors for spina bifida was carried out...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786554/a-human-ipsc-line-capable-of-differentiating-into-functional-macrophages-expressing-zsgreen-a-tool-for-the-study-and-in-vivo-tracking-of-therapeutic-cells
#6
Martha Lopez-Yrigoyen, Antonella Fidanza, Luca Cassetta, Richard A Axton, A Helen Taylor, Jose Meseguer-Ripolles, Anestis Tsakiridis, Valerie Wilson, David C Hay, Jeffrey W Pollard, Lesley M Forrester
We describe the production of a human induced pluripotent stem cell (iPSC) line, SFCi55-ZsGr, that has been engineered to express the fluorescent reporter gene, ZsGreen, in a constitutive manner. The CAG-driven ZsGreen expression cassette was inserted into the AAVS1 locus and a high level of expression was observed in undifferentiated iPSCs and in cell lineages derived from all three germ layers including haematopoietic cells, hepatocytes and neurons. We demonstrate efficient production of terminally differentiated macrophages from the SFCi55-ZsGreen iPSC line and show that they are indistinguishable from those generated from their parental SFCi55 iPSC line in terms of gene expression, cell surface marker expression and phagocytic activity...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786547/protective-effect-of-breastfeeding-on-recurrent-cough-in-adulthood
#7
Kimberly D Gerhart, Debra A Stern, Stefano Guerra, Wayne J Morgan, Fernando D Martinez, Anne L Wright
RATIONALE: Breastfeeding protects from respiratory infections in early life but its relationship to recurrent cough and other respiratory outcomes in adult life is not well established. METHODS: Infant feeding practices were assessed prospectively in the Tucson Children's Respiratory Study, a non-selected birth cohort and categorised into formula from birth or introduced <1 month, formula introduced ≥1 to <4 months and exclusive breastfeeding for ≥4 months...
May 21, 2018: Thorax
https://www.readbyqxmd.com/read/29786515/research-brief-persistent-social-inequality-in-medicine-use-for-headache-among-adolescents-in-denmark-1991-2014
#8
Bjørn Evald Holstein, Anne Maj Denbæk, Anette Andersen, Pernille Due
BACKGROUND: Socioeconomic variation in adolescents' medicine use behaviour is an understudied issue. OBJECTIVES: To examine the association between socioeconomic background and medicine use for headache among adolescents, and how this association changes over time. METHODS: Data stem from the Danish part of the international Health Behaviour in School-aged Children (HBSC) study 1991-2014 with data about parents' occupational social class (OSC) and self-reported medicine use for headache, n = 26,685...
May 18, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29786146/awareness-of-and-phobias-about-topical-corticosteroids-in-parents-of-infants-with-eczema-in-hangzhou-china
#9
Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng
BACKGROUND/OBJECTIVES: Knowledge of and phobias about topical corticosteroids in parents of infants with eczema affect efficacy of eczema treatment. METHODS: We surveyed 300 parents of children with eczema using a questionnaire to investigate knowledge of and phobias about topical corticosteroids. RESULTS: Overall, 85.7% (n = 257) of children had used topical corticosteroids, with 12.8% (n = 33) of children having steroids applied for only 1-3 days per episode; 79...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29786090/crispr-off-target-analysis-in-genetically-engineered-rats-and-mice
#10
Keith R Anderson, Maximilian Haeussler, Colin Watanabe, Vasantharajan Janakiraman, Jessica Lund, Zora Modrusan, Jeremy Stinson, Qixin Bei, Andrew Buechler, Charles Yu, Sobha R Thamminana, Lucinda Tam, Michael-Anne Sowick, Tuija Alcantar, Natasha O'Neil, Jinjie Li, Linda Ta, Lisa Lima, Merone Roose-Girma, Xin Rairdan, Steffen Durinck, Søren Warming
Despite widespread use of CRISPR, comprehensive data on the frequency and impact of Cas9-mediated off-targets in modified rodents are limited. Here we present deep-sequencing data from 81 genome-editing projects on mouse and rat genomes at 1,423 predicted off-target sites, 32 of which were confirmed, and show that high-fidelity Cas9 versions reduced off-target mutation rates in vivo. Using whole-genome sequencing data from ten mouse embryos, treated with a single guide RNA (sgRNA), and from their genetic parents, we found 43 off-targets, 30 of which were predicted by an adapted version of GUIDE-seq...
May 21, 2018: Nature Methods
https://www.readbyqxmd.com/read/29785948/-genetics-of-fertility-restoration-in-the-isocytoplasm-allonuclear-c-group-of-cytoplasmic-male-sterility-in-maize
#11
Zhuo Fan Zhao, Ling Huang, Yong Ming Liu, Peng Zhang, Gui Wei, Mo Ju Cao
Maize is one of the first crops to produce hybrids using cytoplasmic male sterile lines. The C-type cytoplasmic male sterile (CMS-C) line is vital for hybrid seed production, and the fertility-restoration reaction along with its stability has a direct bearing on its applications. However, fertility restoration mechanism of CMS-C is complex and is still not clear so far. To further explore the factors affecting the fertility restoration of maize CMS, a series of test crosses were carried out by pollinating the isocytoplasm allonuclear CMS-C lines C48-2, Chuangzaosi and C478 with the test lines 18 bai, zi 330, 5022 and the restorer line A619, respectively...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785798/parent-mediated-intervention-training-delivered-remotely-for-children-with-autism-spectrum-disorder-asd-has-preliminary-evidence-for-parent-intervention-fidelity-and-improving-parent-knowledge-and-children-s-social-behaviour-and-communication-skills
#12
https://www.readbyqxmd.com/read/29785743/four-new-diterpenoid-alkaloids-from-the-roots-of-aconitum-carmichaelii
#13
Yu Li, Feng Gao, Ji-Fa Zhang, Xian-Li Zhou
Aconitum carmichaelii, belonging to the Ranunculaceae family, is mainly distributed and cultivated in southwestern China. Its parent and lateral roots, two well-known traditional medicinal materials, are commonly called as "Chuanwu" and "Fuzi" in China, respectively. A. carmichaelii is widely used for the treatment of cadianeuria, neuralgia, and rheumatalgia in Chinese medicine. According to the pharmacology studies, diterpenoid alkaloids accounted for the major effects and toxicity of this plant, such as hypaconitine, mesaconitine, aconitine...
May 21, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29785719/children-s-experiences-and-expectations-of-kidney-transplantation-a-qualitative-interview-study
#14
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29785670/polymorphic-imprinting-of-slc38a4-gene-in-bovine-placenta
#15
Da Xu, Cui Zhang, Junliang Li, Guannan Wang, Weina Chen, Dongjie Li, Shijie Li
Imprinted genes are characterized by monoallelic expression that is dependent on parental origin. Comparative analysis of imprinted genes between species is a powerful tool for understanding the biological significance of genomic imprinting. The slc38a4 gene encodes a neutral amino acid transporter and is identified as imprinted in mice. In this study, the imprinting status of SLC38A4 was assessed in bovine adult tissues and placenta using a polymorphism-based approach. Results indicate that SLC38A4 is not imprinted in eight adult bovine tissues including heart, liver, spleen, lung, kidney, muscle, fat, and brain...
May 21, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29785662/the-timing-and-circumstances-of-the-implementation-of-pediatric-palliative-care-in-hungarian-pediatric-oncology
#16
Judit Nyirő, Szilvia Zörgő, Földesi Enikő, Katalin Hegedűs, Péter Hauser
Despite the continuous improvement of pediatric palliative care, medical professionals still face various barriers regarding its implementation; our aim was to investigate this question in Hungarian pediatric oncology practice. Structured interviews were carried out in person with physicians from the Hungarian Pediatric Oncology Group (n = 22). Codes were generated inductively with the aid of Atlas.ti 6.0 software. Most physicians placed the palliative care discussion at the end of curative treatment (n = 21) and preferred to conduct it in a team setting (n = 18), mainly in the presence of a psychologist...
May 21, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29785651/genetic-analysis-of-the-human-insulin-like-3-gene-in-pediatric-patients-with-testicular-torsion
#17
Anna Paola Capra, Elisa Ferro, Maria Angela La Rosa, Silvana Briuglia, Tiziana Russo, Salvatore Arena, Carmelo Salpietro Damiano, Carmelo Romeo, Pietro Impellizzeri
PURPOSE: Testicular torsion (TT) mainly affects boys under 18 years old. To avoid orchiectomy, TT requires an immediate operative management. The etiology of TT is still controversial. Observed familiar recurrence suggests the presence of a genetic involvement. The INSL3 gene consists of two exons, and it is specifically expressed in fetal and adult Leydig cells. In transgenic mice, deletion of this gene was observed an increased testicular mobility and testicular torsion. We have hypothesized the possible involvement of the INSL3 gene as a predisposing factor of human TT...
May 21, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29785398/marker-assisted-introgression-of-saltol-qtl-enhances-seedling-stage-salt-tolerance-in-the-rice-variety-pusa-basmati-1
#18
Vivek Kumar Singh, Brahma Deo Singh, Amit Kumar, Sadhna Maurya, Subbaiyan Gopala Krishnan, Kunnummal Kurungara Vinod, Madan Pal Singh, Ranjith Kumar Ellur, Prolay Kumar Bhowmick, Ashok Kumar Singh
Marker-assisted selection is an unequivocal translational research tool for crop improvement in the genomics era. Pusa Basmati 1 (PB1) is an elite Indian Basmati rice cultivar sensitive to salinity. Here, we report enhanced seedling stage salt tolerance in improved PB1 genotypes developed through marker-assisted transfer of a major QTL, Saltol . A highly salt tolerant line, FL478, was used as the Saltol donor. Parental polymorphism survey using 456 microsatellite (SSR)/QTL-linked markers revealed 14.3% polymorphism between PB1 and FL478...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29785275/infant-activity-and-sleep-behaviors-in-a-maternal-and-infant-home-visiting-project-among-rural-southern-african-american-women
#19
Jessica L Thomson, Lisa M Tussing-Humphreys, Melissa H Goodman, Alicia S Landry
Background: Physical inactivity and inadequate amounts of sleep are two potential causes for excessive weight gain in infancy. Thus, parents and caregivers of infants need to be educated about decreasing infant sedentary behavior, increasing infant unrestrained floor time, as well as age specific recommended amounts of sleep for infants. The aims of this study were to determine if maternal knowledge about infant activity and sleep changed over time and to evaluate maternal compliance rates with expert recommendations for infant sleep in a two-arm, randomized, controlled, comparative impact trial...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29785201/speed-breeding-for-multiple-quantitative-traits-in-durum-wheat
#20
Samir Alahmad, Eric Dinglasan, Kung Ming Leung, Adnan Riaz, Nora Derbal, Kai P Voss-Fels, Jason A Able, Filippo M Bassi, Jack Christopher, Lee T Hickey
Background: Plant breeding requires numerous generations to be cycled and evaluated before an improved cultivar is released. This lengthy process is required to introduce and test multiple traits of interest. However, a technology for rapid generation advance named 'speed breeding' was successfully deployed in bread wheat ( Triticum aestivum L.) to achieve six generations per year while imposing phenotypic selection for foliar disease resistance and grain dormancy. Here, for the first time the deployment of this methodology is presented in durum wheat ( Triticum durum Desf...
2018: Plant Methods
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