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https://www.readbyqxmd.com/read/29143599/epistasis-physical-capacity-related-genes-and-exceptional-longevity-fndc5-gene-interactions-with-candidate-genes-foxoa3-and-apoe
#1
Noriyuki Fuku, Roberto Díaz-Peña, Yasumichi Arai, Yukiko Abe, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Carlos Spuch, José A Serra-Rexach, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
BACKGROUND: Forkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the presence of 'modifier genes', may contribute to explain the missing heritability of complex phenotypes such as EL. We assessed the potential association of epistasis among candidate polymorphisms related to physical capacity, as well as antioxidant defense and cardiometabolic traits, and EL in the Japanese population...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29127759/is-irisin-the-new-player-in-exercise-induced-adaptations-or-not-a-2017-update
#2
REVIEW
Ioannis G Fatouros
Irisin is produced by a proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has emerged as a potential mediator of exercise-induced energy metabolism. The purpose of this study was to review the results of studies that investigated irisin responses to acute and chronic exercise and provide an update. A comprehensive search in the databases of MEDLINE was performed (74 exercise studies). The focus of the analysis was on data concerning FNDC5 mRNA expression in skeletal muscle and circulating irisin concentration relatively to exercise mode, intensity, frequency and duration and the characteristics of the sample used...
November 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29108230/apigenin-enhances-skeletal-muscle-hypertrophy-and-myoblast-differentiation-by-regulating-prmt7
#3
Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Apigenin, a natural flavone abundant in various plant-derived foods including parsley and celery, has been shown to prevent inflammation and inflammatory diseases. However, the effect of apigenin on skeletal muscle hypertrophy and myogenic differentiation has not previously been elucidated. Here, we investigated the effects of apigenin on quadricep muscle weight and running distance using C57BL/6 mice on an accelerating treadmill. Apigenin stimulated mRNA expression of MHC (myosin heavy chain) 1, MHC2A, and MHC2B in the quadricep muscles of these animals...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966707/irisin-and-fibronectin-type-iii-domain-containing-5-responses-to-exercise-in-different-environmental-conditions
#4
Matthew P Bubak, Matthew W S Heesch, Robert J Shute, Nicholas E Dinan, Terence L Laursen, D Taylor LA Salle, Dustin R Slivka
Fibronectin type III domain-containing 5 (FNDC5) is a skeletal muscle membrane-bound precursor to the myokine irisin. Irisin is involved in stimulating adipose tissue to become more metabolically active in order to produce heat. The purpose of this study was to determine the effects of exercise in a hot (33 °C), cold (7 °C), and room temperature (RT, 20 °C) environment on the skeletal muscle gene expression of FNDC5 and the plasma concentrations of irisin. Twelve recreationally trained males completed three separate, 1 h cycling bouts at 60% of Wmax in a hot, cold, and RT environment followed by three hours of recovery at room temperature...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28961497/irisin-protects-against-neuronal-injury-induced-by-oxygen-glucose-deprivation-in-part-depends-on-the-inhibition-of-ros-nlrp3-inflammatory-signaling-pathway
#5
Juan Peng, Xian Deng, Wei Huang, Ji-Hua Yu, Jian-Xiong Wang, Jie-Ping Wang, Shi-Bin Yang, Xi Liu, Li Wang, Yun Zhang, Xiang-Yu Zhou, Hui Yang, Yan-Zheng He, Fang-Yuan Xu
Recent studies found that irisin, a newly discovered skeletal muscle-derived myokine during exercise, is also synthesized in various tissues of different species and protects against neuronal injury in cerebral ischemia. The NOD-like receptor pyrin 3 (NLRP3) inflammasome play an important role in detecting cellular damage and mediating inflammatory responses to aseptic tissue injury during ischemic stroke. However, it is unclear whether irisin is involved in the regulation of NLRP3 inflammasome activation during ischemic stroke...
November 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28944087/exercise-induced-irisin-in-bone-and-systemic-irisin-administration-reveal-new-regulatory-mechanisms-of-bone-metabolism
#6
Jin Zhang, Paloma Valverde, Xiaofang Zhu, Dana Murray, Yuwei Wu, Liming Yu, Hua Jiang, Michel M Dard, Jin Huang, Zhiwei Xu, Qisheng Tu, Jake Chen
Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain-containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein 1 (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo...
2017: Bone Research
https://www.readbyqxmd.com/read/28844533/irisin-stimulates-gonadotropins-gene-expression-in-tilapia-oreochromis-niloticus-pituitary-cells
#7
Quan Jiang, Qianli Zhang, Anji Lian, Yue Xu
The link between energy metabolism and reproduction is well known in vertebrates. Irisin, the product of fibronectin type III domain-containing protein 5 (FNDC5) gene, plays an important role in energy homeostasis. However, biological actions of irisin on reproduction remain elusive. To address this gap, we examined the direct effects of irisin on luteinizing hormone β (LHβ) and follicle-stimulating hormone β (FSHβ) gene expression in tilapia pituitary cells. As a first step, the transcripts of FNDC5 were detected in the proximal pars distalis (PPD), but not in the rostral pars distalis (RPD) and neurointermediate lobe (NIL) of the tilapia pituitary by RT-PCR...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28801552/gene-location-expression-and-function-of-fndc5-in-meishan-pigs
#8
Chunbo Cai, Gaojun Xiao, Lili Qian, Shengwang Jiang, Biao Li, Shanshan Xie, Ting Gao, Xiaorong An, Wentao Cui, Kui Li
Irisin is a new muscular regulatory factor that is generated by the cleavage of its precursor protein fibronectin type III domain-containing protein 5 (FNDC5). Irisin promotes fat consumption due to its stimulatory role in the browning of the adipocytes in mice. Currently, there is no report on FNDC5 functions in pigs as model animals. In this study, we investigated the expression patterns and functions of FNDC5 in Meishan pigs. Our results showed that FNDC5 gene in Meishan pigs contains five transcripts, all of which can be translated into functional intact irisin proteins...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771499/irisin-regulates-cardiac-physiology-in-zebrafish
#9
Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P Weber, Suraj Unniappan
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). We aimed to study the role of irisin on cardiac function and muscle protein regulation in zebrafish. Western blot analyses detected the presence of irisin protein (23 kDa) in zebrafish heart and skeletal muscle, and irisin immunoreactivity was detected in both tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28733331/n-glycosylation-is-required-for-fdnc5-stabilization-and-irisin-secretion
#10
Yongwei Nie, Dongjun Liu
Irisin, a myokine derived from the extracellular domain of FNDC5, has been shown to mediate thermogenesis of white adipose tissue. Biochemical data have shown that N-glycosylation of FNDC5 is unlikely to affect ligand or receptor activation of irisin. The N-glycosylation of FNDC5 remains poorly understood. In the present study, we analysed N-glycosylation sites of FNDC5 and found that two potential N-glycosylation sites (Asn(36) and Asn(81)) could indeed be occupied by N-glycan. Furthermore we showed that the lack of N-glycosylation decreases the secretion of irisin, which is relevant to the instability of FNDC5 and the deficiency of cleavage of the signal peptide...
September 7, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28676551/increased-fndc5-is-associated-with-insulin-resistance-in-high-fat-fed-mice
#11
Brianne L Guilford, Jake C Parson, Caleb W Grote, Stephanie N Vick, Janelle M Ryals, Douglas E Wright
FNDC5/irisin, has recently been identified as a novel protein that stimulates the "browning" of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet-induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise. C57BL/6 mice were randomized into three groups for the 4 week intervention: Standard diet (Std, n = 12), High fat diet (HF, n = 14), or High fat diet and free access to a running wheel (HFEX, n = 14)...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28666854/small-interfering-rna-mediated-knockdown-of-irisin-suppresses-food-intake-and-modulates-appetite-regulatory-peptides-in-zebrafish
#12
Lakshminarasimhan Sundarrajan, Suraj Unniappan
Irisin is a myokine encoded in fibronectin type III domain containing 5 (FNDC5). FNDC5 forms an integral part of the muscle post-exercise, and causes an increase in energy expenditure in mammals. Irisin is abundantly expressed in cardiac and skeletal muscles and is secreted upon activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). Irisin regulates feeding behaviour and cardiovascular function in mammals. More recently, irisin has gained importance as a potential biomarker for myocardial infarction due to its abundance in cardiac muscle...
October 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28620456/effects-of-physical-activity-on-the-link-between-pgc-1a-and-fndc5-in-muscle-circulating-%C3%AE-risin-and-ucp1-of-white-adipocytes-in-humans-a-systematic-review
#13
Petros C Dinas, Ian M Lahart, James A Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D Flouris, George S Metsios
Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Methods: Two databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016) were searched using an appropriate algorithm...
2017: F1000Research
https://www.readbyqxmd.com/read/28595171/serum-irisin-predicts-mortality-risk-in-acute-heart-failure-patients
#14
Shutong Shen, Rongrong Gao, Yihua Bei, Jin Li, Haifeng Zhang, Yanli Zhou, Wenming Yao, Dongjie Xu, Fang Zhou, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Yongqin Li, Junjie Xiao, Xinli Li
BACKGROUND/AIMS: Irisin is a peptide hormone cleaved from a plasma membrane protein fibronectin type III domain containing protein 5 (FNDC5). Emerging studies have indicated association between serum irisin and many major chronic diseases including cardiovascular diseases. However, the role of serum irisin as a predictor for mortality risk in acute heart failure (AHF) patients is not clear. METHODS: AHF patients were enrolled and serum was collected at the admission and all patients were followed up for 1 year...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28594316/effects-of-irisin-and-exercise-on-metabolic-parameters-and-reproductive-hormone-levels-in-high-fat-diet-induced-obese-female-mice
#15
Ercan Bastu, Umit Zeybek, Ebru Gurel Gurevin, Bahar Yüksel Ozgor, Faruk Celik, Nazli Okumus, Irem Demiral, Ozlem Dural, Cem Celik, Huri Bulut, Elif Ilkay Armutak, Bulent Baysal, Faruk Buyru, John Yeh
It has been documented that exogenously administered irisin (10(10) fibronectin-type III domain-containing 5 [FNDC5]), which is a new polypeptide hormone, induces the browning of subcutaneous fat and thermogenesis. In this study, effects of physical activity and exogenous administration of irisin were investigated on parameters related with reproduction and metabolism in the high-fat diet-induced obesity model of the female C57BL/6J mice. Sixty mice were gathered at age approximately 5 to 6weeks and were divided into 3 groups...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28534711/expressions-of-irisin-and-urotensin-ii-and-their-relationships-with-blood-pressure-in-patients-with-preeclampsia
#16
Li-Jie Zhang, Qian Xie, Chao-Shu Tang, Ai-Hua Zhang
The aims of this study are to observe irisin and urotensin II (UII) levels in serum and placenta in normal pregnant and preeclamptic women and investigate the relationship between expressions irisin and UII, and their association with blood pressure. A total of 67 pregnant subjects were recruited, including 31 healthy and 36 preeclamptic pregnant women. Serum irisin and UII concentrations were measured. Expressions of fibronectin type III domain-containing protein 5 (FNDC5) (irisin precursor) and UII in placenta specimens were performed...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28495843/treating-fructose-induced-metabolic-changes-in-mice-with-high-intensity-interval-training-insights-in-the-liver-white-adipose-tissue-and-skeletal-muscle
#17
Victor Faria Motta, Thereza Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). In the 10th week, for an additional eight-week period the groups were divided into non-trained (NT) or HIIT groups, totaling four groups: C-NT, C-HIIT, F-NT, and F-HIIT...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28479383/association-of-irisin-and-fndc5-rs16835198-g-t-gene-polymorphism-with-type-2-diabetes-mellitus-and-diabetic-nephropathy-an-egyptian-pilot-study
#18
Emad Gamil Khidr, Shawkey Saddik Ali, Mostafa Mahmoud Elshafey, Olfat Ahmed Fawzy
Diabetes mellitus is a fast-growing health problem in Egypt affecting morbidity, mortality and health care resources. Irisin, a new exercise-induced myokine inducing browning of white adipose tissues, has gained a great interest as a potential new target for combating type 2 diabetes mellitus (T2DM) and its complications. In this study, we assessed serum irisin levels in T2DM and diabetic nephropathy to elucidate possible relationships between irisin and metabolic parameters and renal functions. We also investigated, for the first time in Egypt, the association of FNDC5 rs16835198 G>T polymorphism with T2DM, diabetic nephropathy and irisin levels...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28472477/fibronectin-type-iii-domain-containing-protein-5-rs3480-a-g-polymorphism-irisin-and-liver-fibrosis-in-patients-with-nonalcoholic-fatty-liver-disease
#19
Salvatore Petta, Luca Valenti, Gianluca Svegliati-Baroni, Massimiliano Ruscica, Rosaria Maria Pipitone, Paola Dongiovanni, Chiara Rychlicki, Nicola Ferri, Calogero Cammà, Anna Ludovica Fracanzani, Irene Pierantonelli, Vito Di Marco, Marica Meroni, Debora Giordano, Stefania Grimaudo, Marco Maggioni, Daniela Cabibi, Silvia Fargion, Antonio Craxì
Context: Contrasting data have been reported on the role of irisin, a novel myokine encoded by the fibronectin type III domain-containing protein 5 (FNDC5) gene, in nonalcoholic fatty liver disease (NAFLD) pathogenesis. We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models...
August 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28437576/irisin-and-musculoskeletal-health
#20
REVIEW
Graziana Colaianni, Saverio Cinti, Silvia Colucci, Maria Grano
Irisin is a hormone-like myokine produced in abundance by skeletal muscle in response to exercise, both in mice and humans. Once released into the circulation, irisin acts on white adipocytes to induce the browning response and subsequently activates nonshivering thermogenesis. We have examined the premise that irisin produced during exercise may subserve further functions in the musculoskeletal system. We review evidence for its possible skeletal effects, including the central role that irisin plays in the control of bone mass, with positive effects on cortical mineral density and geometry in mice...
August 2017: Annals of the New York Academy of Sciences
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