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https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#1
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29677199/implications-of-current-therapeutic-restrictions-for-primaquine-and-tafenoquine-in-the-radical-cure-of-vivax-malaria
#2
James Watson, Walter R J Taylor, Germana Bancone, Cindy S Chu, Podjanee Jittamala, Nicholas J White
BACKGROUND: The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women. METHODS: Quantitative G6PD enzyme activity data from 5198 individuals were used to estimate the proportions of heterozygous females who would be ineligible for treatment at the 30% and 70% activity thresholds, and the relationship with the severity of the deficiency...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29674313/key-lessons-and-impact-of-the-growing-healthy-mhealth-program-on-milk-feeding-timing-of-introduction-of-solids-and-infant-growth-quasi-experimental-study
#3
Rachel A Laws, Elizabeth A Denney-Wilson, Sarah Taki, Catherine G Russell, Miaobing Zheng, Eloise-Kate Litterbach, Kok-Leong Ong, Sharyn J Lymer, Rosalind Elliott, Karen J Campbell
BACKGROUND: The first year of life is an important window to initiate healthy infant feeding practices to promote healthy growth. Interventions delivered by mobile phone (mHealth) provide a novel approach for reaching parents; however, little is known about the effectiveness of mHealth for child obesity prevention. OBJECTIVE: The objective of this study was to determine the feasibility and effectiveness of an mHealth obesity prevention intervention in terms of reach, acceptability, and impact on key infant feeding outcomes...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29669265/modification-of-ige-binding-to-%C3%AE-s1-casein-by-proteolytic-activity-of-enterococcus-faecium-isolated-from-iranian-camel-milk-samples
#4
Reihane Kordesedehi, Asghar Taheri-Kafrani, Mohammad Rabbani-Khorasgani, Rezvan Kazemi, Daniel Mutangadura, Thomas Haertle
Milk is a perfect source of nutrients for neonates. When breast feeding cannot be done, an infant's alimentation is usually initiated to cow's milk, among the primary foods. It has been reported that about 2.5% of juveniles under the age of 3 years manifest allergic reactions to cow's milk proteins. Among the cow's milk proteins, casein fractions are considered as the strongest allergenic proteins. The proteolytic enzymes of lactic acid bacteria (LAB), during fermentation of dairy products, can break down milk proteins especially caseins and subsequently reduce the immune reactivity of allergenic proteins...
April 15, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29664501/good-health-indicators-in-children-with-down-syndrome-high-frequency-of-exclusive-breastfeeding-at-6-months
#5
Lorena Génova, Jaime Cerda, Catalina Correa, Natalia Vergara, Macarena Lizama
AIM: To describe the frequency of exclusive breastfeeding at 6 months in binomial of mother and in fants with Down Syndrome (DS) attending at the Health net UC CHRISTUS (PSSPSD-UC), and iden tify the main factors associated with exclusive breastfeeding cessation. PATIENTS AND METHODS: Prevalence study of exclusively breastfeeding at 6 months of age that includes mother-child binomial of Chilean infants with (DS) aged 6-24 months, who attend the PSSPSD-UC. An on-line questionnaire was conducted, which included demographic data, child's background and experience in breastfee ding...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29650183/the-combination-of-nebulization-and-chest-physiotherapy-improved-respiratory-status-in-children-with-pneumonia
#6
Nur Eni Lestari, Nani Nurhaeni, Siti Chodidjah
OBJECTIVE: There is controversy regarding the effectiveness of chest physiotherapy to solve airway obstruction problems experienced by children younger than five years of age with pneumonia. The aim of this study was to determine the effectiveness of chest physiotherapy and nebulization on the respiratory status of these children. METHOD: This study was quasi-experimental with a pre- and post-test nonequivalent control group design. Thirty-four respondents selected by consecutive sampling were divided into two groups: one that received nebulization and one that received nebulization with chest physiotherapy...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29643909/hyperlipidemia-and-hyper-glycaemia-in-breast-cancer-patients-is-related-to-disease-stage
#7
Uzma Raza, Mahay Rookh Asif, Asif Bin Rehman, Aminuddin Sheikh
Objective: The study was designed to determine the hyperlipidemia in breast cancer of patients at disease presentation, without any treatment and to correlate these variations with disease stage. Methods: This cross sectional study was conducted at Liaquat National teaching hospital in Karachi from 2006 to 2011, Age and family history of 208 breast cancer patients with infiltrating Ductal Carcinoma were compared with 176 matched control subjects. Married females were selected, with children and short breast feeding period...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29626043/hiv-1-disease-progression-in-immune-competent-hiv-1-infected-and-breastfeeding-mothers-participating-in-the-anrs-12174-clinical-trial-in-burkina-faso-south-africa-uganda-and-zambia-a-cohort-study
#8
Eric Nagaonle Somé, Ingunn M S Engebretsen, Nicolas Nagot, Nicolas Yelbomkan Meda, Roselyne Vallo, Chipepo Kankasa, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, G Justus Hofmeyr, Philippe Van de Perre, Thorkild Tylleskär
OBJECTIVE: We have assessed HIV-1 disease progression among HIV-1-positive mothers in relation to duration of any or exclusive breast feeding in the context of ANRS 12174 trial. METHODS: The analysis was completed on 203, 212, 272 and 529 HIV-1-positive and lactating mothers with CD4 count >350 cells/µL from Burkina Faso, South Africa, Uganda and Zambia, respectively. The trial compared lamivudine and lopinavir/ritonavir as a peri-exposure prophylaxis during a 50-week follow-up time...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625509/adult-congenital-heart-disease-with-pregnancy
#9
REVIEW
Koichiro Niwa
The number of women with congenital heart disease (CHD) at risk of pregnancy is growing because over 90% of them are grown-up into adulthood. The outcome of pregnancy and delivery is favorable in most of them provided that functional class and systemic ventricular function are good. Women with CHD such as pulmonary hypertension (Eisenmenger syndrome), severe left ventricular outflow stenosis, cyanotic CHD, aortopathy, Fontan procedure and systemic right ventricle (complete transposition of the great arteries [TGA] after atrial switch, congenitally corrected TGA) carry a high-risk...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29622907/sub-optimal-breastfeeding-and-its-associated-factors-in-rural-communities-of-hula-district-southern-ethiopia-a-cross-sectional-study
#10
Shibru Hoche, Berhan Meshesha, Negash Wakgari
Background: Sub-optimal breast feeding contributed a significant number of infants' death. Although breast feeding is universal in Ethiopia, the practice is not optimal. Hence, this study assessed the prevalence of sub-optimal breast feeding practice and its associated factors in rural communities of Hula District, Southern Ethiopia. Methods: A community based cross-sectional study was conducted among 634 women with infants aged 6 to 12 months. Multistage sampling technique was employed to select study subjects...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29622825/gastrointestinal-food-allergy-in-ghanaian-children-a-case-series
#11
Taiba J Afaa, Adwoa Ka Afrane, Victor Etwire
Background: Food allergy is an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food allergies are classified into three types: Ig(immunoglobulin)E mediated, mixed IgE and cell mediated and cell-mediated non IgE mediated. Gastrointestinal (GIT) food allergy has classically encompassed a number of different clinical entities: food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP), food protein-induced enteropathy and eosinophilic gastrointestinal disorders (EGID)...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29617676/glycosylation-of-human-iga-directly-inhibits-influenza-a-and-other-sialic-acid-binding-viruses
#12
Michael A Maurer, Larissa Meyer, Matteo Bianchi, Hannah L Turner, Ngoc P L Le, Marco Steck, Arkadiusz Wyrzucki, Vanessa Orlowski, Andrew B Ward, Max Crispin, Lars Hangartner
Immunoglobulin A (IgA) plays an important role in protecting our mucosal surfaces from viral infection, in maintaining a balance with the commensal bacterial flora, and in extending maternal immunity via breast feeding. Here, we report an additional innate immune effector function of human IgA molecules in that we demonstrate that the C-terminal tail unique to IgA molecules interferes with cell-surface attachment of influenza A and other enveloped viruses that use sialic acid as a receptor. This antiviral activity is mediated by sialic acid found in the complex N-linked glycans at position 459...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29617367/gene-set-analysis-of-post-lactational-mammary-gland-involution-gene-signatures-in-inflammatory-and-triple-negative-breast-cancer
#13
Arvind Bambhroliya, Renae D Van Wyhe, Swaminathan Kumar, Bisrat G Debeb, Jay P Reddy, Steve Van Laere, Randa El-Zein, Arvind Rao, Wendy A Woodward
BACKGROUND: Epidemiological studies have found that triple-negative breast cancer (TNBC) and TN inflammatory breast cancer (IBC) are associated with lower frequency and duration of breast-feeding compared to non-TNBC and non-TN IBC, respectively. Limited breast-feeding could reflect abrupt or premature involution and contribute to a "primed" stroma that is permissive to the migration of cancer cells typical of IBC. We hypothesized that gene expression related to abrupt mammary gland involution after forced weaning may be enriched in the tissues of IBC patients and, if so, provide a potential correlation between limited breast-feeding and the development of aggressive breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29611127/the-levels-of-polycyclic-aromatic-hydrocarbons-pahs-in-human-milk-and-exposure-risk-to-breastfed-infants-in-petrochemical-industrialized-lanzhou-valley-northwest-china
#14
Li Wang, Aiping Liu, Yuan Zhao, Xi Mu, Tao Huang, Hong Gao, Jianmin Ma
We investigated in this paper the presence of PAHs in human milk from lactating women residing in Lanzhou, a petrochemical industrialized valley city in Northwest China. The PAH concentration levels in human milk samples from 98 healthy women were determined by gas chromatography/mass spectrometry (GC/MS). The associations between the lifestyle factors and the PAHs levels of human milk were analyzed. Moreover, we applied principal component analysis (PCA) method to gain a better insight into the similarities or dissimilarities of the human milk PAH loads and different pathways of source exposure...
April 3, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29609490/colostrum-and-mature-breast-milk-analysis-of-serum-irisin-and-sterol-regulatory-element-binding-proteins-1c-in-gestational-diabetes-mellitus
#15
Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali
BACKGROUND: We aimed to evaluate irisin and SREBP-1c levels in serum, colostrum and mature breast milk in women with and without gestational diabetes (GDM); and to relate them with maternal glucose, lipid profile and weight status of babies. METHODS: GDM positive women (n = 33) and normal glucose tolerant women (NGT) (n = 33) were recruited. Maternal blood samples were collected at 28th week of gestation and later at 6-week post-partum while breast milk samples of the lactating mothers were collected within 72 hours of birth (colostrum) and at 6 weeks post-partum (mature milk)...
April 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29608495/medical-management-of-rheumatic-heart-disease-a-systematic-review-of-the-evidence
#16
E Anne Russell, Warren F Walsh, Ben Costello, Alex Ja McLellan, Alex Brown, Christopher M Reid, Lavinia Tran, Graeme P Maguire
Rheumatic heart disease (RHD) is an important cause of heart disease globally. Its management can encompass medical and procedural (catheter and surgical) interventions. Literature pertaining to the medical management of RHD from PubMed 1990-2016 and via selected article reference lists was reviewed. Areas included symptom management, left ventricular (LV) dysfunction, rate control in mitral stenosis (MS), atrial fibrillation (AF), anticoagulation, infective endocarditis prophylaxis and management in pregnancy...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29602889/adult-scurvy-associated-with-psychiatric-disorders-and-breast-feeding
#17
Stefania Urueña-Palacio, Bruno L Ferreyro, Lucas G Fernández-Otero, Pablo D Calo
Scurvy is a nutritional disease caused by ascorbic acid deficiency and is potentially fatal. It was originally described in the 18th century by James Lind and associated with long sea voyages and insufficient citrus consumption. Its prevalence has declined markedly over the years but has still been described sporadically in certain countries. A 22-year-old woman with an anxiety disorder and anorexia nervosa, recent pregnancy and ongoing breast feeding, presented with a 10-day history of spontaneous haematomas in the lower limbs, gingivorrhagia and fatigue...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29601430/breast-feeding-and-practice-tips-for-case-managers
#18
Stephanie DeVane-Johnson, Yvette J Wright, LaKasha Godwin, Janiya Mitnaul Williams
No abstract text is available yet for this article.
May 2018: Professional Case Management
https://www.readbyqxmd.com/read/29599166/tramadol-breast-feeding-and-safety-in-the-newborn
#19
Greta M Palmer, Brian J Anderson, David K Linscott, Michael J Paech, Karel Allegaert
No abstract text is available yet for this article.
March 29, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29593659/how-to-control-htlv-1-associated-diseases-preventing-de-novo-cellular-infection-using-antiviral-therapy
#20
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a severe HTLV-1-associated disease: Adult-T-cell leukemia/lymphoma (ATLL), or a neurological disorder named Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). In vivo , HTLV-1 is mostly detected in CD4+ T-cells, and to a lesser extent in CD8+ T cells and dendritic cells...
2018: Frontiers in Microbiology
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