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https://www.readbyqxmd.com/read/28620456/effects-of-physical-activity-on-the-link-between-pgc-1a-and-fndc5-in-muscle-circulating-%C3%AE-risin-and-ucp1-of-white-adipocytes-in-humans-a-systematic-review
#1
Petros C Dinas, Ian M Lahart, James A Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D Flouris, George S Metsios
Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Methods: Two databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016) were searched using an appropriate algorithm...
2017: F1000Research
https://www.readbyqxmd.com/read/28595171/serum-irisin-predicts-mortality-risk-in-acute-heart-failure-patients
#2
Shutong Shen, Rongrong Gao, Yihua Bei, Jin Li, Haifeng Zhang, Yanli Zhou, Wenming Yao, Dongjie Xu, Fang Zhou, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Yongqin Li, Junjie Xiao, Xinli Li
BACKGROUND/AIMS: Irisin is a peptide hormone cleaved from a plasma membrane protein fibronectin type III domain containing protein 5 (FNDC5). Emerging studies have indicated association between serum irisin and many major chronic diseases including cardiovascular diseases. However, the role of serum irisin as a predictor for mortality risk in acute heart failure (AHF) patients is not clear. METHODS: AHF patients were enrolled and serum was collected at the admission and all patients were followed up for 1 year...
June 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28594316/effects-of-irisin-and-exercise-on-metabolic-parameters-and-reproductive-hormone-levels-in-high-fat-diet-induced-obese-female-mice
#3
Ercan Bastu, Umit Zeybek, Ebru Gurel Gurevin, Bahar Yüksel Ozgor, Faruk Celik, Nazli Okumus, Irem Demiral, Ozlem Dural, Cem Celik, Huri Bulut, Elif Ilkay Armutak, Bulent Baysal, Faruk Buyru, John Yeh
It has been documented that exogenously administered irisin (10(10) fibronectin-type III domain-containing 5 [FNDC5]), which is a new polypeptide hormone, induces the browning of subcutaneous fat and thermogenesis. In this study, effects of physical activity and exogenous administration of irisin were investigated on parameters related with reproduction and metabolism in the high-fat diet-induced obesity model of the female C57BL/6J mice. Sixty mice were gathered at age approximately 5 to 6weeks and were divided into 3 groups...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28534711/expressions-of-irisin-and-urotensin-ii-and-their-relationships-with-blood-pressure-in-patients-with-preeclampsia
#4
Li-Jie Zhang, Qian Xie, Chao-Shu Tang, Ai-Hua Zhang
The aims of this study are to observe irisin and urotensin II (UII) levels in serum and placenta in normal pregnant and preeclamptic women and investigate the relationship between expressions irisin and UII, and their association with blood pressure. A total of 67 pregnant subjects were recruited, including 31 healthy and 36 preeclamptic pregnant women. Serum irisin and UII concentrations were measured. Expressions of fibronectin type III domain-containing protein 5 (FNDC5) (irisin precursor) and UII in placenta specimens were performed...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28495843/treating-fructose-induced-metabolic-changes-in-mice-with-high-intensity-interval-training-insights-in-the-liver-white-adipose-tissue-and-skeletal-muscle
#5
Victor Faria Motta, Thereza Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). In the 10th week, for an additional eight-week period the groups were divided into non-trained (NT) or HIIT groups, totaling four groups: C-NT, C-HIIT, F-NT, and F-HIIT...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28479383/association-of-irisin-and-fndc5-rs16835198-g-t-gene-polymorphism-with-type-2-diabetes-mellitus-and-diabetic-nephropathy-an-egyptian-pilot-study
#6
Emad Gamil Khidr, Shawkey Seddik Ali, Mostafa Mahmoud El-Shafaey, Olfat Ahmed Fawzy
Diabetes mellitus is a fast-growing health problem in Egypt affecting morbidity, mortality and health care resources. Irisin, a new exercise-induced myokine inducing browning of white adipose tissues, has gained a great interest as a potential new target for combating type 2 diabetes mellitus (T2DM) and its complications. In this study, we assessed serum irisin levels in T2DM and diabetic nephropathy to elucidate possible relationships between irisin and metabolic parameters and renal functions. We also investigated, for the first time in Egypt, the association of FNDC5 rs16835198 G<T polymorphism with T2DM, diabetic nephropathy and irisin levels...
May 4, 2017: Gene
https://www.readbyqxmd.com/read/28472477/fibronectin-type-iii-domain-containing-protein-5-rs3480-a-g-polymorphism-irisin-and-liver-fibrosis-in-patients-with-nonalcoholic-fatty-liver-disease
#7
Salvatore Petta, Luca Valenti, Gianluca Svegliati-Baroni, Massimiliano Ruscica, Rosaria Maria Pipitone, Paola Dongiovanni, Chiara Rychlicki, Nicola Ferri, Calogero Cammà, Anna Ludovica Fracanzani, Irene Pierantonelli, Vito Di Marco, Marica Meroni, Debora Giordano, Stefania Grimaudo, Marco Maggioni, Daniela Cabibi, Silvia Fargion, Antonio Craxì
Context: Contrasting data have been reported on the role of irisin, a novel myokine encoded by the FNDC5 gene, in NAFLD pathogenesis. We tested in patients with suspected NASH the association of FNDC5 variants, hepatic expression and circulating irisin with liver damage(F2-F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models. Methods: We considered 593 consecutive patients, who underwent liver biopsy for suspected NASH and 192 patients with normal liver enzymes and without steatosis...
May 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28437576/irisin-and-musculoskeletal-health
#8
Graziana Colaianni, Saverio Cinti, Silvia Colucci, Maria Grano
Irisin is a hormone-like myokine produced in abundance by skeletal muscle in response to exercise, both in mice and humans. Once released into the circulation, irisin acts on white adipocytes to induce the browning response and subsequently activates nonshivering thermogenesis. We have examined the premise that irisin produced during exercise may subserve further functions in the musculoskeletal system. We review evidence for its possible skeletal effects, including the central role that irisin plays in the control of bone mass, with positive effects on cortical mineral density and geometry in mice...
April 24, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28437200/effects-of-dietary-macronutrient-composition-on-fndc5-and-irisin-in-mice-skeletal-muscle
#9
Simone Moreira de Macêdo, Deborah de Farias Lelis, Keila Lopes Mendes, Carlos Alberto de Carvalho Fraga, Igor V Brandi, Jonh David Feltenberger, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique de Sousa Santos
BACKGROUND: Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. METHODS: Twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD)...
May 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28377712/pgc-1%C3%AE-or-fndc5-is-involved-in-modulating-the-effects-of-a%C3%AE-1-42-oligomers-on-suppressing-the-expression-of-bdnf-a-beneficial-factor-for-inhibiting-neuronal-apoptosis-a%C3%AE-deposition-and-cognitive-decline-of-app-ps1-tg-mice
#10
De-Yu Xia, Xin Huang, Chong-Feng Bi, Lin-Ling Mao, Li-Jun Peng, Hai-Rong Qian
Alzheimer's disease (AD) is generally defined as the aberrant production of β-amyloid protein (Aβ) and hyperphosphorylated tau protein, which are deposited in β-amyloid plaques (APs) and neurofibrillary tangles (NFTs), respectively. Decreased levels of brain-derived neurotrophic factor (BDNF) have been detected in patients with AD compared to control subjects. However, the underlying molecular mechanisms driving the downregulation of the BDNF remain unknown. Therefore, we explored the mechanisms underlying the regulation of BDNF in the neurons of APP/PS1 transgenic (Tg) mice, an AD experimental model...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28287024/combined-training-fndc5-irisin-levels-and-metabolic-markers-in-obese-men-a-randomised-controlled-trial
#11
Ivan Luiz Padilha Bonfante, Mara Patrícia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Wendell Arhur Lopes, Valéria Bonganha, Cleiton Augusto Libardi, Cláudia Regina Cavaglieri
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13 ± 5.75, body mass index (BMI) 30.86 ± 1.63) were randomly distributed in the CT group (n = 12) and control group (CG n = 10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28240298/glucocorticoid-receptor-positively-regulates-transcription-of-fndc5-in-the-liver
#12
Hyoung Kyu Kim, Yu Jeong Jeong, In-Sung Song, Yeon Hee Noh, Kyo Won Seo, Min Kim, Jin Han
Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human metabolic diseases. Thus, we investigated the genetic and epigenetic mechanisms that regulate expression of the FNDC5 gene. FNDC5 mRNA was strong expressed in major energy-dependent human tissues, including heart, brain, liver, and skeletal muscle...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219696/irisin-in-goldfish-carassius-auratus-effects-of-irisin-injections-on-feeding-behavior-and-expression-of-appetite-regulators-uncoupling-proteins-and-lipoprotein-lipase-and-fasting-induced-changes-in-fndc5-expression
#13
Zahndra Diann Butt, Jessica Dalton Hackett, Hélène Volkoff
Irisin is a peptide cleaved from the fibronectin type III domain containing protein 5 (FNDC5) gene that is secreted predominantly by muscle cells but also by other tissues including brain and intestine. In mammals, irisin has been shown to have thermogenic actions via the modulation of uncoupling proteins (UCPs) and to affect feeding and energy homeostasis via actions in brain, adipose tissue, liver, muscle and gastrointestinal tract. To examine the role of irisin on feeding and metabolism in fish, the effects of peripheral (intraperitoneal) injections of irisin on feeding behavior, glucose levels and the mRNA expressions of appetite regulators (cocaine and amphetamine regulated transcript CART, agouti related protein AgRP, orexin), UCPs and lipoprotein lipase LPL and brain factors (brain-derived neurotrophic factor , BDNF and tyrosine hydroxylase TH) were assessed in brain, white muscle and intestine...
February 20, 2017: Peptides
https://www.readbyqxmd.com/read/28195643/a-prospective-evaluation-of-clinical-and-genetic-predictors-of-weight-changes-in-breast-cancer-survivors
#14
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28183451/the-novel-exercise-induced-hormone-irisin-protects-against-neuronal-injury-via-activation-of-the-akt-and-erk1-2-signaling-pathways-and-contributes-to-the-neuroprotection-of-physical-exercise-in-cerebral-ischemia
#15
Dong-Jie Li, Yong-Hua Li, Hong-Bin Yuan, Le-Feng Qu, Pei Wang
BACKGROUND: Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. In this study, we investigated the potential role of irisin in cerebral ischemia and determined whether irisin is involved in the neuroprotective effect of physical exercise in mice. MATERIALS AND METHODS: The middle cerebral artery occlusion (MCAO) model was used to produce cerebral ischemia in mice. First, the plasma irisin levels and changes in expression of the irisin precursor protein FNDC5 in skeletal muscle were determined post ischemic stroke...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28144410/can-resistance-exercise-alter-irisin-levels-and-expression-profiles-of-fndc5-and-ucp1-in-rats
#16
Jalil Reisi, Kamran Ghaedi, Hamid Rajabi, Sayyed Mohammad Marandi
BACKGROUND: Irisin is a new myokine secreted from the skeletal muscle and appears to affect the metabolism of adipose tissue. OBJECTIVES: The mechanisms of cellular and molecular identification by which exercise training exerts its benefits remain unclear and are under investigation. METHODS: We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles of muscle FNDC5 and subcutaneous adipose tissue UCP1 in male rats...
December 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/28108329/exercise-increases-mitochondrial-complex-i-activity-and-drp1-expression-in-the-brains-of-aged-mice
#17
Aaron M Gusdon, Jason Callio, Giovanna Distefano, Robert M O'Doherty, Bret H Goodpaster, Paul M Coen, Charleen T Chu
Exercise is known to have numerous beneficial effects. Recent studies indicate that exercise improves mitochondrial energetics not only in skeletal muscle but also in other tissues. While exercise elicits positive effects on memory, neurogenesis, and synaptic plasticity, the effects of exercise on brain mitochondrial energetics remain relatively unknown. Herein, we studied the effects of exercise training in old and young mice on brain mitochondrial energetics, in comparison to known effects on peripheral tissues that utilize fatty acid oxidation...
April 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28070911/effects-of-exercise-training-on-brain-derived-neurotrophic-factor-in-skeletal-muscle-and-heart-of-rats-post-myocardial-infarction
#18
Heow Won Lee, Monir Ahmad, Hong-Wei Wang, Frans H H Leenen
Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible mediators fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the skeletal muscle and heart. Male Wistar rats underwent either sham surgery or ligation of left descending coronary artery, and surviving MI rats were allocated to either sedentary (Sed-MI) or exercise group (ExT-MI)...
January 9, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28028076/inorganic-nitrate-mimics-exercise-stimulated-muscular-fiber-type-switching-and-myokine-and-%C3%AE-aminobutyric-acid-release
#19
RANDOMIZED CONTROLLED TRIAL
Lee D Roberts, Tom Ashmore, Ben D McNally, Steven A Murfitt, Bernadette O Fernandez, Martin Feelisch, Ross Lindsay, Mario Siervo, Elizabeth A Williams, Andrew J Murray, Julian L Griffin
Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic health. Inorganic nitrate increases exercise efficiency, tolerance, and performance. The transcriptional regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-twitch (type IIb) to oxidative slow-twitch (type I) and intermediate (type IIa) fibers, an effect reversed in insulin resistance and diabetes...
March 2017: Diabetes
https://www.readbyqxmd.com/read/28012856/increased-fndc5-irisin-expression-in-human-hepatocellular-carcinoma
#20
Melania Gaggini, Manuela Cabiati, Serena Del Turco, Teresa Navarra, Paolo De Simone, Franco Filipponi, Silvia Del Ry, Amalia Gastaldelli, Giuseppina Basta
The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still unknown. The gene expression of FNDC5/Irisin, associated to key regulators of DNL, inflammation and cancer progression was evaluated in liver tissue of 18 patients with HCC undergoing liver transplantation and of 18 deceased donors...
February 2017: Peptides
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