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https://www.readbyqxmd.com/read/29145714/clinical-and-biochemical-correlates-of-male-hypogonadism-in-type-2-diabetes
#1
A Herrero, M Marcos, P Galindo, J M Miralles, J J Corrales
The origin of hypogonadism, a condition including both symptoms and biochemical criteria of androgen deficiency, in type 2 diabetes is poorly known. In a cross-sectional study of 267 unselected patients, we analyzed the potential correlation of several clinical and biochemical variables as well as chronic micro- and macrovascular diabetic complications with hypogonadism. Hypogonadism was present in 46 patients (17.2%) using a cutoff of total testosterone 10.4 nmol/L and in 31 (11.6%) with a cutoff of 8 nmol/L...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29134721/atr-ftir-spectroscopy-and-%C3%AE-edxrf-spectrometry-monitoring-of-enamel-erosion-caused-by-medicaments-used-in-the-treatment-of-respiratory-diseases
#2
Raimundo Nonato Silva Gomes, Tanmoy T Bhattacharjee, Luis Felipe C S Carvalho, Luís Eduardo Silva Soares
Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro-energy-dispersive X-ray fluorescence spectrometry (µ-EDXRF) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR)...
November 14, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29134132/abnormal-subchondral-bone-remodeling-and-its-association-with-articular-cartilage-degradation-in-knees-of-type-2-diabetes-patients
#3
Yan Chen, Yong-Can Huang, Chun Hoi Yan, Kwong Yuen Chiu, Qingjun Wei, Jingmin Zhao, X Edward Guo, Frankie Leung, William W Lu
Type 2 diabetes (T2D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile, abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis (OA). Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic (n=70) and diabetes (n=51) groups...
2017: Bone Research
https://www.readbyqxmd.com/read/29134065/a-bird-like-skull-in-a-triassic-diapsid-reptile-increases-heterogeneity-of-the-morphological-and-phylogenetic-radiation-of-diapsida
#4
Adam C Pritchard, Sterling J Nesbitt
The Triassic Period saw the first appearance of numerous amniote lineages (e.g. Lepidosauria, Archosauria, Mammalia) that defined Mesozoic ecosystems following the end Permian Mass Extinction, as well as the first major morphological diversification of crown-group reptiles. Unfortunately, much of our understanding of this event comes from the record of large-bodied reptiles (total body length > 1 m). Here we present a new species of drepanosaurid (small-bodied, chameleon-like diapsids) from the Upper Triassic Chinle Formation of New Mexico...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29132358/ftir-spectroscopy-as-a-unified-method-for-simultaneous-analysis-of-intra-and-extracellular-metabolites-in-high-throughput-screening-of-microbial-bioprocesses
#5
Gergely Kosa, Volha Shapaval, Achim Kohler, Boris Zimmermann
BACKGROUND: Analyses of substrate and metabolites are often bottleneck activities in high-throughput screening of microbial bioprocesses. We have assessed Fourier transform infrared spectroscopy (FTIR), in combination with high throughput micro-bioreactors and multivariate statistical analyses, for analysis of metabolites in high-throughput screening of microbial bioprocesses. In our previous study, we have demonstrated that high-throughput (HTS) FTIR can be used for estimating content and composition of intracellular metabolites, namely triglyceride accumulation in oleaginous filamentous fungi...
November 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29131249/study-on-the-expression-and-mechanism-of-plasma-microrna-21-in-patients-with-ischemic-cardiomyopathy
#6
M-B Xie, X-Q Sui, D Pei, Q Yao, Q Huang
OBJECTIVE: To investigate the expression and mechanism of plasma microRNA-21 in patients with ischemic cardiomyopathy (ICM). PATIENTS AND METHODS: 56 cases of ICM patients were selected in our hospital from February 2010 to March 2016 as the observation group, and 60 cases of healthy patients were selected as control group. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression of microRNA-21 in two groups. Then, differences of the total cholesterol (TC), triglycerides (TG), left ventricular ejection fraction (LVEF), high and low density lipoprotein cholesterol (HDL-C, LDL-C), left ventricular end-diastolic volume (LVEDV), N terminal B type brain natriuretic peptide (NT-proBNP) and other clinical indicators of the two groups, were compared...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29129053/research-on-chemical-composition-and-biological-properties-including-anti-quorum-sensing-activity-of-angelica-pancicii-vandas-aerial-parts-and-roots
#7
Ksenija S Mileski, Snežana S Trifunović, Ana D Ćirić, Željana M Šakić, Mihailo S Ristić, Nina M Todorović, Vlado S Matevski, Petar D Marin, Vele V Tesevic, Ana M Džamić
The essential oil, different extracts and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%) and β-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicated coumarins as the main constituents...
November 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29121074/proteome-profiling-in-the-aorta-and-kidney-of-type-1-diabetic-rats
#8
Moustafa Al Hariri, Mohamad Elmedawar, Rui Zhu, Miran A Jaffa, Jingfu Zhao, Parvin Mirzaei, Adnan Ahmed, Firas Kobeissy, Fuad N Ziyadeh, Yehia Mechref, Ayad A Jaffa
Diabetes is associated with a number of metabolic and cardiovascular risk factors that contribute to a high rate of microvascular and macrovascular complications. The risk factors and mechanisms that contribute to the development of micro- and macrovascular disease in diabetes are not fully explained. In this study, we employed mass spectrometric analysis using tandem LC-MS/MS to generate a proteomic profile of protein abundance and post-translational modifications (PTM) in the aorta and kidney of diabetic rats...
2017: PloS One
https://www.readbyqxmd.com/read/29118579/surface-modification-of-vascular-endothelial-growth-factor-loaded-silk-fibroin-to-improve-biological-performance-of-ultra-high-molecular-weight-polyethylene-via-promoting-angiogenesis
#9
Chengchong Ai, Dandan Sheng, Jun Chen, Jiangyu Cai, Siheng Wang, Jia Jiang, Shiyi Chen
Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone-implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29115493/mir-92a-regulates-the-expression-levels-of-matrix-metalloproteinase-9-and-tissue-inhibitor-of-metalloproteinase-3-via-sirtuin-1-signaling-in-hydrogen-peroxide-induced-vascular-smooth-muscle-cells
#10
Peng Liu, Jianfang Su, Xixi Song, Shixiao Wang
Vascular smooth muscle cells (VSMCs) exhibit a notably increased rate of migration, which is one of the most common pathological changes in atherosclerosis. Investigations into the role of micro (mi)RNAs in the regulation of VSMC migration are beginning to emerge and additional miRNAs involved in VSMC migration modulation require identification. In the current study, VSMCs were primarily cultured from rat thoracic aortas, transfected with miR‑92a mimics and induced by hydrogen peroxide (H2O2) for 24 h. Total mRNA and protein were collected for quantitative polymerase chain reaction and western blot analysis...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29109452/a-digital-microfluidic-system-for-loop-mediated-isothermal-amplification-and-sequence-specific-pathogen-detection
#11
Liang Wan, Tianlan Chen, Jie Gao, Cheng Dong, Ada Hang-Heng Wong, Yanwei Jia, Pui-In Mak, Chu-Xia Deng, Rui P Martins
A digital microfluidic (DMF) system has been developed for loop-mediated isothermal amplification (LAMP)-based pathogen nucleic acid detection using specific low melting temperature (Tm) Molecular Beacon DNA probes. A positive-temperature-coefficient heater with a temperature sensor for real-time thermal regulation was integrated into the control unit, which generated actuation signals for droplet manipulation. To enhance the specificity of the LAMP reaction, low-Tm Molecular Beacon probes were designed within the single-stranded loop structures on the LAMP reaction products...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109097/role-of-melt-curve-analysis-in-interpretation-of-nutrigenomics-microrna-expression-data
#12
Farid E Ahmed, Mostafa M Gouda, Laila A Hussein, Nancy C Ahmed, Paul W Vos, Mahmoud A Mohammad
This article illustrates the importance of melt curve analysis (MCA) in interpretation of mild nutrogenomic micro(mi)RNA expression data, by measuring the magnitude of the expression of key miRNA molecules in stool of healthy human adults as molecular markers, following the intake of Pomegranate juice (PGJ), functional fermented sobya (FS), rich in potential probiotic lactobacilli, or their combination. Total small RNA was isolated from stool of 25 volunteers before and following a three-week dietary intervention trial...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29107418/evaluation-of-microplastic-release-caused-by-textile-washing-processes-of-synthetic-fabrics
#13
Francesca De Falco, Maria Pia Gullo, Gennaro Gentile, Emilia Di Pace, Mariacristina Cocca, Laura Gelabert, Marolda Brouta-Agnésa, Angels Rovira, Rosa Escudero, Raquel Villalba, Raffaella Mossotti, Alessio Montarsolo, Sara Gavignano, Claudio Tonin, Maurizio Avella
A new and more alarming source of marine contamination has been recently identified in micro and nanosized plastic fragments. Microplastics are difficult to see with the naked eye and to biodegrade in marine environment, representing a problem since they can be ingested by plankton or other marine organisms, potentially entering the food web. An important source of microplastics appears to be through sewage contaminated by synthetic fibres from washing clothes. Since this phenomenon still lacks of a comprehensive analysis, the objective of this contribution was to investigate the role of washing processes of synthetic textiles on microplastic release...
October 26, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29104492/pth-1-34-ameliorates-the-osteopenia-and-delayed-healing-of-stabilized-tibia-fracture-in-mice-with-achondroplasia-resulting-from-gain-of-function-mutation-of-fgfr3
#14
Hangang Chen, Xianding Sun, Liangjun Yin, Shuai Chen, Ying Zhu, Junlan Huang, Wanling Jiang, Bo Chen, Ruobin Zhang, Lin Chen, Mao Nie, Yangli Xie, Zhongliang Deng
Bone fracture healing is processed through multiple stages including the cartilaginous callus formation and its transition to bony callus. FGFR3 negatively regulates chondrogenesis and enhances osteogenesis during skeleton development. We previously found in mice carrying gain-of-function mutation of FGFR3 that FGFR3 delays the healing of un-stabilized fracture that heals mainly through endochondral ossification. Since fracture is regularly treated in clinics with rigid fixation, and stabilized fracture is healed largely through intramembranous ossification, we asked whether FGFR3, a key regulator of osteogenesis, also affect the regeneration of stabilized fracture...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29104265/design-and-electro-thermo-mechanical-behavior-analysis-of-au-si%C3%A2-n%C3%A2-bimorph-microcantilevers-for-static-mode-sensing
#15
Seok-Won Kang, Joe Fragala, Su-Ho Kim, Debjyoti Banerjee
This paper presents a design optimization method based on theoretical analysis and numerical calculations, using a commercial multi-physics solver (e.g., ANSYS and ESI CFD-ACE+), for a 3D continuous model, to analyze the bending characteristics of an electrically heated bimorph microcantilever. The results from the theoretical calculation and numerical analysis are compared with those measured using a CCD camera and magnification lenses for a chip level microcantilever array fabricated in this study. The bimorph microcantilevers are thermally actuated by joule heating generated by a 0...
November 1, 2017: Sensors
https://www.readbyqxmd.com/read/29098563/melanization-affects-the-content-of-selected-elements-in-parmelioid-lichens
#16
Lorenzo Fortuna, Elena Baracchini, Gianpiero Adami, Mauro Tretiach
Lichens belonging to Parmeliaceae are highly diversified, but most of them share an extremely conserved morpho-chemical trait: the lower cortex is heavily melanized. The adaptive value of this character is still uncertain. Melanins are ubiquitous compounds found in most organisms since they fulfil several biological functions including defense against UV radiation, oxidizing agents, microbial stress, and metal complexation. This work aims to establish whether melanization can affect the elemental content of lichen thalli...
November 3, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29096602/identification-and-expression-profiling-of-micrornas-involved-in-the-stigma-exsertion-under-high-temperature-stress-in-tomato
#17
Changtian Pan, Lei Ye, Yi Zheng, Yan Wang, Dandan Yang, Xue Liu, Lifei Chen, Youwei Zhang, Zhangjun Fei, Gang Lu
BACKGROUND: Autogamy in cultivated tomato varieties is a derived trait from wild type tomato plants, which are mostly allogamous. However, environmental stresses can cause morphological defects in tomato flowers and hinder autogamy. Under elevated temperatures, tomato plants usually exhibit the phenotype of stigma exsertion, with severely hindered self-pollination and fruit setting, whereas the inherent mechanism of stigma exsertion have been hitherto unknown. Numerous small RNAs (sRNAs) have been shown to play significant roles in plant development and stress responses, however, none of them have been studied with respect to stamen and pistil development under high-temperature conditions...
November 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29093234/comparative-cost-analysis-of-four-interventions-to-prevent-hiv-transmission-in-bandung-indonesia
#18
Eveline J M Verstraaten, Fenna M M Beeren, Jip L C Janssen, Sophie Kemper, Adiatma Y M Siregar, Noor Tromp, Rob Baltussen
BACKGROUND: the costs of HIV/AIDS interventions in Indonesia are largely unknown. Knowing these costs is an important input for policy makers in the decision-making of setting priorities among HIV/AIDS interventions. The aim of this analysis is to determine the costs of four HIV/AIDS interventions in Bandung, Indonesia in 2015, to inform the local AIDS commission. METHODS: data on utilization and costs of the different interventions were collected in a sexual transmitted infections (STI)-clinic and the KPA, the local HIV/AIDS commission, for the period of January 2015-December 2015...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29091962/porcine-brain-extract-promotes-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-and-bone-consolidation-in-a-rat-distraction-osteogenesis-model
#19
Jia Xu, Yuxin Sun, Tianyi Wu, Bin Wang, Yang Liu, Jinfang Zhang, Wayne Yukwai Lee, Qinglin Kang, Yimin Chai, Gang Li
Distraction osteogenesis (DO) is the gold standard to treat large bone defects, but long consolidation period is a major limitation. Innovative efforts to promote osteogenesis are needed. Porcine brain extract (PBE) was reported to enhance the proliferation and differentiation of multiple primary cells. In this study, we aimed to develop a method for collecting PBE and investigate its effects on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells (rBMSCs) and bone consolidation in a rat DO model...
2017: PloS One
https://www.readbyqxmd.com/read/29080210/cost-effectiveness-of-exenatide-once-weekly-versus-insulin-glargine-and-liraglutide-for-the-treatment-of-type-2-diabetes-mellitus-in-greece
#20
Charalampos Tzanetakos, Alexandra Bargiota, Georgia Kourlaba, George Gourzoulidis, Nikos Maniadakis
OBJECTIVE: The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients with type 2 diabetes mellitus (T2DM) not adequately controlled on oral antidiabetic drug (OAD) therapy in Greece. METHODS: The published and validated Cardiff Diabetes Model was used to project clinical and economic outcomes over a patient's lifetime...
October 27, 2017: Clinical Drug Investigation
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