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https://www.readbyqxmd.com/read/29782519/increased-circulating-microrna-122-is-a-biomarker-for-discrimination-and-risk-stratification-in-patients-defined-by-sepsis-3-criteria
#1
Tim Rahmel, Simon T Schäfer, Ulrich H Frey, Michael Adamzik, Jürgen Peters
BACKGROUND: Sepsis is now operationally defined as life-threatening organ dysfunction caused by an infection, identified by an acute change in SOFA-Score of at least two points, including clinical chemistry such as creatinine or bilirubin concentrations. However, little knowledge exists about organ-specific microRNAs as potentially new biomarkers. Accordingly, we tested the hypotheses that micro-RNA-122, the foremost liver-related micro-RNA (miR), 1) discriminates between sepsis and infection, 2) is an early predictor for mortality, and 3) improves the prognostic value of the SOFA-score...
2018: PloS One
https://www.readbyqxmd.com/read/29772836/soybean-hop-alleviates-estrogen-deficiency-related-bone-loss-and-metabolic-dysfunction-in-ovariectomized-rats-fed-a-high-fat-diet
#2
Dasom Noh, Yeni Lim, Hansol Lee, Hyejin Kim, Oran Kwon
Soybeans and hops have been traditionally used as a natural estrogen replacement therapy and their major active ingredients, isoflavones and prenylflavanones, are known to have estrogenic/antiestrogenic effects depending on the target organ. However, their potential benefits are still subject to controversies. The present study investigated the dual effect of soy isoflavones plus hop prenylflavanones (Soy-Hop) on bone loss and metabolic dysfunction under estrogen deficient condition. Rats were sham-operated ( n = 10) or ovariectomized (OVX; n = 40) and then fed a high-fat diet (HFD) to develop hyperlipidemia in OVX rats within the experimental period of 8 weeks...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29771925/in-vitro-and-in-vivo-biological-performance-of-porous-ti-alloys-prepared-by-powder-metallurgy
#3
Renata Falchete do Prado, Gabriela Campos Esteves, Evelyn Luzia De Souza Santos, Daiane Acácia Griti Bueno, Carlos Alberto Alves Cairo, Luis Gustavo Oliveira De Vasconcellos, Renata Silveira Sagnori, Fernanda Bastos Pereira Tessarin, Felipe Eduardo Oliveira, Luciane Dias De Oliveira, Maria Fernanda Lima Villaça-Carvalho, Vinicius André Rodrigues Henriques, Yasmin Rodarte Carvalho, Luana Marotta Reis De Vasconcellos
Titanium (Ti) and Ti-6 Aluminium-4 Vanadium alloys are the most common materials in implants composition but β type alloys are promising biomaterials because they present better mechanical properties. Besides the composition of biomaterial, many factors influence the performance of the biomaterial. For example, porous surface may modify the functional cellular response and accelerate osseointegration. This paper presents in vitro and in vivo evaluations of powder metallurgy-processed porous samples composed by different titanium alloys and pure Ti, aiming to show their potential for biomedical applications...
2018: PloS One
https://www.readbyqxmd.com/read/29771438/methylene-blue-attenuates-renal-ischemia-reperfusion-injury-by-negative-regulation-of-nlrp3-signaling-pathway
#4
J-J Liu, L Lu, F-Q Hu, H Yuan, Q Xu, Y-F Qin, J-H Gong
OBJECTIVE: To investigate the effect of methylene blue (MB) on renal ischemia-reperfusion (IR) injury in mice and its possible relevant mechanisms. MATERIALS AND METHODS: A total of 30 male C57/BL6 mice aged 4 months old were randomly divided into the following three groups: Sham group (n=10), IR group (n=10), and MB group (n=10). Mice in MB group were treated with gavage continuously using methylene blue solution (dosage: 25 mg·kg-1·d-1) until they were 7 months old...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771401/mir-133a-inhibits-fracture-healing-via-targeting-runx2-bmp2
#5
H Peng, S-L Lu, Y Bai, X Fang, H Huang, X-Q Zhuang
OBJECTIVE: To analyze the mechanism of miR-133a in inhibiting fracture healing through regulating runt-related transcription factor 2 (RUNX2) signaling pathway. PATIENTS AND METHODS: A total of 80 patients with fracture admitted to our hospital from January 2016 to January 2017 were divided into 2 groups according to nonunion fracture or healing fracture: nonunion fracture group (n = 40) and control group (n= 40). After admission, patients underwent the surgery, respectively, and the bone tissues were taken for stand-by application...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29764543/-experimental-research-on-individual-specific-rapid-potassium-supplementation-strategy-for-fatal-severe-hypokalemia
#6
Yu Du, Yi Mou, Jin Liu
OBJECTIVE: To explore the effectiveness and safety of the individual-specific rapid potassium supplementation strategy, and to provide experimental basis for treating fatal severe hypokalemia. METHODS: An acute fatal severe hypokalemia model was reproduced in 20 healthy adult Japanese big ear white rabbits with half lethal dose (LD50) of barium chloride (BaCl2 ) solution 168 mg×5 mL-1 ×kg-1 . The rabbits were divided into conventional potassium supplementation group and individual-specific rapid potassium supplementation group according to random number table method with 10 rabbits in each group...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29754982/computed-tomography-techniques-help-understand-wear-patterns-in-retrieved-total-knee-arthroplasty
#7
Arianna Cerquiglini, Johann Henckel, Harry S Hothi, Lorenzo Dall'Ava, Paul Shearing, Michael T Hirschmann, Alister J Hart
BACKGROUND: Suboptimal total knee arthroplasty (TKA) position of both femoral and tibial components is thought to be linked with poor clinical outcomes, polyethylene wear and the "unexplained" painful knee arthroplasty. The aim of this study was to better understand the effect of implant orientation on knee implant performance. METHODS: We analyzed 30 retrieved contemporary TKA implants. Implant positioning measurements in the coronal plane were made prior to revision using a diagnostic algorithm, based on 3D computed tomography (CT) images...
April 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29749513/bioinformatics-analysis-of-key-differentially-expressed-genes-in-well-and-poorly-differentiated-endometrial-carcinoma
#8
Yuqin Zang, Mengting Dong, Kai Zhang, Wenyan Tian, Yingmei Wang, Fengxia Xue
Endometrial carcinoma (EC) is one of the most common gynecological malignancies. The malignant degree increases between grade (G)1 and G3, and EC of G3 usually presents a high recurrence rate and poor prognosis. Therefore, the present study aimed to examine the principal genes associated with the degree of differentiation in EC. The microarrays GSE17025, GSE24537 and GSE35784, representing data of Type I EC samples of G1 and G3, were downloaded from the Gene Expression Omnibus. The differentially expressed genes (DEGs) and differentially expressed micro (mi)RNAs (DEMs) were identified, followed by functional enrichment analyses and interaction network construction...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748497/profiling-of-phenolic-compounds-and-antioxidant-activity-of-12-cruciferous-vegetables
#9
Zhifeng Li, Hui Wen Lee, Xu Liang, Dong Liang, Qi Wang, Dejian Huang, Choon Nam Ong
The phenolic profiles of 12 cruciferous vegetables (pakchoi, choysum, Chinese cabbage, kailan, Brussels sprout, cabbage, cauliflower, broccoli, rocket salad, red cherry radish, daikon radish, and watercress) were studied with UHPLC-MS/MS. Antioxidant activity and total phenolic content (TPC) were also evaluated. A total of 74 phenolic compounds were identified, including 16 hydroxycinnamic acids and derivatives, and 58 flavonoids and derivatives. The main flavonoids identified were glycosylated quercetin, kaempferol and isorhamnetin, and the main hydroxycinnamic acids were ferulic, sinapic, caffeic and p -coumaric acids...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29747446/evaluation-of-the-impact-of-storage-conditions-on-the-biogenic-amines-profile-in-opened-wine-bottles
#10
Justyna Płotka-Wasylka, Vasil Simeonov, Jacek Namieśnik
A survey of biogenic amine (BA) profiles in opened wine bottles has been established to monitor the level of biogenic amines (BAs) in opened bottles against time and other conditions. Bottles of red and white wine were submitted to different temperatures, stopper type (screw cap, cork), and use of vacuum devices. A total of six wines made from a variety of grapes were obtained from vineyards from regions across Poland. Dispersive liquid-liquid microextraction-gas chromatography-mass spectrometry (DLLME-GC-MS) procedure for BAs determination was validated and applied for wine sample analysis...
May 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29744723/micro-ct-evaluation-of-different-final-irrigation-protocols-on-the-removal-of-hard-tissue-debris-from-isthmus-containing-mesial-root-of-mandibular-molars
#11
Emmanuel João Nogueira Leal Silva, Carla Rodrigues Carvalho, Felipe Gonçalves Belladonna, Marina Carvalho Prado, Ricardo Tadeu Lopes, Gustavo De-Deus, Edson Jorge Lima Moreira
OBJECTIVES: This study aimed to compare four final irrigation protocols (passive ultrasonic irrigation [PUI], EndoVac, Self-Adjusting File [SAF] and EasyClean) on the removal of accumulated hard-tissue debris (AHTD) from mesial canals of mandibular molars through microcomputed tomographic (micro-CT) analysis. MATERIALS AND METHODS: Forty mesial roots of mandibular molars presenting isthmuses type I or III were scanned in a micro-CT device and instrumented up to Reciproc R40 instrument...
May 10, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29742257/a-serm-increasing-the-expression-of-the-osteoblastogenesis-and-mineralization-related-proteins-and-improving-quality-of-bone-tissue-in-an-experimental-model-of-osteoporosis
#12
Fernanda Costa Yogui, Gustavo Antonio Correa Momesso, Leonardo Perez Faverani, Tarik Ocon Braga Polo, Gabriel Ramalho-Ferreira, Jaqueline Suemi Hassumi, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Felippe Bevilacqua Prado, Roberta Okamoto
Raloxifene is an antiresorptive drug, selective estrogen receptor modulator (SERM) used in the treatment of osteoporosis. Objective To evaluate proteins related to bone repair at the peri-implant bone in a rat model of osteoporosis treated with raloxifene. Material and Methods 72 rats were divided into three groups: SHAM (healthy animals), OVX (ovariectomized animals), and RLX (ovariectomized animals treated with raloxifene). Raloxifene was administered by gavage (1 mg/kg/day). Tibial implantation was performed 30 days after ovariectomy, and animals were euthanized at 14, 42, and 60 days postoperatively...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29738265/estimation-and-prediction-of-avoidable-health-care-costs-of-cardiovascular-diseases-and-type-2-diabetes-through-adequate-dairy-food-consumption-a-systematic-review-and-micro-simulation-modeling-study
#13
Mehdi Javanbakht, Ahmad Reza Jamshidi, Hamid Reza Baradaran, Zahra Mohammadi, Atefeh Mashayekhi, Farhad Shokraneh, Mohsen Rezai Hamami, Raziyeh Yazdani Bakhsh, Hossien Shabaninejad, Sajad Delavari, Arash Tehrani
BACKGROUND: Recent evidence from prospective cohort studies show a relationship between consumption of dairy foods and cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). This association highlights the importance of dairy foods consumption in prevention of these diseases and also reduction of associated healthcare costs. The aim of this study was to estimate avoidable healthcare costs of CVD and T2D through adequate dairy foods consumption in Iran. METHODS: This was a multistage modelling study...
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29737292/analysis-of-curative-effect-of-fluoxetine-and-escitalopram-in-the-depression-treatment-based-on-clinical-observation
#14
Zhang Xiaoling, Han Yunping, Lian Yingdong
Depression is a common affective disorder or mood disorder, which seriously affects people's physical and mental health and the quality of life. This study compared efficacy of escitalopram and fluoxetine on depression patients, and analyzed the inflammatory factors, serum homocysteine (Hcy) levels and the effects of adverse reactions, so as to provide reference for the clinical. The results showed that the total effective rate of the observation group (90.7%) was higher than that of the control group (80%), but the difference was not statistically significant (p>0...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735074/study-of-the-aroma-formation-and-transformation-during-the-manufacturing-process-of-oolong-tea-by-solid-phase-micro-extraction-and-gas-chromatography-mass-spectrometry-combined-with-chemometrics
#15
Chengying Ma, Junxing Li, Wei Chen, Wenwen Wang, Dandan Qi, Shi Pang, Aiqing Miao
Oolong tea is a typical semi-fermented tea and is famous for its unique aroma. The aim of this study was to compare the volatile compounds during manufacturing process to reveal the formation of aroma. In this paper, a method was developed based on head-space solid phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS) combined with chemometrics to assess volatile profiles during manufacturing process (fresh leaves, sun-withered leaves, rocked leaves and leaves after de-enzyming). A total of 24 aroma compounds showing significant differences during manufacturing process were identified...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29730258/a-combination-of-interdisciplinary-analytical-tools-for-evaluation-of-multi-layered-coatings-on-medical-grade-stainless-steel-for-biomedical-applications
#16
Uroš Maver, Klodian Xhanari, Marko Žižek, Dorota Korte, Lidija Gradišnik, Mladen Franko, Matjaž Finšgar
In this comprehensive study several analytical techniques were used in order to evaluate multi--layered biomedical surface coatings composed of a drug (diclofenac) and a polymer (chitosan). Such a thorough examination is of paramount importance in order to assure safety and prove efficiency of potential biomedical materials already at the in vitro level, hence leading to their potentially faster introduction to clinical trials. For the first time a novel technique based on thermal diffusivity and conductivity measurement (photothermal beam deflection spectroscopy - BDS) was employed in order to analyse in a non-destructive way the thickness of respective layers, together with their thermal diffusivity and conductivity...
May 3, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29726494/what-is-a-troland
#17
Larry N Thibos, Norberto Lopez-Gil, Arthur Bradley
Trolands are a widely used measure of retinal illuminance in vision science and visual optics, but disagreements exist for the definition and interpretation of this photometric unit. The purpose of this communication is to resolve the confusion by providing a sound conceptual basis for interpreting trolands as a measure of angular flux density incident upon the retina. Using a simplified optical analysis, we show that the troland value of an extended source is the intensity in micro-candelas of an equivalent point source located at the eye's posterior nodal point that produces the same illuminance in the retinal image as does the extended source...
May 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29721224/porosity-analysis-of-mta-and-biodentine-cements-for-use-in-endodontics-by-using-micro-computed-tomography
#18
Fabricio Guerrero, Esther Berástegui
Background: The purpose of this study is to compare the porosity of two repair cements, White ProRoot® MTA and Biodentine®. These samples were analyzed by using micro-computed microtomography. Material and Methods: Sixteen samples were used in the study that were divided according to the composition of the materials used. White ProRoot® MTA (n = 8) and Biodentine® (n = 8) were the samples prepared according to the manufacturer's instructions. They were placed in silicone molds of 5 ± 0...
March 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29712526/the-estimated-cost-of-surgically-managed-isolated-traumatic-head-injury-secondary-to-road-traffic-accidents
#19
Xinli You, Boon S Liew, Azmin K Rosman, Dcsn, Kamarul Imran Musa, Zamzuri Idris
OBJECTIVE Traumatic brain injury due to road traffic accidents occurs mainly in the younger age group in which injury-related disability leads to long-term impact on employment and economic and social consequences across the lifespan. This study was designed to assign a monetary cost (in Malaysian ringgits [RM]) to the treatment of patients with surgically treated isolated traumatic head injury as determined up to 1 year after injury. METHODS Relevant resource items used were identified and valued using the direct measurement of costs method, cost accounting methods, standard unit costs method, fees, charges and/or market prices method...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29710769/the-food-specific-serum-igg-reactivity-in-major-depressive-disorder-patients-irritable-bowel-syndrome-patients-and-healthy-controls
#20
Hanna Karakula-Juchnowicz, Mirosława Gałęcka, Joanna Rog, Anna Bartnicka, Zuzanna Łukaszewicz, Pawel Krukow, Justyna Morylowska-Topolska, Karolina Skonieczna-Zydecka, Tomasz Krajka, Kamil Jonak, Dariusz Juchnowicz
There is an increasing amount of evidence which links the pathogenesis of irritable bowel syndrome (IBS) with food IgG hyperreactivity. Some authors have suggested that food IgG hyperreactivity could be also involved in the pathophysiology of major depressive disorder (MDD). The aim of this study was to compare levels of serum IgG against 39 selected food antigens between three groups of participants: patients with MDD (MDD group), patients with IBS (IBS group) and healthy controls (HC group). The study included 65 participants (22 in the MDD group, 22 in the IBS group and 21 in the HC group)...
April 28, 2018: Nutrients
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