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https://www.readbyqxmd.com/read/28337770/hypoglycemic-effect-of-hawthorn-in-type-ii-diabetes-mellitus-rat-model
#1
Aili Aierken, Tina Buchholz, Chen Chen, Xiaoying Zhang, Matthias F Melzig
BACKGROUND: Hawthorn is one of the popular herbs in many different traditional medicine systems including in Traditional Chinese Medicine (TCM), where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities are still remaining unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups. Normal control group (NC), type II diabetic model group (T2DM, T2DM rats were induced by high fat diet and streptozotocin), high, middle and low concentrations of hawthorn treat groups (HTH , HTM and HTL , T2DM rats were given hawthorn extract at the dose of 50, 100 and 200 mg kg ^-1...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28333881/outer-retinal-layer-thickness-as-good-visual-predictor-in-patients-with-diabetic-macular-edema
#2
Tamer F Eliwa, Mahdi A Hussein, Mohamed A Zaki, Osama A Raslan
PURPOSE: To evaluate the relationship between outer retinal layer (ORL) thickness in diabetic macular edema to visual acuity (VA). METHODS: Ninety-five eyes were included in this prospective nonrandomized case-control study. They divided into 30 cases of healthy normal subjects and 65 cases of nonproliferative diabetic retinopathy with diabetic macular edema. Complete ophthalmic examination and spectral domain-optical coherence tomography were done for all cases and analyzed to measure central foveal point thickness (CFT), ORL thickness at fovea, and subfoveal choroidal thickness...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28333630/multilinear-spatial-discriminant-analysis-for-dimensionality-reduction
#3
Sen Yuan, Xia Mao, Lijiang Chen
In the last few years, great efforts have been made to extend linear projection technique (LPT) for multidimensional data (i.e. tensor), generally referred to as multilinear projection technique (MPT). The vectorized nature of LPT requires high dimensional data to be converted to vector, hence may lose spatial neighborhood information of raw data. MPT well addresses this problem by encoding multidimensional data as general tensors of second or even higher order. In this paper, we propose a novel multilinear projection technique, called multilinear spatial discriminant analysis (MSDA), to identify the underlying manifold of high-order tensor data...
March 21, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28281039/proceedings-of-the-rami-section-of-otorhinolaryngology-head-and-neck-surgery-orl-hns-spring-meeting-friday-9th-december-2016-education-and-research-centre-royal-victoria-eye-and-ear-hospital-adelaide-road-dublin-2
#4
https://www.readbyqxmd.com/read/28212930/molecular-recognition-between-pancreatic-lipase-and-natural-and-synthetic-inhibitors
#5
Martiniano Bello, Lucia Basilio-Antonio, Jonathan Fragoso-Vázquez, Anaguiven Avalos-Soriano, José Correa-Basurto
Pancreatic lipase (PL) is a primary lipase critical for triacylglyceride digestion in humans and is considered as a promising target for the treatment of obesity. Although the current synthetic drugs available for treating obesity have been demonstrated to be effective in inhibiting PL, their prolonged usage results in severe side effects. Based on this argument, in this study, we evaluated the structural and energetic features linked to molecular recognition between two well-known PL inhibitors, orlistat (ORL, synthetic inhibitor) and (-)-epigallocatechin gallate (EGCG, natural inhibitor) and PL through molecular dynamics simulations and free energy calculations of ORL and EGCG at the PL binding site when it is isolated (PL) from the heterodimer complex, forming the heterodimer complex with colipase (PLCL) and lacking structural calcium...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28211879/evaluation-of-choroidal-tumors-with-optical-coherence-tomography-enhanced-depth-imaging-and-oct-angiography-features
#6
G Cennamo, M R Romano, M A Breve, N Velotti, M Reibaldi, G de Crecchio, G Cennamo
AimTo describe the vascular features of choroidal tumors using enhanced depth imaging (EDI), optical coherence tomography (OCT), and OCT-angiography.MethodsIn this prospective study, we evaluated 116 Caucasian patients with choroidal tumors (60 eyes with choroidal nevi, 40 with choroidal melanoma, 6 with choroidal hemangioma, 2 with optic disc melanocytoma, 6 with choroidal osteoma, and 2 with retinal metastases). Patients underwent a complete ophthalmic examination including bulbar echography, EDI-OCT, OCT-angiography, and multicolor imaging...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28154929/first-intraoperative-experience-with-three-dimensional-3d-high-definition-hd-nasal-endoscopy-for-lacrimal-surgeries
#7
Mohammad Javed Ali, Milind N Naik
The aim of this study is to report our preliminary experiences with regard to safety and feasibility of three-dimensional (3D) endoscopic lacrimal surgeries with a recently launched latest generation 3D endoscope. A 4-mm rigid three-dimensional (3D) endoscope (TIPCAM 1S 3D ORL(R), Karl Storz, Tuttlingen, Germany) was used. Fifteen patients who underwent various endoscopic lacrimal procedures by a single surgeon (MJA) were included. The procedures included probing with nasolacrimal intubation, cruciate marsupialization of intranasal cysts for congenital dacryoceles, powered endoscopic dacryocystorhinostomy, post-operative stent removal with ostium granuloma excision...
February 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28124184/reelin-deficiency-delays-mammary-tumor-growth-and-metastatic-progression
#8
Elvira Khialeeva, Joan W Chou, Denise E Allen, Alec M Chiu, Steven J Bensinger, Ellen M Carpenter
Reelin is a regulator of cell migration in the nervous system, and has other functions in the development of a number of non-neuronal tissues. In addition, alterations in reelin expression levels have been reported in breast, pancreatic, liver, gastric, and other cancers. Reelin is normally expressed in mammary gland stromal cells, but whether stromal reelin contributes to breast cancer progression is unknown. Herein, we used a syngeneic mouse mammary tumor transplantation model to examine the impact of host-derived reelin on breast cancer progression...
March 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28114081/joint-sparse-representation-and-embedding-propagation-learning-a-framework-for-graph-based-semisupervised-learning
#9
Xiaobing Pei, Chuanbo Chen, Yue Guan
In this paper, we propose a novel graph-based semisupervised learning framework, called joint sparse representation and embedding propagation learning (JSREPL). The idea of JSREPL is to join EPL with sparse representation to perform label propagation. Like most of graph-based semisupervised propagation learning algorithms, JSREPL also constructs weights graph matrix from given data. Different from classical approaches which build weights graph matrix and estimate the labels of unlabeled data in sequence, JSREPL simultaneously builds weights graph matrix and estimates the labels of unlabeled data...
September 28, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28109483/otorhinolaryngology-head-and-neck-surgery-in-a-low-income-country-the-haitian-experience
#10
Maxwell P Kligerman, Anahuma Alexandre, Patrick Jean-Gilles, David Walmer, Mack L Cheney, Anna H Messner
OBJECTIVE: Little is known regarding the diagnosis and management of pediatric surgical conditions of the head and neck in low-income countries. Haiti, the western hemisphere's poorest country, recently developed its first Otorhinolaryngology (ORL) department at the Hopital de L'Universite d'Etat d'Haiti (HUEH). This manuscript assesses the caseload at HUEH with a special emphasis on pediatric cases, with the aim of characterizing ORL related conditions and their treatments in low-income countries...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28068880/low-intensity-vibrations-normalize-adipogenesis-induced-morphological-and-molecular-changes-of-adult-mesenchymal-stem-cells
#11
Oznur Baskan, Gulistan Mese, Engin Ozcivici
Bone marrow mesenchymal stem cells that are committed to adipogenesis were exposed daily to high-frequency low-intensity mechanical vibrations to understand molecular, morphological and ultrastructural adaptations to mechanical signals during adipogenesis. D1-ORL-UVA mouse bone marrow mesenchymal stem cells were cultured with either growth or adipogenic medium for 1 week. Low-intensity vibration signals (15 min/day, 90 Hz, 0.1 g) were applied to one group of adipogenic cells, while the other adipogenic group served as a sham control...
February 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28058624/zebrafish-phenotypic-screen-identifies-novel-notch-antagonists
#12
Vithya Velaithan, Kazuhide Shaun Okuda, Mei Fong Ng, Norazwana Samat, Sze Wei Leong, Siti Munirah Mohd Faudzi, Faridah Abas, Khozirah Shaari, Sok Ching Cheong, Pei Jean Tan, Vyomesh Patel
Zebrafish represents a powerful in vivo model for phenotype-based drug discovery to identify clinically relevant small molecules. By utilizing this model, we evaluated natural product derived compounds that could potentially modulate Notch signaling that is important in both zebrafish embryogenesis and pathogenic in human cancers. A total of 234 compounds were screened using zebrafish embryos and 3 were identified to be conferring phenotypic alterations similar to embryos treated with known Notch inhibitors...
January 5, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28032481/safety-tolerability-and-antihypertensive-effect-of-ser100-an-opiate-receptor-like-1-orl-1-partial-agonist-in-patients-with-isolated-systolic-hypertension
#13
Ilkka Kantola, Mika Scheinin, Trygve Gulbrandsen, Nils Meland, Knut T Smerud
The purpose of the present trial was to evaluate safety, tolerability, and effect on systolic blood pressure (SBP) of SER100 in a small group of patients with isolated systolic hypertension (ISH) in treatment with at least 1 antihypertensive drug. Eligible patients were randomized to either SER100 (10 mg) or placebo in a crossover design, and 2 doses were given subcutaneously (SC), 8 hours apart, on 2 consecutive days. On all treatment days patients were monitored with an ambulatory blood pressure measurement device for 12 daytime hours...
December 29, 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28012521/subspecialist-training-program-in-pediatric-otorhinolaryngology-of-uems-orl-hns-section
#14
Tomislav Baudoin
The ORL Section and Board of Otorhinolaryngology-Head and Neck Surgery of the European Union of Medical Specialists (UEMS) developed pediatric ORL subspecialty program. The program was created with support and consultation of the European Society of Pediatric Otorhinolaryngology. It is divided into four sections: Pediatric Otology, Pediatric Rhinology and Facial Plastic Surgery, Pediatric Laryngology and Phoniatrics and Pediatric Head and Neck Surgery. After completion of the program, the trainee is supposed to achieve an advanced level of competency...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27993717/mapping-transmembrane-residues-of-proteinase-activated-receptor-2-par2-that-influence-ligand-modulated-calcium-signaling
#15
J Y Suen, M N Adams, J Lim, P K Madala, W Xu, A J Cotterell, Y He, M K Yau, J D Hooper, D P Fairlie
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor involved in metabolism, inflammation, and cancers. It is activated by proteolysis, which exposes a nascent N-terminal sequence that becomes a tethered agonist. Short synthetic peptides corresponding to this sequence also activate PAR2, while small organic molecules show promising PAR2 antagonism. Developing PAR2 ligands into pharmaceuticals is hindered by a lack of knowledge of how synthetic ligands interact with and differentially modulate PAR2...
December 16, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27990369/macular-changes-of-neuromyelitis-optica-through-spectral-domain-optical-coherence-tomography
#16
Lu Cheng, Jing Wang, Xu He, Xun Xu, Zhen-Fen Ling
AIM: To evaluate the thickness of the retinal layers in the macula using spectral-domain optical coherence tomography (SD-OCT) in patients with neuromyelitis optica (NMO). METHODS: Spectralis SD-OCT, utilizing automated macular layer segmentation, was performed in 26 NMO patients and 26 healthy controls. Visual function including visual field tests and pattern visual evoked potential were recorded in study subjects. RESULTS: Forty-one eyes from 26 NMO patients and 52 eyes from 26 age- and sex-matched healthy controls were included...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27977506/management-of-pediatric-acute-mastoiditis-in-israel-nationwide-survey-among-otorhinolaryngologists-and-emergency-pediatricians
#17
Sharon Tamir Ovnat, Tal Marom, David Rekhtman, Michal Luntz
INTRODUCTION: Acute mastoiditis (AM) is a medical emergency that mandates prompt diagnosis and treatment. Nevertheless, its management often differs between otorhinolaryngologists (ORLs) and pediatricians (PEDs) working in emergency departments. We sought to characterize the similarities and differences between management protocols of these 2 disciplines. MATERIALS AND METHODS: A voluntary electronic questionnaire, including 17 items pertaining to pediatric AM management, was sent to all the 20 otorhinolaryngology and their corresponding pediatric emergency departments nationwide...
December 13, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27958598/advanced-oxidation-protein-product-levels-as-a-marker-of-oxidative-stress-in-paediatric-patients-with-chronic-tonsillitis
#18
I Ozbay, C Kucur, F E Koçak, B Savran, F Oghan
We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a marker of oxidative stress in paediatric patients with chronic tonsillitis. Thirty children with chronic tonsillitis and 30 healthy children (control group) were recruited from the Otorhinolaryngology (ORL) and Paediatric Surgery departments, respectively, of Dumlupinar University Hospital. In the patient group, blood samples were collected before tonsillectomy, and tonsil tissue was sampled during the operation. Blood samples were also obtained from the control subjects...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27914024/laparoscopic-hepatectomy-for-hcc-in-elderly-patients-risks-and-feasibility
#19
Bruno Amato, Giovanni Aprea, Davide De Rosa, Marco Milone, Lorenza di Domenico, Maurizio Amato, Rita Compagna, Mario Santoro, Louis Banka Johnson, Alessandro Sanguinetti, Andrea Polistena, Nicola Avenia
BACKGROUND: Laparoscopic liver resection (LLR) appears to be safe and effective as open liver resection (OLR) for hepatocellular carcinoma (HCC). However, studies comparing LLR with ORL in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of LLR versus OLR for HCC in elderly patients. METHODS: A retrospective analysis was made comparing laparoscopic (n = 11) and open (n = 18) liver resections in elderly patients performed at the University of Naples "Federico II" between January 2010 and December 2014...
December 2, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27871559/quality-of-recovery-from-anesthesia-of-patients-undergoing-balanced-or-total-intravenous-general-anesthesia-prospective-randomized-clinical-trial
#20
Eduardo Toshiyuki Moro, Fábio Caetano Oliveira Leme, Bernardo Roveda Noronha, Gustavo Farinha Pinto Saraiva, Nathália Vianna de Matos Leite, Laís Helena Camacho Navarro
STUDY OBJECTIVES: The aim of the present study was to assess the quality of recovery from anesthesia of patients subjected to otorhinolaryngological (ORL) surgery under balanced or total intravenous general anesthesia by means of Quality of Recovery-40 (QoR-40) questionnaire. DESIGN: Prospective randomized clinical trial. SETTING: The setting is at an operating room, a postoperative recovery area, and a hospital ward. PATIENTS: One-hundred thirty American Society of Anesthesiologists physical status I or II patients scheduled to undergo general anesthesia for ORL interventions under remifentanil, in combination with sevoflurane (balanced technique) or propofol (total intravenous anesthesia)...
December 2016: Journal of Clinical Anesthesia
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