Read by QxMD icon Read


Mario Arturo Alonso-Vanegas, Iván D Freire Carlier, Daniel San-Juan, Alma Rosa Martínez, Carlos Trenado
BACKGROUND AND OBJECTIVE: The parahippocampal gyrus plays an important role in the epileptogenic pathways of mesial temporal lobe epilepsy caused by hippocampal sclerosis (mTLE-HS); its resection could prevent epileptic seizures with fewer complications. This study evaluates the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalohipppocampectomy (SAH), and parahippocampectomy (PHC) surgical approaches in mTLE-HS. METHODS: A randomized comparative pilot clinical trial (2008-2011) was performed that included patients with mTLE-HS who underwent ATL, trans-T3 SAH, and trans-T3 PHC...
February 2018: World Neurosurgery
G A Martínez-Levy, L Rocha, F Rodríguez-Pineda, M A Alonso-Vanegas, A Nani, R M Buentello-García, M Briones-Velasco, D San-Juan, J Cienfuegos, C S Cruz-Fuentes
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of BDNF messenger for the exon VI in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. Altered levels of this particular transcript were also associated with pre-surgical use of certain psychotropic...
May 2018: Molecular Neurobiology
Mario A Alonso Vanegas, Sean M Lew, Michiharu Morino, Stenio A Sarmento
Temporal lobe resection is the most prevalent epilepsy surgery procedure. However, there is no consensus on the best surgical approach to treat temporal lobe epilepsy. Complication rates are low and efficacy is very high regarding seizures after such procedures. However, there is still ample controversy regarding the best surgical approach to warrant maximum seizure control with minimal functional deficits. We describe the most frequently used microsurgical techniques for removal of both the lateral and mesial temporal lobe structures in the treatment of medically intractable temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (corticoamygdalohippocampectomy and selective amygdalohippocampectomy)...
April 2017: Epilepsia
Mario A Alonso-Vanegas, Daniel San-Juan, Ricardo M Buentello García, Carlos Castillo-Montoya, Horacio Sentíes-Madrid, Erika Brust Mascher, Paul Shkurovick Bialik, Carlos Trenado
OBJECTIVE Supplementary motor area (SMA) epilepsy is a well-known clinical condition; however, long-term surgical outcome reports are scarce and correspond to small series or isolated case reports. The aim of this study is to present the surgical results of SMA epilepsy patients treated at 2 reference centers in Mexico City. METHODS For this retrospective descriptive study (1999-2014), 52 patients underwent lesionectomy and/or corticectomy of the SMA that was guided by electrocorticography (ECoG). The clinical, neurophysiological, neuroimaging, and pathological findings are described...
November 2017: Journal of Neurosurgery
Daniel Juárez-Rebollar, Mario Alonso-Vanegas, Concepción Nava-Ruíz, Masao Buentello-García, Petra Yescas-Gómez, Araceli Díaz-Ruíz, Camilo Rios, Marisela Méndez-Armenta
Epilepsy is characterized by spontaneous recurrent seizures and temporal lobe epilepsy (TLE) is the most common serious neurological example of acquired and frequent epilepsy. Oxidative stress is recognized as playing a contributing role in several neurological disorders, and most recently have been implicated in acquired epilepsies. The MTs occur in several brain regions and may serve as neuroprotective proteins against reactive oxygen species causing oxidative damage and stress. The main aim of this work was to describe the immunohistochemical localization of MT in the specimens derived from the patients affected by TLE...
May 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Mario A Alonso-Vanegas, Eduardo Quintero-López, Juan C Moreira-Holguín, Adrián Axallacan Martínez-Albarrán, Roberto Corona-Cedillo, Juan L Gómez-Amador
Persistent trigeminal artery (PTA), also called primitive trigeminal artery, represents the most common embryonic remnant of fetal circulation in adulthood, (only after fetal pattern of posterior communicating artery [PComA]) with an estimated incidence of between 0.1% and 0.76%. The permanence of this fetal pattern constitutes an incidental finding in most cases, however, may be associated with aneurysms, arteriovenous malformations, trigeminal neuralgia, and other types of fetal circulation persistency. A patient with giant aneurysm in the communicating segment of the right internal carotid artery, associated with the presence of PTA and fetal pattern of PComA, also on the right side is reported...
January 2017: Annals of Vascular Surgery
Daniel San-Juan, León Morales-Quezada, Adolfo Josué Orozco Garduño, Mario Alonso-Vanegas, Maricarmen Fernández González-Aragón, Dulce Anabel Espinoza López, Rafael Vázquez Gregorio, David J Anschel, Felipe Fregni
No abstract text is available yet for this article.
May 2016: Brain Stimulation
Ivette Bañuelos-Cabrera, Manola Cuéllar-Herrera, Ana Luisa Velasco, Francisco Velasco, Mario Alonso-Vanegas, Francia Carmona, Rosalinda Guevara, José-Antonio Arias-Montaño, Luisa Rocha
Experiments were designed to evaluate the tissue content of tele-methylhistamine (t-MeHA) and histamine as well as H3 receptor (H3 Rs) binding and activation of the heterotrimeric guanine nucleotide binding αi/o proteins (Gαi/o) coupled to these receptors in the hippocampus and temporal neocortex of patients (n = 10) with pharmacoresistant mesial temporal lobe epilepsy (MTLE). Patients with MTLE showed elevated tissue content of t-MeHA in the hippocampus. Analyses revealed that a younger age at seizure onset was correlated with a higher tissue content of t-MeHA, lower H3 R binding, and lower efficacy of Gαi/o protein activation in the hippocampus...
April 2016: Epilepsia
Mario Arturo Alonso-Vanegas, Eduardo Quintero-López, Adrián Axallacan Martínez-Albarrán, Juan Carlos Moreira-Holguín
BACKGROUND: The herpes simplex virus (HSV) is the most common cause of sporadic encephalitis worldwide. Even with proper treatment, this infection is associated with a mortality rate of 19%-30% and with potential neurologic sequelae. Recurrences of encephalitis are rare and limited to a few cases in the literature. Although the mechanism of reactivation has not yet been clarified, in our patient, the surgery might have acted as a precipitating factor. CASE DESCRIPTION: The case involved a female 10-year-old patient with a history of type 1 HSV encephalitis since 24 months of age...
May 2016: World Neurosurgery
G A Martínez-Levy, L Rocha, F D Lubin, M A Alonso-Vanegas, A Nani, R M Buentello-García, R Pérez-Molina, M Briones-Velasco, F Recillas-Targa, A Pérez-Molina, D San-Juan, J Cienfuegos, C S Cruz-Fuentes
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampi of patients with pharmaco-resistant temporal lobe epilepsy (TLE) (n=24). Hippocampal sclerosis (HS) and pre-surgical pharmacological treatment were considered as clinical independent variables...
February 9, 2016: Neuroscience
Mario A Alonso-Vanegas, Salvador Vergara-López
No abstract text is available yet for this article.
September 2015: Gaceta Médica de México
Daniel San-Juan, León Morales-Quezada, Adolfo Josué Orozco Garduño, Mario Alonso-Vanegas, Maricarmen Fernández González-Aragón, Dulce Anabel Espinoza López, Rafael Vázquez Gregorio, David J Anschel, Felipe Fregni
BACKGROUND: Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation therapy in epilepsy with conflicting results in terms of efficacy and safety. OBJECTIVE: Review the literature about the efficacy and safety of tDCS in epilepsy in humans and animals. METHODS: We searched studies in PubMed, MedLine, Scopus, Web of Science and Google Scholar (January 1969 to October 2013) using the keywords 'transcranial direct current stimulation' or 'tDCS' or 'brain polarization' or 'galvanic stimulation' and 'epilepsy' in animals and humans...
May 2015: Brain Stimulation
Manola Cuellar-Herrera, Ana Luisa Velasco, Francisco Velasco, David Trejo, Mario Alonso-Vanegas, Avril Nuche-Bricaire, Daruni Vázquez-Barrón, Rosalinda Guevara-Guzmán, Luisa Rocha
The 5-hydroxytryptamine-1A (5-HT1A) receptors are known to be involved in the inhibition of seizures in epilepsy. Moreover, studies propose a role for the 5-HT1A receptor in memory function; it is believed that the higher density of this receptor in the hippocampus plays an important role in its regulation. Positron emission tomography (PET) studies in patients with mesial temporal lobe epilepsy (mTLE) have demonstrated that a decrease in 5-HT1A receptor binding in temporal regions may play a role in memory impairment...
December 2014: Epilepsy Research
Daniel San-Juan, Iván Cesár Díaz-Nuñez, Mónica Ojeda-Baldéz, Víctor Armando Barajas-Juárez, Iliana González-Hernández, Mario Alonso-Vanegas, David J Anschel, Jesús Delgado de la Mora, Ned Merari Davila-Avila, Carlos Alfonso Romero-Gameros, Rafael Vázquez-Gregorio, Axel Hernández-Ruíz
AIM: To describe the general aspects of cavernomas and epilepsy and review the available literature on the utility of electrocorticography (ECoG) in cerebral cavernoma surgery. METHODS: We searched studies in PubMed, MedLine, Scopus, Web of Science, and Google Scholar (from January 1969 to December 2013) using the keywords "electrocorticography" or "ECoG" or "prognosis" or "outcome" and "cavernomas". Original articles that reported utility of ECoG in epilepsy surgery were included...
September 2014: Epileptic Disorders: International Epilepsy Journal with Videotape
Luisa Rocha, Mario Alonso-Vanegas, Sandra Orozco-Suárez, David Alcántara-González, Humberto Cruzblanca, Elena Castro
It is well known that mood disorders are highly prevalent in patients with epilepsy. Although several studies have aimed to characterize alterations in different types of receptors associated with both disturbances, there is a lack of studies focused on identifying the causes of this comorbidity. Here, we described some changes at the biochemical level involving serotonin, dopamine, and γ-aminobutyric acid (GABA) receptors as well as signal transduction mechanisms that may explain the coexistence of both epilepsy and mood disorders...
September 2014: Epilepsy & Behavior: E&B
Felix Rosenow, Mario A Alonso-Vanegas, Christoph Baumgartner, Ingmar Blümcke, Maria Carreño, Elke R Gizewski, Hajo M Hamer, Susanne Knake, Philippe Kahane, Hans O Lüders, Gary W Mathern, Katja Menzler, Jonathan Miller, Taisuke Otsuki, Cigdem Ozkara, Asla Pitkänen, Steven N Roper, Americo C Sakamoto, Ulrich Sure, Matthew C Walker, Bernhard J Steinhoff
Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve postoperative seizure freedom in only about 75% of cases. This is frequently because insufficient efforts are made to adequately define and resect the epileptogenic zone...
December 2013: Epilepsia
Mario Arturo Alonso-Vanegas, José Miguel Cisneros-Franco, Carlos Castillo-Montoya, Alma Rosa Martínez-Rosas, María Esther Gómez-Pérez, Francisco Rubio-Donnadieu
AIM: This work explores the effects of clinical variables on self-reported quality of life (QoL) in pharmacoresistant temporal lobe epilepsy (TLE), correlating this information with results from the Quality of Life in Epilepsy questionnaire (QOLIE-31) and selective memory tests of the Barcelona Battery and the Rey-Osterrieth figure. METHODS: We retrospectively analysed the records of 60 TLE patients and correlated patient variables (e.g. gender, aetiology; mesial TLE with hippocampal sclerosis [HS] versus lesional TLE, side of ictal onset, age, age at onset, duration of epilepsy, seizure frequency, and use of AEDs) with selective memory test scores and self-reported QoL...
September 2013: Epileptic Disorders: International Epilepsy Journal with Videotape
Daniel San-Juan, Adriana Patricia M Mayorga, Juan de Dios Del Castillo Calcáneo, Maricarmen Fernández González-Aragón, Mario Alonso-Vanegas, Carolina Domínguez Rico, Richard J Staba, David J Anschel, Andrew J Cole
PURPOSE: Periodic epileptiform discharges (PEDs) are an uncommon, abnormal EEG pattern seen usually in patients with acute diseases and less frequently in chronic conditions, such as mesial temporal lobe epilepsy (mTLE). Evaluate the clinical histories, neuroimaging findings, and serial electrophysiological studies prior to the appearance of PEDs in patients with mTLE secondary to hippocampal sclerosis (HS). METHODS: We searched 19, 375 EEGs (2006-2012) for the presence of PEDs secondary to mTLE due to HS...
November 2013: Seizure: the Journal of the British Epilepsy Association
Jorge G Burneo, Jose C Delgado, David A Steven, Carlos M Vasquez, Mario A Alonso-Vanegas, Jose E Cavazos, Lizardo Mija, Willy Zapata, Lucio Portilla
We report the achievements obtained, over a period of 4 years, by the collaborative partnering effort of the Epilepsy Program at Western University in Canada and the Instituto of Ciencias Neurologicas in Lima, Peru, building an epilepsy program in Peru.
January 2013: Epilepsy & Behavior: E&B
Raul Lopez-Serna, Juan Luis Gómez-Amador, Juan Barges-Coll, Edgar Nathal-Vera, Rogelio Revuelta-Gutiérrez, Mario Alonso-Vanegas, Miguel Ramos-Peek, Lesly Portocarrero-Ortiz
BACKGROUND AND AIMS: Craniopharyngioma is a rare and mostly benign epithelial tumor of the central nervous system, mostly affecting children. Considering that most of the published series of craniopharyngioma are based on pediatric populations, studies in adults gain importance based mainly on the reduced number of cases and the possible differences emerging from a mostly different histological type. We undertook this study to establish the pattern of presentation, morphological features and specific characteristics of craniopharyngioma in an adult Mexican population, as well as discussing the long-term outcome and how it may be influenced by surgical, anatomic and clinical factors...
July 2012: Archives of Medical Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"