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https://www.readbyqxmd.com/read/28728469/characterizing-patients-with-multiple-chromosomal-aberrations-detected-by-fish-in-chronic-lymphocytic-leukemia
#1
Isabel González-Gascón Y Marín, María Hernández-Sanchez, Ana Eugenia Rodríguez-Vicente, Anna Puiggros, Rosa Collado, Elisa Luño, Teresa González, Neus Ruiz-Xivillé, Margarita Ortega, Eva Gimeno, Carolina Muñoz, Maria Stefania Infante, Julio Delgado, María Teresa Vargas, Marcos González, Francesc Bosch, Blanca Espinet, Jesús María Hernández-Rivas, José Ángel Hernández
We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months)...
July 21, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28681503/gene-cloning-characterization-and-cytotoxic-activity-of-methionine-%C3%AE-lyase-from-clostridium-novyi
#2
Vitalia V Kulikova, Elena A Morozova, Svetlana V Revtovich, Mikhail I Kotlov, Natalya V Anufrieva, Natalya P Bazhulina, Samanta Raboni, Serena Faggiano, Edi Gabellieri, Patrizia Cioni, Yury F Belyi, Andrea Mozzarelli, Tatyana V Demidkina
The exploitation of methionine-depleting enzyme methionine γ-lyase (MGL) is a promising strategy against specific cancer cells that are strongly dependent on methionine. To identify MGL from different sources with high catalytic activity and efficient anticancer action, we have expressed and characterized MGL from Clostridium novyi and compared its catalytic efficiency with the previously studied MGL from Citrobacter freundii. The purified recombinant MGL exhibits kcat and kcat /Km for methionine γ-elimination reaction that are 2...
July 6, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28236475/update-of-the-grupo-espa%C3%A3-ol-de-leucemia-linfoc%C3%A3-tica-cr%C3%A3-nica-clinical-guidelines-of-the-management-of-chronic-lymphocytic-leukemia
#3
José A García-Marco, Julio Delgado, José A Hernández-Rivas, Ángel Ramírez Payer, Javier Loscertales Pueyo, Isidro Jarque, Pau Abrisqueta, Pilar Giraldo, Rafael Martínez, Lucrecia Yáñez, Mª José Terol, Marcos González, Francesc Bosch
BACKGROUND AND OBJECTIVE: The broad therapeutic arsenal and the biological heterogeneity of patients with chronic lymphocytic leukemia (CLL) makes it difficult to standardize treatment for CLL patients with specific clinical settings in routine clinical practice. These considerations prompted us to elaborate the present consensus document, which constitutes an update of the previous version published in 2013, mainly focusing on novel treatment strategies that have been developed over last 5 years, namely B-cell receptor inhibitors (ibrutinib and idelalisib), anti-CD20 monoclonal antibodies (ofatumumab and obinutuzumab), and Bcl-2 inhibitors (venetoclax)...
April 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28198960/quality-of-life-of-patients-with-graft-versus-host-disease-gvhd-post-hematopoietic-stem-cell-transplantation
#4
Sibéli de Fátima Ferraz Simão Proença, Celina Mattos Machado, Raquel de Castro Figueiredo Pereira Coelho, Leila Maria Mansano Sarquis, Paulo Ricardo Bittencourt Guimarães, Luciana Puchalski Kalinke
OBJECTIVE: Assessing the quality of life of adult patients with hematological cancer in the 100 days after transplantation of hematopoietic stem cells and verifying whether the variable graft-versus-host disease (GvHD) is predictive of worse results. METHOD: An observational correlational and quantitative study with 36 adult participants diagnosed with hematologic cancer who underwent hematopoietic stem cell transplantation from September 2013 to June 2015. RESULT: The mean age was 37 years, 52...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27986205/costo-efectividad-del-uso-profil%C3%A3-ctico-del-factor-estimulante-de-colonias-de-granulocitos-en-adultos-con-leucemia-linfobl%C3%A3-stica-aguda-en-colombia
#5
Elkin Javier Casadiego Rincón, Jorge Augusto Díaz Rojas, Carlos Daniel Bermúdez, Víctor Prieto Martínez
OBJECTIVE: To assess the cost-effectiveness of prophylactic administration of Granulocyte Colony-Stimulating Factor (G-CSF) compared with no use of it, during the induction phase of chemotherapy in Adults with Acute Lymphoblastic Leukemia (ALL) in Colombia. METHODS: A decision tree with a time horizon of 30 days was built under colombian health system perspective including only direct costs. The costs of procedures and medications were taken from official sources and an institution of national reference of oncology services...
December 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27513487/-not-available
#6
Elena Guadalupe Corella Aznar, Ariadna Ayerza Casas, Pilar Samper Villagrasa, Carmen Rodríguez Vigil, Lorenzo Jiménez Montañés, Carlota Calvo Escribano, José Ignacio Labarta Aizpun
Introducción: los supervivientes de leucemia aguda (LA) infantil presentan un riesgo incrementado de alteraciones metabólicas y cardiovasculares que aumentan su morbimortalidad a largo plazo.Objetivo: estimar la prevalencia de obesidad, resistencia a la insulina, dislipemia e hipertensión arterial como factores de riesgo cardiometabólico (FRCM) en un grupo de supervivientes de LA infantil, y analizar las posibles causas asociadas a su desarrollo.Material y métodos: estudio observacional retrospectivo en 47 supervivientes de LA tratados en un periodo de 4 años, que recibieron seguimiento durante 10 años...
June 30, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27444459/-not-available
#7
Elena Guadalupe Corella Aznar, Ariadna Ayerza Casas, Pilar Samper Villagrasa, Carmen Rodríguez Vigil, Lorenzo Jiménez Montañés, Carlota Calvo Escribano, José Ignacio Labarta Aizpun
Introducción: los supervivientes de leucemia aguda (LA) infantil presentan un riesgo incrementado de alteraciones metabólicas y cardiovasculares que aumentan su morbimortalidad a largo plazo.Objetivo: estimar la prevalencia de obesidad, resistencia a la insulina, dislipemia e hipertensión arterial como factores de riesgo cardiometabólico (FRCM) en un grupo de supervivientes de LA infantil, y analizar las posibles causas asociadas a su desarrollo.Material y métodos: estudio observacional retrospectivo en 47 supervivientes de LA tratados en un periodo de 4 años, que recibieron seguimiento durante 10 años...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27135630/dose-dependent-protective-effect-of-baicalin-against-testicular-torsion-detorsion-in-rats
#8
A A Fouad, H O Qutub, I Jresat
Testicular torsion/detorsion induces oxidative/nitrosative stress, inflammation and apoptosis of testicular tissues. Baicalin exerts antioxidant and anti-inflammatory properties. This study investigated the possible protective effect of baicalin against testicular torsion-detorsion injury in rats. Surgical testicular torsion was induced for 2 h, followed by detorsion which was continued for 24 h. Baicalin was administered in three different doses (25, 50 and 100 mg kg(-1) , by intraperitoneal injection)...
February 2017: Andrologia
https://www.readbyqxmd.com/read/26630574/a-low-frequency-of-losses-in-11q-chromosome-is-associated-with-better-outcome-and-lower-rate-of-genomic-mutations-in-patients-with-chronic-lymphocytic-leukemia
#9
José Ángel Hernández, María Hernández-Sánchez, Ana Eugenia Rodríguez-Vicente, Vera Grossmann, Rosa Collado, Cecilia Heras, Anna Puiggros, Ana África Martín, Noemí Puig, Rocío Benito, Cristina Robledo, Julio Delgado, Teresa González, José Antonio Queizán, Josefina Galende, Ignacio de la Fuente, Guillermo Martín-Núñez, José María Alonso, Pau Abrisqueta, Elisa Luño, Isabel Marugán, Isabel González-Gascón, Francesc Bosch, Alexander Kohlmann, Marcos González, Blanca Espinet, Jesús María Hernández-Rivas
To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ hybridization (FISH) studies showed a threshold of 40% of deleted cells to be optimal for showing that clinical differences in terms of TFT and OS within 11q- CLLs. In patients with ≥40% of losses in 11q (11q-H) (74%), the median TFT was 19 months compared with 44 months in CLL patients with <40% del(11q) (11q-L) (P<0...
2015: PloS One
https://www.readbyqxmd.com/read/26603004/outcome-of-children-and-adolescents-with-lymphoblastic-lymphoma
#10
Maria Christina Lopes Araújo Oliveira, Keyla Christy Sampaio, Aline Carneiro Oliveira, Aieska Dantas Santos, Lúcia Porto Castro, Marcos Borato Viana
INTRODUCTION: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. METHODS: this is a retrospective cohort study of 27 patients aged 16 years or younger with LBL admitted between January 1981 and December 2013. Patients were treated according to the therapy protocol used for acute lymphoblastic leucemia...
September 2015: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/26190424/acute-lymphoblastic-leukemia-in-children-and-adolescents-prognostic-factors-and-analysis-of-survival
#11
Daniel Willian Lustosa de Sousa, Francisco Valdeci de Almeida Ferreira, Francisco Helder Cavalcante Félix, Marcos Vinicios de Oliveira Lopes
OBJECTIVE: To describe the clinical and laboratory features of children and adolescents with acute lymphoblastic leukemia treated at three referral centers in Ceará and evaluate prognostic factors for survival, including age, gender, presenting white blood cell count, immunophenotype, DNA index and early response to treatment. METHODS: Seventy-six under 19-year-old patients with newly diagnosed acute lymphoblastic leukemia treated with the Grupo Brasileiro de Tratamento de Leucemia da Infância - acute lymphoblastic leukemia-93 and -99 protocols between September 2007 and December 2009 were analyzed...
July 2015: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/25946529/-depression-in-school-children-and-adolescents-carriers-of-acute-leukemia-during-the-treatment-phase
#12
COMPARATIVE STUDY
Nancy Susana Rivas-Molina, Edgar Omar Mireles-Pérez, Janet Margarita Soto-Padilla, Nora Adriana González-Reyes, Tanya Lizbeth Barajas-Serrano, Juan Carlos Barrera de León
UNLABELLED: Objective: To describe depression levels in school aged children and adolescents with acute leukemia during the treatment. MATERIALS AND METHODS: This transversal descriptive study took place during January to September 2012 and included school aged children and adolescents, carriers of acute leukemia, in treatment at a high-ranking specialty hospital. A modified Kovacs questionnaire (C O/) was applied. They were grouped according to presence or absence of depression...
March 2015: Gaceta Médica de México
https://www.readbyqxmd.com/read/25946524/-analysis-of-clinical-biological-features-of-adult-acute-lymphoblastic-leukemia
#13
Rosbiney Díaz-Ruiz, Lilia Aguilar-López, Arturo Vega-Ruiz, Oscar Garcés-Ruiz, Arnulfo Nava-Zavala, Benjamín Rubio-Jurado
INTRODUCCTION: Acute lymphoblastic leukemia (ALL) is a clonal disease characterized by a proliferation of immature cells. In immunophenotypic, cytogenetic and molecular studies, it is a heterogeneous disease with diverse manifestations and prognoses. The treatment is complex and is associated with complications during its course. PATIENTS AND METHODS: A prospective study of cohort of patients with ALL. Subjects were recruited consecutively from April 2010 to November 2012 in the Specialties Hospital, /MSS...
March 2015: Gaceta Médica de México
https://www.readbyqxmd.com/read/25689772/a-high-proportion-of-cells-carrying-trisomy-12-is-associated-with-a-worse-outcome-in-patients-with-chronic-lymphocytic-leukemia
#14
MULTICENTER STUDY
Isabel González-Gascón Y Marín, María Hernández-Sánchez, Ana-Eugenia Rodríguez-Vicente, Carmen Sanzo, Anna Aventín, Anna Puiggros, Rosa Collado, Cecilia Heras, Carolina Muñoz, Julio Delgado, Margarita Ortega, María-Teresa González, Isabel Marugán, Ignacio de la Fuente, Isabel Recio, Francesc Bosch, Blanca Espinet, Marcos González, Jesús-María Hernández-Rivas, José-Ángel Hernández
The prognosis of chronic lymphocytic leukemia (CLL) patients displaying trisomy 12 (+12) remains unclear. In this study, we analyzed the influence of the proportion of cells with +12, and other clinical and biologic factors, in time to first therapy (TTFT) and overall survival (OS), in 289 patients diagnosed with CLL carrying +12. Median OS was 129 months. One hundred seventy-four patients (60.2%) presented +12 in <60% of cells. TTFT and OS for this subgroup were longer than for the subgroup with +12 in ≥60% of cells, with a median TTFT of 49 months (CI95%, 39-58) vs 30 months (CI95%, 22-38) (P = 0...
June 2016: Hematological Oncology
https://www.readbyqxmd.com/read/24915757/interstitial-13q14-deletions-detected-in-the-karyotype-and-translocations-with-concomitant-deletion-at-13q14-in-chronic-lymphocytic-leukemia-different-genetic-mechanisms-but-equivalent-poorer-clinical-outcome
#15
MULTICENTER STUDY
Anna Puiggros, Marta Venturas, Marta Salido, Gonzalo Blanco, Concepción Fernandez-Rodriguez, Rosa Collado, Alberto Valiente, Neus Ruiz-Xivillé, Ana Carrió, Francisco José Ortuño, Elisa Luño, María José Calasanz, María Teresa Ardanaz, María Ángeles Piñán, Elisabet Talavera, María Teresa González, Margarita Ortega, Isabel Marugán, Ana Ferrer, Eva Gimeno, Beatriz Bellosillo, Julio Delgado, José Ángel Hernández, Jesús María Hernández-Rivas, Blanca Espinet
Deletion of 13q14 as the sole abnormality is a good prognostic marker in chronic lymphocytic leukemia (CLL). Nonetheless, the prognostic value of reciprocal 13q14 translocations [t(13q)] with related 13q losses has not been fully elucidated. We described clinical and biological characteristics of 25 CLL patients with t(13q), and compared with 62 patients carrying interstitial del(13q) by conventional G-banding cytogenetics (CGC) [i-del(13q)] and 295 patients with del(13q) only detected by fluorescence in situ hybridization (FISH) [F-del(13q)]...
September 2014: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/24824767/multilineage-dysplasia-is-associated-with-a-poorer-prognosis-in-patients-with-de-novo-acute-myeloid-leukemia-with-intermediate-risk-cytogenetics-and-wild-type-npm1
#16
COMPARATIVE STUDY
María Rozman, José-Tomás Navarro, Leonor Arenillas, Anna Aventín, Teresa Giménez, Esther Alonso, Granada Perea, Mireia Camós, Mayda Navarrete, Esperanza Tuset, Lourdes Florensa, Fuensanta Millá, Josep Nomdedéu, Esmeralda de la Banda, Marina Díaz-Beyá, Marta Pratcorona, Ana Garrido, Blanca Navarro, Salut Brunet, Jorge Sierra, Jordi Esteve
Acute myeloid leukemia (AML) with myelodysplasia-related changes is characterized by the presence of multilineage dysplasia (MLD), frequently related to high-risk cytogenetics and poor outcome. However, the presence of MLD does not modify the favorable prognostic impact of NPM1 mutation. The prognosis of patients with AML presenting marked dysplasia lacking high-risk cytogenetics and NPM1 mutation is uncertain. We evaluated the prognostic impact of MLD in 177 patients with intermediate-risk cytogenetics AML (IR-AML) and wild-type NPM1...
October 2014: Annals of Hematology
https://www.readbyqxmd.com/read/24072101/microrna-expression-at-diagnosis-adds-relevant-prognostic-information-to-molecular-categorization-in-patients-with-intermediate-risk-cytogenetic-acute-myeloid-leukemia
#17
M Díaz-Beyá, S Brunet, J Nomdedéu, R Tejero, T Díaz, M Pratcorona, M Tormo, J M Ribera, L Escoda, R Duarte, D Gallardo, I Heras, M P Queipo de Llano, J Bargay, M Monzo, J Sierra, A Navarro, J Esteve
Acute myeloid leukemia (AML) is a heterogeneous disease, and optimal treatment varies according to cytogenetic risk factors and molecular markers. Several studies have demonstrated the prognostic importance of microRNAs (miRNAs) in AML. Here we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group. We first profiled 670 miRNAs in a subset of 85 IR-AML patients from a single institution and identified 10 outcome-related miRNAs...
April 2014: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/23869550/biallelic-losses-of-13q-do-not-confer-a-poorer-outcome-in-chronic-lymphocytic-leukaemia-analysis-of-627-patients-with-isolated-13q-deletion
#18
Anna Puiggros, Julio Delgado, Ana Rodriguez-Vicente, Rosa Collado, Anna Aventín, Elisa Luño, Javier Grau, José Ángel Hernandez, Isabel Marugán, Maite Ardanaz, Teresa González, Alberto Valiente, Mar Osma, Maria José Calasanz, Carmen Sanzo, Ana Carrió, Margarita Ortega, Rodrigo Santacruz, Pau Abrisqueta, Eugènia Abella, Francesc Bosch, Félix Carbonell, Francesc Solé, Jesús Maria Hernández, Blanca Espinet
Losses in 13q as a sole abnormality confer a good prognosis in chronic lymphocytic leukaemia (CLL). Nevertheless, its heterogeneity has been demonstrated and the clinical significance of biallelic 13q deletions remains controversial. We compared the clinico-biological characteristics of a series of 627 patients harbouring isolated 13q deletions by fluorescence in situ hybridization (FISH), either monoallelic (13q × 1), biallelic (13q × 2), or the coexistence of both clones (13qM). The most frequent 13q deletion was 13q × 1 (82·1%), while 13q × 2 and 13qM represented 8·6% and 9·3% of patients respectively...
October 2013: British Journal of Haematology
https://www.readbyqxmd.com/read/23830547/-national-guidelines-for-the-management-of-patients-with-chronic-lymphocytic-leukemia-sociedad-espan%C3%AB-ola-de-hematolog%C3%A4-%C3%A2-a-y-hemoterapia-and-grupo-espan%C3%AB-ol-de-leucemia-linfoc%C3%A4-%C3%A2-tica-cro%C3%A2-nica
#19
José A García Marco, Pilar Giraldo Castellano, Javier López Jiménez, Eduardo Ríos Herranz, José Luis Sastre Moral, M José Terol Casterá, Francesc Bosch Albareda
Chronic lymphocytic leukemia is the most common chronic lymphoproliferative disorder in Spain. The clinical management of this entity varies widely. Currently, in Spain, there are no national consensus guidelines, such as those published in other countries, to guide the diagnosis and treatment of this malignancy and the use of prognostic scores. This article reviews the current scientific literature and addresses issues on the diagnosis of chronic lymphocytic leukemia, the spread of the disease, the presence of comorbidities, the classification of prognostic scores, the common treatment regimens stratified by risk factors, and the management of complications associated with both the disease and its treatment, as well as the various controversies related to this entity...
August 17, 2013: Medicina Clínica
https://www.readbyqxmd.com/read/23377436/favorable-outcome-of-patients-with-acute-myeloid-leukemia-harboring-a-low-allelic-burden-flt3-itd-mutation-and-concomitant-npm1-mutation-relevance-to-post-remission-therapy
#20
Marta Pratcorona, Salut Brunet, Josep Nomdedéu, Josep Maria Ribera, Mar Tormo, Rafael Duarte, Lourdes Escoda, Ramon Guàrdia, M Paz Queipo de Llano, Olga Salamero, Joan Bargay, Carmen Pedro, Josep Maria Martí, Montserrat Torrebadell, Marina Díaz-Beyá, Mireia Camós, Dolors Colomer, Montserrat Hoyos, Jorge Sierra, Jordi Esteve
Risk associated to FLT3 internal tandem duplication (FLT3-ITD) in patients with acute myeloid leukemia (AML) may depend on mutational burden and its interaction with other mutations. We analyzed the effect of FLT3-ITD/FLT3 wild-type (FLT3wt) ratio depending on NPM1 mutation (NPM1mut) in 303 patients with intermediate-risk cytogenetics AML treated with intensive chemotherapy. Among NPM1mut patients, FLT3wt and low ratio (<0.5) subgroups showed similar overall survival, relapse risk, and leukemia-free survival, whereas high ratio (≥0...
April 4, 2013: Blood
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