Kush P Patel, Paul Richard Scully, Christian Nitsche, Andreas A Kammerlander, George Joy, George Thornton, Rebecca Hughes, Suzanne Williams, Therese Tillin, Gabriella Captur, Liza Chacko, Andrew Kelion, Nikant Sabharwal, James D Newton, Simon Kennon, Mick Ozkor, Michael Mullen, Philip N Hawkins, Julian D Gillmore, Leon Menezes, Francesca Pugliese, Alun D Hughes, Marianna Fontana, Guy Lloyd, Thomas A Treibel, Julia Mascherbauer, James C Moon
OBJECTIVE: The coexistence of wild-type transthyretin cardiac amyloidosis (ATTR) is common in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). However, the impact of ATTR and AS on the resultant AS-ATTR is unclear and poses diagnostic and management challenges. We therefore used a multicohort approach to evaluate myocardial structure, function, stress and damage by assessing age-related, afterload-related and amyloid-related remodelling on the resultant AS-ATTR phenotype...
January 2022: Heart