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https://www.readbyqxmd.com/read/28287024/combined-training-fndc5-irisin-levels-and-metabolic-markers-in-obese-men-a-randomised-controlled-trial
#1
Ivan Luiz Padilha Bonfante, Mara Patrícia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Wendell Arhur Lopes, Valéria Bonganha, Cleiton Augusto Libardi, Cláudia Regina Cavaglieri
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13 ± 5.75, body mass index (BMI) 30.86 ± 1.63) were randomly distributed in the CT group (n = 12) and control group (CG n = 10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28240298/glucocorticoid-receptor-positively-regulates-transcription-of-fndc5-in-the-liver
#2
Hyoung Kyu Kim, Yu Jeong Jeong, In-Sung Song, Yeon Hee Noh, Kyo Won Seo, Min Kim, Jin Han
Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human metabolic diseases. Thus, we investigated the genetic and epigenetic mechanisms that regulate expression of the FNDC5 gene. FNDC5 mRNA was strong expressed in major energy-dependent human tissues, including heart, brain, liver, and skeletal muscle...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219696/irisin-in-goldfish-carassius-auratus-effects-of-irisin-injections-on-feeding-behavior-and-expression-of-appetite-regulators-uncoupling-proteins-and-lipoprotein-lipase-and-fasting-induced-changes-in-fndc5-expression
#3
Zahndra Diann Butt, Jessica Dalton Hackett, Hélène Volkoff
Irisin is a peptide cleaved from the fibronectin type III domain containing protein 5 (FNDC5) gene that is secreted predominantly by muscle cells but also by other tissues including brain and intestine. In mammals, irisin has been shown to have thermogenic actions via the modulation of uncoupling proteins (UCPs) and to affect feeding and energy homeostasis via actions in brain, adipose tissue, liver, muscle and gastrointestinal tract. To examine the role of irisin on feeding and metabolism in fish, the effects of peripheral (intraperitoneal) injections of irisin on feeding behavior, glucose levels and the mRNA expressions of appetite regulators (cocaine and amphetamine regulated transcript CART, agouti related protein AgRP, orexin), UCPs and lipoprotein lipase LPL and brain factors (brain-derived neurotrophic factor , BDNF and tyrosine hydroxylase TH) were assessed in brain, white muscle and intestine...
February 20, 2017: Peptides
https://www.readbyqxmd.com/read/28195643/a-prospective-evaluation-of-clinical-and-genetic-predictors-of-weight-changes-in-breast-cancer-survivors
#4
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28183451/the-novel-exercise-induced-hormone-irisin-protects-against-neuronal-injury-via-activation-of-the-akt-and-erk1-2-signaling-pathways-and-contributes-to-the-neuroprotection-of-physical-exercise-in-cerebral-ischemia
#5
Dong-Jie Li, Yong-Hua Li, Hong-Bin Yuan, Le-Feng Qu, Pei Wang
BACKGROUND: Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. In this study, we investigated the potential role of irisin in cerebral ischemia and determined whether irisin is involved in the neuroprotective effect of physical exercise in mice. MATERIALS AND METHODS: The middle cerebral artery occlusion (MCAO) model was used to produce cerebral ischemia in mice. First, the plasma irisin levels and changes in expression of the irisin precursor protein FNDC5 in skeletal muscle were determined post ischemic stroke...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28144410/can-resistance-exercise-alter-irisin-levels-and-expression-profiles-of-fndc5-and-ucp1-in-rats
#6
Jalil Reisi, Kamran Ghaedi, Hamid Rajabi, Sayyed Mohammad Marandi
BACKGROUND: Irisin is a new myokine secreted from the skeletal muscle and appears to affect the metabolism of adipose tissue. OBJECTIVES: The mechanisms of cellular and molecular identification by which exercise training exerts its benefits remain unclear and are under investigation. METHODS: We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles of muscle FNDC5 and subcutaneous adipose tissue UCP1 in male rats...
December 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/28108329/exercise-increases-mitochondrial-complex-i-activity-and-drp1-expression-in-the-brains-of-aged-mice
#7
Aaron M Gusdon, Jason Callio, Giovanna Distefano, Robert M O'Doherty, Bret H Goodpaster, Paul M Coen, Charleen T Chu
Exercise is known to have numerous beneficial effects. Recent studies indicate that exercise improves mitochondrial energetics not only in skeletal muscle but also in other tissues. While exercise elicits positive effects on memory, neurogenesis, and synaptic plasticity, the effects of exercise on brain mitochondrial energetics remain relatively unknown. Herein, we studied the effects of exercise training in old and young mice on brain mitochondrial energetics, in comparison to known effects on peripheral tissues that utilize fatty acid oxidation...
April 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28070911/effects-of-exercise-training-on-brain-derived-neurotrophic-factor-in-skeletal-muscle-and-heart-of-rats-post-myocardial-infarction
#8
Heow Won Lee, Monir Ahmad, Hong-Wei Wang, Frans H H Leenen
Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible mediators fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the skeletal muscle and heart. Male Wistar rats underwent either sham surgery or ligation of left descending coronary artery, and surviving MI rats were allocated to either sedentary (Sed-MI) or exercise group (ExT-MI)...
January 9, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28028076/inorganic-nitrate-mimics-exercise-stimulated-muscular-fiber-type-switching-and-myokine-and-gaba-release
#9
Lee D Roberts, Tom Ashmore, Ben D McNally, Steven A Murfitt, Bernadette O Fernandez, Martin Feelisch, Ross Lindsay, Mario Siervo, Elizabeth A Williams, Andrew J Murray, Julian L Griffin
Exercise is an effective intervention for prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals contributing to the beneficial effects of exercise on cardiometabolic health. Inorganic nitrate increases exercise efficiency, tolerance and performance. The transcriptional regulator peroxisome proliferator-activated receptorγ coactivator1α (PGC1α) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-twitch (type IIb) to oxidative slow-twitch (type I) and intermediate (type IIa) fibers; an effect reversed in insulin resistance and diabetes...
December 27, 2016: Diabetes
https://www.readbyqxmd.com/read/28012856/increased-fndc5-irisin-expression-in-human-hepatocellular-carcinoma
#10
Melania Gaggini, Manuela Cabiati, Serena Del Turco, Teresa Navarra, Paolo De Simone, Franco Filipponi, Silvia Del Ry, Amalia Gastaldelli, Giuseppina Basta
The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still unknown. The gene expression of FNDC5/Irisin, associated to key regulators of DNL, inflammation and cancer progression was evaluated in liver tissue of 18 patients with HCC undergoing liver transplantation and of 18 deceased donors...
February 2017: Peptides
https://www.readbyqxmd.com/read/27775791/association-between-irisin-and-major-chronic-diseases-a-review
#11
M C Gouveia, J P Vella, F R Cafeo, F L Affonso Fonseca, M R Bacci
OBJECTIVE: Irisin is a muscle-secreted protein released into the circulation by cleavage of fibronectin type III domain containing protein 5(FNDC5). Since its discovery in 2012, it has been the subject of many researches due to its physiological role. It is believed that understanding irisin's function may be the key to comprehend many diseases and their development. The aim of this study is to perform a systematic review in order to establish whether there is an association of irisin's levels with obesity, diabetes mellitus, non-alcoholic steatohepatitis, chronic kidney disease and cancer in terms of prognosis...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27693813/irisin-inhibition-of-growth-hormone-secretion-in-cultured-tilapia-pituitary-cells
#12
Anji Lian, Xin Li, Quan Jiang
Irisin, the product of fibronectin type III domain-containing protein 5 (FNDC5) gene, is well-documented to be a regulator of energy metabolism. At present, not much is known about its biological function in non-mammalian species. In this study, a full-length tilapia FDNC5 was cloned and its tissue expression pattern has been confirmed. Based on the sequence obtained, we produced and purified recombinant irisin which could induce uncoupling protein 1 (UCP1) gene expression in tilapia hepatocytes. Further, the rabbit polyclonal irisin antiserum was produced and its specificity was confirmed by antiserum preabsorption...
September 30, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27693382/effects-of-physical-exercise-on-myokines-expression-and-brown-adipose-like-phenotype-modulation-in-rats-fed-a-high-fat-diet
#13
Sílvia Rocha-Rodrigues, Amaia Rodríguez, Alexandra M Gouveia, Inês O Gonçalves, Sara Becerril, Beatriz Ramírez, Jorge Beleza, Gema Frühbeck, António Ascensão, José Magalhães
AIMS: Exercise-stimulated myokine secretion into circulation may be related with browning in white adipose tissue (WAT), representing a positive metabolic effect on whole-body fat mass. However, limited information is yet available regarding the impact of exercise on myokine-related modulation of adipocyte phenotype in WAT from obese rats. MAIN METHODS: Sprague-Dawley rats (n=60) were divided into sedentary and voluntary physical activity (VPA) groups and fed with standard (35kcal% fat) or high-fat (HFD, 71kcal% fat)-isoenergetic diets...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27692156/hypothesis-irisin-is-a-metabolic-trigger-for-the-activation-of-the-neurohormonal-axis-governing-puberty-onset
#14
Fazal Wahab, Muhammad Shahab, Rüdiger Behr
A large body of data suggests that body weight influences puberty onset and adult reproduction. However, the underlying mechanism of how body weight influences puberty onset and fertility is not completely understood. The hypothalamic neuronal circuit regulating reproduction is restrained by inhibitory signals during childhood. At the time of puberty, these inhibitory signals are weakened and supplanted by stimulatory signals that, in turn, stimulate the release of gonadotropin-releasing hormone (GnRH) - a hypothalamic neuropeptide governing reproduction...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27614130/central-inhibitory-effects-on-feeding-induced-by-the-adipo-myokine-irisin
#15
Claudio Ferrante, Giustino Orlando, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Chiara Di Nisio, Rugia Shohreh, Fabio Manippa, Adriana Ricciuti, Michele Vacca, Luigi Brunetti
Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1μl, 50-200nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats...
November 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27504012/fndc5-alleviates-hepatosteatosis-by-restoring-ampk-mtor-mediated-autophagy-fatty-acid-oxidation-and-lipogenesis-in-mice
#16
Tong-Yan Liu, Xiao-Qing Xiong, Xing-Sheng Ren, Ming-Xia Zhao, Chang-Xiang Shi, Jue-Jin Wang, Ye-Bo Zhou, Feng Zhang, Ying Han, Xing-Ya Gao, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Fibronectin type III domain-containing 5 (FNDC5) protein induces browning of subcutaneous fat and mediates the beneficial effects of exercise on metabolism. However, whether FNDC5 is associated with hepatic steatosis, autophagy, fatty acid oxidation (FAO), and lipogenesis remains unknown. Herein, we show the roles and mechanisms of FNDC5 in hepatic steatosis, autophagy, and lipid metabolism. Fasted FNDC5(-/-) mice exhibited severe steatosis, reduced autophagy, and FAO, and enhanced lipogenesis in the liver compared with wild-type mice...
November 2016: Diabetes
https://www.readbyqxmd.com/read/27445983/exercise-increases-and-browns-muscle-lipid-in-high-fat-diet-fed-mice
#17
Tiffany L Morton, Kornelia Galior, Cody McGrath, Xin Wu, Gunes Uzer, Guniz Bas Uzer, Buer Sen, Zhihui Xie, David Tyson, Janet Rubin, Maya Styner
Muscle lipid increases with high-fat feeding and diabetes. In trained athletes, increased muscle lipid is not associated with insulin resistance, a phenomenon known as the athlete's paradox. To understand if exercise altered the phenotype of muscle lipid, female C57BL/6 mice fed CTL or high-fat diet (HFD for 6 or 18 weeks) were further divided into sedentary or exercising groups (CTL-E or HFD-E) with voluntary access to running wheels for the last 6 weeks of experiments, running 6 h/night. Diet did not affect running time or distance...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27436609/irisin-exerts-dual-effects-on-browning-and-adipogenesis-of-human-white-adipocytes
#18
Yuan Zhang, Chao Xie, Hai Wang, Robin M Foss, Morgan Clare, Eva Vertes George, Shiwu Li, Adam Katz, Henrique Cheng, Yousong Ding, Dongqi Tang, Westley H Reeves, Li-Jun Yang
To better understand the role of irisin in humans, we examined the effects of irisin in human primary adipocytes and fresh human subcutaneous white adipose tissue (scWAT). Human primary adipocytes derived from 28 female donors' fresh scWAT were used to examine the effects of irisin on browning and mitochondrial respiration, and preadipocytes were used to examine the effects of irisin on adipogenesis and osteogenesis. Cultured fragments of scWAT and perirenal brown fat were used for investigating signal transduction pathways that mediate irisin's browning effect by Western blotting to detect phosphorylated forms of p38, ERK, and STAT3 as well as uncoupling protein 1 (UCP1)...
August 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27432282/fndc5-expression-and-circulating-irisin-levels-are-modified-by-diet-and-hormonal-conditions-in-hypothalamus-adipose-tissue-and-muscle
#19
B M Varela-Rodríguez, L Pena-Bello, P Juiz-Valiña, B Vidal-Bretal, F Cordido, S Sangiao-Alvarellos
Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum irisin and FNDC5 mRNA expression levels, we evaluated plasma irisin levels and FNDC5 gene expression in the hypothalamus, gastrocnemius muscle and different depots of adipose tissue in models of altered metabolism. In normal rats, blood irisin levels diminished after 48-h fast and with leptin, insulin and alloxan treatments, and serum irisin concentrations increased in diabetic rats after insulin treatment and acute treatments of irisin increased blood insulin levels...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27388329/brain-derived-neurotrophic-factor-val66met-human-polymorphism-impairs-the-beneficial-exercise-induced-neurobiological-changes-in-mice
#20
Alessandro Ieraci, Alessandro I Madaio, Alessandra Mallei, Francis S Lee, Maurizio Popoli
Several studies have shown that exercise improves cognitive functions and emotional behaviors. Positive effects of exercise have been associated with enhanced brain plasticity, adult hippocampal neurogenesis, and increased levels of brain-derived neurotrophic factor (BDNF). However, a substantial variability of individual response to exercise has been described, which may be accounted for by individual genetic variants. Here, we have assessed whether and how the common human BDNF Val66Met polymorphism influences the neurobiological effects modulated by exercise in BDNF Val66Met knock-in male mice...
December 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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